Nā kuʻina o ka lāʻau langerin lāʻau

ʻO Langerin kekahi o nā lāʻau lapaʻau he nui i hoʻohana e mālama i ke kaʻina pili i kapa ʻia ka mellitus non-insulin-dependence. ʻO ka lāʻau lapaʻau kekahi mahele o ka pūʻulu nui o ka lāʻau lapaʻau, ka hopena nui o ka hopena i ka hōʻemi ʻana i ka pono o ka hoʻouka ʻana i ka insulin.

ʻO ke kumukūʻai o Langerin i loko o nā kīkia, ma muli o ke ʻano i koi ʻia, hiki ke hoʻonui ʻia mai hoʻokahi haneri a ʻekolu haneri rubles.

ʻO ka Langerin kahi lāʻau lapaʻau waha e hoʻohana ʻia ma ka paʻakikī o ka mālama ʻana i ka maʻi maʻi. ʻO kāna mea pono nui ka waiwai metformin. ʻO ka lāʻau lapaʻau kekahi o nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka nui a hoʻohana pinepine ʻia e hoʻōho i nā kiʻekiʻe o ke kōpaʻa koko i loko o nā maʻi maʻi maʻi.

ʻO kekahi koho i hiki i kēlā lāʻau lapaʻau ke hoʻoponopono nei i ka hihia o ka hana ʻole o nā papa i hoʻohana mua ʻia mai ka hui o ka sulfonylurea. Hoʻopili ʻia, he pilikia hoʻopōmaʻomaʻi no ka poʻe āpau me ka maʻi diabetes.

ʻO ia ke kumu, ʻae ʻia ʻo Langerin e hoʻohaʻahaʻa i ka pae o ke kō, akā ke kōkua pū i ka hoʻohaʻahaʻa lōlō o ke kaumaha o ka mea maʻi.

Ke ʻano lāʻau lapaʻau a me nā hōʻailona no ka hoʻohana ʻana

Hoʻohana ka hana o ka hana nui o ka lāʻau lapaʻau me kona hiki ke hoʻopaʻa i nā kaʻina o ka gluconeogenesis, me nā kaʻina o ka synthesis o nā waʻa momona o ka momona a me ka momona oxidation. ʻAʻole i hoʻopili ʻia ka mea ʻelima o ka papa biguanide i ka nui o ka insulin i hoʻokuʻu i ke koko, akā hoʻololi i kāna pharmacodynamics ma ka hōʻemi ʻana i ka ratio o ka inika i hoʻopaʻa ʻia a hoʻoneʻe i ka ratio o ka insulin i ka proinsulin.

ʻO kahi mea nui i ka hana o nā hana o ia mau papa ke hoʻoweliweli ʻana i ka ea o ka glucose e nā ʻuna o nā hāmeʻa.

ʻO ka hōʻailona nui no ka hoʻohana ʻana i kahi lāʻau lapaʻau ka hoʻomohala ʻana i ka maʻi diabetes-hilinaʻi i loko o kahi kanaka, ʻoi aku hoʻi me ka hanaʻole o ka meaʻai i ukali.

ʻO nā kumu waiwai nui o Langerin e loaʻa:

• Hoʻemi i ka nui o ka hemoglobinꓼ glycated
• hoʻokaʻawale i ka pale ʻana i nā insulin i nā ʻāpana a me ka holomua o ka insulin ин
• hoʻopilikia maikaʻi i ka hoʻohanohano ʻana o ka mika lipid o ka plasma koko
• hōʻemi i ka cholesterol cholesterol maikaʻi

Eia kekahi, ʻo ka hoʻohana ʻana i ka lāʻau e hiki ke hoʻopaʻa i ka paona kino.

Nā ʻōkuhi no ka hoʻohana ʻana i nā papa

Loaʻa ka lāʻau Langerin i ka pepa i pani ʻia.

Hoʻopili ʻia nā papa ma kahi ʻeke wai, kahi i hoʻopaʻa ʻia me ka foil alumini.

Hoʻokomo ʻia nā pepa i ka pahu pepa me nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i ka lāʻau lapaʻau.

Kālai ʻia ma ka noi i koi ʻia o nā lāʻau lapaʻau i hoʻohana ʻia, hiki ke kūʻai ʻia i ka lāʻau lapaʻau me ka ʻaʻa ʻana o:

1. 500 milligrams.
2. 850 milligrams.
3. Hoʻokahi pahu o ka waiwai ikaika.

ʻO ke ʻano ka lawe ʻana i nā papa he waha, i ka manawa e ʻai ai a ma hope iho. Kūkū aku ke kauka komo i ka maʻi no kēlā me kēia maʻi pākahi e pili ana i ka nui o ka maʻi. Pēlā pū kekahi lāʻau lapaʻau i hoʻoholo i ka nui o nā kauka o nā lāʻau lapaʻau i ka lā.

Hōʻike ʻo Langerin no ka hoʻohana ʻana e hoʻomaka i kahi papa lāʻau e pili ana i ka lapaʻau ʻana me kahi laʻa liʻiliʻi loa o 500 mg o ka mea ikaika. ʻO ka helu o ka nui o ka lāʻau i ka lā hiki ke lilo mai hoʻokahi a ʻekolu. Hoʻolaha, hiki ke hoʻonui ʻia ka dosage i 850 mg o ka hana ikaika i ke ao holoʻokoʻa (hoʻokahi mau manawa i ka lā). ʻO ka mālama kauka e mālama nei i ke ʻano o ka mea maʻi a ʻaʻole iʻoi aʻe ma mua o hoʻokahi pule i ka hebedoma.

Ua kuhikuhi ʻia ka lāʻau lapaʻau no ka mālama ʻana o ka maʻi i nā keiki ma mua o ʻumi makahiki o kona mau makahiki. Hoʻomaka ʻo Monotherapy me kahi maʻi o 500 mg o ka mea hana i hoʻokahi a ʻelua paha i ka lā. Ma hope o kekahi manawa, ʻae ʻia kahi hoʻonui o ka lāʻau i ka lāʻau, akā, ʻaʻole iʻoi aʻe ma mua o ʻelua maumeka i kēlā me kēia lā, i māhele ʻia i ʻelua a ʻekolu paha mau ʻano.

ʻO ka maʻamau, ʻo kahi hoʻololi i loko o ka nui o ka lāʻau lapaʻau e loaʻa ma hope o ka ʻumi a hiki i ka ʻumikumamālima mau lā ma muli o nā hopena o kahi hōʻike koko no ka pae glucose.

I kekahi mau hihia, ʻo kahi papa papaʻaina he ʻāpana o ka hui pū ʻana me nā inikini insulin.

Pono e hoʻomanaʻo ʻia o ka lawelawe pū ʻana o Langerin me ka insulin, sulfonylurea derivatives, acarbose, a ACE inhibitors i nānā ʻia e hoʻonui i ka hopena hypoglycemic o nā lāʻau lapaʻau.

I kekahi mau hihia, hiki i ke kauka hele ke kahakaha ka hoʻohana ʻana iā Langerin me nā papa o ka like like. I kēia mau lā, he nui ka nui o nā lāʻau lapaʻau, ka papa hana koʻikoʻi o ia ka metformin.

Hiki ke loli nui ke kumukūʻai o nā lāʻau lapaʻau, e pili ana i ka ʻoihana o ka mea hana lapaʻau.

He aha nā contraindications no ka hoʻohana?

Ka hewa kūpono i koho ʻia a i ʻole ʻole a hoʻokō ʻole i nā ʻōlelo hōʻike a ke kauka hele i hiki ke hoʻonāukiuki i ke ʻano o nā hana ʻino i ka wā e lawe ai i ka lāʻau.

Eia kekahi, aia nā hihia i pāpā ʻia ai ka hoʻohana ʻana o ka lāʻau lapaʻau e pili ana i ka metformin.

ʻO nā ʻōlelo no ka hoʻohana ʻana i ka lāʻau lapaʻau e hōʻike i kahi papa o nā cont contications.

ʻO nā contraindications koʻikoʻi ma ka hoʻohana ʻana o nā papa Langerin e loaʻa i kēia aʻe:

• ka hopena koʻikoʻi o ka ate a me nā hana paha, kā lākou pono
• ka waihue, komo i loko o ke ʻano maʻi pehu
• naʻau a ʻeha ʻole
• myocardial huaʻala
• kahi kūlana o kahi maʻi maʻi maʻi kūpilikiʻi a i ʻole nā ​​kūpuna
• ka hoʻomohala ʻana o ka maʻi maʻi maʻi diabetes
• i ka hiki ʻana o kēlā me kēia intolerance e hele ai i ka metformin a me ka hoʻomohala ʻana o nā hopena kūloko i ka componentꓼ
• ka nui o nā maʻi ʻeha
• ka hookeai me ka maʻi ʻaʻai a i ʻole ka hahai ʻana i kahi meaʻai ko kēlā me kēia lā i ʻoi aku ai ma mua o hoʻokahi tausani kilocaloriesꓼ
• ma mua a ma hope o ka hoʻomaʻamaʻa
• me nā hōʻeha nui hou
• ma mua a ma hope o nā maʻi diagnostics e hoʻohana nei i ka isotropes radioaktif o iodineꓼ
• ketoacidosis a me ka hoʻōho lactic.

Eia kekahi, ʻaʻole pono nā wahine e lawe i ka lāʻau lapaʻau i ka wā hāpai a me ka lactation.

Hiki i ka hopena o nā hopena ʻaoʻao ke hōʻike iā ia iho ma ka ʻāpana o nā ʻāpana āpau a me nā ʻōnaehana o ke kino o ke kanaka - ka gastrointestinal tract, metabolism, cardiovascular system, integuments ʻili. ʻO nā manaʻo maikaʻi loa e kū mai paha ma muli o ka lawe ʻana i ka lāʻau lapaʻau nā:

1. Hoʻolaha Flulence. I kekahi manawa hele ka maʻi maʻi maʻi ma ka maʻi diabetes type 2. E loli paha ka nausea ma ka luaʻi.
2. ʻŌpū ʻōpū o ka ʻōpū.
3. ʻO ka hiʻohiʻona o ka ʻaha metallic ma ka waha waha.
4. Hematopoiesis a me ka hemostasis.
5. Megaloblastic anemia.
6. Ke hoʻohaʻahaʻa nei i ke kō o ke koko ma lalo o ka pae i aloha ʻia - hypoglycemia.
7. ʻO ke ʻano o ka nāwaliwali o ke kino.
8. ʻEhaʻeha.
9. Nā maʻi haipule.
10. Nā maʻi hōʻeha.
11. ʻO ke ʻano o ka dermatitis a i ʻole ma ka ʻili.

Pono e mālama nui ʻia ka lawe ʻana ʻana iā Langerin me nā lāʻau lapaʻau ʻē aʻe. ʻO ka hoʻohana pū ʻana o nā papa me ka cymeditine i hoʻonui i ka hopena o ka waikika lactic. Hiki i ka hui pūʻana o Langerin me nā diuretics loop e hoʻomohala i ka hopena like. I kēia hihia, ʻoi aku i ka hiki ke hōʻike ʻia o ka acidosis lactic, ʻike ʻia kahi hōʻailona o ka hiki ʻole o ka renal.

Ke hoʻohana nei i ka lāʻau lapaʻau, pono ia e nānā i nā hana maʻamau o nā pēpē a hoʻoholo i ka nui o ka lactate i ka plasma ma ka liʻiliʻi he ʻelua ma ka makahiki.

Hāʻawi ʻia ka ʻikepili e pili ana i nā lāʻau lapaʻau e hoʻohana ai e mālama i ka maʻi maʻi i ka wikiō ma kēia ʻatikala.

ʻO ka wehewehe ʻana i ka lāʻau lapaʻau

Langerine - Kūloe hypoglycemic oral mai ka hui o ka biguanides (dimethylbiguanide). Hoʻopili ʻia ka hana o ka metformin me ka hiki iā ia ke kāpae i ka gluconeogenesis, me ka hoʻomohala ʻana i nā momona momona a me nā mea hoʻoneʻe o ka momona. Hoʻonui i ka paʻakikī o nā receptors peripheral i ka insulin a me ka hoʻohanaʻana i nā glucose i nā cell. ʻAʻole hoʻopilikia ka Metformin i ka nui o ka insulin i ke koko, akā hoʻololi i kāna pharmacodynamics e ka hoʻemi ʻana i ka ratio o ka lā i hoʻopaʻa ʻia i ka insulin e wehe manuahi a hoʻonui i ka pae o ka insulin i ka proinsulin.

Hoʻonohonoho ka Metformin i ka synthesis glycogen ma ka hana ʻana i ka synthetase glycogen. Hoʻonui i ka hiki o ka halihali i nā ʻano kīwili o nā membrane glucose. Hoʻopili i ka hoʻopili ʻana o ka pehu o ka glucose.

Hoʻēmi i ka pae o ka triglycerides, LDL, VLDL. Hoʻoulu ʻo Metformin i nā waiwai o fibrinolytic o ke koko ma o ke kāohi ʻana i kahi mea hoʻoneʻe i ka mea hoʻonāukiuki plasminogen.

ʻOiai ke lawe nei i ka metformin, paʻa mau ke kino o ka mea maʻi i ka hoʻomau ʻana a i ʻole ka hoʻohaʻahaʻa ʻana

Kahi papa inoa o nā kūmole

Nā manaʻo hoihoi

Pehea e koho ai i ka analog kūpono
I loko o ka pharmacology, hoʻokaʻawale pinepine nā lāʻau i nā ʻ synlelo a me nā kikowaena. Hoʻokomo ʻia i ke ʻano o nā like o nā ʻano like ʻole i ke ʻano he hopena therapeutic ma ke kino. Ke hoʻohālikelike nei nā analogs i nā lāʻau lapaʻau e pili ana i nā ʻano like ʻole, akā makemake ʻia no ka mālama ʻana o nā maʻi like.

ʻO nā ʻokoʻa ma waena o nā maʻi a me nā maʻi bacterial
Hoʻopilikia ʻia nā maʻi maʻi e nā maʻi, nā maʻi, nā fungi a me ka protozoa. ʻO ke ʻano o nā maʻi i hoʻomake ʻia e nā maʻi a me nā maʻi like ʻole. Eia nō naʻe, ka hoʻokaʻawale i ke kumu o ka maʻi i ke koho e kūpono i ke ʻano kūpono e kōkua ai i ka hoʻokē ʻana i ka malaise a ʻaʻole ʻoe e hōʻino i ke keiki.

ʻO nā maʻi āpau ke kumu o ke anuanu pinepine
ʻIke kekahi poʻe i kahi kūlana i kahi pinepine ke keiki a a lōʻihi no ka manawa anuanu. Lawe nā mākua iā ia i nā kauka, lawe i nā hoʻokolohua, lawe i nā lāʻau lapaʻau, a ma muli o ke ʻano, ua hoʻopaʻa inoa ʻia ke keiki me ke keiki e like me ka maʻi nui. ʻAʻole i ʻike ʻia nā kumu maoli o nā maʻi ʻeha pinepine.

Urology: hana maʻi urethritis chlamydial
Loaʻa pinepine ʻia Chlamydial urethritis ma ka hana o kahi urologist. Hoʻokumu ʻia e ka intracellular parasite Chlamidia trachomatis, aia nō nā waiwai o nā huakini a me nā maʻi like, ua makemake pinepine i ka antibiotic therapy regimens no ka maʻi antibacterial. Hiki iā ia ke hana i ka mumū ʻole o ka maʻi o ka urethra i nā kāne a me nā wahine.

Langerin - nā ʻōlelo aʻoaʻo no ka hoʻohana, nā kumukūʻai, nā loiloi

Hāʻawi ka ʻaoʻao i ka ʻike e pili ana i ka lāʻau Langerin - hōʻike ʻia nā ʻōlelo i ka unuhi unuhi. No ka ʻike hou aku, e kiʻi ʻoe i ka annotation hana mea hana. Kahi nā palapala kauoha no nā lāʻau lapaʻau ʻaʻole ia he kumu no ka lāʻau lapaʻau ponoʻī.

Mea Hana: Zentiva a.s (Republic of Slovak)

Nā mea waiwai
Nā helu maʻi o nā maʻi

• Mellitus non-insulin-hilinaʻi mellitus

Nā ʻoihana ʻoihana ʻo ka ʻoihana kāohi me ka lāʻau lapaʻau

• ʻAʻole i kuhikuhi ʻia. E nānā i nā ʻōlelo aʻoaʻo

Ka hana lāʻau lapaʻau
ʻĀpana Pharmacological

• ʻO ka hypoglycemic synthetic a me nā mea āpau i hui pūʻia

Hoʻokuʻu i ke ʻano o ka lāʻau Langerin

500 mg mau papa i kau ʻia me nā pōpō, blister pack 10 mau pākeke o nā pā he 6, 500 mg mau papa i hoʻohui ʻia me ka pōpō, 10 ka ʻūlū pōpō 10 mau ʻekena 10 kīpē o ka pahu pahu 3, 500 mg nā papa i hana ʻia, nā pōpō 10 mau ʻāpana o ka pepa 9, nā ʻōpala, 850 mg film-coated coated, blister pack 10 packet of cardboard 6, papa, 850 mg film coated packed pack, 850 mg film blister pack, 10 pack of cardboard pack 3, nā pālani i hoʻohui ʻia 850 mg, pack blister 10 mau kāleka pahu pahu 9, nā papa i hui ʻia me ka uhi kiʻi 1 g, blister pack 10 mau pālima o ke kāleka 1, nā papa i hoʻopuni ʻia me ka kiʻi ʻani film 1 g, nā pāpiha palau he 10 mau pālima o ka palani 3, nā papa i hoʻopuni ʻia me ka kiʻi ʻoniʻoni 1 g, blister pack 10 kāleka o ka papa pahu 9,

nā papa i hoʻopaʻa ʻia me ka uhi ʻia o nā kiʻi o 1 g, blister pack 10 maupana o ka pahu pahu 6,

Lapaʻau lāʻau

Hoʻēmi i ka hoihoi o ka glucose (ma ka ʻōpū ʻole a ma hope o ka ʻai) i ke koko a me ka pae o ka hemoglobin glycosylated, hoʻonui i ka hoʻohaʻahaʻa glucose. Hoʻemi i ka hoʻoliʻi ʻana o ka wahī i ka glucose, kona hana i loko o ka ate, potentiates sensitivity insulin i loko o nā hui peripheral (uptake glucose a me ka hoʻonui ʻia ka metabolism).

ʻAʻole i hoʻololi i ka huna ʻia o ka insulin e nā cell beta o nā mokulele pancreatic (pae ʻia e ka nui o ka insulin i loko o kahi ʻōpū ʻole a hoʻemi ʻia ka pane ʻana o ka lā i kēlā lā i kēia lā).

Hoʻonohonoho ʻo ia i ka pauku lipid o ka plasma koko i loko o nā mea maʻi me ka diabetes-mellitus non-insulin-hoʻonaninani: hoʻēmi ia i nā kiko o ka triglycerides, cholesterol a me LDL (hoʻoholo ʻia i kahi ʻōpū ʻole) a ʻaʻole e loli i nā pae o lipoproteins o nā mea ʻē aʻe. Mālama a hoʻoikaika paha i ke kaumaha o ke kino.

Lapaʻau lāʻau

Hoʻopili koke ʻia mai ka lolo. ʻO ka bioavailability piha (ma kahi ʻōpū ʻole) he 50-60%. Loaʻa ka Cmax i ka plasma ma hope o nā hola 2. ʻO kaʻai ʻana i ka haʻahaʻa o Cmax ma ka 40% a hoʻolōʻihi i ka hoʻokō ʻana ma o nā minuke 35.

ʻO ka hoʻohālikelike o ka kūlike o ka metformin i ke koko ua loaʻa i loko o 24-48 mau hola ʻaʻole iʻoi aku ma mua o 1 μg / ml. ʻO ka nui o ka hoʻoili (no kahi pākahi o 850 mg) ka (654 ± 358) l. Mālama ʻia i nā protein plasma, hiki ke hōʻuluʻulu i nā koholā salivary, ʻūpā a me nā pēpē.

Hoʻokuʻu ʻia ia e nā keiki (ka hapanui e ka neʻe tubular) i loli (90% i kēlā me kēia lā). Renal Cl - 350-550 ml / min. ʻO T1 / 2 kahi 6.2 h (plasma) a me 17,6 h (koko) (ka ʻokoʻa ke kū nei no ka hiki i ka cumulate i loko o nā ʻāpana koko ʻokoʻa).

I ka poʻe elemakule, hoʻonui lōʻihi ʻo T1 / 2 a hoʻonui nui Cmax. I ka hihia o ka hana renal impaired, hoʻoneʻe a T1 / 2 a me nā hoʻomaʻemaʻe o ka wehe.

I ka manawa mālama e ho'ōki i ka umauma.

Nā Hoʻohui

ʻO ka hypersensitivity, maʻi ʻeha, a i ʻole ke kaulike (ka hana a ka mea hana nui ma mua o 0.132 mmol / L i nā kāne a me 0.123 mmol / L i nā wahine), maʻi puʻuwai koʻikoʻi, nā kuhi me ka hypoxia (komo

puʻuwai a me ka hanu, ke kumu mākeke o myocardial infarction, kaila o ka cerebrovascular insufficiency, anemia), puʻuwai, maʻi ʻeha, nā hana ākea a me nā hōʻeha, ke kūpaʻa waiwa, ke kumu a me ka hoʻoneʻeʻana o ka metabolic acidosis, e komo pū me ka ketoacidosis maʻi me ke ʻole o ka hauā, ka mōʻaukala o ka lactic acidosis ka mālama ʻana i kahi meaʻai haʻahaʻa-ʻona (emi iho ma mua o 1000 kcal / lā), ka noiʻi me ka isotopes iodine isotopes, hapai, hānai.

Nā hopena hopena

Mai ke kaomi hana ʻana: ma ka hoʻomaka o ka papa o ka mālama - ana - anorexia, ʻehaʻeha, nausea, ka luaʻi, ka lemela, ʻeha o ka ʻōpū (hōʻemi me ka meaʻai), ka ʻaha metallic i loko o ka waha (3%).

Mai ka ʻaoʻao o ka ʻōnaehana cardiovascular a me ke koko (hematopoiesis, hemostasis): i nā hihia loaʻa - megaloblastic anemia (kahi hopena o ka malabsorption o ka vitamin B12 a me ka folic acid).

Mai ka ʻaoʻao o ka hana metabolism: hypoglycemia, i nā hihia līkeke - lactic acidosis (nāwaliwali, ke hiamoe nei, hypotension, ka bradyarrhythmia kūmau, ka maʻi hanu, ʻeha ʻeha, myalgia, hypothermia).

Mai ke kino: rash, dermatitis.

Hoʻopili pū me nā lāʻau ʻē aʻe

He palupalu ka hopena o ka metformin e ka thiazide a me nā diuretics, corticosteroids, phenothiazines, glucagon, nā hormone thyroid, estrogens, me nā ma ka ʻāpana o ka hoʻohālikelike waha, phenytoin, waikena nikotinika, sympathomimetics, calcium antagonist, isoniazid.

I loko o hoʻokahi waiʻala i loko o nā limahana olakino maikaʻi loa, ʻaʻole i loli ka nifedipine i ka hoʻopili ʻana, Cmax (20%), ʻo AUC (9%) metformin, Tmax a me T1 / 2. Hoʻonuiʻia ka hopena hypoglycemic e ka insulin, sulfonylurea derivatives, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers.

Ua hōʻike ʻia kahi hōʻike no ka hui hoʻokahi i loko o nā limahana olakino e hoʻonui nui ʻia ana e ka furosemide Cmax (ma ka 22%) a me AUC (e ka 15%) o ka metformin (me ka nui o nā loli nui i ka hana ʻana o ka metformin), hoʻoneʻe ʻo metformin i ka Cmax (ma o 31%), AUC (e ka 12) %) a me T1 / 2 (32%) o ka furosemide (me ka nui o nā loli nui i ka hoʻomaʻemaʻe ʻana o ka hulu o ka furosemide).

ʻAʻohe ʻikepili i ka wili o ka metformin a me ka furosemide me ka hoʻohana lōʻihi. Ke kuhi nei nā hua lāʻau (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren a me vancomycin) i hūnā ʻia i loko o nā pākaukau e hoʻokūkū nei i nā ʻōnaehana o ka tubular a hiki iā ia ke hoʻonui i ka Cmax o metformin e 60% me ka hoʻomanawanui lōʻihi.

Hoʻololi ʻo Cimetidine i ke kāpae ʻana o ka metformin, e hoʻonui ai i ka hopena o ka hoʻomohalaʻana i ka acidosis lactic. ʻAʻole kūpono me ka waiʻona (hoʻonui i ka piʻi o ka ulu ʻana i ka waikawa wai momona).

ʻO ka hana o Renal, ka kānalua glomerular, a me ka hoʻoliʻi koko e ʻike mau ʻia. Pono ka nānā pono ʻana e ʻike i ka pae o ka glucose koko i ka wā e hoʻohana ai i ka metformin i hui pū me ka sulfonylureas a i ʻole i ka insulin (pilikia o ka hypoglycemia).

ʻO ka hana hoʻohui me ka metformin a me ka insulin e lawe ʻia aku i loko o kahi haukapila a hiki i ka lawa ʻana o ka wai kūpono e pono ai kēlā me kēia lāʻau. I ka poʻe maʻi ma ka hoʻomau mau ʻana me ka metformin, pono ia e hoʻoholo i ka ʻikepili o ka vitamin B12 hoʻokahi i ka makahiki hoʻokahi ma muli o kahi hōʻemi o kona komo ʻana.

Pono e hoʻoholo i ka pae o ka lactate i loko o ka plasma i ka liʻiliʻi o 2 mau manawa i ka makahiki, a me ke ʻano o ka myalgia. Me ka piʻi nui o nā ʻike lactate, ua kāpae ʻia ka lāʻau lapaʻau.

Mai hoʻohana ma mua o nā hana ma loko a i loko o 2 mau lā ma hope o ke hoʻomaʻamaʻa ʻia, pēlā hoʻi i loko o 2 mau lā ma mua a ma hope o nā hoʻokolohua diagnostic (intravenous urography, angiography, etc.).

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana a me ka pōpoki

10 kamepiula - blisters (3) - nā pākeke o ke kāleka. 10 pcs. - blisters (6) - nā ʻeke pepa.

10 kamepiula - nā kāmele (9) - nā kāʻei o ke kāleka.

Ka hana lāʻau lapaʻau

ʻOiea hypoglycemic oral mai ka hui o ka biguanides (dimethylbiguanide). Hoʻopili ʻia ka hana o ka metformin me ka hiki iā ia ke kāpae i ka gluconeogenesis, me ka hoʻomohala ʻana i nā momona momona a me nā mea hoʻoneʻe o ka momona.

ʻAʻole hoʻopilikia ka Metformin i ka nui o ka insulin i ke koko, akā hoʻololi i kāna pharmacodynamics e ka hoʻemi ʻana i ka ratio o ka lā i hoʻopaʻa ʻia i ka insulin e wehe manuahi a hoʻonui i ka pae o ka insulin i ka proinsulin.

ʻO kahi pilina nui loa i ka hana o ka hana o ka metformin ka mea e hoʻoulu ai i ka uptake glucose e nā puʻupuʻu mus.

Hoʻonui ka Metformin i ka neʻe ʻana o ke koko i ka puʻuwai a hoʻomaikaʻi i ka hoʻololi ʻana o ka maʻi glucose i ka glycogen. Hoʻēmi i ka pae o ka triglycerides, LDL, VLDL. Hoʻoulu ʻo Metformin i nā waiwai o fibrinolytic o ke koko ma o ke kāohi ʻana i kahi mea hoʻoneʻe i ka mea hoʻonāukiuki plasminogen.

ʻO ka maʻi diabetes mellitus type 1 (ke hilinaʻi nei i ka insulin) - me ka pahuhopu o ka hōʻemi ʻana i ka pono o ka insulin a me ka pale ʻana i ka loaʻa o ka momona (me ka hoʻohui ʻana i ke ʻano o ka insulin).

ʻO ka maʻi diabetes mellitus type 2 (non-insulin-dependant) me ka hihia o ka pono ole o ka papa meaʻai (ʻoi aku hoʻi no ka momona).

Ka hoʻoponopono ʻia ʻana

No ka poʻe maʻi ʻaʻole i loaʻa i ka insulin, i nā lā 3 mua - 500 mg 3 mau manawa / lā a i ʻole 1 g 2 mau manawa / lā i ka wā a i ʻole ka ʻai. Mai ka lā 4 a hiki i ka lā 14 - 1 g 3 mau manawa / lā. Ma hope o ka lā 15, ua hoʻoponopono ka ʻai ʻana i ke ʻano o ka glucose i ke koko a me ka wai. ʻO ka papa mālama mālama 100 100 mg mg / lā.

Me ka hoʻohana like ʻana o ka insulin i ka maʻa o nā haʻahaʻa ma lalo o 40 mau ʻāpana / lā, ke ʻano like ka nui o ka nui o ke kumu no ka metformin, aʻo ka hopena o ka insulin e hiki hōʻemi iki ʻia (e nā lā 4-8 mau lā / i kēlā me kēia lā). Inā loaʻa ka mea maʻi ma mua o 40 mau ʻāpana / lā, a laila e hoʻohana ke hoʻohana ana i ka metformin a me kahi hoʻēmi ʻana i ka nui o ka insulin e pono ai ka mālama nui a lawe ʻia i loko o kahi haukapila.

Nā hōʻike a me nā kumukūʻai o ka lāʻau Langerin

pani ʻ -lelo ʻlelo

pani ʻ -lelo ʻlelo

pani ʻ -lelo ʻlelo

nā papa i kuʻi

sustovole papa papa

sustovole papa papa

pani ʻ -lelo ʻlelo

pani ʻ -lelo ʻlelo

pani ʻ -lelo ʻlelo

pani ʻ -lelo ʻlelo

pani ʻ -lelo ʻlelo

pale ʻia nā papa ʻoniʻoni ʻia

sustovole papa papa

sustovole papa papa

pani ʻ -lelo ʻlelo

Huina balota: 73 mau kauka.

Nā kikoʻī o nā mea pane i ke kikoʻī:

Loaʻa ka hopena

Mai ka pūnaehana hana ʻana: hiki (maʻa mau ma ka hoʻomaka ʻana o ka hana) nausea, luaʻi, kaʻaila.

Mai ka hoʻonā endocrine: hypoglycemia (ka wā i hoʻohana ʻia i nā pilala kūpono ʻole).

Mai ka ʻaoʻao o ka metabolism: i kekahi mau hihia - lactic acidosis (pono hele me ka mālama ʻana).

Mai ka ʻōnaehana hemopoietic: i kahi mau hihia - anemia megaloblastic.

Nā ʻōlelo kikoʻī

ʻAʻole ia i kuhikuhi ʻia no nā maʻiʻeha o ka maʻi, ka hoʻonāukiuki o nā maʻi maʻi a me ka maʻi maʻi, nā hōʻeha, nā maʻi ʻoiʻi kūlohelohe, a me ka hopena o ka lepo.

Mai hoʻohana ma mua o nā hana ma loko o 2 mau lā ma hope o ka hoʻomaʻamaʻa ʻana.

ʻAʻole ia e hoʻohana i ke metformin i nā mea maʻi ma luna o 60 mau makahiki o kēlā me kēia mea e hana nei i nā hana kino koʻikoʻi, kahi mea i pili ʻia me ka piʻi nui o ka hoʻomohala ʻana i ka waika lactic.

I ka wā e hoʻōla ai, pono ia e nānā i nā hana renal, ka hoʻoholo ʻana i nā ʻike o ka lactate i loko o ka plasma e lawe ʻia aku ma kahi o nā manawa 2 i ka makahiki, a me ka ʻano like o ka myalgia.

Hiki ke hoʻohana ʻia ka metformin me ka hui pū me ka olihiluna. I kēia hihia, pono e mālama pono ana i ka pae o ka glucose koko.

Hoʻohana ʻia ka hoʻohana ʻana o ka metformin ma ke ʻano he hui hoʻohui me ka insulin i ka haukapila.

Hoʻohui nūhou

Me ka hana like me ka derivatives sulfonylurea, acarbose, insulin, salicylates, MAO inhibitors, oxytetracycline, ACE inhibitors, me clofibrate, cyclophosphamide, hiki i ka hopena hypoglycemic o metformin hiki ke hoʻonui ʻia.

Me ka hana like me ka GCS, hiki i ka contraceptives hormonal no ka hoʻokūkū waha, adrenaline, glucagon, hormon thyroid, deriviazine derivatives, thiazide diuretics, derivin acid nicotinic, kahi hōʻemi i ka hopena hypoglycemic o metformin i hiki.

ʻO ka hoʻohana pinepine ʻana o ka cimetidine e hoʻonui i ka hopena o ka waikika lactic.

37. : 2.92)
Hawaii

Nā Nānā LANGERIN (LANAGERIN)

ʻĀkau ATX: A10BA02

Hoʻomaʻaʻia ka Metformin mai ka papa hana. Loaʻa ka Cmax i ka plasma i kahi kokoke i 2 mau hola ma hope o ka nānā aku. Ma hope o 6 mau hola, ʻaʻole i pau ka hoʻowalewale ʻana mai ka papa gastrointestinal a pau ka piʻi ʻana o ka metformin i loko o ka plasma e pau mau ana i loko o nā protein protein. Mālama i nā kohu salivary, ʻāpili a me nā lolo.T1 / 2 - 1.5-4.5 mau hola.ʻO ke kāpili ʻia e nā lāʻau.

E kūʻai iā LANGERINE

Buy ma ke kumu kūʻai haʻahaʻa:

Mahalo nui kā mākou mau malihini iā ​​ʻoe inā ʻoe e kākau nei i kahi lāʻau lapaʻau pūnaewele i loaʻa iā ʻoe ka hāʻawi maikaʻi loa.

Ka helu o nā malihini ma ka māka o ka "kumukūʻai / kūpono": 37. : 2.92)
Hawaii

Inā ʻoe e hoʻohana i ka lāʻau lapaʻau LANZHERIN (LANAGERIN), mai hoʻomaloka e haʻalele i kāu loiloi e pili ana i ka hoʻohana ʻana i ka lāʻau lapaʻau. E aʻo ʻia e loiloi i ka ʻōlelo ʻana iā LANGERINE ma o ka liʻiliʻi ʻelua mau ʻāpana: ke kumu kūʻai a me ka hana pono. E kōkua aku ʻoe i nā kānaka inā ʻoe e hōʻike ana i ka maʻi ka mea i loaʻa ai ka lāʻau lapaʻau.

Langerin - ka wehewehe ʻana o ka lāʻau lapaʻau, nā ʻōlelo e pili ana no ka hoʻohana ʻana, a me nā loiloi - Pūnaewele Kauka

Kākau i kahi loiloi
Nā manaʻo 1

Mea Hana: Zentiva a.s (Republic of Slovak)

Nā mea waiwai

Nā helu maʻi o nā maʻi

• Mellitus non-insulin-hilinaʻi mellitus

Nā ʻoihana ʻoihana ʻo ka ʻoihana kāohi me ka lāʻau lapaʻau

• ʻAʻole i kuhikuhi ʻia. E nānā i nā ʻōlelo aʻoaʻo

Ka hana lāʻau lapaʻau

ʻĀpana Pharmacological

• ʻO ka hypoglycemic synthetic a me nā mea āpau i hui pūʻia

Hoʻohana i ka wā hāpai

I ka wā hapai, hiki ke mālama ʻia inā ʻo ka hopena o ka hopena o ka hopena ma mua o ka hopena i ke kauā (ʻoiʻi a paʻa paʻa nā haʻawina no ka hoʻohana ʻana i ka wā hāpai ʻia ʻaʻole i mālama ʻia).

ʻO ka māhele FDA o ka hana ma ka lōkō ʻo B.

I ka manawa mālama e ho'ōki i ka umauma.

ʻO ka pilina me nā lāʻau lapaʻau ʻē aʻe

He palupalu ka hopena o ka metformin e ka thiazide a me nā diuretics, corticosteroids, phenothiazines, glucagon, nā hormone thyroid, estrogens, me nā ma ka ʻāpana o ka hoʻohālikelike waha, phenytoin, waikena nikotinika, sympathomimetics, calcium antagonist, isoniazid.

I loko o hoʻokahi waiʻala i loko o nā limahana olakino maikaʻi loa, ʻaʻole i loli ka nifedipine i ka hoʻopili ʻana, Cmax (20%), ʻo AUC (9%) metformin, Tmax a me T1 / 2.

Hoʻonuiʻia ka hopena hypoglycemic e ka insulin, sulfonylurea derivatives, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers.

Ua hōʻike ʻia kahi hōʻike no ka hui hoʻokahi i loko o nā limahana olakino e hoʻonui nui ʻia ana e ka furosemide Cmax (ma ka 22%) a me AUC (e ka 15%) o ka metformin (me ka nui o nā loli nui i ka hana ʻana o ka metformin), hoʻoneʻe ʻo metformin i ka Cmax (ma o 31%), AUC (e ka 12) %) a me T1 / 2 (32%) o ka furosemide (me ka nui o nā loli nui i ka hoʻomaʻemaʻe ʻana o ka hulu o ka furosemide). ʻAʻohe ʻikepili i ka wili o ka metformin a me ka furosemide me ka hoʻohana lōʻihi. Ke kuhi nei nā hua lāʻau (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren a me vancomycin) i hūnā ʻia i loko o nā pākaukau e hoʻokūkū nei i nā ʻōnaehana o ka tubular a hiki iā ia ke hoʻonui i ka Cmax o metformin e 60% me ka hoʻomanawanui lōʻihi. Hoʻololi ʻo Cimetidine i ke kāpae ʻana o ka metformin, e hoʻonui ai i ka hopena o ka hoʻomohalaʻana i ka acidosis lactic. ʻAʻole kūpono me ka waiʻona (hoʻonui i ka piʻi o ka ulu ʻana i ka waikawa wai momona).

Hoʻomaʻamaʻa no ka hoʻohana

ʻO ka hana o Renal, ka kānalua glomerular, a me ka hoʻoliʻi koko e ʻike mau ʻia. Pono ka nānā pono ʻana e ʻike i ka pae o ka glucose koko i ka wā e hoʻohana ai i ka metformin i hui pū me ka sulfonylureas a i ʻole i ka insulin (pilikia o ka hypoglycemia).

ʻO ka hana hoʻohui me ka metformin a me ka insulin e lawe ʻia aku i loko o kahi haukapila a hiki i ka lawa ʻana o ka wai kūpono e pono ai kēlā me kēia lāʻau. I ka poʻe maʻi ma ka hoʻomau mau ʻana me ka metformin, pono ia e hoʻoholo i ka ʻikepili o ka vitamin B12 hoʻokahi i ka makahiki hoʻokahi ma muli o kahi hōʻemi o kona komo ʻana.

Pono e hoʻoholo i ka pae o ka lactate i loko o ka plasma i ka liʻiliʻi o 2 mau manawa i ka makahiki, a me ke ʻano o ka myalgia. Me ka piʻi nui o nā ʻike lactate, ua kāpae ʻia ka lāʻau lapaʻau.

Mai hoʻohana ma mua o nā hana ma loko a i loko o 2 mau lā ma hope o ke hoʻomaʻamaʻa ʻia, pēlā hoʻi i loko o 2 mau lā ma mua a ma hope o nā hoʻokolohua diagnostic (intravenous urography, angiography, etc.).

Nā huina like:

** ʻO ke kuhikuhi ʻana i ka hana lapaʻau no nā ʻike ʻike wale nō. No ka ʻike hou aku, e kiʻi i ka annotation a nā mea hana.

Mai hoʻolaʻa ponoʻī iā ʻoe ma mua o kou hoʻomaka ʻana i ka hoʻohana ʻana iā Langerin, pono ʻoe e kamaʻilio i kahi kauka. ʻAʻole kuleana ʻo EUROLAB no ka hopena i hoʻoiho ʻia e ka ʻike o ka ʻikepili i hōʻike ʻia ma ka waihona.

ʻAʻole hoʻohuli nā ʻikepili ma ka pūnaewele i ka ʻōlelo aʻo a ke kauka a ʻaʻole hiki ke lawelawe me ka hōʻoia ʻana o ka hopena maikaʻi o ka lāʻau.

Ke makemake nei ʻoe i ka Langerin? Makemake ʻoe e ʻike i nā ʻikepili hou aʻe a makemake paha e ʻike i ke kauka? A i ʻole makemake paha ʻoe i ka hoʻokolokolo? Hiki iā ʻoe e hana me ke kauka - haukapila Eurolabepela mau i kāu lawelawe! E nānā nā kauka maikaʻi iā ʻoe, e aʻo aku, e hāʻawi i ke kōkua e pono ai a hana i kahi maʻi maʻi. Hiki iā ʻoe ke kāhea i ke kauka ma ka home. ^ E Ha yM. ʻO ka hale lapaʻau Eurolabepela wehe iā ʻoe a puni ka uaki.

** Manalo! ʻO ka ʻike i hōʻike ʻia i loko o kēia alakaʻi lāʻau i manaʻo ʻia no nā mea lapaʻau a ʻaʻole pono ia i kumu no ka lāʻau lapaʻau ponoʻī. Hāʻawi ʻia ka wehewehe ʻana o ka lāka Langerin no ka ʻike a ʻaʻole i manaʻo ʻia e kuhikuhi i ka hana me ka ʻole o ke komo ʻana i kahi kauka. Pono ka poʻe maʻi i nā ʻōlelo aʻo kikoʻi!

ʻŌpū a me ka lactation

Contraindicated ma ka hāpai ʻana a me ka lactation.

Hoʻohana no ka hana lawelawe lēwa

Contraindicated ma ka maʻi akea pāpaʻi hana paʻa.

Hoʻohana no ka hana renal impaired

Contraindicated i ka hoʻonā kino nui ʻana.

Hoʻohana i ka wā kahiko

ʻAʻole ʻōlelo ʻia ʻo Metformin no nā poʻe maʻi ma mua o 60 mau makahiki o ka makahiki, i pili ʻia me ka piʻi nui o ka lactic acidosis.

Nā ʻōlelo kikoʻī

ʻAʻole ia i kuhikuhi ʻia no nā maʻiʻeha o ka maʻi, ka hoʻonāukiuki o nā maʻi maʻi a me ka maʻi maʻi, nā hōʻeha, nā maʻi ʻoiʻi kūlohelohe, a me ka hopena o ka lepo.

Mai hoʻohana ma mua o nā hana ma loko o 2 mau lā ma hope o ka hoʻomaʻamaʻa ʻana.

ʻAʻole ia e hoʻohana i ke metformin i nā mea maʻi ma luna o 60 mau makahiki o kēlā me kēia mea e hana nei i nā hana kino koʻikoʻi, kahi mea i pili ʻia me ka piʻi nui o ka hoʻomohala ʻana i ka waika lactic.

I ka wā e hoʻōla ai, pono ia e nānā i nā hana renal, ka hoʻoholo ʻana i nā ʻike o ka lactate i loko o ka plasma e lawe ʻia aku ma kahi o nā manawa 2 i ka makahiki, a me ka ʻano like o ka myalgia.

Hiki ke hoʻohana ʻia ka metformin me ka hui pū me ka olihiluna. I kēia hihia, pono e mālama pono ana i ka pae o ka glucose koko.

Hoʻohana ʻia ka hoʻohana ʻana o ka metformin ma ke ʻano he hui hoʻohui me ka insulin i ka haukapila.

Hoʻohui nūhou

Me ka hana like me ka derivatives sulfonylurea, acarbose, insulin, salicylates, MAO inhibitors, oxytetracycline, ACE inhibitors, me clofibrate, cyclophosphamide, hiki i ka hopena hypoglycemic o metformin hiki ke hoʻonui ʻia.

Me ka hana like me ka GCS, hiki i ka contraceptives hormonal no ka hoʻokūkū waha, adrenaline, glucagon, hormon thyroid, deriviazine derivatives, thiazide diuretics, derivin acid nicotinic, kahi hōʻemi i ka hopena hypoglycemic o metformin i hiki.

ʻO ka hoʻohana pinepine ʻana o ka cimetidine e hoʻonui i ka hopena o ka waikika lactic.

37. : 2.92)
Hawaii

Nā Nānā LANGERIN (LANAGERIN)

ʻĀkau ATX: A10BA02

Hoʻomaʻaʻia ka Metformin mai ka papa hana. Loaʻa ka Cmax i ka plasma i kahi kokoke i 2 mau hola ma hope o ka nānā aku. Ma hope o 6 mau hola, ʻaʻole i pau ka hoʻowalewale ʻana mai ka papa gastrointestinal a pau ka piʻi ʻana o ka metformin i loko o ka plasma e pau mau ana i loko o nā protein protein. Mālama i nā kohu salivary, ʻāpili a me nā lolo.T1 / 2 - 1.5-4.5 mau hola.ʻO ke kāpili ʻia e nā lāʻau.

Nā ʻōkuhi no ka hoʻohana

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana a me ka pōpoki

10 kamepiula - blisters (3) - nā pākeke o ke kāleka. 10 pcs. - blisters (6) - nā pākeke o ke kāleka. 10 pcs. - nā kāmele (9) - nā kāʻei o ke kāleka.

Nā papa hana ʻoniʻoni, 850 mg: 30, 60 a 90 mau pcs. - LSR-003625/10, 04.30.10

No ka poʻe maʻi ʻaʻole i loaʻa i ka insulin, i nā lā 3 mua - 500 mg 3 mau manawa i ka lā. a i ʻole 1 g 2 mau lā i ka lā. i ka wā a i ʻole ka ʻai. Mai ka lā 4 a hiki i ka lā 14 - 1 g 3 mau manawa i ka lā. Ma hope o ka lā 15, ua hoʻoponopono ka ʻai ʻana i ke ʻano o ka glucose i ke koko a me ka wai. ʻO ka papa mālama mālama 100 100 mg mg / lā.

Me ka hoʻohana ʻana o ka insulin i kahi maʻa o kahi liʻiliʻi aʻe ma lalo o 40 mau papa / lā. ka like o ka nui o ka dosage o metformin, ʻoiai ke emi iki ka nui o ka insulin (e nā 4-8 mau pūʻulu / lā i kēlā me kēia lā). Inā loaʻa ka mea maʻi ma mua o 40 mau ʻāpana / la, a laila ka hoʻohana ʻana i ka metformin a me kahi hoʻēmi ʻana i ka nui o ka insulin e pono ai ka mālama nui a lawe ʻia i loko o kahi haukapila.

ʻŌpū a me ka lactation

Contraindicated ma ka hāpai ʻana a me ka lactation.

E kūʻai iā LANGERINE

Buy ma ke kumu kūʻai haʻahaʻa:

Mahalo nui kā mākou mau malihini iā ​​ʻoe inā ʻoe e kākau nei i kahi lāʻau lapaʻau pūnaewele i loaʻa iā ʻoe ka hāʻawi maikaʻi loa.

Ka helu o nā malihini ma ka māka o ka "kumukūʻai / kūpono": 37. : 2.92)
Hawaii

Inā ʻoe e hoʻohana i ka lāʻau lapaʻau LANZHERIN (LANAGERIN), mai hoʻomaloka e haʻalele i kāu loiloi e pili ana i ka hoʻohana ʻana i ka lāʻau lapaʻau. E aʻo ʻia e loiloi i ka ʻōlelo ʻana iā LANGERINE ma o ka liʻiliʻi ʻelua mau ʻāpana: ke kumu kūʻai a me ka hana pono. E kōkua aku ʻoe i nā kānaka inā ʻoe e hōʻike ana i ka maʻi ka mea i loaʻa ai ka lāʻau lapaʻau.

Langerin: nā loiloi e pili ana i ka lāʻau lapaʻau, kumukūʻai, nā ʻōlelo aʻoaʻo

ʻO Langerin kekahi o nā lāʻau lapaʻau he nui i hoʻohana e mālama i ke kaʻina pili i kapa ʻia ka mellitus non-insulin-dependence. ʻO ka lāʻau lapaʻau kekahi mahele o ka pūʻulu nui o ka lāʻau lapaʻau, ka hopena nui o ka hopena i ka hōʻemi ʻana i ka pono o ka hoʻouka ʻana i ka insulin.

ʻO ke kumukūʻai o Langerin i loko o nā kīkia, ma muli o ke ʻano i koi ʻia, hiki ke hoʻonui ʻia mai hoʻokahi haneri a ʻekolu haneri rubles.

ʻO ka Langerin kahi lāʻau lapaʻau waha e hoʻohana ʻia ma ka paʻakikī o ka mālama ʻana i ka maʻi maʻi. ʻO kāna mea pono nui ka waiwai metformin. ʻO ka lāʻau lapaʻau kekahi o nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka nui a hoʻohana pinepine ʻia e hoʻōho i nā kiʻekiʻe o ke kōpaʻa koko i loko o nā maʻi maʻi maʻi.

ʻO kekahi koho i hiki i kēlā lāʻau lapaʻau ke hoʻoponopono nei i ka hihia o ka hana ʻole o nā papa i hoʻohana mua ʻia mai ka hui o ka sulfonylurea. Hoʻopili ʻia, he pilikia hoʻopōmaʻomaʻi no ka poʻe āpau me ka maʻi diabetes.

ʻO ia ke kumu, ʻae ʻia ʻo Langerin e hoʻohaʻahaʻa i ka pae o ke kō, akā ke kōkua pū i ka hoʻohaʻahaʻa lōlō o ke kaumaha o ka mea maʻi.

Ke ʻano lāʻau lapaʻau a me nā hōʻailona no ka hoʻohana ʻana

Hoʻohana ka hana o ka hana nui o ka lāʻau lapaʻau me kona hiki ke hoʻopaʻa i nā kaʻina o ka gluconeogenesis, me nā kaʻina o ka synthesis o nā waʻa momona o ka momona a me ka momona oxidation.

ʻAʻole i hoʻopili ʻia ka mea ʻelima o ka papa biguanide i ka nui o ka insulin i hoʻokuʻu i ke koko, akā hoʻololi i kāna pharmacodynamics ma ka hōʻemi ʻana i ka ratio o ka inika i hoʻopaʻa ʻia a hoʻoneʻe i ka ratio o ka insulin i ka proinsulin.

ʻO kahi mea nui i ka hana o nā hana o ia mau papa ke hoʻoweliweli ʻana i ka ea o ka glucose e nā ʻuna o nā hāmeʻa.

ʻO ka hōʻailona nui no ka hoʻohana ʻana i kahi lāʻau lapaʻau ka hoʻomohala ʻana i ka maʻi diabetes-hilinaʻi i loko o kahi kanaka, ʻoi aku hoʻi me ka hanaʻole o ka meaʻai i ukali.

ʻO nā kumu waiwai nui o Langerin e loaʻa:

• Hoʻemi i ka nui o ka hemoglobinꓼ glycated
• hoʻokaʻawale i ka pale ʻana i nā insulin i nā ʻāpana a me ka holomua o ka insulin ин
• hoʻopilikia maikaʻi i ka hoʻohanohano ʻana o ka mika lipid o ka plasma koko
• hōʻemi i ka cholesterol cholesterol maikaʻi

Eia kekahi, ʻo ka hoʻohana ʻana i ka lāʻau e hiki ke hoʻopaʻa i ka paona kino.

Nā ʻōkuhi no ka hoʻohana ʻana i nā papa

Loaʻa ka lāʻau Langerin i ka pepa i pani ʻia.

Hoʻopili ʻia nā papa ma kahi ʻeke wai, kahi i hoʻopaʻa ʻia me ka foil alumini.

Hoʻokomo ʻia nā pepa i ka pahu pepa me nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i ka lāʻau lapaʻau.

Kālai ʻia ma ka noi i koi ʻia o nā lāʻau lapaʻau i hoʻohana ʻia, hiki ke kūʻai ʻia i ka lāʻau lapaʻau me ka ʻaʻa ʻana o:

1. 500 milligrams.
2. 850 milligrams.
3. Hoʻokahi pahu o ka waiwai ikaika.

ʻO ke ʻano ka lawe ʻana i nā papa he waha, i ka manawa e ʻai ai a ma hope iho. Kūkū aku ke kauka komo i ka maʻi no kēlā me kēia maʻi pākahi e pili ana i ka nui o ka maʻi. Pēlā pū kekahi lāʻau lapaʻau i hoʻoholo i ka nui o nā kauka o nā lāʻau lapaʻau i ka lā.

Hōʻike ʻo Langerin no ka hoʻohana ʻana e hoʻomaka i kahi papa lapaʻau e pili ana i ka lāʻau lapaʻau me ka hapa liʻiliʻi o 500 mg o ka mea ikaika. ʻO ka helu o ka nui o ka lāʻau i ka lā hiki ke lilo mai hoʻokahi a ʻekolu.

Hoʻolaha, hiki ke hoʻonui ʻia ka dosage i 850 mg o ka hana ikaika i ke ao holoʻokoʻa (hoʻokahi mau manawa i ka lā).

ʻO ka mālama kauka e mālama nei i ke ʻano o ka mea maʻi a ʻaʻole iʻoi aʻe ma mua o hoʻokahi pule i ka hebedoma.

Ua kuhikuhi ʻia ka lāʻau lapaʻau no ka mālama ʻana o ka maʻi i nā keiki ma mua o ʻumi makahiki o kona mau makahiki. Hoʻomaka ʻo Monotherapy me kahi maʻi o 500 mg o ka mea hana i hoʻokahi a ʻelua paha i ka lā. Ma hope o kekahi manawa, ʻae ʻia kahi hoʻonui o ka lāʻau i ka lāʻau, akā, ʻaʻole iʻoi aʻe ma mua o ʻelua maumeka i kēlā me kēia lā, i māhele ʻia i ʻelua a ʻekolu paha mau ʻano.

ʻO ka maʻamau, ʻo kahi hoʻololi i loko o ka nui o ka lāʻau lapaʻau e loaʻa ma hope o ka ʻumi a hiki i ka ʻumikumamālima mau lā ma muli o nā hopena o kahi hōʻike koko no ka pae glucose.

I kekahi mau hihia, ʻo kahi papa papaʻaina he ʻāpana o ka hui pū ʻana me nā inikini insulin.

Pono e hoʻomanaʻo ʻia o ka lawelawe pū ʻana o Langerin me ka insulin, sulfonylurea derivatives, acarbose, a ACE inhibitors i nānā ʻia e hoʻonui i ka hopena hypoglycemic o nā lāʻau lapaʻau.

I kekahi mau hihia, hiki i ke kauka hele ke kahakaha ka hoʻohana ʻana iā Langerin me nā papa o ka like like. I kēia mau lā, he nui ka nui o nā lāʻau lapaʻau, ka papa hana koʻikoʻi o ia ka metformin.

Hiki ke loli nui ke kumukūʻai o nā lāʻau lapaʻau, e pili ana i ka ʻoihana o ka mea hana lapaʻau.

He aha nā contraindications no ka hoʻohana?

Ka hewa kūpono i koho ʻia a i ʻole ʻole a hoʻokō ʻole i nā ʻōlelo hōʻike a ke kauka hele i hiki ke hoʻonāukiuki i ke ʻano o nā hana ʻino i ka wā e lawe ai i ka lāʻau.

Eia kekahi, aia nā hihia i pāpā ʻia ai ka hoʻohana ʻana o ka lāʻau lapaʻau e pili ana i ka metformin.

ʻO nā ʻōlelo no ka hoʻohana ʻana i ka lāʻau lapaʻau e hōʻike i kahi papa o nā cont contications.

ʻO nā contraindications koʻikoʻi ma ka hoʻohana ʻana o nā papa Langerin e loaʻa i kēia aʻe:

• ka hopena koʻikoʻi o ka ate a me nā hana paha, kā lākou pono
• ka waihue, komo i loko o ke ʻano maʻi pehu
• naʻau a ʻeha ʻole
• myocardial huaʻala
• kahi kūlana o kahi maʻi maʻi maʻi kūpilikiʻi a i ʻole nā ​​kūpuna
• ka hoʻomohala ʻana o ka maʻi maʻi maʻi diabetes
• i ka hiki ʻana o kēlā me kēia intolerance e hele ai i ka metformin a me ka hoʻomohala ʻana o nā hopena kūloko i ka componentꓼ
• ka nui o nā maʻi ʻeha
• ka hookeai me ka maʻi ʻaʻai a i ʻole ka hahai ʻana i kahi meaʻai ko kēlā me kēia lā i ʻoi aku ai ma mua o hoʻokahi tausani kilocaloriesꓼ
• ma mua a ma hope o ka hoʻomaʻamaʻa
• me nā hōʻeha nui hou
• ma mua a ma hope o nā maʻi diagnostics e hoʻohana nei i ka isotropes radioaktif o iodineꓼ
• ketoacidosis a me ka hoʻōho lactic.

Eia kekahi, ʻaʻole pono nā wahine e lawe i ka lāʻau lapaʻau i ka wā hāpai a me ka lactation.

Hiki i ka hopena o nā hopena ʻaoʻao ke hōʻike iā ia iho ma ka ʻāpana o nā ʻāpana āpau a me nā ʻōnaehana o ke kino o ke kanaka - ka gastrointestinal tract, metabolism, cardiovascular system, integuments ʻili. ʻO nā manaʻo maikaʻi loa e kū mai paha ma muli o ka lawe ʻana i ka lāʻau lapaʻau nā:

1. Hoʻolaha Flulence. I kekahi manawa hele ka maʻi maʻi maʻi ma ka maʻi diabetes type 2. E loli paha ka nausea ma ka luaʻi.
2. ʻŌpū ʻōpū o ka ʻōpū.
3. ʻO ka hiʻohiʻona o ka ʻaha metallic ma ka waha waha.
4. Hematopoiesis a me ka hemostasis.
5. Megaloblastic anemia.
6. Ke hoʻohaʻahaʻa nei i ke kō o ke koko ma lalo o ka pae i aloha ʻia - hypoglycemia.
7. ʻO ke ʻano o ka nāwaliwali o ke kino.
8. ʻEhaʻeha.
9. Nā maʻi haipule.
10. Nā maʻi hōʻeha.
11. ʻO ke ʻano o ka dermatitis a i ʻole ma ka ʻili.

Pono e mālama nui ʻia ka lawe ʻana ʻana iā Langerin me nā lāʻau lapaʻau ʻē aʻe. ʻO ka hoʻohana pū ʻana o nā papa me ka cymeditine i hoʻonui i ka hopena o ka waikika lactic. Hiki i ka hui pūʻana o Langerin me nā diuretics loop e hoʻomohala i ka hopena like. I kēia hihia, ʻoi aku i ka hiki ke hōʻike ʻia o ka acidosis lactic, ʻike ʻia kahi hōʻailona o ka hiki ʻole o ka renal.

Ke hoʻohana nei i ka lāʻau lapaʻau, pono ia e nānā i nā hana maʻamau o nā pēpē a hoʻoholo i ka nui o ka lactate i ka plasma ma ka liʻiliʻi he ʻelua ma ka makahiki.

Hāʻawi ʻia ka ʻikepili e pili ana i nā lāʻau lapaʻau e hoʻohana ai e mālama i ka maʻi maʻi i ka wikiō ma kēia ʻatikala.

E wehewehe i kāu holi a koho ʻole paha i kahi kāne no nā loiloi: Huli ʻia, ʻaʻole i loaʻa.

Langerin - ka wehewehe ʻana o ka lāʻau lapaʻau, nā ʻōlelo e pili ana no ka hoʻohana ʻana, a me nā loiloi - Pūnaewele Kauka

Kākau i kahi loiloi
Nā manaʻo 1

Mea Hana: Zentiva a.s (Republic of Slovak)

Nā mea waiwai

Nā helu maʻi o nā maʻi

• Mellitus non-insulin-hilinaʻi mellitus

Nā ʻoihana ʻoihana ʻo ka ʻoihana kāohi me ka lāʻau lapaʻau

• ʻAʻole i kuhikuhi ʻia. E nānā i nā ʻōlelo aʻoaʻo

Ka hana lāʻau lapaʻau

ʻĀpana Pharmacological

• ʻO ka hypoglycemic synthetic a me nā mea āpau i hui pūʻia

Nā papaha Oral Langerin (Lanagerin)

Nā ʻōkuhi no ka hoʻohana lāʻau olakino

Nā hōʻailona no ka hoʻohana ʻana

ʻO ka maʻi diabetes mellitus type 2 (ʻoi aku paha i nā hihia i hele pū me ka obesity) me ka nānāʻole o ka hoʻoponopono ʻana o ka hyperglycemia me ka hoʻoulu ʻana i ka meaʻai, me ka i ka hui pū ʻana me ka mākaukau sulfonylurea.

E hoʻokuʻu i ke ʻano

500 mg mau papa i kau ʻia me nā pōpō, blister pack 10 mau pākeke o nā pā he 6, 500 mg mau papa i hoʻohui ʻia me ka pōpō, 10 ka ʻūlū pōpō 10 mau ʻekena 10 kīpē o ka pahu pahu 3, 500 mg nā papa i hana ʻia, nā pōpō 10 mau ʻāpana o ka pepa 9, nā ʻōpala, 850 mg film-coated coated, blister pack 10 packet of cardboard 6, papa, 850 mg film coated packed pack, 850 mg film blister pack, 10 pack of cardboard pack 3, nā pālani i hoʻohui ʻia 850 mg, pack blister 10 mau kāleka pahu pahu 9, nā papa i hui ʻia me ka uhi kiʻi 1 g, blister pack 10 mau pālima o ke kāleka 1, nā papa i hoʻopuni ʻia me ka kiʻi ʻani film 1 g, nā pāpiha palau he 10 mau pālima o ka palani 3, nā papa i hoʻopuni ʻia me ka kiʻi ʻoniʻoni 1 g, blister pack 10 kāleka o ka papa pahu 9,

nā papa i hoʻopaʻa ʻia me ka uhi ʻia o nā kiʻi o 1 g, blister pack 10 maupana o ka pahu pahu 6,

Hoʻohana i ka wā hāpai

I ka wā hapai, hiki ke mālama ʻia inā ʻo ka hopena o ka hopena o ka hopena ma mua o ka hopena i ke kauā (ʻoiʻi a paʻa paʻa nā haʻawina no ka hoʻohana ʻana i ka wā hāpai ʻia ʻaʻole i mālama ʻia).

ʻO ka māhele FDA o ka hana ma ka lōkō ʻo B.

I ka manawa mālama e ho'ōki i ka umauma.

ʻO ka pilina me nā lāʻau lapaʻau ʻē aʻe

He palupalu ka hopena o ka metformin e ka thiazide a me nā diuretics, corticosteroids, phenothiazines, glucagon, nā hormone thyroid, estrogens, me nā ma ka ʻāpana o ka hoʻohālikelike waha, phenytoin, waikena nikotinika, sympathomimetics, calcium antagonist, isoniazid.

I loko o hoʻokahi waiʻala i loko o nā limahana olakino maikaʻi loa, ʻaʻole i loli ka nifedipine i ka hoʻopili ʻana, Cmax (20%), ʻo AUC (9%) metformin, Tmax a me T1 / 2.

Hoʻonuiʻia ka hopena hypoglycemic e ka insulin, sulfonylurea derivatives, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers.

Ua hōʻike ʻia kahi hōʻike no ka hui hoʻokahi i loko o nā limahana olakino e hoʻonui nui ʻia ana e ka furosemide Cmax (ma ka 22%) a me AUC (e ka 15%) o ka metformin (me ka nui o nā loli nui i ka hana ʻana o ka metformin), hoʻoneʻe ʻo metformin i ka Cmax (ma o 31%), AUC (e ka 12) %) a me T1 / 2 (32%) o ka furosemide (me ka nui o nā loli nui i ka hoʻomaʻemaʻe ʻana o ka hulu o ka furosemide). ʻAʻohe ʻikepili i ka wili o ka metformin a me ka furosemide me ka hoʻohana lōʻihi. Ke kuhi nei nā hua lāʻau (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren a me vancomycin) i hūnā ʻia i loko o nā pākaukau e hoʻokūkū nei i nā ʻōnaehana o ka tubular a hiki iā ia ke hoʻonui i ka Cmax o metformin e 60% me ka hoʻomanawanui lōʻihi. Hoʻololi ʻo Cimetidine i ke kāpae ʻana o ka metformin, e hoʻonui ai i ka hopena o ka hoʻomohalaʻana i ka acidosis lactic. ʻAʻole kūpono me ka waiʻona (hoʻonui i ka piʻi o ka ulu ʻana i ka waikawa wai momona).

Hoʻomaʻamaʻa no ka hoʻohana

ʻO ka hana o Renal, ka kānalua glomerular, a me ka hoʻoliʻi koko e ʻike mau ʻia. Pono ka nānā pono ʻana e ʻike i ka pae o ka glucose koko i ka wā e hoʻohana ai i ka metformin i hui pū me ka sulfonylureas a i ʻole i ka insulin (pilikia o ka hypoglycemia).

ʻO ka hana hoʻohui me ka metformin a me ka insulin e lawe ʻia aku i loko o kahi haukapila a hiki i ka lawa ʻana o ka wai kūpono e pono ai kēlā me kēia lāʻau.I ka poʻe maʻi ma ka hoʻomau mau ʻana me ka metformin, pono ia e hoʻoholo i ka ʻikepili o ka vitamin B12 hoʻokahi i ka makahiki hoʻokahi ma muli o kahi hōʻemi o kona komo ʻana.

Pono e hoʻoholo i ka pae o ka lactate i loko o ka plasma i ka liʻiliʻi o 2 mau manawa i ka makahiki, a me ke ʻano o ka myalgia. Me ka piʻi nui o nā ʻike lactate, ua kāpae ʻia ka lāʻau lapaʻau.

Mai hoʻohana ma mua o nā hana ma loko a i loko o 2 mau lā ma hope o ke hoʻomaʻamaʻa ʻia, pēlā hoʻi i loko o 2 mau lā ma mua a ma hope o nā hoʻokolohua diagnostic (intravenous urography, angiography, etc.).

Ka pili ʻana i ka papa ʻōlelo ATX:

ʻO kahi hui Digestive a me ka metabolism

A10 He lāʻau lapaʻau no ka maʻi maʻi

ʻO nā lāʻau lapaʻau A10B Oral hypoglycemic

Nā huina like:

** ʻO ke kuhikuhi ʻana i ka hana lapaʻau no nā ʻike ʻike wale nō. No ka ʻike hou aku, e kiʻi i ka annotation a nā mea hana.

Mai hoʻolaʻa ponoʻī iā ʻoe ma mua o kou hoʻomaka ʻana i ka hoʻohana ʻana iā Langerin, pono ʻoe e kamaʻilio i kahi kauka. ʻAʻole kuleana ʻo EUROLAB no ka hopena i hoʻoiho ʻia e ka ʻike o ka ʻikepili i hōʻike ʻia ma ka waihona.

ʻAʻole hoʻohuli nā ʻikepili ma ka pūnaewele i ka ʻōlelo aʻo a ke kauka a ʻaʻole hiki ke lawelawe me ka hōʻoia ʻana o ka hopena maikaʻi o ka lāʻau.

Ke makemake nei ʻoe i ka Langerin? Makemake ʻoe e ʻike i nā ʻikepili hou aʻe a makemake paha e ʻike i ke kauka? A i ʻole makemake paha ʻoe i ka hoʻokolokolo? Hiki iā ʻoe e hana me ke kauka - haukapila Eurolabepela mau i kāu lawelawe! E nānā nā kauka maikaʻi iā ʻoe, e aʻo aku, e hāʻawi i ke kōkua e pono ai a hana i kahi maʻi maʻi. Hiki iā ʻoe ke kāhea i ke kauka ma ka home. ^ E Ha yM. ʻO ka hale lapaʻau Eurolabepela wehe iā ʻoe a puni ka uaki.

** Manalo! ʻO ka ʻike i hōʻike ʻia i loko o kēia alakaʻi lāʻau i manaʻo ʻia no nā mea lapaʻau a ʻaʻole pono ia i kumu no ka lāʻau lapaʻau ponoʻī. Hāʻawi ʻia ka wehewehe ʻana o ka lāka Langerin no ka ʻike a ʻaʻole i manaʻo ʻia e kuhikuhi i ka hana me ka ʻole o ke komo ʻana i kahi kauka. Pono ka poʻe maʻi i nā ʻōlelo aʻo kikoʻi!

ʻO ke ʻano waiwai

- metformin hydrochloride (metformin)

ʻŌpū a me ka lactation

ʻO ka lawa ʻana a ʻike paʻa ʻia nā haʻawina e pili ana i ka palekana o ka metformin i ka wā hāpai ʻana ʻaʻole i mālama ʻia. Hiki ke hoʻohana ʻia i ka wā hāpai a hiki i nā pilikia hōʻeha, ke loaʻa ka hopena i manaʻo ʻia no ka ʻoihana no ka makuahine ma mua o ka pūpū. Hoʻopau ka Metformin i ka pale papalua.

ʻO Metformin i loko o kahi liʻiliʻi ka mea i hoʻopihapiha ʻia i loko o ka waiū umauma, aʻo ka hoʻokūkū o ka metformin i loko o ka waiū umauma hiki ke 1/3 o ke kūpaʻa ʻana i ka plasma o ka makuahine. Hoʻokomo ʻia nā hopena i nā keiki hou i ka wā o ka wā o ka ʻōpū o ka wā e lawe ai i metformin

Eia naʻe, ma muli o ka nui o ka waiwai o ka ʻikepili, ʻaʻole i ʻōlelo ʻia ka hoʻohana i ka wā o ka hoʻoulu ʻana.

ʻO ka hoʻoholo e pani i ka hōʻuluʻulu ʻana e pono e mālama i nā pono o ka umauma a me ka hiki o nā hopena kūpono i nā hopena kūpono i ka pēpē.

Ua hōʻike ʻia nā haʻawina preclinical i ka metformin ʻaʻole i loaʻa nā hopena teratogenic i nā pona i ko 2-3 mau manawa iʻoi aku ma mua o nā dosis therapeutic i hoʻohana ʻia e nā kānaka. ʻAʻohe o Metformin i kahi puʻuwai mutagenic, ʻaʻole pili i ka huaʻai.