Latren Pentoxifylline

ʻO Latren kahi lāʻau lapaʻau e hoʻomaikaʻi i nā microcirculation a me nā mea rheological o ke koko. ʻO ka hana ikaika o ka hoʻomākaukau Latren he pentoxifylline, e pili ana i nā vasodilator peripheral o ka hui purine. Hoʻopau ʻo Latren i ka spasm o nā māʻule maʻa o nā kīʻaha koko, bronchi a me nā kino o loko. Mālama i ka lāʻau i ka phosphodiesterase, hoʻomaikaʻi i nā waiwai o ka rheological o ke koko a me ka microcirculation, kōkua i ka hoʻonui ʻana i nā kiko o ka cyclic 3,5-AMP i nā pakanui hoʻoweliweli a vascular a me nā platelets. I ka wa e hoʻohana ai iā Latren, aia ka nui o ka ʻikepili o ATP i nā ʻāpana koko ʻulaʻula a me ka nui o ka ikehu o ka nui o nā cell. Kōkua ʻo Latren e hoʻomaha i ka pulu manene o nā kahe koko, e hōʻemi i ka nui o ke kūleo o kēlā me ko nā koina koko (me ka nui o ka loli o ka nui o ka puʻuwai), a me ka hoʻonui ʻana i ka minuke a me ka nui o ke koko systolic.

Loaʻa iā Latren kahi hopena antianginal, ka mea i hoʻokō ʻia e ka hoʻomaha ʻana i nā io momona o nā arteri coronary.
Hoʻonui ka mea lapaʻau i ka saturation o ke koko, e hoʻonui ana i nā kīʻaha o nā pūpuna, hoʻāla i nā ʻōpū o ka hanu (diaphragm a me nā ʻono intercostal), hoʻonui i ka collateral (roundabout) ka puni koko a hoʻonui i ka nui o ke koko e kahe ana i nā kino a me nā kiko.
Loaʻa i ka Latren kahi hopena maikaʻi i ka hana bioelectric o ka nihi sentral o ke kūleʻa a me ke kōkua i ka hoʻonui i ka ATP i nā kiko o ka lolo.
Kuhi i nā waiwai o ka membrane o nā kōpela koko ʻula, hoʻonui ʻo Latren i kā lākou elasticity. Hoʻopilikia i nā platelet dissgregation a hōʻemi i ka nānāʻana i ke koko.

Ma muli o ka hoʻonui hoʻonui collateral, hoʻonui ʻia ka microcirculation koko ma nā wahi ischemic.
Me nā claudication intermittent (nā maʻi maʻamau o nā neʻe peripheral), hoʻolōʻihi ka pentoxifylline i ka mamao e hele ana, e hoʻokaʻawale i nā pōkole pōkole o nā ʻōpū o ke keiki a pale i ka ʻano o ke ʻeha ma ka hoʻomaha.
Hoʻoikaika nui ka lāʻau, hoʻopau i nā metabolites 5, e komo pū ana i nā mea lapaʻau. ʻO ka Pentoxifylline i hoʻopuka nui ʻia e nā keiki ma ke ʻano o ka metabolites. ʻO ka hapalua o ka ola o ka pentoxifylline a me nā metabolites kahi o 0.5-1,5 hola. ʻO ka heleʻana o kahi renal impaired a hepatic paha e alakaʻi i kahi hoʻonui i ka hapalua ola.

Nā hōʻailona no ka hoʻohana ʻana

ʻO ka lāʻau Latren e kauoha ʻia no nā pilikia o ka peka, peropheral neuropathy, claudication intermittent, maʻi a me nā maʻi a ka Raynaud, e hoʻopau ana i ka endarteritis.
Hoʻohana ʻia ka lāʻau Latren no ka hōʻino ʻana i ka trophic tissue.
Hiki ke kuhikuhi ʻia ka lāʻau lapaʻau i ka mālama kino ʻana i nā mea maʻi me nā maʻi varicose, post-thrombotic syndrome, gangrene, frostbite a me nā ʻeha trophic.

Latren i kuhikuhi ʻia no ka poʻe maʻi me ka ulia cerebrovascular, ischemic stroke, dyscirculatory encephalopathy, me ka cerebral arteriosclerosis, ka mea i hele pū me ka ʻeha, ka ʻeha, ka hiamoe a me nā hana hoʻomanaʻo.
Eia kekahi, ʻo Latren e hoʻohana i ka mālama ʻana i nā pilikia o ka lele i loko o ka choroid a me ka retina, a i nā loli degenerative me ka hōʻuluʻulu lohi ʻana i nā hopena a me ka hopena o ka vascular pathology o ka pūloko o loko.

Ke ʻano o ka noi

ʻO ka lāʻau Latren ka mea i manaʻo ʻia no ka hoʻokele intravenous. Hoʻonohonoho ʻia ka nui ma ke kauka hoʻokahi a helu ʻia ʻo ia i ka paona ʻana o ke kino o ke kanaka, ke kaumaha o ke kaʻe, ka maʻi o ka maʻi a me ke ahonui i ka lāʻau lapaʻau.

No nā pakeke a me nā keiki he 12 a ʻoi aku o 12 makahiki, e noi ʻia nā palapala hoʻopiʻi e pili ana i ka hoʻokō intravenous:
Kuhi ʻia nā kiko o kahi 200 ml vial (100 mg o pentoxifylline) e hoʻolele ʻia me ka hoʻoneʻe loa ʻana i mau minuke no 90-180 mau minuke.
Me ka hoʻomanawanui maikaʻi, hiki ke hoʻonui i ka nui me ka hoʻonaninani uila intravenous i ka 200-300 mg (e like me ka 400-500 ml o ka hoʻonā).
ʻO ka lōʻihi maʻamau o ka papa o ka mālama ʻana, ma ke ʻano he lula, ʻo ka 5-7 mau lā a e hilinaʻi ʻia ana i ka dinamics o ka maʻi. I ka wā e hiki mai ana, hiki i ka mea maʻi ke neʻe i ka waha o ka pentoxifylline.
ʻO ka dosis kiʻekiʻe loa ʻo kēlā me kēia lā he 300 mg.

Hiki iā ia ke hoʻohana i ka lāʻau lapaʻau no ka mālama ʻana i nā keiki ma lalo o 12 mau makahiki a me nā keiki hou. I ia mau pilikia, e kāʻili ʻia ke ʻano ma ka paona o ke kino. No nā keiki ma lalo o 12 mau makahiki o ke ʻano he kānāwai, ua kau ʻia ʻo Latren ma kahi hoʻokahi no 5 mg (10 ml Latren solution) no 1 kg o ke kino o ke kino.

Nā hopena hopena

Ke hoʻohana nei ʻo Latren i nā maʻi maʻi, hiki i ka hoʻomohala ʻana o nā hopena maikaʻi ʻole ma muli o ka pentoxifylline.
Mai ka ʻōnaehana hoʻonāukiuki: nā pilikia hiamoe, hōʻeha, hōʻeha, mālama hopohopo, ʻili ʻole. I nā hihia kaawale, ua ʻike ʻia ka hoʻomohala ʻana o ka meningitis aseptic.
Ma ka ʻāpana o ka ʻōnaehana hematopoietic, nā naʻau a me nā kīʻaha koko: nā maʻi o ka ʻili o ka ʻili o ka maka a me ke kino o luna, edema, angina pectoris, arrhythmia, tachycardia, cardialgia, arterial hypotension, leukopenia, thrombocytopenia, pancytopenia.

Mai ka ʻōnaehana hepatobiliary a me ka hāhai ʻana o ka huina: atony ʻōpū, nausea, luaʻi, anorexia, cholestatic hepatitis, exacerbation of cholecystitis, hoʻonui i ka hana o nā enzyme ate.
ʻO kekahi: hematomas, koko koko i loko, hoʻohaʻahaʻa i ka acuity ʻike, hoʻonui i ka palupalu o nā kui.
Nā hui kūloko: hyperemia o ka ʻili, kaʻeha, ka urticaria, ka pīhoihoi anaphylactic, angioedema.

Nā Hoʻohui

ʻAʻole i hāʻawi ʻia ʻo Latren i ka poʻe maʻi me nā hypersensitivity i ʻike ʻia i kekahi o nā mea o ka lāʻau, a me nā derantava xanthine.
ʻAʻole pono e hoʻohana ʻia ka Latren no ka mālama ʻana i nā poʻe maʻi me ka maʻi myocardial acute infarction, porphyria, retinal hemorrhage, hemorrhagic stroke, mau ʻano koʻikoʻi o ka atherosclerosis cerebral a i ʻole coronary.
ʻAʻole i hoʻohana ʻia ʻo Latren e hana i nā mea maʻi e hōʻeha nei i ka arrhythmia, hypotension arterial control, renal a hepatic insufficiency, me nā mea maʻi me ka maʻi nui.

E nānā pono ka makaʻala ma ke kau ʻana iā Latren i nā mea maʻi me ka maʻi mellitus, ka uha ʻole ʻana, ulia peptic o ka ʻōpū a i ʻole duodenum, me nā mea maʻi maʻi maʻi.
E pono e makaʻala ka makaʻala i ke kau ʻana iā Latren i nā mea maʻi e holo ana (e mālama pono ana i ka hemoglobin a me ka hematocrit) pono.

Hoʻohui nūhou

ʻO ka hōʻemi e hōʻemi ana i ka hopena therapeutic o pentoxifylline.
Hiki i ka lāʻau Latren me ka hoʻohana pūʻana e hiki ke hoʻonui i ka hopena o nā anticoagulants pololei a kūlike a me nā mea he thrombolytic. Hoʻohui ʻia ka hoʻohana ʻia ʻana o kēia mau lāʻau me ka mālama mau ʻana i ka ʻōnaehana koko coagulation.
Hoʻohana ʻo Latren me ka hoʻohana pinepine i ka hana a nā pakano cephalosporin.
ʻO ka Pentoxifylline, i ka wā i hoʻohana pū ʻia, e hoʻolōʻihi i ka hopena o ka waikeka valproic, nā lāʻau antihypertensive, nā mea āpau a hypoglycemic waha a me ka insulin.

Hoʻonui ka ʻike o ka pentoxifylline i loko o ke koko me ka hoʻohana hoʻohui me ka cimetidine.
ʻO ka hoʻohana pū ʻana o ka lāʻau Latren a me nā lāʻau lapaʻau xanthine derivatives hiki ke alakaʻi i ka hoʻomohala ʻana o ka nū overexcitation.

Ke keu

Ke hoʻohana nei i nā nui o nā pentoxifylline i nā maʻi, nā maʻi, nā nāwaliwali, nāwaliwali, nā hypotension arterial, ke hiamoe nei, a i ʻole arousal e ulu. Eia kekahi, me ka hoʻonui hou aʻe o ka wai o Latren, ua ʻike nā mea maʻi i ka hoʻomohala ʻana o ka tachycardia, hyperthermia, ka nalowale o ka hoʻomaopopo, areflexia, ka maʻi gastrointestinal, a me ka hopu.

ʻAʻohe mea antidote kikoʻī. I kahi hihia o ka overdose, e kuhikuhi i ka lāʻau lapaʻau e kuhikuhi ana i ka hoʻopau ʻana i nā hōʻailona o ka hoʻomohala me ka pentoxifylline.
Pono e lawe ʻia ka lāʻau maʻi overdose ma loko o ka haukapila ma lalo o ka mālama mau o nā limahana lapaʻau.

Pākuʻi helu

Hoʻopili Infusion 0.5 mg / ml

1 ml o ka lāʻau pili

mea waiwai - pentoxifyll

kaʻiliwaiwai: sodium chloride, potassium chloride, calcium chloride, sodium lactate, wai no ka ʻomaʻomaʻo.

ʻAʻohe kala a melemele paha wai kahe.

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau

ʻO ka papa nui ʻo ka pharmacologically active metabolite 1- (5-hydroxyhexyl) -3,7-dimethylxanthine (metabolite I) i hoʻoholo ʻia i ka plasma i loko o kahi kukū ʻoi aku he 2 mau manawa o ka paʻa ʻana o ka waiwai i hoʻololi ʻole ʻia a aia i loko o kahi kūlana e hoʻohālikelike i ka kūlohelohe biochemical me ia. I kēia mea, pono ka pentoxifylline a me kāna metabolite i manaʻo ʻia he ʻano ikaika. ʻO ka hapalua hapalua o ka pentoxifylline he 1.6 mau hola.

ʻO ka pentoxifylline i hoʻohālikelike maoli ia; ʻoi aku ma mua o ka 90% ka hoʻopili ʻia e nā ʻōpū ma ka ʻano o ke ʻano o ka metabolites polū o ka walaʻau, wai-soluble. ʻOi aku ka liʻiliʻi ma 4% o ka loaʻa i ka waiʻai e hoʻopiʻi ʻia i loko o nā feces. I nā maʻi me nā maʻi hānai koʻikoʻi, hele lohi ka excretion o nā metabolites. I ka poʻe maʻi me ka pīhoihoi hana pōmaikaʻi, ua ʻike ʻia kahi hoʻonui o ka hapalua-ola o ka pentoxifylline.

Lapaʻau lāʻau

ʻO Pentoxifylline kahi kumu derivative methylxanthine. Hoʻopili ʻia ka hana o ka hana o ka pentoxifylline i ka pale ʻana o ka phosphodiesterase a me ka hōʻiliʻili o 3,5-AMP i nā kōneʻeneʻo ʻōiwi pololi, nā wahī a me ke ʻano o nā ʻili a me nā ʻili. Hoʻopili ka Pentoxifylline i ka hoʻohui ʻana o nā platelets a me nā sela koko māhuahua, hoʻonui i ko lākou ala, e hoʻoneʻeneʻe i ka nui o ka fibrinogen i loko o ke koko koko a hoʻonui i ka fibrinolysis, e hōʻemi ana i ka lapuwale o ke koko a hoʻomaikaʻi i kona waiwai rheological. Eia kekahi, ʻo ka pentoxifylline kahi nāwaliwali myotropic vasodilator hopena, e hoʻohaʻahaʻa iki i ka kūmole kūloko peripheral ma ke ʻano he hopena inotropic maikaʻi. Ma muli o ka hoʻohana ʻana o ka pentoxifylline, ka hoʻopaloli ʻana a me ka hāʻawi ʻana i ka oxygen i nā ʻili, hoʻomaikaʻi i ka nui o nā limu, ka pūnaehana kūloko, a me ka maʻalahi i ka ʻeha. Hoʻomale iki ka lāʻau i nā moku coronary.

E hoʻokuʻu i ke ʻano a me ka ʻano

Loaʻa ka lāʻau lapaʻau i loko o nā palapalaʻano hana:

• ʻO ka hopena no ka hoʻokele intravenous a intramuscular: kahi wai kūpaʻa, kokoke ʻae ʻole ka ʻoniʻoni ʻole a me ka poni (2 ml a 4 ml paha i loko o nā ampoules, i loko o kahi pālepau o PVC (polyvinyl chloride) kiʻiʻoniʻoni o 1, 2 a i ʻole 5 mau ampoules, 1 pākaha huina ma ka pahu pepa)
• Nā papa i uhi ʻia: ʻili melemele (10 mau ʻāpana i kēlā me kēia kīwaha blister, 1 pākaʻi i loko o kahi pahu pahu.

1 ml o ka hoʻonā i loaʻa:

• ʻO ka papa hana: luaansetron hydrochloride dihydrate (ma nā ʻōlelo o ka luaansetron) - 2 mg,
• ʻO nā mea kōkua: hydrochloric acid, sodium chloride, wai no ka injection.

1 papa pāhiʻi paʻa:

• ʻO ka papa hana: ondansetron hydrochloride dihydrate (ma nā ʻōlelo o ka luaansetron) - 4 mg,
• ʻO nā mea kōkua: Aerosil (colloidal silicon dioxide), microcrystalline cellulose, magnesium stearate, hua kākala,
• Shell: hydroxypropyl cellulose (hyprolose), tropeolin O, polysorbate (ʻumikūmāwalu-80), hinu koki.

Kahawai

ʻAʻole i lawa ka ʻike me ka hoʻohana ʻana i ka lāʻau lapaʻau i nā wahine hāpai.
No laila, koho Latren ʻaʻole i ʻōlelo ʻia ka wā hāpai.
ʻO ka Pentoxifylline i kahi liʻiliʻi liʻiliʻi e komo i loko o ka waiū umauma. Inā hoʻoholo ʻia ka mālama ʻana me Latren, pono e hoʻōki ka mālama umauma.

Hoʻopili pū me nā lāʻau ʻē aʻe

Latren hiki ke hoʻonui i ka hopena o nā lāʻau lapaʻau e pili ana i ka ʻōnaehana coagulation o ke koko (kūlike a me ka pololei anticoagulants, thrombolytics). Hoʻonui i ka hopena o nā antibiotics cephalosporins (cefamandol, cefoperazone, cefotetan) ma ka hoʻomaikaʻi ʻana i ka ke komo ʻana o ka antibiotics i loko o ka kiko me ka hoʻonui ʻana i ke kahe koko vascular. Hoʻonui i ka hana a ka valproic acid. Hoʻonui i ka pono o nā lāʻau antihypertensive, insulin a me ka lāʻau hypoglycemic waha. Hoʻonui ʻo Cimetidine i ka uluʻana o Latren i ka plasma koko, e hoʻopiʻi ana i ka nui o nā hopena o nā ʻaoʻao.
ʻO ka hoʻohana pū ʻana o ka lāʻau me nā derivatives xanthine hiki ke alakaʻi i ka overexcitation nē.

Hoʻopili i nā lāʻau lapaʻau

Hiki ke hoʻonui ʻia ka hopena o ka hoʻohaʻahaʻa i ke kōhi koko i loaʻa i ka insulin a i ʻole nā ​​ʻāpana antidiabetic waha. No laila, e nānā pono ʻia nā maʻi e loaʻa ana i ka lāʻau lapaʻau no ka maʻi diabetes.

Ma ka manawa o ke kūʻai aku, ua hōʻike ʻia nā hihia o ka hana anticoagulant i nā maʻi nā mea i mālama ʻia me ka pentoxifylline a me ka anti-vitamin K. Ke kuhikuhi ʻia a loli paha ka nui o ka pentoxifylline, ua ʻōlelo ʻia e nānā i ka hana anticoagulant i kēia hui o nā mea maʻi. Hiki i ka Pentoxifylline ke hoʻoikaika i ka hopena hypotensive o nā lāʻau antihypertensive a me nā lāʻau lapaʻau ʻē aʻe e hiki ai ke hoʻopau i ke kahe o ke koko. ʻO ka hoʻohana like ʻana o ka pentoxifylline a me theophylline i kekahi mau mea maʻi hiki ke alakaʻi i ka hoʻonui i nā pae o theophylline i loko o ke koko. No laila, hiki iā ia ke hoʻonui i ke alapine a hoʻonui i nā hōʻike o nā hopena ʻino o ka theophylline.

Lauluu.ʻAʻole hoʻohui ʻia ka lāʻau lapaʻau me nā lāʻau ʻē aʻe i ka pahu like.

Nā ʻōlelo kikoʻī

I nā hōʻailona mua o ka hopena anaphylactic / anaphylactoid, pono e hoʻokaʻawale i ka lāʻau lapaʻau a nīnau aku i kekahi kauka. I ka hihia o ka hoʻohana pono ʻana i ka lāʻau lapaʻau, nā mea maʻi me ka maʻi puʻuwai kūpilikiʻi e pono mua i ka pae ʻana o ka uku koko.

I ka poʻe maʻi me ka maʻi mellitus a me ka loaʻa i ka mālama ʻana me ka insulin a me nā lā lāʻau antidiabetic waha, i ka wā e hoʻohana ai i nā lāʻau kiʻekiʻe o ka lāʻau, hiki ke hoʻonui i ka hopena o kēia mau lāʻau i ke kō koko koko (e ʻike i ka ʻāpana "Nā Pāʻina Kūleʻa"). I kēia mau pilikia, pono e hōʻemi ʻia ka nui o ka insulin a i ʻole nā ​​lāʻau antidiabetic waha, a pono e nānā pono ka mea maʻi. ʻO nā mea maʻi me ka systemus lupus erythematosus (SLE) a me nā maʻi ʻē aʻe o ka hoʻopili hoʻohui hiki ke kuhikuhi i ka pentoxifylline ma hope wale nō o ka nānā ʻana i nā hōʻeha kūpono a me nā pono. Ma muli o ka mea e pili ana i ka hoʻomohala ʻana i ka anemia aplastic i ka wā e mālama ai me ka pentoxifylline, pono e nānā pono ʻia ka helu ʻana o ka nui o ke koko.

I nā mea maʻi me ka renal maikaʻi ʻole (ʻo ka hana ʻana ma lalo iho o 30 ml / min) a i ʻole nā ​​mea hōʻeha kino, pentoxifylline e hoʻopoki. E koi ʻia ka nānā ʻana.

Pono e nānā pono ai.

- nā mea maʻi me nā arrhythmias cardiac koʻikoʻi,

- nā mea maʻi me ka myocardial infarction,

- nā mea maʻi me ka hypotension arterial,

- nā mea maʻi me ka atherosclerosis koʻikoʻi o ka lolo a me nā moku coronary, keu me ka concomitant arterial hypertension a cardiac arrhythmias. I kēia mau maʻi maʻi, i ka wā e lawe ai i ka lāʻau, hiki i ka hōʻeha ʻana o ka angina pectoris, nā arrhythmias a me ka hypertension arterial.

- nā mea maʻi me ka hikiʻole o ka renal (hoʻopili i ka hana ma lalo o 30 ml / min),

- nā mea maʻi me ka hōʻaʻe o ka puʻuwai hōʻeha,

- nā mea maʻi me ka makemake nui o ke kahe, nāu, no ka laʻana, e ka mālama ʻana me anticoagulants a i ʻole nā ​​maʻi koko. E pili ana i ke kahe - ʻike i ka ʻāpana "Contraindications".

- nā mea maʻi nona ka hōʻemi i ke koko i pilikia nui (no ka laʻana, nā mea maʻi me ka maʻi ʻeha coronary hōʻeha a i ʻole ka ven stenosis e hoʻolako i ke koko i ka lolo),

- nā mea maʻi e loaʻa pū ana i ka mālama ʻana me ka pentoxifylline a me antivitamins K (e ʻike i ka ʻāpana "Nā Pānaʻi Kūloko"),

- nā poʻe maʻi e loaʻa pū ana i ka mālama ʻana me nā pentoxifylline a me nā mea hoʻomehana antidiabetic (e nānā i ka ʻāpana "Nā Pāʻina Kūleʻa").

Hoʻohana i ka wā hāpai a lactation. I ka wā hāpai a me ka lactation, ua hoʻohana like ka hoʻohana ʻana i ka lāʻau.

E na keiki. ʻAʻoheʻike me ka hoʻohana o ka lāʻau lapaʻau i nā keiki.

Nā hiʻohiʻona o ka hopena o ka lāʻau lapaʻau ma ka hiki ke lawe i kahi kaʻa a i ʻole nā ​​hana ʻē aʻe e weliweli

ʻO ka mea i hoʻohana ʻia i ka lāʻau lapaʻau, ʻaʻohe ʻikepili e pili ana i kēlā mau hopena.