Vasotens H (Vasotens® H)

ʻO Vazotens N: nā ʻōlelo aʻoaʻo no ka hoʻohana a me nā loiloi

ʻAno Latin: Vasotenz H

Manaʻo ATX: C09DA01

ʻO ka mea kūpono: losartan (Losartan) + hydrochlorothiazide (Hydrochlorothiazide)

Mea Hana: Actavis hf. (Islande), Actavis, Ltd. (Malta)

Hoʻohou i ka wehewehe a me ke kiʻi: 07/11/2019

ʻO nā kumukūʻai i nā lāʻau lapaʻau: mai 375 mau rubles.

ʻO Vazotens N kahi hui antihypertensive hui pū.

E hoʻokuʻu i ke ʻano a me ka ʻano

Ka puka ʻana - nā papa ʻoniʻoni kiʻi: puluniu, biconvex, me nā mea pōpoki hope loa a me nā hōʻeha ma nā ʻaoʻao ʻelua o ka papaʻaina, ma kekahi ʻaoʻao o ka pilikia i ke kau inoa "LH", ma kekahi - "1" (keʻuʻu ʻia 50 mg + 12.5 mg) a i ʻole "2" (dosage 100 mg + 25 mg) (i loko o kahi pā kī he 7, 10 a i ʻole 14 mau p., i loko o ka pahu kīlei o 2 a i ʻole 4 mau blul o nā papa he 7, a i ʻole 1, 3, 9 a he 10 mau pōpole o 10 mau papa, a i ʻole 1 2 kaalō no nā papa he 14 no nā ʻōlelo a no ka hoʻohana ʻana iā Vazotenza N).

Helu 1 papa:

• nā hana ikaika: losartan potassium - 50 a 100 mg, hydrochlorothiazide - 12.5 a i ʻole 25 mg, kēlā
• nā mea waiwai: nā sodium croscarmellose, cellulose microcrystalline, mannitol, magnesium stearate, povidone, White Opadrai (hypromellose 50cP, hypromellose 3cP, titanium dioxide, macrogol, hydroxypropyl cellulose).

Lapaʻau lāʻau

ʻO Vazotens N kahi maʻi hypotensive o ka hui pū ʻana.

ʻO nā waiwai o nā mea ikaika:

• ʻO losartan kahi antagonist e nānā ana i ka angiotensin II (subtype AT1). Hoʻemi i ke kahe o ke koko (BP), ka huakaʻi pale peripheral vascular (OPSS), ke kaomi i ke kaomi pulmonary, ʻono o ka adrenaline a me ka aldosterone i loko o ke koko, e hoʻemi ana i ka hopohopo, he hopena diuretic. I ka poʻe maʻi me ka puʻuwai puʻuwai, e pale i ka hoʻomohala ʻana o ka hypertrophy myocardial a hoʻonui i ka hoʻohaʻomaʻi hoʻōla. ʻAʻole ia e pale i ka kinase II - he enzyme e hoʻopau ai i ka bradykinin,
• ʻO ka hydrochlorothiazide kahi diuretic thiazide. Hoʻemi i ka reabsorption o ka paʻakai sodium, e hoʻomaikaʻi ai i ka hōʻemi ʻana o ka bicarbonate, ka phosphate a me nā pā paʻakai i ka urine.

No laila, ʻo Vazotens N e hoʻemi i ka nui o ke koko kahe, ke hoʻololi nei i ka reaktivita o ka paia vascular, hoʻonui i ka hopena kaumaha ma ka ganglia, e hōʻemi ana i ka hopena pākuʻi o vasoconstrictors, ma laila e hoʻohaʻahaʻa ai i ke koko.

Lapaʻau lāʻau

Ma hope o ka hoʻoponopono waha, ua komo koke ʻo losartan i ka gastrointestinal tract (GIT). Hōʻike ʻia ia e ka bioavailability haʻahaʻa, māhele

33% Loaʻa ia i ka hopena o ka hele mua i ka huni. Hoʻomili ʻia ia e ka carboxylation, ka hopena i ka hoʻokumu ʻana o nā metabolites kūlea a me ka metabolite nui e hoʻoikaika ʻia ai ka maʻi (E-3174). Ma kahi o 99% o ka nui e hoʻopaʻa ʻia ai i nā protein plasma. Ma hope o ka lawe iā Vazotenza N i loko, ke loaʻa ka ʻike nui o ka losartan i loko o 1 hola, ʻo ka metabolite kūlohelohe - mau hola 3-4._½) losartan - 1.5-22 mau hola, E-3174 - 3-4 mau hola.ʻO ka mea: ke kahe ʻana o nā kau - 60% o nā ʻōpū, ʻolipio - 35%.

Ma hope o ka lawelawe waha, ua hoʻokomo koke ʻia ka hydrochlorothiazide i ka pānaʻi ʻana. ʻAʻole i hoʻokaʻawale i ke ake. T_½ - 5.8-14.8 mau hola. Kahi (

61%) i hoʻololi ʻia i ka urine.

Nā Hoʻohui

• maʻi hypotension ikaika,
• pilikia hōʻeha kēkahi QC (hana hoʻopukapuka hana) ≤ 30 ml / min,
• lima hana hoʻopili hewa,
• hypovolemia (me ke kūlike o ke kiʻekiʻe o nā diuretics kiʻekiʻe),
• anuria
• makahiki i 18 makahiki
• hapai a lactation
• hypersensitivity a losartan, hydrochlorothiazide, nā kumulepala sulfonamide a i ʻole nā ​​mea kōkua o ka lāʻau lapaʻau.

Pono e hoʻohana ʻia (Vasotens N me ka akahele):

• nā kuhi ʻana o ke kaulike o ka wai-electrolyte o ke koko (dehydration, hypochloremic alkalosis, hyponatremia, hypokalemia, hypomagnesemia),
• bilateral renal aren stenosis a i ʻole stenosis kahi o hoʻokahi keiki,
• hypercalcemia, hyperuricemia a me / aiʻole gout,
• maʻi mellitus maʻiʻi
• nā maʻi ʻōnaehana o ka io hoonui (me nā systemic lupus erythematosus),
• kaumaha history history
• ʻOiaʻiʻo
• ka hana like ʻana o nā lāʻau anti-inflammatory non-steroidal (NSAIDs), me nā inhibitors COX-2 (cyclooxygenase-2).

Nā hopena hopena

Ke hoʻohana nei iā Vazotenza H, hiki mai paha nā hopena hopena i ka wā e lawe ai i ka potassium losartan a me / a i ʻole hydrochlorothiazide.

Hiki paha nā hopena ʻino:

• mai ka pūnaehana cardiovascular: he mau hōʻailona hōʻemi i ke koko,
• mai ka pānaʻi ʻana mai ka palu: ʻili (1%, ma muli o ka losartan e like me ka ʻāpana o ka lāʻau) - ʻeha, hepatitis,
• ma ka ʻāpana o ka ʻōpū o ka ʻōpū: kūʻai (ma muli o ka hana a losartan),
• nā ʻili a me nā ʻano pāpaʻi: urticaria, angioedema (me ka humuhumu o nā lehelehe, pharynx, larynx a / a ʻōlelo paha) e hiki ke alakaʻi i ka hana o ka ʻōpū o ka ʻōpū, ʻokoʻa loa (ma muli o ka hana a losartan) - vasculitis, komo Maʻi maʻi Shenlein-Genoch,
• Nā ʻalani lōkuhi: jarang - hyperkalemia (serum potassium> 5.5 mmol / l), i hoʻonui ʻia i nā hana o nā ʻalemona.

Me nā hypertension koʻikoʻi, ʻo ka hopena maʻamau ka hopena maʻamau no ka dizziness.

Ke keu

Ma kahi o kahi overdose, hiki i ka losartan ke hōʻeha i kēia mau maʻi: kahi māhina i hōʻailona i ke koko, bradycardia, tachycardia.

ʻO ka overdose o ka hydrochlorothiazide e hōʻike ʻia e ka nalowale o nā electrolytes (hyperchloremia, hypokalemia, hyponatremia), a me ka dehydration, kahi hopena o nā diuresis nui.

Inā hala kekahi manawa liʻiliʻi ma hope o ka lawe ʻana iā Vazotenza N, ua ʻōlelo ʻia ka lavage gastric. Hoʻonohonoho ʻia ka maʻi Symptomatic a me ke kākoʻo; ʻo ka hoʻoponopono ʻana i ka hoʻopilikia ʻana i ka wai-electrolyte e pono ai. Inā pono, hoʻokō ʻia ka hemodialysis e wehe i ka losartan a me kāna metabolite hoʻoikaika i ke kino.

ʻO ka hole waiwai

I ka wā o ka papa hana, pono ia e nānā i ke kūlana o ka mea maʻi i mea e hoʻomaopopo koke i nā hōʻailona lapaʻau no ka hiki ʻole o ke kue ʻana i ke koena wai-electrolyte, hiki ke kū mai i ka maʻi intercurrent a i ʻole ka luaʻi. I kēlā mau mea maʻi, pono ia e mālama i ka pae o nā electrolytes i ka serum koko.

Hiki i ke Thiazide diuretics ke hana i ka hoʻohaʻahaʻa i ka glucose, e noi ai i ka hoʻoponopono ʻana i nā maʻi hypoglycemic a i ʻole insulin.

Hiki i ka Hydrochlorothiazide ke hoʻohaʻahaʻa i ka excretion calcium urinary, me ke kumu no ka hoʻonui iki ʻana o ka episodic i ka nui o ka nui o nā calcium calcium. Inā ʻike ʻia ka hypercalcemia koʻikoʻi, pono ʻia ka latpar hyperparathyroidism.

Hoʻopilikia ka Thiazides i ka metabolism o ka calcium, no laila hiki iā lākou ke hōʻalo i nā hopena o kahi noiʻi o ke ʻano o nā hana o ka papa parathyroid. I kēia mau mea, ma ka lā o ka hōʻike, pono e hoʻopau ʻia ka lāʻau lapaʻau.

Hiki i ka Hydrochlorothiazide ke hoʻonui i ka triglycerides koko a me ka cholesterol.

I ka wā o ka maʻi, hiki i ka exacerbation a i ʻole ka holomua o ka systemus lupus erythematosus.

Hiki i ka Hydrochlorothiazide ke kūkulu i ka hoʻomohala ʻana o ka hyperuricemia a me / a i ka gout paha. Eia nō naʻe, ʻo losartan, ka lua o ka hana ikaika o Vazotenza N, e hoʻemi ana i ka momona o ka uric acid, no laila, e hōʻemi ana i ka nui o ka hyperuricemia i hoʻoulu ʻia e ka diuretic.

Ma muli o ke ʻano o ka diuretic therapy, hiki i ka hopena o ke ʻano o ka hopena hypersensitivity, ʻoiai i nā mea maʻi me ka mōʻaukala o kahi no nā bronchial asthma a i ʻole allergy.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a me nā mīkini paʻakikī

ʻAʻole i mālama ʻia nā haʻawina loea koʻikoʻi e noi i ka hopena o Vazotenza N ma ka hoʻomohala ʻana a me nā hana psychomotor ʻaʻole pono. Eia naʻe, i ka wā o ka mea maʻi, hānai a lohi paha ka hopena. No kēia kumu, ʻōlelo ʻia ka mālama hoʻomaʻemaʻe i ka wā e hana ana i nā hana e koi ana i ka nānā nui a me ka wikiwiki o ka hopena, e pili ana i ka pae mua o ka hoʻomau a me ka manawa o ka hoʻonui ʻana i ka nui o ka lāʻau.

ʻŌpū a me ka lactation

I ka hoʻohana ʻia ma ka lua a me ke kolu o ka hapē o ka hapai, ʻo ka losartan, e like me nā lāʻau ʻē aʻe e pili ana i ka renin-angiotensin-aldosterone system (RAAS), hiki i kahi mea hoʻomohala a me ka make ʻana paha o ka make.

Hoʻoholo ka Hydrochlorothiazide i ka pale o ka placental, ua hoʻoholo ʻia i ke koko o ke kaula umbilical. I ka wā e hoʻohana ai i ka wā hāpai, hoʻonui ʻia ka hopena o ka jaundice i ka pēpē a i ʻole keiki hou, me ka hoʻōla ʻana o ka thrombocytopenia a me ka nānāʻole i ka mololi electrolyte.

Hoʻopili nā Vasotens N nā papa i ka wā hāpai. Inā ʻike ʻia ka wahine hāpai i ka wā o ka mālama ʻana me ka lāʻau lapaʻau, pono ʻoe e kāpae i ka wikiwiki.

Pākuʻi ʻia ʻo Thiazide diuretics i ka waiū umauma. Hoʻomaopopo ʻia ka wahine e pani i ka hōʻeha o ka umauma inā mālama ʻia ka lāʻau lapaʻau i ka wā lactation.

Hoʻohui nūhou

Hiki ke hoʻohana i Losartan me ka hui pū me nā mea hana antihypertensive (diuretics, sympatholytics, beta-blockers). I kēia hihia, ua ʻike ʻia ka hoʻoikaika ʻana o ka hopena.

ʻAʻohe mea lapaʻau koʻikoʻi ʻoi aku ka hopena me ka hoʻohana like ʻana o ka hydrochlorothiazide, erythromycin, cimetidine, ketoconazole, fenobarbital, warfarin, digoxin.

I ka poʻe maʻi me ka hoʻēmi ʻia BCC ma muli o ka mālama mua ʻana me nā dosis nui o ka diuretics, hiki i ka lāʻau lapaʻau ke hōʻeha i kahi hōʻeha o ke koko.

Me ka hoʻohana pū ʻana o ka diuretics pālani-sparing (amiloride, triamteren, spironolactone), paʻakai kalima a i hoʻomākaukau hoʻomākaukau ʻana paha, hiki ke hoʻonui ʻia ma ke ʻano o ka paʻakai ma ka serum o ke koko.

ʻO Fluconazole a me rifampicin e hōʻemi i ka pae plasma o ka metabolite ikaika o losartan. ʻAʻole paʻa i ke koʻikoʻi kauka ʻo kēia mau pilina.

Hiki i Losartan ke hoʻonui i ka ʻike o ka lithium i loko o ke kaila koko. Ma kēia hana, hiki ke hoʻonohonoho ʻia nā mākau lithium ma hope o ka loiloi ʻana o ka pōmaikaʻi ʻia i nā mea e manaʻo ʻia ana a me nā mea hiki ke pilikia. Ke hoʻohana nei i kēia hoʻohui, pono e mālama pono ʻia ka pilina o ka lithium.

Hiki ke hōʻemi ʻia ka hopena o losartan e nā NSAID, e komo pū ana me nā pipili COX-2 paʻa. I ka poʻe maʻi me ka hana renal impable, i kekahi mau hihia, hiki i kēia hōʻiliʻili ke hāʻawi i ka hoʻomaʻamaʻa hou ʻana i ka hana ʻoi, a hiki i ka hoʻomohala ʻana i ka hana renal ka hopena. Hoʻololi hou kēia hopena.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

i loko o kahi pahu kīlei o 7 pcs., i loko o kahi ʻeke o ka 4 mau kola, a i loko o kahi pahu kī he 14 mau pcs.

i loko o kahi pahu kīlei o 7 pcs., i loko o kahi ʻeke o ka 4 mau kola, a i loko o kahi pahu kī he 14 mau pcs.

Hoʻohui

Hoʻonui ka Losartan i ka hopena o nā lāʻau antihypertensive. No ke ʻano nui o nā maʻi me ka hydrochlorothiazide, digoxin, kūlohelohe anticoagulants, cimetidine, phenobarbital, ketoconazole, erythromycin. Ua hōʻike ʻia ʻo Rifampicin a me fluconazole e hoʻohaʻahaʻa i ka pae o ka metabolite ikaika. ʻAʻole i aʻo ʻia ka maʻi koʻikoʻi o kēia mau pilina.

E like me ka hoʻokō ʻana o nā lāʻau lapaʻau ʻē aʻe e poloka ai i ka angiotensin II a i kāna hana ʻana, ka ka manawa like i ka potassium-sparing diuretics (e.g. spironolactone, triamteren, amiloride), mākaukau potassium, a me nā paʻina paʻakai e pili ana i ka potassium hiki ke alakaʻi iā hyperkalemia.

NSAIDs, e komo hiki ke hōʻemi i nā mea koho COX-2 i ka hopena o nā diuretics a me nā mea hana antihypertensive'ē aʻe.

I kekahi mau mea maʻi me ka hana renal impaired i mālama ʻia me nā NSAIDs (me ka COX-2 inhibitors), lapaʻau me ka angiotensin II receptor antagonist hiki ke hana hou i ka hana hou ʻana o ka hana moloka, e komo pū me ka hana ʻole o ka renal, ka mea maʻamau.

ʻO ka hopena antihypertensive o ka losartan, e like me nā lāʻau antihypertensive, hiki ke nawaliwali i ka wā e lawe ana i ka indomethacin.

Hiki i nā lāʻau lapaʻau ke hiki ke hoʻopili me ka diuretics thiazide me ka hoʻokolohua hoʻokahi ʻana o lākou:

barbiturates, nā lāʻau lapaʻau narkotic, ethanol - hiki paha i ka hypthension orthostatic,

nā mea lawelawe hypoglycemic (nā waha waha a me ka insulin) - ke koi ʻia o ka hoʻoponopono ʻana o nā ʻaihā hypoglycemic,

nā antihypertensives ʻē aʻe - hiki ke hopena hoʻohui

colestyramine a me colestipol - hōʻemi i ke kao o ka hydrochlorothiazide,

corticosteroids, ACTH - hoʻonui i ka nalowale o nā electrolytes, ʻoi loa ka potassium

mea paʻa Amines - paha līwila liʻiliʻi paha i ka hopena o ka pressor amines, ʻaʻole i pili i ko lākou hoʻohana ʻana,

hoʻomaha pīhoihoiʻole (e.g. tubocurarine) - Hiki iā ia ke hoʻonui i ka hana o nā mea hōʻoluʻolu o ka ʻiʻo,

Hoʻomākaukau lithium - hoʻoemi ʻia ka diuretics i ka wehe ʻana i ka wehe a me ka hoʻonui ʻana i ka lithium intoxication, no laila, ʻaʻole i ʻōlelo ʻia ka hoʻohana ʻana i nā manawa like ʻole.

NSAIDs, e komo nā mea koho mole COX-2 - i kekahi mau maʻi, ka hoʻohana ʻana o NSAID, e komo COX-2 inhibitors, hiki ke hōʻemi i ka diuretic, natriuretic a me nā hopena antihypertensive o ka diuretics.

Hoʻokaʻaina i nā hopena laboratory - Ma muli o ka hopena i ka excretion kalsi, hiki i ka thiazides ke hopena i nā hopena o ka hōʻike pānaʻi hana parathyroid.

ʻLoe a me ke kākele

I loko e pili ʻole i ka mea ʻai.

ʻO ka papa ʻōlelo mua a me ka mālama mālama ʻia 1 papa. i ka la. No kēlā mau mea maʻi ʻaʻole hiki ke loaʻa i ka kaohi koko kūpono i kēia maʻa o kēia maʻa, hiki ke hoʻonui ʻia ka nui i loko o ka 2 papa. (50 mg / 12.5 mg) a i ʻole 1 papa. (100 mg / 25 mg) 1 manawa i ka lā. ʻO ka nui loa he 2 papa. (50 mg / 12.5 mg) a i ʻole 1 papa. (100 mg / 25 mg) 1 manawa i ka lā.

Ma keʻano holoʻokoʻa, ua loaʻa ka hopena hypotensive nui i loko o 3 mau pule ma hope o ka hoʻomaka ʻana o ka mālama ʻana.

ʻAʻohe pono no ke koho kūikawā o ka hopena mua no nā mea maʻi.

Nā ʻōlelo kikoʻī

Hiki ke hoʻoholo pū ʻia me nā lāʻau lapaʻau antihypertensive.

ʻAʻohe pono no kahi koho kūikawā o ka hopena mua no nā mea maʻi maʻi.

Hiki i ka lāʻau lapaʻau ke hoʻonui i ke kao o ka urea a me ka mea hana i loko o ke koko koko i loko o nā mea maʻi me ka bilateral renal artery stenosis a renal artery stenosis o hoʻokahi kidney.

Hiki i ka Hydrochlorothiazide ke hoʻonui i ka hypotension arterial a me ka hoʻopalike ʻana me ka hoʻōla wai-electrolyte kīnā (hoʻemi i ka BCC, hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), hoʻohaʻahaʻa ka hoʻohaʻahaʻa glucose, hoʻemi i ka hoʻokaʻawale o ka urinary a me ka hopena o ka transient, hoʻolōʻihi i ka hoʻonui ʻana i ka kolesterol plasma, hoʻonui i ka calcium o ke koko, e hoʻonui a me ka triglycerides, hoʻonāukiuki i ka loaʻa ʻana o hyperuricemia a me / a i ʻole gout.

ʻO ka wehe ʻana i nā lāʻau lapaʻau e hana pololei ana i ka ʻōnaehana renin-angiotensin i ka wā o nā II a me III o nā mea hoʻomaʻamaʻa o ka hapaha hiki ke alakaʻi i ka make o nā keiki. Inā loaʻa ka wā hāpai, lawe ʻia ka haʻalele ʻana i ka lāʻau.

ʻAʻole ka ʻike e pili ana i ka hopena ma ka hiki ke lawe i kahi kaʻa a me nā mīkini ʻē aʻe.

Nā hōʻailona no ka hoʻohana ʻana

Ua kuhikuhi ʻia ka lāʻau lapaʻau no nā mea maʻi me nā pilikia ʻē aʻe:

1. He maʻi haole. Hōʻike ʻia ka lāʻau lapaʻau no nā mea maʻi me ka hypertension. ʻOiai ke lawe nei i ka lāʻau lapaʻau "Vazotens" pono e mālama pinepine i nā ʻōnaehana koko.
2. Hoʻopau ʻole nā ​​puʻuwai naʻau. Me ka hoʻomau ʻana o kēlā ʻano palaualelo, ʻae ʻia ka hoʻololi ʻana o ka puʻuwai i nā mea maʻi. I ka nui o nā hihia, ʻike ʻia ka maʻi e ka poʻeʻelemakule.

Hoʻomaopopo ʻia ka lāʻau lapaʻau "Vazotens" i ka hui pū me nā lāʻau ʻē aʻe. Hoʻomaʻamaʻa maikaʻi ka lāʻau lapaʻau ʻoiai lawe ʻia me nā ACE inhibitors. Pono ke kauka e noʻonoʻo i ka pono o nā lāʻau lapaʻau a me nā ʻano pilikino o ke kino.

Ua kuhikuhi ʻia ka lāʻau lapaʻau no ka hoʻopau ʻana o ka naʻau

Pehea e lawe ai a ma ke kumu a ke kaomi, ka nui

"Vazotens" e kuhikuhi i nā mea maʻi me ke koko kiʻekiʻe. Lawe ʻia ka lāʻau lapaʻau ma ke ʻano, me ke ʻano o ka ʻaina. Pono ʻoe e inu i nā papa 1 i ka manawa i ka lā.

Inā loaʻa nā maʻi i ka maʻi hypertension, hoʻomaka ka lāʻau ma kahi hōʻemi haʻahaʻa. Kuhi ʻia ka mea maʻi i ka 50 mg o losartan. Inā pono a e like me ka hōʻike a ke kauka, hiki ke hoʻonui ʻia i ka nui ma 100 mg. A laila māhelehele ʻia ka helu i ʻelua mau puʻupuʻu - i ke kakahiaka a me ke ahiahi.

ʻO ka poʻe me ka nele i ka naʻau e pono e lawe i nā lāʻau lapaʻau liʻiliʻi liʻiliʻi. ʻO ka lāʻau mua ma 12.5 mg hoʻokahi i ka lā. Inā hoʻomanawanui maikaʻi ka mea maʻi i ka mālama ʻana ma hope o nā lā 7-10 e hoʻonui ai ka nui.

Lapaʻau

ʻO ka Vazotens ka lāʻau lapaʻau e pili ana i nā lāʻau antihypertensive - antagonist kikoʻī o ka ʻāneʻala o ka angiotensin 2. ʻaʻole e hoʻouka i ka kinase enzyme, ka mea e hoʻopau ai i ka bradykinin. He hopena ka hopena o ka lāʻau i ka diuretic, ʻaʻole i hoʻopilikia i ka ʻike o adrenaline, aldosterone i loko o ka plasma.

Ma muli o ka hana a ka lāʻau lapaʻau, ʻaʻohe ulu ka hypertrophy o nā myocardial arteries, ka hoʻomanawanui ʻana i ka hoʻoikaika kino me ka hōʻeha ʻole o ka naʻau. Ma hope o hoʻokahi wai o nā papa, e hoʻemi ana ke kaomi, hiki i ka hopena ma hope o 6 mau hola a kū i ka lā. Hōʻike ka maikaʻi o ka lāʻau lapaʻau i nā lā 3-6 pule o ka mālama ʻana. Me ka cirrhosis o ke ake, ke hoʻonui nei ke ʻano o ka mea hana, no laila e koi ʻia kahi hoʻoponopono hoʻoponopono.

Hoʻopau koke ʻia ʻo Losartan ma loko o ka ʻōpū, loaʻa a 33% bioavailability. Ua hiki i ka waiwai ke koʻo i ka lōʻihi ma hope o hoʻokahi hola, ka metabolite ikaika - ma hope o 3-4 mau hola. ʻO ka hapalua o ka ola o ka losartan he 1.5-2 mau hola, ʻo ka metabolite he 6-9 mau hola. Hoʻokomo ʻia ka hapakolu o ka ʻauʻau i ka urine, ke koena me nā feces.

ʻO ka hui o Vazotenza N me kahi diuretic hydrochlorothiazide, e pili ana i kahi ʻano thiazide-type. Hoʻemi ia i ka reabsorption o ka paʻakai sodium, hoʻonui i ka excretion o ka urine phosphates, bicarbonate. Ma ka hoʻemi ʻana i ka nui o ke kahe o ke koko, e hoʻemi ana ka nui, ka hoʻololi ʻana o ka pā vascular, e hoʻemi ana ka hopena o ka vasoconstrictors, a me ka hopena hōʻeha i ka ganglia e hoʻonui.

ʻLoe a me ke kākele

ʻO nā papa Vazotens e lawe ʻia i ka lā hoʻokahi. Me ka hypertension, ʻo ka nui o kēlā me kēia lā he 50 mg, i kekahi manawa ke hoʻonui ʻia ʻo 100 mg ma ka 1-2 dosis. Ma ka nele o ka puʻuwai, ʻo ka dosage mua he 12.5 mg hoʻokahi i ka lā. Hoʻonui ʻia ka nui i kēlā me kēia pule e 12.5 mg e hōʻea i 50 mg hoʻokahi i ka lā. Me ka hoʻokolohua hoʻohālikelike o ka diuretics, ua hoʻemi ʻia ka lāʻau mua ma 25 mg i kēlā me kēia lā.

Ma ka hihia o ka hana leka hemahema (hōʻemi i ka hoʻoma ʻana o ka likinine), ua emi ka dosage, i ka wā ʻelemakule, me ka loaʻa ʻole o ka pūhaka, dialysis, ʻaʻole i hana ʻia ka hoʻoponopono ʻana. Hōʻike ʻia ka hopena kiʻekiʻe ma hope o 3 mau pule o ka mālama ʻana. I ka lāʻau lapaʻau, ʻaʻole i hoʻohana ʻia ka lāʻau lapaʻau. Nā ʻōlelo kikoʻī kūikawā no kona hoʻohana ʻana mai nā ʻōlelo ʻōlelo:

1. Ma mua o ka kuhikuhi ʻana i kahi lāʻau lapaʻau, hana ʻia ke hoʻoponopono ʻia ʻana o ke kaumaha, a pono ʻoe e hoʻohana i ka lāʻau lapaʻau ma kahi haʻahaʻa haʻahaʻa.
2. Hiki i ka paahana ke hoʻonui i ke kao o ka urea i ke koko me ka stenosis renal.
3. I ka wā o ka papa hana, pono ia e kāohi i ka pae o ka pāhana i loko o ke koko, ʻoi aku ka poʻe makua, no ka mea he nui ka nui o nā mea maʻi e hoʻonui i ka ulu ʻana i ka hyperkalemia (hoʻonui i nā pae o ka pāhana potassium i loko o ke koko koko).
4. ʻO ka hoʻohanaʻana i ka lāʻau lapaʻau i ka wā hāpai e hiki ke hoʻomau i kahi maʻi hoʻomohala a i ʻole ka make a kaʻi ʻana. Me ka lactation, pāpā ʻia ka hoʻohana ʻana o nā vasotens.

Nā ʻōlelo a ke kūʻai a me ka waiho ʻana

ʻO Vazotens e pili ana i nā lāʻau lapaʻau i mālama ʻia, mālama ʻia i nā mahana a hiki i ke 30 kiʻekiʻe no ka 2 mau makahiki, ʻaʻole i hiki i nā keiki.

Hiki i nā antihypertensive a me nā mea like ʻole ke hoʻololi i ka lāʻau. ʻO nā ʻōhua Vazotens:

• Lorista - Nā papa hana ma luna o losartan,
• ʻO Lozap kahi papa papa e loaʻa ai ka losartan ma ke ʻano he mea ikaika.

Inoa Kūʻai ʻole honua

INN o ka lāʻau lapaʻau ka losartan.

Hoʻolaha pinepine ʻia nā lāʻau Vasotens no nā poʻe e loaʻa ana i ka hypertension arterial.

I ka papa inoa o nā ATX honua, ua loaʻa kēia lāʻau lapaʻau i ka code C09CA01.

E hoʻokuʻu i nā palapala a me ka ʻano

ʻO ka waihona hana nui o Vazotens ʻo ka potassium losartan. ʻO nā kumuwaiwai hou o ka lāʻau lapaʻau ka ʻano sodium croscarmellose, mannitol, hypromellose, magnesium stearate, talc, propylene glycol, etc. ʻO ka huiʻana o Vazotenza N, i ka hoʻohui ʻana i ka losartan, ka hydrochlorothiazide.

Loaʻa nā Vasotens i nā ʻaoʻao o nā papa me ke kaha o 25, 50 a me 100 mg. Hoʻokaʻa ʻia nā papa papa i kona ʻano. Ua uhi ʻia lākou me kahi lei keʻokeʻo a kāhea ʻia ʻo "2L", "3L" a i ʻole "4L" hilinaʻi i ka ʻimi. Hoʻopili ʻia lākou ma nā lepili o 7 a 10 mau pcs. I loko o kahi pahu pahu kahi aia he 1, 2, 3 a i ʻole 4 mau blisters a me kahi pepa aʻoaʻo me ka ʻike e pili ana i ka lāʻau lapaʻau.

Loaʻa nā Vasotens i nā ʻaoʻao o nā papa me ke kaha o 25, 50 a me 100 mg.

Ka hana lāʻau lapaʻau

ʻO nā ʻano pharmacological o ka lāʻau lapaʻau ma muli o nā hana hypotensive i haʻi ʻia mai o Vazotenz, ka māhele koʻikoʻi o ia ʻano he ala 2 angiotensin receptor antagonist. Me ka maʻi vasotenz, ka mea ikaika o ka lāʻau lapaʻau e kōkua i ka hōʻemi i ka OPSS. ʻO ka lāʻau lapaʻau e hoʻohaʻahaʻa i ke kahe o ke aldosterone a me adrenaline i loko o ke koko koko. Ua loaʻa kēia lāʻau lapaʻau i ka hopena hui, e hāʻawi i ka hoʻololi ʻia o ke kaomi ma ka pulmonary circulation a me ka pulmonary circulate.

Eia kekahi, ʻo nā mea ikaika o ka lāʻau lapaʻau e hōʻemi i ka ukana ma ka ʻōnaehana cardiovascular a loaʻa kahi hopena diuretic. Ma muli o ka hopena paʻakikī, ʻo ka mālamaʻana me nā vasotens e hōʻemi i ka hopena o ka myocardial hypertrophy. Ke kōkua nei kēia lāʻau lapaʻau i ka hoʻonui ʻana i ka hoʻolahalaha o nā maʻi i nā maʻi me nā hōʻailona koʻikoʻi o ka hiki ʻole o ka naʻau.

ʻAʻole hōʻalo ka lāʻau lapaʻau i ka hana o ka kinase type 2. ʻO kēia kaomi i ka hopena luku i ka bradykinin. Ke lawe nei i kēia lāʻau lapaʻau, ʻikeʻia ka emi ʻana o ke koko ma hope o nā hola 6. I ka wā e hiki mai ana, ʻo ka hana o ka mea ikaika o ka lāʻau lapaʻau e emi iki ana i 24 mau hola. Me ka hoʻohana ʻana i ka ʻōnaehana kikoʻī, ʻike ʻia ka hopena loa ma hope o 3-6 mau pule. Pēlā, pono ka lāʻau i ka hoʻohana ʻana i ka ʻōnaehana ʻana.

Me ka mālama pono

Inā loaʻa i ka mea maʻi nā hōʻailona o ka pōpoki o ke ake a me nā hana moliki, ʻo ka mālama ʻana me Vazotens e koi kūikawā i ke kauka. Eia kekahi, pono ka mālama kūikawā e hoʻohana i nā vazotens i ka mālamaʻana i ka poʻe e loaʻa ana i ka maʻi Shenlein Genoch. I kēia hihia, koi ʻia ka hoʻoponopono pinepine ʻana i ka hapa o ka lāʻau no ka hōʻemi ʻana i ka hoʻonāukiuki ʻana i ka hoʻopiʻi koʻikoʻi.

Pehea e lawe ai i nā vasotens?

Kuhi ʻia kēia lāʻau lapaʻau no ka mālama ʻana i ka waha. No ka hoʻokō i ka hopena therapeutic, pono i ka mea maʻi ke kau i ka wai i hōʻike ʻia i ka manawa 1 i ke kakahiaka. ʻAʻole ʻai i ka ʻai i ka hoʻopili ʻana o ka lāʻau lapaʻau. E hoʻomau i ka pīhoihoi koko a mālama iā ia i kahi pae maʻamau, hōʻike ʻia nā mea maʻi e lawe iā Vazotenza ma ke ʻano o 50 mg i kēlā me kēia lā. Inā pono, hiki ke hoʻonui ʻia i kēia maʻa i 100 mg i kēlā me kēia lā.

Inā loaʻa i ka mea maʻi ka hōʻailona o ka hana a ka puʻuwai, e hoʻonui nui ʻia ka nui o nā vasotenz. ʻO ka mea mua, ua kuhikuhi ʻia ka mea maʻi i ka lāʻau lapaʻau ma kahi o 12,5 mg i kēlā me kēia lā. Ma hope o hoʻokahi pule, e hoʻonui ka nui i ka 25 mg. Ma hope o kahi mau lā 7 o ka lawe ʻana i ka lāʻau, ala i kona hōʻeha ke 50 mg i ka lā.

Inā loaʻa i ka mea maʻi nā hōʻailona o ka hana lōkū o ka ate, mālama ʻia me Vasotens e pono ai ka makaʻala kūikawā o ke kauka.

Pūnaehana pīhoihoi waena

Ma kahi o 1% o nā maʻi e kau ana ma ka vasotens therapy e loaʻa ana nā hōʻailona ashenia, nā kuʻuna, a me ka maʻi ʻole. ʻO nā hue ʻana o ka hiamoe, ke hiamoe kakahiaka, ka hana naʻau, nā hōʻailona o ka ataxia a me nā neuropathy peripheral i nā hanana ka hopena hiki ke neʻe i ka wā o ka mālama ʻana me vasotenz. Hiki i nā ʻono ke hoʻōki ʻia a me ka pohō ʻana paha. Eia kekahi, aia kahi pilikia o ka hōʻoluʻolu o ka wāwae hema.

Mai ka pūnaehana genitourinary

ʻO ka lawe ʻana i nā vasotenza hiki ke hoʻokumu i nā kūlana no ka hoʻomohala ʻana i nā maʻi maʻi infectious o ka maʻi urinary. I nā hihia pinepine, loaʻa i nā maʻi ke hoʻopiʻi pinepine o ka urination a me ka hana renal impaired. I nā kāne, me ka vasotenz therapy, hiki ke mālama ʻia i ka emi ʻana o ka libido a me ka hoʻomohala ʻana o ka impotence.

Loaʻa paha ke ʻano o ka ʻili maloʻo.

Mai ka pūnaehana cardiovascular

Me ka hoʻomehana lōʻihi o vasotenz, hiki i ka mea maʻi ke hoʻomohala a orthostatic hypotension. Hiki ke hoʻoweliweli ʻo Angina a me tachycardia. I nā pilikia pinepine, lawe i ka lāʻau lapaʻau ke kumu o ka anemia.

ʻO ka manawa pinepine loa, ʻo ka hoʻohana ʻana o vasotenz e hōʻeha i ka hopena aler i ka maʻi maʻi, i hōʻike ʻia e ka puhaluhi, urticaria, a i ʻole ka ʻāʻī. Maʻalahi loa ka nānā ʻana i ke kūkulu ʻana o ka angioedema.

Hoʻohana i ka wā hāpai a me ka lactation

ʻO ka maikaʻi a me ka palekana o ka hoʻohana ʻana i vasotenza i ka wā hāpai a ʻaʻole i aʻo nui ʻia. Ma kēia hihia, ʻike nō ka hopena maikaʻi ʻole o ka waiwai ikaika o ka lāʻau lapaʻau ma ka pūpū ma ka 2 a me ka 3 o ka hapē o ka hapai. Hoʻonui kēia i kahi pilikia o kahi keiki e hoʻomohala ana i nā hana ʻino maikaʻi ʻole a me ka make intrauterine. Inā pono, mālama ʻia ka hōʻole ʻana i ka umauma umauma.

Me ka hoʻomehana lōʻihi o vasotenz, hiki i ka mea maʻi ke hoʻomohala a orthostatic hypotension.

ʻO nā kumukūʻai no nā vasotens

ʻO ke kumukūʻai o ka lāʻau lapaʻau i nā halihali mai 115 a 300 rubles paha, e pili ana i ka dosis.

ʻO kekahi o nā mea kaulana kaulana o ka lāʻau lapaʻau ʻo Lozap.
ʻO Cozaar kahi mea hoʻohālike o ka lāʻau Vazotens.
ʻO kahi lāʻau like me Presartan.
ʻO ka hoʻohālikelike o ka lāʻau Vazotens ʻo Lorista.ʻO Lozarel kekahi o nā kaona ʻike kaulana kaulana o ka lāʻau Vazotens.

Cardiologists

Grigory, 38 makahiki, Moscow

Ma kaʻu hana lapaʻau, hoʻolaha pinepine wau i ka hoʻohana ʻana o nā vazotens no nā poʻe maʻi e loaʻa nei i ka hypertension arterial. Ma muli o ka hopena hypotensive a me ka diuretic, ʻaʻole i hāʻawi wale ka lāʻau i ka maʻamau o ke kaila o ke koko, akā hoʻonui pū ka hoʻomanawanui i ka hana kino a hōʻemi i ka hōʻeha o ka edema. Hoʻomaʻamaʻa maikaʻi ʻia ka lāʻau e ʻo nā mea maʻi ʻoʻōpio. Eia kekahi, he kūpono ia no ke komo ʻana i ka lāʻau paʻakikī e hoʻohana ana i nā lāʻau antihypertensive hou.

Irina, he 42 makahiki, Rostov-on-Don.

Ua hana wau ma kahi cardiologist no ʻoi aku ma mua o 15 mau makahiki, a me nā mea maʻi e loaʻa ana i nā hoʻopiʻi o ke koko kiʻekiʻe e kuhikuhi pinepine iā Vazotens. ʻO ka hopena o kēia lāʻau lapaʻau i ka hapa nui he lawa e mālama ai i ke kaomi maʻamau me ka nele o ka pono e hoʻohana i ka diuretics. Hoʻomaʻamaʻa maikaʻi kēia lāʻau lapaʻau e nā mea maʻi a hiki i nā hopena hopena. Mahalo i kēia, hiki iā ʻoe ke hoʻohana pono iā ia i nā papa lōʻihi.

Igor, 45 makahiki, Orenburg

Hoʻomaopopo pinepine wau i ka hoʻohana ʻana i vasotenza no nā poʻe maʻi e hōʻeha nei i ka puʻuwai naʻau. Hāʻawi ka lāʻau lapaʻau iā ʻoe e hoʻokō pono i ka normalization o ke koko a hōʻemi i ka nui o ka edema o nā pae haʻahaʻa. E hele pono ka hāmeʻa me nā lāʻau ʻē aʻe i hoʻohana ʻia i ka mālama ʻana i kēia ʻano pathological. Ma koʻu mau makahiki he nui o ka hoʻomaʻamaʻa, ʻaʻole au i ʻike i ke ʻano o nā hopena olakino i nā maʻi e hoʻohana ana i nā vazotens.

I ka wā e hoʻohana ai i ka lāʻau lapaʻau, pono e mālama pono e mālama i nā ʻano paʻakikī.

Margarita, 48 makahiki, Kamensk-Shakhtinsky

Ua kamaʻāina wau i ka pilikia o ke koko koko nui ma mua o 15 mau makahiki. I ka manawa mua, ua ʻōlelo nā kauka i ka hōʻemi ʻana i ka paona, hele mau nei i ka ea hou a me ka ʻai pono ʻana, akā nīnū nui ka pilikia. I ka hoʻomaka ʻana o ke kaomi e hoʻomau i ka 170/110, hoʻomaka nā kauka e kau i nā lāʻau lapaʻau. ʻO nā makahiki i hala aku nei iaʻu i mālama ʻia ai me Vazotens. Hāʻawi ka mea hana i ka hopena maikaʻi. Lawe au i kakahiaka. Ua hoʻomau aku ka paʻakikī. Holo aku ka ʻōpū o nā wāwae. Ua hoʻomaka ʻo ia e ʻoliʻoli hou aku. Hāʻawi ʻia nā ʻōpū piʻi i kēia manawa me ka pōkole o ka hanu.

Andrey, 52 makahiki, Chelyabinsk

Lawe ʻo ia i nā ʻano lāʻau lapaʻau like ʻole. No kahi makahiki a hoʻokahi, ua kuhikuhi kekahi kaila maʻi i ka hoʻohana ʻana i nā vazotens. Hāʻawi ka mea hana i ka hopena maikaʻi. Pono ʻoe e lawe i hoʻokahi manawa wale i kēlā me kēia lā. Ua hoʻi hou ʻia ka pēpē maʻamau i loko o 2 mau pule o ka hoʻokomo. Eia wau ke lawe i kēia lāʻau lapaʻau i kēlā me kēia lā. ʻAʻole au i nānā i nā hopena ʻaoʻao.