Gensulin N (Gensulin N)

Ka helu ʻai ʻana o ka hele ʻana o Gensulin N - ka hoʻōki ʻana i ka hoʻoponopono subcutaneous (s / c): kahi hoʻopiʻi keʻokeʻo, ka ʻōpū e hoʻokaʻawale ai i kahi keʻokeʻo keʻokeʻo e hoʻomaha ana me ka palahalaha ʻole a i ʻole nā ​​waihoʻoluʻu ʻē aʻe, me ka pulu mālie, wikiwiki koke ka hoʻopihapiha ʻia. mau ʻōpala kūmole o nā pahu he 5, 1 pākīpī i loko o ka pūlima pepa, 10 ml kēlā me kēia i nā wai i loko o ke aniani o ka aniani paʻi ʻole, 1 pahu i loko o kahi pūlani pepa.

Ka Hoʻohui i ka 1 ml o ke kauā.

• mea waiwai: insulin-isophan recombinant kanaka - 100 IU,
• Nā mea kōkua: phenol, glycerol, metacresol, protamine sulfate, sodium hydrogen phosphate dodecahydrate, zinc oxide, hydrochloric acid, ka wai no ka injection.

Nā hōʻailona no ka hoʻohana ʻana

Hāʻawi ʻia ʻo Gensulin N no ka hoʻohana ʻana i ka mellitus type 1 i ka wai, a me ka maʻi mellitus type type 2 i ke kū ʻana o ka lawehala a me nā lawaiʻa hypoglycemic no ka hoʻohana waha, i ka pale ʻana i ka pale ʻana i kēia mau lāʻau (ma ka hihia o ka hopena hui pū ʻia) a me nā maʻi intercurrent.

ʻLoe a me ke kākele

Hoʻoholo ʻia ka ʻaina ʻo Gensulin N no ka hoʻokele sc.

Hoʻoholo ke kauka i ka hopena o ka lāʻau lapaʻau i kēlā me kēia hihia i kau ʻia e nā kuhikuhi o ke kaila o ke koko, a nānā i nā ʻano o ka mea maʻi. Ka loli iki ka laʻana o kēlā me kēia lā ma waena o ka 0.5-1 IU i ka 1 kg o ka paona maʻi.

ʻOi aku ka hoʻonāukiuki ʻia ma ka ʻāʻī, ua ʻike ʻia hoʻi e hoʻopuka i ka lāʻau lapaʻau i loko o ke ʻeke, ʻo ka pā mua o ka ʻūhā a i ʻole ke kelepona o ka ʻūhā. Pono e hoʻololi ʻia nā pūnaewele injection i loko o ke aniani anatomical i mea e pale aku ai i ka lipodystrophy.

Ke koi nei i ka pohi ʻana, pono ʻole e lulu nui ka kīʻaha a i ʻole ka pahu kaʻa, no ka mea, e hoʻokūpaʻa ʻia paha ka pahuhū, e paʻakikī ana i ka hoʻonohonoho pono ʻana i ka pona. Pono pono ke nānā ʻia o ke ʻano o ka lāʻau i loko o nā kīʻaha a me nā pahu kūlohelohe inā loaʻa nā flakes i ka hoʻokuʻu a a i ʻole nā ​​mea keʻokeʻo e nānā ʻia ana e pili ana i ka lalo / paia o ke kīwī a i ʻole ka pahu kime, e hana ana i ka hopena o ka hau, ʻaʻole pono e hoʻohana.

Pono i ka mahana o ka pohō i hoʻopaʻa ʻia e pili ana i ka mahana o ka lumi.

1. Hoʻopōʻeha i ka ʻili me ka waiʻona ma ka pūnaewele injection.
2. E hoʻohana i nā manamana lima ʻelua e hoʻopili ai i ka ʻili.
3. Hoʻokomo i ka pūpū ma ke kihi o 45 ° i loko o ke kumu o ke paʻi a hoʻoiho i ka insulin ma lalo o ka ʻili.
4. Ma hope o kahi hōʻki ʻana ma ka liʻiliʻi o 6 kekona, mai kāpae i ka pono e hōʻoia e hoʻokele pono ʻia nā lāʻau.
5. Inā hele mai ke koko ma ka wahi hoʻokipa ma hope o ka hemo ʻana o ka pūkaʻi, kī liʻiliʻi me ia me kou manamana lima.
6. Pono e hoʻololi ʻia nā pūnaewele injection.

Hoʻohana ʻia ʻo Gensulin N ma ke ʻano lāʻau lapaʻau monotherapy a ma o ke ʻano o ka mālama paʻakikī me ka insulin-short acting (Gensulin P).

Pono nā mea maʻi e hoʻomaʻamaʻa me nā ʻenehana no ka hoʻohana ʻana i ka lāʻau lapaʻau, hilinaʻi i nā kūlana i lalo.

ʻO ka hoʻohana ʻana o ke kali ʻana i nā kiʻi

Ke hoʻohana nei i hoʻokahi ʻano insulin:

1. Hoʻokuʻu i ka pale pale pale mai ka pahu pale.
2. Hoʻonohonoho maikaʻi i ka membrane kuʻi i ka vial.
3. E hōʻiliʻili i ka ea i loko o ka syringe i ka lahilahi e kūpono ana i ka nui o ka inika o ka insulin a hoʻokomo i ka lewa i loko o ke kīʻaha.
4. Hoʻohuli i ke kīwī me nā syringe i hoʻohui ʻia a hōʻiliʻili i ka nui o ka inika i koi ʻia i ka insulin.
5. Hoʻokuʻu i ka mea pono mai ke kīʻaha, e hoʻoneʻe i ka lewa mai ka ʻili, a hōʻoia i ka dosis pono o ka insulin.
6. Hana i kahi inikua.

ʻO ka hoʻohana ʻana o ʻelua mau ʻano o ka insulin:

1. Wehe i nā pale pale pale alumini mai nā pahu.
2. Hoʻonemono i nā membrane kuʻekuʻe ma nā pahu.
3. Ma mua o ke kāhea ʻana, e ʻohi i kahi kīwī o ka insulin o ka hana lōʻihi (lōʻihi) i ke ʻano o ka pohō ʻana ma waena o nā pālapa a hiki i ka hoʻomāʻō iki ʻia a hūnā ʻia nā keʻena pani keʻokeʻo keʻokeʻo.
4. E hōʻiliʻili i ka ea i loko o ka syringe i ka lahilahi e pono ai i ka inika lōʻihi o ka hana lōʻihi, hoʻomohala i ka ea i loko o ke kīʻaha me ke kali ʻana, a laila hoʻoliu i ka pono.
5. Ninini i ka lewa i loko o ka syringe i loko o ka nui e like me ka nui o ka inika o ka insulin hana pōkole, hoʻomāliʻi i ka ea i loko o ke kīʻaha o ka insulin i ke ʻano o kahi hopena maʻalahi, e hoʻohuli i ke kīwī me ka syringe i kū i lalo a hoʻopiha i ka wai i koi ʻia.
6. Hoʻokuʻu i ka mea pono mai ke kīʻaha, e hoʻoneʻe i ka lewa mai ka ʻili, a hōʻoia i ka dosis pono o ka insulin.
7. Hoʻokomo i ka pūpū i loko o ke kīʻaha me ka pohō ʻana, e hoʻohuli i ke kīwī me ka syringe i lalo a hōʻiliʻili i ka wai nui i koi ʻia o ka insulin hana lōʻihi.
8. Hoʻokuʻu i ka pono mai ke kīʻaha, e hoʻoneʻe i ka lewa mai ka ʻili, a nānā pono inā kūpono ka nui o ka nui o ka insulin.
9. Hana i kahi inikua.

He mea nui e kaomo mau i ka insulin i ka mahele i hōʻike ʻia ma luna.

ʻO ka hoʻohana mauʻana o ke kāpena i ka pahu pahu

Hoʻohana ʻia nā cartridges me ka lāʻau lapaʻau Gensulin N no ka hoʻohana wale ʻana me nā peni syringe o ka ʻoihana ʻo "Owen Mumford". Pono e nānā ʻia nā koi i hāʻawi ʻia i nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i ka peni ʻo ke syringe no ka lawelawe ʻana i ka insulin.

Ma mua o ka hoʻohana ʻana iā Gensulin H, pono e nānā pono ʻia ka pahu kīpiha a me ka ʻike ʻole mai ka make ʻole (nā pahu, nā poho); inā lākou i laila, ʻaʻole hiki ke hoʻohana ʻia ka pahu kaʻa. Ma hope o ka kau ʻana i ka pahu pahu i ka penehina syringe, pono ke ʻike ʻia kahi ʻāpana kala i ka puka makani o ka mea e paʻa ai.

Ma mua o ke kau ʻana i ka pahu kāwili i ka peni mauʻu, pono ia e huli i lalo a i ʻole ka waihona liʻiliʻi liʻiliʻi ma loko o ka hoʻopili ʻana. Hoʻohuli hou ke ʻano huli ʻana i ka hapa he 10 mau manawa, a hiki i kahi neʻe ke keʻokeʻo a ʻokoʻa hoʻi e uhi ʻia ana ke ao. E hana pono i kahi inikua ma hope o kēlā.

Inā hoʻokomo ʻia ka pahu pahu i ka peni ma mua, ke kāwili ʻana i ka hana o ka hoʻopiʻi ʻia e hoʻokō ʻia no ka pūnaehana holoʻokoʻa (ma kahi o 10 mau manawa) a e kau hou ma mua o kēlā me kēia maʻi.

Ma ka hoʻopau ʻana i ka ʻōlelo, pono ke waiho ʻia ka pulupulu ma lalo o ka ʻili no ka liʻiliʻi o 6 mau kekona, a ʻo ka pihi e hoʻomau ʻia e ʻū a hiki ke oki wale ʻia ka pono mai lalo o ka ʻili. E hōʻoia kēia e mālama pololei ʻia ka pākīpī a hoʻopaʻa i ka hiki o ke koko / lymph e hele ana i loko o ka lāʻau a a ʻehā hoʻi.

ʻO ka pahu pahu me ka lāʻau lapaʻau ʻo Gensulin N i manaʻo ʻia no ka hoʻohana hoʻokahi wale nō a ʻaʻole hiki ke ʻoni ʻia.

Nā hopena hopena

• nā hopena o ka hopena i ka hana o ka hoʻoliʻiliʻi o ka hopena: ke ʻano o ka hypoglycemic - ka ʻeha, ka ʻā ʻana o ka ʻili, palpitations, nui ʻana o ka momona, nā haʻalulu, ka huhū, ka pōloli, paresthesia i ka waha, ma muli o ka hypoglycemia koʻikoʻi, hiki ke hoʻomohala i ka hypoglycemic coma.
• nā hopena ʻokoʻa o ka hypersensitivity: lohi - rashes ma ka ʻili, ka edema o Quincke, ʻaʻole loaʻa loa - ka pīhoihoi anaphylactic,
• mau hopena ma ka wahi i hōʻike ʻia: ka huehue a me ka hana haʻalulu, hyperemia, inā ka lōʻihi o ka hoʻohana ʻana - lipodystrophy ma ka wahi i ʻōlelo ʻia.
• Nā mea ʻē aʻe: edema, nā hewa refractive hewa (maʻamau i ka hoʻomaka ʻana o ke ʻano o ka papa lāʻau).

ʻO nā hōʻailona o ka overdose ka hoʻomohala ʻana o ka hypoglycemia. No ka mālamaʻana i nā kūlana haʻahaʻa, ua paipai ʻia i ka ʻai momona a i ʻole nā ​​meaʻai me nā mea momona. ʻO ka maʻi me nā maʻi maʻi e hoʻomau mau i ka kō, ke kīkeke, nā kuki, a me nā mea inu momona.

Ma ka hopena o ka hōʻemi nui o ka neʻe o ka glucose, ma kahi o ka nalowale o ka ʻike ʻana, ʻo kahi 40% dextrose e lawelawe ʻia i ka hana intravenously, e lawelawe ʻia ana ʻo glucagon me ka intramuscularly, intravenously a i ʻole subcutaneously. Ma hope o ka loaʻa hou ʻana i ka ʻike, pono e ʻai i nā meaʻai momona aʻai i ke kumu e pale ai i ka ulu hou ʻana o ka hypoglycemia.

Nā ʻōlelo kikoʻī

Ka pāpā ʻia ʻole ʻo Gensulin N inā ʻaʻole i laka ke keʻokeʻo a pīhoihoi i ka wā e lulu.

Ke lawe nei i ka therapy insulin, pono e hoʻomau mau i ka pae o ka glucose i ke koko. Pono kēlā kiaʻi e like ai, no ka mea, he keu i ka nui o ka insulin, nā kumu kumu o ka hypoglycemia: piʻai ʻana i ka ʻai, ke hoʻololi ʻana i ka lāʻau, ka hōʻola ʻana, ka luaʻi ʻana, hoʻonui ʻia i ke ʻano kino e hōʻemi i ka pono o ka maʻi insulin (renal / liver failed, hypofunction o ka adrenal cortex, glandula thyroid a ole nā ​​pituitary gland), hoʻololi site injection, lāʻau lapaʻau me nā mea lapaʻau ʻē aʻe.

ʻO ka makeʻe hewa a haki paha ma waena o nā inikini insulin, keu i nā mea maʻi me ka maʻi diabetes type 1, hiki iā ia ke hana i ka hyperglycemia. ʻO ka maʻamau, ulu pinepine nā hōʻailona mua o ka hyperglycemia, ma luna o nā hola a i ʻole mau lā. Paʻi maloʻo, makewai, ʻuwelele, luaʻi, hōʻeha, ʻulaʻula a me ka maloʻo ʻana o ka ʻili, pau ka momona, ka momona o ka acetone i ka ea hanu, ʻano nui ka urination. Inā lawe ʻole ʻia ka mālama loiloi, a laila me ka type 1 diabetes mellitus, hiki i ka hyperglycemia ke alakaʻi i ke kūkulu ʻana i kahi kūlana e ola nei - ketoacidosis diabetes.

ʻO ke hoʻoponopono ʻana i ka nui o ka insulin e pono ai no ka hypopituitarism, ka holo ʻana o ke aila thyroid, ka maʻi a Addison, ka pāpū a me ka maʻi ole, a me nā mea maʻi ma waena o ka makahiki o 65 mau makahiki.

Pono pono ke hoʻoponopono ʻia o ka insulin i ka hoʻonui ʻia ʻana o ka hoʻoulu ʻana i ka hana kino a i ke hoʻololi ʻana i ka ʻai maʻamau.

Hoʻonui ʻia ka pono o ka insulin e nā maʻi concomitant, aemaise o kahi ʻano maʻi, a me nā kūlana i hele pū ʻia e ke kuni.

ʻO ka hele ʻana mai kahi ʻāpana o ka insulin i kekahi, pono nō hoʻi e hana ʻia, e kāohi ana i ke kiʻekiʻe o ka glucose i loko o ke koko.

He mea nui ia e noʻonoʻo e hoʻohana ʻia ka hoʻohana ʻana o ka insulin i ka hoʻomanawanui ʻana o ka mea maʻi i ka waiʻona.

ʻAʻole hoʻohana ʻia ka hoʻohana ʻana o Gensulin N i loko o ka paukena insulin ma muli o ka hiki o ka ua o ka pohi i kekahi mau catheters.

Hiki i ke hypoglycemia ke hōʻeha i ka mea maʻi e hiki ai ke hoʻokaʻawale a hōʻemi i ka wikiwiki o ka hopena psychophysical, e hoʻonui paha i ka hopena i ka wā o ka lawe ʻana i nā kaʻa a me / a i ʻole e hana me nā mīkini paʻakikī.

Hoʻohui nūhou

• Persiapan hypoglycemic for administrasi oral, monoamine oxidase inhibitors (MAOs), angiotensin konvertere enzim (ACEs), non-selektif β-blockers, carbonic anhydrase inhibitors, bromocriptine, sulfonamides, tetracyclines, octabolofenolofenolides, metabolofolindofloids, mebol, lithium mākaukau, fenfluramine, hoʻomākaukau hoʻomākaukau ʻana e ka hua ʻana: e hoʻoikaika i ka hopena hypoglycemic o ka insulin,
• diuretics thiazide, glucocorticosteroids (GCS), oral contraceptives, thyroid hormones, sympathomimetics, heparin, tricyclic antidepressants, clonidine, danazole, diazoxide, calcium channel blockers, phenytoin, morphine, nicotine: Weaken hypoglycemic effect
• ka hopena a me ka salicylate: hiki iā lāua ke nāwaliwali a hoʻonui i ka hana o ka insulin.

ʻO nā analogues o Gensulin N i: Biosulin N, Vozulim N, Insuman Bazal GT, Insuran NPH, Nā Protamine-insulin hōʻeha, Protafan NM, Protafan NM Penfill, Rinsulin NPH, Rosinsulin S, Humodar B 100 Rec.

Hoʻohui Kūʻai Kūʻai

Hoʻokuʻu ʻia e ka papa lāʻau.

Hōʻike nui ʻia ka ʻike e pili ana i ka lāʻau lapaʻau, i hoʻolako ʻia no ka hana ʻike a ʻaʻole hoʻololi i nā ʻōlelo aʻoaʻo. Hoʻopilikia ka lāʻau-pono iā ia ke olakino!

Meliila a keu ka hānau ʻana, ola a make a puna i kā mākou puna. Hiki ke ʻike ʻia lākou ma ka hoʻonui ʻana nui, akā inā i hui pū ʻia, e kūpono lākou i loko o kahi kīʻaha kīkaha maʻamau.

Aia nā mea lapaʻau maʻi keu nui loa, e like me ka nānā ʻana o nā mea nānā. Ma ka ʻōpū o kahi mea hoʻomanawanui e loaʻa ana i kēia mania, ua loaʻa nā mea 2500 mau mea ʻē.

ʻAʻole loaʻa nā manamana lima pilikino wale nō, akā he ʻōlelo nō hoʻi.

I mea e haʻi aku ai i nā ʻōlelo pōkole loa a hoʻohana maʻalahi.

Ma UK, aia kekahi kānāwai e like me ka mea e hiki ai i ka mea maʻi ke hōʻole e hana i ka hana ma ka mea maʻi inā ulaula a i ke kaupaona ʻana. Pono ke kanaka e haʻalele i nā hana ʻino, a laila, ʻaʻole paha, ʻaʻole pono ia e kāpili ʻia.

ʻO ka lāʻau lapaʻau ʻo "Terpincode" kekahi o nā alakaʻi i ke kūʻai ʻana, ʻaʻole naʻe ma muli o kāna mau lāʻau lapaʻau.

Ua ʻike hou ʻia nā Dentist. I ka hope o ke kenekulia 19, ua hana ia i kahi mea kāhiko maʻamau e huki i nā niho maʻi.

Ua hoʻopaʻa ʻia ke kiʻekiʻe wela o ke kino ma Willie Jones (USA), i hōʻike ʻia i ka haukapila me ke ʻano 46.5 ° C.

Inā oki ka hana o kou ate, e make ka make i loko o ka lā.

ʻO ka lāʻau lapaʻau maikaʻi loa "Viagra" i hana mua ʻia no ka mālama ʻana i ka hypertension arterial.

ʻO ka maʻi ʻemi loa ka maʻi o Kuru. Ua maʻi wale nō nā lālā o ka ʻohana Fore ma New Guinea. Make ka mea maʻi. Ua manaʻoʻiʻo ia ke kumu o ka maʻi i ʻai ai i ka lolo o ke kanaka.

Ua hana ka poʻe ʻepekemaʻAmelika i nā hoʻokolohua ma ka mau kiole a hiki i ka hopena i pale ʻia i ka wai kime i ka hoʻomohala ʻana o ka atherosclerosis o nā kīʻaha koko. Hoʻokahi kekahi pūʻulu o nā kiʻi i ka wai anuanu, a ʻo ka lua o ka wai wai kinawai. ʻO ka hopena, ua kaʻawale nā ​​ipu o ka hui lua i nā kolika poli o ka kolamu.

Me ka kipa pinepine ʻana i ka moena maka, hiki i ka manawa o ka loaʻa ʻana o ka maʻi maʻi kino e hoʻonui ʻia e 60%.

Ke "holo" nei ke koko o ke kanaka ma o nā moku ma lalo o ka pīhoihoi nui a, inā e hoʻokaʻawale ʻia kona kūpaʻa, hiki ke pana i ka 10 mau mika.

Hiki i kā mākou mau lolo ke hoʻomaʻemaʻe i ʻekolu liters o ke koko i hoʻokahi mau minuke.

ʻO ka hapa ʻole o nā niho a i ʻole hoʻopau paha i ka adentia hiki i ka hopena o nā hōʻeha, nā caries a i ʻole nā ​​maʻiʻeha. Eia naʻe, hiki ke hoʻololi ʻia nā niho nalo i nā niho.

Nosological ʻano papa (ICD-10)

Lapaʻau lāʻau

ʻO Gensulin H - i loaʻa i ka insulin kanaka me ka ʻenehana DNA recombinant. ʻO ia kahi hoʻomākaukau hana hana medium-hana. Hoʻōlili aku me kahi receptor kūikawā ma ka membone cytoplasmic o waho o nā pona a hana i kahi mea i ʻike ʻia e ka insulin i mea e hoʻoulu ai i nā hanana intracellular, ʻo ia hoʻi ka synthesis o kekahi o nā kīʻaha koʻikoʻi (me ka hexokinase, pyruvate kinase, glycogen synthetase). ʻO ka emi ʻana o ke kō o ka koko ma muli o ke komo ka hoʻonui ʻana i kāna huakaʻi intracellular, hoʻonui i ka uptake kiko a me ka assimilation, hoʻoulu i ka lipogenesis, glycogenogenesis, a me ka hoʻohaʻahaʻa i ka helu o ka hana glucose i ka ʻāʻī.

ʻO ka lōʻihi o ka hana o ka hoʻomākaukau ʻana o ka insulin no ka nui o ka absorption, ka mea e hilinai ana i nā mea he nui (no ka laʻana, ka hoʻohālikelike, ke ʻano a me nā wahi o ka hoʻokele), a no laila ua pili ʻia ka ʻike o ka insulin e pili ana i nā loli nui, i nā kānaka like ʻole a me ka mea like i ka mea like . ^ E Ha yM.

ʻĀlelo hana me ka wanana (sc i kahi helu): ka hoʻomaka ʻana o ka hana ma hope o ka hola 1,5, ka hopena nui loa ma ka waena ma waena o 3 a 10 mau hola, ʻoi aku ka lōʻihi o ka hana a 24 mau hola.

Lapaʻau lāʻau

ʻO ka hoʻopau piha ʻana o ka pā a me ka hoʻomaka ʻana o ka hopena o ka insulin e hilinaʻi mai ka pūnaewele inikua (ʻōpū, ʻūhā, nā maka), ke kūwaho (ka nui o ka inikua i paʻi ʻia), ka ʻike ʻana o ka insulin i ka lāʻau lapaʻau. Hoʻowalewale ʻia ʻole ia ma waena o nā kiko: ʻaʻole ia e komo i ka pili plasenta a i loko o ka waiū umauma. He luku ʻia ia e ka insulinase, ka nui ma ka ate a me nā lolo. Hoʻokuʻu ʻia ia e nā keiki (30-80%).

Hoʻohui

Hypoglycemic hopena o ka insulina ka hōʻoi 'ku una ha hypoglycemic ai', Mao nā mea kūpale, ACE nā mea kūpale, carbonic anhydrase nā mea kūpale, ole-e wae β-blockers, bromocriptine, octreotide, sulfonamides, anabolic steroid, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, likiuma hoomakaukau hoʻomākaukau e pili ana ka ethanol.

Contraceptives oral, corticosteroids, thyroid hormone, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazole, clonidine, BKK, diazoxide, morphine, phenytoin, nicotine nawaliwali i ka hopena hypoglycemic o ka insulin.

Ma lalo o ke kiʻi o ka reserpine a me salicylates, hiki ke nawaliwali a me ke hoʻonui ʻana i ka hana o ka lāʻau lapaʻau.

ʻLoe a me ke kākele

S / c i ka ʻāʻī. Hiki ke loaʻa nā ʻōkuhi i ka paia o ka ʻōpū o ka ʻōpū, ka puhipuhi, a i ʻole ka hopena o ka uaua deltoid o ka poʻohiwi.

Pono e hoʻololi i ka pae injection i loko o ka wahi o anatomical i mea e pale ai i ka hoʻomohala ʻana o ka lipodystrophy.

Kuhi ʻia ka hopena o ka lāʻau e ka kauka ponoʻī i kēlā me kēia hihia, e pili ana i ka pae o ka glucose i ke koko. I ka awelika, ka laʻana o kēlā me kēia lā o ka lāʻau mai ka 0.5 a i 1 IU / kg (e like me nā ʻano o ka mea maʻi a me ka pae o ka glucose i loko o ke koko).

Pono ka wela o ka insulin i ka mahana ma waena o ka lumi.

Hiki ke lawelawe ʻia ka Gensulin N a i ʻole ke hui pū ʻana me ka insulin hana pōkole (Gensulin P).

Ke keu

Nā Hoʻomaka Hoʻokumu paha ka hypoglycemia.

Lāʻau: hiki i ka mea maʻi ke hōʻoki i ka hypoglycemia palu ma ka lawe ʻana i ke kōpaʻa aʻai ʻole nā ​​mea ʻai i ka haʻalulu. No laila, ua makemake ʻia no nā maʻi me ka maʻi diabetes e lawe i ka kō, ke kīkeke, nā kuki a me nā wai momona maikaʻi me lākou.

Ma nā pilikia koʻikoʻi, i ka wā e nalowale ai ka mea maʻi, ʻike ka hopena o 40 dextrose e ka iv, i / m, s / c, iv glucagon. Ma hope o ka loaʻa hou ʻana i ka ʻike, ʻike ʻia ka mea maʻi e ʻai i nā meaʻai momona a keu e pale ai i ka hoʻomohala ʻana o ka hypoglycemia.

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana a me ka pōpoki

Nā mea hoʻoweliweli: m-cresol - 1,5, phenol - 0.65 mg, glycerol - 16 mg, protamine sulfate - 0.27 mg, zinc oxide - 30 μg, disodium hydrogen phosphate dodecahydrate - 5.04 mg, hydrochloric acid 0.1M - 0.03 ml.

3 ml - nā pahu kāwili i nā penikala syringe (5) - blisters (1) - mau pahu pahu.
10 ml - mau pahu (1) - mau pahu pahu.

Ka hana lāʻau lapaʻau

ʻO ka insulin DNA recombinant kanaka. ʻO ia kahi insulin o kahi lōʻihi lōʻihi o ka hana. Kāohi i ka metabolism glucose, loaʻa nā hopena anabolic. I ka naʻau a me nā kikoo ʻē aʻe (me ka ʻokoʻa o ka lolo) e hoʻoneʻe ana ka insulin i ka halihali intracellular o ka glucose a me nā waikawa amino, a hoʻonui i ka anabolism protein. Hoʻokomo ʻo Insulin i ka hoʻololi ʻana o ka glucose i ka glycogen i loko o ka ate, ka pale ʻana i ka glucoseoneogenesis a hoʻoulu i ka hoʻololi ʻana o ka nui o ka glucose i ka momona.

ʻAka lāʻau

ʻO ka insulin hana hoʻopaʻa. Hoʻēmi i ka hoʻoliʻi o ka glucose i loko o ke koko, hoʻonui i kona kōpuhi e nā kiko, hoʻomaikaʻi i ka lipogenesis a me ka glycogenogenesis, ka hoʻāla ʻana o ka protein, e hoʻemi ana i ka huina o ka hana glucose i ka ate. Hoʻopili ʻo ia me kahi kākākia kūikawā ma nā membrane waho o nā pona a hana i kahi mea hoʻonaninani o ka insulin. ʻO ka hoʻohaʻahaʻa o ka glucose koko ka mea i hoʻonui ʻia i loko o kāna kaomi intracellular, hoʻonui i ke kūoʻi ʻana a me ka assimilation o nā kiko, hoʻoulu ʻana i ka lipogenesis, glycogenogenesis, protein synthesis, hoʻemi i ka helu o ka hana glucose i ka ate (hōʻemi i ka wā hoʻomaha glycogen), a me nā mea hou aku i ka hōʻemi ʻana i ka subcutaneous, hopena i loko o 1-2 mau hola. aia ka hopena ma waena o nā hola 2-12, ʻo ka lōʻihi o ka hana -18-24 mau hola, hilinaʻi i ka mea hoʻokumu o ka insulin a me ka makeke, e hōʻike ana i nā hōʻike koʻikoʻi inter- a me intra-pilikino. Ka puʻu ʻana a me ka hoʻomaka ʻana o ka hana ma ka ala o ke kaʻi ʻana (sc a intramuscularly), kahi (ʻōpū, ʻūhā, puhaka) a me ka nui o nā maʻi i ka lōkō, kūlia ka insulin i ka lāʻau lapaʻau, a me nā mea i hoʻoili ʻia i loko o ka palaka, ʻaʻole ia e komo i ka paʻa plenta a i loko o ka umauma. waiū. He luku ʻia ia e ka insulinase, ka nui ma ka ate a me nā lolo. Ke hoʻopio ʻia nei e nā ʻōpū.

Ke hoʻohana nei i ka lāʻau

ʻO ka maʻi mellitus type type 1. Nā mākia 2. Mellitus, ka pale ʻana i ka lāʻau hypoglycemic oral, ka pale ʻana i ka pale ʻana i ka lāʻau hypoglycemic oral (hui pūnaʻi), nā maʻi kūlohelohe, nā hana hoʻihoʻi (mono- a i ʻole ka hui pū ʻana), ka maʻi mellitus i ka wā hāpai. )

Nā hopena like ʻole

Allergic reaction (urticaria, angioedema - fever, shortness o ke ea, ka hoʻokahe ʻana o ke koko), hypoglycemia (pallor o ka ʻili, hoʻonui nui ʻia, luhiluhi, palpitations, haʻalulu, pōloli, hoʻomālikelike, hopohopo, paresthesia i loko o ka waha, ʻeha, ka hiamoe, moe hopohopo, hopohopo kaumaha, huhū, kūlohelohe ʻokoʻa, hewa ʻole o ka hoʻoweliweli, ʻōlelo a me ka hōʻino ʻia), hypoglycemic coma, hyperglycemia a me ka maʻi diabetes (ma nā helu haʻahaʻa, hoʻokaʻae i nā inikua, hiki ʻole ke hele i ka ʻai, ka ʻū a me nā maʻi): ke hiamoe, makewai, hoʻohaʻahaʻa i ka makemake, ʻāhaʻi ʻana o ka maka), ka ʻike naʻau (a hiki i ke kūkulu ʻana i kahi kohu a me ka coma), nā hana hoʻolilo i ka ʻike (ʻo ka manawa ma ka hoʻomaka ʻana i ka hopena), ka huakaʻi maʻi immunological me ka insulin kanaka, hoʻonui nui i nā anti-insulin antibodies me nā piʻi aʻe o ka glycemia, hyperemia, hoʻonāukiuki a me ka lipodystrophy (atrophy a i ʻole hypertrophy o ka momona subcutaneous) ma ka pae hoʻokō. I ka hoʻomaka ʻana o ka hoʻōla, ka lō a me ke ʻano hōʻino (ʻo ia ka pōkole a nalo me ka mālama mau ʻana).

Hoʻopuka

Kūleʻa ʻole ka laila me ka hoʻonā o nā lāʻau ʻē aʻe. Hoʻonui ʻia ka hopena hypoglycemic e nā sulfonamides (me nā huaʻōlelo hypoglycemic waha, sulfonamides), ʻae ʻo MAO (me ka furazolidone, procarbazine, selegiline), nā mākaʻi anhydrase carbonic, nā mea paʻa o ACE, nā lāʻau anti-inflammatory anti-inflammatory (me ka pū kekahi). anabolic anabids (me ka stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, Li + hoʻomākaukau, pyridoxine, quinidine quinine, quinine Ua palupalu ka hopena hypoglycemic e ka glucagon, somatropin, glucocorticosteroids, contraceptives oral, estrogens, thiazide a me diuretics loop, BMCC, hormon tiroid, heparin, sulfin pyrazone, sympathomimetics, danazole, tricyclic antidepressants, calcinone, diacidone, polio, antioksidone, polio, antioksidone, polyacone, polyacone, antioksidone, polio epinephrine, blockers o H1-histamine receptors. Nā beta-blockers, reserpine, octreotide, pentamidine hiki i ka mea hou ke hoʻomaikaʻi a hoʻonāwaliwali i ka hopena hypoglycemic o ka insulin.

Nā ʻāpana a me ke ʻano o ka noi

ʻO Subcutaneously, 1-2 mau manawa i ka lā, 30-45 mau minuke ma mua o ka ʻaina kakahiaka (hoʻololi i ke kahua injection i kēlā me kēia manawa). I nā hihia kūikawā, hiki i ke kauka ke kuhikuhi i kahi kuhi intramuscular o ka lāʻau. Hoʻokomo ʻia ka ʻae ʻana o ka insulin o ka lōʻihi o ka wā! Kahi ʻia nā ʻōpona holoʻokoʻa a hilinaʻi ʻia i ka ʻike o ka glucose i ke koko a me ka urine, nā ʻano o ke ala o ka maʻi. ʻO ka maʻamau, ʻo nā helu he 8-24 ME 1 ka manawa i kēlā me kēia lā. I nā mākua a me nā keiki me ka manaʻo kiʻekiʻe o ka insulin, kahi haʻahaʻa o lalo mai o 8 IU / lā e lawa paha, i nā mea maʻi me ka hoʻohaʻahaʻa iki - ʻoi aku ma mua o 24 IU / lā. I kahi lā maʻamau i kēlā me kēia lā he 0.6 IU / kg, - ma ke ʻano o 2 injections ma nā wahi like ʻole. ʻO ka poʻe maʻi e loaʻa ana i ka 100 ME a i ʻole i kēlā me kēia lā, ke hoʻohuli nei i ka insulin, pono ke kipa ʻia i ka haukapila. Pono e hoʻoili ʻia mai kekahi lāʻau lapaʻau ʻē aʻe ma lalo o ka kaohi o ka glucose koko.

E hoʻokuʻu i ke ʻano, ka pūpū a me ka hoʻopili ʻana ʻo Gensulin N

Hoʻomoe ʻia no ka s / c hoʻokele o ke keʻokeʻo keʻokeʻo, ke kū ana, kahi pihi keʻokeʻo a ʻokoʻa ʻole a i ʻole ʻae a palahalaha ʻole ʻia ka puana ʻia, maʻalahi ke ʻano o ka pulu ʻia me ka pulu ʻoluʻolu.

Nā mea kūʻai: metacresol - 1,5 mg, phenol - 0.65 mg, glycerol - 16 mg, protamine sulfate - 0.27 mg, zinc oxide - a hiki i 40 Zg Zn 2+ / 100 ME, sodium hydrogen phosphate dodecahydrate - 5.04 mg, hydrochloric acid - q.s. a i o pH 7.0-7.6, wai d / i - hiki i ka 1 ml.

3 ml - mau kāleka (5) - pale polū.
10 ml - mau hue (1) - nā pākiha o nā kāleka.

Nā hōʻike mai ka lāʻau Gensulin N

• maʻi diabetes type 1
• type 2 diabetes mellitus: ka pae kūʻē o ke kūmole hypoglycemic waha, ka pale kūpaʻa ʻana i kēia mau lāʻau (i ka wā hui pū ʻana), nā maʻi ʻeha.

Ka hoʻoponopono ʻia ʻana

Kuhi ʻia ʻo Gensulin N no ka hoʻokele sc. Kuhi ʻia ka hopena o ka lāʻau e ka kauka ponoʻī i kēlā me kēia hihia, e pili ana i ka pae o ka glucose i ke koko. I ka awelika, ka Lapa o kēlā me kēia lā o ka lāʻau lapaʻau mai ka 0.5 a i ka 1 IU / kg kaupaona kino (ma muli o nā hiʻohiʻona pilikino o ka mea maʻi a me ka pae o ka glucose o ke koko).

Pono ka wela o ka insulin i ka mahana ma waena o ka lumi.

Hoʻohālikelike ʻia ʻo Gensulin H ma ka ʻūhā. Hiki ke loaʻa nā ʻōkuhi i ka paia o ka ʻōpū o ka ʻōpū, ka puhipuhi, a i ʻole ka hopena o ka uaua deltoid o ka poʻohiwi.

Pono e hoʻololi i ka pae injection i loko o ka wahi o anatomical i mea e pale ai i ka hoʻomohala ʻana o ka lipodystrophy.

Hiki ke loaʻa iā Gensulin N me ke kūʻokoʻa a hui pū me ka insulin hana pōkole (Gensulin P).

E hāʻawi ʻia nā ʻōkuhi i ka mea maʻi

Hoʻololi ia i ka inikini no ka wīwī

Inā hoʻohana ka mea maʻi i kahi ʻano like ʻole o ka insulin

1. Hoʻopilikia i nā kūpeʻe palupalu ma ke kīʻaha.

2. ninini i ka ea i loko o ka syringe i ka nui e kūpono i ka inika e makemake ʻia ana o ka insulin. E hoʻolaha i ka ea i loko o ke kīʻaha o ka insulin.

3. E hoʻohuli i ke kīʻaha me ka ʻili re ʻole e kahakaha i lalo a hoʻoneʻe i ka inika makemake ʻia o ka insulin i loko o ka ʻili. Hoʻokuʻu i ka pūpū mai ke kīʻaha a hoʻohemo i ka ea mai ke syringe. E nānā inā pololei paha ke ʻano o ka insulin.

4. E hoʻoili koke.

Inā pono ka mea maʻi e hoʻohui i ʻelua mau ʻano o ka insulin

1. E pale i nā membrane huila ma nā pahu.

2. Ma mua o ke kāhea ʻana, e ʻoloka i kahi hue o ka lōʻihi o ka hana o ka insulin ("cloudy") ma waena o kou mau palemene a hiki i ka insulin ke keʻokeʻo a keʻokeʻo.

3. ninini i ka lewa i loko o ka syringe i loko o kahi nui e like me ka nui o ka nui o ka insulin awan. Hoʻokomo i ka ea i loko o ke kīkala hoʻonani wela a hoʻoneʻe i ka pono mai ka vial.

4. E huki i ka lewa i loko o ka syringe i loko o kahi nui e like me ke kaomi o ka inanā hana pōkole (“transparent”). Hoʻomaopopo i ka lewa i loko o kahi pahu o ka insulin māmā. E hoʻohuli i ke kīʻaha me ka ʻili re ʻole e kū i lalo a kāhea i ke ʻano kiʻekiʻe o ka wina i ʻike ʻia i ka insulin. Lawe i ka huʻu a wehe i ka lewa mai ke syringe. E nānā i ka maʻa pololei.

5. E hoʻokomo i ka pūpū i loko o ke kīʻaha me ka insulin “cloud”, e hoʻohuli i ka vial me ka syringe e kū pono i lalo a kāhea i ke ʻano o ka insulin i makemake ʻia. E hoʻoneʻe i ka lewa mai ka ʻāʻā pūnao a nānā inā he pololei ka pā ʻana. E hoʻokiʻoli koke koke i ka hoʻohuihui o ka insulin.

6. E hoʻokaʻawale i nā insulin i ka papa like e like me ka mea i hōʻike ʻia ma luna nei.

He ʻikepili hana kōmū

Ke koho nei i ka pahu pahu lāʻau me ka lāʻau lapaʻau ʻo Gensulin N no ka hoʻohana wale ʻana me nā peni syringe mai iā Owen Mumford (Nui Pelekane). Pono e hōʻike ʻia ka mea maʻi e pili ana i ka pono e mālama pono i nā ʻōlelo i nā ʻōlelo aʻo no ka hoʻohana ʻana i ka penikala ʻiwīwī no ka lawelawe ʻana i ka insulin.

Ma mua o ka hoʻohana ʻana, e hōʻoia ʻaʻole he mea ʻole o ka pōʻino (no ka laʻana, nā kiʻaka) ma ka pahu pahu me ka hoʻomākaukau ʻana o Gensulin N. Mai hoʻohana i ka pahu pahu inā aia kekahi mau meaʻino. Ma hope o ke kau ʻana i ka pahu kāwili i ka penikala ʻiwikā, e ʻike pono ʻia kahi ʻāpana kala ma ka puka makani o ka mea e paʻa ai ka pahu.

Ma mua o ke kau ʻana i ka pahu pahu i ka peni mauʻu, huli i ka pahu i luna a i lalo i ka neʻe ʻana o ka pahu aniani mai ka hopena a hiki i ka hope o ka pahu pahu. Pono e hana hou i kēia kaʻina hana ma kahi o 10 mau manawa a hiki i ke keʻokeʻo a pau ke keʻokeʻo a ʻoluʻolu hoʻi i ke ʻano. Ma hope koke o kēia mea, pono ke kaha kiʻi.

Inā loaʻa ka pahu pahu i loko o ka peni syringe, pono ʻoe e huli me ka pahu pahu i loko a i lalo i lalo o 10 mau manawa. Pono e hana hou ʻia kēia ʻano ma mua o kēlā me kēia maʻi hou.

Ma hope o ke kahili ʻana, pono e noho pono ka lāʻau ma lalo o ka ʻili no ka liʻiliʻi o 6 kekona. Mālama i ka pihi a hiki i ka nalo ponoi ke hoʻoneʻe ʻia mai lalo o ka ʻili, no laila e hōʻoiaʻiʻo ana i ka hoʻokele ʻona kūpono a me ka hiki ke koko a lymph paha i loko o ka pūkaa a i ʻole ka palena o ka ʻakaʻaka.

Hoʻohana ʻia ka pahu kolohe me ka lāʻau lapaʻau ʻo Gensulin N no ka hoʻohana pilikino wale nō a ʻaʻole pono e hoʻōla ʻia.

1. Me nā manamana lima ʻelua, hopu i kahi ʻili o ka ʻili, e hoʻokomo i ka pūpū me ke kumu o ka pā i ka kihi e pili ana iā 45 °, a hoʻokomo i ka insulin ma lalo o ka ʻili.

2. Ma hope o ke kōpaʻa ʻana, pono e noho ka pono ma lalo o ka ʻili no ka liʻiliʻi o 6 kekona, i mea e hōʻoia ai ua hoʻopili piha ʻia ka insulin.

3. Inā ʻike ʻia ke koko ma ka wahi o ka injection ma hope o ka huki ʻana i ka pūkaʻi, e kaomi malū i ka wahi i ʻōlelo ʻia me kou manamana lima.

4. Pono e hoʻololi i ka pūnaewele injection.

Loaʻa ka hopena

Ma muli o ka hopena i ka metabolism, ʻo ka hypoglycemic kūlana (pallor o ka ʻili, nui ka luhiluhi, palpitations, haʻalulu, pōloli, ʻulepule, paresthesia i loko o ka waha, ʻeha. Hiki i ka hypoglycemia koʻikoʻi ke alakaʻi i ka hoʻomohala ʻana o ka comu hypoglycemic.

He maʻi kūloko: ʻaʻole - palupalu kulit, ka edema Quincke, ʻaʻole loa nā hanana - ka pīhoihoi anaphylactic.

Nā kūloko kūloko: ka hyperemia, ka huapau a me ke kau ʻana i ka wahi i ʻōlelo ʻia, me ka hoʻohana lōʻihi - lipodystrophy ma ka wahi o ka maʻi injectiona.

Nā mea ʻē aʻe: edema, nā hewa refractive hewa (maʻamau i ka hoʻomaka ʻana o ka maʻi).

ʻŌpū a me ka lactation

I ka wā hāpai, ʻoi aku ka nui o ka mālama ʻana i ka mālama glycemic maikaʻi i nā mea maʻi me ka maʻi maʻi. I ka wā hapai, pono ka emi ʻana o ka insulin i ka trimester mua a hoʻonui i ka trimesters lua a me ke kolu.

Manaʻo ʻia e ʻike i nā mea maʻi me ka maʻi mellitus i ke kauka e pili ana i ka hoʻomaka a i ka hoʻolālā ʻana o ka hāpai ʻana.

I nā maʻi me ka diabetes mellitus i ka wā o ka lactation (ka umauma), kahi maʻi e hoʻoponopono ʻia ai ka insulin, ka meaʻai, a i ʻole nā ​​mea ʻelua ke koi.

I nā noiʻi ʻana i nā huakaʻi kino a nā maʻi me ka hopena o ka vitro a me nā hui vivo, ʻaʻohe hana o ka insulin i ka hopena mutagenic.