Atomax (Atomax) - nā ʻōlelo hoʻohana no ka hoʻohana ʻana

Inoa inoa honua - atomax

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

Nā papa hana ʻulaʻī aneane keʻokeʻo, puni, biconvex, me kahi ʻokiʻahi ma kahi ʻaoʻao, ʻae ʻia ka paʻakikī. Aia ka papa 1 i ka atorvastatin (ma ke ʻano o ka calcium trihydrate atorvastatin) 10 mg.

Nā mea kūʻai: ka carbonate carbonate - 6 mg, lactose - 52.5 mg, kaʻai palaoa - 25,66 mg, sodium croscarmellose - 5.21 mg, povidone (K-30) - 3,5 mg, kaomi stānate magnesium - 2 mg, anhiddrous colloidal silicon dioxide - 1.5 mg, crospovidone - 4 mg

Hoʻolālā: primellose 15 CPS - 2.05 mg, talc maʻemaʻe - 0.22 mg, titanium dioxide - 0.36 mg, triacetin - 0.16 mg.

10 kamepiula - blisters (3) - nā ʻeke pepa.
10 kamepiula - nā kāmele (4) - nā ʻeke pepa.
10 kamepiula - nā kāmele (5) - nā kāʻei o ke kāleka.

Nā mea kūʻai: ka calcium carbonate - 10 mg, lactose - 78.34 mg, starch corn - 40 mg, sodium croscarmellose - 10,47 mg, povidone (K-30) - 5 mg, magnesium stearate - 4 mg, anhydrous colloidal silicon dioxide - 3 mg, crospovidone - 7 mg

Hoʻolālā: primellose 15 CPS - 3.3 mg, purc talc - 0.36 mg, titanium dioxide - 0.58 mg, triacetin - 0.26 mg.

10 kamepiula - blisters (3) - nā ʻeke pepa.
10 kamepiula - nā kāmele (4) - nā ʻeke pepa.
10 kamepiula - nā kāmele (5) - nā kāʻei o ke kāleka.

Nā ʻoihana ʻoihana ʻo ka ʻoihana kāohi me ka lāʻau lapaʻau

ʻĀpana Pharmacotherapeutic

ʻO ka mea molum-e hoʻohaʻahaʻa i ka HMG-CoA reductase inhibitor.

ʻO ka hana lāʻau lapaʻau ma Atomax

ʻO ka maʻi Hypolipidemic mai ka pūʻulu o nā statins. ʻO ka mea hoʻokūkū koho koho HMG-CoA reductase, he enzyme e hoʻololi i ka 3-hydroxy-3-methylglutaryl coenzyme A i ka mevalonic acid, kahi mea mua o ka sterols, me ka kolamu. Hoʻokomo ʻia ka TG a me ka cholesterol i loko o ka ate ma VLDL, e komo i ka plasma a e lawe ʻia i nā kino peripheral.

Hoʻokumu ʻia ka LDL mai VLDL i ka wā o ke kikowaena me nā mea hopu LDL. He hōʻemi ia i ka kukuna o ka kolamu a me nā lipoproteins i ka plasma ma muli o ka pale ʻana o ka HMG-CoA reductase, ka synthesis o ka kolamu ma ka ate a me ka hoʻonui ʻana o ka nui o nā "recepty" LDL ma ka ʻaoʻao o ka cell, e alakaʻi ai i ka hoʻonui nui a me ka catabolism o LDL.

Hoʻemi i ka hoʻokumu ʻana o LDL, e hoʻoiho i ka hoʻonui nui ʻana a me ka hoʻomau i ka hana o nā ʻāpono LDL. Hoʻolaha i ka hoʻololi LDL i nā mea maʻi me ka hypercholesterolemia homozygous, kahi maʻamau ʻaʻole e pane aku i ka maʻi maʻi me nā lipid-hoʻemi haʻahaʻa.

Hoʻemi ia i ka kukuna o ka kolamu nui o ka 30-46%, LDL - e ka 41-61%, ka apolipoprotein B - e 34-50% a ʻo TG - e ka 14-33%, kumu i ka hoʻonui ʻana o ka holomua o ka HDL kolamu a me ka apolipoprotein A. ʻO ka d-paʻa i ka hoʻoneʻe ʻana o ka LDL ma nā mea maʻi me ka maʻi homozygous hypercholesterolemia pale i ka lāʻau me nā lāʻau lapaʻau hypolipidemic.

Hoʻonui koʻikoʻi i ka hiki ke hoʻomohala ʻana i nā hoʻopiʻi ischemic (me ka hoʻomohala ʻana o ka make mai ka myocardial infarction) ma ke 16%, ka loaʻa ʻana o ka hoʻoliʻi hou ʻana no ka angina pectoris, i hui pū ʻia e nā hōʻailona o ka ischemia myocardial, ma ka 26%. ʻAʻohe o carcinogen a me nā hopena mutagenic. Loaʻa ka hopena therapeutic i 2 mau pule ma hope o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa, hiki i ka nui ma hope o 4 mau pule a kū i ka wā mālama.

Lapaʻau lāʻau

He kiʻekiʻe nā Absorption. He manawa e hiki ai i C_max - 1-2 hola, C_max ke kumu ikaika i ka plasma koko i nā wahine he 20% kiʻekiʻe, ʻo AUC ma lalo o 10%, Cmax i nā mea maʻi me ka cirrhosis alikaole he 16 mau manawa, ʻo AUC he 11 mau manawa ma mua o ka maʻamau. Hōʻemi ka meaʻai i ka wikiwiki a me ka lōʻihi o ka lawe ʻana mai i ka lāʻau (e 25% a me 9%, pākahi), akā me ka hoʻēmi ʻana o ka kolamu LDL e like like me ka hoʻohana ʻana o ka atorvastatin me ka ʻole o ka meaʻai.

ʻO ka ʻike o ka atorvastatin i ka wā i ke ahiahi ma lalo iho o ke kakahiaka (ma kahi o 30%). Ua hōʻike ʻia kahi pilina palena ma waena o ke kūkaʻi o ka huina a me ka loaʻa ʻana o ka lāʻau lapaʻau. Bioavailability - 14%, bioavailability o ka ʻōnaehana o ka hana pale i kūʻē i ka HMG-CoA reductase - 30%.

ʻO ka bioavailability systemic haʻahaʻa ma muli o ka metabolism presystemic i ka membous mucous o ka gastrointestinal tract (GIT) a i ka wā o ka "hopena mua" ma o ka ʻōpala. ʻO ka nui o Vd he 381 L, ka pilina me nā protein plasma eʻoi aku ma mua o 98%. Ka hana i ka nui ma ka ate ma lalo o ka hana a isoenzymes CYP3A4, CYP3A5 a me CYP3A7 me ka hoʻokumu ʻana o nā metabolites hoʻolaʻa aikela (ortho and parahydroxylated derivatives, nā huahana o beta oxidation).

In vitro, ortho- a me para-hydroxylated metabolites he hopena pale i ka GMK-CoA reductase, i hoʻohālikelike ʻia i ka atorvastatin. ʻO ka hopena o ka hopena o ka lāʻau e kūʻē i ka HMG-CoA reductase ma kahi o 70% i hoʻoholo ʻia e ka hana o nā kaila e hoʻoponopono i ka metabolites a hoʻomau i ka nui o nā hola 20-30 ma muli o ko lākou heleʻana. T_1/2 - Nā hola 14. Ua kāpili ʻia me ka bile ma hope o ka hepatic a / a i ʻole ka hoʻokūkū extrahepatic (ʻaʻole i komo i ka haʻi ʻana o ka enterohepatic). ʻOi ka liʻiliʻi o 2% o kahi kūpono i loko o ka waiʻai.

ʻAʻole ia i hoʻōla ʻia i ka wā o hemodialysis ma muli o ka hoʻopili koʻikoʻi i nā protein plasma.

Me ka hikiʻole o ka puʻuwai ma nā maʻi me ka cirrhosis alikaole (Child-Pyug B), Cmax a me AUC nui e hoʻonui (16 a 11 mau manawa, kēlā).

C_max a me AUC o ka lāʻau i ka poʻeʻelemakule (65 mau makahiki he 40) a 30% ka mea, ʻoi aku ka nui o ke kiʻekiʻe o nā mea maʻi o nā makahiki ʻōpio (ʻaʻohe kumu lāʻau lapaʻau). ʻO Cmax ma nā wahine he 20% kiʻekiʻe, a ʻo AUC he 10% haʻahaʻa ma mua o nā kāne (ʻaʻohe kumu koʻikoʻi lāʻau).

ʻAʻole hoʻopiʻi ka hōʻino Renal i ka plasma o ka lāʻau.

- e hui pū me kahi papa meaʻai no ka mālama ʻana i nā maʻi me ka serum TG kiʻekiʻe (ʻano IV ma muli o Fredrickson) a me nā mea maʻi me dysbetalipoproteinemia (type III e like me Fredrickson), ka mea e hāʻawi ʻole ai i ka mea mālama ʻaʻai kūpono i ka hopena kūpono.

- i hui pū me ka papaʻaina e hōʻemi i nā kiʻekiʻe kiʻekiʻe o ka kolamu, LDL-C, apolipoprotein B a me TG a hoʻonui i ka HDL-C i nā mea maʻi me ka hypercholesterolemia primera, ka heterozygous familial a non-familial hypercholesterolemia a hui pū (a hui pū ʻia) hyperlipidemia (nā ʻano IIa a me IIb IIb )

- e hōʻemi i nā kiʻekiʻe o ka kolamu a me LDL-C i nā mea maʻi me ka hypercholesterolemia homozygous a i ka wā i mālama ʻia ai ka mālama ʻana i nā meaʻai a me nā lāʻau lapaʻau ʻole non-pharmacological maikaʻi ʻole.

Ka hoʻoponopono ʻia ʻana

Ma mua o ka manawa i koho ʻia ai ka Atomax, pono e hoʻomaʻamaʻi ka mea maʻi i kahi meaʻai lipid-hoʻemi haʻahaʻa, pono e hoʻomau ʻo ia e nānā i nā manawa holoʻokoʻa o ka hopena.

ʻO ka ma mua mau ka awelika o 10 mg 1 mau lā / lā. Hoʻololi nā ʻōhua mai 10 a 80 mg 1 mau lā / lā. Hiki ke kiʻi ʻia ka lāʻau i kēlā me kēia manawa o ka lā me ka meaʻai a me ka ʻole o ka manawa ʻai. Koho ʻia ka ʻōkole me ka lawe ʻana i nā pae mua o LDL-C, ke kumu o ka lāʻau a me ka hopena pilikino. I ka hoʻomaka ʻana o ka hoʻōla a me / a i ka manawa o ka hoʻonui ʻana i ka mahele o ka Atomax, pono ia e nānā i nā pae lipid plasma a i nā wiki he 2 mau minamina a hoʻoponopono i kēia mau ʻōlelo ma muli.

I hypercholesterolemia mua a me ka hyperlipidemia hoʻopili i ka manawa pinepine, ua lawa ke koho o Atomax ma kahi lāʻau o 10 mg 1 manawa / lā ua lawa. Hoʻomaopopo ka hopena therapeutic koʻikoʻi ma hope o 2 mau pule, ma ke ʻano he kānāwai, a me ka hopena therapeutic ākea e nānā pinepine ʻia ma hope o 4 wiki. Me ka lōʻihi o ka mālama ʻana, hoʻomau kēia hopena.

Ka hoʻohana o ka lāʻau lapaʻau i nā mea maʻi me ka maikaʻi ʻole a me nā maʻi ʻeha ʻaʻole e pili i ka pae o ka atorvastatin i loko o ke kaila koko a i ʻole ka pae o ka hōʻemi i nā mea i loko o LDL-C i ka wā e hoʻohana ʻia ai, no laila, ʻaʻole pono ka loli o ka nui o ka lāʻau.

Ke hoʻohana ʻia i ka lāʻau lapaʻau i loko nā maʻi maʻi maʻi ʻaʻohe ʻokoʻa i ka palekana, ka hopena, a me ka hoʻokō ʻana o nā pahuhō i ka maʻi lipid-hoʻohālikelike ʻia i ka poʻe nui.

Loaʻa ka hopena Atomax

Mai nā ʻike: amblyopia, ke kani ana i ka pepeiao, ka maloo o ka conjunctiva, kahi haunaele o ka noho ʻana, hemorrhage ma ka maka, kamaʻū ʻana, hoʻonui i ka paila intraocular, parosmia, hoʻowahāwahā i ka ʻono, nā ʻōpū o ka hoʻāʻo ʻana.

Mai ka ʻaoʻao o ka ʻōnaehana hoʻonāukiuki a me ka ʻōnaehana hoʻāʻo o peripheral: hōʻeha, hōʻeha, asekoic syndrome, ʻehaʻeha aiʻole hiamoe, nightmares, amnesia, paresthesias, peripheral neuropathy, ka hana naʻau, ataxia, hyperkinesis, ʻehaʻeha, hypesthesia.

Mai ka pūnaehana hana ʻana: nausea, heartburn, constipation or diarrhea, flatulence, gastralgia, abdominal pain, anorexia a hoʻonui ʻia momona, waha maloʻo, belching, dysphagia, luaʻi, stomatitis, esophagitis, glossitis, gastroenteritis, hepatitis, colic hepatic, cheilitis, duodenal ulcer pancreatitis, jaundice cholestatic, hoʻonui i ka hana o nā enzymes ati (AST, ALT), pehu kūloko, melena, kahe koko, tenesmus.

Mai ka ʻōnaehana musculoskeletal: ʻōpū, nā hīnaʻi wāwae wāwae, bursitis, myositis, myopathy, arthralgia, myalgia, rhabdomyolysis, hui pū kekahi, ʻeha hope, hoʻonui i ka serum CPK.

Mai ka papa hana hanu: ʻO bronchitis, rhinitis, dyspnea, bronchial asthma, nosebleeds.

Mai ka pūnaehana urinary: urogenital impiry, peripheral edema, dysuria (me ka pollakiuria, nocturia, urinary incontinence or urinary retence, imperial urination), nephritis, cystitis, hematuria, urolithiasis, albuminuria.

Mai ka ʻōpiopio: puki ka ʻōpū, ʻōpū o ka ʻōpū, metrorrhagia, epididymitis, hoʻemi i ka libido, ka impotence, ʻike ʻia ejaculation, gynecomastia.

Nā hopena dermatological: alopecia, liki, eczema, seborrhea, ecchymosis.

Mai ka pūnaehana cardiovascular: ʻehaʻeha umauma, palpitations, vasodilation, orthostatic hypotension, phlebitis, arrhythmia.

Mai ka ʻōnaehana hemopoietic: anemia, lymphadenopathy, thrombocytopenia.

Mai ka ʻaoʻao o ka metabolism: hyperglycemia, hypoglycemia, kaupaona momona, hoʻōla o ka papa o ke gout, fever.

Nā maʻi kūwaha: pruritus, pili kino, ʻiliʻili dermatitis, līpiki urticaria, angioedema, facema edema, photosensitivity, anaphylaxis, erythema multiforme exudative (pū me ke ʻano o Stevens-Johnson syndrome), nā mea hou aku i ka ʻōpū epidermal epidermal (ʻelllelo Lyell).

Nā Hoʻohui Atomax

- makahiki a hiki i ka 18 makahiki (ʻaʻole i hoʻokū ʻia ka maikaʻi a me ka palekana)

- maʻi maʻi patia a i ʻole ka hoʻonui ʻana i ka hana o nā transaminases serum (ʻoi aku ma mua o 3 mau manawa i hoʻohālikelike ʻia me VGN) o kahi kumu ʻike ʻole,

- Kūpono o nā maʻi o ka lāʻau.

Me ka akahele lilo i ka palaka maʻi kūloko, me ka mōʻaukala o ka maʻi o ka puʻuwai, hōʻemi ʻana i ka electrolyte koʻikoʻi, endocrine a me ka metabolic disorders, ʻimi arterial, maʻiʻeha koʻikoʻi (sepsis), epilepsy kūleʻa ʻole, ka nui o ka hōʻeha, nā hōʻeha, nā maʻi ʻeha o ke kākala.

ʻŌpū a me ka lactation

Contosicated ʻo Atomax i ka wā hāpai a me ka lactation (umauma maʻi).

ʻAʻole i ʻike ʻia inā excreted i ka atorvastatin i loko o ka waiū umauma. Hāʻawi i ka hiki ke hanana ʻino loa i nā pēpē, inā pono, hoʻohana i ka lāʻau lapaʻau i ka wā lactation e hoʻoholo i ka hoʻopau ʻana o ka ʻōpū.

ʻO nā wahine o nā makahiki hānau i ka wā e pono ai ka hoʻohana ʻana i nā ala kūpono o ka ʻohu. Hiki ke kuhikuhi ʻia ʻo Atorvastatin i nā wahine o ka hānau ʻana inā he haʻahaʻa loa paha ka hiki ʻana o ka hapai, a haʻi ʻia ka mea maʻi e pili ana i ka hiki ke kūpono no ka mālama ʻana i ka pūpū.

Hoʻohana no ka hana lawelawe lēwa

Ua hoʻohaumia ʻia ʻo ia i nā maʻi ʻoi aku ka maʻi a me ka hoʻonui ʻana ma ka hana o nā seramin transaminases (ʻoi aku ʻoi aku ka 3 manawa i hoʻohālikelike ʻia me VGN) o ka kumu ʻike ʻole. Ua hoʻohana ʻia me ka mālama aka i ka waiʻona maʻi maʻamau, me ka mōʻaukala o ka maʻi pūpū.

Hoʻohana no ka hana renal impaired

ʻAʻole pili ka maʻi o ka pūpū i ka hoʻomohala ʻana i ka atorvastatin i loko o ke kaila koko a i kona hopena paha i ka moliki lipid. Ma kēia noʻonoʻo, ʻaʻole pono ka hoʻololi ʻia ʻana o ka hopena i nā mea maʻi me nā hana renal impaired. ʻOiai, ʻaʻole i mālama ʻia nā haʻawina i nā maʻi me nā ʻāpana o nā maʻi o ka pēpē, ʻaʻole hiki ke hoʻonui ʻia ka hemodialysis e hoʻonui i ka hoʻomaʻemaʻe o ka atorvastatin, no ka mea i hoʻopaʻa mau ʻia i nā protein plasma.

ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau i nā keiki

Contraindicated: makahiki a hiki i ka 18 makahiki (ʻaʻole i hoʻokū ʻia ka palekana a me ka palekana).

Hoʻohana i nā mea maʻi maʻi

Nā ʻōlelo kikoʻī kūikawā no ke komo ʻana

Ma mua o ka hoʻomaka ʻana i ka maʻi Atomax, pono e hoʻokaʻawale ʻia ka mea maʻi i kaʻai hypocholesterol maʻamau, e pono ai ʻo ia e hahai ai i ka manawa holoʻokoʻa.

ʻO ka hoʻohana ʻana o HMG-CoA reductase inhibitors e hoʻohaʻahaʻa i nā lipids koko e hiki ke alakaʻi i kahi hoʻololi i nā ʻōhua biochemical e hōʻike ana i ka hana ate.

Pono ka nānā ʻana o ka naʻau ma mua o ka hoʻomaka ʻana i ka hoʻolaʻa, 6 a me 12 mau pule ma hope o ka hoʻomaka ʻana o ka hoʻokele ʻana o Atomax a ma hope o ka hoʻonui ʻana o kēlā me kēia pākaukau, a ʻoi hoʻi kēlā me kēia manawa, no kēlā me kēia 6 mau mahina. I ka hoʻonui ʻia o ka hana o nā enzyme hepatic i loko o ka serum koko e hiki ke ʻike ʻia i ka wā o ka maʻi me ka Atomax. ʻO nā maʻi me ka hoʻonui ʻana o ka hana transaminase pono e nānā pono a hiki i ka pae o ka hāmeʻa e hoʻi i ka maʻamau. Ma nā hanana i loaʻa nā waiwai o ALT a me AST paha iʻoi aku ma mua o 3 mau manawa i ʻoi aku i ka VGN, ʻoi ʻia ka hoʻēmi ʻana ma ka hopena o Atomax a i ʻole ka hana ʻana i ka mālama ʻana.

Pono e hoʻohana ʻia ʻo Atomax me ka akahele i nā poʻe maʻi e hōʻino maikaʻi aku i ka waiʻona a / a i loaʻa iā ia kahi maʻi pehu, ka maʻi lūlū ikaika a i ʻole ka hoʻonui mau ʻana i ka hana transaminase o ka kumu ʻike ʻole ʻia he contraindication i ka lāʻau.

Hiki i ke mālama Atorvastatin ka mea i hiki i ka myopathy. ʻO ka maʻi o ka maʻi myopathy (ʻoi aku ka hōʻeha a me ka nāwaliwali i hui pū ʻia me ka hoʻonui ʻana i ka hana CPK ma o ka 10 mau manawa e hoʻohālikelike ʻia me VGN) e noʻonoʻo ʻia i loko o ka poʻe maʻi me ka myalgia maʻamau, ʻehaʻeha a nāwaliwali a / a i ʻole he mākaukau e hoʻonui i ka hana CPK. Hoʻomaʻamaʻa ʻia nā mea maʻi e hoʻomaopopo koke lākou i ke kauka e pili ana i nā hiʻohiʻona ʻole o nā hōʻeha a me ka nāwaliwali o nā uaua, inā e hele pū lākou me ka malaise a me ka maʻi maʻi. Pono e hoʻoneʻe ʻia ka lāʻauomaomaomaomaoma inā i ʻike ʻia ka hoʻonui ʻia o ka hana CPK a i ʻole i ke alo ʻia i hoʻopaʻa ʻia ʻole a i manaʻo ʻia myopathy. ʻO ka loaʻa ʻana o ka myopathy i ka mālamaʻana i nā lāʻau lapaʻau ʻē aʻe o kēia papa me ka hoʻohana pinepine ʻana o ka cyclosporine, fibrates, erythromycin, niacin a i nā mea āpau azif antolungal azole. He nui kēia mau lāʻau i ke hōʻemi ʻia e ka metabolism CYP3A4-mediated a me / a i ʻole ka lawe ʻana i ka lāʻau. Atorvastatin i biotransformed e CYP3A4.Ke koho ʻana i ka atorvastatin i hui pū me nā fibrates, erythromycin, immunosuppressive drug, azole antifungal drug or niacin in hypolipidemic doses, the benefit of benefit and risk of treatment to be weight careed and the patients should be obserent rutin to det pain pain or weakness, especially in the first months of treatment and in nā manawa o ka hoʻonui ʻana i nā papa o kekahi lāʻau lapaʻau. I kēlā mau kūlana, hiki ke ʻōlelo ʻia ke kau manawa holoʻokoʻa o ka hana KFK, ʻoiai ke pale ʻole ʻia ia i ka hoʻomohala ʻana i ka myopathy koʻikoʻi.

Ke hoʻohana ʻia i ka atorvastatin, a me nā lāʻau ʻai o kēia papa, ua hōʻike ʻia nā hihia o ka rhabdomyolysis me ka hana ʻole o ka papaleka ma muli o ka myoglobinuria. ʻO ka hoʻōla ʻana o ka atomax e hoʻopau iki a hoʻomaha ʻole inā loaʻa he mau hōʻailona o ka hiki ʻana i ka myopathy a i ʻole he hopena pilikia no ka hoʻoulu ʻana o ka renal hoʻoluhi ma muli o ka rhabdomyolysis (no ka laʻana, ʻoi aku ka maʻi uʻi nui, hypotension arterial, hoʻokō koʻikoʻi, trauma, hōʻeha metabola, endocrine a me nā hōʻaia electrolyte a me nā hana hoʻomāino ʻole ʻole).

Ma mua o ka hoʻomaka ʻana i ka maʻi Atomax, pono ia e hoʻāʻo e hoʻokō i ka hoʻopulapula o ka hypercholesterolemia ma ke ʻano kūpono o kaʻai ʻana, hoʻonui i ke kino kino, ke kaumaha ʻana i ka mea maʻi me ka momona a me ka mālama ʻana i nā kūlana ʻē aʻe.

Hoʻomaʻamaʻa ʻia nā mea maʻi e pono koke lākou e kūkā i ke kauka inā ʻaʻole i loaʻa ka ʻeha a i ʻole nā nāwaliwali o ka naʻau, inā ua hele pū lākou me ka malaise a me ka maʻi maʻi.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a kāohi i nā mīkini

ʻAʻole i hōʻike ʻia ka hopena maikaʻi o Atomax i ka hiki ke lawe i nā kaʻa a hana a me nā hana me nā mīkini.

Ke keu

Lāʻau: ʻaʻohe ʻano antidote kikoʻī, lawe ʻia ka lāʻau lapaʻau maʻi. ʻAʻohe huakino ka Hemodialysis.

Nā pilina pili me nā lāʻau lapaʻau ʻē aʻe

ʻO ka loaʻa ʻana o ka myopathy i ka wā o ka mālama ʻana me nā lāʻau ʻē aʻe o kēia papa e hoʻonui me ka hoʻohana pū ʻana i ka cyclosporine, fibrates, erythromycin, antifungal nā mea e pili ana i ka azoles, a me ka niacin.

Me ka manawa like o ka atorvastatin a me kahi kōnao i loaʻa i ka magnesium a me nā konohiko alumina, ua emi iho ka ʻike o ka atorvastatin i ka plasma e pili ana i ka 35%, akā naʻe, ʻaʻole i loli ka nui o ke kaohi o ka pae o LDL-C.

Me ka hoʻohana like ʻana o ka atorvastatin, ʻaʻole i hoʻopilikia i ka pharmacokinetics o antipyrine, no laila, ʻaʻole ka manaʻo ka launa pū me nā lāʻau ʻē aʻe e like me ka cytochrome isoenzymes.

Me ka hana like o colestipol, hoʻemi ʻia nā mea hoʻoliʻi i ka atorvastatin e like me 25%. Eia nō naʻe, ʻoi aku ka hopena o ka lipid-hoʻemi ʻana i ka hui o ka atorvastatin a me colestipol i kēlā me kēia pālolo.

Me ka hoʻokele mau ʻana o ka digoxin a me atorvastatin ma kahi maʻa o 10 mg, ʻaʻole i loli ka nui o nā kūhelu waiwai o ka digoxin i loko o ke koko koko. Eia naʻe, i ka manawa i hoʻohana ʻia ka digoxin i hui pū me ka atorvastatin ma kahi maʻa o 80 mg / lā, hoʻonui ʻia ka ʻike o ka digoxin ma kahi o 20%. ʻO nā maʻi e loaʻa ana i ka digoxin i hui pū me ka atorvastatin e pono e nānā.

Me ka hana like o ka atorvastatin a me ka erythromycin (500 mg 4 mau manawa / lā) a i ʻole clarithromycin (500 mg 2 mau manawa / lā), ka mea e kāohi ana i ka CYP3A4, he piʻi nui ka piʻi ʻana o ka plasma o ka atorvastatin i nānā.

Me ka hana like o ka atorvastatin (10 mg 1 manawa / lā) a me azithromycin (500 mg 1 manawa / lā), ʻaʻole i loli ka ulu ʻana o ka atorvastatin i loko o ke koko koko.

ʻAʻohe hopena koʻikoʻi ʻo Atorvastatin i ka paʻa ʻana o ka terfenadine i loko o ke kaila koko, aia ka mea nui i ka metabolly e CYP3A4; i kēia hana, ʻaʻole hiki i ka atorvastatin ke hana koʻikoʻi i ka pākuʻi pharmacokinetic o nā substrat CYP3A4 ʻē aʻe.

Me ka hana like o ka atorvastatin a me ka ulu o ka waha e loaʻa ana i ka norethindrone a me ka ethinyl estradiol, he ulu nui loa i ka AUC o norethindrone a me ka ethinyl estradiol i nānā ma kahi o 30% a 20%, ma kēlā. Pono e noʻonoʻo ʻia kēia hopena ke koho ʻana i kahi contraceptive ā waha no ka wahine e loaʻa ana i ka atorvastatin.

ʻAʻole i ʻike maka ʻia nā pili pōʻino koʻikoʻi o ka atorvastatin me nā estrogens.

Ke aʻo nei i ka hoʻopili ʻana o ka atorvastatin me warfarin a me cimetidine, ʻaʻohe i ʻike nui ʻia o nā maʻi lapaʻau.

Me ka hana like o ka atorvastatin ma kahi maʻa o 80 mg a me amlodipine ma kahi pākahi o 10 mg, ʻaʻole i loli ka hopena pharmacokinetics o atorvastatin i ke kīʻaha kūʻai.

ʻO ka hoʻohana kūpono ʻana o ka atorvastatin me nā inhibitor protease i kapa ʻia ʻo CYP3A4 inhibitors ua hele pū ʻia me ka hoʻonui o ka hiki ʻana o ka plasma o atorvastatin.

ʻAʻole i ʻike ʻia i nā hopena pōʻino koʻikoʻi o ka atorvastatin a me nā mea antihypertensive.

ʻAʻole ʻike ʻia ka hoʻohui lāʻau lapaʻau.

Hoʻohui Kūʻai Kūʻai

Ke kūleʻa aku nei ka lāʻau lapaʻau.

Nā kuleana a me nā kūlana e waiho ai

Papa inoa B. Pono e mālama ʻia ka lāʻau lapaʻau mai ka hiki ʻole o nā keiki, i kahi maloʻo a malū i kahi pālahalaha ʻaʻole i kiʻekiʻe ma mua o 25 ° C. ʻO 2 mau makahiki kahi ola.

ʻO ka hoʻohana ʻana i ka lāʻau atomax lapaʻau wale nō e like me ka mea i kuhikuhi ʻia e ke kauka, hāʻawi ʻia ka wehewehe no ke kuhikuhi!

He aha nā hōʻailona e hoʻomaopopo ai e hoʻomohala kahi kanaka i ka maʻi noʻonoʻo?

Noho ma ka hana a ao? Hoʻokahi wale nō hola o ka hoʻōho ʻana iā ʻoe e make i mua o ka manawa

He aha nā huahana lapaʻau e pilikia ai no nā kānaka?

No ke aha e puhi ai i kahi anuanu ke kumu o ke olakino olakino?

ʻO wai ke aniani ke ala a mākou e noʻonoʻo ai i ia?

ʻAʻole hiki ke hana ma hope o ka ʻai ʻana, i ʻole e hōʻino i ka olakino

Pehea e mālama ʻia ai i ka ʻeha ʻeha: nā lāʻau lapaʻau a i ʻole nā ʻano kumu ʻē aʻe?

Ma ka pae o menopause: aia paha kahi manawa e olakino ai a ololi ma hope o 45 mau makahiki?

ʻO Laserhouse Center - ʻO Laser Hair Removal a me ka Kosmetology ma Ukraine

E ʻike i ke keiki ʻole (keiki ʻole) - he whim a pono paha?

Nā hōʻailona no ka hoʻohana ʻana

Ka lāʻau Atomax hoʻohana ia i ka hui me ka papaʻaina e hōʻemi i nā kiʻekiʻe kiʻekiʻe o ka kolamu, LDL-C, apolipoprotein B a me TG a hoʻonui i ka HDL-C i nā mea maʻi me ka hypercholesterolemia primera, ka heterozygous ʻohana a me ka non-familial hypercholesterolemia a hui pū (hui pū ʻia) hyperlipidemia (nā ʻano IIa a me IIb IIb ), ke hui pū me ka mea ʻai no ka mālama ʻana i nā maʻi i ka kiʻekiʻe serum kiʻekiʻe o TG (type IV ma muli o Fredrickson) a me nā mea maʻi me dysbetalipoproteinemia (ʻano III e like me Fredrickson), ka mea e hāʻawi ʻole ai ka lāʻauʻai i ka hopena kūpono, e hōʻemi. Nia huina naʻokoko a me ka LDL-C i loko o nā mea maʻi me ka homozygousʻohana hypercholesterolemia, ka wāʻai Inc a me nā 'ole-pharmacological kūlana kanaka i lawa pono ole.

Ke ʻano o ka noi

Ma mua o ka koho ʻia Atomax Pono ka mea maʻi e ʻōlelo i kahi meaʻai lipid-hoʻemi haʻahaʻa, nāna e hoʻomau e hahai ma hope o ka manawa o ka mālama ʻana.
ʻO ka ma mua mau ka awelika o 10 mg 1 mau lā / lā. Hoʻololi nā ʻōhua mai 10 a 80 mg 1 mau lā / lā. Hiki ke kiʻi ʻia ka lāʻau i kēlā me kēia manawa o ka lā me ka meaʻai a me ka ʻole o ka manawa ʻai. Koho ʻia ka ʻōkole me ka lawe ʻana i nā pae mua o LDL-C, ke kumu o ka lāʻau a me ka hopena pilikino. I ka hoʻomaka ʻana o ka hoʻōla a me / a i ka manawa o ka hoʻonui ʻana i ka mahele o ka Atomax, pono ia e nānā i nā pae lipid plasma a i nā wiki he 2 mau minamina a hoʻoponopono i kēia mau ʻōlelo ma muli.
Ma ka hypercholesterolemia mua a me ka hyperlipidemia hui ʻia, ma ka hapa nui, ʻo ke koho ʻana o Atomax ma kahi pāʻālua o 10 mg 1 manawa / lā ua lawa. Hoʻomaopopo ka hopena therapeutic koʻikoʻi ma hope o 2 mau pule, ma ke ʻano he kānāwai, a me ka hopena therapeutic ākea e nānā pinepine ʻia ma hope o 4 wiki. Me ka lōʻihi o ka mālama ʻana, hoʻomau kēia hopena.
ʻO ka hoʻohana ʻana o ka lāʻau lapaʻau i nā mea maʻi me ka hiki ʻole o ka maʻi a me ka maʻi ʻōpiopio ʻaʻole i hoʻopilikia i ka pae o ka atorvastatin i loko o ke kaila koko a i ʻole ka pae o ka hōʻemi i loko o ka manaʻo o LDL-C i ka wā e hoʻohana ai, no laila, ʻaʻole koi ʻia kahi hoʻololi.
Ke hoʻohana ʻia nei i ka lāʻau lapaʻau i nā mea maʻi ma waena o nā ʻōpiopio, ʻaʻohe ʻokoʻa i ka palekana, ka pono a me ka loaʻa ʻana o nā pahuhopu o ka lipid-lowing therapy i hoʻohālikelike ʻia me ka lehulehu.

Pehea e lawe ai i ka Atomax me ka cholesterol?

ʻO ka lāʻau lapaʻau ma ke ʻano o nā papa. Ua hileiki nā ʻaoʻao o lākou, he palupalu nā ʻāina. Ma kekahi ʻaoʻao aia kahi pilikia. Loaʻa lākou i ka pūlepa hāmeʻa, i hiʻohiʻona ʻia e kahi ʻula keʻokeʻo. Hoʻopili ʻia nā papa ma nā palaka, kahi i hōʻailona ʻia i loko o kahi pahu pepa.

mea kūlohelohe (wae waiwai), aia ia atorvastatin,
ʻano keʻa mahina
kalaka
lactose
povidone
sodium polio
wai silika
poululi colloidal dioxide,
crospovidone.

He aha ka pena o nā papa i hana ʻia? Mai ka triacetin, talc pure, primmeloza, titanium dioxide.

Pehea e inu ai i ka Atomax, nā ʻōlelo no ka hoʻohana ʻana o ka mea i loaʻa i loko o nā paʻi, pono e ʻike nā mea a pau. He hopena palama ia a lipid, ʻo ka hana a ke kuhi nei e hoʻohiolo ai i ka cholesterol, e hoʻopilikia i ka kino o ke kanaka. E pili ana i nā pūʻulu o statins. Eia nō hoʻi, ʻo ka lāʻau lapaʻau he mea mālama hoʻokūkū koho hoʻokūkū o HMG-CoA reductase. Hoʻohana ʻia no kahi kuleana ʻē aʻe: hoʻohaʻahaʻa i nā lipoproteins plasma. Loaʻa i ka atomax ka hopena maikaʻi loa ma nā lipoproteins haʻahaʻa haʻahaʻa ma ka papa o nā ʻāpana o nā ate.

I ka hopena o ka mālama ʻana, ua hoʻomau ʻia ka hoʻomau mau ʻana i ka hana o nā mea LDL e nānā nei. I mea e hoʻomaopopo ai i ka emi iki o ka ulu ʻana a me ka loaʻa ʻana o nā hoʻopiʻi o ischemia.

ʻAʻohe hopena maikaʻi o ka lāʻau kino i ke kino.

I ka manawa e kali ai i ka hopena? I mea e ʻike ai i nā loli maikaʻi, pono ʻoe e lawe i nā panila no ka liʻiliʻi loa 2 mau pule. Pono e hoʻohana ʻia ka lāʻau lapaʻau i hoʻokahi mahina mai ka hoʻomaka ʻana o ka ʻoihana. Ma hope o ke kau ʻana o ka papa, e ʻike ʻia ka hopena.

Nā hōʻailona no ka hoʻohana ʻana. La Atomax i oleloia i na hihia e like me:

Kālā kolamu nui.
Hoʻohui nui LDL-C ka paʻaʻana.
ʻO ka hoʻonui i kāu thyoglobulin a me apolipropylene B.
Inā hoʻonuiʻia ke kiʻekiʻe o ka serum TG.
I ka hihia inā ulu nā dysbetalipoproteinemia i ulu.

ʻAʻole maikaʻi ʻo Atomax inā ʻaʻole hahai ka mea maʻi i ka meaʻai kūikawā i kauoha ʻia e ke kauka. ʻO kēia lāʻau lapaʻau he mea kōkua a hana pū me ka hoʻopili kūikawā.

Pehea e lawe ai a he aha ka make o ka lāʻau lapaʻau? Ma mua o ka hoʻomaka ʻana i ka papa o ka mālama ʻana, pono e maʻi ka mea maʻi i kahi meaʻai lipid-hoʻoliʻa kūikawā. Hoʻomaopopo nā kauka i nā ʻolima no kēlā me kēia maʻi. Hiki ke kiʻi ʻia ka lāʻau lapaʻau ma mua o, ma hope, a ma mua o ka papaʻaina i kēlā me kēia manawa o ka lā. ʻO ka hopena o ka lāʻau lapaʻau mai kēia mea ʻaʻole e emi.

Pehea ka launa ʻana o Atomax me nā lāʻau ʻē aʻe? I ka hihia a hoʻohana ʻia ka lāʻau me ka hui pū me ka erythromycin a me nā mea antifungal, hiki i nā hopena ʻaoʻao i ke ʻano o ka myopia. ʻAʻole pono e hoʻohana ʻo Atomax i ka hana me nā hoʻopiʻi i loaʻa ka hydroxide i alumini, inā ʻaʻole i emi iki ka manaʻo o ka atorvastatin i ke koko a me ka hopena o ka lapaʻau, ʻokoʻa.

Hiki ke hoʻohana ʻia Terfenadine, ʻoiai ka lāʻau lapaʻau i ka nīnau lā i kēia lā ʻaʻole e hoʻololi i nā waiwai o ka mea mua. Hiki iā ia ke hoʻohana pū me ka estrogens - ʻaʻohe mea koʻikoʻi e hānai.

ʻAʻole i kūaeʻa iā Warfarin a me Cimetidine.

Mai hoʻohana me nā inhibitor protease, no ka mea, e hoʻohui i kēia hui i ka paʻa o nā mea ikaika o Atomax. Pono ia e hoʻokaʻawale i nā mea pale, a e hōʻemi paha i ka dosage. Pono e hana ʻia kēia ma lalo o ka nānā ʻana o nā kauka.

Nā Hoʻohui

Nā maʻi hoʻohālikelike i ka hoʻohana ʻia ʻana o ka lāʻau lapaʻau Atomax ʻo: nā maʻi o ka puʻuwai a i ʻole ka hoʻonui ʻana i ka hana o nā transaminases serum (ʻoi aku ma mua o 3 mau manawa i hoʻohālikelike ʻia me VGN) o ka kumu ʻike ʻole, ka hapai, ka lactation, makahiki mai lalo o 18 mau makahiki (ʻaʻole i hoʻokumu ʻia ka ikaika a me ka palekana), hypersensitivity i nā māhele o ka lāʻau lapaʻau.
Hoʻohana me ka mālama aka i ka palaka palaleka, me ka mōʻaukala o ka maʻi ʻeha, ka hōʻemi ʻana o ka electrolyte koʻikoʻi, ka endocrine a me ka maʻi metabolic, hypotension arterial, maʻi nui aʻeha huehue (sepsis), epilepsy paʻa ʻole, hoʻopuka nui, ʻeha, a me nā maʻi ʻeha hooneʻe.

Kahawai

Atomax contraindicated no ka hoʻohana ʻana i ka wā hāpai a me ka lactation (umauma maʻi).
ʻAʻole i ʻike ʻia inā excreted i ka atorvastatin i loko o ka waiū umauma. Hāʻawi i ka hiki ke hanana ʻino loa i nā pēpē, inā pono, hoʻohana i ka lāʻau lapaʻau i ka wā lactation e hoʻoholo i ka hoʻopau ʻana o ka ʻōpū.
Pono nā wahine o nā makahiki hānau hānau i nā ala kūpono o ka contraception i ka wā mālama. Hiki ke kuhikuhi ʻia ʻo Atorvastatin i nā wahine o ka hānau ʻana inā he haʻahaʻa loa paha ka hiki ʻana o ka hapai, a haʻi ʻia ka mea maʻi e pili ana i ka hiki ke kūpono no ka mālama ʻana i ka pūpū.

Hoʻopili pū me nā lāʻau ʻē aʻe

Eia nō naʻe, ʻoi aku ka hopena o ka lipid-hoʻemi ʻana i ka hui o ka atorvastatin a me colestipol i kēlā me kēia pālolo.
Me ka hoʻokele mau ʻana o ka digoxin a me atorvastatin ma kahi maʻa o 10 mg, ʻaʻole i loli ka nui o nā kūhelu waiwai o ka digoxin i loko o ke koko koko. Eia naʻe, i ka manawa i hoʻohana ʻia ka digoxin i hui pū me ka atorvastatin ma kahi maʻa o 80 mg / lā, hoʻonui ʻia ka ʻike o ka digoxin ma kahi o 20%. ʻO nā maʻi e loaʻa ana i ka digoxin i hui pū me ka atorvastatin e pono e nānā.
Me ka hana like o ka atorvastatin a me ka erythromycin (500 mg 4 mau manawa / lā) a i ʻole clarithromycin (500 mg 2 mau manawa / lā), ka mea e kāohi ana i ka CYP3A4, he piʻi nui ka piʻi ʻana o ka plasma o ka atorvastatin i nānā.
Me ka hana like o ka atorvastatin (10 mg 1 manawa / lā) a me azithromycin (500 mg 1 manawa / lā), ʻaʻole i loli ka ulu ʻana o ka atorvastatin i loko o ke koko koko.
ʻAʻohe hopena koʻikoʻi ʻo Atorvastatin i ka paʻa ʻana o ka terfenadine i loko o ke kaila koko, aia ka mea nui i ka metabolly e CYP3A4; i kēia hana, ʻaʻole hiki i ka atorvastatin ke hana koʻikoʻi i ka pākuʻi pharmacokinetic o nā substrat CYP3A4 ʻē aʻe.
Me ka hana like o ka atorvastatin a me ka ulu o ka waha e loaʻa ana i ka norethindrone a me ka ethinyl estradiol, he ulu nui loa i ka AUC o norethindrone a me ka ethinyl estradiol i nānā ma kahi o 30% a 20%, ma kēlā. Pono e noʻonoʻo ʻia kēia hopena ke koho ʻana i kahi contraceptive ā waha no ka wahine e loaʻa ana i ka atorvastatin.
ʻAʻole i ʻike maka ʻia nā pili pōʻino koʻikoʻi o ka atorvastatin me nā estrogens.
Ke aʻo nei i ka hoʻopili ʻana o ka atorvastatin me warfarin a me cimetidine, ʻaʻohe i ʻike nui ʻia o nā maʻi lapaʻau.
Me ka hana like o ka atorvastatin ma kahi maʻa o 80 mg a me amlodipine ma kahi pākahi o 10 mg, ʻaʻole i loli ka hopena pharmacokinetics o atorvastatin i ke kīʻaha kūʻai.
ʻO ka hoʻohana kūpono ʻana o ka atorvastatin me nā inhibitor protease i kapa ʻia ʻo CYP3A4 inhibitors ua hele pū ʻia me ka hoʻonui o ka hiki ʻana o ka plasma o atorvastatin.
ʻAʻole i ʻike ʻia i nā hopena pōʻino koʻikoʻi o ka atorvastatin a me nā mea antihypertensive.

E hoʻokuʻu i ke ʻano a me ka ʻano

ʻO ka Atomax kahi lāʻau lapaʻau e kuhikuhi ana i ke kāohi ʻana i ka hoʻōla ʻia o HMG-CoA, ka hopena o ka hōʻemi ʻana i ka synthesis o kolesterol i loko o nā puʻuwai. ʻAʻole e like me nā statins o ka hanauna mua, ʻo Atomax ka lāʻau lapaʻau o ke kumu synthetic.

Ma ka mākeke farmacological, hiki i kekahi ke loaʻa i ka lāʻau lapaʻau i hana ʻia e ka hui India HeteroDrags Limited a me nā mea kanu o OJSC NIZHFARM, ʻo LLC Skopinsky Pharmaceutical Plant.

Loaʻa ka atomax i ke ʻano o nā papa keʻokeʻo e puni ana i ka ʻaoʻao me ka ʻaoʻao convex. Mai luna mai ua uhi ʻia lākou me ka membrane kiʻi.ʻO ka pūpū hoʻokahi he 30 papa.

Aia i ka papa papa he 10 a 20 mg paha o ka waiwai ikaika - atorvastatin calcium trihydrate.

Eia kekahi ma kahi o ka māhele nui, aia kēlā me kēia papa a me kāna ʻili i kekahi nui.

sodium polio
pauku talcum pauma
lactose manuahi
konekena stearate,
ʻano keʻa mahina
kalaka
povidone
kaomi silika
crospovidone
triacetin

Eia kekahi, ʻo kekahi hapa o ka carbon Titanium e komo i ka hoʻomākaukau.

Ka hana o ka hana o ka hana ikaika

E like me ka mea i hōʻike mua ʻia, ʻike ʻia ka hopena lipid-hoʻemi ʻia o Atomax ma ka pale ʻana i ka hoʻoneʻe ʻia o HMG-CoA. ʻO ka pahuhopu nui o kēia enzyme e hoʻohuli ai i ka methylglutaryl coenzyme A i ka wa mevalonic acid, kahi o mua o ka cholesterol.

Hoʻopili ka Atorvastatin i nā selika mahele, e hoʻohaʻahaʻa ana i ka nui o ka LDL a me ka hana kolamu. Hoʻohana pono ia e nā poʻe maʻi e loaʻa ana i ka hypercholesterolemia homozygous, ʻaʻole hiki ke mālama ʻia me nā lāʻau ʻē aʻe e hoʻohaʻahaʻa i ka cholesterol. ʻO ka dinamika o ka emi ʻana o ke kaohi o ka kolamu e hilinaʻi pono ana i ka hopena o ka mea nui.

ʻAʻole ʻōlelo ʻia ʻo Atomax e lawe ʻia i ka wā o kahi pāʻina, me ka ʻai ʻai liʻiliʻi i ka helu o ka heʻe ʻana. Hoʻopili maikaʻi ka mea hoʻonoina i ka digestive tract. ʻO ka ʻike nui loa o ka atorvastatin e mālama ʻia i nā hola 2 ma hope o ka noi.

Ma lalo o ka mana o nā enzyme CY a me CYP3A4, e hoʻoulu ai ka hana metabolism i loko o ke ate, ma muli o kahi i hana ai ka metabolite parahydroxylated. A laila weheʻia nā metabolites mai ke kino me nā hua bile.

Nā hōʻailona a me nā contraindications no ka hoʻohana ʻana o ka lāʻau lapaʻau

Hoʻohana ʻia ʻo Atomax e hoʻohaʻahaʻa i ka cholesterol. Kūkulu ke kauka i kahi lāʻau lapaʻau i hui pū me ka mea ʻai meaʻai no kēlā me nā maʻi e like me ka papa nui, heterozygous familial a me ka non-familial hypercholesterolemia.

Ua hoʻohana pono ʻia ka hoʻohana ʻana i nā papa no ka nui o ka nui o ka serum o kāuroglobulin (TG), i ka wā e lawe ʻole ai ka lāʻauʻai i nā hopena i makemake ʻia.

Hoʻopili maikaʻi ʻo Atorvastatin i ka cholesterol i loko o nā mea maʻi me ka hypercholesterolemia homozygous homozygous, i ka wā ʻole ka lapaʻau ʻana ʻole i ka lapaʻau ʻana a me ka meaʻai i hoʻopaʻa ʻole i ka molaki lipid.

Ke papa ʻia ʻo Atomax no kekahi mau maʻi o nā maʻi. Aia ke aʻo i kahi papa inoa o nā contraindications no ka hoʻohana ʻana i ka lāʻau lapaʻau.

ʻO nā keiki a me nā wā'ōpiopio ma lalo o nā makahiki 18.
ʻO ka wā hānau o kahi keiki a me ka umauma.
Hewa ʻole o ka Hepatic ma kahi o kahi kumu i ʻike ʻole ʻia.
Hypersensitivity i nā ʻāpana o ka huahana.

ʻO ka lāʻau lapaʻau e kuhikuhi ʻia me ka mālama nui ʻana i ka hihia o ka hypotension arterial, kahi helu hōʻemi o nā electrolytes, nā hewa maikaʻi o ka ʻōnaehana endocrine, nā ala ʻimi, nā maʻi kūloko a me ka epilepsy, ʻaʻole hiki ke hoʻokele.

Nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau

ʻO kahi mea nui i ka mālama ʻana i ka Atomax ʻo ka mālama ʻana i kahi meaʻai kūikawā. Hoʻokumu ke olakino i ka hōʻemi ʻana i ka hoʻokomo o nā meaʻai i loaʻa ka cholesterol kiʻekiʻe. No laila, wehe i ka papaʻai i ka ʻai ʻana o ka viscera (kaʻili, nā palolo), hua yolks hua, pata, ka momona puaʻa, etc.

ʻO ka hapa o ke atorvastatin e like me 10 a 80 mg. Ma ke kānāwai, ke kauka nei ke kauka kau i kahi pualikua mua o 10 mg i kēlā me kēia lā. Hoʻokomo ʻia kekahi mau mea i ka nui o ka lāʻau o ka lāʻau, e like me ka pae o LDL a me ka kolamu piha, nā pahuhopu o ka mālama a me kona pono.

ʻO ka hoʻonuiʻana i ka dosage hiki ke lawe ʻia ma hope o 14-21 mau lā. I kēia hihia, kauoha ʻia ka ʻike ʻana o nā lipids i ka plasma koko.

Ma hope o 14 mau lā o ka mālama ʻana, ʻike ʻia kahi emi ʻana o ka pae o ka cholesterol, a ma hope o 28 mau lā he hopena nui ka hopena therapeutic. Me ka hoʻomehana lōʻihi, hoʻi ka lipid metabolism i ka maʻamau.

Pono e mālama i ka pōpoki o ka lāʻau i loko o kahi e pale ʻia mai ka mālamalama kūpono i ka liʻiliʻi o nā keiki liʻiliʻi. Hoʻohālikelike ke ʻano o ka mālama ʻana o ka mahana mai 5 a 20 degrees Celsius.

ʻO ka ola o kaʻola he 2 mau makahiki, ma hope o kēia manawa ke pāpā ʻia ka lāʻau lapaʻau.

Hoʻolilo kūlohelohe a me ka overdose

Ke kāohi pilikino ʻana i ka lāʻau no ka lāʻau lapaʻau paʻa paʻa loa.

ʻO kekahi manawa, hiki i kahi lāʻau lapaʻau ke hōʻeha i nā hopena ʻino i ka mea maʻi.

Ma mua o ka hoʻohana ʻana i ka Atomax, pono ʻoe e kamaʻilio i kāu kauka.

Ke hōʻike nei ka pauku aʻo i ka hiki ke loaʻa i kēlā ʻano hopena.

Nā hemahema o ka pūnaehana nū nui: aseweic syndrome, hiamoe maikaʻi a hiamoe ʻole, pōkole, pōmoli, amnesia, maʻi ʻeha, hōʻeha, ka puʻuwai, tinnitus, pilikia pilikia, paresthesia, neuropathy peripheral, ʻāhaʻohaʻe, ʻeha maloʻo.
ʻO nā hopena pili i nā hui sensory: ka hoʻomohala ʻana o ke kuli, ka kohu conjunctiva.
ʻO nā pilikia o ka pūnaʻi cardiovascular me ka hematopoietic: phlebitis, anemia, angina pectoris, vasodilation, orthostatic hypotension, thrombocytopenia, hoʻonui i ka holo o ka naʻau, arrhythmia.
ʻO ka hoʻoneʻe ʻana o ka pānaʻi huina a me nā ʻōnaehana biliary: constipation, diarrhea, nausea a me ka luaʻi, ka ʻōpū o ka ʻōpū, he colatic hepatic, belching, heartburn, hoʻonui i ka hoʻokumu ʻana i ka maʻi, ka pancreatitis kiʻekiʻe.
Hōʻike mau i ka ʻili: ka ʻūhā, ka ʻū, ka eczema, ka keʻa ʻana o ka maka, ka photosensitivity.
ʻO nā pilikia o ka ʻōnaehana musculoskeletal: nā mākaʻi o ka ʻōpū o nā haʻahaʻa haʻahaʻa, ʻeha i ka hōʻeha ʻana o nā ʻili a me ke kua, myositis, rhabdomyolysis, arthritis, exacerbation of gout.
Maʻa urination: hoʻopili ka urination, cystitis.
Ka hoʻoholoʻana i nā ʻāpana kaulike: hematuria (koko i loko o ka urine), albuminuria (protein i loko o ka urine).
Nā kumuwaiwai ʻē aʻe: hyperthermia, hoʻemi i ka makemake moekolohe, erectile dysfunction, alopecia, ka momona nui, seborrhea, stomatitis, kaomi kuihuna, rectal, vaginal a me nā wahaebleeds.

ʻO ka lawe ʻana i nā dosis kiʻekiʻe o ka atorvastatin hoʻonui i ka hopena o ka hina ʻana, a me ke myopathy (maʻi neuromuscular) a me ka rhabdomyolysis (ka palena nui o ka myopathy).

I kēia lā, ʻaʻohe ʻano antidote kūikawā no kēia lāʻau lapaʻau.

Inā loaʻa nā hōʻailona o ka overdose, pono lākou e hoʻopau. I kēia hihia, ʻaʻole maikaʻi ka hemodialysis.

Hoʻopili pū me nā lāʻau ʻē aʻe

Hiki i nā mea ikaika ke hana i nā mea lapaʻau i waena o lākou iho, i kahi hopena i hiki ke hoʻoikaika ʻia ai ka nāwaliwali ka hopena therapeutic o Atomax.

ʻO ka hiki ʻana ke launa ma waena o nā mea like ʻole o nā lāʻau like ʻole e pono i ka mea maʻi i hōʻike i ke kauka e pili ana i ka lawe ʻana i nā lāʻau e pili ana i ka hana Atomax.

I nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i ka lāʻau hypolipidemic, ua piha ka ʻike e pili ana i ka pai ʻana me nā lāʻau lapaʻau ʻē aʻe.

Hoʻohui ʻia ka mālama ʻana me ka cyclosporine, erythromycin, fibrates a me nā ʻenehana antifungal (kahi hui o azoles) e hoʻonui i ka hōʻeha o ka pathology neuromuscular - myopathy.
I ka wā o ka noiʻi, ʻaʻole ʻo ka lawelawe like ʻana o Antipyrine i ka loli nui i ka pharmacokinetics. No laila, ua ʻae ʻia ka hui ʻana o nā lāʻau ʻelua.
ʻO ka hoʻokaʻawale ʻina o nā suspensions e loaʻa ana i ka ʻenekena sela magnesium a i ʻole alumina hydroxide e alakaʻi i ka emi ʻana o ka ʻike o ka atorvastatin i ka plasma.
ʻO ka hui pū ʻana o ka Atomax me nā paila mana e hānau ai ka mea liʻiliʻi loa a me ka norethindrone e hoʻonui ai i ka AUC o kēia mau mea.
ʻO ka hoʻohana pinepine ʻana o colestipol e hōʻemi i ke kiʻekiʻe o ka atorvastatin. Ma kēia e hoʻomaikaʻi ai i ka hopena lipid-hoʻohaʻahaʻa.
Hiki i ke Atomax ke hoʻonui i ka digoxin i ke kahawai. Inā pono, ʻo ka mālama ʻana me kēia lāʻau e pono ai ma lalo o ka mākaʻikaʻi ʻana i nā lāʻau lapaʻau.
ʻAʻole pili i ka hoʻokele Parallel o Azithromycin i ka loaʻa mai o ka hana ikaika o Atomax i nā kaila koko.
ʻO ka hoʻohanaʻana o ka erythromycin a me clarithromycin e hoʻonui i ka pae o ka atorvastatin i ke koko.
I ka wā hoʻokolohua hoʻokolohua, ʻaʻohe i ʻike ʻia nā hopena kūlohelohe ma waena o Atomax a me Cimetidine, Warfarin.
Ke hoʻonui nei i ka pae o ka waiwai hana i nānā ʻia me ka hui pū ʻana o ka lāʻau lapaʻau me nā blockers protease.
Inā pono, e ʻae ke kauka iā ʻoe e hoʻohui i ka Atomax me nā lāʻau lapaʻau, ʻo ia hoʻi ʻo Amplodipine.
Nā haʻawina e pili ana i ka pili ʻana o ka lāʻau lapaʻau me nā lāʻau antihypertensive.

Me ka hui pū ʻana o Atomax me nā estrogens, ʻaʻohe hewa i nānā ʻia.

Kumukūʻai, loiloi a me nā kikoʻī

He liʻiliʻi nā ʻike ma ka hopena o ka hoʻohana ʻana iā Atomax ma ka Pūnaewele. ʻO ka mea ʻoi i kēia manawa, ua hoʻohana ʻia nā statins heʻohana ma nā hana lapaʻau. Ke loaʻa nei kēia mau lāʻau i ka dosage maʻamau a ʻaʻole i palena i nā hopena ʻelua.

ʻAʻole paʻakikī ʻo Atomax e kūʻai aku i loko o ka lāʻauʻai i loko o ka ʻāina ma muli o ke ʻano o kēia manawa he aneane ʻole ia. I ka awelika, ʻo ke kumukūʻai o kahi pōpeku (30 mau papa o 10 mg) mau pilina mai 385 a 420 mau rubles. Inā kūpono, hiki ke kauoha ʻia i ka lāʻau ma ka pūnaewele ma ka pūnaewele mana o nā mea hana.

Aia nā loiloi he mau loiloi ma ka lipid-lowering agent ma nā papa kūkā. ʻO ka hapa nui, e kamaʻilio lākou i ka ulu ʻana o nā hopena ʻino aʻo ka lawe ʻana i ka lāʻau. Eia nō naʻe, ʻokoʻa nā manaʻo like ʻole.

Ma muli o nā ʻano like ʻole contraindications a me nā hopena maikaʻiʻole, i kekahi manawa ke kahakaha nei ke kauka i kahi synonym (kahi lāʻau me ka mea like ʻole like ʻole) a i ʻole kekahi analogue (e ʻano ana i nā ʻokoʻa like ʻole, akā hoʻokō pū kekahi hopena therapeutic like).

Hiki ke kūʻai aku i nā hōʻailona like o Atomax ma ka mākeke lāʻau Lūkini:

Atovastatin (No. 30 ma 10 mg - 125 rubles),
Atorvastatin-Teva (No. 30 no 10 mg - 105 mau rubles),
Atoris (ʻAʻole. 30 no ka 10 mg - 330 rubles),
Liprimar (Helu 10 ma 10 mg - 198 rubles),
Novostat (ʻAʻohe 30 no 10 mg - 310 rubles),
Tulip (ʻAʻole. 30 no ka 10 mg - 235 rubles),
Torvacard (ʻAʻole. 30 no ka 10 mg - 270 mau rubles).

I waena o nā mea kikoʻī kūpono o Atomax, pono ia e hoʻokaʻawale i nā lāʻau lapaʻau:

Akorta (ʻAʻole no 30 no 10 mg - 510 mau rubles),
Krestor (No. 7 no 10 mg - 670 rubles),
Mertenil (No. 30 no 10 mg - 540 rubles),
Rosuvastatin (Helu 28 ma 10 mg - 405 rubles),
Simvastatin (ʻAʻole. 30 ma 10 mg - 155 mau rubles).

Ka nānā pono ʻana i ka lāʻau lapaʻau Atomax, nā ʻōlelo e pili ana i ka hoʻohana ʻana, ke kumukūʻai, ka hoʻohālikelike a me ka manaʻo o nā mea kūʻai aku, ʻo ka mea maʻi, me ka ʻaha hui e hele nei i nā mākaʻikaʻi loiloi i ka pono o ka lawe ʻana i ka lāʻau.

Hāʻawi ʻia ka ʻikepili e pili ana i nā statins i ke wikiō ma kēia ʻatikala.