Nā ʻōkuhi no ka lāʻau Simbalta - i ka wā pono a me ka manawa hiki ʻole iā ʻoe ke hoʻohana i kēia lāʻau lapaʻau

Minamina, ʻo kēlā me kēia makahiki ka nui o ka nui o nā poʻe i kū i ke kaumaha, nū a me nā pilikia i ka noʻonoʻo. He paʻakikī ke haʻi i ke kumu, akā ʻo ka wikiwiki o ke ola, ka hana kuleana, ka nele o ka hoʻomaopopo i ka ʻohana, nā pilikia i ka ola pilikino - hiki i kēia mau mea ke hāʻawi i kahi ʻano hana i ka pīhoihoi, a i ʻole ka hopena a kahi neurosis a i ʻole ke kaumaha.

I kēlā mau maʻi a kānalua paha o ia mau mea, pono e hoʻopili i nā psychotherapists, neurologists. Hoʻohana pinepine, ʻaʻohe mea i kōkua ʻia, ʻaʻole hiki i kahi kanaka ke hele i waho o kahi kūlana i hoʻokaumaha ʻia a hoʻomau i ke ola maʻamau. Eia kekahi, pinepine ia mau maʻi i mea e pōʻino ai: nā pepehi kanaka, make, ma muli o kahi kūlana hopohopo, ka nele o ka hauʻoli a me ke ʻano o ke ola.

I ka hapanui pinepine, e hoʻihoʻi hou i ke kino, kaukaʻi nā kauka e mālama i kahi papa o antidepressants, kahi i ka manawa pōkole hiki ke hoʻihoʻi i kahi kanaka i ke ola.

ʻO kekahi o nā lāʻau lapaʻau o ka hui antidepressant ʻo ia ka laʻa Simbalta i hōʻike pinepine ʻia e nā kauka i nā maʻi.

He lāʻau lapaʻau koʻikoʻi ʻo Simbalta, ka loaʻa ʻole o ka loaʻa ʻole me ke koho ʻana i kahi kauka a me ka nānā maʻamau ʻana i ke ʻano o ka mea maʻi!

Nā hana lāʻau

ʻO ka ʻōlelo o ka lāʻau lapaʻau Symbalta hōʻike e pili ana ka hopena o ka lāʻau lapaʻau i ke kaʻina hana o ka hoʻoulu hou ʻana o ka serotonin, e like me nā mea āpau e like me ka hana like. Inā mākou e kamaʻilio e pili ana i ka inoa inoa o ka lāʻau lapaʻau, a laila hiki ke loaʻa ma ka inoa ʻo Duloxetine. ʻO kēia kēia mea e ikaika ai.

Nā Hoʻohui

E like me kēlā me kēia lāʻau lapaʻau, loaʻa i ka lāʻau lapaʻau nā contraindications. I loko o nā maʻi a me nā kūlana hope loa, ʻaʻole lawe ʻia ka mālama ʻana me kēia lāʻau lapaʻau.

me ka ulu ʻana o ka naʻau ikaika i ka hopenaxxine,
hana hoʻohua - nā mea paʻa MAO,
i ka wā ʻōpiopio,
me ka loaʻa ʻana o ka koki-kūkaʻa glaucoma,
malalo o na makahiki he 18.

ʻO ka mālama a ma lalo o ka mākaʻi o ke kauka, hiki i ka lāʻau lapaʻau ke hoʻohana i nā hihia o ka exacerbation o ke kūlana manic a me hypomanic, ʻaʻole wale i kēia manawa, akā i ka anamnesis. Pili ka pili i ka epilepsy (me ka mōʻaukala olakino). Ma lalo o ka mākaʻi o ke kauka e pono i nā mea maʻi me ka piha o ka renal a me ka maʻi hepatic, me ka loaʻa ʻole o ka hoʻomohala ʻana i ka glaucoma sudut-pani.

I ka wā hāpai, hoʻohālikelike ʻia ka lāʻau lapaʻau e like me ke kuhikuhi ʻana a kahi loea. I ka hihia o ka ʻokoʻa ʻana o ka hoʻāʻo ʻana e pepehi ʻia, hiki iā ʻoe ke hoʻohana iā Simbalta ma lalo o ka nānā ʻana o kekahi kauka.

Loaʻa nā hopena kūpono o ka mālama ʻana

He lāʻauʻino nui ka lāʻau lapaʻau, no ka mea ke loaʻa nā ʻōlelo no Simbalta ka papa helu piha o nā hopena ʻaoʻao hiki paha ke kū mai ke mālama ʻana iā lākou.

Ma kahi o 10% o nā hihia (a ua manaʻo ʻia kēia ʻano hopena maʻamau), ʻeha, ka hoʻohālikelike ʻana i ka hiamoe (a ʻo ka ʻūhina, a me ka puʻuwai ʻē aʻe), nausea, waha maloʻo, constipation, a me ke poʻo hōʻeha ʻoiai ke lawe ʻana iā Simbalt.
ʻOi aku ka liʻiliʻi ma waena o nā mea maʻi e lawe aku ana i ka lāʻau, ka maʻi ʻeha, ka hoʻohaʻahaʻa i ka momona a me ke kaumaha o ke kino ma kēia ʻano, nā haʻalulu, nā ʻūhū, ka hoʻoneʻe ʻana i ka moʻo ʻana o ka wahine nā pilikia, nā pilikia kīwī, i ke ʻano o nā kiʻi, a ʻo nā kāne ke hoʻēmi i ka potency, ejaculation disorder . ^ E Ha yM.
ʻO nā mea maʻi me ka neuropathy maʻi maʻi i ka wā e mālama ai me Simbalt i hāpai i ke kiʻekiʻe o ka glucose koko ke hele nei i kahi hoʻokolohua ʻole ʻole o ka ʻōpū.

Eia kekahi, hiki ke hōʻeha i nā hopena ʻaoʻao i ka wā o ka lāʻaleʻa i hoʻokuʻu ʻia: i waena o nā hōʻailona hoʻihoʻi, hōʻike ka poʻe maʻi i nā hōʻeha, hōʻeha, a me ka hōʻino.

I nā hihia o ka lāʻau overdose, puaʻa, hoʻohaʻahaʻa i ka makemake, ataxia, koi, hoʻoweliweli. ʻAʻole i ʻike ʻia kahi hopena antidote no ka lāʻau Simbalta, no laila, i ka wā e mālama ai, pono lākou e mālama pono i ka hana i kuhikuhi ʻia e ke kauka.

Pehea e lawe ai i ka lāʻau

ʻAʻole mālama ke kaona o Simbalta i ka hoʻokomo ʻana i ka meaʻai. ʻO ke ʻano o ka lāʻau lapaʻau ka kapili enteric. E pono iā lākou e ʻāʻī ʻole ke kahakaha ʻole i ka palaualelo. ʻAʻole hāʻawi ʻia ka lulu ʻana i ka wai me ka hoʻohuihui ʻana me ka meaʻai.

Hoʻolālā pinepine ʻia i hoʻokahi lā i ka pae a 60 mg. Inā pono, e hoʻonui i ka dosis i ka 120 mg a lawe i ka lāʻau lapaʻau ʻelua i kēlā me kēia lā. Manaʻo ʻia he dosage o 120 mg kahi nui loa no ka hoʻohana ʻana i kēlā me kēia lā.

I ka hana ʻole, ua hoʻemi ʻia ka hāmua mua i 30 mg i kēlā me kēia lā.

Pono e hoʻomanaʻo ʻia ʻo ka lawe ʻana iā Simbalta i pale aku i ka hopena psychomotor, hiki ke hoʻemi i ka hana hoʻomanaʻo.

No laila, i ka wā o ka mālama ʻana me kēia antidepressant, pono e kaupalena i ka hana ma nā hana ʻehaʻeha loa kahi e koi ʻia ai ka hoʻonui ʻana o ka manaʻo a me ka wikiwiki o ka hopena.

E hoʻokuʻu i ke ʻano a me ka ʻano

Nā ʻano hoʻohālikelike - nā kapo: paʻakikī, gelatin, opaque:

30 mg: ka nui No. 3, me kahi pāpale uliuli kahi i kau ʻia ai ke code identifying "9543" i loko o ke aniani ʻōmaʻomaʻo, a me kahi keʻokeʻo kahi e kau ʻia ai ka hōʻailona ma ke ʻano he 30 mg "i loko o ke aniani māla.
60 mg: ka nui No. 1, me kahi pāpale uliuli kahi i kau ʻia ai ke code identifying "9542" i loko o ke aniani keʻokeʻo a me kahi hihia ʻōmaʻomaʻo ka pili ʻana o ka mana ma ka "60 mg" ma kahi aniani keʻokeʻo.

ʻO nā mea o nā kapoti: nā pōkole mai ke keʻokeʻo a hiki i ka hina-keʻokeʻo.

Hoʻopili ʻana i ka hoʻomākaukau: 14 mau kīleʻa i loko o kahi bele, i kahi pā kāleka o 1, 2 a i 6 paha blister.

ʻO ka waiwai koʻikoʻi: pitoxetine (ma ke ʻano o ka hydrochloride), i ka kiola 1 - 30 a 60 mg paha.

nā manaʻo o ka capsule: triethyl citrate, granulated sugar, sucrose, hypromellose, succinate, hypromellose acetate, talc, kahe keokeo (hypromellose, titanium dioxide).
ʻālepili: gelatin, indigo carmine, sodium lauryl sulfate, titanium dioxide, a me ka hao ʻelehe waioneʻe - i loko o nā aka 60 mg,
overprint: 30 mg capsules - TekPrint ™ SB-4028 ke aniani ʻōmaʻomaʻo, 60 mg capsules - TekPrint ™ SB-0007P ke aniani keʻokeʻo.

Nā hōʻailona no ka hoʻohana ʻana

ʻO ka hopohopo nui i ke kaumaha (GAD),
manaʻo ʻino
nā ala ʻeha o ka neuropathy maʻi maʻi peripheral,
ʻeha ka maʻi o ke ʻōnaehana o ka musculoskeletal system (me ka mea i hoʻokumu ʻia e ka osteoarthritis o ka ʻāʻī o ke kuli a me nā fibromyalgia, a me ka hōʻeha nui i ke kua lalo).

ʻLoe a me ke kākele

Pono e lawe ʻia i nā papa ʻōlelo: ʻoki loa a inu i ka wai. ʻAʻole pili ka ʻai i ka hopena o ka lāʻau, akā, ʻaʻole pono e hoʻohui ʻia nā papa i ka meaʻai a i hui pū ʻia me nā wai wai!

Nā mea hoʻoponopono lula kumu:

ka makehewa: ka mua a me ka maʻamau mālama mālama 'ana - 60 mg hoʻokahi i ka lā. Hōʻike pinepine ʻia kahi hoʻomaikaʻi ʻana ma hope o 2 mau pule o ka lawe ʻana i ka lāʻau lapaʻau, naʻe no ka pale ʻana i ka iho ʻana, kauoha ʻia ka hoʻomau ʻia no kekahi mau mahina. Ma nā hana pinepine o ke kaumaha i nā poʻe maʻi e pane maikaʻi ana i ka mālama ʻana me ka endxetine, mālama lōʻihi ka lōʻihi o ka paena o 60-120 mg, hiki
ʻO ka hopohopo ʻōiwi maʻamau: 30 mg ka mea i manaʻo ʻia e hoʻōki, inā lawa ka hopena, ua hoʻonui ʻia i 60 mg. Ma kahi o ke kaumaha hoʻopulapula, ʻo ka mua a me ka mālama ʻana i kēlā me kēia lā he 60 mg, me ka pane ʻole ʻana o ka ʻanā ʻana, e hoʻonui ʻia ai ka 90 a 120 mg paha. I mea e pale ʻole ai i ka hūnā, e noi ʻia e mālama ʻia ke ʻano no kekahi mau mahina.
ʻeha ʻeha o ka maʻi neuropathy maʻi peripheral: mua a me ka mālama mālama maʻamau - 60 mg hoʻokahi manawa i ka lā, i kekahi mau manawa hiki ke hoʻonui ʻia i kēlā me kēia lā i 120 mg. Hōʻike ʻia ka loiloi mua o ka pane ʻana i ka therapy ma hope o 2 mau mahina o ka mālama ʻana, a laila - ma kahi o hoʻokahi manawa i kēlā me kēia 3 mahina,
ʻeha ka maʻi ʻeha o ka musculoskeletal system: ʻo ka pule mua o ka maʻi - 30 mg hoʻokahi manawa i ka lā, a laila 60 mg hoʻokahi i ka lā. ʻAʻole hoʻolako ka hoʻohana ʻana i nā dosis i kahi kiʻekiʻe e ʻoi aku ka hopena maikaʻi aʻe, akā e hoʻopili pū me ka kiʻekiʻe o nā hanana ʻino. ʻO ka lōʻihi lōʻihi o ka mālamaʻana a hiki i ka 3 mau mahina. ʻO ka hoʻoholo e pili ana i ka pono e hoʻonui i ka papa o ka lapaʻau i hana ʻia e ke kauka e hele ana.

I loko o nā hebedoma mua o ka mālama ʻana i ka GAD, ua kuhikuhi ʻia nā poʻe maʻi kahiko iā Simbalt i loko o kahi mehana i kēlā me kēia lā o 30 mg, a laila, me ka hoʻomanawanui maikaʻi, hoʻonui ʻia ke ʻano iā 60 mg. I ke koho ʻana i ka lāʻau lapaʻau no nā hōʻailona ʻē aʻe, ʻaʻole pono ka poʻe kahiko i ka hoʻoponopono ʻana i ka wai.

Pono e ʻokiʻoki i ka hōʻemi ʻana o ka lāʻau, ʻoiai e ulu ka maʻi withdrawal. Hoʻomaopopo ʻia e hoʻemi i ka iki ma luna o kahi manawa o 1-2 mau pule.

Nā hopena hopena

ʻO ka hapa nui o nā hopena kūpono he haʻahaʻa a maʻalahi paha, i hoʻomaka i ka hoʻomaka ʻana o ka mālama ʻana a i ka wā o ka hoʻolaʻa, ʻike ʻia ko lākou hōʻeha.

I nā haʻawina loea, ua hōʻike ʻia nā hopena hōʻino mai kēia mau ʻōnaehana a me nā kino hou:

ʻO ka maʻi gastrointestinal: pinepine loa - waha maloʻo, nausea, constipation, pinepine ka dyspepsia, luaʻi a me ka ʻōpū, ʻōpū, ʻōpū, ka ʻōpū, ka puʻupuʻu - belching, dysphagia, gastritis, gastroenteritis, gastrointestinal ka huhū, ʻokoʻa - ka hanu maikaʻi ʻole. stomatitis, ke kīwaha koko.
ʻO ka maʻi a me ka biliary tract: pinepine - pili i ka maʻi pāpaʻi, hepatitis, līpoki - jaundice, hōʻeha ate,
ʻO ka Metabolism a me ka meaʻai: pinepine - ka nalowale o ka makemake, pinepine pinepine - hyperglycemia, loaʻa ʻole - hyponatremia, dehydration, syndrome o ka hemahema o ka huna ʻana o ADH (antidiuretic hormone),
Pūnaehana Cardiovascular: pinepine - ka hyperemia, palpitations, pinepine - hoʻonui i ke koko, nā orthostatic hypotension, tachycardia, kahiʻalulu weliweli, nāwaliwali, arrhythmia supraventricular, loaʻa pinepine iā ia - pilikia hypertensive,
Pūnaehana huhū: pinepine - ʻeha i ka oropharynx, ʻoka, ʻohi pinepine - nā wahaebleeds, he ʻāʻī o ka ʻāʻī o ka ʻāʻī,
Pūnaehana musculoskeletal: pinepine nā ʻoʻī o ka ʻiʻo, ka ʻeha o ka musculoskeletal, nā hōʻeha o ka naʻau, nā ʻōpū o ke kuʻuna o ka naʻau, ʻaʻole pinepine ka trismus,
ʻO ka ʻili a me ka ʻoliva kūloko: pinepine - iʻa, ʻeha, hoʻonaninani, ʻike pinepine ʻole - hoʻopili aku i ka dermatitis, photosensitivity, urticaria, bruising, nāwahu maloʻo, nā pāpale pō, ʻaʻohe mea maʻalahi - angioedema, Stevens-Johnson syndrome, ʻokoʻa loa - hakakā ka ʻōpū.
Pūnaehana urinary: pinepine - pinepine i ka urination, pinepine - dysuria, nocturia, nāwaliwali ka paʻakai, ʻoki ʻana i ka urinary, paʻakikī ka hoʻomaka ʻana o ka urination, ʻāua - he ʻano ʻeke ʻole o ka urine,
ʻO ke kāne a me ka momona mommary: pinepine - erectile dysfunction, infrequently - sexual dysfunction, violations of ejaculation, delay ejaculation, pain in the testicles, irregular menstruation, gynecologicalugo, ʻokoʻa - galactorrhea, hōʻailona o ka menopause, hyperprolactinemia,
Kekahi ʻōnaehana a me ka psyche: pinepine loa - ka ʻeha, ka ʻōpū, ka hopohopo, ke hiamoe nei, pinepine ka hopohopo, ke kāwele, ka ʻōpū o ka orgasm, hoʻemi i ka libido, nā moeʻuhane ʻole, nā paresthesias, nā mea haʻalulu, pinepine i hoʻonui ʻia i ka huhū, dyskinesia, hoʻemi hoʻokiʻoki i ka moe, akathisia, lethargy , ʻeha hopohopo, dysgeusia, hoʻomaha ʻeha wāwae, myoclonus, bruxism, apathy, suicidal manaʻo, disorientation, jarang psychomotor agitation, convulsions, serotonin syndrome, extrapyramidal disorders, hallucinations, suits Ka hope hana, Mania, me ka manaʻoe hōʻeha a me ka aggression,
ʻĀpana kikī: ua pinepine - tinnitus, ke anuanu blurred, pinepine - ʻike maka, mydriasis, ʻeha i ka pepeiao, vertigo, ʻike liʻiliʻi - nā maka maloʻo, glaucoma,
Pūnaehana Endocrine: līkuhi - hypothyroidism,
Pūnaehana immune: jarang - hypersensitivity, anaphylactic reaksi,
ʻO ka ʻikepili mai ka hana noiʻi a me nā mea hana: pinepine - ka hoʻohaʻahaʻa ʻana i ke kaupaona o ke kino, ka pinepine - ka hoʻonui ʻana o ke kao o ka pā paʻakai i loko o ke koko, ka hoʻonui ʻana i ka ʻai o ka bilirubin, nā proteinine phosphokinase, ka alkatine phosphatase, he transaticase hepatic a me ka gamma-glutamyl transferase, he hoʻonui nui ʻana o ke kaupaona ʻana o ka paʻakai i loko o ke koko, he piʻi iki ka ʻai ʻana o ka bilirubin, creatine phosphokinase, alkaline phosphatase, transaminases hepatic a me ka gamma-glutamyl transferase, he hoʻonui nui ʻana o ke kau ka paʻakai, a me ka hoʻoneʻe ʻana o ka naʻau o ka enzyme kolamu koko
Nā maʻi maʻi lēwa: pinepine - laryngitis,
ʻO nā maʻi maʻamau: pinepine pinepine - hoʻonui i ka momona, pinepine - he loli i ka ʻono, ke hāʻule, pinepine ʻole - ka manaʻo ʻana o ke anuanu, hōʻeha, ka ʻoluʻolu o ka wela, ka makewai, ka ʻalupā, nā hana aulima, nā ʻano hōʻeuʻeu o ka umauma, nā ʻeha ʻeha.

Me ka hikiʻole ke hoʻopau ʻia o ka lāʻau lapaʻau, i ka hapa nui o ka maʻi, ka lāʻau lapaʻau Sybalta e hoʻopuka i ka maʻi "withdrawal", kahi i hōʻike ʻia e nā ʻano ʻike e like me: ka hana kuʻuna, hoʻoweliweli, nāwaliwali, ka huhū, ka uha ʻole, hopohopo a ʻāwīwī, hōʻeha o ka hiamoe, hōʻeha, hōʻeha, ʻeha a me / a i ʻole ka luaʻi, ʻeha; vertigo a me ka hyperhidrosis.

Nā ʻōlelo kikoʻī

I ka wā o ka mālama ʻana me Simbalt i nā maʻi e loaʻa ana i ka hypertension arterial a i ʻole nā maʻi cardiovascular kekahi mea e hōʻike ʻia e mālama i ke koko.

ʻO nā mea maʻi me ka piʻi nui o ka pepehi ʻia i ka wā o ka wā lapaʻau e pono ia ma lalo o ka mākaʻi loea.

I ka wā o ka mālama ʻana, ʻōlelo ʻia ka mālama ʻana i ka wā e hana ana i nā mīkini mīkini a me ka hana ʻana me nā mea hiki ke pilikia.

Hoʻohui nūhou

ʻAʻole pono e hoʻohana ʻia ka lāʻau Simbalta i ka wā like me ka monoamine oxidase inhibitors, a ma loko hoʻi o 14 mau lā ma hope o ko lākou haʻalele ʻana ma muli o ka hopena o ka hoʻomohala ʻana i ka maʻi serotonin. Ma hope o ka hoʻokuʻu ʻana o ka hopenaxetine, ma ka liʻiliʻi loa o 5 mau lā e lohi ai ma mua o ka koho o ka papa monoamine oxidase.

Ua kuhikuhi ʻia ʻo Duloxetine me ka akahele a ma nā haʻahaʻa haʻahaʻa i ka manawa like me nā inhibitors o ka isoenzyme CYP1A2 (e.g., quinolone antibiotics), nā lāʻau lapaʻau e hoʻohuli nui ʻia e ka CYP2D6 isoenzyme system a loaʻa kahi pākole ʻoi aku ka liʻiliʻi.

Me ka hoʻokolohua ʻōpiopio me nā ʻano ʻēa a me nā mea pono o ka hana serotonergic, hiki i ka hiki ke hoʻomohala ʻia o ka maʻi serotonin.

Hoʻohana ʻia ka lāʻau lapaʻau me ka mālama i ka manawa like me ka tridlic antidepressants (amitriptyline a clomipramine), triptans a venlafaxine, tramadol, St. John's wort, tryptophan a finidine.

Me ka hoʻohana pū ʻana me nā anticoagulants a me nā lāʻau antithrombotic, hiki ke hoʻonui ʻia ka nui o ke koko, no laila, ua kuhikuhi ka hopenaxetine me kēia mau lāʻau me ka mālama.

I loko o nā mea ulaula, ua emi ka makemake o ka endxetine i loko o ka plasma e like me ka aneane 50% hoʻohālikelike ʻia me nā mea ʻole palaka.

ʻĀpana Pharmacological

Aia ʻo Simbalta i ka hui o nā antidepressants. ʻO kahi pūʻulu o ka lāʻau ka selotonin selectivein a me nā norepinephrine reuptake inhibitors. E like me ka hapa nui o nā lāʻau lapaʻau ma kēia pūʻulu, he ikaika ʻole o Symbalta i ka hōʻemi ʻana a me ka hoʻoulu hou ʻana i ka dopamine, ke kumu ka nui o nā hopena kūpono o ka lāʻau.

ʻO nā waiwai Pharmacological

No ka lilo ʻana o Symbalta i ka pūʻulu o serotonin selectivein a me nā noradrenaline reuptake inhibitors. ʻO kēia ka mea a hoʻokaʻawale mau ka lāʻau i ke komo ʻana o nā mea ʻelua wale nō mai ka wahi i ka extracellular o ka pūnao nūnū i loko o nā neurons: norepinephrine a me serotonin. Eia naʻe, e like me ka hapanui o nā ʻelele o kēia hui, pili maoli ka simbalt i ka metabolism o ka dopamine.

ʻO kēia mau mea kākau ʻekolu: serotonin, norepinephrine a me dopamine - ke kuleana no ka ʻano o ka naʻau-volitional psyche. Me ka hoʻohaʻahaʻa ʻana i ko lākou hoʻokauwī, ke kaumaha, ka hopohopo, nā pilikia hoʻoluhi a me nā ʻano like ʻole o ka naʻau a me ke ʻano. I kēia hihia, he mea nui e hoʻemi i ka neʻe ʻana ʻaʻole ma loko o nā koena, akā i loko o nā kahua ma waena o lākou.

Hoʻonui ka Symbalta i ka ʻike o nā mea hoʻopihapiha ma waena o nā ʻāpana, ke alakaʻi nei i kahi hoʻonui i loko o kā lākou synthes e nā cell me ka excretion i loko o ka intercellular space. Hāpai kēia hana i ka hoʻonuiʻana i ka mumū me ka hoʻokele hoʻonohonoho ʻana i ka lāʻau a hōʻemi i ka hopohopo.

He lālā palena iki ʻo Simbalta no ka ʻike. Kahi ʻia ke kumu o ka lāʻau lapaʻau i nā hihia aʻe:

Ke lapaʻau nei no ka hana ʻana i ka manawa kaumaha, ka hopena o ke kaumaha kaumaha,
I hoʻokahi mauʻano no ka huhū kaumaha,
ʻO ka maʻi hōʻeha o ka neuropathic hōʻeha,
ʻO nā Neuropathies i nā maʻi me ka maʻi mellitus,
ʻO ka hopohopo kaumaha.

ʻAʻole hoʻohana ʻia ʻo Simbalta i ka mālama ʻana i ke kaumaha me ke kaumaha ʻole, ʻaʻole ia i hoʻohana ʻia no ke pale ʻana i ka pohō a me ka mālama i ka insomnia. Hāʻawi ʻia nā mea maʻi me ka phobias e mālama i ka lāʻau māmā me nā lāʻau māmā. Ma keʻano holoʻokoʻa, hoʻohana ʻia ʻo Symbalta i nā hihia i loaʻa ʻole ka mālama ʻana me nā mea ʻē aʻe.

Ke keu

Ma nā hoʻokolohua hoʻokolohua, ʻaʻohe hopena ʻike lethal i nānā ʻia me kahi overdose o ka hōʻailona. ʻO ka hoʻopiʻi ʻana i nā ʻōmole i ʻōlelo ʻia i hiki ke alakaʻi i ka hoʻomohala ʻana i ka serotonin syndrome, i hele pū ʻia e nā kūlana delirious, delirium a me nā hallucinations. Eia kekahi, hiki i ka hōʻino o ka manaʻo hoʻomaopopo ke hiki i kahi coma. Hoʻomaʻa pinepine pinepine me kahi puʻupuʻu liʻiliʻi, ka hiamoe, a luaʻi a me ka piʻi ʻana o ka puʻuwai puʻuwai. I nā pilikia pinepine, hoʻomanawanui i ka maʻi maʻi.

ʻAʻohe kōkua kūikawā no ka pā overdose o simbalta. Hoʻopuka ʻia ka lāʻau detoxification.

Nā ʻōkuhi no ka hoʻohana

No nā mea hoʻonāukiuki a me nā maʻi luhi, ʻo ka nui o ka pomo therapeutic o 60 mg. Pono inu ka lāʻau i ka wā hoʻokahi i ka lā, ma ke koho i ke kakahiaka a i ke ahiahi. I ka hanana ʻana kēia hana, ʻaʻole hoʻonui ka nui o ka nui - 120 mg. I kēia hihia, ua hoʻokaʻawale ʻia ka wana i kēlā me kēia lā i ʻelua mau manawa - i ke kakahiaka a me ke ahiahi, hoʻokahi capsule. Hiki ke loiloi ka hopena o ka mālama ʻia ma hope o 8 hebedoma.

No ka hopohopo o ke kaumaha, he haʻahaʻa ka dosage hoʻomaka. I kēia hihia, ua kau ʻia ʻo Symbalta no 30 mg hoʻokahi i ka lā. I ka hihia o ka mālama ʻana, hiki ke pāpālua ka nui o ka makee, hoʻokaʻawale iā ia i ʻelua wā. Hoʻolaha, hiki iā ʻoe ke hoʻonui i ka hewa ma o kekahi 30 mg, a laila hou i ka 30 mg, hiki i kahi kiʻekiʻe o 120 mg. ʻAʻole kuhikuhi ʻia ka hoʻonui ʻia ʻana o kēia waiwai no ka loaʻa mai o nā hopena o nā ʻaoʻao. E ʻike ʻia ka hopena i manaʻo ʻia ma hope o nā hebedoma 4 o ka hoʻokele.

Hōʻalo ʻia nā Capsules me ka nui o ka wai, ʻaʻole kai a ka ʻai i ka inu ʻana i ka lāʻau.

He mau wahi liʻiliʻi wale nō nā ʻatikala e like me ka simbolalta, ua komo kēia:

Eia kekahi, aia he mau lāʻau e komo ana i ka hui o ka lāʻau lapaʻau like a me ke ʻano like o nā hana. E pili ana kēia:

ʻAʻole hoʻololi ʻia kēia mau lāʻau āpau.

Regina P.: "Ua lawe au iā Symbalt no 6 mau mahina ma ka pili ʻana i ke kaumaha koʻikoʻi. Ua kōkua mai ka lāʻau iaʻu, akā ʻaʻole koke. No ka mahina mua ua maʻi wau a ua ʻeha koʻu maʻi, ʻaʻole naʻe wau i ʻike i ka hopena o ka lāʻau lapaʻau. Ma kahi mahina he mau mahina ma hope aku, ua hala ka hopena holoʻokoʻa, a hoʻomaka ka ʻano e hoʻomaikaʻi maikaʻi. Ua mālama au iā Simbalt no 4 mau mahina a pau wau i ke kaumaha loa. "

Denis M: "Ua hoʻomaka wau e lawe iā Simbalt no ka hopohopo mau. Ua hoʻomanawanui au i ka maʻi hopohopo ākea mai ka wā kamaliʻi a ua mālama maikaʻi ʻia i ka haukapila. Lawe ʻo ia i 30 mg, ʻaʻohe hopena. I ka nui o ka nui o ka nui o ka dosage, hoʻomaka ka hopohopo i lalo, akā ke ʻano nui o nā lima a me nā wāwae, ua hoʻomaka ka nui o ke koko. Pono wau e ho'ōki i ka inu ʻana iā Simbalt a hoʻololi i kekahi lāʻau lapaʻau ʻē aʻe. "

Hōʻike ʻia e kahi psychiatrist: "Ma nā mākeke home o nā antidepressants, ʻaʻole ʻo Symbalta ka lāʻau lapaʻau kaulana loa. Hāpai ʻo ia me ka hakakā ʻoiai me nā hihia holomua o ke kaumaha, akā he nui nā lua. ʻO ka mea mua, aia ka nui o nā hopena ʻokoʻa loa i ka palena o ka lāʻau. Pono ka hoʻomanawanui e ʻike ʻia ma mua o ka loaʻa ʻana o ka lāʻau lapaʻau. Eia kekahi, pono e hoʻomaka ʻia ka hōʻailona e lawe wale i ka haukapila ma lalo o ka mālama. Ua pili kēia me ka nui o ka neʻe ʻana o ka hoʻāʻo i ka mea hoʻomalu i ka poʻe maʻi me ka pohō kaumaha. Ma ke kānāwai, makemake nā kauka i nā lāʻau palekana, ʻo ka hoʻohana ʻana i ka simbalt i ke ʻano o ka mālama ʻana. Ua kuhikuhi pinepine aku nā mākaʻi Komohana iā Symbalt. "

Lapaʻau lāʻau

ʻO Duloxetine kahi antidepressant, he serotonin a me nā norepinephrine reuptake inhibitor, a me ka dopamine uptake ua paʻa ʻole ʻia. ʻAʻole loaʻa i ka waiwai i ka pili nui no ka histaminergic, dopaminergic, adrenergic a me cholinergic receptors.

I loko o ka luhi, ua hoʻokumu ʻia ke ʻano o ka hana o ka endxetine i ka ʻohi ʻana i ka hoʻihoʻi hou ʻana o ka serotonin a me norepinephrine, no ka mea me ka noradrenergic a me ka serotonergic neurotransmission e hoʻonui i loko o ka pūnaehana o ka nūnaehana.

ʻO ka waiwai ia he ʻoihana nui e pale ai i ka ʻeha, no nā ʻeha o ka neuropathic etiology ua ʻike ʻia kēia e ka hoʻonui ʻia ʻana o ka ʻeha naʻau ʻana.

Lapaʻau lāʻau

Hoʻopili maikaʻi ʻia ʻo Duloxetine ma hope o ke kaʻina waha. Hoʻomaka ka hoʻopauʻana o 2 mau hola ma hope o ka lawe ʻana iā Simbalta. He manawa e hiki ai i C_max (ka uila o ke ʻano nui) - 6 mau hola. Kai ʻai C_max ʻAʻohe ona hopena, ʻoiai ke piʻi nei ka manawa e pono ai e hōʻea i kēia kuhikuhi a hiki i nā hola 10, e hoʻihoʻi ʻole ʻia ia i ke ʻano o kahi kūʻai (e pili ana i ka 11%).

ʻO ka nui ʻike ka laha ʻana o ka hopenaxetine ma kahi o 1640 lita. Hoʻopili maikaʻi ke ʻano me nā protein plasma (> 90%), ʻo ka nui me ka albumin a me α₁huehae ʻaila. ʻO ka pilikia mai ke palau / aʻai ʻaʻole pā i ka kiʻekiʻe o ka hoʻopaʻa ʻana i nā protein plasma.

Hoʻokomo ka Duloxetine i ka hana hoʻolaʻa ikaika, ua hōʻoki ʻia kona mau metabolites i loko o ka pāʻai. ʻO ka isoenzymes CYP2D6 a me CYP1A2 e hoʻomau i ka hoʻomohala i ʻelua mau metabolites nui - 4-hydroxyduloxetine glucuronide a me 5-hydroxy, 6-methoxyduloxetine sulfate. ʻAʻole lākou e loaʻa i ka hana pharmacological.

T_1/2 (hapa hapa-ola) o ka waiwai - 12 mau hola. ʻO ka hoʻomaʻamaʻa awelika he 101 l / h.

I nā mea maʻi me ka hana renal impaired koʻikoʻi (ma ka hopena o ka hopena o ka maikaʻi ʻole o ka renal) i hele aku ai i ka hemodialysis, nā waiwai C_max a me AUC (hōʻike i ke kīhaha) o ka hoʻonuixetine e hoʻonui ma 2 mau manawa. I kēia mau hihia, pono e noʻonoʻo i ka hiki ʻana o ka hōʻemi ʻana i ka ʻawaʻī o Simbalta.

Me nā ʻōmaʻomaʻo o ka hōʻeha o ka puʻuwai, ʻike ʻia kahi lohi i ka metabolism a me ka hoʻopā ʻana o nā mea.

Hoʻohui

Ma muli o ke kūlana o ka serotonin syndrome ʻaʻole pono e hoʻohana pono i ka lāʻau me nā mea pale MAO a me ʻelua mau pule ma hope o ka haʻalele ʻana MAO ka mea paʻa.

Hoʻohui nui me ka hiki hoʻomoʻi enehanaCYP1A2a CYP1A2 kumu e hoʻonui ai i ka ʻike o ka lāʻau.

Pono e mālama pono ʻia ka wā e hoʻohana pū ʻia me nā lāʻau ʻē aʻe e pili ana i ka ʻōnaehana nuhilua, ʻo ia hoʻi ka waipona.

I nā hanana pinepine, ʻoiai e hoʻohana pū ana me nā poʻe ʻē aʻe serotonin uptake inhibitors a nā lāʻau serotonergic hiki hiki ke hiʻohiʻona serotonin syndrome.

Hoʻohana pono ʻia ka wā e hoʻohana ai i nā Symbalts me nā lāʻau lapaʻau e hoʻoneʻe ana e ka ʻōnaehana o ka huina.CYP2D6.

Hōʻike pū me anticoagulants hiki ke hoʻonāukiuki i ka hoʻomaka ʻana o ke koko i hoʻopili ʻia me ka launa ʻana o kahi ʻano pharmacodynamic.

Hōʻikeʻike e pili ana iā Simbalt

ʻO nā hōʻike ʻana o nā kauka e pili ana iā Simbalt a me nā loiloi o Simbalt ma nā ʻaha kūkā loiloi i ka lāʻau lapaʻau ma ke ʻano he mālama mālama ʻia manaʻo ʻino a neuropathyEia nō naʻe, aia kekahi lāʻau i nā palena i hoʻohana ʻia ma muli o ke kiʻekiʻe kiʻekiʻe o "haʻalele" iho.

Simbalta, nā ʻōlelo e hoʻohana ai: ke ʻano a me ke ʻano

Hoʻomaka ʻia nā ʻōmaʻomaʻo nā manamana no ka ʻaina, a me ka ʻūlū ʻana, me ka ʻole pono ʻole i ka membic enteric.

ʻehaʻeha: ka hoʻomaka a me ka mālama mālama ʻia - 60 mg hoʻokahi i ka lā. Loaʻa ka hopena therapeutic ma hope o 2-4 mau pule o ka mālama. ʻO nā haʻawina haukaʻi e pili ana i ka hiki a me ka palekana o nā kahe ma ka laulā ma luna o 60 mg i 120 mg i kēlā me kēia lā i nā maʻi e pane ʻole ʻole ana i ka hopena mua ʻaʻole i hōʻoia i ka holomua o ke kūlana o ka mea maʻi. No ka pale i ka hoʻi hou ʻana, e noʻonoʻo ʻia e hoʻomau i ka lawe ʻana i nā Symbalts no 8-12 mau pule ma hope o ka hoʻi ʻana i ka pane i ka maʻi. ʻO nā mea maʻi me ka mōʻaukala o ke kaumaha a me ka pane maikaʻi ʻana i ka hopena duloxetine e hōʻike ʻia e lawe iā Symbalt i ke kūkaʻi o 60-120 mg i kēlā me kēia lā no ka manawa lōʻihi,
ua hopohopo nui ʻia ka maʻi kaumaha: ʻo ka nui o ka maʻi mua he 30 mg i kēlā me kēia lā, me kahi pane ʻole o ka maʻi lapaʻau, hiki iā ʻoe ke hoʻonui a hiki i 60 mg, kahi lapaʻau mālama no ka hapa nui o nā maʻi. ʻO ka paʻu mua a me ka mālama mālama ʻana i nā maʻi me ka hōʻeha hoʻohālikelike ʻana ʻo 60 mg i kēlā me kēia lā. Me ka maikaʻi o ka hoʻomau, ʻo ke piʻi ʻana o ka maʻi i 90 mg a i ʻole ka 120 mg e hōʻike ʻia e hoʻokō ai i ka pane lapaʻau i makemake ʻia. Ma hope o ka hoʻokō ʻana i ke kūlana o ka mea maʻi, pono ke hoʻomau ʻia ka mālama no ka 8-12 mau pule e pale ai i ka heʻe hou ʻana o ka maʻi. No nā mea maʻi, pono ke lawe ʻia kahi mahele mua o 30 mg no ʻelua mau pule ma mua o ka hoʻololi ʻana i 60 mg a i ʻole i kēlā me kēia lā.
ʻeha ʻeha o ka maʻi peropheral maʻi diabetes: mua a me ka mālama mālama ʻana - 60 mg hoʻokahi manawa i ka lā, inā pono, hiki ke hoʻonui ʻia. Pono e loiloi ʻia ka hopena therapeutic ma hope o 8 mau hebedoma hoʻohana maʻamau o Simbalta. I ka loaʻa ʻole o kahi pane kūpono i ka hoʻomaka ʻana o ka lāʻau, ma hope o kēia manawa o ka manawa, hiki ʻole ke hoʻomaikaʻi. Pono ke kauka e hoʻomaʻamaʻa i ka hopena lapaʻau maʻamau, ʻo kēlā me kēia 12 hebedoma,
ʻeha nā ʻeha musculoskeletal: ʻo ka mua o ka nui o ka 30 mg 1 mau manawa i ka lā no hoʻokahi pule, a laila e kuhikuhi ana ka mea maʻi i 60 mg 1 manawa i kēlā me kēia lā. ʻO ka papa lāʻau o ka mālama ʻana he 12 mau hebedoma. Hoʻoholo ʻia ka lōʻihi o ka hoʻohana lōʻihi ʻana e ka neʻe ʻana i ke kauka, ka noʻonoʻo ʻana i ka hoʻomanawanui o Simbalta a me ke ʻano lāʻau o ka mea maʻi.

In renal gagal me CC 30-80 ml / min, ʻaʻole pono ka hoʻoponopono ʻana.

Ma muli o ke kīpē o ka haʻalele ʻana i ke ʻano o ka maʻi maʻi, ʻaila ʻaila e pono ai me ka hoʻohaʻahaʻa ʻana i ka hopena o nā Symbalts i loko o 1-2 mau pule.

ʻŌpū a me ka lactation

hapai: hiki ke hoʻohana ʻia ʻo Symbalta ma lalo o ka mālama ʻana i nā maʻi lapaʻau i nā hihia kahi i ʻoi loa ai ka pōmaikaʻi o ka makuahine i ʻoi aku ka nui o ka maʻi o ka pēpē, ʻoiai ʻo ka ʻike o ka hoʻohana ʻana i ka lāʻau i loko o kēia pūʻulu o nā mea maʻi ʻaʻole maopopo.
lactation: contraindicated hui ʻia.

I ka wā e mālama ai me ka ujxetine, i ka hoʻolālā ʻana a i ka hoʻomaka ʻana o ka hāpai ʻana, pono ia e hōʻike i kāu kauka e pili ana i kēia.

ʻO ka hoʻohana ʻana i ka inhibot serotonin reuptake inhibitors i ka wā o ka hapai, ʻoiai ma nā hanana hope aʻe, hiki ke hoʻonui ʻia i ka ulu ʻana o ka hypertension pulmonary mau hou i nā keiki hou.

I nā hihia o ka hoʻohana ʻana o Simbalta e ka makuahine i kahi manawa ma hope o ka hāpai ʻana i ka mau keiki hou, ʻike ʻia kahi maʻi haʻalele, ka mea i ʻike ʻia e ka haʻalulu, hoʻokahe nui ke koko, ka ʻai ʻana i nā pilikia, ka maʻi hoʻonaninani o ka neuro-reflex excitability, convulsions, and respiratory syndrome syndrome. ʻO ka hapa nui o kēia mau pilikia ma ka hūnā ʻana i ka wā hānau.