Noho ka Sitagliptin e kaohi i ka momona a me ke kaumaha o ke kino

Loaʻa ka sitagliptin i ke ʻano o ka nui o ka protein phosphate. ʻO ka puka i hoʻokuʻu ʻia he papa pākuhi ʻoniʻoni

Heʻokoʻa nui ka hāmeʻa i kona papa kemana a me ka hana pharmacological mai nā analogue a me nā ala o ka sulfonylureas, biguanides a me nā alpha-glycosidase inhibitors.

Ke hōʻike nei o DPP 4 me Sitagliptin alakaʻi i ka hoʻonui ʻia ʻana o ka neʻe ʻana o ʻelua mau huahana GLP-1 a me HIP. Aia kēia mau keiki i ka ʻohana palupalu. ʻO ka huna ʻia o kēia mau hormones e lawe i loko o ka ʻawaʻawa.

Ke hoʻonui ʻia nei ke ʻano o kēia mau hana ma muli o ka ʻai ʻana. ʻO ka incretins he ʻāpana o ka ʻōnaehana physiological e hoʻoponopono i ka homeostasis gula i loko o ke kino.

ʻO nā lāʻau lapaʻau a me nā hōʻailona no ka hoʻohana ʻana i ka lāʻau

Ma hope o ka lawe ʻana i ka lāʻau, hoʻopili koke ʻia ka lāʻau. Loaʻa i kēia lāʻau lapaʻau ka bioavailability piha loa o ka 87%. ʻAʻole komo ka hopena o ka ʻai momona i ka kinetika pharmacological o ka lāʻau.

Lawe ʻia ka hoʻokaʻawale ʻana o ka lāka ma ke ʻano he loli a me ka hoʻoneʻe ʻana i ka urine. Ma hope o ka hoʻopaʻa ʻana i ka lāʻau lapaʻau no hoʻokahi hebedoma, 87% me ka urine a me 13% me nā feces i hoʻopau ʻia.

Hoʻohana ʻia ka lāʻau lapaʻau i ke ʻano o ka monotherapy i mua o ka maʻi II mellitus type II i kahi mea maʻi. Ke kiʻi ʻia ka lāʻau e pili ana i ka ʻokoʻa. Hiki ke hoʻohana ʻia ʻo Sitagliptin me Metformin i kahi hoʻohui paʻakikī ma ke alo o ke ʻano type type diabetes mellitus. ʻO ka ʻōlelo e manaʻo ʻia ai ka lawe ʻana i ka lāʻau lapaʻau me ka hui pū ʻana me Metformin he 100 mg hoʻokahi i ka lā.

Inā e lilo ʻoe i ka manawa e lawe ai iā Sitagliptin, pono ʻoe e lawe koke ʻia. ʻO kēia ma muli o kaʻoiaʻiʻo i ka loaʻa ʻole o kahi ʻelua ʻelua o ka lāʻau.

Hōʻike ʻia ka lawe ʻana i ka lāʻau lapaʻau pinepine pinepine ma mua o ke ʻano i nā kuhikuhi no ka hoʻohana.

Hāʻawi ka hāmeʻa iā ʻoe e kāohi i ke kiʻekiʻe o ke kō i loko o ke kino, akā ʻaʻole lapaʻau kēia lāʻau lapaʻau i ka maʻi diabetes.

Pono ka lāʻau e hoʻokaʻawale paha inā maikaʻi ke ʻano o ka mea maʻi, e hoʻihoʻi ʻia ka lāʻau lapaʻau wale nō ma hope o ke kūkā kamaʻilio ʻana me ke kauka hele ʻana a me kāna ʻōlelo.

Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau

ʻO ka Sitagliptin kahi lāʻau lapaʻau i hoʻāno maikaʻi ia i ka wā e lawe ʻia ai e nā mea maʻi, ma ka wā monotherapy a ma ke ʻano he lāʻau paʻakikī i nā lāʻau lapaʻau hou e loaʻa nā mea hypoglycemic.

ʻO ka hoʻoneʻe ʻana i ka hopena nui o ka lāʻau lapaʻau ma o nā keiki. ʻO kēia keʻae o ka wehe ʻana i ka waiwai ikaika mai ke kino e koi ai i ke kauka komo e loiloi i ka hana o nā kuhi ma ka neʻe ʻana o ka hana ʻole i ka maʻi i ka mea maʻi ma mua o ka hoʻohana ʻana i ka lāʻau. Inā kūpono, mālama ʻia kahi hoʻoponopono o ka lāʻau lapaʻau. I mua o kahi ʻano hoʻohālikelike o ka pau ʻole o ka renal, ʻaʻole i hoʻokō ʻia ka hoʻoponopono ʻia ʻana o ka lāʻau.

Inā pilikia ka maʻi i kahi palaka wikiwiki, ʻaʻole pono ka nui o ka lāʻau lapaʻau ma mua o 50 mg hoʻokahi i ka lā. Hiki i ka lāʻau lapaʻau ke hoʻohana i kēlā me kēia manawa, me ke ʻano o ka dialysis prosedur.

Ke hoʻohana nei i ka lāʻau lapaʻau ma ke ʻano o ka lāʻau paʻakikī, i mea e pale ai i ka hoʻomohala ʻana o ka hypoglycemia sulfon-induced i loko o ke kino, e hoʻemi ʻia ka nui o nā derivatives sulfonylurea e hoʻohana ʻia.

ʻO ka hoʻoholo ʻana i ka lāʻau lapaʻau i hoʻohana ʻia e ka mea hele i ke kauka ma hope o ka nānā ʻana i ke kino o ka mea maʻi e hōʻeha ʻia mai i ka maʻi diabetes type 2.

Inā kānalua ka ulu ʻana o ka hoʻomohala i ke kino o ka maʻi pancreatitis, pono ke kāpae i ka lawe ʻana i Sitagliptin a me nā lāʻau ʻē aʻe e hiki ke hoʻonāukiuki i kahi exacerbation o nā maʻi.

Ma mua o ka hoʻohana ʻana i ka lāʻau lapaʻau, pono e hōʻike ke kauka i ka mea maʻi e pili ana i nā hōʻailona mua o ka maʻi pancreatitis.

Nā hiʻohiʻona a me nā hopena ʻaoʻao

Hiki i ka hoʻohana ʻana i ka lāʻau lapaʻau ke hoʻonāukiuki i kahi maʻi koʻikoʻi a me ka hoʻoweliweli ʻana o ka pancreas i loko o ke kino o ke kanaka.

Me ka hoʻohana pono ʻole o ka lāʻau lapaʻau, hiki iā ia ke hoʻonāukiuki i ka hopena o ka nui o nā hopena ʻaoʻao i ke kino. Ke kuhi ʻia nā hōʻailona mua o ka lawehala, e nīnau koke i kahi kauka.

Ke hoʻohana ʻia nei i ka lāʻau lapaʻau, pono e hāhai ʻia nā ʻōlelo e hāʻawi ʻia e ke kauka.

I ka wā e hoʻohana ai i ka lāʻau lapaʻau, hiki i kekahi ke loaʻa i kahi nui o nā hopena ʻokoʻa. ʻO nā hopena nui, ka:

1. angioedema,
2. anafilelixis,
3. ʻohiʻala
4. ʻili vasculitis
5. urticaria
6. maʻi maʻi ʻāpiopio, maʻi o Stevens-Johnson,
7. maʻiʻo pancreatitis
8. ka hoʻonāukiuki o nā keiki o ka huehue, mākā o ka huehue i ka huehue e koi ana i ka dialysis,
9. nasopharyngitis,
10. nā maʻi ʻōpū
11. utuka
12. constipation
13. lie kanikela
14. myalgia
15. aolaila
16. ʻeha ke kaumaha
17. ʻeha hōʻeha
18. pohuo

Ke hoʻohana ʻia ka lāʻau lapaʻau, pono e hāpai ʻia i loko o ka manaʻo e pili ana ka nui o nā contraindications i ka hoʻohana ʻia ʻana o kēia pono hana.

ʻO nā kumumanao nui e lawe i ka lāʻau lapaʻau e like me kēia:

• haaheo
• ka hele ʻana o ka maʻi mellitus o ke ʻano mua,
• maʻi maʻamau ketoacidosis,
• ʻO nā makahiki ahonui ma lalo o ka 18 makahiki
• lactation wā
• ka manawa e hānau ai ke keiki.

Ke hoʻohana nei i kahi lāʻau lapaʻau, pono e hāhai ʻia nā ʻōlelo a pau, a pono ʻole e lawe ʻia ka lāʻau inā loaʻa nā ʻōmole. Inā hele ʻia kahi overdose a i ʻole ka hōʻalo ʻana ma muli o ka lawe ʻana i ka lāʻau lapaʻau, pono ʻoe e kāhea koke i kahi ambulance.

ʻO kahi overdose a i ʻole hōʻino ʻia o ke kino me ka lāʻau hōʻike i hōʻike ʻia e hoʻonāukiuki i nā pilikia olakino nui a hiki i ka make.

ʻO nā moʻomeheu, nā kumukūʻai a me ka launa pū me nā ʻano ʻē aʻe

I ka wā o ka hoʻāʻo ʻana i ka lāʻau lapaʻau, ʻaʻole i loaʻa ka hopena nui a me ka hopena nui i nā kinetics pharmacological o nā lāʻau like e like me ka rosiglitazone, metformin, glibenclamide, warfarin, simvastatin, a me nā mea hoʻohālikelike waha.

Ke hoʻohana nei i nā mea hoʻohana e pili ana i ka sitagliptin, inhibition o CYP2C8, CYP3A4, CYP2C9 isoenzymes ʻaʻole hele mai. Eia kekahi, ʻaʻole e pale ka lāʻau lapaʻau i kēlā mau enzyme CYP1A2, CYP2D6, CYP2B6, CYP2C19.

ʻO ka hoʻohana pū ʻana o ka sitagliptin a me ke metformin ʻaʻohe loli nui i loko o ka pharmacokinetics o sitagliptin i ka maʻi diabetes mellitus.

ʻO ka lāʻau lapaʻau maʻamau loa ʻo Januvia. ʻO kahi hoʻohālikelike o ka lāʻau Lūkia ʻo Januvia ʻo Yanumet, nona ke kumukūʻai ma Lūkia e pili ana i 2980 rubles.

Ma ka hoʻoholo ʻana e nā loiloi o nā poʻe maʻi i hoʻohana i kēia lāʻau lapaʻau no ka mālama ʻana, he hopena koʻikoʻi ka nui o ke kō o ka honi ma loko o ke kino, akā koi ia i ka mana paʻa o ke ʻano o ke kino ma muli o ka hiki ʻana mai o kekahi helu nui o ka hopena.

Ua kau ʻia ke kumukūʻai o ka lāʻau lapaʻau ma ka ʻāina o ka'āina a me ka paʻi o ka lāʻau lapaʻau a ma waena mai 1596 a 1724 mau rubles. ʻO ke wikiō ma kēia ʻatikala e kamaʻilio e pili ana i nā ala e mālama ai i ka glycemia.

E hoʻokuʻu i ke ʻano a me ka ʻano

Loaʻa ka lāʻau lapaʻau e pili ana i sitagliptin me ka inoa inoa ʻo Januvia i ka puka o nā papa pōʻai me ka ʻulaʻula a i ka beige hue a hōʻailona ʻia "227" no 100 mg, "112" no 50 mg, "221" no 25 mg. Hoʻopili ʻia nā papa ma nā pahu palaka a i ʻole nā ​​hihia penikala. Hiki i kekahi mau papa i kahi pahu.

Hoʻopili ʻia ka waihona mea kanu sitagliptin phosphate hydrate i ka sodium croscarmellose, magnesium stearate, cellulose, sodium stearyl fumarate, unrefined calcium hydrogen phosphate.

No ka sildagliptin, hilinaʻi ke kumukūʻai ma ke paena, kūikawā no nā papa 28 e pono ai ʻoe e uku i ka 1,596-1724 rubles. Hāʻawi ʻia kahi lāʻau lapaʻau, ʻo ka ola o ka papa i 1 makahiki. ʻAʻole pono ka lāʻau lapaʻau i nā kūlana kūikawā no ka mālama. Mālama ʻia ka ʻōpiopio paʻa i ka puka o ka pahu pouaka no hoʻokahi mahina.

Lapaʻau Sitagliptinum

Hoʻāla ʻia kēia mau hormones e ka mucosa ʻōpū, a hoʻonui ʻia ka hoʻoulu ʻana o nā huaole me ka makemake o nā mea kanu. Inā he kūleʻa a kiʻekiʻe ka pae glucose, e piʻi ka nui o nā hormones a hiki i ka 80% o ka hana o ka insulin a me kāna neʻe ʻana e nā cells-cell ma muli o ka hōʻailona hōʻailona i nā hana ma loko o nā pū. Mālama ka GLP-1 i ka mea huna kiʻekiʻe o nā b-cell o ka testosteroneagon.

ʻO ka emi ʻana o ke kaʻe o ka glucoseagon e kūʻē i ka mua o ka hoʻonui ʻana i ka nui o ka insulin i mea e hōʻemi ai i ka hoʻokaʻawale i nā mea huna glucose i loko o ka ate. Ke hana nei kēia mau hana a hōʻoia i ka maʻamau o ka glycemia. Hoʻohālikelike ʻia ka hana o nā incretins e kekahi ʻano pilikino, me ka hypoglycemia, ʻaʻole lākou e pili i ka synthesis o ka glucoseagon a me ka insulin.

Ke hoʻohana nei i DPP-4, e hoʻokaʻawale ʻia nā kūmole pane e hana i nā metabolites inert. Ke hāpai nei i nā hana o kēia enima, hoʻonui ka sitagliptin i ka ʻike o ka incretins a me ka insulin, e hoʻemi ana i ka hana o glucagon.

Me ka hyperglycemia, kekahi o nā hōʻailona nui o ka diabetes type 2, ʻo kēia ʻano hana e kōkua i ka hōʻemi ʻana i ka pae o ka hemoglobin glycated, ke kōʻai holi a me ka glucose ma hope o ka ukana o ka haʻaleka. Hiki i hoʻokahi dosis o sitagliptin ke kāohi i ka hana o DPP-4 no hoʻokahi lā, e hoʻonui ana i ke kahe o nā incretins i ke koko i nā manawa he 2-3.

Pharmacokinetics o sitagliptin

Hoʻopuka koke kahi komo o ka lāʻau, me ka bioavailability o 87%. ʻAʻole paʻa i ka manawa lawe ʻole i ka manawa o ka hoʻokomo a me ka hoʻohui ʻana o ka meaʻai, i ka mea kūikawā, ʻaʻole e loli nā meaʻai momona i nā ʻano pharmacokinetic o ka mimetin mimetin.

Ma ka hoʻohālikelike, hoʻonui ʻia ka hoʻohana hou o kahi papa 100 mg i ka wahi ma lalo o ka AUC curve, e hōʻike ana i ka hilinaʻi o nā kaila apana i ka manawa, ʻo 14%. ʻO kahi waihona hoʻokahi o nā papa āpau o 100 mg e hōʻoia i ka laha unihue o 198 l.

Ua hoʻohuihui ʻia kahi ʻāpana liʻiliʻi o ka incretin mimetic. Ua hōʻike ʻia ʻeono mau metabolites no ka nele ʻole o ka hiki ke kāohi iā DPP-4. Hoʻolaha ʻo Renal (QC) - 350 ml / min. ʻO ka hapa nui o ka lāʻau lapaʻau e hoʻopau ʻia e nā keiki (79% i loko o ke ʻano o ke ʻano a me 13% i loko o ke ʻano o ka metabolites), ke koena ka mea i hoʻopau ʻia e nā ʻāpana.

I ka ʻike ʻana o ka hana kaumaha ma luna o nā pēpē i loko o kahi maʻi maʻi me kahi ala koʻikoʻi (CC - 50-80 ml / min.), Ua like nā hōʻailona me ka CC 30-50 ml / min. ua nānā ʻia kahi kānalua o nā waiwai AUC, me CC ma lalo o 30 ml / min. - ʻehā mau manawa. Manaʻo kēia mau ʻano i ka dosis titration.

Me nā ala hepatic o ka hōʻeha paʻakikī, hoʻonuiʻia ka Cmax a me AUC ma ka 13% a me 21%. Ma nā hiʻohiʻona koʻikoʻi, ʻaʻole loli nui ka pharmacokinetics o sitagliptin, no ka mea, ua hoʻopuka mua ʻia ka lāʻau lapaʻau e nā keiki.

ʻO wai e hōʻike ʻia ana o ka incretinomimetic

Ua kuhikuhi ʻia ka lāʻau lapaʻau no ka maʻi maʻamau o ka 2 ma kahi o ka lāʻau haʻahaʻa-haʻahaʻa a me ka hana haʻuki kūpono.

Hoʻohana ʻia ia me ka lāʻau hoʻokahi a me ka hui pū ʻana me ka metformin, sulfonylurea hoʻomākaukau a i ʻole thiazolidinediones. Hiki nō hoʻi ke hoʻohana i ka inika injection i hoʻoponopono ʻia inā he kōkua kēia koho e hoʻonā i ka pilikia o ka kū ʻana o ka insulin.

ʻO nā maʻi no ka sitagliptin

Mai kuhikuhi i nā lāʻau lapaʻau:

• Me ka naʻauao kūʻokoʻa kiʻekiʻe,
• ʻO ka maʻi maʻi maʻi me ka maʻi ʻano ʻehā,
• ʻO ka ʻōpū a me ka umauma,
• I kahi kūlana o ka maʻi ketoacidosis maʻi,
• I na keiki.

Pono ka nānā ʻana i nā maʻi maʻi hakahaka me kahi ʻano maʻi maʻamau o ka palaleka maʻi.

Nā hanana hewa

Ma ka hoʻoponopono ʻana i nā loiloi, ʻo ka hapa nui o nā maʻi maʻi āpau e hopohopo nei i ka dyspepsia, huhū hewa. Ma nā hoʻokolohua hōʻoia, ua ʻike ʻia ka hyperuricemia, kahi hōʻemi i ka maikaʻi o ka gland thyroid, a me ka leukocytosis.

Ma waena o nā hopena ʻē aʻe ʻole i ʻike ʻia (kahi pilina me ka incretin mimetic ʻaʻole i hoʻāʻo ʻia) - nā maʻi ʻeha, ʻoiʻi ka maʻi, migthine, nasopharyngitis). ʻO ka ulu ʻana o hypoglycemia e like me nā hopena i loko o ka hui hoʻokipa e loaʻa ana i ka placebo.

Nā hopena hoʻopuka lāʻau lapaʻau

Me ka hana o ka sitagliptin me ka metformin, rosiglitazone, contraceptives waha, glibenclamide, warfarin, simvastatin, ka pharmacokinetics o kēia ʻano o nā lāʻau i loli.

ʻO ka hoʻokele ʻana o sitagliptin me ka digoxin ʻaʻole ia e hoʻopiʻi i kahi loli i ka nui o nā lāʻau lapaʻau. Hāʻawi ʻia nā ʻano like ʻole e ka ʻōlelo aʻo a me ka hoʻopili ʻana o ka sitagliptin a me cyclosporin, ketoconazole.

Sildagliptin - hui kikowaena

ʻO Sitagliptin ka inoa honua no ka lāʻau lapaʻau, ʻo kona inoa kālepa ʻo Januvius. Hiki i kahi analogue ke manaʻo ʻia i ka lāʻau lapaʻau i hoʻohui ʻia ʻo Yanumet, aia kahi me ka sitagliptin a me ka metformin. No Galvus kekahi i ka hui o DPP-4 inhibitors (Novartis Pharma AG, Switzerland) me ka hui pū 'ana vildagliptin, kumukūʻai 800 rubles.

ʻO nā lāʻau Hypoglycemic kūpono hoʻi no ke code ATX o ka pae 4:

• Nesina (Takeda Pharmaceuticals, USA, e pili ana i ka alogliptin),
• Onglisa (ʻO Bristol-Myers Squibb Company, i hoʻokumu ʻia ma saxagliptin, kumukūʻai - 1800 rubles),
• Trazhenta (ʻO Bristol-Myers Squibb Company, ʻAmelika, Pelekane, me ka linagliptin mania ikaika), kumukūʻai - 1700 rubles.

ʻAʻole paʻa kēia mau lāʻau lapaʻau i loko o ka papa inoa o nā lāʻau lapaʻau kūikawā, mea pono paha ka hoʻokolohua ma kou pilikia ponoʻī a pākē me kāu kumukūʻai a me ke olakino?

Nā Manaʻo Sitagliptin

Ma ka hoʻopiʻi ʻana ma nā hōʻike e pili ana i nā kumuhana temala, ua helu pinepine ʻia ʻo Januvius i nā maʻi maʻi maʻi i ka manawa mua o ka maʻi. E pili ana i sitagliptin, nā hōʻike o nā kauka a me nā mea maʻi e hōʻike ana he nui nā nuances o ka hoʻohana ʻana i ka incretinomimetic.

ʻO Lavvia kahi lāʻau lapaʻau hou hou a ʻaʻole i loaʻa i nā kauka āpau ke loaʻa ka ʻike me ka hoʻohana. A hiki i kēia manawa, ʻo ka metformin ka laʻa mua loa; Inā lawa nā mea hiki, e hoʻohui pū iā ia me ka metformin a me nā lāʻau lapaʻau ʻē aʻe.

Hoʻopiʻi ka maʻi maʻi i ʻole e hālāwai ka lāʻau lapaʻau i nā koi i ʻōlelo ʻia i ka manawa, i ka manawa e emi ana kona pono. ʻAʻole ka pilikia ma ʻō ke hoʻohana pono i nā pālima, akā i nā hiʻohiʻona o nā maʻi: ʻo ka maʻi diabetes type 2 he ʻano maʻi, holomua holomua.

Ke pili nei nā ʻōlelo āpau i ka hoʻomaka ʻana o ka sitagliptin i loko o ka hana lapaʻau, ka mea e hōʻike nei i ka papa hou o nā lāʻau lapaʻau hou, e loaʻa ana i ka manawa kūpono no ka mālama ʻana i ka maʻi type 2 i kēlā me kēia manawa, mai prediabetes a me nā hopena hou, me nā hopena maikaʻi ʻole mai ka hoʻohana ʻana i nā kumu uku lapaʻau glycemic kūlohelohe.

Hoike a Profesor A.S. Ametov, endocrinologist-diabetesologist e pili ana i ka ʻatikala a me ka hana o ka hoʻohana ʻana i sitagliptin - ma ke wikiō.

Nā hōʻailona no ka hoʻohana ʻana

ʻO ka Sitagliptin kahi hana e hoʻopaʻa ai i nā kiʻekiʻe o ke kō, akā ʻaʻole ia no ka lāʻau no ka mālama ʻana. ʻO nā ʻōkuhi ma ka pharmacokinetics o sitagliptin he kūʻokoʻa o ka pae makahiki, ke kaumaha ma ke ahonui, a me ka manawa pāʻina. Hōʻalo ka lāʻau lapaʻau inā ʻai i nā meaʻai momona me ka ʻole o ka hoʻololi ʻana i kāna mau waiwai.

Ua hoʻokūʻē ʻo Sitagliptin iā ia iho he hoʻopili o ka maʻi maʻamau, ʻoiai ʻo ka hapa nui o nā mea maʻi me ka maʻi type 2 e loaʻa ana nā pilikia me ka meaʻai, a me ka hana o ka pono kino pilikino.

Hoʻomaʻawale ka Sitagliptin i ka momona, aʻo ka mālama ʻana i ka manaʻo mau loa o ka piha piha. He hopena maikaʻi kēia o nā poʻe maʻi me ka maʻi maʻi, e hōʻeha nei i ka nui o ka paona.

ʻO Renal hiki ʻole

ʻO nā keiki ke kuleana no ka hoʻoneʻe ʻana i ka lāʻau mai ke kino, no laila, me ka loaʻa ʻana o kahi hana maʻi ʻole loiloi, kahi nānā ʻokoʻa holoʻokoʻa o ka ʻōnaehana urinary ma kahi holoʻokoʻa. I kahi o kahi palapala mālie, ʻaʻole i loli ʻia ka hewa, me ke ʻano paʻaha i hoʻoponopono ʻia i 50 mg i kēlā me kēia lā.

ʻO ka hoʻohanohano ma ka maʻi maʻi - e inu wale i kēlā me kēia lā.

Inā hana ʻia ka dialysis, noʻonoʻo pono ʻia ka hoʻohana ʻana o Sitagliptin, e pili ana i ka paʻakikī o ke kiʻi o ka maʻi ma ka maʻi. Me ka hoʻohana hou o Sitagliptin, pono e nānā pinepine i ka helu ʻana o ka urine i ka piha.

Hoʻohana i ka wā kahiko

Wahi a nā haʻawina i nā ʻelemakule, ʻo ka ʻike ʻana o sitagliptin i ke koko he 20% kiʻekiʻe ma mua o ka hanauna ʻōpio. Eia nō naʻe, e like me nā hōʻike ʻana o ka hoʻoponopono ʻana, ʻaʻole pono ia, no ka mea i loko o ka hōʻiliʻili ʻoi ʻana ua hana maikaʻi ka lāʻau ma kēia pūʻulu o nā mea maʻi me ka maʻi maʻamau ʻo type.

E hui pū me nā lāʻau lapaʻau ʻē aʻe

Hoʻoponopono maikaʻi ʻo Sitagliptin, me ka ʻole o ka loli ʻana i ka lāʻau lapaʻau e like me nā:

• metformin
• warfarin
• simvastatin
• huiloli,
• piipili
• ketoconazole
• kāmakua
• nā mea hoʻohālikelike waha.

I kēia hihia, ʻaʻole pono ka lāʻau i ka hoʻoponopono hoʻoponopono.

Nā hopena hopena

Hoʻopili i nā pilikia o ka hoʻomohala ʻana i ka pancreatitis. Inā hele mai nā hōʻailona o kēia maʻi, kāpae i ka lawe ʻana i ka lāʻau. Ke lawe ʻia me ka sulfonylurea ma kahi kikoʻī, a hōʻemi nui ia i nā pae gula.

Ma nā maʻi maʻi 2 like ʻole, hiki i kahi mea hōʻeha kino ke ʻano ma hope o ka hoʻopuka ʻana o Sitagliptin i kahi mālama paʻakikī. Pono e kūkā koke i ke kauka inā:

• hōʻeha ma ke kua a me nā wāwae,
• loiloi a lōʻihi paha?
• nā hōʻailona puʻuwai o SARS a i ʻole ka palena o ka hanu,
• lie kanikela
• ʻaihue pancreatitis
• anaphylaxis me ka neurema edema,
• ka ʻeha a i ʻole hoʻi i ka ʻano i loko o ke ʻano o ka urticaria,
• mau wahi ʻulaʻula nui ma ka ʻili,
• pilikia kūlohelohe.

Ke keu

ʻAe ʻia ka overdose o sitagliptin. Inā kānalua nā wai o ka lāʻau lapaʻau a i ʻole he hopohopo (e kūpaʻa ana i nā mea maʻi maʻi), ʻoi aku ke kāhea koke aku nei.

Lawe ʻia nā mea kikoʻī āpau o Sitagliptin i kāna hana nui. I nā hoʻomākaukau e hoʻomohala ʻia, he kaulike ʻo Sitagliptin a me Metformin.ʻO ka papa i hōʻike i nā koho i loaʻa.

Ua kuhikuhi ke kauka i ka sitagliptin i hoʻohui ʻia me ka metformin. E like me nā kauoha no ka hoʻohana ʻana, ua hoʻopili hou ʻia nā kauā. Ma hope o ka heluhelu ʻana i ka loiloi nui, ua mākaukau wau no nā hopena ʻaoʻao, akā ua maikaʻi nō i hala iaʻu. Ua maikaʻi wau ma hope o ka hebedoma hoʻohana.

Nikolay, ke kūlanakauhale o Krasnoyarsk

ʻO Sitagliptin a me kāna mauʻikepili e hoʻomaʻamaʻa maikaʻi i koʻu kūlana. ʻO ka manawa mua ma hope o ke koho ʻia o ka papa i hōʻeha ʻia a me ka maʻi nausea, akā ma hope o ka hebedoma ua hoʻi hou nā mea a pau.

Hoʻopau mau nā maʻi maʻi i nā hoʻopiʻi kaumaha. Ka pilikia nui o ke kōkō koko.

Aronova S.M. hāʻawi i nā wehewehe e pili ana i ka mālama ʻana i ka maʻi maʻi. Heluhelu piha

Ka helu ʻana a me nā ʻenehana o ke hana

ʻO ka mea hana nui o ka lāʻau ka sitagliptin o ka inoa like. ʻO ka inoa Latin o ka lāʻau lapaʻau ʻo Sitagliptin. Me ke kūleʻa koko hoʻoneʻe a kiʻekiʻe paha, hoʻonui ka lāʻau lapaʻau i ka hana o ka insulin, ka hoʻoneʻe ʻia o ka hormone e nā cell beta i ka pancreas, ma muli o ka hopena i ka hana o ka hōʻailona ʻana i nā hana intracellular.

Ma hope o ka lawe ʻana i ka lāʻau lapaʻau, hele mai kahi wikiwiki. Hōʻike ʻia ka Sitagliptin e ka bioavailability kūpono loa - 87%. ʻO ka hoʻohana ʻana i nā meaʻai momona ʻaʻole i pili i ka pharmacokinetics o ka lāʻau.

Hoʻololi ʻia ka lāʻau lapaʻau i loko o ka pāʻai, a ma hope o ka hoʻopaʻa ʻana i ka mālama ʻana no hoʻokahi hebedoma, ʻo ia ʻo 87% me ka urine a me 13% me nā feces.

Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau

E like me nā kuhikuhi i ka hoʻohana ʻana, ua ʻōlelo ʻia ʻo Sitagliptin i mea lapaʻau no ka hoʻonohonoho ʻana o ka monotherapy no nā maʻi maʻi maʻi me ka ʻatikala o ke ʻano lua. Hiki hiki ke inu ʻia nā papa no nā meaʻai.

ʻO ka hui pūʻana o sitagliptin a me nā lāʻau lapaʻau me ka metformin e hiki nō hoʻi i nā maʻi maʻi o ka lua. Hana ʻia nā dosages me ka hana like me ka metformin - 100 mg hoʻokahi i ka lā.

Inā nalowale ʻia ka manawa o ka paila, a laila pono ʻoe e inu iā ia i ka wā hiki loa ʻia, ʻo ka mea ke pāpā ʻia i ka pālua ʻelua. Ua hoʻohālikelike ʻia nō hoʻi e inu i nā papa maʻamau ma mua o ka hōʻike ʻia e nā ʻōkuhi.

Mālama ʻo Sitagliptin i ke kō koko koko, akā hana ka hana i ka hoʻopau ʻana i nā hōʻailona o ka maʻi maʻi, a ʻaʻole hoʻi e kāpae i ka hopena o nā mea etiological ma ke kino.

Pono ia e lawe i nā pila ke pale pono i ke olakino maʻamau. E hoʻopau wale i ke papa e like me ka mea i kuhikuhi ʻia e ka loea.

Me ka monotherapy a i ʻole me ka hui ʻana ʻo "Sitagliptin" me kahi dosis o 100 mg i lawe mau ʻia, hoʻemi ʻia ka nui o nā maʻi no nā poʻe me ka hana ʻole ʻana.

ʻO ke ala nui o ka hoʻopauʻana i ka lāʻau ma ka excretion i loko o nā keiki. No ka poʻe maʻi me nā ʻano haʻahaʻa a me ka hoʻokaumaha ʻole o ka maikaʻi o ka renal, me ka hopena ʻole o ka maikaʻi ʻole o ka renal ka mea nui loa, he mea nui ia e hana i kahi hoʻoponopono - ʻo ia hoʻi, e hōʻemi i ka dosage. Ma kēia ala wale nō ke hiki ai i ka ʻike like ʻana o ka ʻohana neʻe i ka plasma e like me ka maʻi maʻi maʻa ʻole me ka hana ʻole ʻole o ka lua.

Loaʻa nā hopena maikaʻi loa

Ua hōʻike ʻia ua loaʻa ka hopena o ka hoʻomohala ʻana i ka hypoglycemia i nā poʻe maʻi e lawe i ke ala o Sitagliptin i hoʻonui. ʻAʻole i hana ʻia nā haʻawina e pili ana i ka lawelawe ʻana me nā lāʻau lapaʻau, kahi hopena o ka hopena me ka hypoglycemia.

ʻAʻole loli nā dosage no nā maʻi me ka hōʻemi ke hoʻololi ʻole i ke aʻa.

Hiki ke hoʻokaʻawale i nā hopena o ka lāʻau i loko o nā pūʻulu e pili ana i ka hopena ma luna o kekahi ʻōnaehana i ke kino.

• ʻeha ka ʻōpū
• huki iki o ka ʻōpū a me ka luaʻi,
• ʻumiina
• constipation
• he ʻano hūnā
• pancreatitis, hiki ke ulu i loko o nā ʻano mea momona.

• pili
• hakulua
• ʻili vasculitis
• angioedema.

ʻO nā hopena ʻē aʻe:

• nā maʻi ʻeha hanu kiʻekiʻe
• poʻomanaʻo
• aolaila
• myalgia
• ʻili ʻōlima
• ʻeha ke kaumaha
• paʻa inoa ʻole.

I ka hanana o ka lāʻau overdose, koi ʻia ke nānā ʻana i nā ʻāpana nui i ke kino. Ke lawe nei ke kauka i ka mālama maʻi hōʻailona, ​​kākoʻo ʻia nā hana kākoʻo, e komo pū ana me ka hemodialysis.

I ka lāʻau lapaʻau, ʻike ʻia nā hōʻeha e pili ana i ka hoʻomohala ʻana i ka maʻi pancreatitis ma muli o ka hopena maikaʻi i ka lāʻau. ʻO ka maʻamau maʻamau he ʻano hemorrhagic a necrotic paha, e hiki ai i ka make. Pono ke kanaka maʻi maʻi maʻi e pili ana i nā hōʻike ʻano hoʻohālikelike o ka hōʻeha ʻana i ka maʻi pancreatitis e koi koke i ke kōkua a i ʻole e hele i ka haukapila. ʻO kēia mau ka hōʻeha nui ʻole a me ka hōʻeha ʻana ma ka ʻōpū. Inā kānalua ʻoe i ka hōʻike o ka pancreatitis, hoʻopau koke ka lāʻau lapaʻau.

ʻO ka "Sitagliptin" hoʻohālikelike ʻia nā mea like me nā lāʻau lapaʻau:

ʻO ka analogue kaulana loa ʻo Yanumet. Ua kiʻekiʻe loa kona kumukūʻai, ma kahi o 2900 rubles.

ʻO Sitagliptin kahi hanauna hou o ka lāʻau lapaʻau. Akā ʻaʻole lawa nā kauka a pau i ka hana o kāna hoʻohana pono ʻana no nā maʻi maʻi 2 like ʻole. A hiki i kēia manawa nui, ʻo ke ʻano lāʻau lapaʻau nui loa no kēia maʻi ʻo Metformin, a ke ulu nei ka hiki ke hele mai me ka koho o ka monotherapy pono me Sitagliptin. Inā lawa ʻole nā ​​kaha o ka lāʻau lapaʻau e kāohi i ka pae o ke kō, ua hoʻohui ʻia ia me Metformin a i ʻole nā ​​lāʻau ʻē aʻe ma ka ʻono o ke kauka.

Wahi a nā loiloi a nā mea maʻi, ua hoʻokumu ʻia kahi manaʻo maikaʻi e pili ana i ka lāʻau lapaʻau. Hoʻopili nui ia i ke kao o ka glucose i loko o ke koko, hiki iā ʻoe ke hoʻopaʻa paʻa i ke kūlana e pale ai i ka hoʻomohala ʻana o nā hopena ʻaoʻao, e komo pū me nā hōʻeha hōʻeha o ka hypoglycemia.

Akā aia kekahi mau manaʻo e kaniʻi ai nā maʻi maʻi e pili ana i ka nele o ka hopena i haʻi ʻia i loko o nā kuhikuhi, a me kahi emi o ka hopena mai ka hoʻohanaʻana i ka lōʻihi o ka manawa. ʻO kēia ma muli o ka hōʻoia i ka lua o ke ʻano o ka maʻi maʻi i ka maʻi kūlohelohe o ka holomua.

Hiki iā ʻoe ke kūʻai i ka lāʻau ma ka mākeke Lūkini ma ke noi ʻana o kekahi kauka. ʻO ke kumu kumukūʻai mai 1500 - 1700 rubles.

Hoʻohālikelike

Ke kōkua nei ka hoʻohana ʻana o Sitagliptin endocrinologists i loko o ka hana lapaʻau e hoʻonui i nā mea e pili ana i ka mālama ʻana i ka maʻi type 2, e pili ana i ke ʻano o ka hoʻomohala ʻana. Ke hōʻike nei ka lāʻau lapaʻau i nā hopena maikaʻi i nā mea maʻi me ka prediabetes a no nā poʻe i kōkua ʻole ʻia ka hoʻoponopono ʻia ʻana e hiki ai ke hopena i ka hopena i manaʻo ʻia a hoʻomaikaʻi maikaʻi i ke olakino olakino.

Nosological ʻano papa (ICD-10)

Ka Hana Helu ʻĀina o nā maʻi o ka ʻumi ʻumi o ka Hoʻomihala (ICD-10) he pono hana loiloi ma ka pae o ka mālama mālama olakino, lāʻau lapaʻau, epidemiology, a me ka nānā ʻana i ke kūlana olakino olakino o ka lahui. Wahi a ICD-10, hiki ke hoʻohana ʻia ka lāʻau lapaʻau ma nā papa o Hoavia no nā maʻi e like me kēia.

• E11 Mellitus-non-diabetes diabetes mellitus (type 2 diabetes mellitus).

Nā mea kūʻai

ʻO nā mea kū aku iā Januvia:

• mikuleka
• sodium polio
• kalekaʻiʻawa pākūkū
• sodium stearyl fumarate,
• paʻahau magnesium.

• waiʻona polyvinyl
• ka leʻaleʻa talcum
• titanium hone
• ise kaomi lepo
• macrogol (polyethylene glycol) 3350,
• ʻulaʻula hao.

Nā ʻōkuhi no ka hoʻohana ʻana iā Januvia

ʻO ka heluhelu ʻana i kēia mau ʻōlelo aʻoaʻo no ka hoʻohana ʻana i ka lāʻau lapaʻau ʻO Januvia ʻaʻole i hoʻokaʻawale i ka mea maʻi mai ke aʻo ʻana i ka "Pale no ka hoʻohana ʻana iā Januvia", aia i loko o ka pale pepa kāpili mea hana.

Ua kuhikuhi ʻia ka lāʻau lapaʻau ʻo Pauvia e like me nā kauoha a nā poʻe maʻi me ka maʻi diabetes mellitus type 2, i kekahi mau hihia me ka metformin a i ʻole glitazones, ka hoʻāhu kino pilikino a me ka meaʻai. Hoʻohana ʻia ka lāʻau lapaʻau i ka mālama ʻana i ka pilikia a me ka hema ole o ka ate. Me ka piʻi o ka glucose koko, ka hopena o ka lāʻau lapaʻau e pale i ka huna ʻana o ka glucagon, e pale ana i ka hoʻomohala ʻana o ka hypoglycemia.

Hoʻokumu ka hana a Januvia i ka hana o ka insulin a me ka hana ʻana o nā pehu beta pancreatic.

ʻAʻole hoʻonui i ka paona kino o ka mea maʻi i ka wā e lawe ai i ka lāʻau lapaʻau.

Wahi a nā ʻōlelo kuhikuhi, ua hoʻoholo ʻia ke ala o ka mālama ʻana a me ka helu ʻana o nā papa e ka neʻe ʻana i ka endocrinologist. Ua kuhikuhi ʻia ko Diabetics ʻo Pauvia 100 mg hoʻokahi i ka lā. In renal gagal, hoʻoneʻe ke ʻano o kēlā me kēia lā i 50 a 25 mg paha, e pili ana i ka nui o ka maʻi. Inā hele ʻoe i ka ʻikepili ma hope, ʻaʻole pono ʻoe e hoʻonui i ka nui o ka helu o Januvia.

Pono e mālama ʻo Iāvia i kahi wahi pouli a i ʻole hiki i ka hiki o nā keiki ke ana ma kahi mahana ʻaʻole he 30 ° C.

ʻO ka nohona pili ola he 24 mau mahina mai ka lā i hoʻokuʻu ʻia ai ka lāʻau lapaʻau. Ma hope o ka lā hoʻopau kau i hōʻike ʻia ma ka pōkā - mai hoʻohana.

Loaʻa nā ʻaoʻao ʻaoʻao o Januvia

Ua hoʻomanawanui nui ʻia ʻo Januvia me ka ʻole e hoʻopuka i nā hopena ʻaoʻao. I nā hanana kūʻokoʻa loa, hiki mai nā hanana ʻē aʻe.

Mai ka papa hana hanu:

• ʻO nā maʻi ʻeha
• Nasopharyngitis.

Mai ka pūnaehana neʻe waena:

Mai ka pūnaehana hana ʻana:

Mai ka ʻōnaehana musculoskeletal:

Mai ka hoʻonā endocrine:

Nā Kaukaʻi ʻOvivius

Nā maʻi hoʻohālikelike i ka hoʻohana ʻia ʻana o ka lāʻau lapaʻau ʻO Jasonvia:

• maʻi diabetes type 1
• hapai
• maʻi maʻamau ketoacidosis,
• lactation wā
• ka hopena paʻakikī loa i nā mea o ka lāʻau.

ʻAʻole i aʻo ʻia ka hopena o ka lāʻau o ka oā ʻoviavia no nā mea maʻi ma lalo o ka makahiki 18; ʻaʻole i kuhikuhi ʻia nā papa o Nāvia no kēia ʻōpala.

Kaukau Januvius

ʻAʻole ke kumukūʻai o Januvius i loko o nā papa i ke kumukūʻai o ka lawe ʻana inā inā kūʻai ʻia ka lāʻau lapaʻau ma o kahi lāʻau lapaʻau pūnaewele. Hiki i nā kumu kūʻai ke hoʻololi nui i ka wahi kūʻai a me ka helu ʻana.

• Lūkia (Moscow, St. Petersburg) mai 2080 a 3110 ʻO nā rubles Lūkini,
• Ukraine (Kiev, Kharkov) mai 686 a 1026 Ukrainian hryvnias,
• Kazakhstan (Almaty, Temirtau) mai 9797 a 14648 Kazakhstani tenge,
• Belarus (Minsk, Gomel) mai 547040 a 817930 Belarusian rubles,
• ʻO Moldova (Chisinau) mai 582 a 871 ʻO Moldovan Lei,
• Kyrgyzstan (Bishkek, Osh) mai 2267 a 3390 Kyrgyz soms,
• ʻUzbekistan (Tashkent, Samarkand) mai 80662 a 120606 mau mea kuikohu Uzbek,
• Azerbaijan (Baku, Ganja) mai 31.0 a 46.3 manatsjani manats,
• ʻAmelika (Yerevan, Gyumri) mai 14290 a 21366 mau pahu Armenian,
• Keia (Tbilisi, Batumi) mai 70.7 a 105.7 ʻO Georgian lari,
• Tajikistan (Dushanbe, Khujand) mai 195.9 a 293.0 Tajik somoni,
• ʻO Turkmenistan (Ashgabat, Turkmenabat) mai 100.5 a 150.2 mau kanaka Turkmen hou.

Buy Januvius

Hiki iā ʻoe ke kūʻai iā Januvia i ke ʻano o nā papa kiʻi ʻoniʻoni i loko o kahi lāʻau lapaʻau e hoʻohana ana i ka lawelawe mālama lāʻau lapaʻau, e komo pū ai. Ma mua o kou kūʻai ʻana i hoʻomaʻamaʻa ʻia ʻo Januvius i ka lā pau. Hiki i ke kauoha iā Januvia me ka hoʻouna ʻana i loko o ka hale kūʻai pūnaewele. Hoʻokuʻu wale ʻia ka lāʻau lapaʻau ma o ka lāʻau lapaʻau.

Kaomi a kaʻana iā ʻoe ma kāu mau hoaaloha:

Mea hana ʻO Januvius

ʻO ka mea hana o Januvius ʻo Merck Sharp & Dohme. ʻO Merck Sharp & Dohme kahi hana kūʻai ma lalo o kahi kūʻai lāʻau kūʻai lāʻau ʻAmelika ʻo Merck & Co e kūʻai aku i kāna mau huahana i ka honua holoʻokoʻa.

ʻO Yanumet kahi papa paʻi kiʻi ʻoniʻoni, aia kēlā me kēia 50 mg o ka sitagliptin, me 500, 800 a me 1000 mg o ka metformin, no laila ke māhele i ka lāʻau e like me ka hoʻomohala ʻana o ka metformin i ka hoʻopili o ka lāʻau. Hāʻawi ka mākeke pharmacological i nā ʻano hana i hoʻoiho ʻia:

• Nā papa lole Janumet 500 mg + 50 mg,
• Nā papa lāʻau Janumet 800 mg + 50 mg,
• Nā papa lole Janumet 1000 mg + 50 mg.

Hiki i kahi pahu ke hoʻokahi ʻia mai kahi pahu a ʻehiku mau pīpī. ʻEhā mau blister pākaha i nui ka noi. Aia i kēlā me kēia hola 14 papa. Hiki iā ʻoe ke mālama i kēia lāʻau lapaʻau no ʻelua mau makahiki ʻelua.

kuala wale.

ʻAʻole pono ʻo Janumet e hoʻohana i mua o nā mea i hōʻike ʻia:

• ka hoʻomaloka ʻole i kekahi o nā mea i hana ʻia i ka lāʻau (povidone, metformin, sitagliptin phosphate monohydrate, stearyl fumarate a me ka sodium lauryl sulfate),
• ka maʻi maʻi like type 1
• nā pilikia koʻikoʻi o nā maʻi like ʻole, a me kahi kūlana paʻa i ka wā o ka lawe ʻana i ka maʻi a ʻāʻī paha (dehydration), pili pono i ka hana o ke keiki,
• mea inu kūloko a i ʻole inu ka ʻemi.
• ka manawa o ka hapai (ka manawa o ke gestation, a me ka manawa o ka umauma), nā noiʻi radiological (pololei i hoʻokahi pule ma hope o ke kaʻina hana)
• ka hele ʻana o nā maʻi, ʻo ka mea pili me ka ʻōnaehana cardiovascular, e alakaʻi ana i ka pololi o ka pololi o nā kiko.

ʻO ka nānā koʻikoʻi i ka wā e lawe ai iā Yanumet e hāʻawi ʻia i nā poʻe kahiko. ʻOiaʻiʻo, ma ka manawa, ke emi nei ka hana o nā keiki, a he kānana ia o ke kino o ke kanaka. Me ka wā o ka makahiki, nā mea maikaʻi ʻole o ke kālā excretory, ʻo ia ka mea e lilo nui ai ka paʻakikī e wehe i nā mea i makemake ʻole ʻia a me nā ʻāpana i ke kino. I ke koho ʻana iā Yanumet i nā poʻe kahiko, pono e koho maikaʻi nā loea i ka nui o ka lāʻau, a me ke ʻano e mālama mau ana i ke ʻano o ka mea maʻi.

Ke pāpā ʻia nei ka lāʻau no nā keiki ma lalo o 18 makahiki o kona mau makahiki.

ʻO Yanumet, e like me nā lāʻau lapaʻau ʻē aʻe, he nui nā hopena e hiki ʻole ai ke hele ma ka mea maʻi ma o ka manawa a kokoke paha i ka lawe ʻana.Hoʻomaopopo loa ka lāʻau lapaʻau i ka nui o ka gastrointestinal tract, e hoʻolōʻihi i ka lawe nui ʻana (a hiki i ka anorexia), a me ka pūnaehana cardiovascular. ʻO ka hoʻonāukiuki ʻana o nā nīnika maʻamau o ka metabolism ʻaʻole i haʻalele ʻia, i ka hoʻohui, ʻike ʻia ka hopena kūlohelohe mua loa o ka ʻili - nā ʻano like ʻole a me ka ʻeha.

ʻO nā hopena aʻe ka hopena i kumu paha ma o ka lawe ʻana i kēia lāʻau lapaʻau.

• hōʻeha nui ka eha ma ke poʻo a i ʻole mau, akā ke neʻe nei ka hoʻoluʻu, hōʻemi ka hana a me ka hana ʻana o ke kino, ma kekahi mau mea a ke ʻano o ka hiamoe a me ka mauʻeha mau ka ʻike.
• ʻeha ka ʻāʻī, hiki i ke ʻano o ke kahu transectorant hōʻino ʻole, hōʻoki i nā ʻeha ma ka ʻōpū o ka ʻōpū, i hele pū ʻia e ka maʻi, ka luaʻi, ka lemaki a me ka constipation, ka pupuhi o ke kino, ka nui ma luna o nā wāwae a me nā lima.
• ka moa maloʻo mau loa, ʻoiai ma hope o ka lawe ʻana i ka wai (ʻoi aku ka ukali pinepine ʻia e ka umukū), me ka hoʻohana ʻana i ka manawa lōʻihi, aia nā pilikia i ka hana o ka ʻōnaehana gastrointestinal.

Inā i ʻike ʻia kekahi o kēia mau ʻōuli a ke lawe nei i nā pil, e hōʻike koke ʻoe i nā kolohe i kāu kauka. Kahi e pili ana i ka nānā ʻana a me ke ʻano loiloi, hiki i kahi mea loea ke koho i ke ʻano kūpono no ka maʻi kūikawā. Ma kēlā me kēia, ʻaʻole ʻo Yanumet wale nō ka lāʻau lapaʻau e hiki ke kōkua iā ʻoe i ka hakakā ʻana i ka maʻi.

He lāʻau lapaʻau nui loa ʻo Janumet, ʻo ke kumukūʻai o kēlā me kēia 2700 a 3000 tausani mau rubles no ka hoʻopiha me nā blisters ʻehā. Pēlā nō, ʻano loli paha ke kumukūʻai ma muli o ke ʻano o ka hoʻokuʻu o ka huahana i kūʻai ʻia (helu helu o nā papa, ʻona metformin) a me kahi o ke kūʻai ʻana. No laila, ma nā hale kūʻai pūnaewele alakaʻi alakaʻi, ke kumukūʻai o ka pahu o Yanumet mai 2700 a 2800 rubles e kāpae i ka lawe (no nā papa 56. Akā i loko o nā lāʻau lapaʻau pūnaewele no Yanumet hiki iā ʻoe ke hāʻawi aku i 3,000 mano rubles.

ʻO ka hui kūikawā e hoʻohui i nā metformin a me sitagliptin e hana i kēia lāʻau lapaʻau i ka ʻokoʻa ma ka mākeke pharmacological. Ma hope o nā mea a pau, kokoke ʻo Yanumet i ka lāʻau lapaʻau wale nō e hoʻohui i kēia mau mea ʻelua. Akā, ke kumukūʻai ʻoi paha kahi e uku ai mākou i nā mea pili no ke ʻano maikaʻi, akā kūʻai ʻia hoʻi.

He like me ka ʻōmaʻomaʻo Velmetia, akā he like ʻole ke kumukūʻai o ia lāʻau lapaʻau mai ka kumukūʻai o Yanumet. ʻAʻohe mea lāʻau i ka kumukūʻai o ke kumukūʻai e pili ana i ke kino o nā mea maʻi me ka maʻi āpau ʻo 2 e like me Yanumet, akā hiki iā ʻoe ke hoʻāʻo e lawe i nā lāʻau lapaʻau hou e hoʻokō ai i ka hopena maikaʻi loa i ka mālama ʻana i ke kōpaʻa koko.

Ke komo nei kēia mau lāʻau:

• Metformin kūlohelohe (metformin) a me sitagliptin (Januvia). Uila ʻo Metformin ma kahi o 250 mau rubles no 60 mau ʻāpana, a ʻo Januvius 1500 no 28 mau papa. Pono e lawe ʻia kēia mau kālā e hoʻokō i ka hopena maikaʻi loa.
• ʻO Galvus (800 rubles no nā papa he 28) a me Glyukofazh (350 rubles no 60 papa) ma ka huina. Hoʻopau like kēia mau lāʻau i kēlā me kēia i kekahi, akā ʻokoʻa loa mai Yanumet i ko lākou nānā nui ʻana i ka hoʻopau ʻana i nā pilikia e pili ana i ka ʻōnaehana cardiovascular ma nā ʻano maʻi diabetes 2,
• ʻO Glibomet. Aia kēia lāʻau lapaʻa ka metformin a me glibenclamide a he like nō nā hōʻailona like me Janumet. Hoʻokumu ʻia ia e hakakā i ka hypoglycemia, nona nā lipid-hoʻemi haʻahaʻa. I ka awelika, ʻo ka uku o ia lāʻau lapaʻau he 350 rubles no 40 papa,
• Loaʻa pinepine ʻia ʻo Avandamet ma nā lāʻau lapaʻau Lūkini; ʻo kona kumukūʻai ʻehā he 400 mau rubles ma 60 papa. Loaʻa iā 500 mg o ka metformin a ʻaʻole hiki ke lilo ma ke ʻano kūpono no ka ʻoihana paʻakikī. ʻO ia ke kumu i hōʻemi loa ai kēia lāʻau iā Yanumet, ʻoiai ke hana maikaʻi nei me ka hoʻōla paʻakikī,
• Hōʻike ka Tripride i ka like me Yanumet, akā i ka haʻahaʻa o ka ʻike o nā mea i loaʻa i loko o ia mea (he glimepiride a me nā pioglitazone). Kēia huina o ia kumukūʻai e pili ana i ʻelua haneri mau rubles i kēlā me kēia kumukūʻai (30 mau papa) a ʻo ke ʻano he mea hoʻohālike i nā hōʻike āpau i hōʻike ʻia,
• Hoʻohui ʻo Douglimax i ka metformin a me ka glimepiride, a he mau like like me kahi o ka hana me nā papa kumu, akā ʻoi ka nui o ke kahe o ke kōhi koko me ka haʻahaʻa ma mua o lākou. E uku ʻo Douglimax e pili ana i 350 rubles no kahi pākana i loaʻa iā 30 mau papa.

ʻO ka mea nui e hoʻomanaʻo ai, ʻo ia kekahi mea e hoʻokaʻawale i kekahi lāʻau lapaʻau me kekahi e pono e ʻae ʻia me ke kauka, inā ʻaʻole hiki iā ia ke ʻae i nā hopena hiki ʻole. ʻAʻole hiki ke ʻae ʻia ka kūʻokoʻa i ka mālama ʻana i ia ʻano maʻi like ʻole, no ka mea hiki i kēia ke alakaʻi i ka palupalu i ke kūlana maʻamau a me kahi hāʻule ʻana i ke pae o ka glucose i loko o ke koko.

ʻO ka hiʻohiʻona a me nā ʻano waiwai o ka lāʻau lapaʻau

ʻO ka lāʻau lapaʻau o Iovia ka mea nui o ka hoʻōla ikaika - sitagliptin phosphate monohydrate. Hoʻohana ʻia ka lāʻau lapaʻau me ka hoʻohana ʻana o nā mea hoʻonani:

1. ʻO ka sodium Croscarmellose
2. ?
3. MCC
4. Sodium silyl mauʻuoh.

ʻO nā papa wai hoʻomālamalama i nā papa ʻoniʻoni i hana ʻia mai ka titanium dioxide, ka pakanikena mea hao i loko o ka wai male, polyvinyl alika waʻa oxide red, talc, macrogol.

ʻO Januvia kahi lāʻau lapaʻau maʻi haʻahaʻa haʻahaʻa, kahi mea koho selektif maikaʻi loa o ka enzyme peptidase dipeptidyl. Ma hope o ka lawe ʻana i ka lāʻau lapaʻau, ʻike ʻia kahi piʻi o ka neʻe ʻana o ʻelua mau huaʻai o nā huaole. Mahalo i ka lāʻau lapaʻau, aia kahi mea huna o nā hormones i loko o nā puʻuwai, he hoʻonui i kā lākou hana i ka wā o ka pāʻina. ʻO ka hana a nā hormone neʻe i ka synthesizing o ka hana ʻana i ka insulin.