Movoglen® (Movogleken)

E hoʻonohonoho pono i kēlā me kēia kiʻi i ke kiʻi o ka maʻi maʻi. ʻO ka inumua mua o Movoglechen he 2.5-5 mg 1 mau manawa / lā 15-30 mau minuke ma mua o ka ʻaina kakahiaka. Inā kūpono, hiki i ke ʻano neʻe lohi (me kekahi mau manawa) i hoʻonui ʻia e 2.5-5 mg / lā. ʻO nā memona o kēlā me kēia lā i kahi o 15 mg e pono e hoʻokaʻawale i 2 mau pona.

ʻO nā dosis nui o Movoglechen: kū hoʻokahi - 15 mg, i kēlā me kēia lā - 40 mg.

Ka hana lāʻau lapaʻau

ʻO ka moliki hypoglycemic Oral, kahi derony o ka sulfonylurea o ka lua o ka hanauna. Hoʻāla i ka mea huna o ka insulin e nā β-cells o ka pancreas, hoʻonui i ka hoʻokuʻu i ka insulin. Hoʻonui i ka paʻakikī o nā kōpili peripheral i insulin. Loaʻa iā ia kahi hypolipidemic, ka hopena fibrinolytic, ke kāohi nei i ka pākuʻi platelet.

Nā hopena hopena

Mai ka ʻoihana endocrine: līkeke - hypoglycemia (ʻoi aku paha i nā poʻe ʻelemakule, nā nāwaliwali nāwaliwali, me ka ʻai maʻamau, inu i ka wai, ʻoluʻolu a me ka hana ʻana o ka pēpē).

Mai ka papa hana o ka kūnaʻi ʻana: ka nausea, ka maʻi maʻamau, ʻeha loa - maʻi hepatitis.

Mai ka pūnaehana hemopoietic: i kekahi mau hihia - thrombocytopenia, leukopenia, agranulocytosis.

He maʻi kūloko: ʻaʻole - paʻakikī ka ʻili, kaʻeha.

Nā ʻōlelo kikoʻī

I ka hoʻohana ʻana iā Movoglechen ma hope o ka insulin a me nā mea āpau hypoglycemic ʻē aʻe, pono e noʻonoʻo pono ka hoʻonui ʻana o Movoglechen i ke koko a i ka 4-5 mau lā mua e pono ai e hoʻopaʻa ʻia ka lāʻau ma muli o ka ʻōlelo glycemic.

Me ka hoʻomohala ʻana o ka hypoglycemia, inā ua ʻike ka mea maʻi, ua hoʻokaʻina (a i ʻole kahi hoʻoponopono o ke kō) paha i loko. I ka hihia o ka nalowale o ka ʻike, intravenous glucose a i ʻole glucagon sc, intramuscularly a i ʻole intravenously e lawelawe. Ma hope o ka loaʻa hou ʻana i ka naʻauao, pono e hāʻawi i ka mea maʻi i ka momona o ka mea laʻa i mea e pale ai i ka hoʻomohala hou ʻana o ka hypoglycemia.

Me nā mea hōʻeha, nā maʻi hōʻeha, ka nui loa o nā mea hoʻoponopono maʻi, e neʻe ka mea maʻi i ka hoʻohana ʻana i ka insulin.

Hoʻohui

ʻAʻole hiki ke hoʻohana ʻia ʻo Movoglechen i ka manawa like me ka miconazole.

Me ka hoʻohana pū ʻana me salicylates, sulfonamides, ACE inhibitors, ʻāpono inu waipuna, kahi hopena hypoglycemic koʻikoʻi e ulu. Hiki i ka hoʻohana pinepine ʻana i nā beta-blockers ke uhi i nā hōʻike o ka hypoglycemia.

Thiazide diuretics, progestins synthetic, GCS (me nā noi topical), hoʻohaʻahaʻa i chlorpromazine ka hana a Movoglechen.

ʻĀpana Pharmacological

Waiho i kāu manaʻo

Nā ʻIke Kūlana Kūlana, ‰

Nā palapala kākau inoa Movogleken ®

• LP-001191

ʻO ka pūnaewele mana o ka hui RLS ®. ʻO ka hoʻolaha nui o nā lāʻau lapaʻau a me nā huahana o ke kākāʻā o ka mea kūʻai aku i ka Pūnaewele Lūkia. Hāʻawi ka hua'ōlelo o Rlsnet.ru i nā mea hoʻohana me ke komo i nā ʻōkuhi, nā kumukūʻai a me nā wehewehe o nā lāʻau lapaʻau, nā mea hoʻoulu ai i nā meaʻai, nā pono olakino, nā lāʻau lapaʻau a me nā mea'ē aʻe. Hoʻokomo ka papa kuhikuhi i ka lāʻau lapaʻau e pili ana i ka ʻike a me ka puka o ka hoʻokuʻu, ka hana a ka lāʻau lapaʻau, ʻike mau no ka hoʻohana ʻana, contraindications, ka hopena o ka hopena, ka hoʻopili o ka lāʻau, nā ʻano hana o nā lāʻau lapaʻau, nā lāʻau lapaʻau. Aia i ka papa kuhikuhi ka lāʻau lapaʻau nā kumukūʻai no nā lāʻau a me nā huahana lāʻau lapaʻau ma Moscow a me nā kūlanakauhale Lūkini.

Ua pāpā ʻia ʻo ka hoʻoili ʻana, kope, hoʻoheheʻe ʻia ka ʻike me ka ʻole i ʻae ʻia ʻo RLS-Patent LLC.
I ka helu ʻana i nā ʻike ʻike i paʻi ʻia ma nā ʻaoʻao o ka pūnaewele www.rlsnet.ru, pono kahi loulou i ke kumu o ka ʻike.

ʻOi aku nā mea hoihoi aʻe

Iwai a aie ke dttla.

ʻAʻole ʻae ʻia ka hoʻohana ʻana i nā ʻoihana.

ʻO ka ʻike e hana no nā lāʻau lapaʻau.

Hoʻohui Movoglechen i ka palapala papa

Mea waiwai: keloli - 5 mg,

nā mea hoʻowalewale: lactose 130 mg, hoʻōki pregelatinized 30 mg, cellulose microcrystalline 30 mg, hypromellose (hydroxypropyl methylcellulose) 0.8 mg, waikawa stearic 1,6 mg.

cylindrical round tablet o ke keʻokeʻo keʻokeʻo me ke kahakaha "U" i loko o ka pōʻai ma kekahi ʻaoʻao a me kahi weliweli ma kekahi.

ʻO ka Pharmacodynamics o ka lāʻau

Loaʻa i ka Glipizide ka hopena o ka pancreatic a me ka extrapancreatic hopena. Hoʻonohonoho ia i ka hana huna insulin ma ka hoʻohaʻahaʻa ʻana i ka paepae beta-cell glucose pancreatic, hoʻonui i ka ʻike ʻana i ka insulin a me kona paa ʻana i nā cell target, hoʻonui i ka hoʻokuʻu ʻana i ka insulin, e hoʻonui ana i ka hana o ka insulin ma ka ʻāʻī a me ka puʻuwai glucose uptake, a pale i ka lipolysis ma ka adipose tissue. ʻO ka hōʻeha o ka hopena hypoglycemic hilinaʻi i ka nui o nā hana beta cells. He ona hypolipidemic hoʻi, ka hopena fibrinolytic, ke pale aku i ka hoonui pākuʻina, a me kāna hopena diuretic.

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua wikiwiki ka glipizide a paʻa loa i loko o ke kaaka o ka ʻōpū o ke kanaka. Loaʻa ka hoʻokūkū plasma nui loa i nā hola 1-3 ma hope o ka lawe ʻana i hoʻokahi keneka. ʻAʻole ʻai i ka ʻai i ka hopohopo holoʻokoʻa a me ka hōʻiliʻili o ka lāʻau, akā naʻe, hoʻonui ka manawa i ka manawa e hoʻoulu ʻia e 40 mau minuke. ʻO Bioavailability o 90%, ʻo ka pilina me nā protein plasma he 98-99%.

Hoʻomau ia i ka puʻuwai e hana i ka metabolites kaohi. Hoʻokuʻu ʻia ia ma nā pōpoki - 90% i ke ʻano o nā metabolites, 10 % - i loli ʻole.

ʻO ka hapalua hapalua he 2-4 mau hola.

Nā Contovications Movoglechen ma ke ʻano papa

epersensitivity a sulfonylureas, sulfonamides,

hypersensitivity no glipizide a i ʻole kekahi o nā mea pono o ka lāʻau,

maʻi diabetes type 1

maʻi ketoacidosis maʻi, maʻi kanesa precoma a me ka coma,

mau kūlana e koi ai i ka ʻomoʻana o ka insulin (ke puhi nui, ka nui o ka hōʻoki ʻana, nā hōʻeha hōʻeha a me nā maʻi maʻi maʻi).

hopohopo nui a me ka hana pohihihi,

lactase nele, lactose intolerance, glucose-galactose malabsorption,

hapai, lactation.

ʻO ka pane a me ke kāʻei o Movoglechen i ke ʻano papa

Loko ka ʻōiwi i ka makahiki, ke ʻano o ka maʻi maʻamau, ke koʻokoʻo o ka glucose i ke koko ma ka ʻōpū ʻole a me 2 mau hola ma hope o ka ʻai.

Hāʻawi i loko, 30 mau minuke ma mua o ka papaʻaina. ʻO ka maʻa mua o kēlā me kēia lā he 5 mg ma mua o ka ʻaina kakahiaka, inā ʻaʻohe hopena, hoʻonui ʻia ke ʻano e ka 2.5-5 mg me ka mālama mau ʻana i ka kaohi koko koko.

I nā maʻi o ka ate, nā pēpē a me nā poʻe maʻi maʻi, ʻo ka helu mua o kēlā me kēia lā he 2.5 mg.

ʻO ka 100 mg nui loa he 15 mg, ka nui o ka nui o kēlā me kēia lā he 40 mg. ʻO ka alapine o ka noho ʻana 1 ka manawa i kēlā me kēia lā, nā ʻāpana o kēlā me kēia lā he nui o ka 15 mg e hoʻokaʻawale i nā ʻāpana he 2.

Nā ʻāpana ʻaoʻao o ka lāʻau lapaʻau

Mai ka hoʻonā endocrine: hypoglycemia, hypoglycemic coma.

Mai ka ʻōnaehana hoʻonāukiuki: ʻeha, kele, hōʻeha.

Ma ka ʻāpana o ka ʻili. lapalapa i ka ʻili a me nā membuses mucous, kaʻili o ka ʻili, urticaria, eczema, photosensitivity.

Mai nā ʻekopa hemopoietic: ka pale ʻana i ka hematopoiesis sums bone (anemia, komo aplastic a me hemolytic, pancytopenia, leukopenia, agranulocytosis, thrombocytopenia).

Mai ka pūnaehana hana ʻana: nausea, luaʻi, maʻi a i ʻole constipation, flatulence, jaundice cholestatic, hōʻeha ate, hepatitis, ʻōpū porphyria, hepatic porphyria.

Mai nā hui kuʻuna: ʻike maka i nā manaʻo, ʻike maka.

Nā hōʻailona kuhikuhi: hoʻonui hana o aspartate aminotransferase (ACT), dehydrogenase lactate (LDH), phosphatase alkali (ALP), hoʻonui i ka urea nitrogen i ka plasma koko, hypercreatininemia.

Nā ʻili: nāpaona momona, myalgia, convulsions, hyponatremia, disulfiram-like reaction.

Mai ka palaki kuʻekuʻe: nausea, luaʻi, constipation, ʻeha ʻana, ʻeha o ka epigastric, hepatitis.

Ma ka ʻāpana o ka ʻili. hāhū urticaria, ʻehaʻeha o ka ʻili, erythema multiforme exudative.

Mai nā ʻekopa hemopoietic: anemia, aplastic a me hemolytic anemia, pancytopenia, leukopenia, agranulocytosis, eosinophilia, thrombocytopenia.

Nā ʻili: ʻOi paha ka hoʻomohala ʻana o ka hyponatremia a me ka ʻike pohō o ka hormone antidiuretic.

Ke keu

ʻO kahi overdose o ka lāʻau hiki ke alakaʻi i ka hoʻomohalaʻana o ka hypoglycemia.

Nā hōʻailona o ka hypoglycemia: pōloli, māhuahua palupalu, nāwaliwali ikaika, nā palpitations haʻalulu, hopohopo, hōʻeha, kaomi, ka huhū, ke kaumaha, ka ʻōlelo a me ka ʻike, paʻakikī ka hoʻohuihui, ʻike ʻole ʻia, hypoglycemic coma.

Lāʻau: inā ua ʻike ka mea maʻi, e lawe i ka glucose a me ke kō i loko, inā i ka nalo o ka ʻike, pono nui ka lawelawe ʻana o ka intravenous 40 % nā kūmole dextrose (glucose), a laila - infusion o 5% hopena dextrose, 1-2 mg o glucagon subcutaneously, intramuscularly a i ʻole intravenously. Ma hope o ka ʻike hou ʻana, pono e hāʻawi i ka mea ʻai i ka mea maʻi i ka momona hoʻokaʻawale ʻia (i mea e pale ʻole ai ka hana hou o ka hypoglycemia). Me ka edema cerebral, mannitol a me dexamethasone.

E hoʻokuʻu i ke ʻano, ka pale a me ka hoʻonohonoho

ʻO nā papa cylindrical lapalapa keʻokeʻo me ke kahakaha "U" i loko o ka pōʻai ma kekahi ʻaoʻao a me kahi weliweli ma ka ʻaoʻao.

Nā mea kūʻai: lactose 130 mg, kāpena pregelatinized 30 mg, cellulose microcrystalline 30 mg, hypromellose (hydroxypropyl methylcellulose) 0.8 mg, waikawa stearic 1,6 mg.

24 pcs. - nā laka i hana ʻia mai ka PVC / alumini foil (2) - nā pā kāleka.

Ka hoʻoponopono ʻia ʻana

E hoʻonohonoho pono i kēlā me kēia kiʻi i ke kiʻi o ka maʻi maʻi. ʻO ka helu mua ma 2.5-5 mg 1 mau lā / lā 15-30 mau minuke ma mua o ka ʻaina kakahiaka. Inā kūpono, hiki i ke ʻano neʻe lohi (me kekahi mau manawa) i hoʻonui ʻia e 2.5-5 mg / lā. ʻO nā memona o kēlā me kēia lā i kahi o 15 mg e pono e hoʻokaʻawale i 2 mau pona.

Nā kaha kūoʻo: hoʻokahi - 15 mg, lā - 40 mg.

Loaʻa ka hopena

Mai ka ʻoihana endocrine: līkeke - hypoglycemia (ʻoi aku paha i nā poʻe ʻelemakule, nā nāwaliwali nāwaliwali, me ka ʻai maʻamau, inu i ka wai, ʻoluʻolu a me ka hana ʻana o ka pēpē).

Mai ka papa hana o ka kūnaʻi ʻana: ka nausea, ka maʻi maʻamau, ʻeha loa - maʻi hepatitis.

Mai ka pūnaehana hemopoietic: i kekahi mau hihia - thrombocytopenia, leukopenia, agranulocytosis.

He maʻi kūloko: ʻaʻole - paʻakikī ka ʻili, kaʻeha.

Nā ʻokoʻa: pilikia.

Hoʻohui nūhou

Me ka hoʻohana pū ʻana me salicylates, sulfonamides, ACE inhibitors, ʻāpono inu waipuna, kahi hopena hypoglycemic koʻikoʻi e ulu. Hiki i ka hoʻohana pinepine ʻana i nā beta-blockers ke uhi i nā hōʻike o ka hypoglycemia.

ʻO ka diuret Thiazide, progestins synthetic, GCS (me ka noi topical), hōʻemi ʻia ka chlorpromazine i ka hopena o ka glipizide.

Nā huina like:

• Guarem (Guarem) Nā pahu uila i hana ʻia
• Nā papa ʻarylelo Amaryl
• Kūleʻa Viktoza (Victoza) no ka maʻi maʻi
• I ka metformin hydrochloride (Metformin hydrochlor> Mālama-Powder
• Metformin-Teva (Metformin-Teva) pākuʻi waha
• Nā Palapala Galvus Met (Galvus Met) nā papa ʻaina
• Nā Poʻomanaʻo Oralopa ʻo Januvia
• Berlithion (Berlithion) Nā papa ʻōlelo Oral
• ʻO nā papa ʻaina
• Nā papale Oralakaʻo Langerin (Lanagerin)

** ʻO ke kuhikuhi ʻana i ka hana lapaʻau no nā ʻike ʻike wale nō. No ka ʻike hou aku, e kiʻi i ka annotation a nā mea hana. Mai hoʻolaʻa ponoʻī, ma mua o ka hoʻomaka ʻana o ka hoʻohana ʻana i ka lāʻau ʻo Movogleken pono ʻoe e kamaʻilio i ke kauka. ʻAʻole kuleana ʻo EUROLAB no ka hopena i hoʻoiho ʻia e ka ʻike o ka ʻikepili i hōʻike ʻia ma ka waihona. ʻAʻole hoʻohuli nā ʻikepili ma ka pūnaewele i ka ʻōlelo aʻo a ke kauka a ʻaʻole hiki ke lawelawe me ka hōʻoia ʻana o ka hopena maikaʻi o ka lāʻau.

Ke makemake nei ʻoe i ka Movoglecen? Makemake ʻoe e ʻike i nā ʻikepili hou aʻe a makemake paha e ʻike i ke kauka? A i ʻole makemake paha ʻoe i ka hoʻokolokolo? Hiki iā ʻoe e hana me ke kauka - Lūkini Euro labepela mau i kāu lawelawe! E nānā nā kauka maikaʻi iā ʻoe, e aʻo aku, e hāʻawi i ke kōkua e pono ai a hana i kahi maʻi maʻi. Hiki iā ʻoe ke kāhea i ke kauka ma ka home. ^ E Ha yM. Klinika Euro labepela wehe iā ʻoe a puni ka uaki.

** Manalo! ʻO ka ʻike i hōʻike ʻia i loko o kēia alakaʻi lāʻau i manaʻo ʻia no nā mea lapaʻau a ʻaʻole pono ia i kumu no ka lāʻau lapaʻau ponoʻī. Hāʻawi ʻia ka wehewehe ʻana o ka lāʻau Movoglecen no ka ʻike a ʻaʻole i manaʻo ʻia no ke koho pono ʻana i ka mālama ʻana me ke komo ʻole o kahi kauka. Pono ka poʻe maʻi i nā ʻōlelo aʻo kikoʻi!

Inā makemake ʻoe i nā lāʻau āpau a me nā lāʻau lapaʻau, ko lākou wehewehe a me ka ʻōlelo pili no ka hoʻohana ʻana, ka ʻike e pili ana i ka haku ʻana a me nā puka o ka hoʻokuʻu ʻana, nā hōʻailona no ka hoʻohana a me nā hopena ʻaoʻao, nā hana o ka hoʻohana ʻana, nā kumukūʻai a me nā loiloi o nā lāʻau lapaʻau, a i ʻole ia he mea. mau nīnau a me nā manaʻo - e kākau iā mākou, e hoʻomaʻamaʻa mākou e kōkua iā ʻoe.

Ka hoʻohana ʻana o Movoglechen i ka wā hāpai a me ka hānai

ʻO ka māhele FDA o ka hana no ka pūpū ʻo C.

I ka hihia o ka hoʻohana ʻana i ka wā hāpai, hiki ke hoʻopau ʻia i ke kauoha ma mua o ka mahina mua ma mua o ka hānau ʻana i manaʻo ʻia a me ka neʻe ʻana i ka maʻi i ka insulin.

I ka manawa mālama e ho'ōki i ka umauma.

Hoʻolālā: hoʻihoʻi i ka lāʻau, hoʻōla glucose a me / a i ʻole ka hoʻololi ʻana i ka papaʻai me ka nānā ʻikepili ʻana i ka maʻi glycemia, me ka hypoglycemia koʻikoʻi (coma, epileptiform seizure) - hospitalization koke, hoʻomālamalama o kahi hāleʻa glucose intravenous 50% me ka infusion nā wā (iv drip) 10 ʻO ka hopena o ka glucose% hōʻoia e hōʻoia ai i kahi kahe koko glucose ma luna o 5.5 mmol / L, pono ka nānāʻana i ka glycemia no 1-2 mau lā ma hope o ka mea maʻi e haʻalele ai i ka coma. ʻAʻohe kūpono ʻo Dialysis.

ʻO ka mineral a me nā glucocorticoids, amphetamines, anticonvulsants (hydantoin derivatives), asparaginase, baclofen, calcium antagonists, carbonic anhydrase inhibitors (acetazolamide), chlortalidone, oral contraceptives, epinephrine, ethacinic acid, giurimide, thymoside, thymegium nā hoʻonāʻau, triamteren a me nā lāʻau āpau e hoʻoiho i ka hyperglycemia. Hoʻokomo i nā steroid anabolic me androgens e hana i ka hana hypoglycemic. Pākuʻi i ka anticoagulants, NSAIDs, chloramphenicol, clofibrate, guanethidine, MAO inhibitors, probenecid, sulfonamides, rifampicin hoʻonui i ka uha o ka hapa kīʻaha i loko o ke koko (ma muli o ke kaʻe ʻana mai ka protein plasma) a hoʻomaikaʻi i ka biotransformation. Ketonazole, miconazole, sulfinpyrazone poloka kahe ole i ka hana a hoʻonui i ka hypoglycemia. E kū'ē i ke kua mua o ka waiʻona, hiki i ka uluʻana o kahi maʻi disulfiram-like (ʻeha o ka ʻōpū, hōʻeha, ka luaʻi, ke poʻo ʻeha. Hoʻonui ka lāʻau antithyroid a me myelotoxic i ka uluʻana o ka agranulocytosis, ke kau hope, i ka hoʻohui - thrombocytopenia.

No ka mea lohi o ka ʻano hana glipizide:

Mai ka pūnaehana hoʻuanu a me nā ʻōpū sensory: dizziness, headache, insomnia, ʻehaʻeha, hopohopo, ke kaumaha, hoʻohaunaele, gait ganggu, paresthesia, hypersthesia, pale ma mua o nā maka, ʻeha ka maka, conjunctivitis, retinal hemorrhage.

Mai ka ʻaoʻao o ka ʻōnaehana cardiovascular a me ke koko (hematopoiesis, hemostasis): syncope, arrhythmia, hypertension arterial, sensation of heat flings.

Mai ka ʻaoʻao o ka metabolism: hypoglycemia.

Mai ka hanu hana ʻana: anorexia, nuala, luaʻi, a ka manaʻo kaumaha i ka ʻāpana epigastric, dyspepsia, constipation, he hoʻohui i ke koko i ka papa.

Mai ka ʻili: rash, urticaria, itching.

Mai ka papa hana hanu: rhinitis, pharyngitis, dyspnea.

Mai ka pūnaehana genitourinary: dysuria, i hoʻemi ʻia ka libido.

ʻO nā mea'ē aʻe: makewai, haʻalulu, edema peripheral, ʻeha ʻole kūloko i ka ʻōpū o ke kino, arthralgia, myalgia, nā umauma, nā holoi ʻana.

No ka wikiwiki o ka hana o ka glipizide:

Mai nā piʻina o ka nūnao a me nā ʻatikala: nā poʻo, nā maʻi o ka ʻawaʻawa.

Mai ka pūnaehana cardiovascular a me ke koko (hematopoiesis, hemostasis: leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic a anemia aplastic.

Mai ka ʻaoʻao o ka hana metabolism: diabetes insipidus, hyponatremia, maʻi porphyrin.

Mai ka hanā hana ʻana: ka mualea, ka luaʻi ʻana, ka ʻeha ma ka wahi o ka epigastric, constipation, hepatitis cholestatic (ka pakanu o ka ʻili a me ka sclera, discoloration o ka aʻa a me kaʻeleʻele o ka urine, ʻeha i loko o ka hypochondrium ʻokoʻa).

Mai ka ʻili: erythema, rashes maculopapular, urticaria, photosensitivity.

ʻO nā mea'ē aʻe: hoʻonui i nā ʻike o LDH, ka phosphatase alkaline, kūkaʻa bilirubin.

ʻO nā maʻi o ka hana ʻana o ka hāpē, nā ate a me nā ʻōpū (pono e mālama mau i nā pae o ka glucose koko), nā makahiki o nā keiki (ʻo ka maikaʻi a me ka palekana o ka hoʻohana ʻana i nā keiki ʻaʻole i hoʻokau).

Hypersensitivity, maʻi kakano ketoacidosis, Diabetic coma, juvenile type 1 diabetes mellitus, fever, trauma, lapaʻau, hapai, umauma.

ʻO ka maʻi diabetes mellitus type 2 i ka lilo ʻole o ka hopena o kahi meaʻai mālama haʻahaʻa, kūpono i ke kino pilikino, a pēlā aku, microangiopathy diabetes.

ʻO ka hopena lāʻau lapaʻau he hypoglycemic. Hoʻokumu i ka hoʻokuʻu ʻana o ka insulin mai nā hana beta pancreatic active functionally. E hōʻemi ana i ke kiʻekiʻe o ka hemoglobin glycosylated a me ka hoʻomehana ʻana i ka glucose o ka glucose i nā mea maʻi me nā maʻi maʻalahi a me nā maʻi koʻikoʻi o ka diabetes mellitus-non-insulin. Hoʻemi i ka hyperglycemia ma hope o ka meaʻai, hoʻonui i ka hoʻohaʻahaʻa glucose a me ka hoʻomaʻemaʻe ʻana i ke kahe manuahi (i kahi liʻiliʻi). Hoʻomoe ka pane insulinotropic i loko o 30 mau minuke ma hope o ka lawelawe ʻana i ka waha, ʻo ka lōʻihi o ka hana me ka pākahi hoʻokahi nō hiki i nā hola 24. ʻAʻole ia e pili i ke ʻano o ka lipid o ka plasma koko.

Ma nā hoʻokolohua ma luna o nā kaikahe a me nā kaole ma nā heʻe 75 mau manawa i ʻoi aku ai ma mua o MPD, ʻaʻole ia e hoʻonāukiuki i ka carcinogenesis a ʻaʻole i hoʻopilikia i ka mahiʻai (mauʻu). ʻAʻole i hōʻike ʻia nā haʻawina e pili ana i nā huakini a i ka vivo.

Hoʻohālikelike koke ʻia ka ʻano hana wikiwiki. ʻAʻole ʻai i ka ʻai i ka nui o ka hoʻopili ʻana, akā e hoʻolohi iā ia no 40 mau minuke. Hoʻoholo ʻia Cmax i nā hola 1-3 ma hope o hoʻokahi pae wai. ʻO T1 / 2 he mau manawa he 2: 19. Ma hope o ka lawe ʻana i ka hana lohi, ʻike ʻia ia i loko o ke koko ma hope o nā hola 2-3, hiki ke loaʻa ʻo Cmax ma hope o nā hola 6.12. Ua hoʻopaʻa ʻia i nā protein plasma koko i nā 98-199%. ʻO ka puʻu hoʻoili ma hope o ka hoʻomoe ʻana ʻo iv mea he 11 l, ʻo ka awelika ʻo T1 / 2 he 2-5 hola. ʻO Biotransformed i loko o ka palu (me ka hoʻomaka mua - ka liʻiliʻi). ʻOi aku ka emi o 10% i hoʻololi ʻia i ka urine a me nā kinikini, ma kahi o 90% e hoʻopiʻi ʻia ma ke ʻano o nā metabolites me ka urine (80%) a me nā feces (10%).

ʻO ka pauka keʻokeʻo ʻāpono lau ʻai. Kāhea i loko o ka wai a me ka waiʻona, akā hoʻoheheʻe ʻia i loko o kahi hoʻonā 0.1 mol / L NaOH a hoʻihoʻi nui ʻia i ka dimethylformamide.

N-2-4- (Cyclohexylamino) carbonylamino sulfonylphenylethyl-5-methylpyrazine carboxamide