E kuhikuhi i ka aspart insulin e uku i ka maʻi diabetes

ʻO ka hoʻohana ʻana i nā alapine basal o ka hormone kanaka, ʻaʻole ia e ʻae iā ʻoe e hoʻomalu i ka glycemia o nā maʻi, ʻoi aku hoʻi i ka pō. Ke hele nei ka maʻi, e koi mau ʻia ka hoʻoponopono ʻana o ka nui o ka insulin basal, a he mea nō hoʻi e hōʻeha i kekahi mau pilikia a ʻaʻole ʻae ʻoe i ka kaohi i ka hoʻonui ma glucose ma hope o ka ʻai ʻana.

Nā hewa hewa kūpono e alakaʻi ai i ka holomua o ka maʻi.

I kēia mau makahiki i hala iho nei, ua hoʻomāhuahua nā mea āpau biphasic i loaʻa kahi pōmaikaʻi pōkole a lōʻihi, e like me ke Aspart lua-phase phase. ʻO ka hoʻohanaʻana i kahi hui base-bolus hiki ke maʻalahi i ka mālamaʻana i ka maʻi maʻi, no ka mea e hōʻemi ana i ka nui o nā inikini i kēlā me kēia lā.

Bypasic insulin aspart * (Insulin aspart biphasic *) - Nā hana olakino manawa lōʻihi e loaʻa i ka hoʻohana ʻana i ka ʻenehana DNA recombinant. Hoʻopili pū kekahi me kahi receptor kūikawā ma ka membone cytoplasmic o waho o nā pūpū a hana i kahi mea hoʻohui insulin-receptor e hoʻoikaika i nā hanana intracellular, e komo synthesis o kekahi o nā kīʻaha koʻikoʻi (hexokinase, pyruvate kinase, glycogen synthetase). ʻO ka emi ʻana o ke kaila o ke koko ma muli o ka hoʻonui o kona kaomi intracellular, hoʻonui i ke kūoʻi ʻana a me ka hoʻowalewale ʻana e nā ʻili, hoʻonāukiuki i ka lipogenesis, glycogenogenesis, a me ka hoʻohaʻemi ʻana o ka hōʻemi o ka hana glucose ma ka ʻāʻaʻa.

ʻO ka lōʻihi o ka hana o ka hoʻomākaukau ʻana o ka insulin e ʻike ʻia e ka helu o ka ʻimi ʻana, ka mea i hilinaʻi ʻia i nā mea he nui (no ka laʻana, ma ke ʻano, ka ʻoka a me nā wahi o ka hoʻokele), a no laila ua pili ʻia ka pā o ka hana ʻana i ka insulin i ka loli nui, i nā kānaka like ʻole a i ka hoʻokahi kanaka . ^ E Ha yM.

I ka awelika, ma hope o ka hoʻokele sc, hoʻomaka ʻo Rinsulin NPH e hana ma hope o nā hola 1,5, e ulu ka hopena kūpono loa ma waena o 4 mau hola a me 12 mau hola, ʻoi aku ka lōʻihi o 24 mau hola.

ʻŌpū a me ka lactation

Ua hōʻike ʻia nā haʻawina holoholona me nā mea pili o ka insulin aspart a me nā manuahi kanaka maʻamau i nā ʻōpala iʻoi aku ma mua o ka ʻōlelo no ka hoʻokele sc i loko o nā kānaka ma kahi o 32 mau manawa (nā kīlio) a me 3 mau manawa (nā ʻolike), ʻelua ona insulin i hana a me ka nalowale o ka post-implantation, a me nā mea pono a visceral / skeletal.

ʻAʻole i mālama ʻia nā haʻawina kūpono a paʻa i ka wahine hāpai. Pono e nānā pono a me ka nānā pono ʻana i ka glucose koko i ka wā o ka wā hiki a hiki i ka wā hapai a ma ka manawa o kona wā holoʻokoʻa ʻelua ma nā mea maʻi me ka maʻi mellitus a me nā wahine me ka mōʻaukala o ke ʻano maʻi gestational.

Ka pono o ka insulin, ma ke ʻano he kānāwai, e ho'ēmi i ka trimester mua o ka hāpai ʻana a hoʻonui i loko o ka lua - ke kolu ʻo ka trimesters. I ka wā a ma hope o ka hānau ʻana, hāʻule paha nā koi o ka insulin.

ʻO ka māhele FDA o ka hana no ka pūpū ʻo C.

Hoʻohui ka ʻike ʻoihana maʻi ma ka wā o ka lactation. Hoʻohana me ka akahele (ʻaʻole i ʻike ʻia inā excreted i ka ʻekena insulin i ka waiū umauma).

ʻO ka hoʻohana ʻana o ka hui ʻana o ka insulin aspludec insulin aspart i ka wā hapai ua contraindicated, no ka mea ʻaʻoheʻike olakino me kāna hoʻohana ʻana i ka wā hāpai. ʻAʻole hōʻike nā haʻawina o ka hana reproduction i nā holoholona i ka ʻokoʻa ma waena o ka insulin degludec a me ka insulin kanaka i ka ʻōlelo o ka embryotoxicity a me teratogenicity.

ʻO ka hoʻohana ʻana o ka hui ʻana o ka insulin aspludec insulin aspart i ka wā o ka umauma i contraindicated, no ka mea ʻAʻoheʻike loea ma ka wahine lactating.

Ua hōʻike ʻia nā haʻawina holoholona i nā nāu, ka hoʻōla ʻia ʻana o ka insulin degludec ma ka umauma umauma, ʻoi ka haʻahaʻa o ka waiū umauma ma lalo o nā kaila koko. ʻAʻole maopopo ʻia inā ua excreted ka insulin degludec i loko o ka umauma waiū o nā wahine.

Pūnaewele. ʻAʻole i ʻike ʻia nā haʻawina holoholona i nā hopena maikaʻi loa o ka insulin degludec i ka ulu hua.

ʻO ka māhele FDA o ka hana no ka pūpū ʻo C.

ʻO ka lawa ʻana a ʻike paʻa ʻia i ka hoʻohana ʻana i ka hoʻohana ʻana i ka hui ʻana o ka insulin aspludec insulin aspart i nā wahine hāpai ʻaʻole i hana ʻia. Ke hoʻolālā nei i kahi hapai a hoʻonohonoho paha iā ia, pono ke kamaʻilio e kamaʻilio me ka hoʻohana ʻana i nā lāʻau lapaʻau me kā lākou kauka.

No ka hiki ʻole o ka noi ʻana i nā holoholona hoʻoulu i nā hopena i loko o nā kānaka, e pono e hoʻohana ʻia ka hui ʻana o ka insulin degludec insulin aspart i ka wā hapai inā he hopena kūpono paha ka hopena o ka maʻi maʻi.

No nā mea maʻi me ka mōʻaukala o ka maʻi maʻi a i ʻole ka maʻi gestational, e mālama ana i ka kaohi metabolic maikaʻi ma mua o ka ʻāʻī ʻana a i ka wā hāpai ka mea nui. Hiki i ka insulin ke hoʻemi i ka wā o ka trimester mua o ka hāpai ʻana, ma ke ʻano he kānāwai, e hoʻonui ana i ka wā o ka trimesters lua a me ke kolu o ka hoʻohemo ʻana ma hope o ka hānau ʻana.

ʻO ka mālama pono ʻana i nā pae glucose i mea nui loa i kēia mau maʻi.

ʻAʻole i ʻikea a excreted i ka ʻenemi degludec / aspart i loko o ka waiū umauma. No ka mea, he nui nā mea e komo ai ka insulin kanaka, e hoʻokaʻawale i ka waiū umauma, e pono e hoʻomaʻamaʻa ʻia i ka wā e hoʻohana ai i ka hui ʻana o ka insulin degludec insulin aspart i nā makuahine hānai. ʻO nā wahine me ka maʻi diabetes i ka wā lactation hiki ke koi i kahi loli i ka nui o ka insulin, e hana ʻia ai ka hoʻolālā ʻana, a i ʻole ʻelua.

I nā noiʻi holoholona, ​​hōʻike ʻia me ka hoʻomaka ʻana o ka aspart insulin a me ka insulin kanaka maʻamau i nā pehu ma mua o ka nui i ʻōlelo ʻia no ka p / quota i nā kānaka e pili ana i ka 32 mau manawa (nā kahelehe) a me 3 mau manawa (nā ʻolē), nā insulin i hana mua i post-implantation nalowale, a me ka lawehala visceral / kalaiwa.

ʻO ka māhele FDA o ka hana no ka pūpū ʻo C.

Nā hōʻike a me nā kumukūʻai

Loaʻa ka lāʻau lapaʻau Novomix Flekspen i ke ʻano o ka peni syringe me kahi mea i hoʻomākaukau ʻia no ka pākahi hoʻokahi. Aia nā 5 syringes i ka pākaukau. ʻO ke kumukūʻai mai 1559 rubles. Aia nā inoa Novomiks Flekspen i kahi hōʻailona helu like ʻole: 30, 50, 70. Ua like lākou me ka helu o nā Asparts i nā huaʻōlelo.

ʻO ke kumukūʻai o Novorapid Penfill ma waena o 1670 a 1900 mau rubles no ka pāleke.

ʻO nā keiki ma lalo o 6 mau makahiki (kahi palekana a ʻaʻole pono i hoʻoholo ʻia).

S / c, ma ka paia ʻōpū, ʻūhā, poʻohiwi a poki paha, ma mua koke o ka ʻai (prandial) a i ʻole ma hope o ka ʻai (postprandial). Pono nā hoʻololi o nā pūnaewele injection i loko o ia wahi like o ke kino.

Hoʻoholo kū hoʻokahi ka ʻākā a me ke ʻano o ka hoʻokele. ʻO ka mea pono no ka insulin e maʻamau ka maʻi 0.5-1-1 PIECES / kg / lā, a ua hāʻule ka 2/3 i ka prandial (ma mua o ka ʻai) insulin, 1/3 - ma ka basal (background) insulin.

I loko / / (inā pono), e hoʻohana ana i nā ʻōhua infusion. Ma loko o / i ka hoʻomaka i hiki ke lawe ʻia e nā limahana lapaʻau mākaukau.

Hoʻopiʻi i nā pākeke.

E hana ʻia nā ʻikepili hana kūʻokoʻa wale nō (ma ka waiho ʻole ʻana o nā ʻōlelo kikoʻī mai ke kauka hele mai. Hiki iā ʻoe ke hoʻokomo i ka hāmeʻa ma kekahi o kēia mau wahi:

1. ʻO ka pa
2. ʻEha
3. Buttock
4. I kekahi mau manawa, i ka poʻohiwi.

Hiki iā ʻoe ke hoʻohana i ka hana i ke kali ʻana ma mua a ma hope o ka ʻaina. Pono e mālama ʻia kahi manawa i kēlā me kēia wahi i kahi hou (i loko o ka pā o ka māhele o ke kino - poʻohiwi, ʻōpū, ʻōpū).

Ka helu ʻia o ka lāʻau lapaʻau no ka hoʻokele hoʻokahi i helu ʻia e ke kauka. Ka pono no ka insulin i kēlā me kēia mea maʻi ke kū hoʻokahi a hilinaʻi i nā mea he nui - ke kaupaona, ka makahiki, ke kūlana o ke olakino.

Nā Hoʻohui

ʻO nā hoʻohālikelike e hōʻike ana i ka hiki ʻole o ka hoʻohana ʻana i ka lāʻau o Aspart he liʻiliʻi loa. Hoʻohui lākou i ka hoʻonui ʻia o ka mahele, a me ka hypoglycemia hoʻi. Kahi ʻia nā hihia i ka wā e palena ʻia ai ka ʻai - he makahiki kēia a ke keiki a hiki i ʻeono makahiki.

I nā hihia āpau e loaʻa, ʻo ka Aspart insulin ka mea maikaʻi loa a me ka hopena e kōkua ai e mālama i ka maʻi maʻi ma kahi pae olakino kūpono loa. Eia naʻe, no kēia mea he mea pono e hoʻomanaʻo i nā ʻōlelo i hāʻawi ʻia i luna.

Hoʻohana ʻia ka Bypasic insulin Aspart (kahi mea kikoʻī o Flexpen) i ka mālama ʻana i ka ʻano type type 1 a me ke ʻano type type 2 mellitus inā ua hala ia i ka insulin-depend phase.

ʻAʻole hoʻohana ʻia ka lāʻau me ka intolerance pilikino i kāna mau ʻāpana a me ka hoʻonui ʻana iā lākou. ʻAʻole i noiʻi ʻia ka noi ʻana i nā keiki i lalo o ke 6 mau makahiki o laila, no laila, ʻaʻole pono ke noi ʻia e hoʻohana i kekahi o ko lākou mau ʻelele i kēia makahiki.

Hoʻohana ʻia ka hoʻohana ʻana i ka hāpai ʻana. ʻAʻole i hoʻokō ʻia nā hoʻokolohua piha. Pili ka like me ka FlexPen a me Novorapid Penfill. Akā i loko o nā haʻawina ʻelua o ka lāʻau Novorapid Penfill ma nā wahine hāpai, ʻaʻohe data i loaʻa i ka hopena maikaʻi ʻole o ka waiwai ma ka hāpai ʻana a me ke ʻano o ka pēpē.

Hiki i nā makuahine kahu maʻi ke hoʻohana i ka insulin i ka nui o ka pono, ʻaʻole ia e pili i ke keiki. Pono paha e hoʻoponopono i ka ʻōpū no ka makuahine.

Hōʻike ka hoʻonāukiuki i ke ʻano o ka hana nui a ka hormone. ʻO ke kūlana o ka hypoglycemia i ka wā e hoʻohana ai i ka lāʻau biphasic e ulu pinepine i ka hanana pinepine ma mua o ka regimen dosage maʻamau.

Hōʻike ʻia kēia ʻanoʻano ʻino ʻekena:

• Urticaria, rashes ʻili, līkuhi - hoʻoiho kūloko.
• ʻO ka neuropathy peripheral.
• ʻO nā maʻi hōʻemi (ʻoi aku ka hoʻomaka i ka hopena), retinopathy.
• Lipodystrophy ma ka wahi ʻōlelo.
• Nā kūloko o ke kūloko ma nā wahi o ka ʻoihana.

Ke lawe nei i kekahi mau lāʻau lapaʻau me ka piʻi ʻana o ka hopena Aspart a me ka hiki ke hoʻomohala ʻana i ka hypoglycemia:

• Nā maʻi hoʻohālikelike.
• Nā mea hoʻonani o MAO, ACE.
• Hoʻopau.
• Nā diuretaha Thiazide.
• Heparin.

Hiki i ka alakino ke hoʻoikaika a hoʻonāwaliwali i ka hopena o ka mālama ʻana i ka hormonal.

Hoʻonui ka naʻau o kēlā me kēia kanaka, nā keiki ma lalo o ka 18 mau makahiki o ka wā, ka manawa o ka hāpai a me ka umauma (ʻaʻohe manaʻo loiloi me nā keiki, nā wahine i ka wā hāpai a me ka hānai).

Hōʻike ʻia ka Insart aspart no ka mellitus diabetes i hilinaʻi ʻia. ʻO ka maʻamau, kēia ia kahi maʻi o ka ʻano mua a me ke ʻano lua i kēlā mau kūlana i ka wā i hoʻohuli ai ia i kahi ʻano hana i hana ʻia i ka insulin. Ma ke ʻano ʻo ka maʻi āpau 2, ua kuhikuhi ʻia i ka wā e pau ai ka hoʻōla ʻana o ka lāʻau i lawe ʻia ma ke ʻano a i ʻole kekahi hapa nalo.

ʻAʻole kuhikuhi ʻia ka lāʻau lapaʻau no hypersensitivity i kāna hana koʻikoʻi nui (insin insulin) a me nā mea kōkua i ka mea haku. Pēlā pū kekahi contraindication e hoʻohana he mau a i ʻole wā maʻamau ka hypoglycemia. Eia nō hoʻi, ʻaʻole pono e kuhikuhi ʻia nā keiki ma lalo o 6 mau makahiki mai ka wā i mālama ʻia ʻole ai nā hoʻokolohua lapaʻau i kēia ʻano makahiki.

Ke hoʻomau nei ka noi ma ke wā hāpai ʻana, ʻoiai ʻaʻole i lawe ʻia nā haʻawina piha. I ka hoʻolālā ʻana a i ka wā hāpai paha, pono ia e hoʻomaopopo i ka endocrinologist e pili ana i kēia. I kekahi mau hihia, pono ʻoe e hoʻololi i ka lāʻau lapaʻau a kāpae paha i ka hoʻopau ʻana.

Me ka lactation, mālama pū ʻia ʻia. ʻAʻohe mea noiʻi e hōʻike ana inā hōʻiliʻili ka aspartame i ka waiū umauma.

Kahi papa inoa o nā kūmole

E makaʻala! Aia ka papa inoa i nā huaʻōlelo no ka Insulin aspart biphasic * (Insulin aspart biphasic *), he ʻano hui like ʻole, no laila hiki iā ʻoe ke koho i kahi ke kuapo iā ʻoe iho, me ka lawe ʻana i ke ʻano a me ka ʻano o ka lāʻau lapaʻau i kuhikuhi ʻia e kāu kauka.E hāʻawi i ka makemake i nā mea hana mai ka USA, Japan, Western Europe, a me nā ʻoihana maikaʻi loa mai ʻEulopa Hui Pū ʻIa: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Hoʻokahi kekahi kipa i kahi helu intake i kēlā me kēia lā

Ehia mau e lawe ai i ka Insulin aspart biphasic * (Insulin aspart biphasic *)?
ʻO ka hapanui o nā mea pane i lawe i kēia lāʻau lapaʻau i nā manawa 2 i ka lā. Hōʻike ka hōʻike i ka pinepine o nā mea pane e lawe i kēia lāʻau lapaʻau.

Nā lālā	%
2 mau lā i kahi lā	1	100.0%

Ua kipa kekahi kipa i kahi manamana

Nā lālā	%
51-100mg	1

ʻO ka kaomi neʻe o ka glucose ma ke ʻano 1 a me ke ʻano type type 2 he hōʻoiaʻiʻo ʻana e hoʻohemo i ka hoʻomaka ʻana o nā hopena vascular. ʻO ka maʻi Insulin ka mea nui o ka maʻi maʻi no ka maʻi type 1 a me kekahi mau kūlana ke koi ʻia no nā maʻi maʻi type 2 e hui pū me nā lāʻau hypoglycemic. ʻO ka hoʻohanaʻana i nā lāʻau biphasic e hāʻawi i nā hopena maikaʻi.

ʻIkepili lāʻau lapaʻau

ʻO ka hoʻonohonoho o ka insulin Degludek / insulin Aspart e komo me ka 70% o kahi kinona o ka hana superlong (Degludec) a me 30% o ka puʻupuʻu insulin Aspart, kahi i hui pū ʻia i hoʻokahi maʻi. Ma hope o ka hoʻoponopono subcutaneous, hoʻokumu ʻia ka depot hormone, aia nā hexamers o ka mea ikaika. Noho mālie, ma ke ʻano o ka lā, ua hoʻohiolo ka nui o nā molekila Aspart i nā monomers, nā mea i hoʻoulu ʻia i ka wai koko a loaʻa kahi hopena like me ka hormone endogenous.

ʻO Bypasic insulin Aspart e hiki iā ʻoe ke hoʻomalu i ka pae o ka glycemia maikaʻi, ʻoi aku ka nui o ka hypoglycemia ma mua o ke hoʻohana wale ʻana i ka insulin basal a i ʻole mua aʻe o nā biphasic mua.

ʻOi aku ka mea nui ke kaohi o ka glucose i ka pō, no ka mea ke hoʻohana ʻana i ka mākaukau makin konane, hiki mai ka hoʻemi ʻana i ke kōpaʻa koko. A ke kaumaha nei kēia i ka pono o ka poʻe maʻi, hoʻonui i ka ʻeha o ka make koke.

Nā hōʻailona a me nā contraindications

Hoʻohana ʻia ka Bypasic insulin Aspart (kahi mea kikoʻī o Flexpen) i ka mālama ʻana i ka ʻano type type 1 a me ke ʻano type type 2 mellitus inā ua hala ia i ka insulin-depend phase.

ʻAʻole hoʻohana ʻia ka lāʻau me ka intolerance pilikino i kāna mau ʻāpana a me ka hoʻonui ʻana iā lākou. ʻAʻole i noiʻi ʻia ka noi ʻana i nā keiki i lalo o ke 6 mau makahiki o laila, no laila, ʻaʻole pono ke noi ʻia e hoʻohana i kekahi o ko lākou mau ʻelele i kēia makahiki.

No nā keiki i lalo o 6 mau makahiki o ka makahiki, ʻaʻole i ʻōlelo ʻia ka hoʻohana ʻana o Insulin aspart, a me nā wahine hāpai

Hoʻohana ʻia ka hoʻohana ʻana i ka hāpai ʻana. ʻAʻole i hoʻokō ʻia nā hoʻokolohua piha. Pili ka like me ka FlexPen a me Novorapid Penfill. Akā i loko o nā haʻawina ʻelua o ka lāʻau Novorapid Penfill ma nā wahine hāpai, ʻaʻohe data i loaʻa i ka hopena maikaʻi ʻole o ka waiwai ma ka hāpai ʻana a me ke ʻano o ka pēpē.

Hiki i nā makuahine kahu maʻi ke hoʻohana i ka insulin i ka nui o ka pono, ʻaʻole ia e pili i ke keiki. Pono paha e hoʻoponopono i ka ʻōpū no ka makuahine.

Hōʻike ka hoʻonāukiuki i ke ʻano o ka hana nui a ka hormone. ʻO ke kūlana o ka hypoglycemia i ka wā e hoʻohana ai i ka lāʻau biphasic e ulu pinepine i ka hanana pinepine ma mua o ka regimen dosage maʻamau.

Hōʻike ʻia kēia ʻanoʻano ʻino ʻekena:

• Urticaria, rashes ʻili, līkuhi - hoʻoiho kūloko.
• ʻO ka neuropathy peripheral.
• ʻO nā maʻi hōʻemi (ʻoi aku ka hoʻomaka i ka hopena), retinopathy.
• Lipodystrophy ma ka wahi ʻōlelo.
• Nā kūloko o ke kūloko ma nā wahi o ka ʻoihana.

Ke lawe nei i kekahi mau lāʻau lapaʻau me ka piʻi ʻana o ka hopena Aspart a me ka hiki ke hoʻomohala ʻana i ka hypoglycemia:

• Nā maʻi hoʻohālikelike.
• Nā mea hoʻonani o MAO, ACE.
• Hoʻopau.
• Nā diuretaha Thiazide.
• Heparin.

Hiki i ka alakino ke hoʻoikaika a hoʻonāwaliwali i ka hopena o ka mālama ʻana i ka hormonal.

Nā noi noi

Hoʻolālā wale ʻia ka Novorapid Penfill e like me ka subcutaneously, e like me nā lāʻau lapaʻau e loaʻa ai kahi inoa kālepa ʻē aʻe, akā like i ka mana. ʻAʻole hoʻohana ʻo Aspart i ka pohō i ka hoʻohana ʻana no ka hoʻopuʻe ʻana i nā pū o ka insulin.Koho ʻia ka maʻi ma kēlā me kēia hihia i kēlā me kēia.

ʻO ka regimen maʻamau no ke ʻano maʻi type 2 he hoʻokahi ʻauahi ma ke kakahiaka ma mua o ka ʻaina kakahiaka a i ʻole ma hope o a i kaha ʻia ka 6 huina ma mua o ka ʻaina.

Ke hoʻoneʻe ʻia mai nā ʻano lāʻau ʻē aʻe, e mālama pono ana ka mālama ʻana i ke kiʻekiʻe o ka glucose koko.

Hoʻohālikelike

ʻO ke kūleʻa o ka maʻi maʻi kūleʻa wale nō me ka hoʻoponopono kūpono a me kaimenea dosage. Pono e hana ʻia e ke kauka, e pili ana i ka ikepili o ke ana ʻana i ka nui o ke kō i loko o kekahi mau lā. ʻO ka hoʻoponopono kūpono e hōʻemi i nā pilikia o ka hoʻomohalaʻana i nā hōʻeha o ka maʻi a ʻaʻole i hoʻopilikia i ka maikaʻi holoʻokoʻa.

Aia ke olakino a me ke ola o kahi maʻi maʻi i ka koho ʻana o ka insulin kiʻekiʻe kiʻekiʻe. ʻO ka papa lāʻau Insulin he lāʻau lapaʻau kaulana a kūpono hoʻi i hōʻike ʻia e nā kauka. Hoʻohana ʻia ia ma ke ʻano kūlohelohe no kou pono ponoʻī, e lilo ʻole i loko o ke kino a no laila e koi ʻia i ka hoʻomaka ʻana mai waho. Kōkua kēia i ka hoʻomaikaʻi ʻana i ke kūlana o ka mea maʻi a uku i ka maʻi mellitus, me ka hoʻēmi ʻana a me ka helu o ka ulu ʻana o nā ʻōhua kikoʻī.

ʻO ka huahana ikaika ka inoa like (insulin aspart). ʻO kēia ke ʻano o ka loli maʻamau o ke ʻano o ka hana ultrashort. Loaʻa iā ia ma muli o ka hōʻike ʻana i kahi mākēha kūikawā e hoʻohana ana i ka ʻenehana DNA recombinant. I ka hopena, ua hoʻololi ʻia ka prine acid amino i ka acid aspartic.

Kūpono ʻia e like me ka hoʻokuʻu ʻana, mākaukau no ka hoʻokele subcutaneous. Ke keʻokeʻo nei ka pakanā ma ke kala; ma ka hoʻonā ʻia, he ʻano keokeo keʻokeʻo ma lalo a me kahi wai hoʻokaʻawale ma luna o ka pahu. Me ka hoʻohaʻahaʻa ʻana a lulu paha, lilo ka wai i ka homogeneous hou.

Hiki ke ʻano ke kumukūʻai o ka lāʻau lapaʻau ma muli o ka nui o ka lāʻau. I ka awelika, 5 mau kukama o 3 ml kēlā me kēia kumukūʻai e pili ana i ka 1800 - 1900 mau rubles i loko o nā lāʻau lapaʻau ma Moscow.

Aspartame - he aha ia?

ʻO kēia waiwai he mea hoʻohālike i ke kō, momona loa. Ua hana mua ʻia ka huahana ma ke ʻano he 60 o nā kenekulia 20. Loaʻa ia e chemist J.M. Schlatter, kahi mea ma kahi o nā hua o ka hopena e loaʻa , ua loaʻa ka mea ʻai i nā pono hana.

ʻO ka hoʻohuiʻana ma kahi o 200 mau manawa i ʻoi aku ka momona ma mua o ke kō. ʻOiai ka manaʻo o ka mea manamana he mau calorie kikoʻī (e pili ana iā 4 kilocalories no ka grala), e hana ai i kahi momona ʻono o ka waiwai, pono ʻoe e hoʻohui i ka mea ʻoi ka makemake o ka meli. No laila, i ka wā i hoʻohana ai i ka kuke ʻana, ʻaʻole lawe ʻia kāna waiwai caloric. Kūlike ʻia i huehue, ua nui ka hua ʻōlelo hou, ʻoi aku ka moʻo ʻana o ka pīhoihoi.

He aha ko Aspartame, kona mau wahi kino, ka hōʻeha o ka Aspartame

Loaʻa ka waiwai tīnaehana hoʻohuihui methylatedka mea e noho ai ke koena phenylalaninea aloha acid. ^ E Ha yM. Wahi a Wikipedia, ʻo kona molika molipoleka = 294, 3 mau pākēkē o nā mole, ʻo ka uku o ka huahana he 1,35 mau grika pākēnika pākēneka. Ma muli o ke kumu o ka huehue o ka waiwai mai 246 a 247 degere Celsius, ʻaʻole hiki ke hoʻohana ʻia i nā mea momona i hiki ke kau ʻia i ka mālama wela. ʻO ka hoʻohuiʻana i ka solubility maʻalahi i ka wai a me nā mea'ē aʻe. ʻaʻopiʻi paʻā.

Harm of Aspartame

I kēia manawa, hoʻohana ikaika ʻia ka hāmeʻa e like me ka hoʻoweliweli ʻana i nā mea - Aspartame E951.

Ua ʻike ʻia ma hope o ka komo ʻana i ke kino o ke kanaka, pio ke ʻano o loko a me métanolol. ^ E Ha yM. ʻO ka Methanol i nā nui he nui nā mea make. Akā, ʻo ka nui o ka methanol i loaʻa i kahi kanaka i ka wā eʻai ai ka nui ma mua o ka kiʻekiʻe o ka waihona i hoʻoiho ʻia mai ka hemo ʻana o Aspartame.

Ua hōʻoia ʻia he nui ka nui o ka methanol i loko o ke kino o ke kanaka. Ma hope o ka ʻai ʻana i hoʻokahi kīʻaha o ka hua wai huaʻai, he ʻano nui aʻe o kēia pūlea ma mua o ka pau ʻana o ka nui o nā wai inu i ʻāpono ʻia me Aspartame.

Ua hoʻokolohua ʻia nā haʻawina hoʻokolohua a me nā maʻi toxicological i hōʻoia e hōʻoiaʻiʻo ʻole ka mea ʻoluʻolu. I kēia hihia, ua hoʻomau ʻia ka loaʻa ʻana o nā lā i kēlā me kēia lā i ka lāʻau. He 40-50 mg pākaha i ke kaupaona o ke kino i kēlā me kēia lā, ʻo ia ka mea e like me nā papa he 266 o kahi mea hoʻoliʻelima synthetic no kahi kanaka e kaupaona ana i 70 kg.

I ka makahiki 2015, ʻelua hoʻokolokolo hoʻokūkū paʻa kope, i hui ʻia e nā kānaka he 96. I ka hopena, ʻaʻole i loaʻa nā hōʻailona metabola a me nā kumumanaʻo o kahi uaki maikaʻi ʻole i ka mea moʻomeheu maoli.

ʻO Aspartame, he aha ia, pehea ka ulu ʻana o kona metabolism?

Loaʻa ka mea hana i nā protein nui o nā meaʻai maʻamau. ʻOi aku ka momona o ka waiwai ma kahi o 200 mau manawa ʻoi aku ka momona ma mua o ke kō. Ma hope o kahi kīʻaha e pili ana i kēia pūhui, ua hoʻopaʻa koke ʻia ʻo ia ma loko o nā ʻāpana liʻiliʻi. ʻAbollelo ʻia hoʻōla i loko o ke akeʻala ma o nā hopena transamination. ^ E Ha yM. I ka hopena, ua kūkulu ʻia nā 2 amino acid a me ka methanol. Hoʻopili ʻia nā huahana Metabolism ma o ka urinary system.

Nā hopena hopena

ʻO Aspartame kahi hana palekana palekana e mālama ʻole i ke kūkulu ʻia ʻana o kekahi ʻano hopena maikaʻi ʻole.

ʻIke pinepine paha ia:

• nā kuʻuna, me ke komo
• he nui e ulu ana i ka momona,
• nāʻuʻuku ʻili, nā ʻano hopena ʻē aʻe.

Mākaukau e loaʻa ana (Analogs)

Palapala ʻia ia mea i loko o nā inoa kālepa i hala iho nei: Sugafri, AminoSweet, Spoonful, NutraSweet, Canderel.

Hōʻike ʻia nā hōʻike o ka aspart insulin lāʻau, e like me ka pauku ʻana i ke olakino, i kapa ʻia "synonyms" - nā mea hoʻololi i hiki ke hoʻololi ʻia i hoʻokahi o nā mea kaha a ko lākou mau hopena ma ke kino. Ke koho ʻana i nā unuhi, e noʻonoʻo wale ʻaʻole i kā lākou kumukūʻai, akā no ke aupuni o ka hana a me ka maikaʻi hoʻi o ka mea hana.

Nā hopena hōʻike ʻike malihini

Hoike Hoike Makahiki

Hoʻomaopopo ʻo ka poʻe malihini

ʻO ka loiloi ʻana o ka poʻe malihini kipa

Hoʻokahi kekahi kipa i kahi helu intake i kēlā me kēia lā

Ehia mau e lawe ai i ka Insulin aspart biphasic * (Insulin aspart biphasic *)?
ʻO ka hapanui o nā mea pane i lawe i kēia lāʻau lapaʻau i nā manawa 2 i ka lā. Hōʻike ka hōʻike i ka pinepine o nā mea pane e lawe i kēia lāʻau lapaʻau.

Nā lālā	%
2 mau lā i kahi lā	1	100.0%

Ua kipa kekahi kipa i kahi manamana

Nā lālā	%
51-100mg	1

ʻO ka kaomi neʻe o ka glucose ma ke ʻano 1 a me ke ʻano type type 2 he hōʻoiaʻiʻo ʻana e hoʻohemo i ka hoʻomaka ʻana o nā hopena vascular. ʻO ka maʻi Insulin ka mea nui o ka maʻi maʻi no ka maʻi type 1 a me kekahi mau kūlana ke koi ʻia no nā maʻi maʻi type 2 e hui pū me nā lāʻau hypoglycemic. ʻO ka hoʻohanaʻana i nā lāʻau biphasic e hāʻawi i nā hopena maikaʻi.

ʻO ka wehewehe ʻana i ka lāʻau lapaʻau

ʻO ka hoʻohana ʻana i nā alapine basal o ka hormone kanaka, ʻaʻole ia e ʻae iā ʻoe e hoʻomalu i ka glycemia o nā maʻi, ʻoi aku hoʻi i ka pō. Ke hele nei ka maʻi, e koi mau ʻia ka hoʻoponopono ʻana o ka nui o ka insulin basal, a he mea nō hoʻi e hōʻeha i kekahi mau pilikia a ʻaʻole ʻae ʻoe i ka kaohi i ka hoʻonui ma glucose ma hope o ka ʻai ʻana. Nā hewa hewa kūpono e alakaʻi ai i ka holomua o ka maʻi.

I kēia mau makahiki i hala iho nei, ua hoʻomāhuahua nā mea āpau biphasic i loaʻa kahi pōmaikaʻi pōkole a lōʻihi, e like me ke Aspart lua-phase phase. ʻO ka hoʻohanaʻana i kahi hui base-bolus hiki ke maʻalahi i ka mālamaʻana i ka maʻi maʻi, no ka mea e hōʻemi ana i ka nui o nā inikini i kēlā me kēia lā.

ʻIkepili lāʻau lapaʻau

ʻO ka hoʻonohonoho o ka insulin Degludek / insulin Aspart e komo me ka 70% o kahi kinona o ka hana superlong (Degludec) a me 30% o ka puʻupuʻu insulin Aspart, kahi i hui pū ʻia i hoʻokahi maʻi. Ma hope o ka hoʻoponopono subcutaneous, hoʻokumu ʻia ka depot hormone, aia nā hexamers o ka mea ikaika.Noho mālie, ma ke ʻano o ka lā, ua hoʻohiolo ka nui o nā molekila Aspart i nā monomers, nā mea i hoʻoulu ʻia i ka wai koko a loaʻa kahi hopena like me ka hormone endogenous.

ʻO Bypasic insulin Aspart e hiki iā ʻoe ke hoʻomalu i ka pae o ka glycemia maikaʻi, ʻoi aku ka nui o ka hypoglycemia ma mua o ke hoʻohana wale ʻana i ka insulin basal a i ʻole mua aʻe o nā biphasic mua.

ʻOi aku ka mea nui ke kaohi o ka glucose i ka pō, no ka mea ke hoʻohana ʻana i ka mākaukau makin konane, hiki mai ka hoʻemi ʻana i ke kōpaʻa koko. A ke kaumaha nei kēia i ka pono o ka poʻe maʻi, hoʻonui i ka ʻeha o ka make koke.

Nā hōʻailona a me nā contraindications

Hoʻohana ʻia ka Bypasic insulin Aspart (kahi mea kikoʻī o Flexpen) i ka mālama ʻana i ka ʻano type type 1 a me ke ʻano type type 2 mellitus inā ua hala ia i ka insulin-depend phase.

ʻAʻole hoʻohana ʻia ka lāʻau me ka intolerance pilikino i kāna mau ʻāpana a me ka hoʻonui ʻana iā lākou. ʻAʻole i noiʻi ʻia ka noi ʻana i nā keiki i lalo o ke 6 mau makahiki o laila, no laila, ʻaʻole pono ke noi ʻia e hoʻohana i kekahi o ko lākou mau ʻelele i kēia makahiki.

No nā keiki i lalo o 6 mau makahiki o ka makahiki, ʻaʻole i ʻōlelo ʻia ka hoʻohana ʻana o Insulin aspart, a me nā wahine hāpai

Hoʻohana ʻia ka hoʻohana ʻana i ka hāpai ʻana. ʻAʻole i hoʻokō ʻia nā hoʻokolohua piha. Pili ka like me ka FlexPen a me Novorapid Penfill. Akā i loko o nā haʻawina ʻelua o ka lāʻau Novorapid Penfill ma nā wahine hāpai, ʻaʻohe data i loaʻa i ka hopena maikaʻi ʻole o ka waiwai ma ka hāpai ʻana a me ke ʻano o ka pēpē.

Hiki i nā makuahine kahu maʻi ke hoʻohana i ka insulin i ka nui o ka pono, ʻaʻole ia e pili i ke keiki. Pono paha e hoʻoponopono i ka ʻōpū no ka makuahine.

Hōʻike ka hoʻonāukiuki i ke ʻano o ka hana nui a ka hormone. ʻO ke kūlana o ka hypoglycemia i ka wā e hoʻohana ai i ka lāʻau biphasic e ulu pinepine i ka hanana pinepine ma mua o ka regimen dosage maʻamau.

Hōʻike ʻia kēia ʻanoʻano ʻino ʻekena:

• Urticaria, rashes ʻili, līkuhi - hoʻoiho kūloko.
• ʻO ka neuropathy peripheral.
• ʻO nā maʻi hōʻemi (ʻoi aku ka hoʻomaka i ka hopena), retinopathy.
• Lipodystrophy ma ka wahi ʻōlelo.
• Nā kūloko o ke kūloko ma nā wahi o ka ʻoihana.

Ke lawe nei i kekahi mau lāʻau lapaʻau me ka piʻi ʻana o ka hopena Aspart a me ka hiki ke hoʻomohala ʻana i ka hypoglycemia:

• Nā maʻi hoʻohālikelike.
• Nā mea hoʻonani o MAO, ACE.
• Hoʻopau.
• Nā diuretaha Thiazide.
• Heparin.

Hiki i ka alakino ke hoʻoikaika a hoʻonāwaliwali i ka hopena o ka mālama ʻana i ka hormonal.

Nā noi noi

Hoʻolālā wale ʻia ka Novorapid Penfill e like me ka subcutaneously, e like me nā lāʻau lapaʻau e loaʻa ai kahi inoa kālepa ʻē aʻe, akā like i ka mana. ʻAʻole hoʻohana ʻo Aspart i ka pohō i ka hoʻohana ʻana no ka hoʻopuʻe ʻana i nā pū o ka insulin. Koho ʻia ka maʻi ma kēlā me kēia hihia i kēlā me kēia.

ʻO ka regimen maʻamau no ke ʻano maʻi type 2 he hoʻokahi ʻauahi ma ke kakahiaka ma mua o ka ʻaina kakahiaka a i ʻole ma hope o a i kaha ʻia ka 6 huina ma mua o ka ʻaina.

Ke hoʻoneʻe ʻia mai nā ʻano lāʻau ʻē aʻe, e mālama pono ana ka mālama ʻana i ke kiʻekiʻe o ka glucose koko.

Nā hōʻike a me nā kumukūʻai

Loaʻa ka lāʻau lapaʻau Novomix Flekspen i ke ʻano o ka peni syringe me kahi mea i hoʻomākaukau ʻia no ka pākahi hoʻokahi. Aia nā 5 syringes i ka pākaukau. ʻO ke kumukūʻai mai 1559 rubles. Aia nā inoa Novomiks Flekspen i kahi hōʻailona helu like ʻole: 30, 50, 70. Ua like lākou me ka helu o nā Asparts i nā huaʻōlelo.

ʻO ke kumukūʻai o Novorapid Penfill ma waena o 1670 a 1900 mau rubles no ka pāleke.

Hoʻohālikelike

ʻO ke kūleʻa o ka maʻi maʻi kūleʻa wale nō me ka hoʻoponopono kūpono a me kaimenea dosage. Pono e hana ʻia e ke kauka, e pili ana i ka ikepili o ke ana ʻana i ka nui o ke kō i loko o kekahi mau lā. ʻO ka hoʻoponopono kūpono e hōʻemi i nā pilikia o ka hoʻomohalaʻana i nā hōʻeha o ka maʻi a ʻaʻole i hoʻopilikia i ka maikaʻi holoʻokoʻa.

Aia ke olakino a me ke ola o kahi maʻi maʻi i ka koho ʻana o ka insulin kiʻekiʻe kiʻekiʻe. ʻO ka papa lāʻau Insulin he lāʻau lapaʻau kaulana a kūpono hoʻi i hōʻike ʻia e nā kauka.Hoʻohana ʻia ia ma ke ʻano kūlohelohe no kou pono ponoʻī, e lilo ʻole i loko o ke kino a no laila e koi ʻia i ka hoʻomaka ʻana mai waho. Kōkua kēia i ka hoʻomaikaʻi ʻana i ke kūlana o ka mea maʻi a uku i ka maʻi mellitus, me ka hoʻēmi ʻana a me ka helu o ka ulu ʻana o nā ʻōhua kikoʻī.

ʻO ka huahana ikaika ka inoa like (insulin aspart). ʻO kēia ke ʻano o ka loli maʻamau o ke ʻano o ka hana ultrashort. Loaʻa iā ia ma muli o ka hōʻike ʻana i kahi mākēha kūikawā e hoʻohana ana i ka ʻenehana DNA recombinant. I ka hopena, ua hoʻololi ʻia ka prine acid amino i ka acid aspartic.

Kūpono ʻia e like me ka hoʻokuʻu ʻana, mākaukau no ka hoʻokele subcutaneous. Ke keʻokeʻo nei ka pakanā ma ke kala; ma ka hoʻonā ʻia, he ʻano keokeo keʻokeʻo ma lalo a me kahi wai hoʻokaʻawale ma luna o ka pahu. Me ka hoʻohaʻahaʻa ʻana a lulu paha, lilo ka wai i ka homogeneous hou.

Hiki ke ʻano ke kumukūʻai o ka lāʻau lapaʻau ma muli o ka nui o ka lāʻau. I ka awelika, 5 mau kukama o 3 ml kēlā me kēia kumukūʻai e pili ana i ka 1800 - 1900 mau rubles i loko o nā lāʻau lapaʻau ma Moscow.

Nā hōʻailona a me nā contraindications

Hōʻike ʻia ka Insart aspart no ka mellitus diabetes i hilinaʻi ʻia. ʻO ka maʻamau, kēia ia kahi maʻi o ka ʻano mua a me ke ʻano lua i kēlā mau kūlana i ka wā i hoʻohuli ai ia i kahi ʻano hana i hana ʻia i ka insulin. Ma ke ʻano ʻo ka maʻi āpau 2, ua kuhikuhi ʻia i ka wā e pau ai ka hoʻōla ʻana o ka lāʻau i lawe ʻia ma ke ʻano a i ʻole kekahi hapa nalo.

ʻAʻole kuhikuhi ʻia ka lāʻau lapaʻau no hypersensitivity i kāna hana koʻikoʻi nui (insin insulin) a me nā mea kōkua i ka mea haku. Pēlā pū kekahi contraindication e hoʻohana he mau a i ʻole wā maʻamau ka hypoglycemia. Eia nō hoʻi, ʻaʻole pono e kuhikuhi ʻia nā keiki ma lalo o 6 mau makahiki mai ka wā i mālama ʻia ʻole ai nā hoʻokolohua lapaʻau i kēia ʻano makahiki.

Ke hoʻomau nei ka noi ma ke wā hāpai ʻana, ʻoiai ʻaʻole i lawe ʻia nā haʻawina piha. I ka hoʻolālā ʻana a i ka wā hāpai paha, pono ia e hoʻomaopopo i ka endocrinologist e pili ana i kēia. I kekahi mau hihia, pono ʻoe e hoʻololi i ka lāʻau lapaʻau a kāpae paha i ka hoʻopau ʻana.

Ke noi

E hana ʻia nā ʻikepili hana kūʻokoʻa wale nō (ma ka waiho ʻole ʻana o nā ʻōlelo kikoʻī mai ke kauka hele mai. Hiki iā ʻoe ke hoʻokomo i ka hāmeʻa ma kekahi o kēia mau wahi:

1. ʻO ka pa
2. ʻEha
3. Buttock
4. I kekahi mau manawa, i ka poʻohiwi.

Hiki iā ʻoe ke hoʻohana i ka hana i ke kali ʻana ma mua a ma hope o ka ʻaina. Pono e mālama ʻia kahi manawa i kēlā me kēia wahi i kahi hou (i loko o ka pā o ka māhele o ke kino - poʻohiwi, ʻōpū, ʻōpū).

Ka helu ʻia o ka lāʻau lapaʻau no ka hoʻokele hoʻokahi i helu ʻia e ke kauka. Ka pono no ka insulin i kēlā me kēia mea maʻi ke kū hoʻokahi a hilinaʻi i nā mea he nui - ke kaupaona, ka makahiki, ke kūlana o ke olakino.

ʻO ka maʻamau, kahi e pili ana i ka 0.3 a i ka 1 IU i kēlā me kēia lā, akā hiki ke loli i ka wā o ka hapai, ka wā ʻōpiopio, ka maʻi menopause, a me nā hoʻololi hou e pili ana i ka hormonal.

Hoʻolā ʻia ka hoʻokele Intravenous ma muli o ka hopena nui o ka hypoglycemia. Akā i nā hihia kūikawā, hiki ke hoʻokō ʻia ma lalo o ka mālama ʻana o nā limahana olakino.

Ke loaʻa nei ka lāʻau lapaʻau - nā kāpae i ka like pū me kahi mea hoʻohui like a me ka hana ma ke kumu o ka hana like. ʻO ka hopena like lākou i ke kino. Eia nō naʻe, ʻe aku paha lākou i kahi inoa kālepa ʻē aʻe. ʻO kahi hoʻohālikelike o ka aspart insulin drug o ka NovoRapid Penfill a me kāna ʻano, NovoRapid FlexPenn, Novolog.

Aspartame - he aha ia?

ʻO kēia waiwai he mea hoʻohālike i ke kō, momona loa. Ua hana mua ʻia ka huahana ma ke ʻano he 60 o nā kenekulia 20. Loaʻa ia e chemist J.M. Schlatter, kahi mea ma kahi o nā hua o ka hopena e loaʻa , ua loaʻa ka mea ʻai i nā pono hana.

ʻO ka hoʻohuiʻana ma kahi o 200 mau manawa i ʻoi aku ka momona ma mua o ke kō. ʻOiai ka manaʻo o ka mea manamana he mau calorie kikoʻī (e pili ana iā 4 kilocalories no ka grala), e hana ai i kahi momona ʻono o ka waiwai, pono ʻoe e hoʻohui i ka mea ʻoi ka makemake o ka meli.No laila, i ka wā i hoʻohana ai i ka kuke ʻana, ʻaʻole lawe ʻia kāna waiwai caloric. Kūlike ʻia i huehue, ua nui ka hua ʻōlelo hou, ʻoi aku ka moʻo ʻana o ka pīhoihoi.

He aha ko Aspartame, kona mau wahi kino, ka hōʻeha o ka Aspartame

Loaʻa ka waiwai tīnaehana hoʻohuihui methylatedka mea e noho ai ke koena phenylalaninea aloha acid. ^ E Ha yM. Wahi a Wikipedia, ʻo kona molika molipoleka = 294, 3 mau pākēkē o nā mole, ʻo ka uku o ka huahana he 1,35 mau grika pākēnika pākēneka. Ma muli o ke kumu o ka huehue o ka waiwai mai 246 a 247 degere Celsius, ʻaʻole hiki ke hoʻohana ʻia i nā mea momona i hiki ke kau ʻia i ka mālama wela. ʻO ka hoʻohuiʻana i ka solubility maʻalahi i ka wai a me nā mea'ē aʻe. ʻaʻopiʻi paʻā.

Harm of Aspartame

I kēia manawa, hoʻohana ikaika ʻia ka hāmeʻa e like me ka hoʻoweliweli ʻana i nā mea - Aspartame E951.

Ua ʻike ʻia ma hope o ka komo ʻana i ke kino o ke kanaka, pio ke ʻano o loko a me métanolol. ^ E Ha yM. ʻO ka Methanol i nā nui he nui nā mea make. Akā, ʻo ka nui o ka methanol i loaʻa i kahi kanaka i ka wā eʻai ai ka nui ma mua o ka kiʻekiʻe o ka waihona i hoʻoiho ʻia mai ka hemo ʻana o Aspartame.

Ua hōʻoia ʻia he nui ka nui o ka methanol i loko o ke kino o ke kanaka. Ma hope o ka ʻai ʻana i hoʻokahi kīʻaha o ka hua wai huaʻai, he ʻano nui aʻe o kēia pūlea ma mua o ka pau ʻana o ka nui o nā wai inu i ʻāpono ʻia me Aspartame.

Ua hoʻokolohua ʻia nā haʻawina hoʻokolohua a me nā maʻi toxicological i hōʻoia e hōʻoiaʻiʻo ʻole ka mea ʻoluʻolu. I kēia hihia, ua hoʻomau ʻia ka loaʻa ʻana o nā lā i kēlā me kēia lā i ka lāʻau. He 40-50 mg pākaha i ke kaupaona o ke kino i kēlā me kēia lā, ʻo ia ka mea e like me nā papa he 266 o kahi mea hoʻoliʻelima synthetic no kahi kanaka e kaupaona ana i 70 kg.

I ka makahiki 2015, ʻelua hoʻokolokolo hoʻokūkū paʻa kope, i hui ʻia e nā kānaka he 96. I ka hopena, ʻaʻole i loaʻa nā hōʻailona metabola a me nā kumumanaʻo o kahi uaki maikaʻi ʻole i ka mea moʻomeheu maoli.

Ka hana lāʻau lapaʻau

Pharmacodynamics a me ka pharmacokinetics

ʻO Aspartame, he aha ia, pehea ka ulu ʻana o kona metabolism?

Loaʻa ka mea hana i nā protein nui o nā meaʻai maʻamau. ʻOi aku ka momona o ka waiwai ma kahi o 200 mau manawa ʻoi aku ka momona ma mua o ke kō. Ma hope o kahi kīʻaha e pili ana i kēia pūhui, ua hoʻopaʻa koke ʻia ʻo ia ma loko o nā ʻāpana liʻiliʻi. ʻAbollelo ʻia hoʻōla i loko o ke akeʻala ma o nā hopena transamination. ^ E Ha yM. I ka hopena, ua kūkulu ʻia nā 2 amino acid a me ka methanol. Hoʻopili ʻia nā huahana Metabolism ma o ka urinary system.

Nā hōʻailona no ka hoʻohana ʻana

Hoʻohana ʻia ʻo Aspartame e hōʻemi i ka waihona calorie o nā mea inu a me nā meaʻai. Me kēia hāmeʻa, hiki iā ʻoe ke kāohi i ka paona a me ke kō pae koko.

Nā Hoʻohui

• inā he mea ʻono,
• me ka maʻi ʻokoʻa.

Pono e mālama ʻia e nā wahine hāpai a me nā keiki.

Nā hopena hopena

ʻO Aspartame kahi hana palekana palekana e mālama ʻole i ke kūkulu ʻia ʻana o kekahi ʻano hopena maikaʻi ʻole.

ʻIke pinepine paha ia:

• nā kuʻuna, me ke komo
• he nui e ulu ana i ka momona,
• nāʻuʻuku ʻili, nā ʻano hopena ʻē aʻe.

ʻO Aspartame, nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana (Ke ʻano a me ke ʻano)

Lawe ʻia ka waiwai ma ke ʻano. ʻO ke ʻano o ka hoʻoponopono ʻana i ka meaʻai a ka lāʻau lapaʻau.

Aspartame, kuhikuhi no ka hoʻohana ʻana

ʻO ka nui o ka momona he hiki ke hoʻopau ʻia i kēlā me kēia lā, me ka ʻole o ka hōʻeha i ke kino he 40-50 mg pākēneka i ke kaupaona o ke kino.

Ke keu

ʻAʻohe ʻikepili ma ka overdose o ka lāʻau lapaʻau. Ua manaʻoʻiʻo ia ka hoʻohana ʻana o kēlā me kēia lā i nā nui nui o kekahi mea hiki i ke kūkulu ʻana i neoplasms malignanta i ʻole ka lolo.

Hoʻohui

ʻAʻole pū ka mea kanu me nā lāʻau like ʻole.

Kūlana o ke kūʻai aku

ʻAʻohe kumu ʻike.

Nā kūlana mālama

Nā ʻōlelo kikoʻī

I ka wā lōʻihi o ka mālama ʻana, hoʻopau ka mea i nalo a haʻalele i kāna ono momona.

No ka hoʻoluhi kaumaha

E951 pinepine i loko o nā mea inu meaʻai. Me kēia paena hiki iā ʻoe ke kāohi i ka paona.

I ka wā hāpai a me ka lactation

Mākaukau e loaʻa ana (Analogs)

Palapala ʻia ia mea i loko o nā inoa kālepa i hala iho nei: Sugafri, AminoSweet, Spoonful, NutraSweet, Canderel.

Hōʻike ʻia nā hōʻike o ka aspart insulin lāʻau, e like me ka pauku ʻana i ke olakino, i kapa ʻia "synonyms" - nā mea hoʻololi i hiki ke hoʻololi ʻia i hoʻokahi o nā mea kaha a ko lākou mau hopena ma ke kino. Ke koho ʻana i nā unuhi, e noʻonoʻo wale ʻaʻole i kā lākou kumukūʻai, akā no ke aupuni o ka hana a me ka maikaʻi hoʻi o ka mea hana.

ʻO ka wehewehe ʻana i ka lāʻau lapaʻau

Hoʻopili pū kekahi me kahi receptor kūikawā ma ka membone cytoplasmic o waho o nā pūpū a hana i kahi mea hoʻohui insulin-receptor e hoʻoikaika i nā hanana intracellular, e komo synthesis o kekahi o nā kīʻaha koʻikoʻi (hexokinase, pyruvate kinase, glycogen synthetase). Hoʻohui ka hopena hypoglycemic me ka nui o ka holo intracellular a me ka hoʻonui ʻana i ka hoʻoliʻi o ka glucose ma o nā kiko, hoʻoulu ʻana i ka lipogenesis, glycogenogenesis, a me kahi ka emi o ka hōʻaia o ka hana glucose e ka ʻāʻī.

ʻO ka ʻaina Insulin a me ka insulin kanaka like like i ka hana like me ka molar like.

Hoʻokomo ka aspart Insulin mai ka momona o ka subcutaneous me ka wikiwiki a ʻoi aku ka wikiwiki ma mua o ka insulin soluble kanaka.

ʻO ka lōʻihi o ka hana o ka insulin aspart ma hope o ka hoʻokele sc me ka liʻiliʻi ma mua o ka hoʻomehana ʻana i ka insulin kanaka.

Kahi papa inoa o nā kūmole

E makaʻala! Aia ka papa inoa i nā huaʻōlelo no ka Insulin aspart, kahi ʻano like, no laila hiki iā ʻoe ke koho i kahi neʻe iā ʻoe iho, me ka nānā ʻana i ke ʻano a me ka ʻano o ka lāʻau lapaʻau i kauoha ʻia e kāu kauka. E hāʻawi i ka makemake i nā mea hana mai ka USA, Japan, Western Europe, a me nā ʻoihana maikaʻi loa mai ʻEulopa Hui Pū ʻIa: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Nā hopena hōʻike ʻike malihini

Elima mau malihini kipa i hōʻike mai i nā helu intake i kēlā

Ehia mau e lawe ai i ka aspart insulin.
ʻO ka hapanui o nā mea pane i hana pinepine i kēia lāʻau lapaʻau i nā manawa 3 i ka lā. Hōʻike ka hōʻike i ka pinepine o nā mea pane e lawe i kēia lāʻau lapaʻau.

Nā lālā	%
3 mau lā i ka lā	2	40.0%
4 lā i ka lā	2	40.0%
2 mau lā i kahi lā	1	20.0%

Elima mau malihini kuhi i ka helu ana

Nā lālā	%
1-5mg	3	60.0%
11-50mg	1	20.0%
51-100mg	1	20.0%

Ua hōʻike aku kahi mea kipa i kahi lā pau

Pehea ka lōʻihi e lawe ai i ka aspart insulin e manaʻo ai i ka holomua o ke kūlana o ka mea maʻi?
ʻO ka poʻe ʻikepili o ka hōʻike hōʻike i nā hapa he nui ma hope o ka hebedoma i loaʻa i kahi holomua. Akā ʻaʻole paha e kūpono kēia i ka manawa āu e hoʻomaikaʻi ai. E nīnau aku i kāu kauka no ka lōʻihi o kou makemake e lawe i kēia lāʻau lapaʻau. Hōʻike ka papa ma lalo nei i nā hopena o ka noiʻi ma ka hoʻomaka ʻana o kahi hana kūpono.

Hoʻokipa kekahi kipa i kahi manawa lohi

ʻO ka manawa hea ʻoi aku ka maikaʻi o ka lawe ʻana i ka mea kuhi Insulin: ma kahi ʻōpū ʻole, ma mua, ma hope a i ʻole me ka meaʻai?
Hoʻomaopopo pinepine nā mea hoʻohana o ka pūnaewele e lawe nei i kēia lāʻau lapaʻau ma hope o ka papaʻaina. Eia naʻe, hiki i ke kauka ke ʻōlelo aku i kahi manawa ʻē aʻe. Hōʻike ka hōʻike ʻana i ka wā i lawe ai ke koena o nā mea maʻi i ka lāʻau lapaʻau.

ʻO ka inoa kalepa a me ke puka i hoʻokuʻu ʻia

Kūkulu ʻia ʻo Aspart ma ke ʻano aniani a he ʻāpana o ka mākaukau paʻakikī. Aia a he nui nā ʻano hoʻohālikelike i ke ʻano nui o ka pakanui mea maʻamau. Pili ka inoa kālepa ma ke ʻano helu a me ke ʻano o ka lāʻau lapaʻau.

ʻAno	Kauka-kalepa	E hoʻokuʻu i ke ʻano
Hoʻokahi ʻano	NovoRapid® Penfill®	Hoʻololi i nā pahu pahu
	NovoRapid® Flexpen®	Peni Syringe
ʻO nā Biphasic	NovoMix® 30 Penfill®	Hoʻololi i nā pahu pahu
	NovoMix® 30 FlexPen®	Peni Syringe
	Ryzodeg® Penfill®	Hoʻololi i nā pahu pahu
	Risedeg® FlexTouch®	Peni Syringe

Na ke kālepa mea kālepa e hoʻokele ʻia e ka hui ʻo Danish ʻo Novo Nordisk.

Nā ʻōkuhi no ka hoʻohana

ʻO ke ʻano o ka hoʻohana ʻana a me ke ʻano o ka lāʻau lapaʻau ka mea e kau ai i ka ʻano dosage, ʻano o ka maʻi, ke ʻano o nā pathology concomitant a me nā makahiki o ka mea maʻi.

• Ua hoʻokomo ʻia nā ʻōkuhi i ka subcutaneously (i ka papakai momona), no ka mea, hemo liʻiliʻi ka insulin i ka waiwai a hoʻopuka koke ʻia mai ke kino, me ka intramuscular injection.
• Pono e hoʻololi pinepine ʻia nā pūnaewele injection, no ka mea, hiki i ka momona ke hana i ka momona momona.
• ʻO nā lehelehe lipodystrophic,
• ʻAʻole pono e ʻae ʻia nā pono e hoʻohana pono i ka pale ʻana.

Pehea e hoʻohana ai i ka aspart insulin? Nānā i nā ʻōkuhi no ka hoʻohana ʻana i nā ʻōlelo like ʻole no ka lāʻau pākahi hoʻokahi a me ʻelua.

ʻO ka hoʻohana ʻana o ka aspart maʻamau

ʻO kahi luna o kēia ʻano lāʻau lapaʻau hypoglycemicʻo NovoRapid. He lāʻau wikiwiki ma ka wikiwiki me ka hana pōkole. Hōʻike ka hopena glycemic ma hope o 10-20 mau minuke, ma hope o ka hoʻonāukiuki a subcutaneous a infusion paha. Hoʻomaopopo ka hopena kiʻekiʻe ma hope o nā minuke 40 a emi iki ka lōʻihi, hiki i ka liʻiliʻi ma hope o 5 mau hola.

Ke mālama nei i ka glycemia maʻamau, me ka ʻole o nā manawa e hoʻonui a hoʻemi paha i ke kō (ma waho o ke ʻano maʻamau) e mālama pono ʻia nā pae glucose o ke koko.

Hoʻ lawe ʻia ʻia ma ka hoʻohana ʻana i kēia ʻano:

Pono e lawe ʻia nā ana ma mua a ma hope o ka ʻai. No ka helu pololei ʻana i kahi pākahi hoʻokahi o ka lāʻau lapaʻau, hiki ke hoʻāla ka nui o ke kōpaʻa ma mua o ka ʻai ʻana, a hoʻohana ʻia nā waiwai postprandial e hoʻoponopono i nā hōʻailona.

Hoʻohana ʻia ka NovoRapid e hoʻohana ana i ka ʻona ʻĀina i ka ʻĀina UV 100, kahi peni peni a i ʻole kahi pami. Ke ʻae ʻia nei ka hoʻokele intravenous e nā limahana lapaʻau ʻoihana kūpono loa, i nā kūlana o ka mālama ʻana. ʻO ka nui o nā ʻāpana no ka hōʻemi ʻana i ka lāʻau lapaʻau e hoʻoholo ʻia e ke kauka e hele ana.

Hoʻopili helu ʻia kēlā me kēia lā, ma muli o ka maʻi o ka mea maʻi a me ke kaumaha o ke kino. Aia ka pono o kēlā me kēia lā i kahi ma waena o 0.5-1 ED / kg o ke kaumaha o ke kino. ʻAʻole hiki iā ʻoe ke komo i ka paukū o ka lā maʻamau o ka aspart koke, no ka mea e alakaʻi kēia i ka hypoglycemia a me ka coma. Hoʻololi ʻia kahi ʻano hoʻokahi no kēlā me kēia ʻaina o ka meaʻai karoli.

KAUKA MAUI! Ke lawe nei ka helu ʻana i kahi pākahi hoʻokahi no NovoRapid i ka mālama ʻana i nā pūʻulu ʻai (XE) i hoʻopau ʻia i ka wā e ʻai ai.

Kūpono ka mea pono i ka insulin hana pōkole e pili ana i ka hana hormonal a me ka hana kino, ma ka lā o ke ao. I nā kakahiaka kakahiaka, hoʻonui paha ka pono, a ma hope o ka hoʻoikaika kino kino a i ke ahiahi paha - e emi ana.

ʻO ka hoʻohana nui ʻana o ka puaʻa biphasic

Hoʻohana ʻia ʻo NovoMix (ʻelena o ka biphasic aspart) no nā mea maʻi me ka maʻi type 2. ʻO ka ʻōmole i ʻōlelo ʻia, i ka hoʻomaka ʻana o ka pena ʻana, he 12 mau ʻāpana, i mālama ʻia i ke ahiahi, ma mua o ka papaʻaina. No ka hoʻokō ʻana i kahi hopena i hoʻopaʻa ʻia, i manaʻo ʻia e hoʻokaʻawale i kahi hoʻokahi i ʻelua mau pona. Me kēia hoʻolaha, ua kau lākou i nā mea 6 o NovoMix ma mua o ka pāʻina kakahiaka a i ke ahiahi, ma mua o ka papaʻaina.

Maʻikaʻi wale nō ka ʻaha subcutaneous o ka biphasic aspart e ʻae ʻia. E kāohi i nā kiʻekiʻe o ke kō a me ka hoʻoponopono ʻana i ka waiʻaila, pono e ana i ke ana o ka pae koko. Hoʻoponopono ʻia ka hoʻoponopono ʻia o ka hana ma hope o ka kahakiʻi ʻana i kahi papa hoʻonohonoho, e noʻonoʻo ana i ka wikiwiki o ke kō (ma ke kakahiaka, ma kahi ʻōpū ʻole), no 3 mau lā.

ʻO nā kumuʻai a me nā analog

Ke kumukūʻai o ka lāʻau lapaʻau e hilinaʻi ʻia i ke ʻano ma ka hopena o ka insulin aspart. Hōʻike ʻia ke kumukūʻai o nā lāʻau lapaʻau a me nā mea hoʻomehana.

Ke poʻo inoa	E hoʻokuʻu i ke ʻano	ʻO ke kumu kūʻai, rub.
NovoRapid® Penfill®	3 ml / 5 pcs	1950
NovoRapid® Flexpen®		1700
NovoMix® 30 FlexPen®		1800
Apidra SoloStar		2100
Biosulin		1100

ʻO ka likeʻana o nā aspart ka hopena like like, akā hana ʻia ma ke kumu o nā mea ikaika e ae. Kuhi ʻia nā lāʻau lapaʻau no ka hoʻohana lāʻau ʻana.

ʻO ka Insulin aspart kahi mea hana hypoglycemic maikaʻi. ʻAʻole loaʻa kahi helu nui o nā contraindications a ua hoʻohana ʻia ma ka māhele o ka hopena paʻakikī i ka maʻi mellitus o nā maʻi mellitus, nā ʻano ʻelua. He kūpono ia ia lāʻau lapaʻau no nā keiki a me nā pākeke, ʻo ia hoʻi no ka poʻe pākeke.

ʻElua hopena:

ʻO nā maʻi ʻino e nānā ʻia ana i nā maʻi e hoʻohana nei iā NovoRapid® Penfill® ma muli o ka hopena pharmacological o ka insulin.
ʻO ka hopena maʻamau e hōʻike ai no ka hypoglycemia. Ka loli ʻana o ka hopena o ka hopena e pili ana i ka heluna o ka mea maʻi, ka hoʻoponopono o ka doses, a me ka kontrol glycemic (e ʻike i ka ʻāpana ma lalo).
I ka hoʻomaka mua o ka inika insulin, nā hewa reactive, edema a me nā hopena e hiki mai ana ma ka pūnaewele injection (pain, redness, hives, inflammation, hematoma, ka ʻōpū a me ka ʻeha i ka pūnaewele injection). Hoʻopili iki kēia mau ʻōuli i ke ʻano. Hiki i ka hoʻomaikaʻi wikiwiki ʻana i ka mālama glycemic ke alakaʻi i kahi kūlana o ka "neuropathy eha ʻeha," i ʻeli pinepine ʻia e ia. Ka hoʻonāukiuki ʻana o ka inikini insulin me ka hoʻomaikaʻi koʻikoʻi i ka kaohi o ka mea laʻala kalaiwa hiki ke alakaʻi i kahi wā pōkole i ke kūlana o ka maʻi retinopathy maʻi, ʻoiai ka lōʻihi o ka hoʻomaikaʻi ʻana i ka glycemic control hōʻemi i ka hopena o ka holomua o ka maʻi retinopathy diabetes.
Hōʻike ʻia ka papa inoa o nā hana ʻino i ka papaʻaina.

Hoʻokomo ʻia kahi ʻōnaehana Pūnaewele	ʻOhiʻeha - Hives, rashes, ʻili pali
Kuhi hewa loa - Anaphylactic reaction *
ʻO ka huʻihuʻi me ka meaʻaiʻaiʻai	Loaʻa pinepine - Hypoglycemia *
ʻO nā maʻi o ka pūnao	Aele loa - peripheral neuropathy ("ʻoiʻi ka maʻi neuropathy ʻeha")
Kuee ʻia o nā io o ka ʻike	Kekahi - hanaʻole o ka hoʻopaʻi
ʻO ka pinepine - retinopathy diabetic
Nā maʻi hōʻeha o ka ʻili a me ke kiko	Kanaluhi - lulax *
ʻO nā maʻi maʻamau a me nā maʻi i ka pūnaewele injection	Hoko - nā luhi ma ka wahi i ʻōlelo ʻia
Loaʻa - edema

* E nana aku "Ka wehewehe ʻana i nā kūʻokoʻa pili hewa"
ʻO nā hopena ʻino loa i hōʻike ʻia ma lalo nei, e pili ana i ka ʻike hoʻokolohua hoʻonaʻauao, e ʻāʻawale ʻia e like me ke alualu ʻana i ka hanana e like me MedDRA a me nā ʻōnaehana organ. ʻO ka hoʻāliʻi o nā hopena ʻino e wehewehe ʻia ma: pinepine pinepine (≥ 1/10), pinepine pinepine (≥ 1/100 a. Hana hana Pharmacological - hypoglycemic.

Hoʻopili ʻo ia me nā mea nānā aku o ka membone cytoplasmic o nā pā a hoʻāla i ka pūhui insulin-receptor e hoʻoikaika i nā hanana intracellular, e komo pū ana synthesis o kekahi o nā kīʻaha koʻikoʻi (hexokinase, pyruvate kinase, glycogen synthetase). ʻO ka emi ʻana o ke kao o ka glucose i ka koko ma muli o ka hoʻonui ʻana i kāna kaʻi intracellular, hoʻonui i ka hoʻowalewale ʻana e nā ʻūluna a me nā kiko adipose, a me ka emi ʻana o ka hōʻemi o ka hana glucose i loko o ka ate. ʻO ia ka hana like me ke insulin kanaka i nā molar kūlike. ʻO ka hoʻoneʻe ʻana o ka hinu waikawa amino ma ke kūlana B28 me ka waikawa aspartic e hōʻemi ana i ka ulu ʻana o nā molekala e hoʻokumu i ka hexamers i ka hapa wai o nā lāʻau lapaʻau, i ʻike ʻia i ka soluble insulin kanaka. I kēia hana, ua hoʻoneʻe ʻia ka aspart insulin mai ka momona subcutaneous ma mua o ka soluble insuline i loaʻa i ka insulin kanaka biphasic. Hoʻokomo hou ka Insulin aspart protamine. Ma hope o ka hoʻomalu sc, hoʻomohala ka hopena ma hope o 10-20 mau minuke, ka hopena loa - ma hope o nā hola 1-4, ka lōʻihi o ka hana - a hiki i ka 24 hola (e pili ana i ke ʻano, ka wahi o ka hoʻokele ʻana, ka ikaika o ke kahe, ke ʻano o ke kino a me ka pae o ka hana kino).

Ke hoʻo / i ka hoʻomaka ʻana o kahi huaʻai o 0.2 PIECES / kg o ke kino koʻikoʻi T max - 60 mau minuke Hoʻololi loa ka hoʻopaʻa ʻana i nā protein koko (0-9%).ʻO ka hoʻoneʻeʻana o ka insulin serum e hoʻi i ka mea hele ma hope o nā hola 15-18.

Hoʻohui

ʻAʻole pū ka mea kanu me nā lāʻau like ʻole.

Kūlana o ke kūʻai aku

ʻAʻohe kumu ʻike.

Nā kūlana mālama

Nā ʻōlelo kikoʻī

I ka wā lōʻihi o ka mālama ʻana, hoʻopau ka mea i nalo a haʻalele i kāna ono momona.

No ka hoʻoluhi kaumaha

E951 pinepine i loko o nā mea inu meaʻai. Me kēia paena hiki iā ʻoe ke kāohi i ka paona.

I ka wā hāpai a me ka lactation

Mākaukau e loaʻa ana (Analogs)

Palapala ʻia ia mea i loko o nā inoa kālepa i hala iho nei: Sugafri, AminoSweet, Spoonful, NutraSweet, Canderel.

Hōʻike ʻia nā hōʻike o ka aspart insulin lāʻau, e like me ka pauku ʻana i ke olakino, i kapa ʻia "synonyms" - nā mea hoʻololi i hiki ke hoʻololi ʻia i hoʻokahi o nā mea kaha a ko lākou mau hopena ma ke kino. Ke koho ʻana i nā unuhi, e noʻonoʻo wale ʻaʻole i kā lākou kumukūʻai, akā no ke aupuni o ka hana a me ka maikaʻi hoʻi o ka mea hana.

ʻO ka wehewehe ʻana i ka lāʻau lapaʻau

Hoʻopili pū kekahi me kahi receptor kūikawā ma ka membone cytoplasmic o waho o nā pūpū a hana i kahi mea hoʻohui insulin-receptor e hoʻoikaika i nā hanana intracellular, e komo synthesis o kekahi o nā kīʻaha koʻikoʻi (hexokinase, pyruvate kinase, glycogen synthetase). Hoʻohui ka hopena hypoglycemic me ka nui o ka holo intracellular a me ka hoʻonui ʻana i ka hoʻoliʻi o ka glucose ma o nā kiko, hoʻoulu ʻana i ka lipogenesis, glycogenogenesis, a me kahi ka emi o ka hōʻaia o ka hana glucose e ka ʻāʻī.

ʻO ka ʻaina Insulin a me ka insulin kanaka like like i ka hana like me ka molar like.

Hoʻokomo ka aspart Insulin mai ka momona o ka subcutaneous me ka wikiwiki a ʻoi aku ka wikiwiki ma mua o ka insulin soluble kanaka.

ʻO ka lōʻihi o ka hana o ka insulin aspart ma hope o ka hoʻokele sc me ka liʻiliʻi ma mua o ka hoʻomehana ʻana i ka insulin kanaka.

Kahi papa inoa o nā kūmole

E makaʻala! Aia ka papa inoa i nā huaʻōlelo no ka Insulin aspart, kahi ʻano like, no laila hiki iā ʻoe ke koho i kahi neʻe iā ʻoe iho, me ka nānā ʻana i ke ʻano a me ka ʻano o ka lāʻau lapaʻau i kauoha ʻia e kāu kauka. E hāʻawi i ka makemake i nā mea hana mai ka USA, Japan, Western Europe, a me nā ʻoihana maikaʻi loa mai ʻEulopa Hui Pū ʻIa: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Nā hopena hōʻike ʻike malihini

Ua hōʻike kekahi kipa i ka hana

Ua kipa kekahi kipa i kahi kumukūʻai kumukūʻai

Nā lālā	%
ʻĀina	1	100.0%

Elima mau malihini kipa i hōʻike mai i nā helu intake i kēlā

Ehia mau e lawe ai i ka aspart insulin.
ʻO ka hapanui o nā mea pane i hana pinepine i kēia lāʻau lapaʻau i nā manawa 3 i ka lā. Hōʻike ka hōʻike i ka pinepine o nā mea pane e lawe i kēia lāʻau lapaʻau.

Nā lālā	%
3 mau lā i ka lā	2	40.0%
4 lā i ka lā	2	40.0%
2 mau lā i kahi lā	1	20.0%

Elima mau malihini kuhi i ka helu ana

Nā lālā	%
1-5mg	3	60.0%
11-50mg	1	20.0%
51-100mg	1	20.0%

Ua hōʻike aku kahi mea kipa i kahi lā pau

Pehea ka lōʻihi e lawe ai i ka aspart insulin e manaʻo ai i ka holomua o ke kūlana o ka mea maʻi?
ʻO ka poʻe ʻikepili o ka hōʻike hōʻike i nā hapa he nui ma hope o ka hebedoma i loaʻa i kahi holomua. Akā ʻaʻole paha e kūpono kēia i ka manawa āu e hoʻomaikaʻi ai. E nīnau aku i kāu kauka no ka lōʻihi o kou makemake e lawe i kēia lāʻau lapaʻau. Hōʻike ka papa ma lalo nei i nā hopena o ka noiʻi ma ka hoʻomaka ʻana o kahi hana kūpono.

Hoʻokipa kekahi kipa i kahi manawa lohi

ʻO ka manawa hea ʻoi aku ka maikaʻi o ka lawe ʻana i ka mea kuhi Insulin: ma kahi ʻōpū ʻole, ma mua, ma hope a i ʻole me ka meaʻai?
Hoʻomaopopo pinepine nā mea hoʻohana o ka pūnaewele e lawe nei i kēia lāʻau lapaʻau ma hope o ka papaʻaina. Eia naʻe, hiki i ke kauka ke ʻōlelo aku i kahi manawa ʻē aʻe. Hōʻike ka hōʻike ʻana i ka wā i lawe ai ke koena o nā mea maʻi i ka lāʻau lapaʻau.

Ua hōʻike aku ʻekolu kipa i nā makahiki ahonui

Hōʻike nā kipa

ʻAʻohe ʻike ʻike

Nā ʻōlelo kuhikuhi i ka hoʻohana ʻana

NOVORAPID® PENFILL® (NOVORAPID® PENFILL®)

Ka helu helu helu:

Nā palapala ʻano:

Hoʻolaha hui:

Lapaʻa lāʻau:

Nā hōʻailona no ka hoʻohana ʻana:

Nā pālua:

Nā ʻoslelo a me ke hoʻoponopono:

ʻElua hopena:

ʻO nā maʻi ʻino e nānā ʻia ana i nā maʻi e hoʻohana nei iā NovoRapid® Penfill® ma muli o ka hopena pharmacological o ka insulin.
ʻO ka hopena maʻamau e hōʻike ai no ka hypoglycemia. Ka loli ʻana o ka hopena o ka hopena e pili ana i ka heluna o ka mea maʻi, ka hoʻoponopono o ka doses, a me ka kontrol glycemic (e ʻike i ka ʻāpana ma lalo).
I ka hoʻomaka mua o ka inika insulin, nā hewa reactive, edema a me nā hopena e hiki mai ana ma ka pūnaewele injection (pain, redness, hives, inflammation, hematoma, ka ʻōpū a me ka ʻeha i ka pūnaewele injection). Hoʻopili iki kēia mau ʻōuli i ke ʻano. Hiki i ka hoʻomaikaʻi wikiwiki ʻana i ka mālama glycemic ke alakaʻi i kahi kūlana o ka "neuropathy eha ʻeha," i ʻeli pinepine ʻia e ia. Ka hoʻonāukiuki ʻana o ka inikini insulin me ka hoʻomaikaʻi koʻikoʻi i ka kaohi o ka mea laʻala kalaiwa hiki ke alakaʻi i kahi wā pōkole i ke kūlana o ka maʻi retinopathy maʻi, ʻoiai ka lōʻihi o ka hoʻomaikaʻi ʻana i ka glycemic control hōʻemi i ka hopena o ka holomua o ka maʻi retinopathy diabetes.
Hōʻike ʻia ka papa inoa o nā hana ʻino i ka papaʻaina.

Hoʻokomo ʻia kahi ʻōnaehana Pūnaewele	ʻOhiʻeha - Hives, rashes, ʻili pali
Kuhi hewa loa - Anaphylactic reaction *
ʻO ka huʻihuʻi me ka meaʻaiʻaiʻai	Loaʻa pinepine - Hypoglycemia *
ʻO nā maʻi o ka pūnao	Aele loa - peripheral neuropathy ("ʻoiʻi ka maʻi neuropathy ʻeha")
Kuee ʻia o nā io o ka ʻike	Kekahi - hanaʻole o ka hoʻopaʻi
ʻO ka pinepine - retinopathy diabetic
Nā maʻi hōʻeha o ka ʻili a me ke kiko	Kanaluhi - lulax *
ʻO nā maʻi maʻamau a me nā maʻi i ka pūnaewele injection	Hoko - nā luhi ma ka wahi i ʻōlelo ʻia
Loaʻa - edema

* E nana aku "Ka wehewehe ʻana i nā kūʻokoʻa pili hewa"
ʻO nā hopena ʻino loa i hōʻike ʻia ma lalo nei, e pili ana i ka ʻike hoʻokolohua hoʻonaʻauao, e ʻāʻawale ʻia e like me ke alualu ʻana i ka hanana e like me MedDRA a me nā ʻōnaehana organ. ʻO ka hoʻāliʻi o nā hopena ʻino e wehewehe ʻia ma: pinepine pinepine (≥ 1/10), pinepine pinepine (≥ 1/100 a. Hana hana Pharmacological - hypoglycemic.

Hoʻopili ʻo ia me nā mea nānā aku o ka membone cytoplasmic o nā pā a hoʻāla i ka pūhui insulin-receptor e hoʻoikaika i nā hanana intracellular, e komo pū ana synthesis o kekahi o nā kīʻaha koʻikoʻi (hexokinase, pyruvate kinase, glycogen synthetase). ʻO ka emi ʻana o ke kao o ka glucose i ka koko ma muli o ka hoʻonui ʻana i kāna kaʻi intracellular, hoʻonui i ka hoʻowalewale ʻana e nā ʻūluna a me nā kiko adipose, a me ka emi ʻana o ka hōʻemi o ka hana glucose i loko o ka ate. ʻO ia ka hana like me ke insulin kanaka i nā molar kūlike. ʻO ka hoʻoneʻe ʻana o ka hinu waikawa amino ma ke kūlana B28 me ka waikawa aspartic e hōʻemi ana i ka ulu ʻana o nā molekala e hoʻokumu i ka hexamers i ka hapa wai o nā lāʻau lapaʻau, i ʻike ʻia i ka soluble insulin kanaka. I kēia hana, ua hoʻoneʻe ʻia ka aspart insulin mai ka momona subcutaneous ma mua o ka soluble insuline i loaʻa i ka insulin kanaka biphasic. Hoʻokomo hou ka Insulin aspart protamine. Ma hope o ka hoʻomalu sc, hoʻomohala ka hopena ma hope o 10-20 mau minuke, ka hopena loa - ma hope o nā hola 1-4, ka lōʻihi o ka hana - a hiki i ka 24 hola (e pili ana i ke ʻano, ka wahi o ka hoʻokele ʻana, ka ikaika o ke kahe, ke ʻano o ke kino a me ka pae o ka hana kino).

Ke hoʻo / i ka hoʻomaka ʻana o kahi huaʻai o 0.2 PIECES / kg o ke kino koʻikoʻi T max - 60 mau minuke Hoʻololi loa ka hoʻopaʻa ʻana i nā protein koko (0-9%). ʻO ka hoʻoneʻeʻana o ka insulin serum e hoʻi i ka mea hele ma hope o nā hola 15-18.

Ka hoʻohana ʻana o ka waiwai Insulin aspart biphasic

ʻO ka maʻi mellitus type type 1 (ka hihia i ka kūlohelohe i nā hopena hypoglycemic waha, ke kū'ē i ka pale ʻana i kēia mau lāʻau i ka wā e hui pū ai, me nā maʻi kūlohelohe).

Nā Hoʻohui

Wāwī palapala noi

ʻAe a i luna o 18 mau makahiki (ʻaʻole i hoʻoholo ʻia ka palekana a me ka pono).

ʻŌpū a me ka lactation

ʻAʻole i hoʻokō ʻia nā hana hoʻouluulu holoholona me ka hoʻohana ʻana i ka insulin aspart biphasic. Eia nō naʻe, nā haʻawina hoʻohālikelike hulahula me ka ʻikepili i ka teratogenicity i nā nui a me nā mea ʻoliva me ka hoʻomalu sc sc o ka insulin (insulin aspart a me insuline kanaka maʻamau) i hōʻike mai, ma ka laulā, ʻaʻole ʻokoʻa nā hopena o kēia mau insulins. ʻO ka aspart Insulin, e like me ka insulin kanaka, ma nā inaluna iʻoi aku o ka ʻōlelo no ka hoʻomālamalama ʻokoʻa i loko o nā kānaka e nā manawa he 32 (mau māmā) a me 3 mau manawa (nāʻu), i hoʻolilo i ka hala o ka mua a me ka post-implantation, a me nā abnormalities visceral / skeletal. I nā poho ma mua o ka ʻōlelo no ka hoʻomāluulu ʻana i ka subcutaneous i loko o nā kānaka e pili ana i 8 mau manawa (mauʻu) a i ʻole e like me nā dosis i loko o nā kānaka (nā manu), ʻaʻohe hopena koʻikoʻi.

Hiki paha ke hoʻohana ʻia inā hiki ke loaʻa ka hopena kūpono o ka ʻoi ma ka hiki o ka maʻi o ka pēpē (ʻaʻole i mālama ʻia nā haʻawina kūpono ʻia. ʻAʻole i ʻike ʻia inā hiki i ka insulin aspart biphasic ke loaʻa kahi embryotoxic i ka wā i hoʻohana ʻia i ka wā hāpai a inā paha e pili pū ana i ka hiki ke hānau.

I ka wā o ka hoʻomaka ʻana o ka hāpai ʻana a i kēlā wā holoʻokoʻa, pono ia e nānā pono i ke ʻano o nā mea maʻi me ka maʻi mellitus a nānā i ka pae o ka glucose i loko o ke koko. Ka pono o ka insulin, ma ke ʻano he kānāwai, e ho'ēmi i ka trimester mua a hoʻonui pinepine i ka trimesters lua a me ke kolamu o ka hapai.

I ka wā hānau keiki a ma hope koke o lāua, hiki i ka nui o ka insulin ke hoʻemi nui a hoʻomāhuahua, akā hoʻi koke i ka pae ma mua o ka wā hapai.

ʻAʻole i ʻike ʻia a komo paha ka lāʻau i ka waiū umauma. I ka wā lactation, hiki i kahi pono e hoʻoponopono i ka dosis.

Nā hopena maikaʻi o ka waiwai Insulin aspart biphasic

ʻO ka edema a me ka hewa reignive (i ka wā i hoʻomaka ai ka mālama ʻia), nā kūloko kūloko kūloko (hyperemia, ʻāʻī, hōʻeha o ka ʻili ma ka wahi i ʻōlelo ʻia), ka maʻi kūloko kūloko nui a me ka puhaka, hōʻeha, hoʻonui kahe, ka hana gastrointestinal hana, paʻakikī ka hanu, ka tachycardia, ka hoʻemi ʻia o ke koko, angioedema edema), lipodystrophy ma ka wahi ʻōlelo.

Hoʻohui

O ka laiki hypoglycemic oral, inhibitor MAO, inhibitor ACE, carbonic anhydrase inhibitors, bromocriptine, somatostatin analogs (octreotide), sulfanilamides, anabolic steroidids, tetracyclines, phenoxyfenfilfindofilfinfilofinfilofinfetinfinfizolofinfinfancing effinly of the syndrome effinly the syndrome nā huaʻōlelo a me nā ethanol.

Contraceptives oral, glucocorticoids, thyroid hormone, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazole, BKK, diazoxide, morphine, phenytoin, nicotine nawaliwali i ka hopena hypoglycemic o insulin. Ma lalo o ka mana o nā beta-blockers, clonidine, hoʻomākaukau lithium, reserpine a me salicylates, ʻelua nāwaliwali a me ka hoʻonui ʻana ma ka hana.

Ke keu

ʻAʻohe ʻikepili ma ka overdose o ka lāʻau lapaʻau. Ua manaʻoʻiʻo ia ka hoʻohana ʻana o kēlā me kēia lā i nā nui nui o kekahi mea hiki i ke kūkulu ʻana i neoplasms malignanta i ʻole ka lolo.

Hoʻohui

ʻAʻole pū ka mea kanu me nā lāʻau like ʻole.

Kūlana o ke kūʻai aku

ʻAʻohe kumu ʻike.

Nā kūlana mālama

Nā ʻōlelo kikoʻī

I ka wā lōʻihi o ka mālama ʻana, hoʻopau ka mea i nalo a haʻalele i kāna ono momona.

No ka hoʻoluhi kaumaha

E951 pinepine i loko o nā mea inu meaʻai. Me kēia paena hiki iā ʻoe ke kāohi i ka paona.

I ka wā hāpai a me ka lactation

Mākaukau e loaʻa ana (Analogs)

Palapala ʻia ia mea i loko o nā inoa kālepa i hala iho nei: Sugafri, AminoSweet, Spoonful, NutraSweet, Canderel.

Hōʻike ʻia nā hōʻike o ka aspart insulin lāʻau, e like me ka pauku ʻana i ke olakino, i kapa ʻia "synonyms" - nā mea hoʻololi i hiki ke hoʻololi ʻia i hoʻokahi o nā mea kaha a ko lākou mau hopena ma ke kino. Ke koho ʻana i nā unuhi, e noʻonoʻo wale ʻaʻole i kā lākou kumukūʻai, akā no ke aupuni o ka hana a me ka maikaʻi hoʻi o ka mea hana.

ʻO ka wehewehe ʻana i ka lāʻau lapaʻau

Hoʻopili pū kekahi me kahi receptor kūikawā ma ka membone cytoplasmic o waho o nā pūpū a hana i kahi mea hoʻohui insulin-receptor e hoʻoikaika i nā hanana intracellular, e komo synthesis o kekahi o nā kīʻaha koʻikoʻi (hexokinase, pyruvate kinase, glycogen synthetase). Hoʻohui ka hopena hypoglycemic me ka nui o ka holo intracellular a me ka hoʻonui ʻana i ka hoʻoliʻi o ka glucose ma o nā kiko, hoʻoulu ʻana i ka lipogenesis, glycogenogenesis, a me kahi ka emi o ka hōʻaia o ka hana glucose e ka ʻāʻī.

ʻO ka ʻaina Insulin a me ka insulin kanaka like like i ka hana like me ka molar like.

Hoʻokomo ka aspart Insulin mai ka momona o ka subcutaneous me ka wikiwiki a ʻoi aku ka wikiwiki ma mua o ka insulin soluble kanaka.

ʻO ka lōʻihi o ka hana o ka insulin aspart ma hope o ka hoʻokele sc me ka liʻiliʻi ma mua o ka hoʻomehana ʻana i ka insulin kanaka.

Kahi papa inoa o nā kūmole

E makaʻala! Aia ka papa inoa i nā huaʻōlelo no ka Insulin aspart, kahi ʻano like, no laila hiki iā ʻoe ke koho i kahi neʻe iā ʻoe iho, me ka nānā ʻana i ke ʻano a me ka ʻano o ka lāʻau lapaʻau i kauoha ʻia e kāu kauka. E hāʻawi i ka makemake i nā mea hana mai ka USA, Japan, Western Europe, a me nā ʻoihana maikaʻi loa mai ʻEulopa Hui Pū ʻIa: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Nā hopena hōʻike ʻike malihini

Ua hōʻike kekahi kipa i ka hana

Ua kipa kekahi kipa i kahi kumukūʻai kumukūʻai

Nā lālā	%
ʻĀina	1	100.0%

Elima mau malihini kipa i hōʻike mai i nā helu intake i kēlā

Ehia mau e lawe ai i ka aspart insulin.
ʻO ka hapanui o nā mea pane i hana pinepine i kēia lāʻau lapaʻau i nā manawa 3 i ka lā. Hōʻike ka hōʻike i ka pinepine o nā mea pane e lawe i kēia lāʻau lapaʻau.

Nā lālā	%
3 mau lā i ka lā	2	40.0%
4 lā i ka lā	2	40.0%
2 mau lā i kahi lā	1	20.0%

Elima mau malihini kuhi i ka helu ana

Nā lālā	%
1-5mg	3	60.0%
11-50mg	1	20.0%
51-100mg	1	20.0%

Ua hōʻike aku kahi mea kipa i kahi lā pau

Pehea ka lōʻihi e lawe ai i ka aspart insulin e manaʻo ai i ka holomua o ke kūlana o ka mea maʻi?
ʻO ka poʻe ʻikepili o ka hōʻike hōʻike i nā hapa he nui ma hope o ka hebedoma i loaʻa i kahi holomua. Akā ʻaʻole paha e kūpono kēia i ka manawa āu e hoʻomaikaʻi ai. E nīnau aku i kāu kauka no ka lōʻihi o kou makemake e lawe i kēia lāʻau lapaʻau. Hōʻike ka papa ma lalo nei i nā hopena o ka noiʻi ma ka hoʻomaka ʻana o kahi hana kūpono.

Hoʻokipa kekahi kipa i kahi manawa lohi

ʻO ka manawa hea ʻoi aku ka maikaʻi o ka lawe ʻana i ka mea kuhi Insulin: ma kahi ʻōpū ʻole, ma mua, ma hope a i ʻole me ka meaʻai?
Hoʻomaopopo pinepine nā mea hoʻohana o ka pūnaewele e lawe nei i kēia lāʻau lapaʻau ma hope o ka papaʻaina. Eia naʻe, hiki i ke kauka ke ʻōlelo aku i kahi manawa ʻē aʻe. Hōʻike ka hōʻike ʻana i ka wā i lawe ai ke koena o nā mea maʻi i ka lāʻau lapaʻau.

Ua hōʻike aku ʻekolu kipa i nā makahiki ahonui

Hōʻike nā kipa

ʻAʻohe ʻike ʻike

Nā ʻōlelo kuhikuhi i ka hoʻohana ʻana

NOVORAPID® PENFILL® (NOVORAPID® PENFILL®)

Ka helu helu helu:

Nā palapala ʻano:

Hoʻolaha hui:

Lapaʻa lāʻau:

Nā hōʻailona no ka hoʻohana ʻana:

Nā pālua:

Nā ʻoslelo a me ke hoʻoponopono:

ʻElua hopena:

ʻO nā maʻi ʻino e nānā ʻia ana i nā maʻi e hoʻohana nei iā NovoRapid® Penfill® ma muli o ka hopena pharmacological o ka insulin.
ʻO ka hopena maʻamau e hōʻike ai no ka hypoglycemia. Ka loli ʻana o ka hopena o ka hopena e pili ana i ka heluna o ka mea maʻi, ka hoʻoponopono o ka doses, a me ka kontrol glycemic (e ʻike i ka ʻāpana ma lalo).
I ka hoʻomaka mua o ka inika insulin, nā hewa reactive, edema a me nā hopena e hiki mai ana ma ka pūnaewele injection (pain, redness, hives, inflammation, hematoma, ka ʻōpū a me ka ʻeha i ka pūnaewele injection). Hoʻopili iki kēia mau ʻōuli i ke ʻano. Hiki i ka hoʻomaikaʻi wikiwiki ʻana i ka mālama glycemic ke alakaʻi i kahi kūlana o ka "neuropathy eha ʻeha," i ʻeli pinepine ʻia e ia. Ka hoʻonāukiuki ʻana o ka inikini insulin me ka hoʻomaikaʻi koʻikoʻi i ka kaohi o ka mea laʻala kalaiwa hiki ke alakaʻi i kahi wā pōkole i ke kūlana o ka maʻi retinopathy maʻi, ʻoiai ka lōʻihi o ka hoʻomaikaʻi ʻana i ka glycemic control hōʻemi i ka hopena o ka holomua o ka maʻi retinopathy diabetes.
Hōʻike ʻia ka papa inoa o nā hana ʻino i ka papaʻaina.

Hoʻokomo ʻia kahi ʻōnaehana Pūnaewele	ʻOhiʻeha - Hives, rashes, ʻili pali
Kuhi hewa loa - Anaphylactic reaction *
ʻO ka huʻihuʻi me ka meaʻaiʻaiʻai	Loaʻa pinepine - Hypoglycemia *
ʻO nā maʻi o ka pūnao	Aele loa - peripheral neuropathy ("ʻoiʻi ka maʻi neuropathy ʻeha")
Kuee ʻia o nā io o ka ʻike	Kekahi - hanaʻole o ka hoʻopaʻi
ʻO ka pinepine - retinopathy diabetic
Nā maʻi hōʻeha o ka ʻili a me ke kiko	Kanaluhi - lulax *
ʻO nā maʻi maʻamau a me nā maʻi i ka pūnaewele injection	Hoko - nā luhi ma ka wahi i ʻōlelo ʻia
Loaʻa - edema

* E nana aku "Ka wehewehe ʻana i nā kūʻokoʻa pili hewa"
ʻO nā hopena ʻino loa i hōʻike ʻia ma lalo nei, e pili ana i ka ʻike hoʻokolohua hoʻonaʻauao, e ʻāʻawale ʻia e like me ke alualu ʻana i ka hanana e like me MedDRA a me nā ʻōnaehana organ. ʻO ka hoʻāliʻi o nā hopena ʻino e wehewehe ʻia ma: pinepine pinepine (≥ 1/10), pinepine pinepine (≥ 1/100 a. Hana hana Pharmacological - hypoglycemic.

Hoʻopili ʻo ia me nā mea nānā aku o ka membone cytoplasmic o nā pā a hoʻāla i ka pūhui insulin-receptor e hoʻoikaika i nā hanana intracellular, e komo pū ana synthesis o kekahi o nā kīʻaha koʻikoʻi (hexokinase, pyruvate kinase, glycogen synthetase). ʻO ka emi ʻana o ke kao o ka glucose i ka koko ma muli o ka hoʻonui ʻana i kāna kaʻi intracellular, hoʻonui i ka hoʻowalewale ʻana e nā ʻūluna a me nā kiko adipose, a me ka emi ʻana o ka hōʻemi o ka hana glucose i loko o ka ate. ʻO ia ka hana like me ke insulin kanaka i nā molar kūlike. ʻO ka hoʻoneʻe ʻana o ka hinu waikawa amino ma ke kūlana B28 me ka waikawa aspartic e hōʻemi ana i ka ulu ʻana o nā molekala e hoʻokumu i ka hexamers i ka hapa wai o nā lāʻau lapaʻau, i ʻike ʻia i ka soluble insulin kanaka. I kēia hana, ua hoʻoneʻe ʻia ka aspart insulin mai ka momona subcutaneous ma mua o ka soluble insuline i loaʻa i ka insulin kanaka biphasic. Hoʻokomo hou ka Insulin aspart protamine. Ma hope o ka hoʻomalu sc, hoʻomohala ka hopena ma hope o 10-20 mau minuke, ka hopena loa - ma hope o nā hola 1-4, ka lōʻihi o ka hana - a hiki i ka 24 hola (e pili ana i ke ʻano, ka wahi o ka hoʻokele ʻana, ka ikaika o ke kahe, ke ʻano o ke kino a me ka pae o ka hana kino).

Ke hoʻo / i ka hoʻomaka ʻana o kahi huaʻai o 0.2 PIECES / kg o ke kino koʻikoʻi T max - 60 mau minuke Hoʻololi loa ka hoʻopaʻa ʻana i nā protein koko (0-9%). ʻO ka hoʻoneʻeʻana o ka insulin serum e hoʻi i ka mea hele ma hope o nā hola 15-18.

Ka hoʻohana ʻana o ka waiwai Insulin aspart biphasic

ʻO ka maʻi mellitus type type 1 (ka hihia i ka kūlohelohe i nā hopena hypoglycemic waha, ke kū'ē i ka pale ʻana i kēia mau lāʻau i ka wā e hui pū ai, me nā maʻi kūlohelohe).

Nā Hoʻohui

Wāwī palapala noi

ʻAe a i luna o 18 mau makahiki (ʻaʻole i hoʻoholo ʻia ka palekana a me ka pono).

ʻŌpū a me ka lactation

ʻAʻole i hoʻokō ʻia nā hana hoʻouluulu holoholona me ka hoʻohana ʻana i ka insulin aspart biphasic. Eia nō naʻe, nā haʻawina hoʻohālikelike hulahula me ka ʻikepili i ka teratogenicity i nā nui a me nā mea ʻoliva me ka hoʻomalu sc sc o ka insulin (insulin aspart a me insuline kanaka maʻamau) i hōʻike mai, ma ka laulā, ʻaʻole ʻokoʻa nā hopena o kēia mau insulins.ʻO ka aspart Insulin, e like me ka insulin kanaka, ma nā inaluna iʻoi aku o ka ʻōlelo no ka hoʻomālamalama ʻokoʻa i loko o nā kānaka e nā manawa he 32 (mau māmā) a me 3 mau manawa (nāʻu), i hoʻolilo i ka hala o ka mua a me ka post-implantation, a me nā abnormalities visceral / skeletal. I nā poho ma mua o ka ʻōlelo no ka hoʻomāluulu ʻana i ka subcutaneous i loko o nā kānaka e pili ana i 8 mau manawa (mauʻu) a i ʻole e like me nā dosis i loko o nā kānaka (nā manu), ʻaʻohe hopena koʻikoʻi.

Hiki paha ke hoʻohana ʻia inā hiki ke loaʻa ka hopena kūpono o ka ʻoi ma ka hiki o ka maʻi o ka pēpē (ʻaʻole i mālama ʻia nā haʻawina kūpono ʻia. ʻAʻole i ʻike ʻia inā hiki i ka insulin aspart biphasic ke loaʻa kahi embryotoxic i ka wā i hoʻohana ʻia i ka wā hāpai a inā paha e pili pū ana i ka hiki ke hānau.

I ka wā o ka hoʻomaka ʻana o ka hāpai ʻana a i kēlā wā holoʻokoʻa, pono ia e nānā pono i ke ʻano o nā mea maʻi me ka maʻi mellitus a nānā i ka pae o ka glucose i loko o ke koko. Ka pono o ka insulin, ma ke ʻano he kānāwai, e ho'ēmi i ka trimester mua a hoʻonui pinepine i ka trimesters lua a me ke kolamu o ka hapai.

I ka wā hānau keiki a ma hope koke o lāua, hiki i ka nui o ka insulin ke hoʻemi nui a hoʻomāhuahua, akā hoʻi koke i ka pae ma mua o ka wā hapai.

ʻAʻole i ʻike ʻia a komo paha ka lāʻau i ka waiū umauma. I ka wā lactation, hiki i kahi pono e hoʻoponopono i ka dosis.

Nā hopena maikaʻi o ka waiwai Insulin aspart biphasic

ʻO ka edema a me ka hewa reignive (i ka wā i hoʻomaka ai ka mālama ʻia), nā kūloko kūloko kūloko (hyperemia, ʻāʻī, hōʻeha o ka ʻili ma ka wahi i ʻōlelo ʻia), ka maʻi kūloko kūloko nui a me ka puhaka, hōʻeha, hoʻonui kahe, ka hana gastrointestinal hana, paʻakikī ka hanu, ka tachycardia, ka hoʻemi ʻia o ke koko, angioedema edema), lipodystrophy ma ka wahi ʻōlelo.

Hoʻohui

O ka laiki hypoglycemic oral, inhibitor MAO, inhibitor ACE, carbonic anhydrase inhibitors, bromocriptine, somatostatin analogs (octreotide), sulfanilamides, anabolic steroidids, tetracyclines, phenoxyfenfilfindofilfinfilofinfilofinfetinfinfizolofinfinfancing effinly of the syndrome effinly the syndrome nā huaʻōlelo a me nā ethanol.

Contraceptives oral, glucocorticoids, thyroid hormone, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazole, BKK, diazoxide, morphine, phenytoin, nicotine nawaliwali i ka hopena hypoglycemic o insulin. Ma lalo o ka mana o nā beta-blockers, clonidine, hoʻomākaukau lithium, reserpine a me salicylates, ʻelua nāwaliwali a me ka hoʻonui ʻana ma ka hana.

Ke keu

Nā Hoʻomaka hypoglycemia - ka 'anuō "ka pehu, ka palupalu o ka ʻili, nā hopohopo, keehi nui, ka hopohopo, nāwaliwali ʻole, nāwaliwali, ka hōʻeha ʻana, ka hopohopo, ka wīwī nui, ka pōloli, ka pōkole o ka nānā ʻana i ke poʻo, ka nausea, ka tachycardia, nā hoʻopihapiha, nā neurological maʻi. koma.

Lāʻau: hiki i ka mea maʻi ke pani i ka hypoglycemia liʻiliʻi ma o ka lawe ʻana i ka glucose, ke kō a me nā meaʻai momona paha i loko. Ma nā hihia koʻikoʻi - i / in 40% hopena dextrose, i / m, s / c - glucagon. Ma hope o ka loaʻa hou ʻana i ka ʻike, ʻike ʻia ka mea maʻi e ʻai i nā meaʻai momona a keu e pale ai i ka hoʻomohala ʻana o ka hypoglycemia.

ʻO ka mālama mea hoʻomehana insulin aspart biphasic

ʻAʻole hiki iā ʻoe ke komo iv. Hiki i kahi waiole ʻole a i ʻole ke kāpae ʻana i ka mālama ʻana (me ka nui o ka type 1 diabetes mellitus) hiki ke alakaʻi i ka hoʻomohala ʻana o ka hyperglycemia a i ʻole ketoacidosis maʻi maʻi. Ma ke ʻano he lula, hōʻike ka maʻi hyperglycemia iā ia iho, i mau hola a i ʻole mau lā (nā hōʻailona o ka hyperglycemia: nausea, ka luaʻi, ka ʻalike, ʻulaʻula a me ka maloʻo ʻana o ka ʻili, ka waha maloʻo, hoʻonui i ka hopena o ka urine, makewai a me ka nalowale o ka makemake, ka helehelena o kahi ʻano o ka acetone i loko o ka ea hanu). a inā ʻaʻole kūpono kūpono hiki iā ia ke make i ka make.

Ma hope o ka hoʻokolohua ʻana i ka momona o ka metabolism, no ka laʻana, me ka hoʻomehana ʻana o ka insulin, hiki i nā mea maʻi ke ʻike i nā ʻano maʻamau o ka poʻe o ka neʻe o ka hypoglycemia, kahi e ʻike ʻia ai ka poʻe maʻi. I ka maʻi me ka maʻi diabetes me ka hoʻokolohua metabolic maikaʻi, ʻo nā hopena hoʻopiʻi o ka maʻi maʻi i hoʻomohala ma hope a holomua hou. Ma kēia mea, pono ia e hana i nā hana i kuhikuhi e pili ana i ka kāohi ʻana o ka metabolic control, me ka mālama ʻana i ka pae o ka glucose i ke koko.

Pono e hoʻohana ʻia ka lāʻau lapaʻau i ka pili pono me ko ka meaʻai o ka meaʻai. He mea pono e noʻonoʻo i ka helu kiʻekiʻe o ka hoʻomakaʻana i ka hopena ma ka mālamaʻana i nā mea maʻi me nā maʻi concomitant a lawe ʻole i nā lāʻau lapaʻau e hoʻolōʻihi i ka hoʻohemo ʻana o ka meaʻai. Ke hele nei i nā maʻi concomitant, ka mea nui o ka ʻano maʻi o ka maʻi hopohopo, he nui ka ulu ʻana o ka insulin. ʻO ka hana a i ʻole ka lau a me ka hana nūia hiki ke alakaʻi i ka hōʻemi i nā koi o ka insulin. Hōʻalo i ka ʻai a i ʻole hana i hoʻolālā ʻia ke alakaʻi i ka hoʻomohala ʻana o ka hypoglycemia.

ʻO ka hoʻoneʻe ʻana o ka mea maʻi i kahi ʻano insulin a i ʻole ka hoʻomākaukau ʻana i ka insulin i kahi mea hana ʻē aʻe e pono e hana ma lalo o ka mākaʻi ʻana o nā lāʻau lapaʻau, ʻokoʻa paha ka hoʻoponopono ʻana. Inā pono, hiki ke hoʻoponopono ʻia nā lāʻau lapaʻau i ka manawa mua o ka lāʻau o ka lāʻau a i ʻole ma mua o nā hebedoma mua a i ʻole nā ​​mahina o ka mālama ʻana. Hiki ke loli me ka loli i ka ʻai ʻana a me ka hoʻoikaika kino kino. Hiki i ka hoʻomaʻemaʻe koke ʻana ma hope o ka ʻai e hiki ke hoʻonui i kou pilikia o ka hypoglycemia.

Me ka hoʻomohala ʻana o ka hypoglycemia a i ʻole hyperglycemia, he hiki ke emi ana i ka ʻike o ka nānā ʻana a me ka wikiwiki ka wikiwiki, hiki i ka pilikia ke keehi aku i ka kaʻa a hana paha me nā mīkini a me nā mīkini. Pono e kuhikuhi ʻia nā mea maʻi e hana i nā hana e pale ai i ka hoʻomohala ʻana o ka hypoglycemia a me ka hyperglycemia. He mea koʻikoʻi kēia no nā mea maʻi me ka ʻole a hōʻemi iki paha i nā hōʻailona o nā mea hana mua i ka hoʻomohala ʻana i ka hypoglycemia a i ʻole ka hōʻeha ʻana i nā manawa pinepine o ka hypoglycemia.

I ka wā e hoʻohana ai i nā lāʻau, he mea nui loa ia e hoʻomaopopo i kā lākou kumu o kā lākou hana. Hiki i nā lāʻau lapaʻau ke hoʻopōʻino inā hoʻohana pono ʻole. Kēia maoli kēia no nā lāʻau lapaʻau i hoʻohana ʻia i loko o nā ala āpau e lawe i ka hopena kino.

Hoʻopili kēia me nā lāʻau lapaʻau e pili ana i ka insulin. I waena o lākou aia kahi insulin e kapa ʻia ʻo Aspart. Pono ʻoe e ʻike i nā hiʻohiʻona o ka hormone, no laila ʻo ka mālama ʻana me ia e hiki ke ʻoluʻolu loa.

Hoike ʻike

ʻO ka inoa kālepa kālepa o kēia lāʻau ʻo NovoRapid. Aia ia ma ka helu o nā insulins me kahi hana pōkole, e kōkua i ka hōʻemi o ka nui o ke kō i loko o ke koko.

Kuhi aku nā kauka i nā maʻi i ka maʻi diabetes-hilinaʻi. ʻO ka mea ikaika o ka lāʻau lapaʻau ka insulin Aspart. Hoʻohālike loa kēia ʻano i kona mau waiwai i ka hormone kanaka, ʻoiai ua hua ia me ka chemically.

Loaʻa ka Aspart i ke ʻano o ka hopena e lawelawe ʻia kahi e kū hoʻokahi a i ʻole intravenously. Aea? Aaeaa aae? Aaeaa iaeaaeaaaiea eaeinaa? A (aaeoe ae? Aneee i? Ehiaiai / iacaiee ia aeae? Aneaaoea.

ʻO kaʻoi aku i nā mea nui, i waena o kāna mau māhele e hiki ke kapa ʻia:

• wai
• fenol
• sodium klorida
• glycerol
• hoʻohuihui hanehana
• sodium hydroxide
• zinc
• metacresol
• sodium hydrogen phosphate dihydrate.

Hāʻawi ʻia ka Insulin Aspart i nā pahu kele he 10 ml. Hoʻohana ʻia kona hoʻohana ʻana e like me ka mea i kuhikuhi ʻia e ke kauka hele a e like me nā ʻōkuhi.

ʻO nā waiwai Pharmacological

Loaʻa i ka asparta kahi hopena hypoglycemic. Hana ia i ka wā e hoʻopili ai ka mea ikaika me ka receptors i loko o nā pūpū o ka iwi adipose a me nā mea naʻau.

Pākuʻi kēia i ka hoʻokele o ka hoʻoili o ka glucose ma waena o nā sela, kahi e hoʻemi ai i kona neʻe ʻana i ke koko. Mahalo i kēia lāʻau lapaʻau, hoʻohana ʻo nā kino kino i ka glucose i kahi wikiwiki hou.ʻO kekahi ʻaoʻao o ka hopena o ka lāʻau lapaʻau e hoʻolōʻihi i ke kaʻina o ka hana glucose i loko o ka ate.

Hoʻonui ka lāʻau i ka glycogenogenesis a me nā lipogenesis. Eia kekahi, ke hoʻopau ʻia, hana ikaika ka protein.

Hoʻohālikelike ʻia e ka assimilation wikiwiki. Ma hope o ka hana ʻana i ka hoʻonā, ua hoʻihoʻi ʻia nā mea ikaika e nā ʻāpana o ke kiko o ka ʻiʻo. Hoʻomaka kēia kaʻina 10-20 mau minuke ma hope o ka loaʻa ʻana. Loaʻa ka hopena ikaika loa ma hope o nā hola 1,5-2. ʻO ka lōʻihi o ka hopena o ka lāʻau lapaʻau ma ka laulā he 5 mau hola.

ʻO ka hoʻopiliʻana i ka lāʻau, overdose, analog

Ke lawe nei i kekahi lāʻau lapaʻau, pono ia e hōʻike i ke kauka hele e pili ana iā lākou, no ka mea ʻaʻole pono e hoʻohana pū ʻia kekahi mau lāʻau lapaʻau.

I nā kūlana ʻē aʻe, e pono ke mālama ʻia - ka mālama mau ʻana a me ka nānā ʻana. Aia aia paha he pono no ka hoʻoponopono hoʻoponopono ʻia.

Pono e hoʻemi ʻia ka hopena o ka insulin Aspart i ka wā e mālama ai me nā lāʻau lapaʻau e like me:

• nā lāʻau lapaʻau hypoglycemic,
• nā mea kanu me ka waiʻona
• steroids anabolic
• ACE paleai
• pālahalaha
• sulfonamides,
• Fenfluramine,
• ʻO Pyridoxine
• Theophylline.

Ke hoʻoikaika nei kēia mau lāʻau i ka hana o ka lāʻau lapaʻau e nīnau ʻia ana, ʻo ia ke kumu e hoʻonui nui ʻia ai ke kaʻina o ka hoʻohanaʻana i ka glucose i loko o ke kino o ke kanaka. Inā ʻaʻole hōʻemi ʻia ka nui o ka maʻa, hiki i ke hypoglycemia.

Hoʻopili ʻia ka hopena o ka lāʻau i ka wā e hui pū ai me ka ʻaina penei:

• thiuretics
• haluluHalakalaha
• kekahi mau ʻano antidepressants,
• hoʻonaʻauao hormonal,
• glucocorticosteroids.

Ke hoʻohana nei iā lākou, pono ia i kahi hoʻoponopono i luna.

Aia kekahi mau lāʻau lapaʻau e hiki ke hoʻonui a hoʻēmi i ka maikaʻi o kēia lāʻau lapaʻau. Hoʻopili kēia ma ka salicylates, beta-blockers, reserpine, nā lāʻau lapaʻau e pili ana i ka lithium.

Mālama pinepine kēia mau kālā e hui pū me ka insulin Aspart. Inā ʻaʻole hiki ke hoʻokaʻawale kēia hui, pono e mālama pono ke kauka a me ka mea maʻi i nā hopena i kū i loko o ke kino.

I ka hihia o kahi overdose, hypoglycemia o kēlā me kēia ʻano paʻakikī. I kekahi mau manawa, hiki i ka punahele momona a i kahi mea kapu paha ke hānai i nā hōʻailona.

I kahi kūlana paʻakikī, hiki i ka mea maʻi ke nalowale. I kekahi manawa ulu ulu ka hypoglycemic coma. A laila e pono ana ka mea maʻi i ka mālama olakino kiʻekiʻe a kiʻekiʻe hoʻi, inā ʻaʻole ʻo ka hopena kona make ʻana.

Hiki i ka pono ke hoʻololi i ka Aspart ma muli o nā kumu like ʻole: intolerance, ʻaoʻao effects, contraindications a inconvenience of use.

Hiki i ke kauka ke hoʻololi i kēia pono me nā lāʻau lapaʻau aʻe:

1. Protafan . ^ E Ha yM. ʻO ka kumu o ka Isofan insulin. ʻO ka lāʻau lapaʻau he hoʻopanee e pono ai e lawelawe ʻia subcutaneously.
2. Novomiks . ^ E Ha yM. Hoʻokumu ʻia ka lāʻau lapaʻau i ka insulin Aspart. Hoʻohui ʻia ia ma ke ʻano he kaia o ka hoʻokele ma lalo o ka ʻili.
3. Apidra . ^ E Ha yM. ʻO ka lāʻau lapaʻau ka hoʻonā ʻana. ʻO kāna kumu hana o ka glulisin insulin.

Hoʻopiliʻia i nā lāʻau lapaʻau injectable, hiki i ke kauka ke kuhikuhi a papa i nā lāʻau lapaʻau. Akā he pono ke koho ma ka loea no laila ʻaʻole i nā pilikia olakino hou.

Lapaʻau

Hoʻopili ia i nā ʻenikena insulin ma nā pūpū a me nā momona momona. ʻO ka emi ʻana o ke kaʻe o ke koko no ka hoʻonui ʻana i ka halihali intracellular, hoʻonui i ka hoʻohana ʻana i ka iwi, a me ka hoʻohaʻahaʻa ʻana o ka hōʻemi o ka hana glucose i loko o ka ate. Hoʻonui i ka uluʻana o ka lipogenesis a me ka glycogenogenesis, ka synt synt synt. Ma hope o ka hoʻolilo iā sc sc, e kūpono ka hopena i loko o 10-20 mau minuke, hiki i ka lōʻihi ma hope o nā hola 1-3 a kū i ka hola 3-5.

Hoʻopili koke ʻia mai ka momona subcutaneous. ʻO ka hoʻoneʻe ʻana o ka hinu waikawa amino ma ke kūlana B28 me ka waikawa aspartic e hōʻemi ana i ka ulu ʻana o nā molekala e hoʻokumu i ka hexamers, e hoʻonui ana i ka helu o ka absorption (hoʻohālikelike i ka insulin kanaka maʻamau).Ma hope o ka hoʻokele s / c, ʻo T max ka 40-50 mau minuke, emi loa ka paʻa ʻana i ka protein (0-9%), ʻo T 1/2 - 81 mau minuke.

Carcinogenicity, mutagenicity, hopena i ka mahele

ʻO nā haʻawina pili makahiki holoʻokoʻa e loiloi ana i ka hiki ʻana o ka carcinogenicity o ka ʻumi aspart ʻaʻole i hana. I loko o hoʻokahi mau noiʻi oncogenicity hoʻokahi makahiki, na maʻi ʻo Sprague-Dawley i hui ʻia i ka sc in insulin aspart ma nā papa o 10, 50, a me 200 mau kumuwaiwai / kg (he 2, 8 a he 32 mau manawa o ka maʻi kanaka i ka wā i mālama ʻia ai ka sc). Hōʻike nā hopena i kahi hapa o 200 mau ʻāpana / kg i nā wahine, ʻoi aku ke kiʻekiʻe o ka piʻi ʻana o nā umauma umauma i hoʻohālikelike ʻia i kēlā me kēia mau mea (ʻaʻole i ʻokoʻa kēia mau ʻike i nā mea i loaʻa me ka insulin kanaka maʻamau). ʻAʻole ʻike kahi ʻike o ka ʻikepili i loaʻa no nā kānaka.

ʻAʻole i ʻike ʻia ka mutagenity o ka insulin aspart i ka nui o nā hōʻike genotoxic (me ka hōʻike ʻana ʻo Ames, ka hōʻike no ka gen mutations a i nā cell lymphoma mouse, ʻo ka hōʻike no ka aberrations chromosome i loko o kahi moʻomehe lymphocyte kanaka), a me i vivo ma ka hōʻike ʻana o ka micronucleus i ka ʻiole a ex vivo i ka hōʻike UDS (hoʻopaʻa ʻole ʻia o ka synthesis DNA) ma luna o nā hepatocytes rat.

ʻAʻohe mea kīnā ʻole i loko o nā kaole kāne a me nā wahine i nā kao sc scart o ka insulin aspart, ma kahi o 32 mau manawa i hoʻolako ʻia no ka hoʻomalu sc sc i nā kānaka.

Ka hoʻonohonoho, hoʻokuʻu i ke ʻano a me ka hopena lāʻau lapaʻau

Hoʻopili ka insulin Biphasic i ka hoʻokaheʻana i ka Aspart a me ka protamine insulin crystalline ma kahi ratio o 30 a 70%.

He kānalua kēia no ka hoʻokele sc, me ka ʻula keʻokeʻo. 1 milliliter i loko o 100 mau pūʻulu, a i kahi hoʻokahi ED me ka 35 mcg o ka insulin phi anhydrous.

Kūkulu ka inika manuahi kanaka e hoʻopili ai i kahi mea paʻa o ka insulin me ka receptor ma ka membrane pūnaewele sela. Hoʻopili ka hope i ka synthesis o glycogen synthetase, pyruvate kinase a hexokinase enzymes.

ʻO ka emi ʻana o ke kō me ka hoʻonui me ka piʻi o ka halihali intracellular a me ka hoʻomaikaʻi ʻana i ka nui o ka glucose. Loaʻa ia ka hypoglycemia ma ka hoʻohaʻahaʻa ʻana i ka manawa no ka hoʻokuʻu i ka glucose ma o ke akeʻai, glycogenogenesis a me ka hoʻōlaʻana o ka lipogenesis.

Loaʻa ka Bartasic insulin aspart ma o ka hana biotechnological i ka wā e ke hoʻololi ʻia ka mololi o ka prole hormone e nā aspartic acid. ʻO kēlā mau insulins biphasic he hopena like i ka hemoglobin glycosylated, e like me ka insulin o ke kanaka.

ʻO nā lāʻau ʻelua e hoʻoikaika i ka kūlike molar. Eia naʻe, hana nui ka insulin o ka Aspart ma mua o ka hāmeʻa kanaka soluble. He crystalline aspart o ka protamine he hopena i ka wā lōʻihi.

Hana ʻia ka hana ma hope o ka hoʻomalu sc a me ka mākaia ma hope o 15 mau minuke. ʻO ka kao kiʻekiʻe loa o ka lāʻau lapaʻau e loaʻa i nā hola 1-4 ma hope o ka loaʻa ʻana. ʻO ka lōʻihi o ka hopena e piʻi i 24 mau hola.

I ka serum Cmax, ʻo ka insulin i ka 50% ʻoi aku ma mua o ka hoʻohana ʻana i ka insulin o ka biphasic. Eia kekahi, ʻo ka manawa maʻamau e hōʻea ma Cmax ma mua o ka hapalua.

T1 / 2 - a hiki i nā hola 9, e hōʻike ana i ka wikiwiki o ka loaʻa ʻana o ka hapa o ka protamine-bound. ʻIke ʻia nā pae insulin baseline i nā hola 15-18 ma hope o ka hoʻokele ʻana.

Akā me ke ʻano type type 2, ʻo ka loaʻa o Cmax ma kahi o 95 mau minuke. Mālama ia ma ka pae o lalo ma lalo o 14 a ma luna o 0 ka mākaʻi sc. Inā pili paha ke ʻano o ka hoʻokele i kahi pūnaewele o ka absorption.

ʻLoe a me ke kākele

Hōʻike pinepine i ka insulin Degludek, Aspart. Kahi ʻia ka hana ʻana i kekahi mau wahi o ke kino.

Pono ʻoe e hana i kahi inikini insulin ma mua o ka ʻai ʻana (ka hana prandial) a i ʻole ma hope o ka ʻai ʻana i ka meaʻai (ke ʻano postprandial).

Hoʻoholo ʻia ka algorithm a me ka helu o ka hoʻokele ʻana e ke kauka hele mai. Akā pinepine ka nui o kēlā me kēia lā i ka lā ʻo 0.5-1 UNITS i 1 kg o ka paona.

I nā pilikia koʻikoʻi, e lawelawe ka insulin Aspart biphasic iv. Hoʻoholo ʻia ke kaʻina hana me nā ʻōnaehana infusion i kahi hoʻonohonoho outpatient a inpatient paha.

ʻO nā hopena ʻino, contraindications a me ka overdose

Hiki i ka hoʻohana ʻana o ka insulin Asparta ke hoʻopilikia i ka hana a ka National Assembly, ʻoiai ka wikiwiki koke o nā waiwai gula i kekahi manawa e hoʻonāukiuki i ka neuropathy hōʻeha koʻikoʻi. Eia naʻe, ua hala kēia kūlana i ka manawa.

Eia pū kekahi, ʻo ka insulin biphasic e alakaʻi i ka hiʻohiʻona o lipodystrophy i ka pae injection. Ma ka ʻāpana o nā hui sensory, ʻike ʻia ka ʻike ʻana o ka ʻike maka a me nā hemahema ma ka hoʻihoʻi ʻana.

ʻO nā contraindlence kekahi kūloko pilikino i nā māhele o ka lāʻau a me ka hypoglycemia.

Eia kekahi, ʻaʻole e aʻo ʻia ke hoʻohana ʻana o Insulin Aspart a hiki i ka makahiki 18. No ka mea ʻaʻohe ʻikepili data e hōʻoia ana i ka pono a me ka palekana o ka lāʻau lapaʻau no ka mea hou i ke ola.

Ma kahi o kahi overdose, loaʻa nā hōʻailona like ʻole:

• nahoa
• ka hoemi nui ʻana o ka glucose,

Me ka hapa iki o ka hopena, e hoʻomaʻamaʻa i ke kukuna o ka glucose, ua lawa ia e lawe i nā kīmaki wikiwiki a inu paha i kahi mea momona. Hiki iā ʻoe ke komo i ka glucagon subcutaneously a i ʻole intramuscularly a i ʻole he hopena no ka dextrose (iv).

I ka hihia o ka hypoglycemic coma, mai 20 a 100 ml o ka dextrose (40%) ua hopu ʻia i kahi ʻano jet-intravenous a hiki i ke ʻano o ka maʻi o ka maʻi. I mea e pale ai i ka hoʻomohala ʻana o ia mau hihia, ʻoi aku ke hoʻonui ʻia i ka paʻakai hoʻoliʻi waha.

E hoʻokuʻu i ke ʻano

Hoʻokuʻu ʻia ka lāʻau lāʻau i kāna ʻano maʻa, a me kekahi ʻāpana o nā lāʻau lapaʻau paʻakikī. ʻO ka inoa kālepa no ka hoʻopauʻana i ka maʻi Aspart ʻo NovoRapid, ʻo ka inoa ʻelua o ka inoa ʻo NovoMix (30 FlexPen a Penfill, 70 a me 50 FlexPen) a me Raizodeg.

Hoʻokuʻu ʻia ka ʻikepili Insulin Aspart. INN (i ka ʻōlelo Latin) - Insulinum aspartum, ʻelua manawa - Insulinum aspartum biphasicum.

Nui a hewahewa nā pepa hoʻohālikelike, ka hana ikaika e waiho ai ka insulin aspart. Loaʻa i nā pahu kālena.

Ka awelika - 1700-1800 r no ka 3 ml o ka hopena hypoglycemic. Kūlike ke kumukūʻai ma ke ʻano o ke hoʻokuʻu.

Ma kahi hoʻomākaukau hana hoʻokahi he 350 μg o ka mea hana, e like me ka 100 PIECES.

Loaʻa ka hoʻonā biphasic i ka 30% insulin aspart a me 70% protamine ma ke ʻano crystalline.

ʻO ke ʻano o ke hoʻohana ʻana ma ke ʻano o ka lāʻau a me ke ʻano o ka endocrine pathology. Hoʻopilikia ʻia ka dosage e nā maʻi maʻi a me ke ʻano, ʻo ka makahiki o ka mea maʻi.

Nā ʻōkuhi no ka hoʻohana ʻana i ka Insulin Aspart:

• E mālama ʻia kahi mākōlio hoʻokahi bioengineering sc. Aia ma kahi o 0.5-1 mau pākahi no 1 kg o ke kaumaha o ke kino. Ua mahele ʻia ka ʻōlelo maʻamau i kēlā me kēia lā i kekahi mau noi, inā ʻaʻole e kū hou mai ka hypoglycemia, hiki i kēia ke hōʻola. Hoʻohana ʻia e lawelawe ma ke ʻano pilikino wale nō i nā limahana olakino, ka hoʻokele ʻana o ka iv i nā mea i hiki ke alakaʻi i nā hoʻopiʻi kūlana ʻole.
• Hoʻohana ʻokoʻa nā mea hoʻohana ʻokoʻa ʻelua. ʻO ka ʻōlelo mua he 12 mau ʻāpana, ke mālama ʻia ia i ka pō ma mua o ka ʻaʻa hope o ka ʻaina hope. Ua hoʻokomo ʻia i ka s / c, a i loko a me / i pāpā ʻia ka hoʻomaka. Ma hope o 3 mau lā, e hoʻoponopono ʻia ka nui o ka nui, me ka noʻonoʻo ʻana i ka pae ʻaina wikiwiki, kahi e ana ai ʻia i loko o 3 mau lā.

E hoʻokomo i ka lāʻau lapaʻau i loko o nā wahi lipodystrophic. ʻEkuhi ʻelua mau manamana lima i ka ʻili, hana i kahi kālai. Kahi i kahi inikua i hana ʻia i loko.

ʻO ka lawe ʻana i ka lāʻau lapaʻau i ka wā lactation ʻaʻole i pāpā ʻia. ʻAe ʻia ka hoʻohana inā he liʻiliʻi ʻole ka hopena o ka pēpē i ka pōmaikaʻi i ka makuahine.

I nā poʻe maʻi maʻi, he mea pono e hoʻoponopono i ke kūleʻa. ʻO nā loli e pili ana i nā makahiki i ke kino ke alakaʻi i ke olakino maikaʻi. Ma muli o ka hana ʻana o nā hana kūloko, ua pilikia ka ʻano o ka lāʻau lapaʻaka hypoglycemic.

ʻO nā lāʻau lapaʻau e hoʻohaʻahaʻa i ke kōpaʻa koko, kahi i lawe ʻia ma ke alo, e hoʻoikaika i ka hana o ka mea ikaika. ʻAʻole manaʻo ʻia nā lāʻau like ʻole. Hoʻokumu ka hypoglycemia, kahi kūlana i hōʻike ʻia e ka emi o ka glucose i lalo o nā kumu maʻamau.

ʻO nā mea anabolic anabolic, Ketoconazole, Pyridoxine a me nā lāʻau lapaʻau hou e pili ana i ka ethanol a me ka tetracyclines, i hoʻohana pū ʻia i kēia lāʻau lapaʻau hypoglycemic, e hana pū kekahi i ka hōʻemi i ka glucose koko.

ʻO nā contraceptives oral, heparin a me antidepressants i hoʻohana ʻia i ka mellitus maʻi diabetes e hōʻemi i nā hōʻailona o ke kolohe e hiki ke hōʻemi i ka hopena o ka lāʻau.

Hoʻolakoʻo ka hoʻonui ʻana i ka dosage no ka mea, ʻo ka wikiwiki o ka hoʻomanawanui o ka glucose i ka hoʻomaka o ka hana e hoʻoulu i nā hopena maikaʻi loa mai ka pūnaehana waena a me ke peripheral. Hoʻopilikia kēia i kahiʻano koʻikoʻi, kahi transcent i loko o ke ʻano.

Ma ka pūnaewele ʻōkuhi ka puka, a me ka ʻulaʻula. Ma ka mahele o ka ʻōnaehana ʻike, ʻike nā mea maʻi i ka aniseikonia. Hapaia ke ʻano, ʻo ia hoʻi, ke ʻano like nā mea like me mau retinas i ka ʻokoʻa. Hoʻihoʻi ʻia ka hopena ʻaoʻao.

Me ka hoʻolōʻihi ʻia i nā wahi ma kahi e ulu. Hiki iā ia ke pale aku inā hoʻololi ʻoe i ka wahi o ka hoʻokele o ka insulin i loko o ia wahi.

Kuhi ʻia nā hōʻike hypersensitivity liʻiliʻi. Ke ola nei lākou i ka maʻi maʻi hakahaka, ua hōʻike ʻia nā hihia.

Loaʻa nā lāʻau lapaʻau he contraindications. He mea nui ia e noʻonoʻo pono e pale aku iā ʻoe iho mai ka hoʻomohala ʻana mai o nā hopena maikaʻi ʻole makemake.

ʻO nā Insulin Aspart he liʻiliʻi contraindications. ʻO ka mea nui, ʻo ka manaʻo o ka mea maʻi i ka puʻuwai. Inā hele ʻole kahi ʻōpala i ka wā o ka hoʻohana mua ʻana, he wahi ʻulaʻula a i ʻulaʻula paha ka wahi o ka injection, ʻaʻole ʻae ʻia ka hoʻohana hou ʻana o ka lāʻau. Me ka hoʻohana hou ʻia, hiki ke hoʻonui ʻia ka hopena kūlohelohe.

Hoʻohana ʻia ka hoʻohana ʻana o ka lāʻau lapaʻau i ka wā o ka gestation. Pono ʻia ka nui o ka hewa. Ua hōʻike ʻia nā noiʻi he nui nā dosis nui o ka lāʻau lapaʻau i ka hopena maikaʻi ʻole i ka maʻi wahine.

Ka wai o ka insulin aspart a me ka nui

Hoʻokomo ʻia ka Insulin aspart subcutaneously, intravenously. ʻO ka subcutaneously, ma ka māhele o ka ʻōpū, ka pā o ka ʻōpū, pihi, ʻūhā koke ma hope o ka ʻai (postprandial) a i ʻole ma mua o ka ʻai (prandial). Pono e hoʻololi pinepine i ka pae injection i loko o kēlā wahi o ke kino. Hoʻonohonoho ʻia ke ʻano o ka hoʻokele ʻana a me ka helu. ʻO ka maʻamau, ʻo ka pono o ka insulin ka 0.5 - 1 PIECES / kg i kēlā me kēia lā, 2/3 o ka hāʻule i ka prandial (ma mua o ka ʻai) insulin, 1/3 - ma ke ʻano (basal) insulin.
Hoʻokaʻawale ʻia ka intravenously inā pono, me ka hoʻohana ʻana o nā ʻōnaehana infusion, kahi mea hoʻolaha maikaʻi wale nō e hiki ke lawe ʻia e nā limahana lapaʻau mākaukau.
Me ka hoʻopauʻole o ka hopena a i ʻole kahi hapa pono (ʻoi aku paha me ka type 1 diabetes mellitus), hiki i ka hyperglycemia a me ke ketoacidosis maʻi maʻi. Hoʻokomo pinepine ka Hyperglycemia i nā hola he nui a i ʻole mau lā paha. Nā hōʻailona o ka hyperglycemia: nausea, ke kaumaha, ka luaʻi, ka maloʻo a me ka ulaula o ka ʻili, hoʻonui i ka hopena o ka urine, waha maloʻo, ka nalo o ka makemake, makewai, ka ʻano o ke ʻano o ka acetone i loko o ka hanu. ʻO ka Hyperglycemia me ke kūpono kūpono e alakaʻi ai i ka make.
I ka hihia o ka renal a i ʻole ka hana ʻana o ka hana maʻa, pono i emi iho ka nui o ka insulin, a i mua hoʻi o nā maʻi concomitant, ʻoi aku ka nui o ka maʻi maʻi, hoʻonui nui ʻia. ʻO ka maile o ke kīkē o ka pituitary, nā kūloko adrenal, a me nā kūlohelohe thyroid hiki ke hoʻololi i ka pono o ka insulin.
Pono ka kaohi o ka mea maʻi i kahi inoa inoa inoa a i ʻole ka ʻano o ka insulin.
Ke hoʻohana nei i ka insulin aspart, kahi loli a i ʻole ka helu o ka nui o nā inikini i kēlā me kēia lā e pono ai, e like me ka insulin maʻamau. Hiki ke koi ʻia ka hoʻoponopono ʻana ma ka ʻĀina mua.
I loko o nā mea maʻi ma hope o ka uku no ka hoʻonaninani o ka kalaka, hiki ke loli i kā lākou mau hōʻailona maʻamau o ka mea kūpono o ka hypoglycemia, pono e ʻike ʻia nā mea maʻi e pili ana i kēia.
Hoʻolālā ʻole a hoʻomaʻemaʻe paha i nāʻaina hiki ke alakaʻi i ka hypoglycemia.
Ma muli o nā hiʻohiʻona pharmacodynamic, hypoglycemia me ka hoʻohana ʻana i ka aspart insulin e ulu i mua ma mua o ka hoʻohana ʻana o soluble insulin kanaka.
No ka mea pono e hoʻohana ʻia ka aspart o ka insulin i ka pili pono me ka ʻaina o ka meaʻai, pono ia e noʻonoʻo pono i ka wikiwiki kiʻekiʻe o ka hoʻomaka ʻana o ka hopena o ka lāʻau lapaʻau ma ka mālama ʻana i nā mea maʻi e pili ana i nā ʻano kulekele, a lawe i nā lāʻau lapaʻau e hoʻolohi ana i ka komo ʻana o ka meaʻai.
ʻO ka mālamaʻana i ka insulin me ka hoʻonui maikaʻi ʻana i ka mālama glycemic hiki ke hele pū me ka hoʻomohala ʻana i ka maʻi neuropathy hōʻeha a me ka ulu ʻana o ke ʻano o ka maʻi retinopathy diabetes. ʻO ka hoʻomau hou ʻana o ka mālama glycemic i hōʻemi ʻia ka hopena o ka neuropathy a me ka retinopathy diabetic.
I ka wā o ka mālama ʻana, pono ke mālama ʻia i ka wā e komo ai i nā hana ʻehaʻeha (me ke kaʻa lele), kahi e koi ʻia ai ka nui o ke neʻe a me ka wikiwiki o ka hopena psychomotor, ʻoiai e ulu ʻia ana ka hypoglycemia, me ka mea nui i nā mea maʻi me nā kī pinepine a i ʻole a i ʻole (ʻoluʻolu) i nā hōʻailona mua.