ʻO nā papa Symlo 5 mg: nā ʻōlelo a me nā loiloi i ka lāʻau lapaʻau
ICD: E78.0 hypercholesterolemia Pure E78.2 Hāpai ʻia hyperlipidemia
Kapehu
Ma hope o ka lawelawe waha, ua mālama maikaʻi ʻia ka simvastatin mai ka gastrointestinal tract (ma ka awelika 85%). Loaʻa ka Cmax i kahi mau hola 4 ma hope o ka nānā ʻana.
Ke lawe koke nei i ka lāʻau lapaʻau ma mua o ka ʻai ʻana me ka haʻahaʻa haʻahaʻa haʻahaʻa ʻaʻole i pili i ka f.
E hoʻokuʻu i ke ʻano
ʻAʻole i loaʻa i ka ʻike e pono ai?
ʻOi aku ka ʻōlelo piha pono loa no ka lāʻau "simlo (simlo)" hiki ke loaʻa ma aneʻi:
E nā kauka aloha!
Inā loaʻa iā ʻoe kahi ʻike i kēia lāʻau lapaʻau i kāu mau maʻi - e kaʻana i ka hopena (waiho i kahi ʻōlelo) Ua kōkua anei kēia lāʻau lapaʻau i ka mea maʻi, ua loaʻa paha kekahi hopena maikaʻi i ka wā o ka mālama ʻana? E nānā i kou ʻike i kāu mau hoa hana a me nā maʻi.
E nā maʻi maʻi!
Inā ua kau ʻia kēia lāʻau lapaʻau iā ʻoe a ua hele ʻoe i kahi ʻano o ka lāʻau lapaʻau, haʻi mai iaʻu inā maikaʻi (a inā paha na kōkua), inā he hopena kūpono paha, nā mea āu e makemake ai / ʻaʻole makemake. Ke nānā nei nā tausani o nā kānaka i nā loiloi pūnaewele ma waena o nā lāʻau lapaʻau. Aka, wale no e waiho ia lakou. Inā ʻaʻole ʻoe e waiho i ka pane i kēia kumuhana - ʻaʻohe mea e koe.
Nā hōʻailona no ka hoʻohana ʻana
IIa type IIa a me IIb hypercholesterolemia (inā maikaʻi ʻole ka mālama ʻana i ka ʻai i nā mea maʻi me ka piʻi nui o ka ulu ʻana i ka atherosclerosis coronary), ua hoʻohui ʻia ʻo hypercholesterolemia a me hypertriglyceridemia, hyperlipoproteinemia, ʻaʻole hiki ke hoʻoponopono ʻia e ka lāʻau kūikawā a me ka hana kino.
Kāohi i ka myocardial infarction (e hoʻolalelale i ka holomua o ka atherosclerosis coronary), ka pehu a me ka pilikia o ka lele ʻana o ka cerebral.
Pehea e hoʻohana ai: dosis a me ke ʻano o ka mālama ʻana
I loko, i hoʻokahi manawa, i ke ahiahi. Me ka hypercholesterolemia maʻalahi a maʻalahi paha, kahi mua ka 5 mg me ka hypercholesterolemia koʻikoʻi ma kahi hoʻomaka o 10 mg / lā, me ka haʻahaʻa o ka maʻi, hiki ke hoʻonui ʻia ka paʻakai (ʻaʻole i mua ma mua o 4 mau hebedoma), ʻo ka nui o kēlā me kēia lā he 80 mg.
Me ka maʻi puʻuwai coronary, ʻo ka nui o ka lāʻau mua ma mua o 20 mg (hoʻokahi, ma ke ahiahi), inā pono, e hoʻonui pinepine ʻia ka nui i kēlā me kēia 40 mau wiki a 40 mg. Inā emi mai ka ʻike o LDL ma mua o 75 mg / dl (1.94 mmol / L), ʻoi ka nui o ke kolamu ma mua o 140 mg / dl (3.6 mmol / L), pono ke hōʻemi ʻia ka ʻōpala.
I nā mea maʻi me ka maʻi renal kūwili ʻole (CC ma mua o 30 ml / min) a i ʻole ka loaʻa ʻana o ka cyclosporine, nā fibrates, nicotinamide, ʻo ka mua ka pāʻana o 5 mg, ʻo ka nui o kēlā me kēia lā he 10 mg.
Ka hana lāʻau lapaʻau
ʻO ka lālani ka hopena lipid ka mea i loaʻa synthetically mai ka huahana fermentation Aspergillus terreus he lactone hema ʻole, ke ʻano ia i ka hydrolysis i loko o ke kino e hana ai i kahi kumuhana hydroxy derivative. Hoʻopau ka metabolite hoʻoikaika i ka hoʻolaʻa HMG-CoA, kahi hoʻoneʻe e kāohi ai i ka hopena mua o ka hoʻokumu ʻana mai o ka mevalonate mai HMG-CoA. Mai ka hoʻohuli ʻana o ka HMG-CoA i mevalonate he ʻano mua i loko o ke kāpili ʻana o ka kolamu, ʻo ka hoʻohana ʻana i ka simvastatin ʻaʻole e waiho i ka hōʻuluʻulu ʻana o ka puhaka i ka mea make i loko o ke kino. Hoʻopili maʻalahi ka HMG-CoA i ka acetyl-CoA, kahi i komo i nā hana synthes nui i ke kino.
He hōʻemi ia i ka hoʻololi o TG, LDL, VLDL a me ka kolamu piha i ka plasma (i nā hihia he hemozygous familial a me nā ʻohana ʻole non-familial o ka hypercholesterolemia, me ka hyperlipidemia i hui pū ʻia, i ka wā o ka hoʻonui o ka cholesterol he mea hōʻeha). Hoʻonui i nā HDL a hoʻoemi i ka pae o ka LDL / HDL a me ka nui o ka cholesterol / HDL.
ʻO ka hoʻomaka ʻana o ka hana he 2 mau wiki ma hope o ka hoʻomaka ʻana o ka hoʻokele, ʻo ka hopena ka hopena o ka therapeutic ma hope o 4-6 mau pule. Ke hoʻomau nei ka hopena me ka hoʻomau ʻana o ka hoʻōla, me ka hoʻopau ʻana o ka hōʻola ʻana, e hoʻi hou ka ʻākala kolene i kona pae mua (ma mua o ka mālama ʻana).
Nā ʻōkuhi no ka hoʻohana
| Hōʻike Simlo
Nā mea hoihoi: nāʻai palaoa, lactose, microcrystalline cellulose, sodium starch glycolate, gelatinized starch, yellow iron oxide, isopropanol, hydroxytoluene butylate, wai i hoʻomaʻemaʻe ʻia, citric acid monohydrate, talc purified, magnesium stearate, hydroxyphenyl methylene dichlorop. 10 kamepiula - nā kāmele (2) - nā kīʻaha o ke kāleka.
Nā mea hoihoi: nāʻai palaoa, laktosa, cellulose microcrystalline, sodium starch glycolate, gelatinized starch, red iron oxide, isopropanol, hydroxytoluene butylate, wai huikala, ka citric acid monohydrate, talc purified, magnesium stearate, hydroxyphenylmethylene methylpropene 10 kamepiula - nā kāmele (2) - nā kīʻaha o ke kāleka.
Nā mea hoihoi: nāʻai palaoa, laktosa, cellulose microcrystalline, sodium starch glycolate, gelatinized starch, red iron oxide, isopropanol, hydroxytoluene butylate, wai huikala, ka citric acid monohydrate, talc purified, magnesium stearate, hydroxyphenylmethylene methylpropene 10 kamepiula - nā kāmele (2) - nā kīʻaha o ke kāleka.
pakuhi. makeha, 5 mg: 20, 28, 30 a 42 mau pcs.
pakuhi. makeha, 10 mg: 20, 28, 30 a 42 mau pcs.
pakuhi. makeha, 20 mg: 20, 28, 30 a 42 mau pcs. Nā Manaohao Simlo
- ka maʻi ōpū palolo, - ka maʻi ate ma ka pālohi, - he ulu mau ka hana o nā transaminases i ʻike ʻole ʻia, - lactation (umauma), - nā keiki a me nā wā'ōpiopio ma lalo o 17 makahiki. - Hypersensitivity i simvastatin a me nā mea ʻē aʻe o ka lāʻau lapaʻau, - Hoʻomoʻaʻike i ka maʻi hāpū i nā mea ʻē aʻe HMG-CoA. ʻO ka helu a me ka hoʻokele ʻo Simlo
Hoʻonohonoho ʻia ka pākeka dosage a me ka lōʻihi o ka mālama ʻana. Mamuli o ka paʻakikī o ka hypercholesterolemia, ʻo ka hoʻomaka mua ka 5 mg / lā. Me ka hypercholesterolemia koʻikoʻi - 10 mg 1 manawa / lā. Inā pono, e hoʻonui i ka pānāwai me ka manawa o 4 mau pule. ʻO ka pae ʻauʻau nui loa ʻo kēlā me kēia lā he 40 mg. Pono ka laʻa e lawe ʻia i ka manawa 1 / lā i ke ahiahi, ma mua o i ka wā o ka papaʻaina. No ka poʻe maʻi e loaʻa ana i ka immunosuppressants, ʻo ke ʻano hoʻomaka ʻana ʻo 5 mg / lā, ʻoi loa ka nui o kēlā me kēia lā he 5 mg / lā. ʻO nā mea maʻi me ka hōʻemi ʻole o ka pale i ʻole ka nui o ka hemahema e pono ai e hoʻoponopono i ka regimen dosage. No nā mea maʻi me ka maikaʻi ʻole o ka renal, ʻo ka nui o ka lāʻau mua he 5 mg / lā, ʻo kēia ʻano o nā maʻi e pono ai ka mālama olakino maʻamau. Ka hopena ʻaoʻao Simlo
Mai ka papa hana ʻana: pinepine - constipation, ʻeha, ka hoʻoluhi ʻana i ka ʻai, ʻokiʻī, nausea, hōʻeha o ka ʻōpū, pancreatitis, he mea mau paha e hoʻonui i ka pae o ka transaminases a me ka CPK i loko o ke koko koko (maʻamau i ka hopena o ka malama mua o ka hopena). I ka wā waena ma waena o ka wiki a me ka 4 o ka wiki mai ka hoʻomaka o ka hoʻōla, hiki ke piʻi i kahi kiʻekiʻe o ke koko plasma o ALT, AST a me ka phosphatase alkaline. ʻO ka hoʻonui kiʻekiʻe loa i kēia mau kuhikuhi ke ʻike ʻia a kokoke i ka 8th pule o ka mālama ʻana. Ma hope o ka hoʻokuʻu ʻana i ka lāʻau lapaʻau, hōʻemi ʻia nā pae o ka enzyme i nā pae maʻamau. Ma ka ʻāpana o ka ʻōnaehana cardiovascular: hiki i ka hypotension arterial (ʻoi aʻe ka loaʻa o ka wā lawe ka lāʻau i ka maʻa o ka nui o 10 mg / lā, e hele hou ana i ke ʻano a ʻaʻole ia e koi i ka hoʻoponopono o ka regimen dosage). Mai ka pūnaehana pīhoihoi waena a me nā ʻōnaehana nerve peripheral: hopohopo, pilikia ka hiamoe, asthenia, mahele ʻia ka maʻi lahilahi. Mai ka papa musculoskeletal: luhi - myopathy, rhabdomyolysis. Mai ka ʻōnaehana hemopoietic: luhi - eosinophilia, thrombocytopenia. Nā maʻi hawewe: pilikia - urticaria, angioedema. ʻO nā mea ʻē aʻe: ʻaʻohe - photosensitization, vasculitis, lupus-like syndrome. Hoʻomaʻi maikaʻi ʻia ka lāʻau. ʻO nā hopena ʻaoʻao ka mea maʻalahi a maʻalahi.
Hāʻawi ʻia ka ʻikepili ma kahi overdose o ka lāʻau Simlo.
Me ka hoʻohana like ʻana o Simlo me nā immunosuppressants (cyclosporine), erythromycin, gemfibrozil, acid acidotinic, ka hopena o ka rhabdomyolysis a me ka hopena o ke kūleʻa ʻole e hoʻonui i ka maʻi. Me ka hoʻohana pū ʻana o Simlo me nā anticoagulants kūpaʻa, kahi i hiki ai ke hoʻonui aʻe i ka hana pharmacological o nā mea hope loa. Me ka hoʻohana like ʻana o Simlo me colestyramine, ke emi nei ka bioavailability o simvastatin (ua hōʻike ʻia e lawe iā Simlo 4 mau hola ma hope o ka lawe ʻana o colestyramine). Me ka hana like o Simlo me digoxin, he piʻi nui i ka neʻe ʻana o ka mea i loko o ka plasma.
Me ka makaʻala koʻikoʻi, pono ke hoʻomaopopo i ka lāʻau i nā poʻe maʻi e hōʻino maikaʻi ʻole i ka waiʻona a me / a me kekahi moʻolelo o nā maʻi o ka ate. Me ka makaʻala, pono ke kuhikuhi ʻia ka lāʻau i nā mea maʻi ma hope o ka hiki ke hoʻololi i ka organun e loaʻa ana i ka immunosuppressants, ma muli o ka nui o ka nui o ka rhabdomyolysis a me ka hoʻomohala ʻana o ka maikaʻi ʻole. Me ka hypotension arterial, maʻi maʻi maʻiʻeha, me ka hōʻeha o ka metabolic koʻikoʻi, ʻoihana endocrine, ke kaupaona wai-electrolyte, i ka wā o ka hōʻemi o ka ʻeha (me nā dental) a i ʻole nā hōʻeha, i nā mea maʻi me nā hōʻemi a hoʻonui ʻia paha o nā ʻōpū o nā ʻihi o nā ʻolelo e ʻike ʻoliʻoli, me ka epilepsy, ka lāʻau lapaʻau i kauoha ʻia me ka makaʻala, no ka mea me nā maʻi i papa inoa ʻia a me nā kūlana hiki ke piʻi i ka maʻi renal koʻikoʻi. Ka nānā ʻana o ka lawena ʻana I ka wā o ka hoʻohana ʻana i ka lāʻau lapaʻau, pono e kāohi i ka paukū kolamu o ka plasma. Lawe ʻia ka haʻawina mua 4 mau pule ma hope o ka hoʻomaka ʻana o ka lāʻau lapaʻau, a laila mālama ʻia ka nānā mau ʻōnaehana maʻamau o kēia hōʻailona. Ma mua a i ka wā e mālama ai me ka lāʻau lapaʻau, pono e nānā pono ʻia ka ʻike o ka hoʻonaninani o ka ate i loko o ka serum: i ka 3 mau mahina o ka mua o ka lapaʻau, mālama ʻia ka ʻike me kahi he 6 o nā pule, a laila ma kēlā me kēia 6 mau mahina. Me ka hoʻonui nui o ka pae seramin transaminase e ʻoi aku ma mua o 3 mau manawa i hoʻohālikelike ʻia i nā pae palena, pono e hoʻoneʻe ʻia ka mālama ʻana me Simlo. I ka wā o ka hoʻohana ʻana i ka lāʻau, pono ia e kaohi i ke kiʻekiʻe o ka CPK i nā mea maʻi e loaʻa i nā immunosuppressants a me nā acid nicotinic, a me ka myopathy (myalgia, nāwaliwali o ka mākuhi). Me ka piʻi o ka pae o ka CPK ma mua o 10 mau manawa i hoʻohālikelike ʻia me nā kumu maʻamau, pono e hoʻokuʻu ʻia ka lāʻau.
E mālama ʻia ka lāʻau lapaʻau i kahi maloo, pale ʻia mai ka mālamalama, ʻaʻole hiki i nā keiki ke ana i kahi wela ʻaʻole iʻoi aku ma mua o 25 ° C. ʻO 2 mau makahiki kahi ola. ʻAʻole pono e hoʻohana ʻia ka lāʻau lapaʻau ma hope o ka lā pau i hōʻike ʻia ma ka pōpeku. ʻO ka hiʻohiʻona o ka lāʻau lapaʻauHoʻopili ʻia kēlā me kēia tablet Simlo me kahi kāʻei kiʻi kiʻi kū hoʻokahi, a ua loaʻa i kēia ʻano inoa: ʻO ka papa hana: simvastatin 10,000 mg
Ka kinona ka mea: hypromellose, tolk, titanium dioxide 0.520 mg, kahe hao hao kaole ʻona i loko o 0.002 mg, macrogol-400 0.120 mg., Iron oxide red oxide 0.038 mg. ʻO kēlā me kēia papa ʻo Simlo 20 mg me ka pale ʻia ʻoniʻoni: Hoʻokomo i ka wai: sangkap simvastatin 20,000 mg.
Pahu ka papa papa: talcum mass 1,040 mg, hypromellose ma ka nui o ka 2,400 mg, titanium dioxide i ka nui o ka 1,040 mg, iron dye oxide 0,036 mg, macrogol-400 0,240 mg, kaila hao kahe ʻona wai 0,044 mg.
Hōʻike ʻia ʻo Simlo no ka hoʻohana ʻana i kekahi mau kūlana:
Hoʻomili hou a me ke ʻano hoʻohālikelikeʻO ka Simlo kahi puka dosis e loaʻa ai ka hopena lipid-lowing. ʻO ka hoʻolālā o ka hopena therapeutic ka paleʻana i ka hana enzymatic o HMG-CoA reductase. Hoʻokuʻu i ka puka Simlo - nā kākō a me nā papa, pena ʻia nā kiʻi ma luna. I loko o kā mākou mākeke lāʻauʻai he ʻekolu mau loli o ka nui - 5, 10 a me 20 mg. ʻO ke ʻano waiwai - simvastatin (simvastatin - e like me ka radar - lāʻau kuhikuhi lāʻau). Nā kumuwaiwai hou e hoʻomālamalama i ka papa ʻaina: starch corn, ferrum oxide, 4-valent titanium oxide, microcrystalline a me hydroxypropylmethyl cellulose, isopropanol, methylene chloride, citric acid monohala. ʻO nā hopena lāʻau lapaʻau o ka hoʻohana ʻana i kēia simvastatin e pili pū ana i kona hiki ke pale i ka hana o ka cholesterol precursor e ke kino. No laila, ma hope o kona hoʻohanaʻana, aia ke emi ʻana o nā māhele o nā momona i ke koko. Ma keʻano pilikino, ʻoi aku ka ʻike o ka triglycerides, LDL a me VLDL, ua emi ka nui o ka kolamu, ka pae o ka lipoproteins i kēlā me kēia, e hoʻomaikaʻi ʻia, a ʻo ka huina o ka kolesterol a pau i kāna mau kūmole (ʻo ka ʻike o ka kolamu a me HDL ke hoʻololi mau ʻia). ʻO ka hopena therapeutic e loaʻa i ʻelua mau pule ma hope o ka hoʻomaka ʻana e lawe iā Simlo. ʻO ka kuhi o ka hopena therapeutic e hele mai i ka manawa mai ka ʻehā a hiki i ke ono o ka hebedoma o ka hoʻohana ʻana o statin. Eia kekahi, hoʻomau kēia hopena i ka wā o ka mālama ʻana, akā ke hoʻokaʻawale ke keaka, e hoʻi hou ka haki palaka lipid i ka pae mua ma mua o ka mālama ʻana i ka lāʻau.
ʻO nā ala nui o ka excretion o ke koena o ka lāʻau i ke bile a me nā pōpoki. ʻO ia ke kumu, ʻaʻole ia i hoʻokaʻawale ʻia ka symlo no nā maʻi o ka pūpū a me ka ate i ka mahele o nā hōʻike keu. I ka wā o ka hoʻohana ʻana i ka simvastatin, nā kaila transaminases a me ka CPK e nānā pono ʻia. No nā enzyme plasma hepatic, pono e hana ʻia ka noiʻi mua ʻeono mau pule ma hope o ka hoʻomaka ʻana o ka mālama ʻana. Nā hopena hopenaI nā hihia liʻiliʻi, hiki i ke kino o ka mea maʻi ke hāʻawi i nā helu pane i ka hoʻohana ʻana i symlo. Hōʻike ʻia kēia mau hiʻohiʻona i kēia ʻōpiopio hiki i kēia.
Inā loaʻa iā ʻoe kekahi a i ʻole kekahi o nā hōʻailona i hōʻike ʻia ma luna, pono koke e hoʻopili aku i kāu kauka a, inā pono, e hōʻemi i ka nui o ka lāʻau, a i ʻole hōʻea i kona hoʻohana ʻana. Hoʻopili pū me nā lāʻau ʻē aʻeHoʻohui pono ʻia ʻo Simlo me nā lāʻau lapaʻau e like me fibrates (gemfibrozil), cyclosporine, niacin, erythromycin, a me kekahi o kā lākou mau analogues. I ka manawa i pili pū me lākou, hoʻonui ka bioavailability o nā lāʻau lapaʻau, hoʻonui nui ko lākou plasma, ka nui o ka noho ʻana o ka rhabdomyolysis i kekahi mau manawa, ukali ʻia e ka papala ʻole, a me ke ʻano nui me ka arterial hypotension. Ke hoʻohui me nā anticoagulants, hiki i ka simvastatin ke hoʻoikaika i kā lākou hopena. Pono e nānā pono i nā poʻe maʻi me ka loaʻa ʻole o ka naʻau e loaʻa ke mālama me ka glycosides cardiac - digoxin. Hoʻonui nui ʻo Simvastatin i kona neʻe i ka plasma, ka mea i hāʻawi i nā waiwai o glycoside, hiki ke hāʻawi i nā hoʻopiʻi koʻikoʻi i ka lolo cardiovascular, hoʻonui i ka maʻi naʻau. Nā kikowaena SimloI kā mākou mākeke huahana, Simlo statin he nui nā helu. Hoʻopili kēia mau mea i nā waiwai o ka waiwai - Simvakard 10, 20, 40 mg, Simgal 10, 20 a 40 mg, Vasilip 10, 20 a 40 mg. Hāʻawi ʻia nā substitutes. mamuli o ke kumu o na hana. ^ E Ha yM. Eia, ʻaʻole aneane ka laina o nā lāʻau lapaʻau a me nā loea - mai Atorvastatin, Torvakard, Atoris, Liprimar, Krestor, i Holetar, Lipostat, Livazo a me Rosucard. Loaʻa lākou āpau i nā hopena lipid-hoʻemi i loko o nā hua nui o nā lāʻau lapaʻau - statins. Nā Hōʻike Hoʻohana
Pavelko P.A. Kiev, 65 mau makahiki, penikala: “Ma nā makahiki ʻehā i hala iho nei, ua kuhikuhi ke kauka iā Simlo iaʻu, no ka mea he nui nā kuhi hewa ʻana mai ka kiʻi lipid. Ke hiki ʻole nei iaʻu ke haʻi maopopo, ua hoʻomanaʻo wau aia nā lua kiʻekiʻe a me ka triglycerides, aneane ua hoʻokiʻekiʻe ʻia ka holoʻokoʻa holoʻokoʻa. ʻĀnō wau i kēlā lā i kēia lā i kahi hīnaʻi a me ke olakino olakino. ʻO ka mea hili ʻole wale ia i kēia manawa o koʻu ola āpau e noho ai ma luna o nā papa. ʻ saidlelo ke kaukaʻi ma hope o ka hoʻokuʻu ʻana i ka lāʻau me ka lāʻau lapaʻau, e hoʻi mai nā kaʻe o koʻu mau koko koko, no laila pono wau e hoʻomau mau iā ia. ” He kūpono nā loiloi e pili ana iā Simlo mai nā kauka a me nā mea maʻi i ka nui o nā hihia. ʻO kēia ma muli o ke kumukūʻai maikaʻi / pae maikaʻi loa, me ka manawa lōʻihi, a me ka mea nui, ka ʻike maikaʻi a hiki i ka hoʻohana ʻana i kēia lāʻau lapaʻau i ka lāʻau lapaʻau. Ka mea i hōʻoiaʻiʻo ʻia ai ka paʻa o ka HMG-CoA reductase, he pālahalaha pālahalaha i loko o nā koina kalepa a hiki ʻole ke hāʻawi i nā hopena ʻaoʻao. Nā ʻōkuhi no kēia lāʻauʻO kēlā me kēia paena i ka lāʻau lapaʻau Simlo e loaʻa nā kuhikuhi no ka hoʻokomo. ʻO nā ʻōlelo no ka lāʻau lapaʻau ka ʻike ʻikepili e pili ana i nā hōʻailona, ka dosage pono, nā hopena ʻaoʻao, ka contraindications, ke ʻano o ka hoʻokuʻu ʻana, ka hoʻopuka ʻana, nā hana no ka overdose, ke ʻano o ka hoʻokele ʻana, nā kūlana hoʻokipa i ka wā hāpai a me ka pale ʻana, nā kūlana mālama, a me ke ola o ka noho. Eia kekahi, aia nō hoʻi nā ʻikepili i nā kumukūʻai a me nā kikowaena. LapaʻauHoʻolālā ʻia ka lāʻau lapaʻau ʻo Simlo e hana maʻamau i nā hapa momona o ke koko. Hoʻokumu ke kumuhana o ka hopena o ka lāʻau Simlo i ka hiki o kāna mea nui i ka hoʻomake ʻana i nā kaʻina hana o kekahi i nā mea o ka mua o ka kolamu e kū nei i ka puʻuwai. ʻO ka normalization o ka hoʻolālā biochemical kekahi o nā mea nui e hōʻoli pono i ka holomua o ka atherosclerosis, kahi e hōʻemi nei i ka hopena o ka hoʻomohala ʻana i ka maʻi ischemic, a he mea maikaʻi loa ia e pale ʻia ai ke ʻano o ka myocardial infarction. Ke lawe ʻia, e hoʻomaka ka lāʻau lapaʻau i loko o ka pā liʻiliʻi. Pono e hoʻomaopopo ʻia ma o nā hoʻomaka mua o ka hōʻina o ka mea ikaika i loko o nā paia o ka pūpū. Ke hele nei ma loko o ka ate, ua loli ka hapa nui o nā huahana i kahi derivative. Nā hōʻailona no ka hoʻokomoLoʻo ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana:
Ka ʻae ʻana o nā kālāHoʻolohe Inā koi, hiki i ke kauka ke hoʻoponopono i ka dosis.
Pono e hāʻawi ʻia i ka lāʻau i ka mea maʻi ma mua o hoʻokahi i ka lā. Inā pono, e hoʻonui i ka dosage me ke ake ʻana o nā pule he ʻehā. ʻO ka dosage ʻokoʻa loa i hiki ke lawe ʻia i kēlā me kēia lā he 40 mg. Hāʻawi ʻia ka mea e lawe ʻia i ke ahiahi. I kēia hihia, hiki ke inu i ka lāʻau lapaʻau i ka wā e ʻai ana a i mua paha. No nā poʻe maʻi e loaʻa ana i ka immunosuppressants, ʻo ka mea i manaʻo ʻia, ʻelima mg i kēlā me kēia lā. ʻO nā maʻi i loaʻa i nā pōʻino hōʻeha a hōʻemi ʻia paha, ʻaʻole pono ka hoʻoponopono ʻia ʻana. Inā koʻikoʻi ka lesiona, a laila ʻaʻole pono nā maʻa mua o ka 5 mg i kēlā me kēia lā. I kēia hihia, he mea nui loa ia e hoʻomaʻamaʻa pinepine i kahi hoʻopaʻa lapaʻau maʻamau. Me kahi ʻoluʻolu o nā poho o ka ate, ʻaʻole pono hoʻi ke hoʻoponopono ʻana i ka lāʻau. Inā hōʻeha nui ka mea lanakila, a laila pono ʻo Simlo e haʻalele i ka lāʻau lapaʻau. No ka mālamaʻana iā IHD, kahi lāʻau lapaʻau i kuhikuhi ʻia i loko o kahi waihona o 10 mg. ʻAʻole ka hoʻonui ʻana o ka hoʻonui ʻia i kēlā me kēia lā i hoʻokahi manawa. ʻO ka nui ʻona e koi ʻia he 10 mg. ʻO ka hui pūʻana o nā kālā me nā lāʻauʻokoʻa'ē aʻe
Ke hui pū ʻia me nā anticoagulants kūpaʻa, hiki ke hoʻonui aʻe i ka hopena o ka hopena. Ke lawe ʻia me ka cholesterol, hoʻemi ʻia ka bioavailability o simvastatin. Inā pono e lawe i ʻelua mau lāʻau lapaʻau, a laila pono e lawe ʻia ʻo Simlo i nā hola 4 ma hope o ka lawe ʻana i ka cholestyramine. ʻO ka lāʻau Simlo mau manawa i hoʻonui i ke kahe o ka digoxin i loko o ke koko o ke kanaka. Nā hopena hopenaI kekahi manawa hiki i ke kino e pili ana i ka pane, hiki ke hōʻike iā ia iho i ka mea maʻi ma ke ʻano o nā hōʻailona like:
Inā hoʻomaka kēia mau hōʻailona e hōʻike, a laila e hoʻomaopopo koke i ke kauka. I ka wā hāpaiʻAʻole pono ka lā o kēia lāʻau lapaʻau i ka wā o ka hapai a me ka umauma, me ka Hiki ke hoʻomaka nā hopena kūlike ʻole e hoʻomohala ma ka pēpē.
Pono e hoʻoluʻolu ke keʻena a kēia lumi, ʻoluʻolu, aʻeleʻele hoʻi. Pono mālama ʻia ka lāʻau mai nā keiki a me nā holoholona punahele. Kuhi ʻia i nā ʻōlelo aʻoaʻo a pau, hiki ke hoʻohana ʻia ka huahana no nā makahiki ʻelua. Ke ʻae ʻia nei ka lāʻau i hala ua ʻalo ʻia, no ka mea pono wale kahi mea hana i kou kino i hoʻopilikia ʻia. Wahi a ka ʻāina, hiki ke loli ka nui o ka uku. Ma Lūkia mai ke kumukūʻai mai 275 a 390 mau rubles. I Ukraine ua hoʻoholo ʻia ke kumukūʻai ma 198, 57 hryvnia. I waena o nā mea hoʻohālikelike o kēia pono hana, hiki ke hoʻokaʻawale i nā mea hoʻohālike e like me Vazilip, Zovatin, Zokor, Levomir, Ovenkor, Simvakol, Simvastol, Simvagestal, Holvasim, Simplakor, Simvakard, Holvasim, Simvor, Sinkard, Simplakor, Simgal, like me nā ala ʻē aʻe. I ke kohoʻana i kahi analogue, pono pono ke kauka ke mālama i ka hiki kālā o ka mea maʻi, kona kūlana maʻamau, a me kahi mea e hiki ai ke kōkua i nā mea āpau. Ma waena o nā mea pōmaikaʻi, hiki ke hoʻokaʻawale ʻia kahi papa inoa o nā analogue. Eia kekahi, hoʻohanohano ka poʻe he nui i kahi ala hoʻokele, me ka uku haʻahaʻa. Ma nā ʻoluʻolu, nā maʻi e komo i ka contraindications a me nā hopena ʻaoʻao. Nā hopena hopenaMai ka pūnaehana hana ʻana: dyspepsia (pōhaʻi, luaʻi, gastralgia, ʻeha ʻeha, constipation a i ʻole nā lolo ʻana, ka lalo o nā maʻi), hepatitis, jaundice, ka nui o nā hana o ka "melamin" transaminases a me ka alkatine phosphatase, CPK, mahal - pancreatitis koʻikoʻi. Mai ka ʻōnaehana o nā nū a me nā kino sensory: asthenia, dizziness, headache, insomnia, convulsions, paresthesia, peripheral neuropathy, blurred vision, impaired flava. Mai ka pūnaehana musculoskeletal: myopathy, myalgia, myasthenia gravis, ʻaʻole loaʻa rhabdomyolysis. Alika a me ke ʻano immunopathological: angioedema, lupus-like syndrome, polymyalgia rheumatism, vasculitis, thrombocytopenia, eosinophilia, hoʻonui i ESR, arthritis, arthralgia, urticaria, photosensitivity, ʻomaʻeha, hyperemia o ka ʻili, ka holo ʻana o ka maka. ʻO nā hopena dermatological: rash skin, itching, alopecia. Other: anemia, palpitations, acute renal failed (ma muli o rhabdomyolysis), i hoʻemi ʻia ka potency. Nā ʻōlelo kikoʻīMa mua o ka hoʻomaka ʻana i ka mālama ʻana, pono e hana i kahi hōʻike ʻana o nā hana ʻalika (nānā i ka hana o ka "hati" transaminases i kēlā me kēia 6 mau wiki no ka 3 mau mahina mua, a laila ma kēlā me kēia 8 mau pule no ke koena o ka makahiki mua, a laila hoʻokahi i kēlā me kēia ʻeono mau mahina). No nā poʻe maʻi e loaʻa simvastatin i loko o kēlā me kēia lā o 80 mg, ʻike ʻia ka hana o ka ate i kēlā me kēia 3 mau mahina. I nā hihia i piʻi ai ka hana o nā transaminases "maʻa" (ʻoi aku 3 mau manawa o ka palena o ke kumu kūʻai). I ka poʻe maʻi me ka myalgia, myasthenia gravis a me / a me kahi hoʻonui nui ʻana o ka hana CPK, ua mālama ʻia ka mālama lāʻau. ʻO ka Simvastatin (a me nā HMG-CoA reductase inhibitors) pono e hoʻohana ʻia me ka nui o ka nui o ka rhabdomyolysis a me ka hana ʻole o ka renal (no ka maʻi nui o ka maʻi, ka maʻi arterial, ka hōʻoki nui, trauma, a me nā maʻi hoʻokūkū koʻikoʻi). ʻO ka wehe ʻana i nā lāʻau lapaʻau lipid-ka wā o ka hapai ʻaʻole iʻike koʻikoʻi i nā hopena o ka mālama lōʻihi ʻana o ka hypercholesterolemia mua. Ma muli o ka hana like ʻole o ka HMG-CoA reductase inhibitors ka pale ʻana i ka synthesis kolesterol, a me ka kolamu a me nā huahana ʻē aʻe o kāna synthesis he kuleana koʻikoʻi i ka hoʻomohala ʻana o ka pūpū, me ka synthesis o ke aʻa a me ka membranes cell, simvastatin paha i ka hopena ʻeha i ka ʻōpū i ka wā i kauoha ʻia ai i nā wahine hāpai. pono nā wahine o ka hānau hānau ʻana e hāpai pono i nā hana contraceptive). Inā kūpaʻa ka hānau ʻana i ka wā e mālama ai, pono e hoʻokuʻu ʻia ka lāʻau, a hōʻike ʻia ka wahine i ka pōpilikia i hiki i ka pūpū. ʻAʻole hōʻike ʻia ʻo Simvastatin i nā hihia i loaʻa kahi ʻano I, IV, a me V hypertriglyceridemia. He maikaʻi ia i ka ʻano o ka monotherapy, a me ka hui pū ʻana me nā sequestrants o nā waikawa bile. Ma mua a i ka wā o ka mālama ʻana, pono ka mea maʻi ma luna o ka ʻai hypocholesterol. I ka hihia no ka nalo ʻana i kēia ʻano o kēia manawa, pono e inu ʻia ka lāʻau lapaʻau. Inā hiki i ka manawa no ka hopena hou, mai pāpālua i ka nui. I ka poʻe maʻi me ka pilikia ʻole o ka hana ʻana, ke mālama ʻia nei ka hana ma lalo o ka mālamalama o ka hana ʻeha. Hoʻomaopopo ʻia nā mea maʻi e hōʻike koke i ka ʻehaʻeha o ka puʻuwai ʻole, lethargy, a i ʻole nāwaliwali, ʻoiai, inā i hui pū ʻia e ka malaise a i ʻole ke kuni paha. Me ka mālama ponoʻO nā mea maʻi e loaʻa ʻana i ka waiʻona a me nā poʻe maʻi e loaʻa ana i ke kaʻi ʻana o ke kino, e aʻo ʻia e hoʻomanawanui ma ka mālama ʻana iā Simlo me ka nui loa.
Pono e mālama pono ʻia ʻo Simlo i nā maʻi me nā mea kani a ke ʻūlū, me ka epilepsy a i ʻole nā mākeke e lawelawe ʻole ʻia. Ma ke alo o kekahi o nā mea i kākau inoa ʻia, e hōʻike ʻia nei e lawe i kēia lāʻau lapaʻau wale nō e like me ka kauoha a ke kauka.
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ʻO nā hiʻohiʻona Pharmacokinetic kahi paʻa paʻa loa i ka mucosa gastric ina lawe ʻia. ʻO ka Biotransformation a me ka metabolism o ka simlo e hele i loko o ka ate. Hoʻokumu ʻia nā metabolites koʻikoʻi ma laila, ʻo ia ka beta-hydroxymetabolites. ʻO 95% o lākou e nakinaki ai i nā ʻōmole o ka protein i ke koko.
Me ka hypercholesterolemia, pono ʻole ka nui o ka nui ma mua o 5 mg / lā. Me ka pīhoihoi ikaika i ka kolamu ma ke koko, ua ʻōlelo ʻia ka lāʻau lapaʻau ma ke ʻano o 10 mg.
Me ka hoʻomohokoke ʻana o Simplo me ka cyclosporine, gemfibrozil, erythromycin a i loko o ka nicotinic acid, ʻoi ka hopena o ka rhabdomyolysis i mau manawa.
Pono e hoʻonā ʻia ka lāʻau lapaʻau ma kahi o kahi kiʻekiʻe e ka nui o ka 25 kiʻekiʻe.
