Ke ʻano lāʻau Akkuzid: nā ʻōlelo no ka hoʻohana ʻana

ʻO ka hopena hoʻohui me ka hopena antihypertensive, aia kahi ʻelua mau mea ikaika: quinapril (ka mea paʻa ACE) a ā huinahui (diuretic) ʻekolu mau hui hoʻohui.

Hinapril Kapiliʻili synthesis angiotensin IInā mea e hoʻoulu ai i ka cortex adrenal (hana aldosterone), hoʻopili i ke kani vascular a loaʻa ka hopena vasoconstrictor. Hinapril kāohi ACE (ka kiko a me ka piʻipiʻi) a hōʻemi i ka hana vasopressor a me ka hoʻopā aldosterone. ^ E Ha yM. Ke hooki nei i ka hopena maikaʻiʻole angiotensin II e kūkulu reninalakaʻi i ka hoʻonui i ka hana renin.

Hoʻolaha HANʻI e kū ana i kahi kūlana o ke emi ʻana o ke kūpaʻa o ka val i ka pale a me OPSSi ka manawa like, he loli i ka hopena cardiac, ʻAne hoihoi, kahi kānana glomerular a me ke kahe koko o ka'āwī i keʻelima a paʻa paha. Hinapril hoʻokaʻawale iki i ka nalowale pākia i hana ʻia e ka hana huinahuika mea, he hopena diuretic, hoʻonui i ka hana renin koko, hoʻomaikaʻi i ka mea huna aldosterone, ke hoʻonui i nā ʻike potasi i loko o ke koko a hoʻonui i ka excretion ma o nā keiki. Hoʻopau ka hopena antihypertensive i loko o hoʻokahi hola a hiki i kahi lōʻihi ma hope o 3 mau hola, e hoʻomau ana i ke ao holoʻokoʻa.

ʻO ka hole waiwai - e pili ana i ka hui o nā diuretics, pili i ka hana o nā keiki, hoʻonui i ka excretion o ka sodium, potassium, chlorides, Naona helu bicarbonate a me ka wai me ka hoʻēmi ʻana i ka ʻehuʻī o ka calcium. Hōʻike ʻia ka hopena diuretic ma hope o 2 mau hola, ʻo ke kūpono loa ma hope o 4 mau hola a ʻo kona lōʻihi he 6-12 mau hola.

ʻO nā hui pū me nā mea ikaika (quinapril a huinahui) hāʻawi i ka emi ʻana o ke kahe HANʻIma mua o ka hana o kēlā me kēia.

Lapaʻau lāʻau

ʻAʻole like nā mea ikaika a kekahi i kekahi.

Hinapril - Loaʻa ka Cmax ma hope o 2 mau hola. ʻO ka nui o nā ea e pili ana i ka 60%. Hoʻopili kiʻekiʻe i nā protein koko. I nā ate, ka biotransformed e quinaprilatahe mea pale ikaika ACE. ^ E Ha yM. Mai komo BBB. ^ E Ha yM. Hoʻokuʻu ʻia ia ma o nā maʻamau, ʻo T1 / 2 - mau hola 3.

ʻO ka hole waiwai - ka hoʻoiho ʻana aku i ka haʻahaʻa, ʻo ka pae o ka hoʻāʻo ʻana o 50-80%. Loaʻa ka Cmax i 1-3 hola. Mai komo BBB. ^ E Ha yM. ʻAʻole hoʻohuli ʻia ke kino, excreted i hoʻololi ʻia ma o nā keiki. T1 / 2 - mai 4 a 15 mau hola.

Nā Hoʻohui

• Pono ka naʻau kiʻekiʻe i ka lāʻau,
• iia manamiais - angioedema ma hope o ka maʻi me nā inhibitors ACE,
• ʻO ka maʻi Addison,
• anuria,
• makahiki i 18 makahiki
• maʻi mellitus maʻiʻi,
• hapai a lactation.
• ua haiia hālohelohepūpū hema
• nele lactases.

Akkuzid, nā ʻōlelo e pili ana i ka hoʻohana ʻana (ke ʻano a me ke ʻano)

Lawe ʻia nā papa Akkuzit i hoʻokahi manawa i kēlā me kēia lā me ka ʻole o ka haʻi ʻana i ka ʻai. ʻO ka paipai mua i kēlā me kēia lā no nā maʻi e loaʻa ʻole i ka diuretic ʻo ia he 10 mg + 12.5 mg (hoʻokahi papa o Accuzit 10), inā pono, ua hoʻonui ʻia ka pualikua mua i kēlā me kēia lā i 20 mg + 25 mg (hoʻokahi papa o Accuzit 20). Ma ke ʻano he kānāwai, e hopena ka hopena i ka wā e lawe ai i ka lāʻau lapaʻau i loko o ke ʻano kaʻi ʻana mai (10 +12.5 a 20 +12.5) mg i kēlā me kēia lā. ʻAʻole pono nā poʻe maʻi i ka hoʻoponopono hoʻoponopono ʻia. I ka loaʻaʻana o kahi hana ʻino nui loa i nā maʻi, ʻaʻole pono e hoʻohana ʻia ka lāʻau lapaʻau ma mua o ka lāʻau mua.

Ke keu

ʻO nā mea hōʻike nui o ka overdose me ka hoʻohana lōʻihi ʻana i ka lāʻau lapaʻau i nā pau ʻana e nui i ka therapeutic HANʻI, haunaele i ka wai a me ke kaulike electrolytic, hōʻike ʻia hypochloremia, hyponatremia, hypokalemia.

Hoʻohui

Me ka hoʻomohokoke hiki ʻana o Accuzide me nā antibiotika o ka hui paikiki kaʻina ʻai paikiki hoemi ia e ka hapakolu. ʻAʻole ia e kuhikuhi i nā hoʻomākaukau lithium e hui pū me ka diuretics, ʻoiai me ka diuretics e hoʻohaʻahaʻa i ka hoʻomaʻemaʻe i ka lithium a me ka nui o ka pohō e piʻi maikaʻi. ʻOiai e lawe ana me ka Accid ethanolopioid analgesics, barbiturates a Nā lāʻau lapaʻau c no ka hanana anesthesia ākea ka hopena o ka hoʻomohala ʻana orthostatic hypotension. ^ E Ha yM. I ka manawa like e lawe ana iā Accudis me insulin a i ʻole nā lāʻau maʻi hypoglycemic mea kūpono ʻia kahi hoʻoponopono ʻana o nā mea lawelawe hypoglycemic. ʻO ka hole waiwai ma ka hōʻike ʻo Akkuzid e hoʻonui i ka hana a nā lāʻau antihypertensive i lawe pū ʻia me ia.

Me ka hoʻomohala pinepine ʻana o nā lāʻau corticosteroid me Accuid, he hiki ke hoʻonui ʻia o ka potoma pākahi a me nā mea hoʻokipa ʻē aʻe. Hōʻikeʻike Nā NSAID kumu e hoʻonāwaliwali ai i ka hana antihypertensive, diuretic a me ka hana natriuretic o ka diuretics. Me ka hoʻokolohua ʻōpiopio o ka hoʻomaha ʻoluʻolu me Akkuzid, hiki ke hoʻonui ʻia kā lākou hana.

ʻLoe a me ke kākele

ʻO ka pākaukau maʻamau o Accuid hoʻokahi papa (10 mg / 12.5 mg) i kēlā me kēia lā i kēlā me kēia lā. E hoʻonui i kāu kauka i ka lolo i ʻelua papa i ka lā, hiki ke hoʻohui ʻia i hoʻokahi manawa i ka lā a hoʻokahi ʻokoʻa - kahi papa i ke kakahiaka, kekahi i ke ahiahi.

Lawe mau iā Accuzide e like me ka kauka ʻana e kāu kauka. Mai lawe kaha i nā papa he nui ma mua o ka ʻōlelo a kou kauka.

E ho'āʻo e lawe i nā paila ma ke ʻano like o ka lā i kēlā me kēia lā, me ka ʻole o ka pāʻina.

• Inā poina ʻoe e lawe i kahi mahele o ka lāʻau lapaʻau, e lawe koke iā ʻoe, e noʻonoʻo ʻoe, me ke kali ʻole ʻana me ka manawa aʻe e lawe ʻoe i ka lāʻau lapaʻau. Mai lawe i ʻelua mau papa o ka lāʻau.
• Inā kuhi hewa ʻoe i nā papa Akkuzid he nui, e hoʻomaopopo koke i kāu kauka inā ʻaʻole hiki iā ʻoe ke hana i kēia mea, e kāhea aku i ka ʻoihana keʻena ʻo ka haukapila kokoke loa. Lawe pū i ka pau o ka lāʻau lapaʻau, ʻoiai inā ʻaʻohe nā papa i koe i hiki i nā limahana ke haukapila keʻike maʻalahi i ka lāʻau lapaʻau āu i lawe ai.
• ʻAʻole ʻōlelo ʻia ʻo Accid i nā keiki. ʻAʻole i aʻo ʻia ka lāʻau lapaʻau i nā mea maʻi ma lalo o nā makahiki 18.

Loaʻa ka hopena

E like me nā lāʻau lapaʻau i hoʻohana ʻia no kou maʻi, hiki i ka Accuzide i kekahi manawa i kahi hopena ʻole (hopena hopena). Inā ʻoe e hoʻomohala i kēia mau ʻōuli, pono ʻoe e nīnau me kāu kauka.

• E hoʻomau i ka ʻōpala maloʻo.
• Puka, luwau, maʻi ʻana, constipation, indigestion, flatulence, dyspepsia, or ʻeha ʻeha.
• ʻO ka hōʻeha, ka ʻeha, ka flush, ka insomnia, ke kaumaha, ka luhi, ka ʻoluʻolu a i ʻole ka momona, a i ʻole ka maʻamau maʻamau o ka nāwaliwali.
• ʻEha ma ke kua, umauma, ʻiliʻī, a me nā ʻūʻī (gout).
• ʻO ke ʻano ʻeha, ʻeha a hypersensitivity i ka māmā, ke ʻano kūlohelohe.
• ʻO nā maʻi pēpē (mai ka manawa i ka manawa, inā kauka ke kauka i ka hoʻomohala ʻana o ka maʻi ʻōpiopio, hiki i kāu kauka ke kuhikuhi i nā hōʻike urine).

ʻO nā hopena ʻeha i loaʻa pinepine iki ka: ʻo ka huki nui, ka waha maloʻo a me ka ʻāʻī, ke kaumaha o ka lauoho, ka hemahema, ka maʻi o ka urinary (mucusal dryness hiki ke alakaʻi i ka maʻi), ke aloʻa ʻana i ka leʻaleʻa a i ʻole nā ​​wāwae, nā mea huakaʻi. , hilahila, luhu, tinnitus, pupula blurred, ʻaina ʻoluʻolu, edema (peripheral).

Inā ʻoe e hoʻomohala i kēia mau ʻōuli, pono ʻoe e nīnau me kāu kauka.

Inā ʻoe i kūkulu i kahi kaua o ka dizziness, a laila pono ʻoe e haʻalele i ka hoʻokele a me nā mīkini hou.

Hiki i Accuid ke hoʻololi i kekahi mau loli i ke kiʻi koko. No laila, ua kau koʻikoʻi o kau olakino e kuhikuhi i nā hoʻokolohua koko e nānā i kēia. Inā loaʻa iā ʻoe he pōpilikia, he ʻeha nui ka ʻeha, inā he maʻi maʻi a ʻike ʻoe i ka piʻi ʻana o ke kahe koko, a laila e hōʻike iā ʻoe i kāu kauka a inā pono, e loaʻa iā ʻoe ka hōʻike koko.

ʻAʻole loaʻa nā hopena hope loa, akā hōʻeha loa, no laila inā loaʻa iā ʻoe, e haʻi koke aku i kāu kauka.

• ʻO ka edion Angioneurotic (ka ʻōpū o ka maka, ka alelo, ka trachea - hiki ke hana nui i ka hanu). I ka manawa like, the edion angioneurotic o ka ʻōpū a me nā ʻōpū (kumuleuʻoni angioedema - intestinal edema) e ulu kūʻokoʻa. I kēia hihia, ʻike ʻoe ʻaʻole e kūpaʻa; He ʻano liʻiliʻi loa kēia, akā, he mau hopena koʻikoʻi loa, a inā ʻoe i hoʻomohala iā lākou, pono ʻoe e kāhea koke i kahi ambulance.
• ʻO ka pīhoihoi i ka umauma, ka umauma ʻeha, nā palpitations, me ke ʻano a me ka ʻole o ka hanu.
• ʻO kaʻeha koʻikoʻi a iʻole nā ​​ʻeha ma ka waha. Inā loaʻa iā ʻoe paha nā pilikia o ka pūpū a he pōpilikia paha ʻoe i ka ʻili o ka huakaʻi, e hoʻomohala ʻoe i ka neutropenia / agranulocytosis (ʻaʻole lawa nā keʻena koko keʻokeʻo), ka mea e alakaʻi ai i ka maʻi, ʻehaʻeha, a i ʻole ʻeha paha. Inā loaʻa iā ʻoe ka maʻi ʻokoʻa loulou, ʻike paha kāu kauka iā ʻoe i nā hoʻokolohua koko e nānā i kēia ʻano.
• ʻO ka palahalaha ʻana, inā paha i ke kū ʻana, ʻo ia paha ke ʻano o ke koʻi koko. Loaʻa paha kēia ʻano i ka wā e lawe ai ʻoe i ka diuretics (diuretics), nā lāʻau lapaʻau ʻē aʻe e hoʻemi ana i ke koko, a me ka mea ʻawaʻawa ke kaumaha loa ʻoe a e hele ana paha i ka hemodialysis ke lawe pū ʻoe me Accuzide. Inā i pouli ʻole kou mau maka a e like paha e hele ana ʻoe ma kahi o kou hele ʻana, e hana i kahi kūlana a moe i laila a hala nā manaʻo.
• ʻO nā hopena ʻē aʻe akāʻoi loa paha ka paʻakikī o ka sclera o ka maka a me ka ʻili (jaundice), hōʻeha nui i loko o ka ʻōpū a me hope (pancreatitis), nāwaliwali i ka puʻu i luna a i lalo haʻahaʻa, a i ʻole ka pilikia e ʻōlelo ana (ʻoiai paha i kahi hōʻeha).

Kahawai

Ke hoʻohana nei i ka lāʻau Kūleʻa contraindicated i ka wā hapai, nā wahine e hoʻolālā nei i kahi wā hāpai, a ʻo nā wahine o nā makahiki hānau o ka hoʻohana ʻole i ka hoʻohana pono ʻana o nā hana o ka hopena.
Pono nā wahine o nā makahiki hānau e lawe nei iā Accuside® i nā ala kūpono o ka contraception.
Inā hele i ka wā hāpai i ka wā e mālama ai me Accuzide, pono e hoʻopau ʻia ka lāʻau i ka hiki.
ʻO ke koho ʻana o ka inhibitor ACE i ka wā hāpai ʻia e ukali ʻia ana me ka nui o ka pilikia o ka ulu ʻana i ka nui o nā ʻano maʻi o ka pūnao a me ka pīhoihoi o ka pūpū. Eia kekahi, kūʻē i ka hope o ka hoʻohana ʻana o ka inhibitor ACE i ka wā o ka wā e hapai ai, nā hihia o oligohydramnios, hānau mua, ka hānau ʻana o nā keiki me ka hypotension arterial, hana ʻole o ka māla, ke ʻano o ka hana ʻole o ka māla, ka hypoplasia o nā iwi o ka ʻaukaha, nā aelike o nā wāwae, ka loina craniofacial, hypalardine ulu. , wehe ductus arteriosus, a me nā hihia o ka make a me ka make hou. ʻO ka pinepine, ʻike ʻia ka oligohydramnios ma hope o ka malū o ka ʻōpala.
ʻO nā pēpē hou i hana i ka ʻike intrauterine i ka pale ʻana i ka ACE e pono e makaʻala e ʻike i ka hypotension arterial, oliguria a me hyperkalemia. I ka wā e puka mai ai ka oliguria, pono e mālama ʻia ke kahe o ke koko a me ka hoʻowalewale i ka lua.
Ua kuʻi ʻo Thiazides i ka pāpaʻi placental a loaʻa ia i ke koko o ke kaula umbilical. ʻO nā hopena non-teratogenic o ka thiazides e komo me ka jaundice a me thrombocytopenia o ka pēpē a me / a i keiki hou, a me nā mea e hiki ai i nā hanana ʻino loa i nānā ʻia ma ka pākeke.
ACE inhibitors, me ka hinapril, i kahi palena iki e komo i ka waiū umauma. Hoʻokomo ʻia ʻo Thiazide diuretics i ka umauma umauma. Hāʻawi ʻia i ka hiki ke hoʻomohala ʻeha i nā keiki hou, ʻaʻole pono ʻo Accuzide i ka wā lactation, a inā pono, pono e ʻoki ʻia ka ʻōpū.

E hoʻokuʻu i ke ʻano

pakuhi. lēwila kiʻi, 10 mg + 12.5 mg: 30 pcs.
pakuhi. lēwila kiʻi, 20 mg + 12.5 mg: 30 pcs.
pakuhi. lēwila kiʻi, 20 mg + 25 mg: 30 pcs.

1 papa pākaukauKūleʻa mau nā: quinapril hydrochloride 10.832 mg, e pili ana i nā kiko o ka quinapril 10 mg
hydrochlorothiazide 12.5 mg.
Nā mea hoʻihoʻi: ka lactose monohydrate - 32.348 mg, magnesium carbonate - 35,32 mg, povidone K25 - 4 mg, crospovidone - 4 mg, magnesium stearate - 1 mg.
ʻO ka mana o ka palaka kiʻiʻoniʻoni: opadray ʻulaʻula OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, kaila beʻoniʻoni pōpele melemele, wili aila kahe manuahi i hoʻoneʻe ʻia) - 3 mg, ʻaila hilo - 0,05 mg.
1 papa iā Akkuzid mau nā: quinapril hydrochloride 21.664 mg, e pili ana i kahi kiko o ka quinapril 20 mg.
hydrochlorothiazide 12.5 mg.
Nā mea hoʻihoʻi:: ka lōmole lactose - 77.196 mg, magnesium carbonate - 70.64 mg, povidone K25 - 8 mg, crospovidone - 8 mg, magnesium stearate - 2 mg.
ʻO ka mana o ka palaka kiʻiʻoniʻoni: opadray ʻulaʻula OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, kaila kahelehe ironide, ʻelehe ka wai hao kahe puaʻa) - 6 mg, ʻaila hilo - 0.1 mg.
1 papa pākaukauKūleʻa mau nā: quinapril hydrochloride 21.664 mg, e pili ana i kahi kiko o ka quinapril 20 mg.
hydrochlorothiazide 25 mg
Nā mea hoʻihoʻi:: ka lōmole lactose - 64.696 mg, magnesium carbonate - 70.64 mg, povidone K25 - 8 mg, crospovidone - 8 mg, magnesium stearate - 2 mg.
ʻO ka mana o ka palaka kiʻiʻoniʻoni: opadray ʻulaʻula OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, kaila kahelehe ironide, ʻelehe ka wai hao kahe puaʻa) - 6 mg, ʻaila hilo - 0.1 mg.

ʻLoe a me ke kākele

Kuhi ʻia ʻo Akkuzid no ka hoʻohana waha. Hoʻohui ka hoʻonui ʻana - 1 ka lā i kēlā me kēia lā, ʻaʻohe o ka hoʻokomo o ka meaʻai.

ʻO nā mea maʻi ʻaʻole e hele ana i ka diuretic therapy e kuhikuhi iā Accuzid 12.5 mg + 10 mg papa, 1 pc pākahi. i ka la. Inā kūpono, hiki ke kuhikuhi i ka Accuid 25 mg + 20 mg, 1 pc. i ka la.

E hoʻokō mau ka hoʻopiʻi koko koko kūpono ma o ka hoʻohana ʻana i nā kaila o kēlā me kēia lā o ka lāʻau ma ka awela mai 12.5 mg + 10 mg a 12.5 mg + 20 mg.

Ka hoʻoponopono Dosage no nā hui kūikawā o nā maʻi.

• hikiwawe hana ʻoi aku ka hana o ka hōʻeha ʻeha (ʻo ka hana hōʻemi ma lalo o 60 ml / min): Accuzide 12,5 mg + 10 mg - 1 pc. i ka la
• hana ʻole ʻoi aku ka hopena o ka maʻi hakahaka (ʻo ka cleinine clearance 60-30 ml / min.): ʻo ka inamua mua o ka quinapril he 5 mg me ka hoʻōla hou ʻana, ʻaʻole kau ʻia nā mea maʻi o kēia pūʻulu iā Accuzide e like me ka hoʻouka mua ʻana,
• nā makahiki holomua: Accuzide 12.5 mg + 10 mg - 1 pc. i kēlā me kēia lā, ʻaʻole pono ka hoʻoponopono ʻana o ka inikua.

Nā hopena hopena

ʻO nā hanana ʻino i loaʻa ma mua o 1% o nā mea maʻi e loaʻa ana i ka quinapril i hui pū me ka hydrochlorothiazide.

• ʻōwili paʻahao: hypercreatininemia, hyperazotemia,
• other: headache, dizziness, nausea, vomiting, digestive disorder, muscle pain, chest pain, abdominal pain, back pain, viral impect, bronchitis, sinusitis, pharyngitis, upper respiratory tract infection, unproductive persistent cough nā hōʻailona o ka vasodilation, kaʻilihune, asthenic syndrome, ka ʻōpū.

ʻO nā hanana ʻino i loaʻa i ka 0.5-1% o nā mea maʻi e loaʻa ana i ka quinapril i hui pū me ka hydrochlorothiazide:

• hematopoietic ʻōnaehana: kahi emi i ke kiʻekiʻe o leukocytes, platelets, granulocytes, hemolytic anemia,
• ʻōhumu: nā pōpilikia, ke hiamoe nei, hoʻonui nui ʻia, ka ʻōpū o ka ʻāʻī ʻana a me ka ʻāʻī ʻana o nā wāwae,
• cardiovascular system: palpitations, tachycardia, arrhythmia, angina pectoris, heart failed, myocardial infarction, nui ka hoʻemi ʻana i ke koko, ke orthostatic hypotension, palupalu, ischemic stroke, hypertensive krisis, peripheral edema,
• ʻūnaehana hanu: sinusitis, pōkole o ka hanu,
• digestive system: stool disorders, flatulence, dry mucous membranes of the mouth and throat, angioedema, intestinal edema, pancreatitis, hepatitis, impaired ate function test, ka huhū mai ka ʻeha o ka gastrointestinal,
• kūlohelohe: nā ʻulima o ka ʻili, urticaria, pruritus, edema o Quincke, photosensitivity, Stevens-Johnson syndrome, dermatitis exfoliative, pemphigus, reaksi anaphylactoid, nui loa kahi hana,
• musculoskeletal ʻōnaehana a me ka hoʻopili pili: arthralgia,
• ʻōnaehana genitourinary: urinary tract infection, renal dysfunction, ʻili o ka renal failed, pale ʻana o ka potency,
• hiʻona o ka ʻike: ʻike maka,
• Nā kumuhana ʻē aʻe: hyperkalemia, alopecia, i hui pū me ka mākaukau gula: nausea, luaʻi, helehelena hypial, he hōʻemi i ka pehu o ke koko, nā maʻi like-flu.

ʻO kēia mau hōʻailona aʻe ka ʻano i kahi overdose o Akkuzid: huina i loko o ka wai-paʻakai metabolism, kahi nui o ke kahe koko, ke emi ʻana o ka bcc e pili ana i ke kāʻei o ka diuresis ikaika. I ka hui pūʻana me nā glycosides cardiac, hiki i ka hiki ke hoʻomohala i ka arrhythmias.

ʻO ka maʻi overdose: kaohi ʻana i ka lāʻau lapaʻau, lavage gastric, waha o ka waha o adsorbents, intravenous (iv) keʻena o 0.9% sodium chloride solution, kākoʻo a me ke ʻano maʻi.

Nā ʻōlelo kikoʻī

Aia nā hōʻike o nā hihia o ka angioedema o ka ʻāʻī a me ke alo i ka wā o ka mālama ʻana me nā mea hoʻokae ACE, me ka 0.1% o nā maʻi e loaʻa ana i ka hinapril. I kahi hihia o ka angioedema o ka helehelena, ka ʻōlelo, nā lipole leo, nā maka a me ka uhu laryngeal a me ka pilikia ʻole i ka hanu, ka ʻai ʻana i ka meaʻai, ʻāpono koke ʻia ʻo Akkuzid. Pono ke kanaka e kuhikuhi i ka lāʻau kūpono a nānā i kona kūlana a hiki i nā hōʻailona o ka edema nalowale, hiki ke hoʻohana ʻia nā antihistamines e hōʻemi iā lākou. Me ka angioedema e pili ana i ka larynx, kahi hopena hopena. Inā, ma muli o ka huki ʻana o nā kuʻi leo, lehelehe, a i ʻole larynx, hiki i ka hoʻomohala ʻana o ke ala o ka ala, a laila e pono ke hoʻomoʻi ʻia nā pilikia e hiki ai, me ka hoʻomohala kūloko i ka hopena o ka adrenaline i ka hoʻokaʻawale o 1: 1000 (0.3-0.5 ml).

I ka poʻe maʻi i hala ma mua o ke angioedema i pili ʻole me ka lawe ʻana i nā mea hoʻopaʻa Accuzide a me ACE, e ʻae ʻia ka ulu ʻana o kona ulu ʻana me ka hoʻohana ʻana i nā lāʻau lapaʻau o kēia hui.

Hiki i ka Accuzide ke hoʻoemi i kahi kahe o ka neʻe i ke kō, akā naʻe, ʻaʻole iʻoi aʻe ma mua o ka monotherapy me nā papa hana ʻelua. Hoʻohui ka hapanui hypotension me ka hypertension arterial uncomplicated, akā hiki nō iā ia ke hoʻomohala hou i nā poʻe maʻi me ka hoʻohaʻahaʻa BCC, no ka laʻana, ma hope o ka maʻi diuretic, ma muli o kaʻai paʻakai a i ʻole hemodialysis.

Ma kahi o nā hōʻailona o ka hypotension arterial, pono e moe ka mea maʻi. Inā pono, e hoʻokomo ʻia kahi infravenous infusion o 0.9% sodium chloride solution. ʻO kahi emi iki o ke kahe koko e koi ʻole i ka haʻalele ʻana o Akkuzid, akā naʻe, pono ʻia ka hoʻoponopono hoʻoponopono ʻana.

I nā mea maʻi me ka puʻuwai pu me ka ʻole me ka ʻole o ka hōʻiliʻili ʻana o ka renal flfunction, lawe aku iā Accuzide i kumu no ka hōʻemi i ke kahe o ke koko, i hele pū ʻia e oliguria a me azotemia. I nā hihia pinepine, hiki i ka hoʻomohala ʻana o ka hana kīnā ʻole a hiki i ka make. Pono e lawe ʻia kēia ʻano maʻi i lalo o ka mālama kiaʻi.

Kekahi manuahi, hiki ke hui pū ʻia me ka hoʻohaʻahaʻa ʻana i nā granulocytes i loko o ke koko i ka pae koʻikoʻi a me ka pani ʻana o ka maʻi hematopoiesis, a ʻo ke ʻano o ka leukocytes i ke koko e pono ai e hoʻomalu.

ʻO ke ʻano o nā hōʻailona liʻiliʻi loa o ka maʻi (maʻi, ʻehaʻeha) e hōʻike ana i ka pono ke ʻike i ke kauka, e like me kā lākou e hōʻike ai iā neutropenia.

ʻAʻole i kuhikuhi ʻia ʻo Accuzide no ka hoʻopiʻi ʻana i ka pilikia o ka pilikia (hana i hana ʻia ma lalo o 30 ml / min), no ka mea ua loaʻa ka azotemia a me ka hopena cumulative no ka hoʻohana lōʻihi.

I nā mea maʻi me ka puʻuwai naʻau koʻikoʻi, hiki i ka hoʻohana ʻana o nā inhibitor ACE ke alakaʻi i ka nui o ka hoʻokahe o ke koko, hiki paha i ka emi ʻana o nā nui o ka urine i hoʻopā ʻia e nā ʻōpū a me / a he piʻi nui o ke koko o nā huahana metabolic nitrogenous i hoʻopā ʻia e nā keiki. Ua lanakila ʻole ʻia ka papaha a me ka make ʻole a i ʻole ka make.

I ka wā o ka maʻi me ka Accuside, ka piʻi ʻana o ke koko, hana o ka pēpē, a me nā pae o ka electrolyte plasma e pono ai ka nānā. ʻO ka hoʻohana like ʻana o ka quinapril a me nā mea āpau e kū'ē i ka renin-angiotensin-aldosterone system (RAAS) e pono e pale ʻia. Maikaʻi wale kēia hōʻiliʻili i nā hihia pilikino ma lalo o ka mākaʻi paʻa o ka hana mimi a me nā pae pākela plasma.

I nā mea maʻi me ka maʻi hepatic maʻi ʻole a i ʻole nā ​​maʻi lohi o ka holomua, e hoʻohana ʻia ʻo Accuzide me ka akahele, no ka mea, ʻo nā hoʻololi liʻiliʻi ma ka palau ʻana i ka wai-electrolyte hiki ke hana i ka hoʻomohala ʻana o ka comp hepatic.

Ma kahi o 2% o nā maʻi e mālama ʻia me ka quinapril i loaʻa i ka hyperkalemia. ʻAʻole ʻōlelo ʻia ka hoʻohana pinepine ʻana o Accuzide a me potassium-sparing diuretics.

ʻO ka hemahema o Chloride e pili ana me ka lawe ʻana iā Accuzide e maʻa mau a makemake ʻia i ka hana kūikawā wale nō i nā hihia kaʻawale (me ka laʻana, me nā ala no nā puʻuwai a me / a pūpū paha).

I ka wā wela, e lawe ana i ka Accuzide i nā mea maʻi me ka edip peripheral hiki ke hoʻoulu i ka sodium i loko o ke kino. Pono ke ʻano o kēia ʻano maʻi.

Hoʻopau ʻo Hinapril i ka hoʻonui ʻana o ka calcium, hoʻonui i ka excretion o ka magnesium i loko o ka hoʻomoʻa, e hiki ai i ke hypomagnesemia.

Hiki i ka Quinapril ke hoʻonui i ka kolamu serum, uric acid a me ka triglycerides. ʻO ka maʻalahi o kēia mau hopena, akā, i kekahi mau hihia, hiki iā lākou ke hoʻoulu i ka ulu ʻana o ka gout a me ka maʻi diabetes.

ʻO ka lawe ʻana i nā ʻōhā kiʻekiʻe o Accuzide hiki i ka hyperkalemia (ʻoi aku ka nui o kahi momona o ≥100 mg i kēlā me kēia lā), hōʻole i ka kaohi o ke kahe o ke koko. I ka wā o ka papa hana, e ʻōlelo ʻia e hoʻomalu i ka pae glucose o ka plasma a, inā pono, e hoʻoponopono i ka hana hypoglycemic.

Ma mua o ka hōʻemi ʻana, pono e hoʻomau ka mea maʻi i ke kauka ke lawe nei ʻo ia iā Accuzide.

I ka wā hōʻeha o ka lāʻau lapaʻau, ua hoʻomaopopo ʻia ka hoʻomohala ʻana i ka lāʻau hoʻomau mau ʻole. Hele ia ma hope o ke kāpae ʻana i ka lāʻau.

Hiki i ka Hydrochlorothiazide ke alakaʻi i ka hoʻokumuʻana i nā glaucoma hoʻoweliweli a me nā myopia kaʻawale. Me ka ʻole o ka mālama kūpono, hōʻeha pū ʻia ka hopena o ka glaucoma me ka nalowale o ka ʻike.

Pono nā wahine o nā makahiki hānau inā e hoʻohana ʻia ʻo Akkuzid e pale ʻia mai ka wā hāpai. I ka hoʻomakaʻana o kāna hoʻomaka, hoʻopau kā ka lāʻau koke i ka hiki.

I ka wā o ka maʻi me Accuside, pono e mālama ʻia ka akahele i ka wā e hana ai i nā ʻano hana e pono ai ka nui o ka nānā ʻana a me ka wikiwiki o ka hopena psychomotor, me ka hoʻolima ʻana i kahi kaʻa a me nā mea paʻakikī e ʻano, ka mea nui o ka hoʻomaka ʻana o ka mālama ʻana.

Hoʻohui nūhou

• diuretics: hoʻonui ulu hypotensive o Akkuzid,
• ethanol, derivatives o ka barbituric acid, narcotic analgesics: hoʻonui koʻikoʻi o ka hina orthostatic,
• glucocorticosteroids (GCS), nā lāʻau adrenocorticotropic (ACTH): nui ka nalowale o nā electrolytes, ʻoi aku ka potassium
• digoxin: hoʻonui hoʻonui i ka hoʻonaninani o ka digoxin (me ka nui o ka haunaele i hōʻoki ʻia),
• nā lāʻau lapaʻau hypoglycemic: ka ulu ʻana o ka hyperglycemia, hoʻonui i ka hoʻohaʻahaʻa glucose.
• nā mea kanu vasoconstrictor: kahi hōʻemi i ko lākou hopena,
• tetracycline a me nā lāʻau lapaʻau e pili ana i ka magnesium: hoʻemi iki ʻia o kā lākou mea ikaika,
• Lithium-noho lāʻau lapaʻau: hoʻēmi iʻa ka pale ʻana i ka lithium, hoʻonui nui aʻe o ka hoʻomohala ʻana i nā hopena ʻino, piʻi nui ka maʻi o ka lithium
• nā mea kanu antihypertensive: hoʻonui i kā lākou hana, ʻoi aku ka beta-blockers a me nā ganglion blockers,
• ole-antiidal anti-inflammatory raau (NSAIDs): nā nāwaliwali o ka hypotensive, diuretic, kahi hana natriuretic o Accuzide, hana hana ʻole a ka hopena i loko o nā poʻe maʻi maʻi, a me ka hōʻemi ʻana i ka BCC a me nā hana ʻole.
• nā lāʻau lapaʻau e hoʻonui ai i ke kiʻekiʻe o ka pāhana ma ke koko: he hoʻonui nui aʻe o ka hoʻomohala ʻana i ka hyperkalemia,
• resins pākana: hoʻopukapuka hoʻopukapuka o hydrochlorothiazide,
• nā hana anti-gout: ke kīnā ʻole o nā kūlana o nā mea maʻi me ka gout, ka hoʻonui nui aʻe o ka hopena o ka maʻi hypersensitivity i nā huahana anti-gout,
• hua lāʻau ncotic, analcc narcotic, lāʻau lapaʻau no ka hoʻohaʻahaʻa i ke koko koko: hoʻonui hua hypotensive o Accuzide,
• immunosuppressants, cytostatics, allopurinol, procainamide: nui loli hoʻonui o ka leukopenia,
• glycosides cardiac a me nā lāʻau lapaʻau ʻē aʻe hiki ke alakaʻi i ka hoʻomohala ʻana o nā arrhythmias type pirouette: hoʻonui i ka nui o ka hypokalemia, hoʻonui i nā hopena o nā mea make,
• aliskiren: ka hopena o ka pālua i ka hana RAAS, i hōʻike ʻia e ke kahe ʻana o ke koko, hoʻololi i ka hana o ka maʻi, hyperkalemia,
• ʻO mTOR a me DPP-4 mau inhibitor: hoʻonui nui aʻe o ka hoʻomohala ʻana i ka edema Quincke.