ʻO Glucovans kahi lāʻau lapaʻau hypoglycemic hui pū ʻia, i hana ʻia ma ke kumu o ka metformin a me nā glibenclamide.

E like me ka ʻike ʻia, pili ka metformin i ka hui o biguanides. Kōkua kāna hoʻohana ʻana e hoʻemi i ka ʻikikūaʻai i ka ʻike. pili koko. ^ E Ha yM. I kēia hihia, ʻaʻohe hoʻoikaika o ka hilo insulinnolaila, aole ulu hypoglycemia.

Ma keʻano holoʻokoʻa, 3 mau hiʻohiʻona o ke ʻano he ʻano o ka metformin, ʻo ia hoʻi:

• ʻO ka hoʻohaʻahaʻa ʻana i ka hana glucose e ka ʻāhai e ka pale ʻana i ka glycogenolysis a me ka gluconeogenesis,
• peripheral receptor insulin sensitivity, hoʻonui i ka glucose a me ka hoʻohana ʻana i nā pūpū o nā uaua,
• lohi i ka hoʻokaʻina ʻana o nā glucose i ka pāwili ʻana.

Eia kekahi, ʻo ka lāʻau lapaʻau ka hopena maikaʻi o ka hoʻokumu kokohoʻemi haʻahaʻa kolamulaina triglyceridesa pela aku.

ʻO Glibenclamide, kahi derobe o ka sulfonylurea, hiki iā ia ke hoʻohaʻahaʻa i ka glucose ma o ka hoʻoulu ʻana i ka ʻimi waha o ka insulin e nā β-cells i ka pancreas.

ʻOiai ke ʻano me ka metformin a me glibenclamide e nā ʻano hana like ʻole o ka hana, e hoʻopiha nei i kēlā me kēia hopena hypoglycemic kekahi. I ka hui pū ʻana, hōʻike nā mea hoʻonaninani i ka hana synergistic i ka hōʻemi ʻana i nā mea o kekuhi.

Me ka hoʻokololi kūloko o ka glibenclamide, ʻo kona komo ʻana ma ka pā gastrointestinal ma kahi o 95%. Hoʻopiʻi kēia mea. Loaʻa ka hoʻokō nui o ka ʻai ka nui i loko o nā plasma i loko o nā hola 4. ʻO ka pilina o ka protein plasma e kūpono me ka 99%. Ke hopena hoʻokūkū 2 hoʻolālā ʻia i ka ate ʻole hoʻonaneaua hoʻopā ʻia e nā ʻili a me ka bile.

Hoʻohālikelike ʻia ka Metformin e ka hoʻopihapiha piha ʻana mai ka gastrointestinal tract, me ka hōʻea ʻana i ka nui o ka piʻi ʻana ma hope o nā hola 2.5. ʻO ka waiwai i hana ʻino ʻia. I ka manawa like, ua loli ʻole kona ʻāpana me ke kōkua o nā keiki.

ʻO ka hui pū ʻana o ka metformin a me glibenclamide like me ka bioavailability like me nā mea kūʻokoʻa. ʻAʻole make ka ʻai i ka bioavailability o ka metformin, akā e hoʻonui i ka nui o ke kao o ka glibenclamide.

Nā hōʻailona no ka hoʻohana ʻana

ʻO ka hōʻailona no ka lawe ʻana i nā pōpoki diabetes type 2 i nā maʻi maʻi makua:

• me ka maikaʻi ʻole mea ʻai, nā hoʻomaʻamaʻa kino a me ka hoʻōla ʻana me ka metformin,
• i mea e hoʻohuli ai i ka mālama mua ʻana no nā poʻe maʻi e mālama ʻia ana ka nui o ka glycemia.

Nā Hoʻohui

ʻAʻole kuhikuhi ʻia ka lāʻau lapaʻau no:

• ka makaukau ai me kana a me kana mea i,
• diabetes type II
• nā mālamalama maikaʻi ʻole a me nā maʻi lohi,
• maʻi ketoacidosis maʻi, precoma koma
• nā hopena ākea e alakaʻi ai i nā loli i ka hana o ka keiki: ke kaumaha, nā maʻi ākea, nā haʻalulu a pēlā aku.
• nā maʻiʻeha a me nā maʻi paʻa paha i hele pū ʻia me ka maʻi hypoxia: naʻau a i ʻole ka hanu ʻana, ma mua myocardial infarctionkāʻā haʻalulu
• ʻōpio
• pūpū hema
• porphyria
• lactation, hapai,
• hoopukui nui
• ka ʻalo ʻana i ka wai palaka a i ʻole ke kala ʻana i ka wai hoʻohālikelike,
• lactic acidosis,
• piliʻole i kahi meaʻai hypocaloric.

Eia kekahi, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau no nā mea maʻi ma mua o 60 mau makahiki, nā kānaka e hana nui ana a loaʻa nā maʻi hoʻoilina maʻamau loaʻa e pili ana me ka galactose intolerance, glucose-galactose malabsorption syndrome a me ka nele o ka lactase.

Pono e mālama ʻia i ka mālama ʻana i nā poʻe maʻi me ka febrile syndrome, ka adrenal insufficiency, hypofunction o ka aniani pituitary gland, maʻi thyroid, a me nā maʻi ʻē aʻe.

Nā hopena hopena

Ke hoʻomaʻamaʻa ʻia me Glucovans, pili pinepine nā hopena ʻaoʻao i nā ʻāpana āpau a me nā ʻōnaehana o ke kino.

Hiki ke hoʻohui ʻia i nā maʻi a me ka hoʻokūkū me ka hypoglycemia, ka hoʻouka ʻana o ka hepatic a i ʻole cutaneous porphyria, lactic acidosis, a pēlā aku.

Hiki i ke ʻōlohelohe a me ka lymphatic ʻōnaehana leukopenia, thrombocytopenia, agranulocytosisi ka mea pinepine ma hope o ka wehe ʻana i ka lāʻau.

ʻO ka hopena ʻaoʻao e hoʻopiʻi i ka hana o nā ʻōnaehana o ka nīnaʻe kahi luhi i ka ʻono. Nā iʻa ʻole ʻia i nā hana o nā lālā o ka ʻike, gastrointestinal tract, ʻili a me nā kiko o ka subcutaneous.

Nā maʻi immunological, nā maʻi hepatobiliary a me nā loli i loko o nā ʻōnaehana laboratory, no ka laʻana, he nui o ka neʻe ʻana, hiki i kekahi mau mea ke kū i kekahi manawa urea Mea Hanahoʻomohalahyponatremia.

Nā ʻōkuhi no ka hoʻohana ʻana o Glucovans (Ke ʻano a me ka helu ʻana)

Kuhi ʻia kēia pila hypoglycemic no ka hoʻokō waha. Ma kēia hihia, e hōʻike ana ke aʻo no ka hoʻohana ʻana o Glucovans i hoʻoholo ʻia ka nui o ka lāʻau no kēlā me kēia hihia kūikawā a hilinaʻi ʻia ma ke pae o ka glycemia.

E hoʻomaka i ka mālama ʻana me kahi papa hoʻokahi no ka hoʻokahi kala. I mea e pale ai i ka hoʻomohala ʻana o ka hypoglycemia, pono ia e ʻaʻole e hoʻonui ka nui o ka hopena ma mua o nā lā aku o ka glibenclamide a metformin i kēlā me kēia lā. No laila, hiki iā ʻoe ke hoʻonui i ka maʻa wale ma ka 5 mg + 500 mg i kēlā me kēia lā i kēlā me 2 mau heʻe aʻe paha hebedoma. Hāʻawi kēia ala iā ʻoe e hoʻokō i nā mākau kūpono o nā pae glucose koko.

E hoʻololi i ka mālama ʻana i ka hoʻomaʻamaʻa ʻana me ka metformin a me glibenclamide, hoʻonohonoho ʻia ke ʻano hoʻohālikelike e like me ka pauku. ʻO kēlā me kēia 2 a i hoʻokahi mau pule paha mai ka hoʻomaka ʻana o ka hoʻōla, hiki ke hoʻoponopono ʻia kahi hāmeʻe ma muli o ke kiʻekiʻe o ka glycemia.

I kēia hihia, ʻo ka nui loa o ka nui o ka lā ma 4 mau papa he Glucovans 5 + 500 mg a 6 paha i ka 2,5 + 500 mg. Kau ka hopena o ka hopena therapeutic i ke kuhi kū hoʻokahi o ka loea.

Pono e lawe ʻia nā papa liʻiliʻi me ka meaʻai. He mea nui ia o kēlā me kēia hoʻohana lāʻau i ka ukali me ka hoʻohana ʻana o nā meaʻai i kiʻekiʻe i nā haʻalulu, e kōkua ana i ka pale ʻana i ka hoʻomaka ʻana o hypoglycemia.

Ke keu

I nā hihia o ka overdose, ulu ka hypoglycemia. No nā hanana maʻalahi, hiki ke hoʻokō ʻia ka normalization ma o kaʻai koke ʻana i ke kō. Akā wikiwiki ʻoe nō hoʻi e hoʻoponopono i ka hapa a me ka meaʻai.

ʻO ka hopena hypoglycemic hopena, i hele pū me ka coma, paroxysm, kekahi mau pilikia neurological, koi pono i ka mālama maʻi.

Hoʻolako ka hana koʻikoʻi ma ke kau ʻana i kahi hopena i loko o kahi vein. Dextrosea me kekahi ʻālana lele hoʻokūkū. Ke hoʻihoʻi ʻia ka naʻau, pono e hānai i ka mea maʻi i ka momona momona a hoʻokaʻawale ʻia, nā mea e pale aku ai i ka hoʻomohala ʻana o ka hypoglycemia.

Eia kekahi, ʻo ka hoʻomohalaʻana o ka acidosis lactic, ke mālama ʻia nei e hana i loko o ka haukapila, ʻaʻole i haʻalele ʻia. ʻO ka lāʻau lapaʻau e kōkua ana e wehe i ke metformin a me ka lactate hemodialysis.

Hoʻohui

ʻO ka lawe ʻana i kēia lāʻau lapaʻau ʻO Miconazole paha kumu i ka hoʻolālā ʻana o ka hypoglycemia ma muli o ka loaʻa o ka glibenclamide i loko. ʻAʻole ʻae ʻia ka hoʻohana ʻoliʻoli me nā iodine e loaʻa i nā mea ʻokoʻa.

Phenylbutazone hiki ke hoʻonui i ka hopena hypoglycemic o ka lāʻau. ʻO kahi hui me ʻEntlelo.

I ka wā e hoʻohana ai i kēia pono hana, e hōʻike ʻia e mālama me ka akahele Chlorpromazine, Hanaa, Danazole,on2-adrenergic agonists, diuretics, kekahi mau mea hoʻokele ACE e hiki ke hoʻololi i ka ʻike o ka glucose i ke koko a lilo i ka hoʻomohala ʻana o nā hopena i makemake ʻole ʻia. No laila, lawe i kekahi lāʻau lapaʻau e koi i ke kūkā ʻana no ke loiloi.

ʻO nā mea hoʻohālikelike Glucovans

ʻO nā mea nui:ʻO Glybomet, Glucofast, Metformin a Siofor.

ʻO ka hoʻohana like ʻana i ka waiʻona e hiki ke alakaʻi i ka hoʻomohala ʻana i ka waihā lactic, e hiki ai ke hoʻonui me ka hoʻohuʻā ʻana i nā waiʻona ʻona. Hoʻopilikia ʻia ke kūlana e ka pōloli a i ʻole nā ​​meaʻai pono ʻole, a me ka hoʻopiʻi ʻana o ka ate. Eia kekahi, ʻo ka palaka pinepine pinepine i ka hypoglycemia. No laila, ʻo ka hoʻohana ʻana i ka wai ʻona a me nā huahana ʻē aʻe i loko o ka waiʻona pono e pono e haʻalele.

Nā Hōʻike Kūkulu

Loaʻa nā kūkākūkā ʻana o kēia pono hana ma nā ʻikepili e pili ana i ka maʻi maʻi. Hoʻomaʻamaʻa pinepine nā poʻe maʻi i kuhikuhi i kēia lāʻau lapaʻau i nā nīnau e pili ana i ke koho ʻana i ke kumumanaʻo a me ke ʻano, me ka hoʻohana pū ʻana me nā ʻano lāʻau like ʻole. Ma ka manawa like, ʻo nā loiloi e pili ana i ko Glucovans 5 + 500 mg a me 2.5 + 500 mg ka mea nui loa. ʻO ka maʻamau, no ka hoʻokō pono ʻana, pono ia e ʻike i ka nui o nā kaleka e hoʻopau ʻia e nā mea kākena a me ke ʻano o ke ʻano o nā lāʻau lapaʻau.

Eia naʻe, i kekahi manawa aia nā loiloi e lawe ʻole i kēia lāʻau lapaʻau. No ka mea, aia i kekahi mau mea maʻi, aia ka hewa i ka pae o ke kō i loko o ke koko, ʻo ia hoʻi, ʻo hypoglycemia. Ua hōʻike kekahi mau maʻi ʻē aʻe, i mea e hoʻomaʻamaʻa i ko lākou olakino, pono lākou i ka hoʻoponopono lōʻihi a me ka hohonu o ko lākou ola a me ka hoʻoponopono regimen.

Eia nō naʻe, he mea koʻikoʻi nā lāʻau lapaʻau o kēia ʻano no ka hoʻomaʻamaʻa ʻana, me ka hoʻomaikaʻi ʻana i ka maikaʻi o ke ola o nā mea maʻi me ka maʻi maʻi. Hōʻike ʻia kahi maʻi maʻi e noi mau ka olakino a ka maʻi i ka mālama a me ka mālama kūikawā. Hiki wale kēia i nā hoʻomaʻamaʻa hoʻohui o ke kauka a me ka mea maʻi, ka mea e alakaʻi ai i ka hoʻomaikaʻi nui ʻana i ke kūlana.

Ka hoʻokūkū, ke kumu o ka hana a me nā hōʻike no ka hoʻohana

ʻO Glucovans kahi lāʻau lapaʻau e pili ana i nā metafin nui a me nā glibenclamide. No nā papa o ka hui pūnaʻi hypoglycemic i hoʻohui ʻia no ka hoʻohana ʻana ma ke ʻano he paʻakikī paʻakikī i nā poʻe me ka maʻi mellitus o ka lua (non-insulin-dependence type o nā maʻi). E hoʻokuʻu i nā puka - nā papa no ka hoʻokele waha. Aia i ka pahu i ka ʻelua a ʻehā paha, ʻo kēlā me kēia mahele he 10 a 15 mau papa. Mamuli o ka helu o nā papa i loko o ka pulu, e like ke kumukūʻai mai 280 a 400 rubles.

ʻO ke ʻano o ka hana o ka lāʻau lapaʻau e hiki ke wehewehe i nā huaʻōlelo maʻalahi: i ka wā e lawe ai me ka ʻai, e kōkua i ka hoʻolalelale a komo i ka hoʻokaʻawale o nā kalama, ma muli o ka makemake i ke ʻano o ka nui o nā hormones i ke koko e hiki ke hōʻalo. Hoʻokomo ka hana nui o ka lāʻau metformin i loko o ka lāʻau lapaʻau o ka biguanides, e like me ka mea i ʻike ʻia e nā ʻōkuhi no ka hoʻohana. Kūkulu nā analogue Glucovans ma muli o ka waiwai like. No laila, e noʻonoʻo pono i ka hoʻokolohua me kāu koho no ʻoe iho i kahi lāʻau lapaʻau kūpono mai ka māhele kumukūʻai ʻoi aku ka maikaʻi, akā me nā mea like i ka mea hoʻokūkū.

No ka metformin (ʻo ia ka mea nui ka wai no ka nui o nā Glucovans analogues, ʻekolu mau hiʻohiʻona o ka ʻike i ke kino i nā ʻano.

• kaomi ʻana i ka hana glucose glucose ma ka pale ʻana i ka glycogenolysis a me ka gluconeogenesis,
• peripheral receptor insulin sensitivity, hoʻonui i ka glucose a me ka hoʻohana ʻana i nā pūpū o nā uaua,
• lohi i ka hoʻokaʻina ʻana o nā glucose i ka pāwili ʻana.

Ma muli o kēia hopena paʻakikī, ua hōʻike ke lāʻau lapaʻau iā ia iho i ka mālama ʻana o ka maʻi mellitus type 2 - i ʻelua ʻoki kūleʻa a me ke ʻano kākoʻo (hiki ke ʻano like me nā lāʻau ʻē aʻe, nā huaora a me nā mea hoʻouluolaʻai ma hope o ka ʻae ʻia o ke ʻano o ka lāʻau e ka neʻe ʻana i ka endocrinologist).

ʻAno maʻi II a me ke ʻano 2

ʻO ka maʻi diabetes mellitus ka "maʻi" maoli maoli o ko mākou manawa. Hoʻokani ka Endocrinologists i kahi ala: i nā makahiki i hala iho nei, ua hele pinepine nā hihia o ka insulin-dependant type diabetes mellitus i waena o ka poʻe ʻōpio. Ma kahi paha o kanalima mau makahiki i hala, ua hōʻike ʻia kēia maʻi, me ke ʻano he kānāwai, i loko o ka poʻe (ʻoi aku ka nui o nā wahine) i ʻoi aku ma mua o 50 mau makahiki. ʻO ka hapa nui, ʻo nā kumu o kona hoʻomohala ʻana i ka ʻai maikaʻi ʻole i nā makahiki he nui, hoʻopōʻino ʻana i nā pancreas, nā hūʻehaʻeha a me ke kaumaha mau loa.

Hoʻomaopopo ia i ka hoʻohana ʻana i ka lāʻau lapaʻau inā ʻaʻole i loaʻa ka mea maʻi i ka insulin ma ka hoʻonā ʻana. ʻAʻole ia he mea ʻole ka hoʻopili ʻana o kahi mea me ka maʻi ʻaʻai i kahi meaʻai haʻahaʻa haʻahaʻa-liʻiliʻi a i ʻole, ka poʻe Glucovans 5500 a me nā analogue me ka nui o ka metformin i ka hui pū me ka hana maʻa mau e hiki ke hoʻokō i ka hoʻowalewale o nā haʻalū. ʻO kaʻoiaʻiʻo, ʻo ka lawe ʻana i nā lāʻau lapaʻau kekahi mea ʻole ia i ka laikini i ka ʻōlelo o ka meaʻai. ʻOiai ke kūpaʻa o ka lāʻau o ka lāʻau lapaʻau, pono pono ka mea maʻi i nā rula o ka meaʻai haʻahaʻa-carb. Eia nō naʻe, e hoʻomaʻamaʻa nā endocrinologists i kā lākou poʻe maʻi e hiki i nā mea hoʻohālike o Glucovans me ka metformin i ke ʻano hana i hiki ʻole ke hahai pono i ka ʻai, me ka makaʻu ʻole i ka hopena o ka maikaʻi o ka olakino a me nā loiloi ākea i ke kō. Akā, ʻaʻole hilinaʻi nui ma ka hopena o ka lāʻau lapaʻau - ʻo ka nui o nā huina i hoʻopau ʻia me ka meaʻai e hoʻemi ʻia i kekahi hihia.

Nā Contraindications a me ka helu ʻai ʻia

ʻO ka ʻōlelo aʻo no ka hoʻohana ʻana i nā hōʻike pili, aia hoʻi nā contraindications e pili ana no ka lawe ʻana i nā papa Glucovans:

• maʻi diabetes type 1
• pilikia ʻole a me nā hana ʻē aʻe o nā keiki (pono ke kūkākūkā nephrologist).
• hapai, lactation,
• hoʻōla hoʻōla mai hope o ka hana ʻana,
• nā waiʻona maʻi maʻamau, ʻo ka manawa hoʻemi i ka waiʻona,
• nā ka wai, kahi wā nui o nā maʻi lohi.
• ʻeha ka maʻi maʻi maʻi (hoʻokipa ʻia ma hope o ke kūkākūkā ʻana me kahi hepatologist).

ʻO nā Glucovans 500 a me nā mea hoʻohālike o kēia lāʻau lapaʻau e hoʻopili i ka make o nā haʻalulu, no laila, me ka pākahi hoʻokahi, hiki iā lākou ke hoʻonāukiuki i ka maʻi ma nā maʻi me nā maʻi a me nā keiki. He mea hiki ʻole ka lawelawe ʻana o ka lāʻau i ka mea kūlohelohe - ʻoiai ke kūʻai aku ia me ka ʻole ke kumukūʻai a hiki i ka mea ke kūʻai aku iā ia, pono ʻoe e hoʻomaʻamaʻa i nā ʻāpana kūwili i mua o ka lawe ʻana a pono e ʻōlelo me ka endocrinologist. ʻAʻole pinepine ka maʻalahi i ka ʻimi e kūpono i ka mea maʻi - hoʻokahi papa i kēlā me kēia lā i lawa kahi no kekahi, a ʻekolu hoʻi ʻaʻole pono i kekahi. Pākuʻi ʻia ka dosage maikaʻi loa ma nā hiʻohiʻona o ke kino - ka paona, ka wahine, ka makahiki, ka hopena o ke ʻano koko.

Kahi papa inoa o nā mea hoʻomohala e ke kumu o ka hana

Nā mea kākau a me nā mea e pili ana i ka lāʻau lapaʻau "Glucovans", aia nō i loaʻa ka metformin e like me ka mea nui ka hana:

• Hana Kelila
• Siofor
• Hopu,
• Glibomet,
• Makalei,
• Amaril M

Aia ke ʻano o kēia mau lāʻau āpau i ke ʻano o ka hana - ke hoʻemi nei lākou i ka lilo ʻana o nā hāmoli, no laila e hoʻomaka ka mea maʻi i ka ʻoluʻolu, ke makemake nei no ka hoʻohaʻahaʻa ʻana i nā hāmeʻa maʻalahi, e lilo ia i mea maʻalahi ma ka mālama ʻana i ka ʻai, a me nā hoʻoliʻu kō koko.

ʻO nā mea hoʻohālikelike maʻalahi o nā papa Glucovans ʻo Metformin. Eia nō naʻe, ma nā lāʻau lapaʻau he paʻakikī paʻakikī e loaʻa. ʻOiai inā loaʻa ia, makemake nui nā lāʻau lapaʻau e hoʻolei i nā kikowaena keu.

ʻO Galvus Met: nā ʻōlelo aʻoaʻo no ka hoʻohana a me nā loiloi ma ka hoʻohālike o Glucovans

ʻO ke kumukūʻai o ka lāʻau lapaʻau e pili ana i 1300 rubles i kēlā me kēia pā. He ʻoi aku ka uku o Galvus Met no ka mea, ʻo ka hoʻohui me ka metformin, hoʻopili pū ʻia ka vildagliptin. ʻO kēia mau māhele ʻelua hypoglycemic a he hopena ʻokoʻa. ʻO ka mea maʻamau, ʻo ka vildagliptin kahi dipeptidyl peptidase-4 inhibitor. Me ka metformin, hiki i kēia mea ke alakaʻi i ka hoʻonui lōʻihi ʻana i ka kaila glucose. ʻO ka hapa nui o nā mea maʻi me ka maʻi diabetes type 2 e pono wale nō e lawe i hoʻokahi papa i hoʻokahi lā, ʻoiai ʻo Glucovans e lawe pinepine ʻia i ka lā.

No laila, ua hoʻāpono ʻia ke kumukūʻai kiʻekiʻe: ma muli o ka hopena, ʻo ke ala ʻo Galvus Met e ʻoi aku ke hanana ma mua o ka hana a ka poʻe Glucovans. ʻO nā ʻikepili e pili ana i ka hāmeʻa "Galvus Met" ʻokoʻa. Ma muli o ke ʻano ikaika o ka hahai ʻana o ke kanaka i ka papaʻai. Kūpono ka hapanui o nā loiloi: nā maʻi e hoʻoluhi ma muli, no ka hoʻohana ʻana i ka lāʻau lapaʻau maʻamau, hiki iā lākou ke hoʻihoʻi i nā pae glucose koko maʻamau. ʻO ia, ka mea, i ka hapanui o nā hihia, e hoʻokiʻekiʻe, akā paʻa, ma muli o ka hopena o nā mea maʻi e ʻoliʻoli, maikaʻi a ʻaʻole e hopohopo ʻia mai ka maʻi ʻeha, ʻiloha a me nā hōʻike ʻē aʻe o ka maʻi.

ʻO ka wehewehe ʻana i ke ʻano dosis

Kāleka 2.5 mg +500 mg: nā kāpena biconvex i kālai ʻia, i uhi ʻia me ke kaʻi ʻoniʻoni o ke kala ʻulaʻula, me ke kahakaha o "2.5" ma ka ʻaoʻao hoʻokahi.

Kāleka 5 mg +500 mg: nā kāpena biconvex i kālai ʻia, i uhi ʻia me ka pale poni ʻoni, me kahi kālai "5" ma hoʻokahi ʻaoʻao.

Lapaʻau lāʻau

ʻO Glibenclamide. Ke hoʻokau ʻia, mālamaʻia mai ka gastrointestinal tract ma mua o 95%. ʻO Glibenclamide, kahi ʻāpana o ka lāʻau Glucovans ®, i micronized. C_max i loko o ka plasma ua hiki ma kahi o 4 mau hola, V_{e d} - e pili ana i 10 liters. ʻO ke kamaʻilio me nā protein plasma he 99%. ʻAno ua hoʻohālikelike maoli ia i loko o ke akea me ka hoʻokumu ʻana o ʻelua mau metabolites hana, a hoʻopiʻi ʻia e nā keiki (40%) a me ka bile (60%). T_1/2 - mai 4 a 11 mau hola

Metformin. Ma hope o ka lawelawe ʻana i ka waha, hoʻoneʻe ʻia mai ka digestive tract piha loa, C_max i ka plasma i loaʻa i loko o nā hola 2.5. Ma kahi o 20-30% o metformin e hoʻopiʻi ʻia ma o ka gastrointestinal tract i loko o ka ʻano loli ʻole. ʻO ka bioavailability kūpono mai 50 a 60%. Hoʻolaha koke ʻia ʻo Metformin i loko o nā pā, hoʻomaʻamaʻa ʻole ia i nā protein plasma. Hoʻomili ʻia ia i kahi pae palupalu loa a hoʻopā ʻia e nā keiki. T_1/2 he awelika o 6.5 mau hola. In case of impaired renal function, renal clearance emi, as the creatinine clearance, while T_1/2 mahuahua, e alakaʻi ana i ka hoʻonui i ke kahe o ka metformin i ka plasma koko.

ʻO ka hui pū ʻana o ka metformin a me glibenclamide ma ke ʻano ʻano like me ka bioavailability like me ka lawe ʻana i nā papa i loaʻa nā metformin a i ʻole glibenclamide i ka hoʻokaʻawale. ʻO ka bioavailability o ka metformin i hui pū me ka glibenclamide ʻaʻole i loaʻa i ka ʻai kai, me ka bioavailability o glibenclamide. Eia nō naʻe, piʻi ka nui o ka emi ʻana o ka glibenclamide me ka ʻaina meaʻai.

Nā hōʻailona o ka lāʻau Glukovans ®

Pākuʻi type 2 i nā pākeke:

- me ka loaʻa ʻole o ka hoʻoikaika kino o ka meaʻai, ka hoʻomaʻamaʻa a me ka lāʻau i mua me ka metformin a i ʻole ka hopena o ke olalona.

- e hoʻohuli i ka maʻi ma mua o nā lāʻau lapaʻau ʻelua (metformin a me kahi deralona sulfonylurea) i nā mea maʻi me ka pae kūpaʻa a mālama pono i ka glycemia.

ʻŌpū a me ka lactation

Hoʻopili ʻia ka hoʻohana ʻana o ka lāʻau i ka wā hāpai. Hoʻomaʻamaʻa ʻia ka mea maʻi i ka manawa o ka mālama ʻana me ka lāʻau lapaʻau Glucovans ® he mea pono ia e hōʻike i ke kauka e pili ana i ka hāpai ʻana a me ka hoʻomaka ʻana o ka hapai. Ke hoʻolālā nei i ka wā hapai, me ka mālama ʻana i ka wā hāpai i ka wā e lawe ai iā Glucovans ®, pono e kāpae ʻia ka lāʻau lapaʻau a hoʻonā ʻia i ka mālama ʻana i ka insulin.

Hoʻopili ke Glucovans ® i ka umauma umauma, no ka mea ʻaʻohe mea hōʻike i kona hiki ke hele i loko o ka waiū umauma.

Nā hopena hopena

Hiki ke hopena i nā hopena ʻokoʻa i ka wā o ka mālama ʻana me Glucovans ®: ʻO ka nui o nā hopena ʻalike o ka lāʻau lapaʻau e manaʻo ʻia e like me: pinepine pinepine - ≥1 / 10, pinepine - ≥1 / 100, gastrointestinal tract: pinepine pinepine - nausea, luaʻi, ke kuʻeha, ka ʻōpū a me ka nele ʻole o ka makemake. ʻOi aku ka maʻalahi o kēia mau maʻi ma ka hoʻomaka ʻana o ka mālama ʻana a ma ka hapa nui ke kau nei ma luna o lākou. I mea e pale ai i ka hoʻomohala ʻana o kēia mau ʻōkuhi, ua kūpono ʻia e lawe i ka lāʻau lapaʻau ma nā 2 a i ʻole nā ​​3 wai liʻiliʻi, ka hoʻolōʻihi hāhā i ka hopena o ka lāʻau lapaʻau e hoʻomaikaʻi i kona ʻokoʻa.

Ma ka ʻāpana o ka ʻili a me ka kiko. lai, kaka keokeo, e like me ka heha, urticaria, maculopapular rash, ʻehā loa, ʻili a me ka visceral allergic vasculitis, polymorphic erythema, exfoliative dermatitis, photosensitivity.

Nā pale maʻi: ākea loa - pīhoihoi anaphylactic. Hiki ke hele mai nā ʻano cross-hypersensitivity i sulfonamides a me kā lākou ʻano derivatives.

Nā maʻi he Hepatobiliary: loa loa - hōʻailona kīpē hana lima ʻole a hepatitis, koi ana i ka hoʻokuʻu ʻana o ka mālama ʻana.

Nā ʻōlelo kikoʻī

E kūlike i ka papaʻa o ka mālama ʻana me Glucovans ®, pono ia e kiaʻi pinepine i ka pae o ka glycemia ma kahi ʻōpū ʻole a ma hope o ka ʻai.

ʻO ka maʻi lactic acidosis kahi ʻokoʻa a koʻikoʻi akā (ʻo ka make ma ke ʻano he nui ke ʻano o ka mālama ʻana i ka hana ʻoi aku ka hoʻopiʻi) e hiki mai ana ma muli o ka hoʻopiʻi o ka metformin. ʻO nā hihia o ka acidosis lactic i nā mea maʻi i mālama ʻia me ka metformin i hana nui ʻia i nā mea maʻi me ka maʻi mellitus me nā hana ʻole o ka pilikia.

ʻO nā mea ʻē aʻe e pili ana i ka pilikia, pono e noʻonoʻo ʻia, e like me ka ka maʻi maʻi kīnā ʻole, ka ketosis, ka manawa lōʻihi, ka ʻai ʻawaʻawa ka nui, ka make ʻana o ka naʻau, a me kekahi ʻano e pili ana i ka hypoxia koʻikoʻi

Pono ʻoe e noʻonoʻo i ka hopena o ka acidact lactic acid me ke ʻano o nā hōʻailona nonspecific, e like me nā ʻili o ka naʻau, i hui pū ʻia e nā maʻi dyspeptic, ʻeha ʻeha a me nā malaise koʻikoʻi. I nā hihia koʻikoʻi, hiki ke hele mai ka acidotic shortness o ka hanu, hypoxia, hypothermia, a me ka coma.

He mau ʻōhua ʻai o ka diagnosty ʻo nā mea hoʻonaninani: nā haʻahaʻa pH koko haʻahaʻa, konsentrate lactate plasma ma luna o 5 mmol / l, hoʻonui anionic interval a me ka lactate / pyruvate ratio.

No ka mea ʻo Glucovans ® e pili ana i ka glibenclamide, lawe pū i ka lāʻau e hele pū me ka hopena o ka hypoglycemia i ka mea maʻi. ʻO ka weheʻana i ka wai hoʻōla o ka hopena ma hope o ka hoʻomaka ʻana o ka mālama ʻana ke pale i ka hanana o hypoglycemia. Hiki ke kuhikuhi ʻia kēia ʻano maʻi i kahi mea maʻi e pili ana i ka pāʻina maʻamau (me ka ʻaina kakahiaka). He mea nui ia ka ʻaʻa kalapika e hana pinepine ʻia, ʻoiai ka pilikia o ka ulu ʻana o ka hypoglycemia e hoʻonui me ka papaʻaina o ka wā i hala ai, ʻaʻole i ʻole a i ʻole ka pale i ka paʻakai kalaiwa. ʻO ka hoʻomohala ʻana o ka hypoglycemia ka mea maʻamau me ka pākuhi hypocaloric, ma hope o ka hana koʻikoʻi a lōʻihi paha, me ka waiʻona a i hui pū ʻia me nā mea hoʻohālike o ka hypoglycemic.

Ma muli o nā hopena uku e hiki mai ana e ka hypoglycemia, e lomo, me ka makaʻu, ka tachycardia, hypertension, palpitations, angina pectoris a me ka arrhythmia. ʻAno i hala paha nā hōʻailona hope inā neʻe lohi ka hypoglycemia, i ka hopena o ka neuropathy autonomic a i ʻole e lawe ana i ka β-blockers, clonidine, reserpine, guanethidine a sympathomimetics.

ʻO nā hōʻailona ʻē aʻe o ka hypoglycemia i loko o ka poʻe maʻi me ka maʻi maʻi hiki ke komo i ka hōʻeha, ka pōloli, ka nausea, ka luaʻi, ke kaumaha nui, ka hoʻohālikelike ʻana i ka hiamoe, ke ʻano haunaele, ka huhū, ka pīhoihoi, a me ka noʻonoʻo psychomotor, ke kaumaha, ka hilahila, ka wahaʻōlelo, ka blurred matakite, haʻalulu, ʻōpū a me ka paresthesia, dizziness, delirium, hoʻopiʻi, kānalua, ʻike ʻole, ʻike ʻole make, a me ka bradycardia.

ʻO ka mālama pono ʻana, ke koho ʻana i nā palena, a me nā ʻōlelo kūpono no ka mea maʻi he mea nui e hōʻemi i ka hopena o ka hypoglycemia. Inā mālama ka mea maʻi i ka hoʻoulu ʻana o ka hypoglycemia, ka mea i hōʻeha a pili paha i ka ʻike ʻole ʻana o nā ʻōpuhi, pono e noʻonoʻo ʻia ka mālama ʻana me nā mea maʻi hypoglycemic ʻē aʻe.

Hoʻokomo ka poʻe i ka hoʻomohala ʻana o ka hypoglycemia:

- ka hoʻohana like ʻole o ka waiʻona, keu i ka wā e hoʻokē ʻai ai lākou.

- hōʻole a (ʻole paha no nā poʻe maʻi maʻi) ka hiki ʻole o ka mea maʻi e launa me ke kauka a hahai i nā ʻōlelo hōʻike i kuhikuhi ʻia i loko o nā ʻōkuhi no ka hoʻohana ʻana;

- nā meaʻai maikaʻi, ke komo ʻana o ka meaʻai maʻamau, pololi a i ʻole ka loli i ka ʻai,

- kahi hemahema ma waena o ka hana pilikino a me nā kākia kalaiwa,

uhaiki pohihihi

- he overdose o ka lālani Glukovans ®,

- nā maʻi endocrine kūloko: pono i kūpaʻa o ka thyroid gland, pituitary gland a adrenal glands,

- ka hui pū ʻana o nā lāʻau ponoʻī.

ʻO ka laupili o Renal a me ka pohō

Hiki i nā Pharmacokinetics a me / a i ʻole nā ​​pharmacodynamics i loli i nā mea maʻi me ka maʻi hepatic a i ʻole ka hopena kino ʻole. Hiki ke hoʻonui ʻia ka hypoglycemia e loaʻa ana i kēlā mau maʻi, kahi e pono ai ke ʻano kūpono.

ʻO kahi Pūnaewele Glucose

Ma ka hopena o nā mea hana a i ʻole ke kumu o ka hoʻokaʻawale ʻana o ka maʻi maʻa, ua manaʻo ʻia e noʻonoʻo pono ka hoʻololi iki ʻana i ka maʻi insulin. ʻO nā hōʻailona o ka hyperglycemia ke hoʻoiho pinepine, ka make nui loa, ka maloʻo maloʻo.

ʻO 48 mau hola ma mua o ka lilo ʻana o ka hoʻomaʻamaʻa ʻana a i ʻole ka hōʻea ʻia ʻana o ka ʻenehana radiopaque iodine, i hoʻopau ʻia ka lāʻau Glucovans ®. Hoʻomaopopo ʻia ka mālama ʻia ʻana ma hope o 48 mau hola a aia wale nō ma hope o ka hana renal i loiloi ʻia a ʻike ʻia he ʻano maʻamau.

No ka mea, ua ʻoki ʻia ka metformin e nā keiki, ma mua o ka hoʻomaka ʻana i ka mālama ʻana a ma hope mau aku, pono ia e hoʻoholo i ka Cl Clininine a / a i loaʻa nā serum creatinine: ma ka liʻiliʻi he hoʻokahi i hoʻokahi makahiki i nā mea maʻi me ka hana o ka māla maʻamau, a me nā manawa 2 mau makahiki o ka makahiki ma nā maʻi maʻi, a me i nā mea maʻi me Cl Clanine ma VGN.

Hoʻomaopopo ʻia e mālama pono i nā hihia i kahi e hoʻōki ai ka hana o ke keiki, no ka laʻana, i ka poʻe maʻi maʻi a i ka hoʻomaka ʻana o ka lāʻau antihypertensive, diuretics a NSAIDs paha.

ʻO nā hana ʻē aʻe

Pono ka mea maʻi e hoʻomaopopo i ke kauka e pili ana i ke ʻano o kahi maʻi bronchopulmonary a i ʻole he maʻi ʻeha o nā genitourinary organitions.

Hoʻokomo i ka hiki ke alakaʻi i kahi kaʻa a hana pū me nā mīkini. Pono e ʻike ʻia nā mea maʻi e pili ana i ka hiki o ka hypoglycemia a nānā i nā hana mua i ka wā e holo a hana ana me nā hana e koi ai i ka piʻi nui o ka nānā a me ka wikiwiki o ka hopena psychomotor.

Mea hana

ʻAʻōlelo hōʻoia: 37, rue Saint-Romaine, 69379, LION SEDEX, 08, France.

Ka helu o ka pūnaewele hana: Center de Producion CEMOIS, 2, rue du Pressoir Ver, 45400, CEMOIS, Farani.

Pono e hoʻouna ʻia nā mea e pili ana i ka manaʻo a me nā ʻikepili e pili ana i nā hanana ʻino i ka address o LLC Merk: 115054, Moscow, ul. Kahi, 35.

Tel .: (495) 937-33-04, (495) 937-33-05.

Hoʻohui ʻia nā lāʻau Glucovans lāʻau hypoglycemic: kumukūʻai, nā mea a me nā kauoha no ka hoʻohana ʻana

ʻO Glucovans kahi lāʻau lapaʻau hypoglycemic hoʻohui.

Loaʻa ia no ka hoʻohana pilikino.

He hopena maikaʻi ka lāʻau lapaʻau i ka hoʻokumuʻana o lipid i ke koko, ma hope o ka noi, e hoʻohaʻahaʻa i ka nui o ka pae kolamu.

E hoʻokuʻu i ke ʻano

Hoʻopili ʻia nā papa Glucovans me kahi membrane like-film o ka hue wai ʻōmaʻomaʻo, he ʻano capsule-a (biconvex).

ʻO nā papa ʻaina Glucovans 500 mg

Ma kahi ʻaoʻao o kēlā me kēia papa ʻike ʻoe e ʻike i ke kahakaha "2.5" a i ʻole "5" (nā kiko o ka glibenclamide in mg i loko o hoʻokahi papa). Hoʻokahi i hoʻokahi pahu e 2 a me 4 mau papa. ʻO ka leka "M (pono no ka pale ʻana i ke kūloko) hōʻailona ʻia i ka pahu pahu pepa a me kahi palaki plastik.

ʻO ka wehewehe ʻana i ka lāʻau lapaʻau

Kūkākūkā - Hoʻohui ʻia i ka lāʻau hypoglycemic no ka hoʻohana waha.

ʻO Glucovans ® kahi hui pūpū o ʻelua mau loiloi hypoglycemic waha o nā ʻano lāʻau lapaʻau like ʻole: metformin a me glibenclamide.

Aia ʻo Metformin i ka hui o ka biguanides a hōʻemi i nā kiko o ka basal a me ka postprandial glucose i loko o ke koko koko. ʻAʻole ia e hoʻoikaika i ka metformin i ka huna ʻana i ka insulin a no laila ʻaʻole e kumu i ka hypoglycemia. He 3 mau hana i ka hana:

- hōʻemi ia ka hana o ka glucose i ka peka e ka pale ʻana i ka gluconeogenesis a me ka glycogenolysis,

- hoʻonui i ka ʻike o ka ʻoneka no nā peripheral i insulin, ka ʻai a me ka hoʻohana ʻana i ka maʻi glucose e nā ʻāpana i loko o nā uaua,

- ke kau nei i ke kahe o ka glucose mai ka pā.

Loaʻa iā ia kekahi hopena maikaʻi na ka lipid komposisyon o ke koko, e hoʻemi i ka pae o ka kolamu, ka LDL a me TG.

He hana like ka metformin me ka glibenclamide hana like, akā hoʻopiha pū kekahi i ka hana hypoglycemic a kekahi. ʻO ka hui pūʻana o nā ʻaihue hypoglycemic ʻelua he hopena synergistic ma ka hoʻemi ʻana i ka glucose.

Ua hōʻike ʻia e nā malihini he helu huina o kēlā me kēia lā