Egipentin - ka wehewehe ʻana o ka lāʻau lapaʻau, nā kuhikuhi no ka hoʻohana, nā loiloi

Waiho i kāu manaʻo

Nā ʻIke Kūlana Kūlana, ‰

ʻO nā palapala hōʻoia EGIPENTIN

• LP-000879

• LP-000684

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ʻOi aku nā mea hoihoi aʻe

Iwai a aie ke dttla.

ʻAʻole ʻae ʻia ka hoʻohana ʻana i nā ʻoihana.

ʻO ka ʻike e hana no nā lāʻau lapaʻau.

ʻO ka wehewehe ʻana i ka hana pharmacological

ʻO ka lāʻau antiepileptic. Hoʻohālikelike ka hoʻolālā kemika me GABA, ka mea e hana ai i ka mea kikowaena uha i ka pūnaehana neʻe. Manaʻo ka ʻano o ka hana o ka gabapentin ʻokoʻa i nā ʻenehana anticonvulsants e hana ana ma o nā GABA synapses (e komo pū ana ʻo valproate, barbiturates, benzodiazepines, GABA inhibaminase inhibitors, GABA uptake inhibitors, GABA agonists a me GABA prodrugs). Ua hōʻike ʻia nā haʻawina vitro ua hōʻike ʻia ka gabapentin e ka neʻe ʻana o kahi kahua paʻa peptide hou i loko o nā kōpio maʻa o nā iole, me ka hippocampus a me cerebral cortex, ka mea e pili ana me ka hana anticonvulsant o ka gabapentin a me nā mea nona. ʻAʻohe mea paʻa i ka gabapentin e hoʻopaʻa pū ai i nā lāʻau lapaʻau maʻamau a me nā mea hoʻokae neurotransmitter ʻē aʻe i loko o ka lolo, me ka me GABAA-, GABAB-, benzodiazepine receptors, me NMDA receptors.

ʻO ka mea hope loa, ʻaʻole i hoʻokū ʻia ka hana o ka hana o ka gabapentin.

Lapaʻau lāʻau

ʻO ka lāʻau antiepileptic. Hoʻohālikelike ka hoʻolālā kemika me GABA, ka mea e hana ai i ka mea kikowaena uha i ka pūnaehana neʻe. Manaʻo ka ʻano o ka hana o ka gabapentin ʻokoʻa i nā ʻenehana anticonvulsants e hana ana ma o nā GABA synapses (e komo pū ana ʻo valproate, barbiturates, benzodiazepines, GABA inhibaminase inhibitors, GABA uptake inhibitors, GABA agonists a me GABA prodrugs). Ua hōʻike ʻia nā haʻawina vitro ua hōʻike ʻia ka gabapentin e ka neʻe ʻana o kahi kahua paʻa peptide hou i loko o nā kōpio maʻa o nā iole, me ka hippocampus a me cerebral cortex, ka mea e pili ana me ka hana anticonvulsant o ka gabapentin a me nā mea nona. ʻAʻohe mea paʻa i ka gabapentin e hoʻopaʻa pū ai i nā lāʻau lapaʻau maʻamau a me nā mea hoʻokae neurotransmitter ʻē aʻe i loko o ka lolo, me ka me GABAA-, GABAB-, benzodiazepine receptors, me NMDA receptors.

ʻO ka mea hope loa, ʻaʻole i hoʻokū ʻia ka hana o ka hana o ka gabapentin.

Lapaʻau lāʻau

Hoʻopili ʻia ʻo Gabapentin mai ka papa hana. Ma hope o ka nānāʻana i ka Cmax gabapentin i ka plasma e loaʻa ma hope o nā hola 2-3.ʻO ka bioavailability piha pololei e pili ana i 60%. ʻO ka loaʻa ʻana o ka manawa like me nā meaʻai (me nā poʻe me ka momona momona) ʻaʻole i pili i ka pharmacokinetics o gabapentin.

ʻAʻole paʻa ʻo Gabapentin i nā protein plasma a loaʻa iā ia kahi Vd o 57.7 L. I ka poʻe maʻi me ka epilepsy, ʻo ka ʻike ʻana o ka gabapentin i loko o ka wai cerebrospinal, ʻo 20% o nā puna Css e pili ana i ka hope o ka waʻa.

Hoʻokahi wale ʻia nā Gabapentin e nā keiki. ʻAʻohe mau hōʻailona o ka biotransformation o gabapentin i loko o ke kino kanaka. ʻAʻole ʻo Gabapentin e hoʻonāukiuki i nā oxidases i komo i ka hana metabolism. ʻO ka hoʻihoʻi ʻana me ka maikaʻi e wehewehe ʻia me ka hoʻohālike laina. ʻO T1 / 2 he kūʻokoʻa kūʻokoʻa a he a me awelika 5-7 hola.

Hoʻemi ʻia ka clearance Gabapentin i ka poʻe elemakule a i nā mea maʻi me ka hana renal impaired. Ka palena wikiwiki, ka plasma a me ka wehe o ke alakaʻi ʻana o ka gabapentin i hoʻohālikelike mau ia me ka hoʻomaʻemaʻe kuhi.

Hoʻokuʻu ʻia ʻo Gabapentin mai ka plasma e nā hemodialysis.

ʻO nā ʻili o ka gabapentin plasma i like me nā pākeke.

Hoʻohana i ka wā hāpai

Hiki paha i ka wā hāpai ʻoiai inā he hopena ʻo ka hopena o ka hopena ma mua o ka hopena i ka pūpū (ʻoiaʻiʻo a paʻa pono ka hoʻopaʻa ʻia ʻana o nā wahine hāpai.

ʻO ka māhele FDA o ka hana no ka pūpū ʻo C.

I ka manawa o ka mālama ʻana, pono e hoʻōla ka umauma (gabapentin i loko o ka umauma wai i ka wā e lawe ʻia ai.

Nā hopena hopena

Mai ka ʻaoʻao o ka pūnaehana nīkini, a me nā ʻōnaehana hoʻoneʻe peralheral: amnesia, ataxia, confing, conclinical coordination of movement, depression, dizziness, dysarthria, meningkat nerve irritability, nystagmus, drowsiness, impaired thinking, tremors, convulsions, amblyopia, diplopia, hyperkinesia, worsening nele i nā pōkole, paresthesia, hopohopo, hoʻonāukiuki, hana lima.

Mai ka pūnaehana ʻana: hoʻololi i ka mālama ʻana o ka niho, ka ʻeha, ka nui o ka makemake, ka malo maloʻo, ka luaʻi, ka luaʻi ʻana, ka lemulima, anorexia, gingivitis, ʻeha o ka ʻōpū, pancreatitis, nā loli i nā hana hana ate.

Mai ka pūnaehana hemopoietic: leukopenia, hoʻemi ʻia ka helu sela ke keʻokeʻo, thrombocytopenic purpura.

Mai ka papa hana hanu: rhinitis, pharyngitis, pūlapu, pneumonia.

Mai ka papa musculoskeletal: myalgia, arthralgia, he iwi iwi.

Mai ka pūnaehana cardiovascular: hypertension arterial, manifestations of vasodilation.

Mai ka pānaehana urinary: urinary tract infection, ka urinary incontinence.

Nā maʻi maʻi: erythema multiforme, maʻi ʻo Stevens-Johnson.

Nā hopena dermatological: maceration o ka ʻili, ka huehue, ke kau, ʻeha.

Nā mea hou: ʻeha hoʻi, luhi, edema peripheral, impotence, asthenia, malaise, ʻūhā o ka maka, ka loaʻa ʻana o ka momona, ka hōʻeha ʻana me ka maʻi ʻona, ka hopena o ka maʻi like ʻana, nā maʻi like fliptuation i ka glucose koko, ma nā keiki - maʻi viral, otitis media.

ʻLoe a me ke kākele

I loko, e pili ʻole i ka ʻahaʻaina.

Postherpetic neuralgia: ma ka lā 1 o ka mālama ʻana - 300 mg / lā hoʻokahi, ma ka lā 2 - 1600 mg / lā (i 2 mau puʻupuʻu i hoʻokaʻawale ʻia), ma ka lā 3 900 mg / lā (i 3 mau dālā i hoʻokaʻawale ʻia). Inā pono, e hōʻemi i ka ʻeha ma kahi hopena ma hope aʻe, hiki iā ʻoe ke hoʻonui iā ia i 1800 mg / lā (i nā puʻu 3 i māhele ʻia).

ʻO Epilepsy (ma kahi ala ʻokoʻa): no nā mea maʻi ma mua o 12 mau makahiki - 900-1800 mg / lā (i nā lā 3.) ʻO ka dosis mua he 300 mg 3 mau manawa i ka lā, inā pono, e hoʻonui i ka ʻai i ka 1800 mg / lā. ʻAʻole pono nā lā o kēlā me kēia lā e 3600 mg. ʻO nā keiki he 3-12 mau makahiki - ke kumu mua o 10-15 mg / kg / lā (i 3 mau dona), koho ʻia ka hopena kūpono e ka titration no 3 mau lā.

No nā keiki he 5 mau makahiki a ʻoi aku ka nui, ʻo ka hopena maʻa mau he 25-35 mg / kg / lā, no nā keiki he 3-4 makahiki - 40 mg / kg / lā (ma 3 mau puʻupu i hoʻokaʻawale ʻia).

Pono ka lōʻihi loa ma waena o nā pona ma mua o 12 mau hola.

ʻO ka hoʻopau ʻia ʻana o ka gabapentin a me / me ka hoʻohui ʻana o kekahi mau anticonvulsant i ka mālama ʻia e hana lohi ʻia ma kahi o ka hapa he 1 mau pule.

I nā mea maʻi (ma mua o 12 mau makahiki) me ka hana hope ʻole o ka pilikia (cleinine clearance emi ma lalo o 60 ml / min) a i ʻole nā ​​mea maʻi e loaʻa ana i ka mālama hemodialysis, hoʻemi ʻia ka paʻu. Me ka hoʻokaʻawale ʻana ma o ka liʻiliʻi he 60 ml / min - 900-3600 mg / lā, me ka hoʻomaʻemaʻe ʻana o 30-65 ml / min - 400-11400 mg / lā, 15-29 ml / min - 200-700 mg / lā, emi mai ka 15 ml / min - 100-300 mg / lā. No nā maʻi maʻi hemodialysis, ʻo ka nui hou ka pume ma hope o hemodialysis he 125-350 mg ma hope o kēlā me kēia he 4 mau hola hemodialysis.

ʻO ka pilina me nā lāʻau lapaʻau ʻē aʻe

ʻO kahi pilina olakino koʻikoʻi ma waena o gabapentin a me nā anticonvulsants (phenytoin, valproic acid, phenobarbital, carbamazepine), me ka hopena o ka waha e loaʻa ana i ka norethisterone a me / a me ethinyl estradiol, ʻaʻole i paʻa.

Hoʻopau nā antacids i ka bioavailability o gabapentin (i nā haʻawina i lawe ʻia me Maalox, ua hoʻemi ʻia ka bioavailability o gabapentin e 20%, i ka manawa i lawe ʻia 2 mau hola ma hope o ka lawe ʻana iā Maalox, ma ka 5%).

Hoʻemi iki ka Cimetidine i ka hoʻonuiʻana o ka gabapentin.

ʻO Naproxen (ma kahi o 250 mg o ka poki), ka mea, e hoʻonui ai i ka hoʻihoʻi ʻana o ka gabapentin (ma kahi ana o 125 mg) mai 12 a 15%. ʻAʻole pili ʻo Gabapentin i nā parekola pharmacokinetic o ka naproxen. ʻAʻole ʻike ʻia nā pilina pili nui o kēia mau lāʻau i nā dosis i makemake ʻia.

ʻO Morphine (60 mg) i ka wā i lawe ai i 2 mau hola ma hope o ka lawe ʻana i ka gabapentin (600 mg) hoʻonui i ka AUC o ka gabapentin e 44%.

Hoʻomaʻamaʻa no ka hoʻohana

ʻAʻole pono e kuhikuhi ʻo Gabapentin i nā poʻe maʻi ma lalo o ka 12 mau makahiki o ke kumu me ka hoʻohaʻahaʻa ʻia o ka hana renalona (ʻaʻohe mea i hoʻokō ʻia ʻia kahi hoʻokolokolo). Noi aku ke ʻano o ka ʻoi ʻana no ka poʻe ʻelemakule (pili i nā maʻi renal e pili ana i ka maʻi, ua hoʻonohonoho ʻia ke ʻano hoʻohālikelike me ka cleince creatinine).

ʻOiai e lawe ana i ka gabapentin, ʻaʻole pono ʻoe e lawe i nā kaʻa a hoʻohana i nā lako hana pono e pono ai ka nui o ka makaʻala.

Nā ʻōlelo kikoʻī kūikawā no ke komo ʻana

Ke hui pū ʻia me ka morphine, pono e kāohi i ka hopena o ka hopena mai nā kikowaena sentral. Hoʻēmi iki ʻia ka nui o ka gabapentin a me ka morphine.

ʻAʻole pono e lawe i ka Gabapentin ma mua o 2 mau hola ma hope o ka lawe antacid.

Ke hoʻoholo nei i ka protein i ka urine me ka hoʻohana ʻana i ka hōʻike ʻo Ames N-Multistix SG, hiki ke loaʻa ka hopena maikaʻi ʻole maikaʻi me ka hoʻohana pū ʻana o gabapentin me nā anticonvulsants ʻē aʻe, no laila ua ʻōlelo ʻia e hoʻohana i nā ʻano loiloi.

Nā hōʻailona no ka hoʻohana ʻana

ʻO ka hōʻeha ʻana o nā ʻeha neuropathic i nā pākeke ma luna o nā makahiki he 18, ka monotherapy o ka ʻalopiha ma ke ʻano me ka ʻole o ka kaupalena luaʻi i nā pākeke a me nā keiki ma mua o 12 o kona mau makahiki, he mea hana hou i ka mālama ʻana i nā kuʻuna o ka hapa ʻana a me ka ʻole o ka hoʻomohala lua ʻana i nā pākeke a me nā keiki 3 mau makahiki o ka makahiki. a me na makua.

Ka hana lāʻau lapaʻau

ʻO ka lāʻau antiepileptic. Hoʻohālikelike ka hoʻolālā kemika me GABA, ka mea e hana ai i ka mea kikowaena uha i ka pūnaehana neʻe. Manaʻo ka ʻano o ka hana o ka gabapentin ʻokoʻa i nā ʻenehana anticonvulsants e hana ana ma o nā GABA synapses (e komo pū ana ʻo valproate, barbiturates, benzodiazepines, GABA inhibaminase inhibitors, GABA uptake inhibitors, GABA agonists a me GABA prodrugs).

Inoa Kūʻai ʻole honua

INN Kaukaʻikaʻi - Gabapentin.

ʻO Egipentin (International name Gabapentin) kahi lāʻau lapaʻau i hoʻohana ʻia i ka mālamaʻana i ka epilepsy, i hele pū ʻia me nā mea pōkole koʻikoʻi.

I ka papa inoa o nā ATX honua, ua loaʻa ka lāʻau i ke code N03AX12.

E hoʻokuʻu i nā palapala a me ka ʻano

Loaʻa ka hopena lapaʻau i ka loaʻa ʻana o ka gabapentin i kēia lāʻau lapaʻau. Eia kekahi, ʻo ka hoʻonohonohoʻana o ka lāʻau e komo ai i ka povidone, poloxamer, crospovidone, magnesium stearate, hydrolase.

Loaʻa kēia lāʻau lapaʻau i ke ʻano o nā capsules, kēlā me kēia me ka liʻiliʻi loa 300 mg o ka mea hana ikaika. Hoʻopili ʻia nā pale i nā poli o nā 20 pcs. 3 a 6 mau blō i hiki ke hoʻopaʻa ʻia i kahi pahu kāwele.

Pehea e lawe ai i ka egipentin?

Kuhi ʻia ka lāʻau lapaʻau no ka mālama ʻana ma ka waha. Koho ʻia ka nui o ka paukē ʻia me ka mālama ʻana i ka nui o nā hōʻike no ka maʻi maʻi. I ka nui o nā hihia, ʻo kahi hapa kūpono o 300 a 600 mg i kēlā me kēia lā e lawa ai ka hoʻomaha ʻana i nā hōʻailona. Inā pono, hiki ke hoʻonui ʻia i ka 900 mg i kēlā me kēia lā.

Me ka mālama akahele nui, pono e hoʻohana ʻia kahi lāʻau lapaʻau inā he hoʻonui i ka hana epileptic ka hopena o ka hōʻeha o ka lolo traumatic.
Kuhi ʻia ka lāʻau lapaʻau no ka mālama ʻana ma ka waha.
ʻO ka mālamaʻana i nā mea maʻi me ka maʻi mellitus, ma nā hapa nui, ke lawe ʻia nei i nā koina.

Mai ka musculoskeletal a me ka hoʻopili pili

E hoʻohana paha ʻo Egipentin i ka hōʻeha ʻana. Ma nā hihia lohi, e kū'ē ana i ke kua o ka lawe ʻana i ka lāʻau lapaʻau, ʻike ʻia ka hiʻohiʻona o ka edema a me ka hoʻopaʻapaʻa o nā huina, tendonitis a me nā māla. Eia kekahi, hiki i kēia lāʻau lapaʻau ke hana i ka pono o ka wā e hiki ai ke bursitis, nā uaua a me ka osteoporosis.

ʻŌpala Gastrointestinal

ʻO nā microbiology Clinical o Egipentin e like me ka hana maʻamau o ka lāʻau lapaʻau, hana maoli ka hana maʻamau o ke ʻano o ka digestive. Hiki i kēia lāʻau lapaʻau ke hoʻoiho i ka stomatitis, gastroenteritis, glossitis, esophageal hernia, proctitis, etc. Hiki i ka lāʻau lapaʻau ke hoʻonāukiuki i ka hoʻonui ʻana o ke kahe ʻana o ka ʻōpala. Eia kekahi, loaʻa i nā mea maʻi ke hoʻopiʻi o ka ʻeha o ka ʻōpū.

Hematopoietic mau hui

Me ka hoʻohana ʻana o Egipentin, thrombocytopenia, hiki mai paha nā hōʻailona o ka anemia a me purpura.

E hoʻohana paha ʻo Egipentin i ka hōʻeha ʻana.
ʻO nā microbiology Clinical o Egipentin e like me ka hana maʻamau o ka lāʻau lapaʻau, hana maoli ka hana maʻamau o ke ʻano o ka digestive.
E kūlike i ka hope o ka hoʻohana o ka Egipentin, hiki mai paha ka hoʻouka ʻana i ka psychosis.

Pūnaehana pīhoihoi waena

Hiki i ka hoʻohana ʻana o Egipentin ke hoʻonāukiuki i ka hōʻemi o nā reflexes a me ka ʻike ʻole ʻana o kekahi mau ʻōpū o nā iwi. Eia kekahi, ʻo ka mea ikaika o ka lāʻau lapaʻau e hiki ai i ka hōʻeha ma ke ʻano o ke kikowaena, ka huhū intracranial a me ka cerebellar dysfunction. E kūʻē i ke ʻano o ka hoʻohana ʻana o Egipentin, kahi manaʻo o ka euphoria, nā hallucitions a me ka hoʻouka ʻana o ka psychosis. Hiki i ka hopena o ka ʻono, ke hiamoe ʻana i ke ao a me ka hoʻopili ʻana o nā lūlū.

Mai ka pūnaehana cardiovascular

ʻO ka hoʻomohala ʻana o nā hopena ʻaoʻao mai ka lawe ʻana iā Egipentin mai ka ʻōnaehana cardiovascular loa i kahi ʻemi ʻia ka lōʻihi. I ka manawa like, aia kahi pilikia o ka arrhythmia, vasodilation a lele i ka pehu koko.

ʻO ka lawe ʻana iā Egipentin hiki i ka cystitis a me ka mālama ʻana o ka urinary.
Eia kekahi, hiki i ka lāʻau lapaʻau ke hoʻonāuki i ka hoʻomohala ʻana o ka hiki ʻole o ka hana renal.
E kūlike i ke ʻano o kēia lawe ʻana i kēia lāʻau lapaʻau, ka hiʻohiʻona o nā hopena kūlohelohe, i hōʻike ʻia e like me ka ʻōmaka kino.

E pale aku i ke ʻano o ka lawe ʻana i kēia lāʻau lapaʻau, hiki mai nā hopena alia, i ʻōlelo ʻia me ka ʻūʻā a me ke ʻāʻī, ke puhi ʻana o nā ʻalū palupalu. I nā hihia pinepine, ʻike ʻia nā hopena anaphylactic.

Hoʻohana i ka wā hāpai a me ka lactation

ʻAʻole maikaʻi ʻia ka maikaʻi a me ka palekana o ka hoʻohana ʻana i ka lāʻau lapaʻau i ka wā hāpai a me ka lactation, no laila, ʻaʻole i ʻike ʻia kēia mau ʻano, he contraindication no ka hoʻohana ʻana o Egipentin.

ʻAʻole ʻōpiopio ke ʻano ʻōpiopio no ka hoʻohana ʻana i nā lāʻau lapaʻau, akā koi ʻia ka hoʻoponopono ʻana iā ʻoe ma muli o ka hana o nā kuhi.
Hiki ke hoʻohana ʻia ka lāʻau lapaʻau i ka mālama ʻana i ka epilepsy i loko o nā keiki ma mua o 12 mau makahiki.
ʻO nā wā hāpai a me ka lactation he contraindication no ka hoʻohana ʻana iā Egyptina.
Inā lawe nui ʻoe i Egipentin, hele pinepine ka maʻi maʻamau.
Hiki i ka Egipentin ke hoʻonui i ka kahe o ka phenytoin i loko o ke kō koko a ʻo ia e hoʻohana ai.

Hoʻolaha ka waipuna

Ke mālama ʻia nei me kēia lāʻau lapaʻau, ʻaʻole pono e lawe ʻia ka waiʻona.

ʻO nā lāʻau lapaʻau e loaʻa ai kahi hopena like me ka hopena:

1. Neurontin.
2. Tebantin.
3. Gabagamma
4. Convalis.
5. Gabapentin.
6. Katena.
7. Gapantek et al.

Gabapentin Tablet. Epilepia ʻO ka ea o ka lā Malaki 16, 2016. Hōʻike HD.

Mea hana

ʻO ka lāʻau lapaʻau i hana ʻia e Iberfar-Industry Pharmaceutical.

ʻO ka hui like ʻo Neurontin.
ʻO kahi koho aʻe, hiki iā ʻoe ke koho iā Tebantin.
Inā pono, hiki ke loli i ka lāʻau lapaʻau me Convalis.

Nā ʻike e pili ana iā Egipentin

Svetlana, 32 makahiki, Eagle

Ua hoʻopilikia ʻia wau ma ka epilepsy mai ka wā ʻuʻuku. Hoʻomaʻama pinepine ʻia nā hana hoʻoiho ma hope, akā, ʻohi ke kauka i nā lāʻau lapaʻau a kū lākou. Ma kahi o 3 mau makahiki i hala aku nei, ua hāpai ʻo ia a nalowale ke pēpē. E kūʻē hou i kēia ʻāina, ua hoʻomaka hou nā hana ʻino. Ua kuhikuhi ʻo ke kauka iā Egipentin. Ua hoʻohana i ka lāʻau lapaʻau no 6 mau mahina. Ua hauʻoli wau i ka hopena. ʻAʻole au i nānā i nā hopena pili, akā e lūlū i ka helu o ka hōʻemi ʻana. ʻOiai ʻo ka manaʻo o ka hoʻokipa ʻana i nā kālā, i hoʻokahi makahiki, ʻaʻohe ahiki.

Grigory, 26 makahiki, Vladivostok

Ua hoʻāʻo wau i nā lāʻau lapaʻau he nui e hoʻopau i ka ʻōkuhi epileptic. Hoʻohana ʻia ka Egyptin e kekahi kauka. ʻAʻole kūpono kēia lāʻau lapaʻau noʻu. Mai ka lā mua o ka hoʻokele ʻana, puka mai nā hopena o ke ala mai ka gastrointestinal tract. ʻO ka ʻehaʻeha o ka puʻuwai, luaʻi a me ke kanikau ua hoʻopau iaʻu i ka lawe ʻana i ka lāʻau.

Loaʻa ka hopena

Mai ka ʻaoʻao o ka pūnaehana nīkini, a me nā ʻōnaehana hoʻoneʻe peralheral: amnesia, ataxia, confing, conclinical coordination of movement, depression, dizziness, dysarthria, meningkat nerve irritability, nystagmus, drowsiness, impaired thinking, tremors, convulsions, amblyopia, diplopia, hyperkinesia, worsening nele i nā pōkole, paresthesia, hopohopo, hoʻonāukiuki, hana lima.

Mai ka pūnaehana ʻana: hoʻololi i ka mālama ʻana o ka niho, ka ʻeha, ka nui o ka makemake, ka malo maloʻo, ka luaʻi, ka luaʻi ʻana, ka lemulima, anorexia, gingivitis, ʻeha o ka ʻōpū, pancreatitis, nā loli i nā hana hana ate.

Mai ka pūnaehana hemopoietic: leukopenia, hoʻemi ʻia ka helu sela ke keʻokeʻo, thrombocytopenic purpura.

Mai ka papa hana hanu: rhinitis, pharyngitis, pūlapu, pneumonia.

Mai ka papa musculoskeletal: myalgia, arthralgia, he iwi iwi.

Mai ka pūnaehana cardiovascular: hypertension arterial, manifestations of vasodilation.

Mai ka pānaehana urinary: urinary tract infection, ka urinary incontinence.

Nā maʻi maʻi: erythema multiforme, maʻi ʻo Stevens-Johnson.

Nā hopena dermatological: maceration o ka ʻili, ka huehue, ke kau, ʻeha.

Nā mea hou: ʻeha hoʻi, luhi, edema peripheral, impotence, asthenia, malaise, ʻūhā o ka maka, ka loaʻa ʻana o ka momona, ka hōʻeha ʻana me ka maʻi ʻona, ka hopena o ka maʻi like ʻana, nā maʻi like fliptuation i ka glucose koko, ma nā keiki - maʻi viral, otitis media.

ʻŌpū a me ka lactation

ʻAʻohe kūpono i hoʻopaʻa ʻia ʻana nā haʻawina e pili ana i ka palekana o ka gabapentin i ka wā hāpai a me ka lactation i ke kanaka. Inā pono, e hoʻohana pono i ka wā hāpai a me ka lactation e noʻonoʻo pono i nā pōmaikaʻi e kali ʻia ana no ka maʻi no ka makuahine a me ka pilikia o ke kīpē a i ʻole keiki.

Hoʻokā ʻia ʻo Gabapentin i loko o ka waiū umauma. Ke hoʻohana ʻia i ka wā o ka lactation, ʻaʻole i hoʻokumu i ke ʻano o ka hana o ka gabapentin ma ka pēpē.

Hoʻohui

I ka manawa e hui pū ai me nā anticonvulsants ʻē aʻe, ua hōʻike ʻia ka hopena o ka hōʻike hoʻoliʻi hoʻoliʻi-urine. I mea e hoʻoholo ai i ka protein i ka urine, ua ʻoi ʻia e hoʻohana i kahi ʻano ʻoi aku ai o ka ua o ka peka o ka waila o ka waila.

Me ka hoʻohana like ʻana me nā antacids, ʻo ka hoʻohemo ʻana o ka gabapentin mai ka gastrointestinal tract e emi.

Me ka hoʻohana like ʻana me ka felbamate, hiki ke hoʻonui ʻia ma T1 / 2 o ka felbamate.

Me ka hoʻohana like ʻana, kahi hihia o ka hoʻonui ʻana i ka phenytoin i loko o ke koko koko ua hōʻike ʻia.

Hoʻohana i nā keiki

ʻO kēia ka hopena a me ka palekana o ka hopena no ka maʻi neuropathic i nā mea maʻi ma lalo o nā makahiki 18 a ʻaʻole i hoʻokumu.

ʻO ka hana pono a me ka palekana o ka monotherapy gabapentin i ka mālama ʻana i nā mālamakiki o nā hapa i nā keiki ma lalo o 12 mau makahiki he nui a me ka lāʻau hou me ka gabapentin i ka mālama ʻia ʻana o nā mea pōkole i nā keiki ma lalo o 3 mau makahiki ʻaʻole i hoʻokumu.