ʻO ka lāʻau Lozap Plus

Inoa inoa honua - Hoʻohui ʻia ʻo Lozap

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

Nā papa hana ʻulaʻī kukui aniani, oblong, me ka laina hoʻokaʻawale ma ka ʻaoʻao ma nā ʻaoʻao ʻelua. I 1 kōpō mau ka: losartan potassium - 50 mg, hydrochlorothiazide - 12.5 mg.

Nā mea kūʻai: mannitol - 89 mg, cellulose microcrystalline - 210 mg, sodium croscarmellose - 18 mg, povidone - 7 mg, magnesium stearate - 8 mg, hypromellose 2910/5 - 6.5 mg, macrogol 6000 - 0.8 mg, talcum powder - 1.9 mg, simethicone emulsion - 0.3 mg, dye Opaspray yellow M-1-22801 - 0,5 mg (wai i hoʻomaʻemaʻe ʻia, titanium dioxide, ethanol denatured (methylated alika BP: ethanol 99% a me ka methanol 1%), hypromellose, kuana Quinolin Kunani (E104), kuʻu Pounceau 4R (E124).

Hoʻokuʻu palapala: 10 kamepiula - blisters (1, 3 a 9 paha pcs.) a i ʻole 14 pcs. - nā kāmele (2) - nā kīʻaha o ke kāleka.

Nā ʻoihana ʻoihana ʻo ka ʻoihana kāohi me ka lāʻau lapaʻau

ʻĀpana Pharmacotherapeutic

Hoʻopili hui antihypertensive (angiotensin II mea hoʻokele blocker + diuretic)

Ka hana lāʻau lapaʻau

ʻO ka lāʻau antihypertensive. Pahuau (intertype AT 1) i hoʻokahi angiotensin II receptor antagonist. ʻAʻole ia i pale i ka kininase II, kahi enzyme e hōʻiliʻili nei i ka hoʻololi ʻana o ka angiotensin I ka angiotensin II. Hoʻemi i ka OPSS, pae koko o ka adrenaline a me aldosterone, kahe koko, ke kaomi ana i ke kaila pulmonary, e hōʻemi ana ma hope o ka luʻu, he hopena diuretic. Kūleʻa ʻia me ka hoʻomohala ʻana o ka hypertrophy myocardial, hoʻonui i ka hoʻolahalaha ʻana i nā maʻi me nā maʻi ʻoi ʻole ka maʻi. ʻAʻole ʻo Lasartan e kālai i ka ACE kininase II a, no laila, ʻaʻole i pale i ka luku ʻana i ka bradykinin, no laila, ʻaʻole like ka hopena o nā ʻaoʻao i ka pili me bradykinin (no ka laʻana ka angioedema) he mea maʻamau ka maʻamau.

I nā mea maʻi me ka hypertension arterial me ka hapa ʻole o ka maʻi diabetes me ka proteinuria (ʻoi aku ma mua o 2 g / lā), ka nui o ka hoʻohana ʻana i ka lāʻau lapaʻau he nui ka proteinuria, ka hoʻopuka ʻana o nā albumin a me ka immunoglobulins G.

Mālama i ka pae o ka urea i ka plasma koko. ʻAʻole pili i ka pōkole vegetative a ʻaʻohe i ka hopena lōʻihi i ka neʻe ʻana o ka norepinephrine i ka plasma koko. ʻO Losartan i kahi aniani a hiki i ka 150 mg / lā ʻaʻole i hoʻopilikia i ka pae o ka triglycerides, ka nui o ka kolamu a me nā kolamu HDL i ka serum o ke koko i nā mea maʻi me ka hypertension arterial. Ma ka hopena like, ʻaʻole pili ʻo losartan i ka wikiwiki o ka glucose koko.

Ma hope o ka lawelawe waha hoʻokahi, ua emi ka hopena hypotensive (systolic a me ka diastolic blood pressure) a hiki i ka nui loa ma hope o 6 mau hola, a laila hoʻemi iki ʻia ma loko o 24 mau hola.

Hoʻopilikia ka hopena hypotensive kiʻekiʻe ma 3-6 mau pule ma hope o ka hoʻomaka ʻana o ka lāʻau lapaʻau.

Lapaʻau lāʻau

I ka nānā ʻana, ua hoʻokomo maikaʻi ʻia ka losartan, a ua hoʻomōhola ʻia ia i ka metabolism i ka wā o ka "hele mua" ma o ka palaka ma ka carboxylation me ka komo ʻana o ka isoenzyme cytochrome CYP2C9 me ka hoʻokumu o ka metabolite ikaika. ʻO ka bioavailability o ka'ōnaehana o losartan e pili ana i 33%. Loaʻa ka pae kiʻekiʻe o losartan a me kāna neʻe ʻano hana i loko o ka serum koko ma hope o kahi o 1 hola a 3-4 mau hola ma hope o ka hana ʻana, kēlā. ʻO ka ʻai ʻaʻole e pili i ka bioavailability o losartan.

ʻOi aku ma mua o ka 99% o losartan a me kāna metabolite hoʻoikaika e nakinaki ai i nā protein plasma, ʻoi loa me ka albumin. V d losartan - 34 l. ʻAʻole ʻaʻole ʻo Losartan e komo i ka BBB.

Ma kahi o 14% o losartan i hāʻawi ʻia i loko o kahi metabolite ikaika.

ʻO ka wehe i ka plasma o ka losartan o 600 ml / min, a me ka metabolite ikaika e 50 ml / min. ʻO ka hoʻomaʻamaʻa kino ʻole o ka losartan a me kāna metabolite kaola i ka 74 ml / min a me 26 ml / min, kēlā. Ke hōʻike ʻia, ma kahi o 4% o ka nui i lawe ʻia e excreted e nā keiki i loli ʻole a ma kahi o 6% e hoʻopiʻi ʻia e nā keiki ma ke ʻano o kahi metabolite hoʻoikaika. Hōʻike ʻia ʻo Losartan a me kāna metabolite hoʻoikaika e ka linear pharmacokinetics i ka wā i lawelawe ʻia ai i nā waha ma nā dosis a hiki i ka 200 mg.

Ma hope o ka lawelawe waha, ua hōʻiliʻili ka plasma i ka losartan a me kāna neʻe ʻana i ka hoʻoneʻe metabolite me ka hapalua hapalua o ka losartan ma kahi o 2 mau hola, a me ka metabolite ikaika e pili ana i nā hola 6-9. Ke lawe nei i ka lāʻau lapaʻau ma kahi o nā 100 mg / lā, ʻaʻole ka losartan a me ka metabolite ikaika e hōʻiliʻili nui i loko. pili koko. Hoʻokumu ʻia ʻo Losartan a me kāna mau metabolites ma o ka ʻōpū a me nā ʻili. I nā mea olakino olakino, ma hope o ka nānā ʻana i ka losartan i hoʻopaʻa ʻia me 14 C-isotope, kahi o 35% o ka hōʻailona radioactive i loaʻa i loko o ka urine a ʻo 58% i nā feces.

ʻO ka pharmacokinetics i nā hihia lapaʻau kūikawā

I ka poʻe maʻi me ka cirrhosis waiʻona maʻalahi, ʻo ka 5 ʻana o ka lilo ʻana o losartan, ʻo 5 mau manawa, a ʻo ka metabolite ikaika e 1,7 mau manawa ma mua o nā mea hana manawaleʻa kāne maikaʻi.

Me CC> 10 ml / min, ʻo ka neʻe ʻana o ka losartan i loko o ke kaila koko he ʻokoʻa ʻole ia i kēlā me kēia hana maʻamau. I nā poʻe maʻi e pono ai i ka hemodialysis, ʻo AUC ma kahi kokoke i 2 mau manawa ke kiʻekiʻe ma mua o nā mea maʻi me ka hana maʻamau maʻamau.

ʻAʻole ʻo ka losartan a me kāna metabolite kūlohelohe i wehe ʻia i ke kino e ka hemodialysis.

ʻO ka nānā ʻana o losartan a me kāna metabolite hoʻoikaika i ka plasma koko i nā kāne ʻelemakule me ka hypertension arterial ʻaʻole ʻokoʻa loa nā kumu o kēia mau ʻiliʻili i nā ʻōpio a me ka hypertension arterial.

ʻO nā mea pili i ka plasma o losartan i loko o nā wahine me ka hypertension arterial he 2 mau manawa kiʻekiʻe ma mua o nā helu i pili i nā kāne me ka hypertension arterial. ʻOkoʻa nā ʻoliʻoli o ka metabolite ikaika i nā kāne a me nā wahine. ʻAʻole koʻikoʻi kēlā kapa lapaʻau pharmacokinetic.

• hypertension arterial (ma ke ʻano o ka hoʻohui ʻana i nā lāʻau lapaʻau no ka mea nona ka ʻano o kēia ʻano maʻi)
• hōʻemi iki i ka hoʻomohala ʻana i ka maʻi cardiovascular a me ka make ma ka poʻe maʻi me ka hypertension arterial a waiho aku i ka ventricular hypertrophy.

Nā Hoʻohui

• hypokalemia-pale or hypercalcemia,
• lima hana hoʻopili hewa,
• pilikia maʻi o ka biliary tract,
• hiponatremia mare,
• ka hyperuricemia a me / a me ka momona
• hana hōʻeha koʻikoʻi (CC ≤ 30 ml / min),
• anuria
• hapai
• umauma umauma,
• a hiki i 18 makahiki (ʻaʻole i hoʻokumu ʻia ka pono a me ka palekana),
• hypersensitivity o kekahi o nā mea o ka lāʻau a i ʻole nā ​​lāʻau lapaʻau ʻē aʻe nā mea e hua mai o ka sulfonylamide.

Me ka akahele i kuhikuhi ʻia i nā mea maʻi me ka stenosis aroteal renalal stenosis a i ʻole ka stenosis o hoʻokahi artery kidney, ke ʻano hypovolemic (me ka nānā ʻana i ka maʻi, ka luaʻi), hyponatremia (hoʻonui nui aʻe o ka hypotension arterial i nā mea maʻi ma ka paʻakai liʻiliʻi a i ʻole ka paʻakai paʻakai), hypochloremic alkalosis, hypomagnesemia, me ka nā maʻi ʻili lohi (me ka SLE), nā mea maʻi me ka hana aho ʻole a i ʻole ke ahonui ʻana o nā maʻi ʻōmaʻomaʻo, diabetes mellitus, bronchial asthma (me ka mōʻaukala), he mea kaumaha kaumaha cal mōʻaukala, ka poʻe me NSAIDs, me COX-2 inhibitors, loaʻa nā ʻelele o ka lāhui Negroid.

Dodage regimen a me ke ʻano o ka noi ʻO Lozapa Plus

Lawe ʻia ka lāʻau lapaʻau ma ke ʻano, me ke ʻano o ka ʻaina.

I haehae maʻi ka papa mua a me ka mālama mālama ʻia 1 papa / lā. Inā hoʻohana ʻoe i ka lāʻau i loko o kēia hopena, ʻaʻole hiki ke hoʻokō kūpono i ka kaohi o ke koko, hiki ke hoʻonui ʻia i ka nui o ka lāʻau Lozap Plus i nā papa ʻelua. 1 mau lā / lā

ʻO ka nui loa he 2 papa. 1 mau lā / lā Ma keʻano holoʻokoʻa, ua loaʻa ka hopena hypotensive nui i loko o 3 mau pule ma hope o ka hoʻomaka ʻana o ka mālama ʻana.

ʻAʻohe mea pono no ke koho kūikawā o ka inea mua no nā maʻi maʻi maʻi.

Me ka e hōʻemi i ka hopena o ka hoʻomohala ʻana i ka maʻi cardiovascular a me ka make ma ka poʻe maʻi me ka hypertension arterial a waiho aku i ka ventricular hypertrophy Ua kau ʻia ka losartan (Lozap) i kahi paona mua o 50 mg / lā. ʻO nā mea maʻi i hōʻole ʻole i ka pae o ke koʻina o ke koko aʻo ka hoʻohana ʻana i ka losartan ma kahi maʻa o 50 mg / lā e noi ana i ka mālama ʻana me ka hui pū ʻana o losartan a me hydrochlorothiazide ma kahi haʻahaʻa haʻahaʻa (12.5 mg), ka mea i hōʻoia ʻia e ke koho ʻana i ka lāʻau Lozap Plus. Inā pono, hiki ke hoʻonui ʻia i kēiaʻano o ka Lozap Plus i nā papa ʻelua. (100 mg o losartan a me 25 mg o ka hydrochlorothiazide) 1 manawa / lā.

Loaʻa ka hopena ʻO Lozapa Plus

Hōʻalo ʻia nā hopena ʻino e like me ka neʻe ʻana o ka hoʻomohala e like me kēia: mau pinepine (≥ 1/10), pinepine pinepine (≥ 1/100 a i ʻole

No ke aha ke hoʻokō ʻia ai ka loiloi EMIS?

ʻO Galurized pleurisy o nā māmā a me ka mālama ʻana - heluhelu i ka ʻike a pau e pili ana i ka maʻi kanesa ma ka pūnaewele o ka European Clinic.

E hoʻokuʻu i ke ʻano a me ka ʻano

Loaʻa ka Lozap Plus i ke ʻano o nā papa kiʻi ʻoniʻoni: oblong, me ka pākē ma nā ʻaoʻao ʻelua, kukui aniani (10 mau p. In blisters, in a cardbows of 1, 3 or 9 blisters, 14 pcs. kahi pā o 2 blisters).

Kāleka i kēlā me kēia 1 papa:

• mau mea hana: hydrochlorothiazide - 12.5 mg, losartan potassium - 50 mg,
• ʻO nā māhele kōkua: microcrystalline cellulose, povidone, mannitol, magnesium stearate, sodium croscarmellose,
• uhiʻa kiʻi: macrogol 6000, emulsion simethicone, crimson dye Ponso 4R, hypromellose 2910/5, talc, titanium dioxide, quinoline ʻeleele melemele.

Lapaʻau lāʻau

ʻO Lozap plus kahi hui lāʻau hoʻohui e loaʻa ana i kahi hopena hypotensive. He pāhule ʻāpana na kaiotensin II, a ʻo ka hydrochlorothiazide, he diuretic thiazide.

Hōʻike nā mea ikaika o ka lāʻau i ka hopena synergistic, hoʻohaʻahaʻa i ke koko i ka hui ʻana i ka nui ʻoi aku ma mua o ke kanaka hoʻokahi.

ʻO ka haʻahaʻa o ka Losartan e hoʻohaʻahaʻa i ka OPSS (ka nui o ka paleʻana i ka vascular peripheral), e hōʻemi ana i ka luhi o ka ald testosterone a me adrenaline i loko o ke koko, e hōʻemi ana i ka pehu i ka laha pulmonary, e hoʻopuka ai i kahi hopena diuretic a hōʻemi ma hope o ka ukana. I nā mea maʻi me ka puʻuwai puʻuwai hema, hoʻonui ʻo losartan i ka pale ʻana i ka hoʻoikaika kino, pale i ka hiki ʻana o ka hypertrophy o ka puʻuwai naʻau.

Hoʻonui ka Hydrochlorothiazide i ka hoʻonuiʻana o nā phosphates urine, bicarbonate a me nā paʻakai potassium, e hoʻoneʻe ana i ka reabsorption o ka paʻakai sodium. ʻO ka hoʻohaʻahaʻa i ke koko ka mea e hiki ai ke hoʻololi i ka reaktivity o ka paia vascular, e hōʻemi ana i ka nui o ke kahe koko, e hoʻonui ana i ka hopena kaumaha ma ka ganglia a me ka hōʻemi ʻana i ka hopena pressor o nā mea vasoconstrictor.

Ka hopena antihypertensive o Lozap a i hoʻomau i 24 mau hola. ʻAʻole loaʻa ka hopena nui o ka lawe ʻana i nā paila i ka puʻuwai aloha. ʻO ka lāʻau lapaʻau e hōʻemi pono i ke kahe o ke koko i nā kāne a me nā wahine, i nā mea maʻi a me nā ʻōpio, nā mea maʻi me Negroid a me nā lāhui ʻē aʻe, a me kekahi ʻano o ka hōʻeha o ka hypertension arterial.

Lapaʻau lāʻau

Hoʻopili koke ʻia ʻo Losartan mai ka huehue wai ʻana. ʻO kona bioavailability e pili ana i ka 33% ma muli o ka hopena o ka pau mua ma o ke ake. Hoʻomoe ka metabolism ma ka carboxylation, ka hopena i ka hoʻokumu ʻana o ka metabolite hoʻoikaika - carboxylic acid. Hoʻopili nā 99% losartan i nā protein plasma. Loaʻa ka lōʻihi o kona kaila i ka plasma ma hope o ka hola 1, a me ka makaʻala o ka metabolite ikaika ma hope o nā hola 3-4. ʻAʻole pili ka ʻai i ka ʻai i ka plasma o ka losartan. ʻO ka nui o ka hoʻoilina he 34 lita. ʻAʻole komo ʻo Losartan i ka pale koko-lolo. ʻO ka hapalua o ka ola o ka losartan he 1.5-2 mau hola, ʻo ka carboxylic acid he 3-4 mau hola. Ma kahi o 35% o ka nui i loaʻa i ka excreted i loko o ka urine a ma kahi o 60% o nā feces.

ʻO ka holo ʻana o ka hydrochlorothiazide ka wikiwiki, ʻaʻole i wae ʻia e ka ʻalopona. ʻAʻole hele ʻo Hydrochlorothiazide i ka pale koko-lolo a ʻaʻole i hūnā ʻia e ka waiū umauma, akā ua komo i ka pāʻai placental. ʻO ka hapalua hapa-ola ʻo 5.8-14.8 mau hola. Ma kahi o 61% o hydrochlorothiazide e unuhi ʻia e hoʻololi ʻia e nā keiki.

ʻAʻole maikaʻi loa nā hōʻailona o ka pharmacokinetic o Lozap i nā poʻe maʻi maʻi i nā mea maʻi ʻōpio.

Me ka cirrhosis hoʻohaʻahaʻa a hōʻemi haʻalulu, nā kaila plasma o ka losartan a me kāna metabolite hoʻoikaika ʻia he 5 a me 1,7 mau manawa kiʻekiʻe, ʻoi aku ka nui ma mua o nā mea hana olakino. ʻAʻole maikaʻi kēlā Hemodialysis.

Nā Hoʻohui

• lima hana hoʻopili hewa,
• hana hoʻopololei paʻa kino (ʻo ka hoʻopihapiha hana hōʻemi ma mua o 30 ml / min),
• maʻiʻo cholestatic
• maʻi maʻi obstruktitis maʻi o ka biliary tract,
• ka nele o ka urine i loko o ka pākahi (anuria),
• hypercalcemia a hypokalemia (kūpaʻa i ka mālama ʻana),
• gout a / a hōʻailona paha hyperuricemia,
• hiponatremia mare,
• hapai a me lactation,
• na keiki a me na opio malalo o na makahiki he 18
• ka pilina me ka aliskiren i nā mea maʻi me ka hiki ʻole o ka hana (hana i hana ʻia ma lalo o 60 ml / min) a me ka maʻi mellitus.
• hypersensitivity i nā ʻāpana nui a kōkua paha i ka lāʻau.

Hoʻohana ʻia (Lozap plus me ka akahele):

• hypovolemia (e komo pū ana a i ʻole ka maʻi paha),
• hypomagnesemia, hyponatremia, hypochloremic alkalosis, hypokalemia,
• hyperkalemia
• maʻi maʻi coronary
• u me ka pohō nui o ka naʻau,
• puʻuwai puʻuwai, i ukali ʻia e ka pilikia nui ʻole,
• puʻuwai paʻakikī me nā arrhythmias weliweli ola,
• stenosis mitral a aicic,
• hypventrophic pono e hoʻonani,
• lawelawe aho ʻaia,
• maʻi maʻi ʻōnaehana,
• bilateral a i ʻole unilateral (ma ke ʻano o kahi keiki hoʻokahi) stenosis aralinal ke ake nei,
• kaukaʻi ma hope o kahi lihil ʻana,
• Hoʻokomo pūnana bronchial (me ka mōʻaukala),
• nā maʻi hui maʻi
• hyperaldosteron's,
• kekahi moolelo o ka makema Quincke,
• kaumaha history history
• maʻi maʻi cerebrovascular,
• hana ʻino e pili ana i ka koki puka-kikina glaucoma a me myopia,
• hoʻohana like me nā huahana anti-inflammatory non-steroidal,
• no ka lāhui Negroid,
• makahiki ma luna o ko 75 mau makahiki.

Hoʻokomo pū ʻia ʻo Lozap, nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana (nā ʻano a me ke ʻano)

Lawe ʻia ka papa ʻili pū me Lozap, e pili ʻole i ka ʻahaʻaina.

I nā maʻi me ka haehae maʻi, ua ʻōlelo ʻia ka lāʻau lapaʻau i kahi hana mua a me ka mālama ʻana o 1 papa i ka lā. Inā ʻaʻole lawa nā dosage i kuhikuhi pono e hoʻemi i ke koko, hiki nō ke hoʻonui i ke kau i ka papa 2 i hoʻokahi lā i ka lā.

ʻO ka nui loa o kēlā me kēia lā o ka lāʻau lapaʻau, he 2 papa, a hiki ke hopena ka hopena hypotensive kiʻekiʻe i loko o 3 mau pule ma hope o ka hoʻomaka ʻana o ka hopena.

No nā poʻe maʻi maʻi, ʻo Lozap plus i kuhikuhi ʻia i ka pākaukau maʻamau.

No ka hōʻemi ʻana i ka hopena o ka maʻi cardiovascular a me ka make ma, ka mua o ka dosis o losartan e 50 mg hoʻokahi i ka lā (1 papa o Lozap). Inā maikaʻi ʻole ka mālama ʻana, pono e koho i ka lāʻau maʻi ma ka hoʻohui ʻana i ka losartan me nā dosis liʻiliʻi o ka hydrochlorothiazide (1 papa o ka lāʻau Lozap + 1 papa o ka lāʻau Lozap a me ka lā). I ka wā e hiki mai ana, he mea hiki ke hoʻonui i ka maʻi i nā papa ʻelua o ka lāʻau Lozap a hoʻokahi hoʻi i ka lā.

Nā hopena hopena

ʻO nā hopena ʻaoʻao o ka lāʻau ma muli o ka hui pūʻana o losartan + hydrochlorothiazide:

• akeʻa a me ka tractary tract: jarang - hepatitis,
• cardiovascular system: frequency ʻike ʻole - hopena orthostatic (dosis hilinaʻi),
• ʻūnaehana nenoai: pilikia - hoʻāhu, ʻike ʻole - ʻike ʻole i ka ʻike
• ʻili a me ka ʻōpala ʻōpala: frequency frequency - systemic lupus erythematosus (skin form),
• nā noiʻi noiʻi a me nā mea hana: luhi - i hoʻonui ʻia i ka hana o nā enzymes ati, hyperkalemia.

Nā hopena hopena o ka lāʻau Lozap hoʻohui, ma muli o ka loaʻa o ka losartan i loko o kāna hoʻopili ʻana:

• gastrointestinal tract, ate a me nā kiko biliary pinepine: pinepine - nausea, dyspeptic disorders, ʻeha ʻeha, pale ʻōpala, maʻamau - kīpē maloʻo, luaʻi, ʻeha ʻōpio, gastritis, constipation, flatulence, freku ʻole ʻike - hemahema hana functioning,
• system cardiovascular: pinepine - - hypotension orthostatic, angina pectoris, myocardial infarction, arrhythmias, hoʻemi ʻia ke koko, ʻeha i ka sternum, vasculitis, atrioventricular block II degere, palpitations,
• lymphatic ʻōnaehana a me ke koko: pinepine - - hemorrhages i loko o ka ʻili a i ʻole nā ​​membrane mucous, anemia, erythrocytosis, maʻi Shenlein-Genoch, ʻike pinepine ʻole - thrombocytopenia,
• ka ʻōpū o ka ʻōpū: pinepine - ka huhū o ka ihu, ka ʻōpala, ka sinusitis, nā maʻi ʻeha o ka ʻaoʻao mākaukau, pinepine - laryngitis, bronchitis, rhinitis, pharyngitis, dyspnea, nosebleeds,
• nā aʻa a me ka psyche: pinepine - dizziness, insomnia, headache, infrequently - hopohopo, hiamoe pōʻino, huhū, hopohopo, moeʻuhane kūwaho, weliweli, panic attack, ʻehaʻeha, ke hiamoe nei, paresthesia, migraine, hoʻōlio hoʻomanaʻo ʻana, peripheral neuropathy, nāwaliwali.
• nā hui kuʻuna: pinepine - conjunctivitis, blurred vision, hōʻemi i ka ʻike acuity, hoʻomaʻamaʻa ʻana i ke ahi ma nā maka, kani ʻana i nā pepeiao, vertigo,
• ka ʻōnaehana musculoskeletal: pinepine - ʻeha i nā wāwae a me ke kua, sciatica, nā māka ʻana o ka hoʻo, ka pinepine - ʻeha i ka iwi a me nā ʻōpū, ka ʻili o ka naʻau, nāwīwī o ka ʻōpū, ka huehue o nā pūlima, arthralgia, fibromyalgia, ka hoʻopaʻowaha o nā ʻōpū, ʻike ʻole ka ʻike - myoglobinuria me ka hōʻoki kino ʻana,
• ʻōnaehana urinary: pinepine - renal failed, impalired renal function, pinepine - maʻamau urinary tract infection, urination pinepine, prevalence of nighttime diuresis over day,
• ʻōnaehana ʻōnaehana: pinepine - kani erectile dysfunction, hoʻemi i ka libido,
• ʻili a me ka ʻōpio ʻōpala: pinepine - dermatitis, erythema, photosensitivity, hōʻeha ʻili, ʻili nā lau, ʻili maloʻo, ʻĀpuka, ʻehaʻeha, hōʻulaʻalani,
• ka maʻi kūlohelohe: jarang - ka edema o Quincke, ka anaphylactic reaksi,
• metabolism a me ka meaʻai: pinepine - gout, anorexia,
• nā haʻawina a me nā mea noiʻi: pinepine - ka hoʻohaʻahaʻa iki ʻana i ka hemoglobin a me ka hematocrit, hyperkalemia, pinepine - he ulu iki i ka creatinine plasma a me nā ʻrea, ʻokoʻa loa - ka hoʻonui ʻana i ka hana o ka bilirubin a me nā hana o ka huina o ke kino, ʻike pinepine ka ʻike - he ʻemi i ka hoʻoliʻiliʻi sodium.
• nā hopena ʻē aʻe: pinepine - maulou, hōʻeha ka umauma, asthenia, pinepine - ʻokū, ka ʻōpū i ke alo, ʻike ʻole ke alapine - nāwaliwali, nā hōʻailona o nā maʻi like ʻole.

ʻO nā hopena ʻaoʻao o ka lāʻau Lozap plus, ma muli o nā kiko o ka hydrochlorothiazide i loko o kāna ʻano:

• gastrointestinal tract, ka ate a me ka tractary tract: pinepine - iha, ka mākala, ka luaʻi ʻana, gastritis, pancreatitis, nāwīwili o nā kelepa salivary, constipation a i ʻole nā ​​ʻōpū, cholecystitis, jaundice cholestatic.
• cardiovascular system: pinepine - - vasculitis (ʻili a i ʻole necrotic),
• lymphatic system a me ke koko: pinepine - - anemia (hemolytic a aplastic), agranulocytosis, thrombocytopenia, purpura, leukopenia,
• ʻōnaehana hanu: pinepine - paʻa ʻole i ka hanu ʻana, me ka edema pulmonary non-cardiogenic a me ka maʻi pīpī,
• nāūna nūpepa a me ka psyche: pinepine - poʻokela, pinepine ʻole - insomnia.
• nā ʻōhua nānā: ʻike pinepine - ʻike i nā mea i ka melemele, kahi manawa pōkole i ka ʻike ʻike,
• musculoskeletal system: pinepine - pinepine i ka io
• urinary system: pinepine - ka ole renal, interstitial nephritis, ke kahe ana o ka glucose i loko o ka urine,
• ʻili a me ka ʻili o ka subcutaneous: pinepine - i ʻole ka ʻōpala, ka photosensitivity, nā necrolysis epidermal,
• ka hiʻi kino: jarang - i ʻole nā ​​ʻano anaphylactic ʻano (i kekahi manawa a hiki ke pīhoihoi),
• ka umauma a me ka mea ʻai: pinepine - anorexia,
• nā haʻawina a me nā mea noiʻi: pinepine - ka hoʻohaʻahaʻa o ka sodium a me ka pākūkū i loko o ka serum, he hoʻonui nui ʻia o ka urric acid i loko o ke koko, hyperglycemia,
• nā hopena ʻē aʻe: pinepine - hānai, maʻi.

Ke keu

Me ka nui o Lozap i hoʻohui ʻia, ʻike ʻia nā hōʻailona like: ma muli o nā kiko o ka losartan - bradycardia, tachycardia, kahi kaila o ke koko ma muli o nā kikoʻī o ka hydrochlorothiazide - ka nalowale o nā electrolytes a me ka hoʻoheheʻe.

Hoʻomaʻamaʻa ka hoʻomaʻemaʻe overdose. Pono e hoʻōki i ka lawe ʻana i ka lāʻau lapaʻau, holoi i ka ʻōpū a lawe i nā hana e nānā ai i ka hoʻihoʻi ʻana i ka kaulike wai-electrolyte. Me ka hoʻemi nui ʻana o ke koko, e hōʻike ʻia ka mālama ʻana i ka maʻi infusion. ʻO ka hemodialysis e wehe i ka losartan he mea ʻole ia. ʻAʻole i hoʻokū ʻia ka kiʻekiʻe o ka lawe ʻana o ka hydrochlorothiazide e ka hemodialysis.

Nā ʻōlelo kikoʻī

Wahi a nā ʻōlelo kuhikuhi, hiki ke hoʻohana pū ʻia ʻo Lozap Plus me nā lāʻau lapaʻau anti antihypertensive.

I ka wā o ka mālama ʻana, pono ia e pale i ke nānā ʻana o kekahi mau hōʻailona i ka hōʻino ʻana o ka pauna ʻana o ka wai-electrolyte, e hoʻoulu kūʻē ʻana i ke kua ʻana o ka hoʻopiʻi a i ʻana i nā maʻi a i ʻole hōʻeha paha. I ia mau mea maʻi, pono nā kia hoʻonaninani ʻōlima.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a me nā mīkini paʻakikī

ʻAʻole i mālama ʻia nā noiʻi kūikawā e pili ana i ka hopena o ka lāʻau Lozap me ka hiki ʻana i ka mana psychomotor o ke kanaka. Eia nō naʻe, pono e noʻonoʻo i ka wā o ka mālama ʻana me nā lāʻau antihypertensive, inā hoʻi i ka hoʻomaka ʻana o ka hōʻola, hiamoe a ʻeha paha i ka maʻi, ka mea e hoʻopilikia ai i ka hopena o ka hopena a me ka hoʻokūkū ʻana.

ʻŌpū a me ka lactation

Hoʻokomo ʻia nā lāʻau hōʻino ma ka renin-angiotensin ʻōnaehana no ka hoʻohana ʻana i nā mea aloha a me ke kolu o ka hapaha o ka hapai, ʻoiai hiki iā lākou ke hōʻeha i ka make fetal. Ke hāpai ʻia ka hāpai ʻana, e hoʻolei ʻia ʻo Lozap.

ʻAʻole kuhikuhi ʻia ke koho ʻana i nā diuretics no nā wahine hāpai, no ka mea he nui ka loko o ka jaundice i ka pēpē a me ka pēpē, a me ka thrombocytopenia i ka makuahine.

ʻO ka lozap plus contraindicated i ka wahine lactating, ʻoiai hiki i ka thiazides ke hōʻeha i ka diuresis ikaika a pale i ka hana waiū.

Hoʻohui nūhou

ʻO ka hoʻohana like ʻana o Lozap a me ka diuretics pākeleka me ka paʻakai, nā mea kanu kalapona a me nā mea kanu paha i loaʻa nā mea e pili ana i nā paʻakai pākohu ʻaʻole i ʻōlelo ʻia (ʻoi ka nui o ke kō o ka paʻakai ma ke koko.

Hoʻonui ka Losartan i nā hopena therapeutic o nā lāʻau'ē aʻe e hoʻohaʻahaʻa i ke koko. No ke ʻano nui o nā lāʻau lapaʻau koʻikoʻi o losartan me ka cimetidine, ketoconazole, hydrochlorothiazide, phenobarbital, erythromycin, kūlohelohe anticoagulants a me digoxin.

Me ka hoʻohana like ʻana o ka diuretics thiazide a me kekahi mau lāʻau lapaʻau, hiki ke ʻike ʻia nā hōʻuluʻulu me kēia:

• nā lāʻau lapaʻau hypoglycemic no ka hoʻokūkū waha a me ka insulin - e koi paha i ka hoʻoponopono ʻana o nā kālā i helu ʻia.
• ethanol, analgesics narcotic, barbiturates - ua hoʻonui ʻia ka pilikia o ka hypotension postural (orthostatic).
• ʻO ka hormone adrenocorticotropic, corticosteroids - ka lilo ʻana o nā electrolytes, ʻoi aku ka nui o ka potassium
• Hoʻomoe lithium - ka hoʻonui ʻia o ka lithium intoxication,
• colestyramine, colestipol - ke hoʻemi ʻia ʻana o ka hoʻopili ʻana o ka hydrochlorothiazide,
• Non-steroidal anti-inflammatory drugs - hiki ke hoʻemi i ka diuretic, hypotensive a me natriuretic nā hopena o ka diuretics,
• nā mīkini paʻi, (adrenaline, etc.) - kahi i liʻiliʻi o ko lākou hopena i nānā ʻia,
• non-depolarizing muscle hoʻomaha (tubocurarine chloride, etc.) - hiki i e hoʻoikaika ʻia kā lākou hana,
• probenecid, allopurinol, sulfinpyrazone - pono koi hoʻoponopono hoʻoponopono i kēia mau lāʻau,
• salicylates - hiki iā ia ke hoʻonui i ka hopena ʻalika o nā salicylates ma luna o ka pūnaehana poʻomanaʻo,
• nā lāʻau lapaʻau cytotoxic - hiki ke hoʻonui ʻia ko lākou hopena myelosuppressive,
• cyclosporine - i kahi hoʻopiʻi ʻana o ka gout a me ka piʻi nui o ka hyperuricemia,
• metyldopa - i nānā pinepine ʻia nā anemia hemolytic,
• hiki i nā anticholinergics - ke hoʻonui i ka bioavailability o hydrochlorothiazide hiki,
• nā lāʻau lapaʻau antihypertensive ʻē aʻe - e nānā ʻia kahi hopena hoʻohui.

ʻO nā hui a Lozapa plus e: Lozartan, Lozartan-N Canon, Lozartan-N Richter, Lorista, Lorista N, Lorista N 100, Lakea, Lozarel, Cozaar, Centor, Presartan.

Hōʻike ʻia ma Lozap Plus

Wahi a nā loiloi, ʻo Lozap Plus kahi lāʻau lapaʻau e hoʻemi ai i ke koko kiʻekiʻe. Hoʻomaopopo ka poʻe maʻi ʻaʻole wale ia e kōkua maikaʻi me ka hypertension arterial, akā pale pū i ka hoʻomohala ʻia o kekahi mau maʻi cardiovascular. ʻO ka Lozap me ka wikiwiki e hoʻoemi i ka pīpī a maikaʻi i ka wā. ʻO nā pono o ka lāʻau lapaʻau, ka hilinaʻi, maʻalahi i ka hoʻohana (hoʻokahi lā i kahi lā), ʻike ʻia ka hopena ʻoluʻolu a me ka palekana.

Nā hemahema o ka lāʻau i loko o kekahi mau loiloi e pili ana i nā hopena ʻaoʻao e hiki iā Lozap plus ke kumu, a me ka ʻoiaʻiʻo ke hana maikaʻi wale nei me ka hoʻohana maʻamau. Ke hoʻopiʻi nei kekahi mau maʻi i kāna kumukūʻai nui (ʻoi aku ka maikaʻi o ka kūʻai ʻana i ka lāʻau i loko o nā paʻi nui).

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana a me ka pōpoki

ʻO ka lāʻau "Lozap plus" nona nā pūʻulu o nā lāʻau antihypertensive. ʻO waho, he papa papa a ʻulaʻula paha a me ke keʻokeʻo paha, oblong ʻano. Hoʻopili ka kiʻiʻoniʻoni i ka lāʻau. Aia kahi pale i nā ʻaoʻao ʻelua o nā papa. I kahi pahu pā i 10 o 15 mau pālima, i hoʻopaʻa ʻia i ka pōpō pepa. Loaʻa i nā papa Lozap 2 mau huahana ikaika - potoma losartan a me hydrochlorothiazide. ʻO kā lākou papa papa he 50 mg a me 12.5 mg, kēlā ʻO nā mea kōkua

Nā hōʻailona no ka koho

ʻO nā ʻōlelo i hoʻohana ʻia e hiki i ke "Lozap Plus" hiki ke lilo i lāʻau lapaʻau kaʻawale i loko o ka lāʻau a i ʻole ka mea pili i ka terapi paʻakikī. Ma mua o ka hoʻohana ʻana, e kamaʻilio i kāu kauka. He mea kūpono ia e noʻonoʻo ʻo "Lozap" a me "Lozap plus" i aneane like a me nā hopena o ka hopena a me ka mālama ʻana. Ke hōʻike nei i ka hoʻohana ʻana:

• kahi ulu kiʻekiʻe o ke koko i ka manawa mau a i ʻole nā ​​manawa maʻamau,
• ma ka ʻāpana o ka mālama ʻana i ka mālama ʻana o ka puʻuwai naʻau ʻole,
• me ka pale ʻana o nā maʻi o ka ʻōnaehana cardiovascular,
• me nā hōʻikeʻike o ka maʻi hānai me ka hypertension.

Nā ʻōkuhi no ka hoʻohana a me ke ʻano o ka lāʻau lapaʻau "Lozap plus"

ʻO ke ala o ka noi a me nā ala ʻokoʻa i hoʻokaʻawale i nā mea i wehe ai ʻo Lozap mai Lozap Plus. He pololei ke inu i ka 1 papa (50 mg o losartan) i ka lā. ʻAʻohe mea e pili ai i ka meaʻai. Inā hala ka manawa, ʻaʻole e emi iho ke kaumaha e like me ka mea e pono ai ke kanaka, pono e hoʻonui ʻia ka dosage. ʻOi aku ka maikaʻi ke lawe ʻole i nā papa ʻelua ma mua o kēlā me kēia lā. Hoʻopilikia ʻia kēia me nā hopena olakino. I mea e pale ai i ka maʻi cardiovascular, ua lawa e lawe i ka 1 pil i ka lā. Inā kuhikuhi e ke kauka iā Lozap 100, hapalua nā papa i kēlā me kēia lā (50 mg) ua lawa. Ma mua o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa, pono ʻoe e kamaʻilio i ke kauka a me ka hoʻomaʻamaʻa.

Hoʻohui ka lāʻau

ʻO ka lāʻau lapaʻau "Lozap Plus" i kuhikuhi ʻia e nā kauka e hoʻohui i ka lāʻau maʻamau. He mea nui e noʻonoʻo i ka hoʻohui a me ka hoʻopili ʻana o nā mea ikaika. Hōʻike ka mea hana i ka hopena o losartan ma luna o nā lāʻau lapaʻau hou i ka annotation. Me ka hoʻokele like ʻana me nā lāʻau antihypertensive, e wikiwiki loa ka ke kaumaha. Hoʻomaopopo ka nui o nā papa pākia me ka wā e hui pū ʻia me nā mea hoʻomohala kalima. ʻO ka emi ʻana o ka hopena e nānā pono i ka wā e hui pū me nā lāʻau anti-inflammatory non-steroidal. Hoʻomaka ʻia ka hoʻomaka ʻana o ka hoʻohana ʻana i kekahi mau lāʻau lapaʻau i ka manawa like.

ʻŌpū a me ka lactation

ʻO "Lozap Plus" a i ʻole "Lozap" i ka wā hāpai a papa ʻia. He mea kūpono kēia no nā wahine e hoʻolālā ana i kahi hāpai a me nā malama ʻekolu o ka hānau ʻana. ʻO kēia ma muli o ka hopena maikaʻi o nā mea o ke ʻano ma ka pūpū. Hiki iā Losartan ke komo i loko o ka waiū umauma. No kēia kumu, pono ke aʻa ka mālama i ka wā mālama. Hiki iā ʻoe ke hoʻihoʻi i ke keiki i ka hana kūlohelohe i 2 mau lā ma hope o ka pau o ka hana hope.

Na keiki a me ko elemakule

ʻAi ʻia ka makahiki a hiki i ka 18 makahiki no ka lawe ʻana iā "Lozap Plus". Hoʻomaʻamaʻa ka mea hana i nā pōʻino o ke komo ʻana. No nā poʻe maʻi maʻi, ʻo ka dosage mua o 50 mg i kēlā me kēia lā. I kēia hihia, pono ʻoe e kiaʻi mau i kāu pono a lawe i nā hoʻokolohua hoʻoliʻi. Inā ʻaʻole pono, pono ke loli ke ʻano o ka lāʻau lapaʻau i nā lāʻau like ʻole a like ʻole paha.

No nā pilikia o ka pēpē a me ka pilikia

ʻO "Lozap plus" e hoʻohana ʻia me ka mālama aka ʻana i ka hana o ka puʻuwai i hōʻemi ʻia ma mua o ka 9 ma ka pae o Child-Pugh. ʻAʻoleʻoi aku ka nui o nā paena ma mua o ka 1 pill i kēlā me kēia lā. Me ka hoʻomohala ʻana o ka hana paleka, ʻaʻole pāpā. ʻO nā hemahema i ka hana o nā mea olelino o ka genitourinary e koho pono ai i ka koho ʻana o ka nui a me ka lōʻihi o ka mālama ʻana. ʻO ka mea nui ka nānā ʻana o ka urine laboratorium.

Nā pena like ʻole

Inā loaʻa nā contraindications i ka lāʻau lapaʻau "Lozap plus" a inā i hemahema ka mea i loko o ka lāʻau lapaʻau, pono ʻoe e koho i kahi mea. I kēia hihia, pono ke ʻano like o ka mea hana me ka kumu mua, ʻoiai e hoʻopili pono ana i ka mea maʻi. Ke lawe ʻia nei ke koho e ke kauka nei e mālama i ka mōʻaukala olakino. ʻO nā mea pono e hiki ke loaʻa iā Cardomin, Co-Centor, Losartan, Lorista, Nostasartan, Logzartik Plus, Kandekor a me Valsartan.

Nā hōʻailona no ka hoʻohana ʻana

Hāʻawi ʻia ʻo Lozap Plus e hoʻohana ʻia ma ke ʻano o ka paʻakikī paʻakikī o ka hypertension arterial i loko o nā poʻe maʻi no ka mea ʻoi aku ka maikaʻi o kēia ʻano lapaʻau. Lawe ʻia ka lāʻau no ka hypertension arterial a waiho aku i ka hypertrophy ventricular i mea e hōʻemi ai i ka hopena o ka hoʻomohala ʻana i nā ala cardiovascular a me ka make ma mua.

Nā ʻōkuhi no ka hoʻohana ʻana i ka Lozap Plus: kaʻina a me ka ʻihi

Lawe ʻia nā papa Lozap Plus ma ke alo, me ke ʻano o ka manawa ʻaina.

Palapala ʻia e like me nā hōʻike ʻana:

• hypertension arterial: hoʻomaka a me ka mālama mālama ʻia - 1 papa i kēlā me kēia lā, me ka ʻole e hoʻokō kūpono i ka hiki ʻana o ke kahe o ke koko, hiki ke hoʻonui ʻia i kēia momona a hiki i nā papa papaʻa 2 mau manawa 1 i kēlā me kēia lā, hiki i ka hopena hypotensive ka hopena i ka lāʻau i loko o 3 mau pule mai ka hoʻomaka ʻana o ka hopena,
• ka hōʻemi ʻana i ka hopena o ka maʻi o ka maʻi cardiovascular a me ka make ma ka poʻe maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular: a ʻo ka helu hoʻomaka ʻana o losartan he 50 mg / lā, i ka hemahema o ka mākaukau a me ka pae nui o ka pae koko a me ka monartan monotherapy, ka hui pū ʻana o losartan me hydrochlorothiazide ma kahi haʻahaʻa e koi ʻia ( 12.5 mg), ka mea i hōʻoia ʻia e ka hoʻohana ʻana i ka lāʻau Lozap Plus, inā pono, hiki ke hoʻonui ʻia i kēia momona i nā papa 2 i ka manawa 1 i kēlā me kēia lā (100 mg o losartan + 25 mg o hydrochlorothiazide).

Me ka hana pūpū hemahema

Wahi a nā haʻawina pharmacokinetic i nā maʻi me ka cirrhosis, ʻike ʻia kahi hoʻonui nui ʻana i ka plasma o losartan. ʻO ka diuret Thiazide, me ka hydrochlorothiazide, hiki ke hōʻeha i ka cholestasis intrahepatic, a me nā haunaele liʻiliʻi i loko o ka hoʻōla wai-electrolyte hiki ke hoʻowalewale i ka hoʻomohala ʻana o ka coma hepatic. No kēia pili, ua kau ʻia ʻo Lozap Plus me ka mālama aka ʻana i ka hana o ka puʻuwai maʻi (me ka mōʻaukala) a me nā maʻi ʻōmaʻomaʻo holomua. Ma nā hōʻino koʻikoʻi o ka hana o ka ate, ua contraindicated ʻo ka hoʻohana ʻana i ka lāʻau.

ʻO ka hole waiwai

• barbiturates, inu wai, analio opioid, antidepressants: loaʻa ka hopena o ka orthostatic hypotension,
• antidiabetic drug (insulin a me hypoglycemic agents no ka hoʻokō waha): hiki i ka hydrochlorothiazide ke hoʻopilikia i kā lākou glucose, i makemake ai i ka hoʻoponopono ʻana,
• metformin: hiki i ka hoʻomohalaʻana o ka acidact lactic, ma muli o ka hana renal functioning ma muli o ka hoʻohana ʻana o hydrochlorothiazide, pono e mālama pono i ka wā i hoʻohana pū ʻia,
• nā lāʻau lapaʻau antihypertensive ʻokoʻa: ʻo nā sinnergies o ka hana e kōkua i ka hoʻomohala ʻana i kahi hopena hoʻohui,
• colestyramine, colestipol: ion-exchange resins pale i ke kahe ʻana o ka hydrochlorothiazide, hoʻokahi pākahi o colestyramine / colestipol alakaʻi i ka pili ʻana o ka hydrochlorothiazide a hoʻoemi ʻia i kona lawe ʻole ʻana mai ke kaila gastrointestinal e 85% / 43%,
• corticosteroids, adrenocorticotropic hormone (ACTH): hiki ke hoʻonui i ka nele o nā electrolytes, ʻoi aku hoʻi ka hypokalemia,
• nā mea hana lima (adrenaline): paha i kahi emi i ka hana, ʻaʻole hoʻokaʻawale i kā lākou hoʻohana ʻana,
• hoʻomaha ʻole i ka hoʻomaha ʻana i ka manawa (tubocurarine chloride): hiki i ka hydrochlorothiazide ke hoʻonui i kā lākou hopena,
• lithium mākaukau: diuretics, a me ka hydrochlorothiazide, hōʻemi i ko lākou hoʻomaʻemaʻe kino, e hoʻonui nui i ka hopena o nā hopena o nā lithium, e'ōlelo ʻia ka hoʻohana like ʻana e ʻalo ʻia,
• anti-gout drugs (sulfinpyrazone, probenecid, allopurinol): pono e hoʻoponopono ʻia ka dosage, no ka mea hiki i ka hydrochlorothiazide ke hoʻonui i nā pae waikū o serum, e hoʻomāhuahua paha ka hoʻonui ʻana i ke ʻano o nā hopena aler i ka allopurinol.
• nā lāʻau anticholinergic (atropine, biperidine): hiki ke hoʻonui i ka bioavailability o hydrochlorothiazide ma muli o ka hoʻokuʻuʻana i ka hoʻomau a gastrointestinal a me kahi hoʻohaʻahaʻa i ka hapa o ka gastric kalaʻa ʻana.
• cytotoxins (methotrexate, cyclophosphamide): hiki ke hoʻokaʻawale i kā lākou excretion ma o ke keiki a hoʻonui i ka hopena myelosuppressive,
• salicylates: i ka wā i hoʻohana ʻia ai i nā helu kiʻekiʻe, hiki ke hoʻonui ʻia kā lākou hopena o ka pehu i ke kikowaena o ka pūnao waena (CNS)
• methyldopa: ua hōʻike ʻia nā manawa kaʻawale o ka hoʻomohala ʻana o nā anemia hemolytic,
• cyclosporine: hoʻonui koʻikoʻi o ka hyperuricemia a me nā hoʻopiʻi o ka gout,
• glycosides cardiac: hypokalemia / hypomagnesemia i kumu ʻia e ka hydrochlorothiazide e hoʻomohala i ka hoʻomohala ʻana o ka arrhythmias digitalis-induced,
• glycosides digitalis, nā lāʻau lapaʻau antiarrhythmic (ka hopena o ka hopena e pili ana i ka pae o ka serum potassium), nā lāʻau IA antiarrhythmic drug (hydroquinidine, quinidine, disopyramide), nā papa lāʻau o ka antiarrhythmic III (amiodarone, dofetilide, ibutilide, sotalol), kekahi antipsychotazine (thidromomaz) , trifluoperazine, cyamemazine, sultopride, sulpiride, amisulpride, pimozide, setiapride, droperidol, haloperidol), nā lāʻau lapaʻau ʻē aʻe e hiki ai ke hōʻeha i ka tachycardia ventricular o ka ʻano pirouette (difemanil, bepridil, cisapride, erythromycin intravenously, halofantrine, pentamidine, misolastine, terfenadine, vincamycin intravenously): ua hoʻolako ʻia e mālama pono i nā pae o ka serum potassium, ʻoiai hypokalemia he kumu predisposing i ka hoʻomohala ʻana o ka pyruet tachycardia, a me ka mālama ʻia ʻana o ka electrococardio)
• ka paʻakai kalala: hiki i ka hydrochlorothiazide ke hoʻonui i ka pae o ka calcium ma ka serum ma muli o ka hoʻokaʻawale ʻana i kona excretion, pono ia e nānā i ka pae o ka calcium serum a me kahi hoʻoponopono kūpono o ka hoʻoponopono nui o ka hoʻomākaukau ʻana i ka calcium, ma muli o ka hopena i ka metabolism o ka calcium, hiki i ka hydrochlorothiazide ke hoʻololi i nā hopena o nā loiloi hana parathyroid,
• ka hoʻohālikelike ana i ka ʻailaama: e nānā pono ai ke nānā ʻana i nā maʻi o ka sodium a me nā mākaʻi o ke kō o ka paʻakai o ka paʻakai i ka poʻe maʻi e hoʻohana ana i ka carbamazepine, ma muli o ka hopena o ka hoʻomohala ʻana i ka hyponatremia hōʻailona.
• nā mea ʻokoʻa a ka iodine: me ka huhū i hoʻomake ʻia e ka diuretics, ʻo ka loaʻa ʻana o ka pilikia o ka hoʻoulu ʻana i ka maʻi renal maʻamau e hoʻonui ai, ʻoiai inā lawe aku i ka hoʻomākaukau ʻana i ka iodine i nāosa kiʻekiʻe, no laila koi ka rehydration ma mua o ka hoʻokele
• amphotericin B (parenteral), glucocorticosteroids, ACTH hoʻoulu i ka laxatives a i ʻole glycyrrhizin (i loaʻa i ka licorice): hiki i ka hydrochlorothiazide ke kumu o ka nele o ka electrolyte, keu hypokalemia.

ʻO nā analogues o Lozap Plus ʻo: Gizaar, Gizaar Forte, Hydrochlorothiazide + Lozartan TAD, Blocktran GT, Lozarel Plus, Lozartan-N Canon, Lozartan N, Lozartan / Hydrochlorothiazide-Teva, Presartan N, Lorista N 100, Lorista N, Siman Nd.

Hōʻike ʻia ma Lozap Plus

ʻO nā mea maʻi i koho iā Lozap Plus e hoʻohaʻahaʻa i ko lākou puʻuwai e waiho i nā loiloi maikaʻi loa. Kākau lākou ʻo ka lawe ʻana i nā papa i hoʻokahi manawa i kahi lā e hoʻomaikaʻi maikaʻi i ka hoʻomaʻamaʻa ʻana, me ka hōʻemi ʻana i ka pīpī, a pani ʻana i ka dizz. Ke hopohopo nei kekahi poʻe i ka diuretic hopena o ka lāʻau a makemake paha i ka hoʻopōʻino me ka hoʻohana mau ʻana.

ʻO nā mea maʻi me ka manaʻo e huehue i ke kāohi ʻana e haʻalele iā Lozap Plus e hoʻomaka ai, no ka mea, ua contraindicated ka diuretics i ka wā o kāna alakaʻi, a i ʻole e hoʻoponopono i kona lawelawe ʻana me nā papa o nā lāʻau antihypertensive.

Lozap a: nā ʻōlelo no ka hoʻohana ʻana (ma ke ʻano a me ke ʻano)

Lawe ʻia ka papa Lozap a i nā waha maʻamau, me ka ʻole o ka manawa e ʻai ai.

Nā kuhikuhi i hōʻike ʻia:

• hypertension arterial: hoʻomaka a me ka mālama mālama - 1 papa i kēlā me kēia lā. Inā ʻaʻohe hopena ma ke ʻano o ka hoʻokō kūpono i ke kō o ke koko, hiki ke hoʻonui ʻia i ke kala ma kahi o nā papa ʻelua o hoʻokahi i hoʻokahi lā. Loaʻa ka hopena hypotensive kiʻekiʻe i loko o 3 mau pule ma hope o ka hoʻomaka ʻana o ka hōʻola,
• hypertension arterial a waiho aku ai i ka hypertrophy ventricular - e hōʻemi i ka hopena o ka hoʻomohala ʻana i nā maʻi cardiovascular a me ka make: ʻo ka helu mua ʻana o losartan he 50 mg hoʻokahi i ka lā. Inā, i ke kūpaʻa o ka monotherapy me ka losartan, ʻaʻole hiki ke hoʻokō i ka pae pae o ka pehu o ke koko, pono e koho i ka hui hoʻohui ʻana o ka losartan me ka hydrochlorothiazide i kahi haʻahaʻa haʻahaʻa (12.5 mg). Inā kūpono, hiki ke hoʻonui ʻia ka nui o ka losartan i 100 mg / lā i hui pū me ka hydrochlorothiazide ma ke ʻano o 12,5 mg / lā. I ka wā e hiki mai ana, hiki i ka nui o ke hoʻonui ʻana i ka nui i loko - 2 mau papa Lozap i hoʻokahi manawa i ka lā.

Me ka hana pūnāwai paʻa ʻole

Wahi a nā ʻōlelo kuhikuhi, ʻo Lozap plus e pono e hoʻohana me ka akahele me ka poʻe maʻi me ka stenosis bilateral renal aren stenosis a i ʻole ke kaulua o ka stenosis o hoʻokahi keiki, ʻo ia hoʻi i ka poʻe maʻi e hōʻaiʻe hou ana i nā hana hoʻohālikelike.

Aia ke hōʻike ʻana i ka hiki ʻana o ka pilikia papau ma muli o ka pale ʻana o ka losartan e ka ʻina renin-angiotensin-ald testosterone i loko o nā mea maʻi me ka loaʻa ʻole o ka naʻau a i ʻole ka loaʻa ʻole o ka pilikia ʻole. Hiki i ka Losartan ke hoʻonui i ka hoʻoili o ka urea a me ka mea hana i loko o ke koko koko i loko o nā mea maʻi me ka stenosis bilateral renal artery stenosis a i ʻole stenosis stenosis o hoʻokahi keiki. Hiki ke hoʻololi hou ʻia ka loli ʻana i ka hana o ka peʻapeʻa a hoʻemi ʻia ma hope o ka hoʻokuʻu ʻana o ka lāʻau lapaʻau.

ʻO ke kumu o Lozap a i ʻole no ka hōʻino ʻana i ka maʻi haneli (ʻo ka hana ʻana i hana ʻia ma lalo o 30 ml / min) i contraindicated.