Metformin Richter: nā ʻōlelo no ka hoʻohana ʻana i ka lāʻau lapaʻau, kumukūʻai a me nā contraindications

Metformin Richter: nā ʻōlelo no ka hoʻohana ʻana a me nā loiloi

ʻLelo Latin: Metformin-Richter

ATX Code: A10BA02

Pūnaewele: metformin (metformin)

Mea Hana: Gideon Richter-RUS, AO (Lūkini)

Hoʻohou i nā wehewehe a me nā kiʻi: 10.24.2018

ʻO nā kumukūʻai ma nā lāʻau lapaʻau: mai ka 180 rubles.

ʻO Metformin-Richter kahi mea lapaʻau hypoglycemic no ka hoʻopale waha, ʻo ia kahi o ka hui biguanide.

E hoʻokuʻu i ke ʻano a me ka ʻano

Hoʻohana ʻia ka lāʻau lapaʻau ma ke ʻano o nā papa kiʻi ʻoniʻoni kiʻi: biconvex, pōʻai (500 mg) a i oblong (850 mg) paha, keʻokeʻo ka ʻili a me ka ʻāpana ʻōpala (10 pcs. I loko o kahi pā kuhi, 1/4 a i ʻole 6 mau pā i loko o kahi pahu pahu) . ^ E Ha yM.

Pākaukau 1 papa:

mea hoʻonaʻauao: metformin hydrochloride - 500 a i ʻole 850 mg,
Nā kumuhana hou: polyvidone (povidone), copovidone, magnesium stearate, prosalv (colloidal silicon dioxide - 2%, microcrystalline cellulose - 98%),
palani ka film: opadry keʻokeʻo II 33G28523 (hypromellose - 40%, titanium dioxide - 25%, lōpose lactose - 21%, macrogol 4000 - 8%, triacetin - 6%).

Lapaʻau lāʻau

Hoʻololi ʻo Metformin i ka papa o ka gluconeogenesis i loko o ka puʻuwai, e hōʻemi ana i ka lilo ʻana o ka glucose i loko o nā ʻōpū, kōkua i ka hoʻonui ʻana i ka hoʻohana ʻana i ka maʻi peripheral a hoʻonui i ka hoʻoweliweli ʻana o ka iwi i ka insulin. Me kēia, ʻaʻole pili ka waiwai i ka hoʻokumu ʻana o ka insulin e nā β-cell o ka pancreas a ʻaʻole i alakaʻi i ka hoʻomohala ʻana o nā hopena hypoglycemic.

ʻO ka lāʻau lapaʻau ka hōʻemi o ke kiʻekiʻe o ka lipoproteins haʻahaʻa haʻahaʻa (LDL), triglycerides a me ka kolamu holoʻokoʻa i loko o ke koko.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua hoʻoili ʻia ka lāʻau mai ka gastrointestinal tract (GIT). Ka hoʻokūkū nui o ka waiwai (C_max) i ka plasma koko i nānā ʻia ma hope o nā hola he 2,5, bioavailability 50-60%. ʻAi ʻai ʻana i ka C_max metformin e 40%, a hoʻopau i kona hoʻokō ʻia e 35 mau minuke.

Ka Hoʻolaha Mahele (V_{e d}) i ka wā e hoʻohana ai i ka 850 mg o ka waiwai he 296-1012 lita. Hoʻohālikelike ʻia ka paana e ka neʻe wikiwiki ʻana i nā ʻili a me kahi haʻahaʻa haʻahaʻa loa i nā hāmeʻa plasma.

He mea liʻiliʻi loa ka hoʻololi ʻana o ka metabolic o ka metformin, hoʻoiho ʻia ka lāʻau lapaʻau e nā keiki. I ka poʻe olakino olakino, ʻo ka wehe ʻana o ka waiwai he 400 ml / min, ʻo ia ka 4 manawa ʻoi aku ka nui ma mua o ka clearance creatinine (CC), hōʻoia kēia i ka noho ʻana o ka hana huna tubular ikaika. Ka hapalua ola (T_½) - 6.5 hola.

Nā Hoʻohui

maʻi maʻamau precoma, coma,
maʻi maʻamau ketoacidosis,
hana maʻi o nā aʻehā (CC ma mua o 60 ml / min),
hōʻike ʻia nā maʻi i nā maʻi ma ke ʻano a me ke ʻano maʻi i hiki ke hoʻonāukiuki i ka hoʻokō ʻana o ka maʻi hypoxia (ʻeha myocardial infarction, heart / respiratory failed, etc.),
nā maʻi maʻi pū ʻia e ka hopena o ka hana ʻalopō i nele i nā maʻi: nā maʻi lēʻeha loa, ke kanapa, ke kanesa, hypoxia (nā maʻi bronchopulmonary, nā maʻi renal, sepsis, pīhoihoi), kūwaho (e kū'ē i ka luaʻi, ʻehaʻeha),
hana paʻa o ka ate,
lactic acidosis (me ka mōʻaukala)
nā huapoʻi pōpilikia huakino, ke kūpaʻa maʻamau
nā hōʻeha a me nā hōʻiliʻili koʻikoʻi kahi i hōʻike ʻia ka lāʻau lapaʻau,
hoʻohana no ka liʻiliʻi he 2 mau lā ma mua a 2 mau lā ma hope o ka hoʻokō ʻia ʻana o nā haʻawina radioisotope a me x-ray e hana ʻia ai kahi ʻano ʻoi iodine e pili ana i ka maʻi.
glucose-galactose malabsorption, lactose intolerance, hemahema lactase,
ka pono o ka ʻai hypocaloric (ʻoi aku ma mua o 1000 kcal / lā),
hapai a me lactation,
hypersensitivity o kekahi o nā lāʻau o ka lāʻau.

ʻAʻole ʻōlelo ʻo Metformin Richter i nā maʻi no nā makahiki 60 mau makahiki e hana i ka hana kino kino.

ʻO nā waiwai Pharmacological

ʻO ka Metformin-Richter kahi lāʻau lapaʻau e hoʻohana ai e mālama i ka non-insulin-dependant and diabetes. Hiki i ka lāʻau lapaʻau ke pale i ka kaʻina o ka metabolic i loko o ke kō, kahi e alakaʻi ai i ke kūmole o ka glucose, e hoʻoneʻe ana i ka nānā ʻana mai o ka dextrose mai loko mai o ka ʻōpū, hoʻonui i ka hikiwawe o nā palaka a me nā huina o ka hormone protein o ka pancreas.

ʻAʻole pili ka lāʻau lapaʻau i ka hana o ka insulin e ka pancreas, a ʻaʻole pū kekahi i ka hopena o ka hypoglycemia. ʻAʻole kōkua ka lāʻau lapaʻau i ka hoʻonui ʻana i nā manaʻo o ka hormone protein o ka pancreas, hiki iā ia ke hana i ka hoʻonui ʻana i ke kaupaona kino, me nā hōʻike ʻana o nā hoʻopiʻi i nā maʻi maʻi maʻi. Ke kōkua nei ka lāʻau lapaʻau e hoʻoliu i ka paona kino.

Hoʻonui ka Metformin Richter i ka hoʻoneʻe ʻana o nā triacylglycerides a me nā lipids i ka serum o ke koko, hōʻemi i ke kaʻina hana o ka momona oxidation, paipai i ka hana o nā alakaola monobasic carboxylic acid, he hopena maikaʻi i ka hana o ka puʻuwai a me nā kīʻaha koko, a ke kāohi nei i ke kaʻina o ka hōʻino i nā kīʻaha koko nui a liʻiliʻi i ka maʻi mellitus.

Kau ʻia kekahi lāʻau lapaʻau no ka hoʻokō kūloko, ʻike ʻia ka nui o ka nui ma hope o nā hola 2.5. Eono mau hola ma hope o ka hoʻokele ʻana, hoʻomaka ka lāʻau lapaʻau e hoʻoiho iki ʻia mai ke kino, e hōʻemi ana i nā manaʻo o nā mea i hoʻopau ʻia i ke kino. Me ka hoʻohana mau ʻana i ka lāʻau lapaʻau, ʻaʻole mau ka loli o nā māhele o ka lāʻau i loko o ke kino e hoʻopilikia maikaʻi ʻia i ka dinamics a me ke ʻano o ka maʻi. Ke hoʻohana nei i ka lāʻau lapaʻau i ka wā ʻai, e hoʻemi ʻia ka lāʻau o ka ua nui o ka Metformin-Richter i ke kino.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

Hana ʻia ka lāʻau lapaʻau i kahi papa papa, i uhi ʻia me ka kiʻi ʻāpana. ʻO ka momona molekala o ka waiwai ikaika i loko o nā papa he 0,5 a he 0.85 gram paha. Aia ka pahu i kahi mea 30 a 120 paha papa, ma kahi, e hoʻopili ʻia nā kuhikuhi no ka hoʻohana ʻana. ʻO nā mea kiko o ka lāʻau lapaʻau ka mea like penei:

metformin

māhu

hoʻohuihui stearic magnesium,

ka leʻaleʻa talcum.

Nā hōʻailona no ka hoʻohana ʻana

Hoʻolako ʻia ka lāʻau no nā mea maʻi me ka non-insulin-depend-non and non-insulin-diabetes. Hoʻohana ʻia ka lāʻau lapaʻau ma ke ʻano he lāʻau kū hoʻokahi i ka mālama ʻana, ʻo ia hoʻi no ka lāʻau paʻakikī. Eia kekahi, ua kuhikuhi ʻia ka lāʻau lapaʻau i nā mea maʻi me ka momona nui ma ka wā maʻi, pono e kaohi i ka mālama ʻana o dextrose, polycystic ovary syndrome.

Nā hopena hopena

ʻO ka lawe ʻana i ka lāʻau lapaʻau ke kumu i nā hopena ʻaoʻao:

mual o ka loiloi

heʻahe ʻauʻau

haki

ʻeha i ka ʻōpū,

lilo ka momona

ka hoʻāʻo ʻana o ka moʻala ma ka lua waha.

ulaula nui o ka ʻili i māhuahua ʻia ʻana o nā capillaries,

ka hoʻoemi ʻana o ka cobalamin,

ka hoʻohaʻahaʻa ʻana i ka cobalamin i loko o ke koko,

ka haʻalele ʻana o ke kaʻina hana o ke koko,

Hoʻohui Addison-Birmer.

Ke ʻano a me nā hiʻohiʻona o ka hoʻohana ʻana

Loaʻa ka lāʻau Metformin-Richter i ke ʻano o nā papa i manaʻo ʻia no ka hoʻokō kūloko o ka waha. ʻAʻole hiki iā ʻoe ke hōʻoki, wawahi, nahā, kope, a pipi hoʻi i nā papa, pono e hoʻopau ʻia a pau, holoi ʻia me ka wai inu ʻawaʻawa. ʻO ka papa ʻai lāʻau i kēlā me kēia lā, a me ka lōʻihi o ke olakino, ua hoʻoholo ʻia e ke kauka hele ʻana ma hope o ka hōʻike ʻana, hōʻiliʻili ʻana i nā hoʻokolohua a me ka hoʻoholo ʻana i ke kiʻi kauka maoli o ka maʻi. Eia kekahi, hāʻawi i nā noi no ka hoʻohana o ka lāʻau lapaʻau i nā kuhikuhi i hoʻohana ʻia. No ka liʻiliʻi i ka hōʻemi o nā hopena ʻaoʻao, pono e hoʻokaʻawale i ke ʻano loea i kēlā me kēia lā i kekahi mau dosis. ʻO ka maʻi me nā papa me ke kumu molekula ʻo 500 mg: ʻO ka nui o ka lā i kauoha ʻia he 500-1000 mg. Ma hope o nā lā 10-15 o ka hoʻokele ʻana, ua manaʻo ʻia e hoʻonui i ka dosage, e pili ana i ka ʻano o ka dextrose i loko o ka serum koko. ʻO ka palena nui o kēlā me kēia lā he 3000 mg. ʻO ka maʻi me nā papa me ke kumu molekula 850 mg: ʻO ke ʻano i kēlā me kēia lā i ʻōlelo ʻia he 850 mg a i hoʻokahi papa pākaukau. Ma hope o nā lā 10-15 o ka hoʻokele ʻana, ua manaʻo ʻia e hoʻonui iki i ka dosis, ma hope o ke ana ʻana i ka dextrose i ke koko. ʻO ka palena kiʻekiʻe o kēlā me kēia lā he 2550 mg. ʻAʻole pili ka lāʻau i ka monotherapy i ka hiki ke alakaʻi i nā kaʻa, a me ka wikiwiki o ka hopena psychomotor a me ka hoʻokalakipua. Me ka hoʻolālā paʻakikī, ʻoi aku ka maikaʻi o ka haʻalele ʻana i ka hoʻokele a me ka hana e pono ai ka makaʻala. A ʻōlelo ʻia nā poʻe maʻi kahiko e kuhikuhi i kahiʻoi aku ma mua o 1000 mg o Metformin-Richter. ʻAʻole hiki iā ʻoe ke kuhikuhi i ka lāʻau lapaʻau i nā poʻe maʻi e ʻoi aku kona mau makahiki he 60, ʻoiai inā he mau maʻi ʻē aʻe a me nā mea e pili ana i ka hiki ke lawe i ka lāʻau. ʻAʻole hiki iā ʻoe ke kuhikuhi i ka lāʻau lapaʻau Metformin-Richter me ka maʻi ʻeha a me nā maʻi ʻōʻai.

Hoʻolaha ka waipuna

ʻAʻole hiki ke hoʻohui ʻia ka lāʻau Metformin-Richter me ka hoʻohana ʻana i nā mea inu ʻawaʻī, ʻoiai hiki i kēia ke alakaʻi i ka nui o nā hopena o ka hopena a me ka coma lactic. Eia kekahi, loaʻa ka waiʻona wai inu i ka nui o ka hana ma ka hana a nā mea kūwale o loko, e koi ana iā lākou e hana i kahi ʻano hoʻonui, no laila, e hoʻonui ka ulu ʻana o ka hypoglycemia.

Hoʻopili me nā lāʻau lapaʻau ʻē aʻe

ʻAʻole pono e hoʻohana ʻia ka lāʻau Metformin-Richter i hui pū me kekahi mau lāʻau ʻē aʻe.

Hoʻonui ka Danazolum androgen i ka nui o ka piʻi o ka glucose koko,

ka hoʻonuiʻana o ka antipsychotic Chlorpromazinum me ka hoʻonui nui o ka dextrose,

nā lāʻau antidiabetic synthetic, hoʻomākaukau e loaʻa ana i ka salicylic acid, hypoglycemic drug Acarbosum, insulin, non-steroidal anti-inflammatory drug, monoamine oxidase inhibitors, angiotensin e hoʻohuli ana i ka enzyme inhibitors, fibrates, cytotoxic anticancer drug Cyclophosphamidum hoʻonui i ka hopena

ʻO nā lāʻau lapaʻau anti-inflammatory o ka steroid, nā hana hoʻohālikelike o ka waha, ka adrenal medulla hormone Epinephrinum, sympathomimetics, glucagon, thyroid e hoʻoikaika ana i ka hormone, diuretics, antipsychotics, niacin derivatives e hōʻemi i ka glucose,

Hoʻonui ka lāʻau antihypertensive Nifedipinum i ka hoʻomohala ʻana o nā māhele o ka lāʻau a pale i ka manawa o ka hōʻaiho ʻana i ka lāʻau mai ke kino

ʻO Cimetidinum H2-histamine receptor blocker ka hoʻonui aʻe ʻana i ka hopena o ka coma lactic,

potassium-sparing diuretic Amiloridum, cardiac glycoside Digoxinum, alkaloid opium Morphinum, antiarrhythmic drug Procainamidum, alkaloid bark o ka chininum tree Chinidinum, antipyretic drug Chininum, antiulcer drug Ranitidin, diuretic drug hiki ke hoʻonui i ka hopena o ka hoʻomohala ʻana i ka lāʻau Triamtum nā hopena.

Ke keu

Hiki i ka Medication Metformin-Richter ke hoʻoiho i ka hoʻoinu inā inā ʻoi aku ka nui o ka lāʻau i manaʻo ʻia a ʻo ka lōʻihi o ke kau ʻana. Nā hōʻailona hōʻailona o kahi overdose:

lactic acid coma me ka make hou,

nā maʻi hanu

mual o ka loiloi

haki

heʻahe ʻauʻau

hōʻemi iki

ʻeha i ka ʻōpū,

ʻāʻā naʻau

ʻākio

nā maʻi vestibular

nā mea kūlike ʻole

koma

make. Inā loaʻa nā hōʻailona o ka hoʻohālikelike me kahi lāʻau lapaʻau, pono e kūkā koke ʻoe i kāu kauka e hāʻawi i ka hōʻoki maʻi manawa. ʻAʻole hiki iā ʻoe ke hōʻalo i nā hōʻailona o kahi overdose ma kāu iho, pono e mālama ʻia ka mea maʻi a mālama i lalo o ka mālama o ke kauka. ʻO ka lawe ʻana i ka lāʻau lapaʻau e pono e hoʻopau koke.

ʻO nā hua lāʻau i lalo ka mea i hoʻohālikelike i ka lāʻau Metformin-Richter i loko o nā mea kanu a me ka hoʻopili.

Metformin-Richter,

Metformin-Teva,

Bagometua,

Lōʻai,

Metfogamma,

ʻO ka Hoʻonanea

Metopananin,

Siofor,

Glycomet,

Hoʻolaulau

Vero-Metformin,

Hoʻomaka

Gliminfor

Hopu,

Aliia,

ʻO Glibenclamide.

Nā kūlana mālama

Noea ka lāʻau Metformin-Richter e mālama i kahi wahi i kahi kaʻawale ʻia mai ka hiki ʻana o nā keiki a mālamalama i kahi wela ʻaʻole iʻoi aku ma mua o 25 tikelika Celsius. ʻO 3 mau makahiki mai ka lā i hana ʻia ai ke ola o ka noho o ka lāʻau. Ma hope o ka lā e pau ai a me ka waiho ʻana, ʻaʻole hiki ke hoʻohana ʻia ka lāʻau lapaʻau a pono e hoʻokuʻu ʻia e like me nā kūlana maʻi. Nui nā ʻōlelo e pili ai ka hoʻohana ʻana i ka ʻike kikoʻī e pili ana i nā kānāwai mālama a me nā rula.

Ke laikini laikini LO-77-02-010329 i a Iune 18, 2019

Nā hopena hopena

metabolism: loaʻa - lactic acidosis (pono ka hoʻoneʻe ʻana i ka lāʻau), me kahi papa lōʻihi - hypovitaminosis B₁₂ (no ka malabsorption)
pānaʻi ʻona: ke nele o ka makemake, ka momona metala i loko o ka waha, ka luaʻi, ka ʻōpū, ka ʻōpū, ka ʻōpū o ka ʻōpū, ka lemulewa (ʻo kēia mau maʻi ua ʻike ʻia ma ka hoʻomaka ʻana o ka hopena a maʻa mau aku lākou ma o lākou iho, hiki ke hoʻemi ʻia kā lākou kaumaha ma ka hoʻohana ʻana i nā antispasmodics, m-anticholinergics, antacids) , ʻeha - hepatitis, hana ʻoi aku o ka transaminases hepatic (nalowale ma hope o ka pau ʻana o ka mālama ʻana)
ʻoihana endocrine: hypoglycemia,
hematopoietic ʻōnaehana: i nā hihia ʻehā - megaloblastic anemia,
maʻi kūlohelohe: ʻeha, ʻiliʻoki.

Nā ʻōlelo kikoʻī

I ka wā o ka mālama ʻana me ka lāʻau lapaʻau, koi ʻia ʻo ia ma ka liʻiliʻi he ʻelua a i ka makahiki (a me ka hihia o ka myalgia) e hoʻokumu i ka ʻike ʻana o ka lactate i loko o ke koko koko.

Pono hoʻi e hoʻoholo i ka pae o ka serum creatinine i hoʻokahi manawa i kēlā me kēia 6 mahina, he mea koʻikoʻi kēia no nā mea maʻi.

Inā hoʻomohala ʻia ka hanana ʻana o ka luhi infectious o nā genitourinary organitions a bronchopulmonary infection i ka wā o ka mālama ʻana o ka metformin, wikiwikiʻo ia e hōʻike i ke kauka hele e pili ana i kēia.

Pono ke kāpae ʻia ka lāʻau lapaʻau e hoʻopau ʻia he 48 mau hola ma mua a he 48 mau hola ma hope o ka urography, intravenous angiography, a i ʻole kekahi haʻawina radiopaque ʻē aʻe.

Hiki ke hoʻohana i ka Metformin Richter e hui pū me nā derivatives o ka sulfonylurea, ka mea nui i ka wā e pale ana i ka kao o ka glucose i loko o ke koko.

I ka wā o ka papa hana, e ʻōlelo ʻia e hōʻalo i ka lawe ʻana i ka mea inu kīpana a me ka wai lāʻau. Ka hoʻoweliweli ʻana o ka hoʻoweliweli o ka lactic acidosis e ka maʻi ʻawaʻawa o ka ʻawaʻawa, keu i ka hāʻule ʻana o ka pūpū o ka ate, ma muli o ka ʻai haʻahaʻa a kāloli ana.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a me nā mīkini paʻakikī

ʻAʻole hiki i ka hoʻohana ʻana o ka Metformin-Richter me kahi lāʻau monotherapy e hoʻopilikia i ka hiki ke lawe i nā kaʻa.

Ma ka hihia o ka hui pū ʻana o ka metformin me ka insulin, derivatives sulfonylurea a me nā mea hana antidiabetic e pili ana, hiki i ka hoʻomohala ʻana i nā kūlana hypoglycemic, e kū'ē i ka hiki ke hoʻomālamalama i nā ʻenehana paʻakikī (e komo pū ana nā ʻenehana kaʻa).

ʻŌpū a me ka lactation

ʻAʻole pono ke lawe ʻia ka lāʻau lapaʻau i ka wā o ka wā hāpai. Ma ka hanana e ulu ana ka wā hāpai i ka wā o ka mālama ʻana, a ma ka hoʻolālā ʻana, e hōʻoki ʻia ʻo Metformin-Richter a pono e kuhikuhi ʻia ke ʻano o ka insulin.

ʻOiai ʻaʻole ʻikepili e pili ana i ka hana ʻana o ka metformin i ka waiū umauma, he contraindicated no nā wahine e hāpai ana i ka ʻōpū o ka wai. Inā lawe ʻia ka lāʻau lapaʻau i ka wā o ka lactation, pono ke hoʻokuʻu ʻia ka umauma.

Hoʻohui nūhou

Me ka hoʻohana pū ʻana o ka Metformin-Richter me kekahi mau lāʻau lapaʻau / mākaukau lāʻau, hiki i nā hopena pili e pili ana i ka ulu ʻana:

Danazol - ʻike ʻia ka hopena hyperglycemic a kēia māku, ʻaʻole i kuhi ʻia kēia hui, inā ʻoe e pono ai i ka ʻoihana ʻo Danazol a ma hope o kou lawe ʻana, pono ʻoe e hoʻololi i ka hopena o ka metformin a kāohi i ke kiʻekiʻe o ka glycemia.
angiotensin e hoʻohuli ana i ka hoʻōla o ka enzyme, oxytetracycline, monoamine oxidase inhibitors, non-steroidal anti-inflammatory drug, salicylates, sulfonylureas, insulin, acarbose, fibroic acid derivatives, beta-adrenergic blocking agents, cyclophosphamide - hoʻonui hypoglycemic,
chlorpromazine (antipsychotic) - i ka lawe ʻana i kēia lāʻau lapaʻau i kēlā me kēia lā o ka 100 mg, e hoʻonui ka nui o ka glucose i ke koko a hoʻemi ka hoʻokuʻu ʻana i ka insulin, me ka chlorpromazine a me nā ʻano antipsychotics, a me ke ʻano o ka pau ʻana o kā lākou lawelawe, pono ke hoʻoponopono ʻia ka nui o ka metformin a ʻike ʻia nā kaila o ke koko.
cimetidine - ke emi ʻana o ka haʻalele ʻana o ka metformin, no ka mea i hoʻoweliweli ʻia ai ka hoʻoweliweli o ka lactic acidosis.
contraceptives waha, glucocorticosteroids, epinephrine, glucagon, sympathomimetics, hoʻomākaukau ʻana i nā iodine-pili i nā hormones thyroid, loop a me nā thaizide diuretics, derivatives acid nicotinic, derivatives phenothiazine - ua hoʻemi ʻia ka hopena hypoglycemic o metformin,
nifedipine - hoʻonui i ka hoʻowalewale a me C_max lohi me metformin i ka hope,
Iodine i loko o nā ʻaina ʻokoʻa - me ka hoʻokele intravascular o kēia mau mea, e hiki mai ana nā metformin cumulation, hiki iā ia ke hana i ka acidosis lactic,
anticoagulants kūlike (derivin Coumarin) - i nāwaliwali o ka hopena,
ranitidine, quinidine, morphine, amiloride, vancomycin, triamteren, quinine, procainamide, digoxin (cationic drug huna ʻia e nā tubula renal) - he hiki ke hoʻonui i ka C me kahi papa lōʻihi_max 60% metformin (ma muli o ka hoʻokūkū no nā ʻōnaehana ʻoihana tubular).

The analogues of Metformin-Richter are: Glyformin Prolong, Bagomet, Glyformin, Glucofage, Diasfor, Glucofage Long, Diaformin OD, Metfogamma 500, Metadiene, Metfogamma 850, Metformin long, Metformin-Kanon, Metformin, Metformin Zentiva MV, Metforminformiva , Metformin Sandoz, Metformin-Teva, Siofor 500, Formin, Sofamet, Siofor 850, Formin Long, Siofor 1000, Formin Pliva.

Nā Hōʻikeʻike iā Metformin Richter

E like me ka nui o nā loiloi, ʻo Metformin Richter kahi lāʻau lapaʻau e hoʻoponopono i ka kaila o ka glucose i loko o ke koko, e hoʻemi ana i ka makemake a me nā mea makemake i nā sweets, a kōkua e hoʻemi a hoʻonā i ka paona ʻana.

ʻO nā hemahema o ka lāʻau lapaʻau, nui nā mea maʻi e komo i ka hoʻomohala ʻana o nā hopena kūwaho (ʻoi aku mai ka gastrointestinal tract) a me kahi helu nui o nā contraindications. Ma ka aneane o nā loiloi, ua hōʻike ʻia he koʻikoʻi koʻikoʻi ʻo Metformin-Richter a he mea pono ke lawe wale ma ke ʻano he kuhikuhi ʻana e ka loea.