Rosuvastatin: nā ʻōlelo i hoʻohana ʻia ai, nā ʻōkuhi a me nā loiloi

ʻO ka wehewehe e pili ana i 18.07.2014

• Palapala Latin: Rosuvastatin
• Manaʻo SAX: C10AA07
• Mea waiwai: Rosuvastatin (Rosuvastatin)
• Mea Hana: CANONPHARMA, Rusia

Kahi ʻia ka pālani āpau. ʻO ka mea nui rosuvastatin.

• ʻano keʻa mahina
• konekena stearate,
• mikuleka
• povidone
• calcium hydrogen phosphate dihydrate.

ʻO ka hoʻonohonoho ʻana o ka ʻāpana film:

• selika AQ-01032 ulaula,
• titanium hone
• haniailahion,
• macrogol-400,
• macrogol-6000.

Mamuli o ka dosage (10 mg, 20 mg, 40 mg), ua loli ke ʻano o ka papa.

Nā hōʻailona no ka hoʻohana ʻana

Pono ka lāʻau Rosuvastatin e lawe ʻia:

• ma hypercholesterolemia (me ka hoʻohui ʻana o ka meaʻai i mea ʻole ke ʻano o nā lawelawe ʻē aʻe).
• ma hypertriglyceridemia (me ka hoʻohui ʻana o ka meaʻai).

Nā Hoʻohui

Ua hoʻohālikelike kēia lāʻau lapaʻau i nā poʻe me ka hypersensitivity i nā mea o ka lāʻau.

Eia kekahi, ʻo nā maʻi e pili ana i kēia mau contraindications e lawe i ka lāʻau kūlohelohe mua:

I o ka hāpai ʻana a hana waiū ua kahakaha ʻia hoʻi ka lāʻau.

Noi ʻia ka mālama ʻana e inu i kēia lāʻau lapaʻau i nā poʻe me ka:

• sepsis,
• i ka wā o ka hōʻiliʻili o ka maʻi,
• ma ka hoʻonāʻana o endocrine,
• me nā mea hōʻeha.

Pono hoʻi ʻoe e makaʻala i ka hoʻohana ʻana iā Rosuvastatin i nā ʻelele o ka lāhui Asian.

No nā kānaka ma lalo o ka 18 a ma hope o 65 mau makahiki, ʻaʻole ʻia kēia lāʻau lapaʻau.

Nā hopena hopena

He loaʻa i ka lāʻau lapaʻau ka palahalaha o nā hopena ʻaoʻao hiki ke kumu.

ʻŌnaehana musculoskeletal:

Pūnaehana pōkole:

Pūnaehana huhū:

ʻŌnaehana urinary:

• nā hopena maʻi
• ʻeha i ka ʻōpū ma lalo.

ʻAstlelo Gastrointestinal:

Laha Uila:

Hoʻohui

Hoʻokomo ʻia hiki ke lawe wale ʻia ma hope o kekahi manawa (ma kahi o 2 mau hola) ma hope o ka lawe ʻana i kēia lāʻau lapaʻau, ʻoiai ko lākou hoʻohana ʻana e alakaʻi i ka kahe o ke kao o Rosuvastatin.

Erythromycin ʻaʻole hoʻi e lawe ʻia me ka rosuvastatin, no ka mea i ka hopena o ka lawe ʻana i nā lāʻau lapaʻau he emi iho.

Kauhi Pani

Hoʻonaʻauao: Ua puka mua ʻo ia mai ka Rivne State Basic Medical College me kahi kekelē ma Pharmacy. Ua puka 'o ia mai ke Kulanui Kaukaʻi ʻo Vinnitsa State. M.I. Pirogov a kahi hui honua e hoʻokumu ʻia ai.

Aio: Mai 2003 a 2013, hana ia i ka ʻoihana lapaʻau a me ka luna o ke kiʻina lāʻau lapaʻau. Hāʻawi ʻia ʻo ia i nā leka a me nā hōʻailona no nā makahiki he nui o ka hana naʻauao. Ua paʻi ʻia nā ʻatikala e pili ana i nā kumuhana maʻi i nā nūpepa kūloko (nūpepa) a ma nā palapala pūnaewele.

No ka mea ʻaʻole i kiʻekiʻe ka triglycerides i kahi kiʻekiʻe koʻikoʻi, ʻaʻole wau e aʻo i ka rosuvastine, nui nā hopena maikaʻi, ʻaʻole pono ke pāʻani i ke kukui, pono wau e hoʻopiʻi. I kēia manawa ke hoʻolohe aku nei au i ka dibikor, maʻamau LDL a me HDL, he ʻoluʻolu aʻoluʻolu hoʻi, akā maikaʻi hoʻi. ʻLelo, inā ʻaʻole hiki ʻole iā ʻoe ke hana me ka ʻole o statin, ʻoi aku ka maikaʻi o ka hoʻopili ʻana i ka dibicor e hōʻemi i nā hopena ʻaoʻao, i ʻōlelo mai ai ke kauka iaʻu.

Lawe wau i kahi mea hoʻohālike o kēia lāʻau lapaʻau, kapa ʻia ʻo ia iā Rosuvastatin-SZ. Ua kākau aku kekahi ma ka maʻi maʻi iā ia no ka manawa lōʻihi, i ka pale ʻana i ka hōʻeha ʻana o ka puʻuwai, ua hoʻopiʻi ʻia ʻo ia me nā hana o ka hoʻohaʻahaʻa ʻana i ka cholesterol maikaʻi, a hoʻemi ʻia ia mai 7.9 a 5.5 mau hapalua o ka makahiki. Kuhi pinepine lākou e pili ana i nā hopena ʻokoʻa, akā pilikino iaʻu ʻaʻohe mea e like me kēia.

Hoʻomili hou a me ke ʻano hoʻohālikelike

No ka Rosuvastatin i ka hopena lipid-e hoʻohiolo i ka pūʻulu statin. Pūlele haʻahaʻa - HMG-CoA inhibitors. Ma muli o kēia hana lāʻau lapaʻau, hoʻemi ka mea intracellular o ka lipids, ua hana ka hana o nā receptors no nā molekela LDL e uku, a ʻo ka hopena, ka catabolize wikiwiki a hoʻopuka ʻia mai ka kahe o ke kahe. Eia kekahi, e like me nā statins ʻē aʻe, ua loaʻa i ka rosuvastatin kahi hopena ma ka endothelium, ke kāohi nei i kona ʻano (ʻohiʻohi i ka hoʻomohala ʻana o ka atherosclerosis mua i ka laʻa preclinical), ma ka pā vascular (pale iā ia mai ka palaka ʻoi i ka cholesterol). Main hikiwkomo i ka hana rosuvastatin - CYP2C9

ʻO ka hoʻokuʻu i ka puka rosuvastatin he papa. ʻOleʻele lākou i ka'āpana, convex ma nā ʻaoʻao ʻelua, uhi ʻia me kahi kiʻiʻoniʻoni. I ka hewa, ua pili nā mea kumu o loko o ke keʻokeʻo a keʻokeʻo. ʻO ka mea hana nui ma ka papa - kalepona rosuvastatin - loaʻa i 5 mg, 10 mg a me 20 mg. Wahi a ka maʻi maʻi, ʻokoʻa ka ʻano o nā papa. ʻO ka palapala kiko o nā koho dosage no ka mea ikaika e 5 mg a me 20 mg, ʻo ka elongated form he 10 mg a 40 mg.

I loko o nā lāʻau lapaʻau, hiki iā ʻoe ke kūʻai i nā kīʻaha pepa a me nā bloses o 6, 10, 14, 15 a i 30 mau papa i kēlā me kēia, i hilinaʻi ʻia, a i ʻole 30 a 60 mau ʻāpana i loko o nā ipu. I ka hoʻohui i ka mea nui (i ka ʻoiaʻiʻo, rosuvastatin - ke ʻano o ka inoa inoa honua), ʻo ka hui pū ʻana o ka lāʻau lapaʻau ka nui o nā mea hou aku: povidone, mais kōpau, magnesium stearate, microcrystalline cellulose. Ka hoʻonohonoho ʻana o ka pūpoki i kahi hui maloʻo: talc, macrogol, titanium dioxide, hao oxide (ʻulaʻula). Mālama i ka mea hana, ʻano liʻiliʻi.

Ma luna, ua nānā mākou i ka hoʻopili ʻana o ka mea hana kumu rosuvastatin Canonpharma (ʻāina - Russia). I kēia lā hoʻi e noʻonoʻo mākou i nā mea hoʻohālike o kēia lāʻau lapaʻau e like me ka lāʻau radar (hoʻopaʻa inoa i nā lāʻau lapaʻau), a e hoʻoholo i ka mea hana ma nā papa lāʻau lapaʻau he ʻoi aku ka maikaʻi ma ke kumukūʻai a me ka maikaʻi.

Nā hopena hopena

Kumuhana i nā noiʻi lapaʻau i kauoha ʻia i nā lā a pau o ka lāʻau lapaʻau, rosuvastatin e hoʻopuka i nā hopena ʻaoʻao. Inā ʻaʻole, me ka mālama pono ʻole, hiki i ka lāʻau lapaʻau ke lawe mai i ka pono a me ka pōʻino. Hoʻomaopopo ʻia ka mea e pili ana i nā hopena ʻokoʻa e like me ka helu ʻana o ka WHO (WHO): pinepine pinepine, i kekahi manawa, i ka manawa hihia, ka hihia, ʻike ʻole, ʻokoʻa keʻokeʻo. ʻĀnō e nānā mākou i nā mea kūpono i ke ʻano a pono e noʻonoʻo pono i kēia lāʻau lapaʻau.

• ʻO nā maʻi hoʻoponopono pilikino: ka hoʻomohala ʻana o ka non-insulin-depend-diabetes mellitus (DM) type 2.
• ʻO ka maʻi a me ka reactivity maʻi: hopena hypersensitivity, urticaria, edema.
• CNS - ʻeha i ke poʻo, dizziness.
• Nā kinona a me nā mea hana pelekane - ʻehaʻeha o ka naʻau (myalgia), myopathy, rhabdomyolysis ma muli o ka maikaʻi ʻole o ka renal, i nā hanana koʻikoʻi loa (1 i 10,000) - nā pehu aoprotizing meopathy. Kēia - arthralgia, myositis. He mea koʻikoʻi ia kia nānā i ka pae o ka hana a ka enzyme phosphokinase enzyme a me ka piʻi nui ʻana i ka ʻike (ʻelima mau manawa a i ʻole ʻoi aku kēia waiwai) ua hoʻopau ʻia ka mālama ʻana me ka rosuvastatin.
• Nā maʻi gastrointestinal - ʻeha o ka ʻōpū, constipation, nausea.
• Pūnaehana urinary - kahi protein i loko o ka urine (proteinuria), maʻa mau ke kau ʻana i ka wā o ka mālama ʻana a ʻaʻole ia he mākaʻina o kekahi ʻano maʻi renal koʻikoʻi.
• ʻO ka ʻili a me PUFA - nā kala, urticaria, erythematous rash.
• Haki - kahi loli e hilinaʻi ana i ka dosis i nā enzyme o ka naʻau - transaminases a me nā hoʻonui hou aʻe i loko o lākou.
• Nā ʻāpana Laboratory - bilirubin, phosphatase alkaline, gamma-glutamintranspeptidase hana e hoʻonui, i nā hihia loaʻa, i nā hoʻopiʻi hoʻopiʻi ʻana mai ka umauma thyroid.
• ʻO nā hōʻailona ʻē aʻe he asthenia.

Hoʻomaʻo pinepine nā poʻe maʻi i ka nīnau - e hoʻonui paha ka mahana i ka wā e lawe ana i ka rosuvastatin? ʻAʻole, ʻaʻole ia. Makemake wau makemake i ka ʻike ʻole i ka hoʻohālikelike ʻana me nā statins me ka waiʻona, no laila, e hōʻea nā mea maʻi i ka inu ʻona i ka wā o ka mālama ʻana, inā ʻaʻole hiki ke loaʻa nā hopena kūpono i kekahi mau manawa, a ʻo ka pono hiki, ʻehā, ʻaʻole.

Nā ʻōkuhi no ka hoʻohana

ʻO ka maʻamau, ʻo ka maʻi ma mua o ka rosuvastatin he 5-10 mg i kēlā me kēia lā, e kau ana i nā pahuhopu o ka mālama a me ke ʻano maʻamau o ka mea maʻi a me kona kino. Ma mua o ka hoʻomaʻamaʻa ʻana, pono e mālama ʻia ka hana ʻana eʻai ai i ka hoʻohaʻahaʻa i ka kolamu koko. Pehea lawe pono rosuvastatin?

Hiki ke inu i ka lāʻau lapaʻau e pili ana i ka meaʻai, koke ke ʻano o ka papa holoʻokoʻa i kauoha ʻia no kēlā me kēia manawa. Mai hoʻokaʻawale i ka papa papaʻa, mai hoʻomoʻi a kuʻalapa hoʻi, a lawe ma ke ʻano me he ʻano holoʻokoʻa, me kahi aniani wai. Koho ʻia ka Dosage no kēlā me kēia. Inā pono, ma hope o nā hebedoma ʻehā, hiki i ke kauka komo ke hoʻonui i ka hopena e loaʻa ai ka hopena e makemake ai.

Ke koho i ke koho ʻana i kahi laʻana i kēlā me kēia lā he 40 mg, nui ka hoʻonui ʻia ʻana o ka hopena ʻino, no laila ke hāʻawi ʻia nei kēia nui o ka lāʻau lapaʻau no nā maʻi nui o ka hypercholesterolemia a me ka hopena kiʻekiʻe o ka hoʻopiʻi ʻana mai ka ʻōnaehana vascular a me ka puʻuwai, inā ʻaʻole i hāʻawi ka hopena o 20 mg i ka hopena i manaʻo ʻia ma mua. Pono e hoʻokō i ka nānā kānāwai mandid metabolism ma hope o 2-4 mau wiki mai ka hoʻomaka ʻana o ka hopena aʻoaʻo a i ʻole ka piʻi o ka hana ma loko.

Inā loaʻa i ka mea maʻi ka maʻi concomitant mai loko mai o ka lolo, ate, musculoskeletal system, kahiʻano maʻamau i ka myopathy, a laila ʻo ka palapala i kauoha ʻia no 5 mg kēlā i kēia lā. ʻĀnō e hōʻike i ka lōʻihi o ka lawe iā rosuvastatin. Hoʻomaʻamaʻa ʻia ke ʻano o ka mālama ʻana i kēlā me kēia, akā ʻo ke kaukani ʻo ia ma kahi o hoʻokahi mahina.

Hoʻohana i ka wā hāpai

E like me nā statins ʻē aʻe, ʻaʻole i ʻae ʻia ʻo rosuvastatin i ka wā hāpai a me ka lactation.

ʻO nā makahiki o nā keiki kekahi o nā contraindications o rosuvastatin. ʻAʻole nō ʻia kahi noiʻi piha piha e pili ana i ka hopena ma luna o ke kino o nā keiki, no laila ʻaʻole hoʻohana ʻia kēia statin i loko o ka hana hoʻomehana.

Ka lāʻau kūʻai lāʻau

No nā maʻi he nui, he hoʻohui i ka maikaʻi a me nā hopena o ka lāʻau lapaʻau, aia i kona kumukūʻai i kahi wahi nui. No ka rosuvastatin, hoʻohālikelike ʻia ke kumukūʻai me nā kumukūʻai o nā lipid-hoʻohaʻahaʻa ʻē aʻe. Ehia ka uku o ka rosuvastatin? Wahi a ka ʻāina, like like ke kumukūʻai. Ma Lūkia ma Moscow kūʻai lāʻau kūʻai, ua kūʻai ʻia nā lāʻau ma nā kumukūʻai i lalo aʻe:

• no 30 mau papa o 5 mg - kumukūʻai mai 510 mau rubles
• no 30 mau papa o 10 mg - kumukūʻai mai 540 mau rubles
• no 30 mau papa o 20 mg i kēlā me kēia - kumukūʻai mai 850 mau rubles

I Ukraine hoʻemi nui nā kumukūʻai rosuvastatin. Aia nā kumukūʻai i loko o nā mākeke ma Kiev ma loko o nā pahu i kākau ʻia:

• no na pcs 28. 5 mg kēlā me kēia - kumukūʻai mai 130 UAH
• no na pcs 28. 10 mg kēlā me kēia - kumukūʻai mai 150 UAH
• no na pcs 28. 20 mg i kēlā me kēia - kumukūʻai mai 230 UAH.

ʻO kaʻoiaʻiʻo, hilinaʻi nā kumukūʻai i ka ʻoihana mea hana, nā ʻano o nā kaulahao a me nā kulekele kumukūʻai kūikawā o nā wahi pilikino i loko o ka'āina.

Nā Hōʻike Hoʻohana

Ma waena o nā limahana lapaʻau, loiloi ka loiloi o nā rosuvastatin. Ua manaʻo ʻia he lāʻau lapaʻau hou o ke koho no ka hypercholesterolemia me kahi kumukūʻai maikaʻi / maikaʻi. Hoʻomaʻo pinepine ʻia e mālama i ka atherosclerosis. Ma ka hoʻomau ʻana i ka pae lipid, ua hoʻemi ʻia ka hopena o ka hōʻeha ʻana o ka naʻau a me nā hōʻeha.

Petrenkovich V.O. Kauka i ka hoʻomaʻamaʻa ʻohana o nā makana kiʻekiʻe loa, ʻo Vinnitsa: “Ma ka hoʻomaʻamaʻa hoʻomaʻamaʻa ʻana, ua hoʻohana wau i ka rosuvastatin no kekahi manawa a me nā manawa pinepine. No nā maʻi maʻi, makemake wau e kahakaha ʻana ʻo ia ma ke ʻano he Roxer. I nā kūlana āpau, ʻike wau i kahi hopena lapaʻau maikaʻi. ʻAʻole hoʻopiʻi ka poʻe maʻi i nā hopena ʻino, ua hoʻomanawanui maikaʻi ʻia ka lāʻau. ʻOi ka momona i ke kumukūʻai "

ʻOiai ka hapanui o ka makaʻu ʻana o ka poʻe i ka papa inoa o nā hopena i hiki ke lawe i ka rosuvastatin, ma waena o ka poʻe e lawe nei ʻaʻole i kākau i kekahi mau huaʻōlelo maikaʻi ʻole. ʻO ke kumukūʻai a me ka hopena i manaʻo ʻia e lawe ana i ka rosuvastatin e hōʻoia i kona kumu.

Gorelkin Pavel, Novorossiysk: "No kekahi mau makahiki i kēia manawa, ua ʻōlelo mai nā kauka he nui kaʻu kolamu. I kaʻu makahiki 42, makaʻu nui wau i ka make mai kahi hōʻeha hōʻeha. Ma ka halemai apana, ua kuhikuhi ʻia e hoʻomaka i ka inu ʻana iā Suvardio. Ma hope o hoʻokahi mahina a me ka hapa, ua hoʻomaikaʻi nui kaʻu mau ho'āʻo ʻana, ua ʻoi aku ka maʻalahi ma koʻu ʻuhane. He aha ke kumukūʻai? ʻĀ, ʻokoʻa ke kumukūʻai ʻole nui, no laila hiki iaʻu ke kūʻai. E hoʻomau wau i ka mālama "

Belchenko Z.I., 63 makahiki, kauhale. Akhtylsky: “No nā makahiki he nui wau i ka mālama ʻana i kaʻu kolamu kiʻekiʻe me ka hoʻoponopono ʻana o nā kānaka. ʻO nā mea aʻu e hoʻāʻo ʻole ai, ʻaʻohe mea kōkua iaʻu. I ka makahiki i hala aku nei, ua ʻōlelo mai kekahi hoalauna iaʻu e ʻike i kahi kauka hou i ka haukapila. Ma laila wau i kauoha ʻia ai iā rosuvastatin. Ua haʻi ʻia mai iaʻu i kēia lāʻau lapaʻau hou a maikaʻi loa. ʻOiai ke kumukūʻai nui loa ke kumukūʻai noʻu, ʻo nā kumukūʻai ke kumukūʻai, akā ke inu nei wau iā ia no hoʻokahi makahiki i kēia manawa a loaʻa iaʻu kahi kolamu maʻamau. "

Makashvili O.B., mau makahiki 50 a keu ʻo Kerch: "Ma ke aʻo a kona kaikaina, hoʻomaka ʻo Tevastor e lawe. Ua hōʻiliʻili ʻia koʻu maʻi maʻi. Hele wau i ke kikowaena, kahi i hoʻohuli ai lākou i ka lāʻau lapaʻau me kekahi lāʻau lapaʻau ʻē aʻe, akā ma ka aneane like. Ka mea, ʻaʻole pono e lawe ʻia ʻo Tevastor me ka maʻi maʻi. "

E like me kāu e ʻike ai, e like me nā loiloi o nā kauka a me nā mea maʻi, ua loaʻa iā rosuvastatin kahi kumukūʻai maikaʻi / maikaʻi uku. ʻO Rosuvastatin kahi lāʻau lapaʻau hou a me ka pono. Me ka hoʻokomo paʻa ʻana i nā ʻōlelo lapaʻau, ua loaʻa ia i kahi hoʻolaha kiʻekiʻe a hiki ke kuhikuhi ʻia he papa lōʻihi.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

Hoʻohana ʻia ka lāʻau lapaʻau Rosuvastatin i ke ʻano o nā papa, papa ʻaina ʻoniʻoni no ka hoʻokele waha (waha). He ʻulaʻula kukui a i ʻole paha i ka kala kala, nā ʻāpana a me ke ʻano biconvex.

Kahi ʻia ka pālani āpau. ʻO ka mea nui rosuvastatin.

• ʻano keʻa mahina
• konekena stearate,
• mikuleka
• povidone
• calcium hydrogen phosphate dihydrate.

ʻO ka hoʻonohonoho ʻana o ka ʻāpana film:

• selika AQ-01032 ulaula,
• titanium hone
• haniailahion,
• macrogol-400,
• macrogol-6000.

Mamuli o ka dosage (10 mg, 20 mg, 40 mg), ua loli ke ʻano o ka papa.

Ka hana lāʻau lapaʻau

ʻO Rosuvastatin he aila lipid-hoʻohaʻahaʻa, he mea pale i ka mea hoʻokūkū koho hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, ʻo ia ka hoʻoneʻe e hoʻololi i ka 3-hydroxy-3-methylglutaryl CoA i ka mea mua o ke kolamu - mevalonate. Hoʻonui ka lāʻau i ka nui o nā receptors LDL (lipoproteins haʻahaʻa haʻahaʻa) ma ka ʻaoʻao o nā pūpū o nā pupu, nā hopena me ka hoʻonui ʻana i ka catabolism a me ka piʻi ʻana o LDL a me ke ʻano o ka VLDL (haʻahaʻa lipoproteins haʻahaʻa) i hoʻokuʻu ʻia. I ka hopena hope, ua hōʻemi ʻia ka nui o ka VLDL a me LDL.

Ma lalo o ka hana a Rosuvastatin, ua hoʻonui ʻia ka ʻike ʻana o OXC (ka nui o ka cholesterol), ka cholesterol-LDL (lipoproteins haʻahaʻa haʻahaʻa), ʻo TG (triglycerides), ApoB (apolipoprotein B), hōʻemi ʻia ʻo TG-VLDL a me VL-VLDL. Hoʻonui ka lāʻau i ka piʻiʻana o HDL-C (HDL cholesterol) a me ApoA-I (apolipoprotein A-I). Hoʻopili ʻo Rosuvastatin i ka index atherogenicity, e hoʻomaikaʻi ana i ka ʻōlelo lipid i nā mea maʻi me ka hypercholesterolemia.

Hoʻokumu ka hopena therapeutic o ka lāʻau i ka hebedoma mua ma hope o ka hoʻomaka ʻana o kāna hoʻomalu, a hiki i ka hopena kiʻekiʻe o ka wiki ʻehā o ka papa.

Lapaʻau lāʻau

ʻO ka lōʻihi loa o ka plasma wela o ka hana ikaika e hōʻea i mau hola 5 ma hope o ka lawe ʻana iā Rosuvastatin. ʻO ka bioavailability piha loa ma kahi o 20%.

Lawe ʻia ka papa hana nui e ka pepeka. ʻO ka nui o ka hoʻoilina he 134 lita. Ma kahi o 90% o ka waiwai e hoʻopili ai i ka protein plasma (ʻoi aku paha me ka albumin). ʻO nā metabolites koʻikoʻi ka metabolite lactone (ʻaʻohe hana lāʻau lapaʻau) a me N-desmethylrosuvastatin (50% ʻaʻole ikaika i ka rosuvastatin).

Ma kahi o 90% o nā nui i lawe ʻia ma ke kēkē i loli ʻole, ke koena o nā keiki. ʻO ka hapalua o ka plasma he 19 mau hola.

ʻO ke kūlohelohe o ka pharmacokinetics o rosuvastatin he kūʻokoʻa o ka wahine a me nā makahiki o ka mea maʻi.

I nā kānaka o ka lāhui Mongoloid, he piʻi ʻelua o ka nui o ka plasma kiʻekiʻe o rosuvastatin a me ke median AUC (wahi ma lalo o ka kukuhi-manawa) i hoʻohālikelike ʻia me nā mea maʻi Caucasoid, ma India e piʻi ka nui o ka plasma plasma a me ka hoʻonui ʻana o ka AUC e hoʻonui i nā manawa he 1.3, i nā mea ʻelele o ka lāhui Negroid ua like nā ʻāpana pharmacokinetic me nā poʻe no Caucasians.

ʻO ka palupalu a i ka hoʻololi ʻana paha i ka hopena o ka renal i hopena ʻole i ka hopena o ka neʻe o ka rosuvastatin a me kāna metabolite N-desmethylrosuvastatin. I loko o ka maikaʻi o ka renal nui, piʻi ke kahe o ka rosuvastatin e like me ʻekolu manawa, a me N-desmethylrosuvastatin e ʻeiwa mau manawa. I ka poʻe maʻi ma ka hemodialysis, ʻo ka piʻi ʻana o nā mea ikaika e pili ana i ka 50% kiʻekiʻe.

I nā maʻi me ka maʻi hepatic koʻikoʻi, hiki i ka hapa hapalua o ka rosuvastatin ke hoʻonui i ka liʻiliʻi a ʻelua.

Kūkākūkā i ka wā hāpai a me ka lactation

ʻO Rosuvastatin a me nā statins ʻē a contraindicated ma kahi hāpai. Aia ma laila mau hōʻike hōʻike i kēia lāʻau lapaʻau e hoʻopilikia i ka hoʻomohala ʻana o ka pūpū, hoʻonui ʻia ka hopena o nā mea e kuhi ai i nā keiki hou. Pono nā wahine o nā makahiki hānau i ka statins e hoʻohana pono i nā ʻoihana kūpono o ka contraception.

Inā hele ʻole ʻia kahi hapaha hoʻolālā ʻole, a laila e kāpae i nā peni no ka cholesterol ke kū koke. ʻAʻole ia i kuhikuhi ʻia i ka hānai umauma i ka manawa o ka mālama me kēia lāʻau.

Dosis a me ke ala o ka hoʻokele ʻana

E like me ka hōʻike ʻana i nā ʻōkuhi no ka hoʻohana ʻana, lawe ʻia ka rosuvastatin, mai walaʻa a pala ʻole i ka papa, ʻai i ka piha, holoi ʻia me ka wai. Hiki i ke lāʻau lapaʻau ke kuhikuhi i kēlā me kēia manawa o ka lā, me ke ʻano o ka manawa o ka ʻai.

Ma mua o ka hoʻomaka ʻana i ka maʻi me Rosuvastatin, pono e hoʻomaka ka mea maʻi e hahai i ka maʻamau hypocholesterolemic diet a hoʻomau ma muli o ia i ka wā e mālama ai. Pono ke koho o ka lāʻau lapaʻau e koho kuokoa i ka pahuhopu o ka lāʻau a me ka pane therapeutic i ka mālama ʻana, me ka noʻonoʻo ʻana i nā loiloi o kēia manawa i nā piliona lipid.

• ʻO ka papa hana i hoʻomaka ʻia no nā maʻi e hoʻomaka ana e lawe i ka lāʻau lapaʻau, ai ʻole no nā mea maʻi i hoʻihoʻi ʻia mai ka lawe ʻana i nā HMG-CoA reductase inhibitors, pono 5 a 10 mg paha o ka lāʻau Rosuvastatin 1 mau manawa / lā. Ke koho ʻana i kahi pualikoa mua, pono ke alakaʻi e ka ʻikepili o kēlā me kēia lā e noʻonoʻo a hiki i ka hopena kūpono paha o nā hihia cardiovascular, a he mea pono hoʻi e nānā i ka hopena kūpono loa o nā hopena ʻaoʻao. Inā kūpono, hiki ke hoʻonui ʻia ka momona i ka nui ma hope o nā hebedoma 4 (e ʻike i ka ʻāpana "Pharmacodynamics").
• Ma muli o ka hiki ke hoʻomohala ʻana i ka hopena o ka hopena inā ke kaomi ʻana i kahi dosis o 40 mg, hoʻohālikelike ʻia me nā wai haʻahaʻa o ka lāʻau (e nānā i ka ʻāpana "ʻaoʻao sisihʻi"), e hoʻonui ana i ka dosis i 40 mg ma hope o ka nui o ka hopena hou aʻe ma mua o ka hopena i ʻōlelo ʻia ʻia no 4 mau pule hiki ke hoʻokola wale ʻia ʻo ia i nā maʻi me nā maʻi hypercholesterolemia a me ke koʻikoʻi o nā maʻi cardiovascular (ʻoi aku hoʻi i nā poʻe maʻi me ka hypercholesterolemia familial) ʻaʻole i loaʻa i ka hopena makemake e loaʻa ai ka hopena i ka wā e lawe ana i ka pā 20 mg, a ʻo wai lā e makemake ai? , t ia ma lalo o ka hooponopono ana o ka hoʻomalu (e nānā. pauku "Special ao"). ʻAno ke kiaʻi ʻana i ka poʻe maʻi e loaʻa i ka lāʻau lapaʻau ma loko o kahi mīkala o 40 mg.

ʻAʻole kōkua ʻia kahi dosage 40 mg no nā maʻi ʻaʻole i kūkā ma mua i kahi kauka. Ma hope o he 2 mau hebedoma o ka lapaʻau a me / a me ke kiʻi ʻana o ka nui o ka mahele o Rosuvastatin, ka nānā ʻana o ka lipid metabolism e pono (hoʻoponopono ʻia ka hoʻoponopono ʻana inā pono). ʻAʻole kūpono ke hoʻohana ʻana i ka lāʻau i loko o kahi kiʻekiʻe iʻoi aku ma mua o 40 mg i ka pili me ka hoʻonui ʻana o nā hopena hopena a i nā nui nui, ʻaʻole i hōʻike ʻia.

1. Me ka hana hoʻopihapiha creatinine o 30-60 ml / min, ua kuhikuhi ʻia ʻo Rosuvastatin i kahi hopena mua o 5 mg. ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau i kēlā me kēia lā he 40 mg ua contraindicated. ʻO ka mea maʻi me ka cleinine clearance e emi iho ma mua o 30 ml / min, me i ka hopena o nā maʻi o ka ate ma ka hana ikaika, ʻaʻole i kuhikuhi ʻia.
2. ʻO ka papa hoʻomaka ʻia i hoʻomaka ʻia no nā poʻe maʻi o ka lāhui Mongoloid he 5 mg. Ma kahi hapa o 40 mg, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau no kēia pūʻulu o nā maʻi.
3. No ka poʻe maʻi e lawe ana i ka genotypes c.521SS a i s.421AA, ka nui o ka paipai i kēlā me kēia lā o Rosuvastatin he 20 mg.
4. I nā hihia o kahi predisposition i ka hoʻomohala ʻana i ka myopathy, ʻo ka nui hoʻomaka ʻia ka dosis ʻo 5 mg, ʻo ka nui ka 20 mg.
5. Ke koho nei i kahi hui hoʻohui, pono e loiloi i ka hopena o ka hoʻomohala ʻana i ka myopathy.

Loaʻa ka hopena

ʻO nā hanaʻino i mālama ʻia i ka wā o ka maʻi maʻamau e kūlike a hilinaʻi ʻole ia a hele a lele ma kā lākou iho.

Hiki i nā hopena ʻino (> 10% - pinepine pinepine,> 1% a me 0.1% a me 0,01% a me Sasha. Ua hōʻike ʻo Therapist iaʻu me ka rosuvastatin 1 pākahi i hoʻokahi pō. a laila me ka hana nui ʻana, ʻānō e hana ana i ke kūpaʻa a make au i ka inu ʻana a ua pau kēia mau naʻau ʻokoʻa. Heluhelu wau i nā kauoha e haʻi ana lākou i ka ʻōnaehana cardiovascular ma ke ʻano he mea inu pono ʻole wau e inu.

Nui a lāʻau lapaʻau i loaʻa ka like me nā mea ikaika e like me ka rosuvastatin, a no laila hiki ke lilo e like me nā koho hou. Eia nō naʻe, ma mua o ka hoʻohana ʻana iā ia, e ʻae ʻia e kūkākūkā me kāu kauka.

Hoʻopili kēia mau mea:

Ma mua o ke kūʻaiʻana i kahi analog, e kamaʻilio i kāu kauka.