Agapurin: nā ʻōlelo aʻoaʻo no ka hoʻohana, nā loiloi

ʻO Agapurin ʻo antispasmodictherapeutic agent a lilo i hui huikala. ^ E Ha yM. Hoʻolaha palekezilamanaʻo e hoʻomaikaʻi i nā pono rheological koko a loaa ka microcirculation. ^ E Ha yM. Kaipuaoa palʻaihopezila hōʻike ʻia ma muli o kona hiki ke pani ʻia phosphodiesterasea hoʻonui i ka paʻa ATPi loko ʻāwili koko ʻōwilia cAMPi loko pā helu plateletme ka hoʻopiha kūlike ikehu ikaika. ^ E Ha yM. Ke alakaʻi nei kēia hana i ka hiki ke nānā aku hoʻopiha, kahi emi o ka pale ʻana o nā moku peripheral, he hoʻonui i ka minuke a me ka haʻalulu he pili koko a hele aku me nā loli ʻole ʻAne hoihoi.

Pentoxifyllinepili nui ka maʻi nā kīʻaha momoli a nā mea kani coronary, ma laila e hoʻonui ai i ka hāʻawi ʻana i ka hāhaʻe i ka kahe a me ka puʻuwai naʻau (antianginal hana) a hoʻonui i ke kani o nā ʻōpū o ka ʻōpū o ka ʻōpū (diaphragm a me nā ʻiʻo intercostal). Ma ka hihia o ka hoʻomaka palʻaihopezilai ka ulu ana i makai intravenously kaʻili paʻa a mahuahua ka pili kokoka hele ʻana ma ka pae o ka pauku. I loko o ka lolo e ulu ai ka manaʻo ATPa me ka hoʻonui ʻana i ka hana bioelectric o ka pūnaehana poʻomanaʻo. Hoʻopau koko lahilahi a mahuahua elasticity pale o erythrocyte (ma muli o ka hopena o ka lāʻau ma ke pathologically deformed ʻāwili koko ʻōwili) Ma nā wahi e piʻi ai ke kaʻe o ka pōʻino microcirculation. ^ E Ha yM. Me nā claudication intermittent, hoʻonui ka nui o ka huakaʻi hele, me ka hōʻemi ʻana ʻeha hōʻeha i ka hoʻomaha a me ka pinepine pō poʻomanaʻo nā puʻupuʻu haʻahaʻa (ʻoi aku ka nui o nā keiki bipi keiki).

Pentoxifyllinehōʻike ʻia e ka hepatic wikiwiki hoʻokūkū me ka hoʻokuʻu ʻana o nā huahana metabola ikaika. ʻO ka mea nui loa nā metabolites noonoo1-3-carboxypropyl-3,7-dimethylxanthinenona ka plasma mea e 8 manawa kiʻekiʻe aʻe ma mua o ka serum palekezila a 1-5-hydroxyhexyl-3,7-dimethylxanthine5 mau manawa kiʻekiʻe papa plasma palʻaihopezila.

Ua loli ka bioavailability o kēia lāʻau lapaʻau a ʻokoʻa ma waena o 6-32%. Hoʻohui ka ʻai ʻana i ka Cmax palʻaihopezila e ka 28%, a me kāna AUC e 13%, me Cmax 1-5-hydroxyhexyl-3,7-dimethylxanthine hoʻonui ʻia 20%.

Ke lawe ʻia ma nā maʻamau, nā papa maʻalahi maʻalahi o TCmax palekezilahe 60 mau minuke, i ka wā e lawe ai i nā papa keke - 120-240 mau minuke. Ma hope o kahi hapalua hola me ka palekezila ma ka pāʻana o 200 mg, kona Vd ma ka pae o 168 lita, a ʻo ke keʻena he 4500-5100 ml / min.

Ua nānā ʻia T1 / 2 ma hope o kahi kahiki o 100 mg palʻaihopezilaʻo 1.1 hola, ma hope o ka hoʻokō kūloko o nā papa - 0.4-0.8 hola. ʻO T1 / 2 o nā huahana momona koʻikoʻi ma waena o 1 a 1.6 mau hola.

Kuhi ʻia ka 94% e nā pōpoki a me 4% e nā mea kani, i loko o nā mea o nā metabolites. Ma kahi o 90% e hoʻohana ʻia ma ka 4 mau hola mua palʻaihopezila.

Me ka eha ʻōpala lolo kali i ka excretion o metabolites ka ʻike ʻia.

I nā puʻuwai naʻau aia ka hoʻonui i ka bioavailability a me kahi hoʻonui o T1 / 2.

Nā hōʻailona no ka hoʻohana ʻana

Hoʻohana ʻia ka hoʻohana ʻana o Agapurin no ka mālama ʻana o:

• maʻi huapuni holoʻokoʻaka hiki ʻana mai ma ke kua mumū, maʻi maʻi, kaʻina hana atherosclerotic (komo hoʻopili lohipili me obliterating endarteritis, ka mākaukau maʻi maʻi, atherosclerosis),
• huhui(komo acrocyanosis, aloha, ʻO ka maʻi o Raynaud),
• nā maʻi kiko trophicma muli o nā pathologies nania i ʻole haehae i ka aie (komo hauʻolima, gangrene a ʻōpio varicose),
• palewa holo koko koko o ka lolo ischemic etiology o ke kuula a me ke ʻano maʻamau (incl. atherosclerosis cerebral),
• nā lawehalakaʻalo koko ocular (komo pū ka lawa o ke koko i ka choroid a me ka retina)
• mau aupuni i nānā ma hope māhāelike ischemica hemorrhagic,
• nā maʻi vascular ʻano hana waena pepeiao me ka nānā ana lohe pio.

Nā Hoʻohui

ʻO ke koho ʻana iā Agapurin i loko o:

• ua haiia atherosclerosis(cerebral a i ʻole coronary),
• o ka hāpai ʻana,
• myocardial infarction (i kāna manawa koʻikoʻi)
• porphyria,
• hana waiū,
• waiwai nui nā nāʻeʻeha o ka naʻau,
• ʻōpū kik hemorrhagic (i kāna manawa koʻikoʻi)
• pilikino haaheoi palekezilaa / me nā mea ʻē aʻe o ka lāʻau lapaʻau,
• he kumu ʻole haehae maʻi,
• heminal hemorrhage,
• nunui kahe koko,
• i na makahiki he 18.

Pākuʻi ʻia nā contraindications:

• labile HANʻI,
• CHF,
• ʻāhā peptic,
• predisposition i haehae maʻi,
• propensity no ʻūhā,
• akeʻai / palu paleka,
• kūlana hana.

Nā hopena hopena

Nā hui ʻalani:

Pūnaehana pōkole:

ʻIli:

• hiperemia o ka maka,
• mau kui kuku
• Nā kuikahi(ma ka pili pinepine ma ka umauma a me ka maka).
• ka māla ʻana.

Pūnaehana Cardiovascular:

ʻ systemnaehana digestive:

• ʻōpū ma ka ʻōpū,
• he ʻeha o loko o ka ʻōpū
• hoala cholecystitis,
• ninini / luaʻi
• ka ʻaila koko ʻana,
• hoemi mea momona,
• hepatitis cholestatic.

Hematopoietic hui:

• pancytopenia,
• hypofibrinogenemia,
• thrombocytopenia
• ka hoʻomohala ʻana o ke koko mai nā ipu ʻili,
• leukopenia.

Hōʻike kūlike:

Nā ʻōkuhi noiʻi noiʻi:

• hoʻonui i nā pae transaminase ate.

ʻO Agapurin, nā ʻōlelo aʻoaʻo no ka hoʻohana

Ke kuhikuhi nei i ka hoʻohana ʻana iā Agapurin ma ka maʻamau maʻamau (i ka manawa hoʻokahi) ka kō ʻana o nā papa ʻelua a me nā papa retard. ʻOi aku ka maikaʻi ke lawe i ka pāpale koke ma hope o ka ʻai ʻana i kona ʻano holoʻokoʻa.

Ke koho ʻana i ka mālama ʻana me ka hoʻohana ʻana i nā papa maʻamau, ua hoʻokō ʻia ka wiki mua loa o ka maʻi ma kahi o 200 mg (2 papa) me kāna mau manawa ʻekolu i ka lā. I ka hōʻike ʻana o nā hōʻailona maikaʻi ʻole mai ka pūnaehana ʻōnaehana pokapū, gastrointestinal tract a i ʻole he ʻeha hoʻohaʻahaʻa i ke kokoe hoʻoneʻe ʻia ka papa helu aʻo ka mālama ʻana i ka pinepine o ka lawe ʻana i nā papa.

Me ka papa hana, e like me ke kānāwai, ua hoʻolilo ʻia kahi intake ʻekolu mau manawa o 100 mg (1 papa) o Agapurin i 24 mau hola, me ke ʻano he nui no kēlā me kēia lā o 1200 mg.

Ma ka hihia e nānā ai nā mālamalama maikaʻi ʻole me ka pae mea hana i oi aku o 400 mmol / l, uku hoʻemi ʻia ʻo dosage e ka 30-50% ua hoʻomaʻamaʻa ʻia.

Ke hoʻohana nei i nā ʻano lōʻihi o ka lāʻau, nā Agardin retard tablets, kahi papa lāʻau a me ka dosage e hoʻonohonoho pono ʻia e like me ke kiʻi o nā maʻi maʻi o ka maʻi maʻi a me ka hopena therapeutic i hana.

Pono ka hoʻohana ʻana o nā papa ʻaʻaka ʻo Agapurin 400 i nā lā 2-3, i ka lā, 600 CP - ʻelua mau lā i ka lā. ʻO ka dosage i nā lā a pau loa he 1200 mg.

I ʻōpala lolo me CC ma lalo o 30 ml / min, ka lōʻihi o 24 mau hola e hiki ke lawe i ka 2 papa o 400 mg.

Me ka eha nā puʻuwai naʻauhōʻemi ʻia ka hoʻokaʻawale ʻana o nā papa no ka lōʻihi o ka papa palʻaihopezila.

Ma nā hihia o ka koho ʻana o Agardin i ka mea maʻi me hypotensiona i ʻole i nā kānaka iʻa hoʻohaʻahaʻa i ke koko (Maʻi maʻi Ischemicvascular stenosisʻākoʻa, limau) Me ke ʻano o ka mālama ʻana me nā mea liʻiliʻi palʻaihopezila, me kā lākou māhuahua i hoʻonui i nā waiwai pono.

Hiki ke mālama ʻia i ka hoʻonā ʻana o ka hoʻonā ʻana o Agapurin intravenously, intravenously a i ʻole intramuscularly, me ke kino o ka mea maʻi.

Ke lawe nei i ka infusion intravenous i loko o kēlā me kēia lā no 100 mg (1 ampoule), hoʻoiho ʻia ma ka 250-500 ml o nā ʻina. sodium klorida (0.9%) a i hoʻolaha (5%) no nā hola 1,5-3. Me ka pane maikaʻi ʻana i ka infusion e holo mau ana, hiki paha i ka pāpālua i ka nui. Loaʻa i kēlā me kēia lā, hiki iā ʻoe ke komo i loko / i 300 mg.

Hoʻopuka mua ʻia ka hana Intraarterial i loko o kahi waihona ʻo 100 mg waiʻa i 2050 ml o ka hoʻonā sodium klorida (0.9%). I ka wā e hiki mai ana, 200-300 mg i ka 30-50 ml o kahi hopena kahi i kuhikuhi ʻia sodium klorida(0.9%). ʻO ka palena o ka hoʻokele o 100 mg o Agapurin ma kahi o 10 mau minuke. Ma ka hihia o ka aihue ua haiia vascular atherosclerosisloloʻaʻole i ʻae ʻia ka hoʻomaka ʻana o ka hoʻonā i loko o ka ʻatikala carotid.

I ʻōpala lolo me CC ma mua o 10 ml / min, ke hōʻemi ʻia nei ka nui o ke kupa Agjectin injectable e 30-50%.

Hoʻokomo ʻia ka injram Intramuscular o ka hopena i 1-2 mau manawa ma 24 mau hola ma kahi wai o 100 mg (1 ampoule).

Ke keu

Me kahi hala o Agapurin i nānā: hōʻike nā nāwaliwali, hoʻohaʻahaʻa i ke kokomanaʻo āhāhuʻehyperthermia tachycardia, mai nāwaliwalimāhuahua hiamoe, hue, nalowale o ka ike anahuhū hue nuitonic-clonic nahoamea hoʻonāʻau ka ʻaila koko ʻana (no ka laʻana, e hoʻohālikelike ana i nā "pā kī").

Pono ka mālama ʻia o ia ʻano e pili ana i nā hōʻailona i nānā ʻia, ʻoiai e mālama ana (inā pono) ke ʻano o ke koko maʻamau a me ka hana hanu.

Hoʻohui

Hoʻohana pinepine ʻia o Agapurin me kekahi xanthinese hoʻonui pahaake hopohopo.

ʻO nā hopena palekezilahiki paha i ka hoʻoikaika ka momona valproiclāʻau lapaʻau e pili ana i ka coagulability koko (thrombolytics, anticoagulants), a me antibiotika (komo cephalosporins).

Hoʻonui ʻo Agapurin i ka holomua insulin, antihypertensivehoʻālaa waha nā lāʻau maʻi hypoglycemic.

ʻO nā ʻano hana me ʻO Cimetidine hoʻonui paha i nā mea pili i ka plasma palekezila, ke hoʻonui nei i ka hiki o nā hopena ʻaoʻao.

Nā ʻōlelo kikoʻī

Pono e mālama ʻia ka lāʻau Agapurin ma lalo o ka hana mau ʻana kaohi koko. ^ E Ha yM. I nā maʻi me CHFpono ke hoʻokō uku koko holo koko.

I ka hoʻokipa ʻokoʻa anticoagulantse kia pono ake ʻaʻe koko.

ʻO ka hoʻohana ʻana i nā inika nui o Agapurin no ka mālama ʻana i nā mea maʻi me maʻi maʻiʻo ia hoʻi nā lāʻau maʻi hypoglycemichiki ke alakaʻi i ka hoʻokumu ʻana hypoglycemiapono ia e hoʻoponopono i ka regimen dosage.

I ka poʻe maʻi i hōʻili ʻia i kēia manawa hoʻōki kūlokoPono ka nānā ʻana o ka nānā ʻana hematocrit a hemoglobin.

Ke kali nei i kahi maʻi understateda i ʻole he kahe koko paʻa Pono e hoʻohana pono ʻia nā kaha kūpono loa o Agapurin.

No ka mālamaʻana i nā maʻi maʻi maʻi, pono ke hoʻoponopono ʻia i ka dosage, ma muli o ka emi ʻana o ke helu helu.

I hui kūloheloheHiki i nā maʻi ke hōʻemi i ka hoʻohaʻahaʻa ʻana i ka hopena o ka hopena o Agapurin.

ʻO ka kūpono o ka Agapurin injectable me nā hoʻonā infusion e pono ke nānā ʻokoʻa.

• Theonicol,
• Xanthinol Nicotinate.

• Kauhi,
• Kuahi pua,
• Pentiline,
• Trenpental,
• ʻĀina,
• Pentoxifylline.

Ma muli o ka palekana pono ʻole a me ka hopena o Agapurin i ka wā kamaliʻi, ʻaʻole ia i kuhikuhi no ka mālama ʻana o nā mea maʻi ma lalo o ka makahiki 18.

I ka helu ʻana (a me ka lactation)

Ma mua o 90% o nā hihia, he maikaʻi nā loiloi e pili ana iā Agapurin. ʻO nā poʻe maʻi e lawe nei i kēia lāʻau lapaʻau ka mea ʻoluʻolu ʻē loa a kūlike me ka maikaʻi me ka ʻike pinepine ʻole i ke kūkulu ʻana i kekahi ʻano hopena maikaʻi ʻole.

Hiki iā ʻoe ke loaʻa pinepine i nā loiloi a me nā loiloi no ka hoʻohana ʻana iā Agapurin i huu kino, no ke kumu o ke kumu ua kapaia wōloʻi(ka hoʻohui ʻana a me ka pālahalaha o ka nui o ka iwi ma hope o ka hoʻoikaika kino). I kēia hihia, hoʻonoho ʻia ka lāʻau lapaʻau i ke ala o ka wikiwiki loa hoʻoikaika kinoma muli o ka holomua microcirculationiloko o na wahī. He mea kūpono ia e hoʻomaopopo ma mua o ka lawe ʻana iā Agapurin i huu kinopono e kūkākūkā mua ʻoe me kāu kauka, no ka mea ʻo ke olakino olakino ʻē aʻe i pili pono i ke kūlana kūloko o nā ʻokoʻa a me nā ʻōnaehana o ke kino.

ʻO ka hui a me ke ʻano o ka lāʻau lapaʻau

He inoa honua anei ʻo Agapurin? ʻO Pentoxifylline kāna inoa lua.

I kēia manawa, loaʻa kēia lāʻau lapaʻau i nā ʻano like ʻole:

1. Nā papa Biconvex, hohola (keʻokeʻo) a loaʻa ka sheen glossy. ʻO kēia lāʻau lapaʻau ka waihona o ka pentoxifylline hāmeʻa a me nā mea hou aʻe (ka lactose monohydrate, kaʻai palaoa, kaomi anlodrous colloidal, talc a me ka magnesium stearate). Aʻo ka ʻā, ua loaʻa nā mea like e like me ka sodium carmellose, crystalline sucrose, powdered sucrose, talc, methyl paraben, titanium dioxide, anhydrous colloidal silicon a me ka acacia gum.
2. Hoʻolaha (ʻike, ʻaʻole i ʻulaʻoni ʻia), i manaʻo ʻia no ka maʻi maʻi. Loaʻa i kēia lāʻau lapaʻau ka pentoxifylline, sodium klorida a me ka wai no ka injection.

Makemake wau e ʻōlelo aku i loko o nā māka paʻa i ka mea hiki nō ke loaʻa ke ʻano he lāʻau lapaʻau like me ka Agapurin Retard. ʻO ka ʻōlelo a kēia lāʻau lapaʻau e ʻōlelo nei he hana lōʻihi. Loaʻa ia ma nā papa, kahi i pani ʻia me ka poni kiʻi ʻia. ʻO kēia lāʻau lapaʻau ka pentoxifylline a me nā mea hou e like me hypromellose, povidone, talc a me ka magnesium stearate.

ʻO nā waiwai Pharmacological

Heaha o Agapurin? ʻO ka ʻōlelo aʻo no ka hoʻohana ʻana i kēia ʻaina he antispasmodic a hui i ka hui o nā purines. Hoʻonui nui ia i ka microcirculation koko, me kāna mau waiwai. ʻO ka pahuhopu o ka hana o kēia lāʻau lapaʻau ka pale ʻana i ka phosphodiesterase a hoʻonui i ka ʻike o ka ATP i nā selela koko a me ka CAMP i nā platelets me kahi saturation o hoʻokahi manawa o ka ikehu. Ma muli o kēia, hopena ka vasodilation a me ka hoʻohaʻahaʻa ʻana i ka pale kūʻokoʻa vascular (peripheral) i loaʻa, a me ka piʻi ʻana o ka minuke a me ke kahe o ke koko me ka loaʻa ʻole o ka loli nui o ka puʻuwai.

Ke ʻano o ka hana o ka lāʻau

He aha ka hana o ka hana a ka lāʻau lapaʻau "Agapurin"? ʻO nā ʻōlelo e hoʻohana ai e hāʻawi i kahi pane pau loa i ka nīnau. Ma hope o ka hoʻopili ʻana i ka lāʻau lapaʻau, hoʻonui ka nui o nā coronary, a laila hoʻomohala i ka hāʻawi ʻana o ka oxygen i nā moku o ka pūpū a me ka hoʻonui ʻana o myocardium, ʻike ka hopena antianginal a hoʻomaikaʻi ka oxygenation koko.

Pono e hoʻomaopopo ʻia he hiki i ka lāʻau lapaʻau i hiki ke hoʻonui i ka leo o nā ʻōpū o ka hanu, inā paha, ʻo ka diaphragm a me nā mea hoʻoleʻaleʻa kūloko.

Me nā intravenous injections, e alakaʻi ai i ka hoʻonui i ke kaila koloa, a me ka hoʻonui ʻia ʻana o ka nui o ke koko e kahe ana ma waena o 1 pauku. Eia kekahi, ʻo kēia lāʻau lapaʻau e alakaʻi ai i ka hoʻonui ʻana i nā kiko o ka adenosine triphosphate i loko o ka lolo a he hopena maikaʻi ma ka hana bioelectric o ka wahī.

Wahi a nā ʻōlelo kuhikuhi, hiki i ka lāʻau lapaʻau i ʻōlelo ʻia i hiki ke hoʻemi i ka nānā ʻana i ke koko, e hoʻonui i ka elasticity o nā membrane erythrocyte a hoʻomaikaʻi i ka microcirculation me ke kahe koko.

He aha nā hiʻohiʻona i ka lāʻau lapaʻau "Agapurin"? ʻ saylelo nā ʻōkuhi no ka hoʻohana ʻana i ka hana mau manawa o nā arteri (peripheral), hiki i kēia lāʻau lapaʻau ke alakaʻi i ka hoʻohemo ʻana o nā pōpoki pō i nā ʻeha o ke keiki bipi, e hoʻonui ana i ka lōʻihi o ka hele wāwae a me ke kaumaha i ka hoʻomaha.

Lapaʻau lāʻau

ʻO ka lāʻau lapaʻau "Agapurin" wikiwiki hou i loko o ke akea. I kēia hihia, ua hoʻokumu ʻia nā metabolites ikaika.ʻO ko lākou nānāʻana i ke koko he mau manawa kiʻekiʻe ma mua o ke kaū ʻana o ka mea nui.

Hōʻike ʻia ka lāʻau lapaʻau i ke ʻano o nā metabolites ma kahi nui o 94%, a me ke koena ma loko o nā ʻāpana. I ka hana he 4 mau hola ma hope o ka hoʻokele ʻana, haʻalele ka lāʻau i ka nui o 90% o ka nui i hoʻohana ʻia. Ke loli ʻole, ua paʻi ʻia i loko o kahi waihona o 2%. Pono e hoʻolilo i ka mea ikaika o ka pentoxifylline a me nā metabolite i hoʻopaʻa ʻole i nā palekō koko.

Me nā hana renal impaired, hoʻemi ka hua o ka metabolite. Me ka hana pono ole o ka ate, ua nānā ʻia kahi elongation o ka hapalua hapalua, me ka nui hoʻi o ka bioavailability.

ʻO ka lāʻau "Agapurin" (mau papa): nā ʻōlelo no ka hoʻohana ʻana

E like me nā ʻōlelo i hoʻopili ʻia i ka lāʻau lapaʻau, pono e lawe ʻia i ka manawa like o ka lā ma hope o ka ʻai ʻana i ka meaʻai, holoi ʻia me ka wai maʻamau. ʻAʻole pono e ʻoka ʻia ka lāʻau lapaʻau.

ʻO ka inikua mua o ka lāʻau lāʻau 200 mg ʻekolu mau manawa i ka lā. Inā lōʻihi ka maʻi o ka mea maʻi a i ʻole nō hoʻi ʻo ia ke hoʻomanawanui i ka lāʻau, a laila hiki ke hoʻemi ʻia kahi laikini hoʻokahi e ka hapalua like, akā i ka manawa like, pono e mālama ʻia nā helu o ka nui.

ʻAʻole pono nā dosage o kēlā me kēia lā pono i ka 1200 mg.

I kēia manawa ʻike ʻoe pehea e hoʻohana ai i ka lāʻau lapaʻau "Agapurin" (nā papa). ʻO nā ʻōkuhi no ka hoʻohana ʻana i kahi lāʻau like like me ka hana lōʻihi e loaʻa ana i ka ʻike e pili ana i ia mau papa like. Eia naʻe, inā hoʻohana ia, hiki i ka hōʻemi i ka lālama hoʻokipa hiki nō.

Nā ʻōkuhi no ka hoʻohana ʻana i ka maʻi maʻi

Pehea e hoʻohana ai i ka lāʻau lapaʻau "Agapurin"? Hoʻololi pinepine ʻia nā papa e nā kauka i nā hopena injectable. Inā, no kekahi kumu, ʻaʻole hiki i ka mea maʻi ke lawe i ka lāʻau lapaʻau ma mua, a laila e kau ʻia ai nā inikini.

ʻO kēia lāʻau lapaʻau, hana ʻia ma ke ʻano o ka hoʻonā no ka maʻi pehu, hiki ke lawelawe ʻia i kekahi o kēia ʻano hana:

1. Intra Pono e hoʻoneʻe ʻia nā kiko o ka ampoule i 5% hopena o ka glucose a i ʻole hoʻi i loko o 250-500 ml o ka waiū o ka sodium chloride (0.9%). Pono e hoʻolōʻihi ʻia ka lāʻau lapaʻau, ʻaʻole ʻoi aku ma mua o 150 ml i hoʻokahi hola. Inā hoʻomanawanui maikaʻi ka mea maʻi i ka lāʻau lapaʻau, a laila e hoʻonui ʻia ka nui o kēlā me kēia lā i ʻelua mau ampoules, i.e. 200 mg.
2. Hoʻopili Hoʻohanaʻia ka lāʻau ma 100 mg ʻelua i kēlā me kēia lā. I kēia hihia, pono e hoʻokahe ʻia nā ʻike o nā ampoule.
3. Ke oki nei. Pono e hoʻomaka i ka mālama ʻana i ka mea maʻi me ka hoʻopuka ʻana i hoʻokahi ampoule, pono e hoʻoheheʻe ʻia i mua o 20-50 ml o ka sodium chloride isotonic. Inā makemake ʻia ka lōʻihi o ke ʻano, hiki ke hoʻonui ʻia i ka dosage i 2-3 ampoules. Pono lākou e hoʻōla me ka 30-50 ml o ka hoʻonā.

Pono e hoʻomaopopo ʻia ua hoʻoholo ʻia e ke kauka wale nō ka hopena o ka nui o ka lāʻau lapaʻau a hiki i ka manawa kūkākūkā maʻi hoʻokahi.

Ka lāʻau lapaʻau "Agapurin": hōʻailona no ka hoʻohana

Ma mua o ka hoʻohana ʻana i kēia lāʻau lapaʻau, pono ʻoe e ʻimi i ke kauka a i loaʻa iā ʻoe kahi hoʻokolohua. Ma hope o nā mea a pau, hoʻokaʻawale ʻia kahi lāʻau lapaʻau no kekahi mau mea ʻē aʻe. E noʻonoʻo hou i kā lākou papa inoa.

1. ʻO nā maʻi kikoʻī trophic i kū mai i kahi kūlana o ka poʻokela maikaʻi ʻole a me ka microcirculation arterial (no ka laʻana, gangrene, varicose ulcers, frostbite, etc.).
2. ʻO ka hoʻopauʻana o ke kahe koko (peripheral), i hana ʻia ma muli o ke ʻano o ka hōʻeha ʻana, nā atherosclerotic a me nā ʻōnaehana maʻi. Pēlā nō, ʻo ka lāʻau ke kauoha i ke ʻano no ka "intermittent", kahi i loaʻa ai e ka atherosclerosis, obliterating endarteritis a me ka angiopathy maʻi maʻi.
3. ʻO ka maʻi a me ke koʻikoʻi cerebrovascular ulia, kahi o ischemic kumu. Eia kekahi, ua hoʻohana ʻia ka lāʻau lapaʻau no ka atherosclerosis cerebral, paresthesia, angioneuropathy, maʻi a Raynaud a me ka acrocyanosis.
4. ʻO nā maʻi hele i loko o nā moku o nā kino ʻike (ma ka hana a me ka paʻa ʻole o ka hele a i ʻole ka hopena o ka vascular a me ka retina o ka maka).
5. ʻO nā kūlana e ulu ana ma hope o kahi stroke ischemic a hemorrhagic.
6. ʻO nā ʻeha o ka pepeiao waena o ka puka vascular, ka mea i hui pū ʻia e ka nalowale hoʻolohe.

Ka makaʻala ʻana me ka lāʻau lapaʻau

Me ka nui o ka makaʻala, pono e hoʻohana ʻia kēia lāʻau lapaʻau i ka poʻe maʻi me ka makemake o ka hypotension, me ka nui o ke koko lae, hōʻemi ka naʻau (maʻi), makemake i ka hemorrhage, renal a me ka maʻi hepatic, a me ka mokuʻāina ma hope o ka ʻoihana.

Nā hopena hopena

Aia paha nā hopena pilikino o ka lāʻau "Agapurin"? Nā papa hana, ka ʻōlelo a ka mea i hōʻike ʻia ma luna nei, a me kahi mea no ka inikua hiki ke loaʻa i kahi nui o ka hopena maikaʻi ʻole. E noʻonoʻo pono iā lākou i nā kikoʻī.

• Pūnaehana Digestive: hepatitis cholestatic, intestinal atony, exacerbation o cholecystitis, waha maloʻo a hoʻemi i ka makemake.
• Pūnaʻi wahī: hopohopo, hoʻomehana neʻe, hoʻomāʻeha, nā puʻupuʻu a me nā poʻo.
• ʻO nā kīʻaha koko a me nā ʻili: ka huehue, nā kuku palu, ka holo ʻana o ka ʻili, ka holo ʻana o ke koko i ka umauma o luna a me ka maka.
• Pūnaehana Cardiovascular: arrhythmia, cardialgia, ka holomua o ka angina pectoris, tachycardia a me ka hoʻohaʻahaʻa i ke koko.
• Hematopoietic o nā ʻāpana a me nā ʻōnaehana hemostatic: thrombocytopenia, leukopenia, pancytopenia, hypofibrinogenemia, pehu mai ka ʻōpū, ʻōpū, nā kapili a me ka ʻāwīpīpī.
• Nā kino keu: ʻike maka a me nā scotoma.
• He maʻi kūlohelohe: itching, urticaria, angioedema a me kahi anaphylactic shock.

Nā hihia keu

He aha ka mea e hoʻohana ai inā hoʻohana wau iā Agapurin (400 mg, 600 mg, 1200 mg) i nā inika nui? Ma kēia hihia, ʻike paha ka mea maʻi i nā hōʻailona pathological e like me ka nāwaliwali, kahi mākaʻikaʻi i hōʻailona ʻia i ke koko, ka ʻōpū, ka tachycardia, nā nāwaliwali, ka hiamoe, nā manaʻo hoʻonaninani tonic-clonic, ka nalowale o ka naʻau, hyperthermia, hoʻonui i ka huhū a me ka huhū, nā hōʻailona o ke koko gastrointestinal (ma ke ʻano, e hoʻohālikelike ana. kīwī kekeʻe) ") a pihi.

I kēia hihia, pono ka hoʻāʻo ʻia o ka hōʻailona hōʻailona maʻi, ka mea e kuhikuhi ana i ka mālama ʻana i ke koko maʻamau a me ka hana ʻana i ka hanu.

Nā ʻano hana o ka mālama mālama i ka lāʻau, nā loiloi e pili ana i ia, kumukūʻai

ʻO ka lāʻau lapaʻau "Agapurin" ua kūʻai ʻia ma nā wahi āpau āpau. Oe ke kuai he 60 papa (100 mg) awelika no ka 250 mau rubles Russian.

ʻOi aku ka maikaʻi o nā loiloi o nā mea maʻi e pili ana i kēia lāʻau lapaʻau. ʻO ia ke kumu i hōʻike pinepine ʻia ai ma mua o nā lāʻau lapaʻau i nā mea maʻi i loaʻa nā pilikia me nā kīʻaha koko.

Pono e hoʻomaopopo ʻia he mea kaulana loa ka lāʻau "Agapurin" i ka bodybuilding. ʻ saylelo nā loiloi o nā mea hana kino ke pono ke noʻonoʻo pono ʻia kēia mea hana mai nā lāʻau ʻē aʻe e kōkua ai e hoʻomaikaʻi i ke kahe koko. Ma hope o nā mea a pau, ʻo ia ka mea e ʻoi loa a ma ka manawa like me ka pau ʻole.

He kūpono kēia lāʻau lapaʻau i nā mea hoʻokani e hele, no ka mea, ʻaʻole i loaʻa wale i ka hopena o ka hoʻonā no ka hoʻonāukiuki, akā i nā palapala papa. I loko o nā pakaʻai, hiki ke loaʻa kēia mea ma lalo o nā inoa ʻē aʻe e kani like me "Pentoxifylline" a i ʻole "Trental."

ʻO ka pahuhopu nui o ka lāʻau hāʻawi i hoʻonui ʻia e hoʻonui ai i ke kani o nā kīʻaha koko, e hōʻemi i ka nānā koko a hoʻonui i ke kahe koko. He ala maikaʻi kēia a pau no ka hoʻokō ʻana i ka pīkoi ma ke aʻo ʻana i ka haʻuki, i ka wā e ʻike ai ka pulu ikaika ʻana o ka māka ʻana o nā mea hana.

E hoʻohana pono i kēia lāʻau lapaʻau i nā bodybuilders akamai e makaʻala loa, no ka mea, hiki iā ia ke hoʻolilo i kahi overdose a me nā helu o nā hopena ʻaoʻao.

E kūʻai ʻo "Agapurin" i kahi ʻeleʻele a maloʻo hoʻi, kahi i loaʻa ʻole ai nā keiki liʻiliʻi. I kēia hihia, ʻo ka mālama ʻana o ka lāʻau o kēia lāʻau he 10-15 tikeline wale nō. Hōʻike ʻia ka manawa paʻa ma ka pale a ua like ia me nā makahiki ʻelua. Ma hope o kēia manawa, pāpā ʻia ka hoʻohana ʻana i nā lāʻau lapaʻau.

I ka hopena, ʻike hou mākou ʻaʻole pono ʻoe e kuhikuhi kūʻokoʻa iā ʻoe iho i kēia lāʻau. Pono ka hoʻoholo ʻana o ka lōʻihi o ka mālama ʻana a me ka ʻimi ʻana e ke kauka no kahi maʻi maʻi.

Pehea e lawe ai i ka agapurin i ka hoʻoikaika kino

I loko o nā manawa hoʻoikaika o ka hoʻomaʻamaʻa ʻana, ua ʻōlelo ʻia e lawe i ka lāʻau lapaʻau e like me kēia: 3 mau manawa i ka lā, 2 papa ma hope o ka pāʻina. Ma nā lā aʻo kau ʻole, 1 papa 3 mau manawa i ka lā a ma hope hoʻi o ka papaʻaina. Lawe ʻia ʻo Agapurin no 3 mau pule, ma hope o kāu e pono ai ke hoʻomaha i kahi mahina. I kēia manawa, hoʻomau ʻoe e hoʻomaʻamaʻa e hoʻomaka e lawe i ka agapurin i ke pae hou, me nā kaupaona hou. ʻO ka hoʻohana ʻana o kēia mau papa e pili ana i ka hoʻohana ʻana i kahi nui o ka wai no ka inu. I ka hihia ke kāhea ʻia kēia lāʻau lapaʻau i loko o ke kino me ka mea pohihihi, a laila koho wale ʻia ka nui a me ke wā o ke kiʻi ʻana. ʻO ka hoʻokipa ʻana i kēia ʻano kumu no ka pākiki ʻoi aku ka maikaʻi me ke kauka e pale iā ʻoe iho i nā hopena ʻaoʻao hope.

ʻO Agapurin i loko o nā lāʻau lapaʻau e kūʻai ʻia ma lalo o nā inoa e like me ka trental a me ka pentoxifylline. Loaʻa lākou i ka pā o nā papa a ʻokoʻa ʻole i nā kumukūʻai kumukūʻai. ʻO 24 mau malama o ke ola o ka lāʻau lapaʻau, a ʻo ke kumu kūʻai he 260 mau rubles no 60 papa o 100 mg. Aia pū kekahi i nā paʻi me nā papa o 400 a me 600 mg.

Nā kūlike a me nā contraindications

ʻO Pentoxifylline ka mea ikaika o kēia lāʻau lapaʻau a hōʻailona pū ʻia e nā kahe like me ka paʻa o ke ʻano i loko o ke kino. Ma hope o kekahi mau hola, hiki iā ʻoe ke hoʻomaopopo i ka nui o ke kaila o ka mea ikaika ma hope o ka hoʻokele ʻana. Hoʻopili ʻia ka waiwai mai ke kino me ke kōkua o nā keiki a me nā ʻōpū.

Hoʻohana ʻia ʻo Agapurin i ka lāʻau lapaʻau ma ka mālama ʻana i nā maʻi like me ka varicose veins, frostbite, circulatory disorder, etc. A ʻo ke bodybuilding hoʻohana ʻia he mea maʻamau loa, no ka mea, ua nele nā ​​ʻike pono, akā naʻe ke hoʻoholo nei nā mea hoʻokūkū e lawe i kēia lāʻau lapaʻau. Ma ka manawa like, loaʻa i ka lāʻau i nā contraindications, ʻoi aku no kēlā mau kāla o nā kamaʻāina i ola i ka myocardial infarction, mai ka maʻi cerorrral hemorrhages a i ʻole ka hoʻokahe koko. ʻO ka lawe ʻana i kēia lāʻau lapaʻau hiki ke alakaʻi i ke ʻano o ke kuni, ka ʻeha, nā hives, ka maʻi diakona, akā inā hele pololei ʻoe i nā ʻōkuhi, a laila hiki ʻole nā ​​hopena like ʻole i ka hopena.

ʻO nā loiloi o nā mea hōʻeuʻeu ma hope o ka lawe ʻana i kēia lāʻau, ma ke ʻano he kānāwai, he maikaʻi. ʻO nā hopena ʻaoʻao, ʻoiai i hoʻokaʻawale ʻia, ʻokoʻa loa. Ma muli o ka hana pinepine ʻia e nā mea hoʻokūkū loea, nui maoli lākou i nā mea e ʻimi ponoʻi ana i nā ʻōkuhi. Inā i kū ʻia nā hopena maikaʻi, ʻo ia wale nō ka hewa o nā mea pāʻani. Inā ʻoe e hoʻohana pololei a me ka naʻauao, ʻo ʻoe wale nō ke pōmaikaʻi: ʻoiai mua, hana ka lāʻau lapaʻau, a me ka lua, he ʻoi aku ia ma mua o nā analogues e loea ʻia e nā ʻoihana kaulana e hoʻomaʻamaʻa aku i nā lako hoʻohui.

Ka hana lāʻau lapaʻau

No ka piha o Agapurin i ka hui o nā purines a he hopena antispasmodic mauʻano (i.e. hoʻomaha i nā ʻalika maʻa). Ma muli o kēia, hoʻomaikaʻi ʻo ia i ke kahe o ke kahe a hiki i nā moku o ka liʻiliʻi liʻiliʻi a kōkua i ka hoʻomaikaʻi ʻana i nā ʻano o ka rheological o ke koko. ʻO ka vasodilation e alakaʻi ai iā Pentoxifylline e alakaʻi i kahi kaho o ka huakaʻi kūleʻa peripheral vipea, he hoʻonui i ka hōʻeha a me ka nui o ka puʻuwai. Eia naʻe, ʻaʻohe mea i hoʻonui i ka puʻuwai naʻau.

Hoʻopili ka mīkini hana pale thrombosis me ka hoʻokaʻawale ʻana o ka phosphodiesterase, ka piʻi ʻana o ka neʻe o ka cAMP i loko o nā platelets, a me ka hōʻiliʻili ʻana o ka ATP i loko o nā ʻāpana koko ʻulaʻula.

ʻAʻole ka mea nui loa ka mana o ka mana o Agapurin i nā lāʻau coronary. Hōʻike ʻo Pentoxifylline i kahi hopena antianginal i hōʻemi ʻia ma muli o ka hoʻonui ʻana ʻaʻole wale nā ​​kīʻaha koko o ka puʻuwai, akā pū kekahi o nā ʻōpū.

Hiki i ka lāʻau lapaʻau ke hiki ke hoʻonui i ka leo o ka diaphragm a me nā musc intercostal (nā mākau manawa o ka hanu).

Ma kahi o nā maʻi maʻamau o ka lalo o nā haʻahaʻa loa (e hoʻopau ana i ka endarteritis a i ʻole atherosclerosis), ka lāʻau lapaʻau, no ka hana antispasmodic a me ka antiplatelet hana, hoʻomaikaʻi maikaʻi i ka pōkole pō, hoʻonui i ka hele wāwae, a hoʻohemo i ka hōʻeha ma nā ʻeha o nā keiki bipi i ka hoʻomaha.

ʻLoe a me ke kākele

Lawe ʻia nā papa ʻaina Agapurin ma hope o ka ʻai, i ka manawa like o ka lā, me ka wai nui. ʻAʻole hiki iā ʻoe ke kiki i ka lāʻau.

ʻO ka hoʻomakaʻana o ka Pentoxifylline he 200 mg 3 mau manawa i kahi lā no 7 lā. Ma ka hihia o kahi emi o ke kahe o ke koko, a me nā hōʻailona no ke aʻalolo mai ke kaomi hana ʻana a i ʻole nā ​​ʻōnaehana nūna, e hoʻemi ʻia ka nui o ka maʻi ma ka 100 mg (like me 1 papa) me 3 mau lā i ka lā.

No ka mālama mālamaʻana, e hoʻohana ʻia he dosis o 100 mg i kakahiaka, i ke ahiahi a i ke ahiahi. I kēia hihia, lawe pinepine ʻia ka lāʻau i nā malama he mau mahina.

ʻO ka ʻokoʻa loa ka ʻimi i kēlā me kēia lā he 1200 mg.

Ma kahi pae o ka mea hana ma mua o 400 mmol / l (i ʻole a hoʻonā a i ʻole kaulike a nānā ʻole), hoʻemi ʻia ka nui ma ka hopena o 30% a 50%.

Nā hōʻailona āpau

Inā hoʻomaʻamaʻa pinepine ʻoe i nā lā a pau o ka lāʻau, nā hōʻailona e like me

• Ka nui o ka ʻike.
• Keʻulaʻula i ka ʻili.
• Pau ka ʻaihue ʻana mai nā moku o ka membrane kūwī o ka ʻāpana kūwā (a hoʻomoʻi ʻia, like me "kīwī kue").
• Kāleka, hui pū ʻia e ke kuni.
• Kauhane.
• ʻO ka hoʻouka ʻana o ka waiwai tonic-clonic.
• ʻEhaʻeha.
• Tachycardia.
• ʻʻAla

ʻAʻole loaʻa ka lāʻau lapaʻau i kekahi antidote kikoʻī, no laila, me ka hoʻomoʻukiʻi Agapurin, ua lawe ʻia ke ʻano maʻi lapaʻau nāna e mālama i ka hana nui o ke kino.

Hoʻohui nūhou

Hiki i ka Pentoxifylline ke hoʻomoʻa i ka hopena o nā lāʻau lapaʻau e hoʻopili ai i ke kaʻina ʻai coagulation. I waena o lākou: nā aʻa ʻole a me nā kuhikuhi anticoagulants, a me ka thrombolytics. Hiki ke hoʻomaopopo i ka hōʻalo ʻana i nā hopena ʻaoʻao me ka hoʻohana pū ʻana o Agapurin me nā ʻenehana antibacterial o ka pūʻulu cephalosporin (1-2 mau hanauna). ʻAʻole hiki ke loaʻa ka Pentoxifylline i ka hui pū me ka valproates (derivatives o ka valproic acid).

Ma muli o kāna mau hopena pharmacodynamic, hoʻonui ʻo Agapurin i ka maikaʻi o nā lāʻau lapaʻau e like me ka lāʻau antihypertensive, ka lāʻau hypoglycemic oral, a me ka insulin.

Hiki i ka histamine receptor blocker Cimetidine ke hoʻonui i ka kao o ka pentoxifylline i loko o ka serum koko. Hiki i kēia ke alakaʻi i kekahi helu o nā hopena ʻaoʻao a i ʻole paha i ka hōʻailona o ka overdose.

ʻAʻole pū pū kekahi ʻo Agapurin me xanthines, no ka mea hiki i kēlā mau lāʻau lapaʻau hiki ke alakaʻi i ke ʻano o nā hōʻailona o nā nīnū pili i ka mea maʻi.

Nā hopena hopena

• Pūnaehana huhū: nā mea hoʻohālikelike, hoʻokūkū, hopohopo, hopohopo, hōʻeha.
• Nā kūwaha kūpono (nā kiko momona subcutaneous a me ka ʻili): ʻulaʻula (hyperemia) o ka maka, ke ʻano ʻana o ka ʻalā ʻana i ke kino o luna, ka ʻū ʻana, hoʻonui i ka hiʻona o nā kui.
• Palapala Alimentary: exacerbation o nā hōʻailona o ka cholecystitis, hepatitis cholestatic, waha maloʻo, atony intestinal, hōʻemi ʻōpū.
• Uku pilikino: ke hiʻohiʻona o nā wahi ākea a i loko paha i mua o nā maka, kahi i hoʻemi i ka acuity ʻike.
• Hematopoietic kino a me ka ʻōnaehana hemostasis: hoʻemi i ka pae o nā platelets, leukocytes, fibrinogen, kahe koko mai nā kīʻaha o ka membrane o ka huina o nā mea kūwaho.
• Allergic mauʻike o nā ʻano pili koke ʻole a lohi.
• ʻO nā hemahema o nā labocities i nā loiloi biochemical: hoʻonui ALT, LDH, AST, phosphatase alkaline.

Nā kikowaena o Agapurin

Trental 400 Pentoxifylline Rivo, Fleksital, Pentoxifylline-ICN, Pentoxifylline, Pentoxifylline-Teva, Pentoxifylline'Acere, Pentoxifylline, Escom, Pentoxifylline-PVD Radomin, Agapurin retard Pentomer, Ralofekt 300 Ralofekt, Trental, H Trenpental, Pentogeksal, Pentilin forte, Pentamone, Pentoxifylline, Arbiflex-100, Pentilin, Agapurin 600 retard, Arbiflex-400 Vazonit, Agapurin SR

ʻAtikala lāʻau lapaʻau

ʻO Agapurin kahi lāʻau lapaʻau e pili ana i ka pentoxifylline.Aia ka lāʻau lapaʻau i nā metabolites mai ka pūʻulu o xanthines, nā hoʻomaʻemaʻe a ke kuhikuhi nei i ka hoʻoponopono ʻana a me ka hoʻomaikaʻi ʻana i ka microcirculation ma nā ʻano like ʻole o ka vascular. Ma muli o kahi vasodilator ikaika, hoʻomaikaʻi nui ʻo Agapurin i ka waiwai o ka rheological o ke koko, e hoʻolalelale i nā aronika coronary, kani ke kani ʻana, a hiki ke hoʻonui i ke kiʻekiʻe o ka ATP i loko o nā pūna o ke kino.

,

E hoʻokuʻu i ke ʻano

Loaʻa ka lāʻau lāʻau i loko o ka papa papa a me ka injection, ma nā ʻano like ʻole, kahi i hōʻike ʻia no nā ʻano ʻano vascular ʻē aʻe, e pili ana i ka nui o ka maʻi. Ma ke ʻano he kānāwai, inā e ʻike ʻia ka maʻi ʻino, ke hoʻokaʻawale ʻia nā kuhi ʻana iā Agapurin i ka maʻi intravenously a i ʻole intramuscularly, mālama mālama ʻia a mālama ʻia paha o nā maʻi maʻi e pili ana i ka lawe ʻana i ka lāʻau i loko o kahi papa.

• Nā hoʻonā o nā maʻi maʻi - ampoule o 5 mililiter, ma kahi pānaʻi o 5 ampoules
• 100 mau papale milligram, 60 papa no kahi vial
• Nā Pihi - 400 milligrams o ka pākaukau ikaika - 10 mau papa i loko o kahi palaha, 2-10 blisters ma ka hoʻopulapula maoli.
• Nā Papa - 600 milligrams o pentoxifylline, 10 mau papa no ka paluhalelo, 2 a 10 blisters no ia pā
• ʻO Agardin retard - 400, 600 miligram o ka mea hana ikaika, i loko o kahi pahu paila o nā papa he 10, i loko o kahi pānaʻi o 2 blisters

Aia i loko o ka mea pono nā 'āpana:

• Pentoxifylline (100, 400, 600 mg)
• : Lactose monohidate (lactose monohala, ka waiū waiū)
• ʻO ka pauma Talcum
• ʻ stlelo ʻehala
• Hōʻawewe Magnesium (kahi kōleʻa ʻo ka magnesium, stearic acid)
• Eloʻoliʻoni silicium colloidal (silic dioxide colloidal)
• Kaawe sodium, glycerol (cariumellium sodium)
• Kūpono
• Methylparaben (nui kikoʻī o ka methylparaben)
• Gummi arabicum (acacia gum)
• Titanium Dioxide
• ʻO ka cellulose Microcrystalline

ʻO ka helu a me ka hoʻokele ʻana o Agapurin

Lawe ʻia nā papa ʻaina Agapurin ma hope o ka ʻai ʻana, ʻoi aku ka maikaʻi ma ka manawa like. ʻO ka dosage mua, ma ke ʻano he kānāwai, ʻo 200 mg ʻekolu mau manawa i ka lā. ʻO ka poʻe maʻi i loaʻa ke hoʻolōʻihi lōʻihi, ʻo ia hoʻi ka poʻe i loaʻa i ka hypertension arterial a i ʻole nā ​​hōʻailona o ka gastrointestinal tract a i ʻole nā ​​hanana hoʻonāukiuki waena, hōʻemi ʻia ka dosage i 100 mg ʻekolu mau manawa i ka lā. ʻO ka dosage i nā lā a pau loa he 1200 mg.

Kuhi ʻia nā papa hana lōʻihi lōʻihi i ka 1 pc. ʻelua a ʻekolu paha i ka lā a.

Hiki ke lawelawe ʻia i ka hoʻonā Agapurin ma intramuscularly, intravenously a intraarterially. Hana ʻia ke kaʻina hana i ke kūlana kiʻekiʻe o ka mea maʻi.

Intravenously, ʻo ka lāʻau lapaʻau e mālama pinepine ʻia ma kahi o 100 mg (e pili ana i ka 1 ampoule), hoʻohemo ai i ka 250-500 ml o kahi hopena o 5% dextrose a i ʻole 0.9% pānaʻi sodium chloride ma loko o kahi pahu o 1.5-3 hola. Inā hoʻomanawanui maikaʻi ʻo Agapurin, hiki ke pāpālua ka nui, me ka nui o 300 mg.

I ka lā mua, ʻo 100 mg o Agapurin e mālama i intraarterially, hoʻohemo iā lākou i 20-50 ml o ka wai o ka sodium chloride, a laila 200-300 mg kēlā me kēia me ka hoʻōla waiwai me 30-50 ml. ʻO ka lōʻihi loa o ke kani ʻana he 10 mau minuke. ʻO nā mea maʻi me ka atherosclerosis koʻikoʻi o nā moku cerebral i pāpā ʻia mai ka hoʻoluhi ʻana i ka hopena i loko o ka arote carotid.

Hoʻonohonohoʻiaʻo Intramuscularly, ʻĀpana 100 mg hoʻokahi a ʻelua paha i ka lā.

Pono ka hoʻoponopono ʻana o ka Dosis i kahi kuhikuhi liʻiliʻi (ma kahi o 30-50%) e pono ai i ka poʻe me ka nele o ka hana renal (me CC ma mua o 400 mmol / l).

Nā kuleana a me nā kūlana e waiho ai

Manaʻo ʻia e mālama iā Agapurin i kahi maloʻo, pale ʻia mai ka lā maka a me ka wahi maikaʻi i ka mahana: 15-25 ºС - ma ke ʻano o nā papa, 10-25 º - ma ke ʻano o kahi hopena.

ʻO 5 mau makahiki ka palena o ke ola o nā papa Agapurin, ʻo 3 ka hopena.

Loaʻa kahi hewa i loko o ka kikokikona? Koho ia a kaomi Ctrl + Enter.

Ke hoʻohana nei iā Agapurin i ka wā hāpai

Wahi a nā ʻōlelo kuhikuhi, ʻaʻole i aʻo ʻia ka hoʻohana ʻana i ka wā o ka hapai. Eia nō naʻe, ma ka hana hoʻokalakupua lāʻau lapaʻau, ʻaʻole maʻamau nā hihia a hiki ke kuhikuhi ʻia kahi makuahine e hiki mai ana i ka lāʻau lapaʻau e loaʻa ai ka pentoxifylline. I ka wā hoʻi o ka hakahaka, hiki ke loaʻa nā ʻano maʻi ʻē aʻe o ka maʻi, a he mea koʻikoʻi kēia mau kūlana no ka hoʻomohala ʻana o ka pūpū. I kēlā mau hanana, e hāpai ana ke kauka i ka nīnau i ka hopena o ka hopena o ka hopena i ka makuahine a me ka hoʻoweliweli i ka pēpē. ʻO kekahi o nā kūlana e weliweli loa he gestosis, e ulu ana i ka lua o ka trimester ma muli o ka stagnation venous a clogging o nā capillaries. Hoʻomaka ke kaʻina e ke kuʻi ʻana, a laila hele ke keiki diffunction, ʻike ʻia ka protein i ka urine, ʻeha a me nā ʻōpio. Hoʻopilikia ka FPN - ka nele o ka fetoplacental, i hui pū ʻia e nā mākuʻi o ka vascular system o ka plasenta a me ka hypoxia fetal.
ʻAʻole hiki ke ʻae ʻia ka wā hoʻohana i ka wā hāpai i nā hihia like ʻole, akā, pono nō, no ka mea hiki i ka lāʻau lapaʻau ke hoʻihoʻi i ka microcirculation maʻamau a me ka kaila o ke koko i ka laulā. Ke kau nei i ka lāʻau lapaʻau e kōkua i ke hiki ʻana i ke kahe o ke koko, hōʻemi i ka nui o ka platelet aggregation (gluing), a e hoʻomaikaʻi i ka waiwai o ka rheological o ke koko. Hāʻawi ka Vasodilation i ke kaʻai pono o ke koko i nā ʻili a hōʻaʻole ʻia i ka hoʻoweliweli kūpono aʻe o ka hypoxia fetal. Ua ʻāpono ʻia kēlā mau koho, ʻoiai ua ʻoi loa ka pōmaikaʻi o ka makuahine a me ka pēpē i nā mea kūpono ʻē aʻe āpau o ka pentoxifylline.

Ua kuhikuhi ʻia me ka mālama ʻana i nā wahine hāpai i ka mōʻaukala o ka UBI a i ʻole ulia duodenal, a me nā mea he haʻahaʻa haʻahaʻa koko. Eia kekahi, pono e kāpae ʻia ka lāʻau lapaʻau i ka hopena o ka manawa hāpai i ka hopena o ke koko i ka wā o ka hānau hānau. Ma keʻano holoʻokoʻa, e like me kāna analogues, i hoʻohana nui ʻia i ka gynecological, hana o ka obstetric ma ke ʻano he vasodilator maikaʻi loa ʻaʻole i kahi hopena pathological i ka hoʻomohala ʻana.

ʻLoe a me ke kākele

ʻO ka hoʻoponopono dosage a me ka dosage hilinaʻi i ka nosology a me ka paʻakikī o ka maʻi. ʻAʻole hiki i nā koho ʻōiwi i kēia mana, akā naʻe, aia nā manaʻo ākea i hāʻawi ʻia i lalo nei.

ʻO ka ʻos a a me nā hoʻoponopono e like me nā ʻano:

1. Pūnaewele papa. Lawe ʻia ka lāʻau lapaʻau ma hope o ka ʻaina, inu i kahi papa me ka ʻole o ka haki ʻana, me ka nui o nā wai (wai)
2. Pono ka hoʻoholo ʻana o ka male ʻana ma ke ʻano - ua ʻā inu ka papa i ka manawa like o ka lā
3. ʻO ka dosis mua o ka lāʻau ka 200 milligrams ʻekolu mau manawa i ka lā
4. Me ka hōʻike ʻana o nā hopena hopena, e hoʻemi ana ka lāʻau ma ke ʻano e like me ka regimen - 100 mg 2 mau manawa a ma nā kikeke. Ma hope o nā lā 3-4, hiki i ka 100 mg ke lawe ʻia ʻekolu manawa i ka lā
5. Pono e hoʻonui ka nui o kēlā me kēia lā nui 1200 milligrams
6. Lawe ʻia ʻo Agapurin retard (lāʻau i lōʻihi) i ka pinepine pinepine - ʻo 1-2 mau manawa i kēlā lā i kēia lā, e like me nā hōʻike
7. Hiki ke lawelawe ʻia nā ʻōkuhi ʻana i ka intramuscularly a i ʻole intravenously:

• Intramuscularly 100mg 102 mau lā i kēlā me kēia kala
• Intravenously - hoʻoheheʻe ʻia ka lāʻau i 250 a i ʻole 500 ml o ka sodium chloride (ma ke ʻano he koho ma kahi ʻōhua o ka glucose - 5%). He lōhū ke ala o ka hoʻokele, ʻaʻole i kiʻekiʻe i ka 150 milliliters i hoʻokahi hola. ʻO ka nui loa o kēlā me kēia lā o ka injectable Agapurin he 2 ampoules
• Ka huina intraarterial - hoʻopau ʻia nā ampou ma 20 a 50 mauʻaena o ka sodium klorida. Pono e hoʻolauna ʻia ka hoʻomaka, pālua ampoule - 10 mau minuke. ʻO ka nui loa no ka lā ma 3 mau ampoule i kēlā me kēia lā
• ʻO ka lōʻihi o ka mālama ʻana ke kau nei i ke kiʻi kauka o ka maʻi a me ka hopena therapeutic i manaʻo ʻia.

ʻAʻole kuhi kēia mau loiloi a ʻaʻole hiki ke noʻonoʻo ʻia he palapala kuhikuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau. Kuhi ʻia ke ʻano o ka noi a me ka ʻōmole ma ke kauka komo e like me ke ʻano o ka mea maʻi a me nā hōʻailona o ka maʻi ʻimi vascular path.

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ʻO ka pilina me nā lāʻau lapaʻau ʻē aʻe

Ma muli o ka lāʻau lapaʻau ma muli o kona pharmacodynamics, hiki i ka lāʻau lapaʻau ke hiki ke hoʻopiha i nā lāʻau antihypertensive, vasodilators, synthetic amines (ganglion blockers). No laila, ʻo nā lāʻau lapaʻau āpau e hiki ke hoʻopilikia i ka coagulation koko, ʻoiai e lawe ana, e hoʻomaikaʻi i kā lākou hopena, e hōʻeha i ka hopena synergy. ʻO nā anticoagulants kūmole a pololei, nā mākaukau e pili ana i ka waila valproic, kekahi mau ʻano o nā lāʻau lapaʻau, ka nui o nā cephalosporins i hui pū me Agapurin hiki ke hoʻonāukiuki i nā hōʻailona ʻaoʻao, ʻaʻole pono kēia e noʻonoʻo i ka wā e kuhikuhi ana i kēlā mau lāʻau.

Nā pilina pili me nā lāʻau ʻē aʻe:

1. Hoʻonui i nā hana pono:

• I ka hui pū me ka thrombolytics
• Me ka hoʻomohala pinepine ʻana o nā lāʻau antihypertensive
• I ka hui pūʻana me nā mea hana a i ʻole nā ​​lāʻau hypoglycemic ʻē aʻe i loko o ka pā papa palapala
• Me ka hoʻokolohua hui ʻana me cephalosporins (cefoperazone, cefamandol, cefotetan)
• I ka hui me PVC - valproate (Depakin, Valparin, Konvuleks)

1. Kuhi me ke akahele me nā lāʻau lapaʻau:

• I ka hui pū me cimetidine, hiki i ka nui o ke kumuhana o ka hana ikaika (pentoxifylline) i loko o ke kōpana koko.
• ʻO ka hui like o Agapurin a me nā hoʻomaʻemaʻe ʻē aʻe, hiki i ka xanthines ke hoʻonāukiuki i nā hopena ʻaoʻao mai ka pūnao o ka pūnao (hoʻonui i ka mana o ka nīkini)
• I ka hui pū me nā lāʻau anti-asthma (theophylline), nā hopena hopena e alualu i ka ʻano o nā inhibitor phosphodiesterase e ulu - hele wale, maʻiʻeha, ʻehaʻeha, ʻeha, epileptoid state

No ka wikiwiki ʻo Agapurin i ka hana o nā lāʻau lapaʻau i hoʻolālā ʻia e hoʻohaʻahaʻa i ke koko, pono ia e hōʻoia i kēlā hui like ʻole i hoʻonāukiuki i ka pīhoihoi i loko o ke koko i lalo (hypotension). Eia kekahi, ʻo ka hoʻohana lōʻihi ʻana o ka xanthines hiki ke hoʻokaʻawale i nā hopena o nā lāʻau hypoglycemic, a me ka insulin, i kēlā mau ʻano, ke hoʻoponopono ʻia ka mālama antidiabetic a me ka mālama mau loa ʻana i nā pae kōleʻa o ke koko e hoʻolako ʻia e pale i ka hypoglycemia. Me ka hoʻomohokoke ʻana o Agapurin a me thrombolytics, ʻo ka PTV (prothrombin manawa) a me IPT (prothrombin index) e hana mau ʻia e pale aku i ka hopena o ka ʻōpū a me ka hemorrhage.

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