Rosuvastatin a me Atorvastatin: ʻoi aʻe ka maikaʻi?

Hoʻohana ʻia ka Rosuvastatin a i Atorvastatin e mālama i nā maʻi e pili ana i ka hypercholesterolemia. ʻO nā lāʻau ʻelua i waena o nā lāʻau maikaʻi loa no ka hoʻohaʻahaʻa i ka kolamu koko (kolamu). Inā hoʻohana pololei, hoʻomaʻamaʻa ʻole lākou i ka hopena o ka hopena.

Nā hiʻohiʻona o Rosuvastatin

ʻO Rosuvastatin kahi lāʻau lapaʻau anticholesterolemic 4-hanauna maikaʻi. Aia kēlā me kēia papa i kahi mai 5 a 40 mg o ka waiwai ikaika o ka rosuvastatin. ʻO ka hui pūʻana o nā mea kōkua e hōʻike ʻia e ka: colloidal silicon dioxide, lactose monohidate, ke kō a me ka palaoa, nā mea kanu.

Hāʻawi nā statins i ka hoʻonui nui ʻana o ka hana i nā mea kūmole lipoprotein haʻahaʻa, e alakaʻi ana i ka hōʻemi o kā lākou helu. I ka manawa like, hoʻemi ka nui o ke kolamu o ke koko a hoʻonui i ka nui o nā lipoproteins density kiʻekiʻe. Hoʻomaka ka hopena therapeutic ma kahi o 7 mau lā ma hope o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa. Loaʻa ka hopena kiʻekiʻe ma hope o hoʻokahi mahina mai kahi o ka hoʻomaka ʻana o ka papa hana.

Hōʻike ʻia kēia lāʻau lapaʻau e kahi bioavailability haʻahaʻa haʻahaʻa - ma kahi o 20%. Aneane āpau i lawe i ka nui o kēia mau waiwai i nā protein plasma. Hoʻokuʻu ʻia ia me nā feces i loli ʻole. ʻO ka manawa e hōʻemi i ka pae o ka rosuvastatin i loko o ke koko ma ka hapalua he 19 hola. Hoʻonui ia me nā phaima a me nā hana o ke kua.

Hōʻike ʻia ka lāʻau lapaʻau no ka mālama ʻana i nā ʻano ʻano like ʻole o ka hypercholesterolemia i nā maʻi o nā makahiki 10 mai nā makahiki he nui. Hoʻomaopopo ʻia kēia ʻano hana me ka hoʻohui ʻana i ka meaʻai me ka haʻahaʻa haʻahaʻa haʻahaʻa, i ka wā e hōʻemi ʻia ai ka maikaʻi o ka pono therapeutic. Kuhi ʻia ka Rosuvastatin no ka genetically determin homozygous hypercholesterolemia.

Hōʻike ʻia ka Rosuvastatin i mea hoʻomaʻamaʻa maikaʻi no ka pale ʻana i kekahi mau maʻi cardiovascular ma ka poʻe i hiki mai.

Lawelawe ʻia ʻo Rosuvastatin ma ke ʻano. Ma mua o ka hoʻomaka ʻana i ka maʻi, e hele ana ka mea maʻi i kahi meaʻai me ka kolamu haʻahaʻa. Koho ʻia ka maʻi ma ke ʻano e hōʻike ana i nā hōʻike pilikino, nā ʻano o ke kūlana olakino o ka maʻi. Hoʻomaka ka make - mai 5 mg. Ke hoʻoponopono nei i ka nui o nā waiwai i lawe ʻia ma nā hebedoma 4 ma hope o ka hoʻomaka ʻana o ka mālama ʻana (me ka ʻike ʻole ka maikaʻi).

• i nā makahiki o ke ahonui a hiki i ka 18 makahiki,
• kanaka ma luna o 70 makahiki paha
• nā mea maʻi me nā pathology o kaʻeha, ate,
• nā mea maʻi e loaʻa ʻole ana i ka myopathies.

Lawe ʻia ka lāʻau me ka akahele inā he nui ka hana o ka mea maʻi i nā enzyme o ka moʻo.

Hoʻokomo ʻo Rosuvastatin i kēia mau hopena:

• ka hoʻomohala ʻana o ka hyperglycemia,
• āhāhuʻe
• ʻeha ka ʻōpū
• luhi, luhi
• lie kanikela
• constipation
• ʻeha i nā ʻeha a me nā ʻōpū,
• ka mahuahua o ka nui o ka protein i ka urine,
• nā hopena kūlohelohe
• ʻolua, ulu ka umauma.

ʻO ka hōʻeha nui o nā hopena maikaʻiʻole i ka wā o ka hōʻemi o ka cholesterol e hilinaʻi ana i ka hopena. Hoʻopiʻi ka lāʻau ma:

• ka holomua o kēlā me kēia ʻano hana a i ʻole nā ​​mea kōkua pilikino,
• nā maʻi heʻumi o nā ʻōpū a me nā ʻōpū (me ka mōʻaukala o)
• ʻaʻole maikaʻi loa ka thyroid
• ka ʻaloʻakā maʻi
• no ka lāhui Mongoloid (i kekahi o kēia lāʻau ʻaʻole hōʻike ka hana olakino)
• hoowalania ka io kino,
• hapai
• hana waiū.

Hoʻohanohano Atorvastatin

ʻO ka Atorvastatin kahi lāʻau lapaʻau maikaʻi anti antolololika Generala. Ka hoʻonohonoho pū ʻana o nā papa i ka atorvastatin a me ka mea hana mai 10 a 80 mg. Hoʻopili hou nā mea kanu lactose.

Ma Atorvastatin ma nā liʻiliʻi liʻiliʻi e hōʻemi pono i ka hana o nā enzyme e hāʻawi ana i ka hoʻopili ʻana i nā lipoproteins low density. I ka manawa like, ke hoʻonui nei ka nui o ka cholesterol kiʻekiʻe.

Hoʻohana ʻia ka hoʻohana ʻana o kēia pono hana i ka emi ʻana o ka make i ke kino mai ka maʻi naʻau coronary, ʻo ia hoʻi myocardial infarction.

ʻO ka lāʻau lapaʻau ka hōʻemi i nā pinepine o nā puʻuwai cardiovascular a me cerebrovascular.

Ma hope o ka hoʻokō kūloko ʻana, ua hoʻopaʻa ʻia i loko o ka ʻeha gastrointestinal no kekahi mau hola. ʻO ka loaʻa ʻana o nā mea ikaika ma ka hihia o ka hoʻokūkū waha. Aneane piha ke kiko o ka lāʻau i hoʻohana ʻia me nā protein plasma. E hoʻololi i loko o nā ʻili o ka pepī me ke kāpili o nā metabolites hoʻāla lāʻau pharmacologically.

Hoʻopau ʻia ka lāʻau lapaʻau i loko o ke ake. ʻO ka hapalua o ke ola o ka lāʻau lapaʻau ma kahi o 14 mau hola. ʻAʻole ia i hōʻino ʻia e ka dialysis. Me ka hana o ka pehu a pau, he liʻiliʻi iki i ka piʻi ʻana o ka waiwai ma o ke koko.

Nā hōʻailona no ka koho ʻana:

• ka hana paʻakikī ʻana i ka kolamu kiʻekiʻe ma ke koko,
• ka heleʻana o nā mea e pili ana i ka hoʻomohala ʻana o ka maʻi naʻau coronary, ka maʻi maʻi maʻa,
• ka ʻike ʻana o ka mōʻaukala o nā ala no ka puʻuwai a me nā kīʻaha koko.
• maʻi maʻi
• ka hele ʻana o nā keiki o ka hoʻomakeholo o nā kāpala e ka pilina me ka heitiszygous herceary hypercholesterolemia.

Ma mua o ka lawe ʻana i kēia lāʻau lapaʻau, hoʻoneʻe ʻia ka mea maʻi i ka meaʻai kūpono me ka cholesterol haʻahaʻa. ʻO ka hapa haʻahaʻa o kēlā me kēia lā he 10 mg, ka mea i lawe ʻia i ka manawa 1 i kēlā me kēia lā, me ke ʻano o ka manawa ʻaina. ʻO ka lōʻihi o ka mālamaʻana, hiki ke hoʻonui ʻia ma ke ʻano he lāʻau kauka, e nānā ana i ka dinamika o ke ʻano o ka mea maʻi.

ʻO ka dosis kiʻekiʻe loa no nā pākeke he 80 mg o atorvastatin. Ua ʻōlelo ʻia nā keiki mai 10 mau makahiki i ka 20 mg o kēia lāʻau lapaʻau. Hoʻohana ʻia ka like o ka haʻahaʻa like i ka mālama ʻana i nā poʻe maʻi me nā maʻi palaleka a me nā maʻi. ʻAʻole koi nā poʻe ma luna o 60 i kahi loli loli.

ʻO nā hopena ʻaoʻao a me nā contraindications e like me ka Rosuvastatin. I kekahi manawa luhi ka hana a nā kāne. I nā keiki, hiki i nā hopena like ʻole:

• pākuʻi, helu haʻahaʻa,
• loaʻa ka paona
• alo wale a pilau kekahi manawa
• ka mumū o ka ʻāʻī
• ka ʻaʻa o ka bile
• hemo o nā tendons a me nā liʻi,
• hoʻomohala ʻana i ka edema.

Ke hoʻohālikelike huakaʻi

Hoʻohālikelike ka hoʻohālikelike o kēia mau mea hana e koho i ke ala maikaʻi loa e mālama ai i ke kolamu kiʻekiʻe.

Pili kēia mau lāʻau i nā statins. He kumu synthetic lākou. ʻO Rosuvastatin a me Atorvastatin he hana like like o nā hana, nā hopena ʻaoʻao a me nā contraindications, nā hōʻailona.

Hoʻopili maikaʻi nā lāʻau ʻelua i ka HMG-CoA reductase, nāna ke kuleana kolamu. Hoʻopilikia kēia hana hoʻi i ke ʻano maʻamau o ka mea maʻi.

He aha nā meaʻokoʻa?

ʻO ka ʻokoʻa ma waena o kēia mau ʻano ka mea ʻo Atorvastatin no nā statins o 3 mau hanauna, a ʻo Rosuvastatin - ka hope loa, 4 mau hanauna.

ʻO ka ʻokoʻa ma waena o lākou ʻo ka rosuvastatin e koi i kahi haʻahaʻa haʻahaʻa e hoʻolako i ka hopena therapeutic e pono ai.

Ma muli, hoʻohālikelike ʻia nā hopena ʻaoʻao mai ka lāʻau statin.

Hiki paha ke hoʻololi mai Atorvastatin i Rosuvastatin?

Hoʻololi loa i ka loli ʻana i nā lāʻau lapaʻau me ke ʻole o ka ʻae mua a ke kauka. ʻOiai ke kūleʻa nei nā lāʻau ʻelua i nā statins, ʻokoʻa kā lākou hopena.

Ua hoʻoholo ke kauka i ka loli o nā lāʻau lapaʻau pinepine me ka hoʻomau ʻole ʻana o kēlā me kēia ʻāpana. ʻAʻole loli ka mea kūpono o ka mālamaʻana.

ʻO wai ka mea maikaʻi - rosuvastatin a atorvastatin?

Ua hōʻike ʻia nā haʻawina hauoli ʻana i ka hapalua o ka nui o ka rosuvastatin i ʻoi aku ka maikaʻi ma mua o ka nui o ka atorvastatin. ʻO nā pae kolamu o ke koko i ka wā e lawe ai i nā statins o nā hanauna hou i hoʻemi nui ʻia.

ʻO Rosuvastatin (a me kāna kikowaena) ʻoi aku ka maikaʻi o ka kolamu kiʻekiʻe kiʻekiʻe, no laila, loaʻa nā pono i ka wā i kuhikuhi ʻia. Hoʻomaopopo kēia i ka manaʻo o nā mea kūʻai aku.

Hoʻomaka ʻo Rosuvastatin e wikiwiki i ka hana. ʻOi aku ka maikaʻi ʻia e nā mea maʻi a hōʻemi i nā hopena liʻiliʻi.

ʻO ka manaʻo o nā kauka

Aleksey, 58 mau makahiki, ʻoihana lapaʻau, ʻo Moscow: “I ka wā e lele ai ka cholesterol i ke koko i mea e pale ai i ka hoʻomohala ʻana o ka cerebral arteriosclerosis, ke kuhikuhi nei wau i nā mea maʻi e lawe iā Rosuvastatin. Hoʻopau maikaʻi ka lāʻau lapaʻau a ma ka manawa like me ke kumu no ka liʻiliʻi loa o nā hopena maikaʻiʻole. Manaʻo wau e hoʻomaka i ka mālama ʻana me kahi maʻi o 5-10 mg. Ma hope o hoʻokahi mahina, i ka hihia o ka like ʻole o nā ʻano wai, ke noi aku nei au e hoʻonui. "E hoʻomanawanui ka poʻe maʻi i ka mālama ʻana a me ka ʻai haʻahaʻa haʻahaʻa, ʻaʻohe hopena hopena."

ʻO Irina, he 50 mau makahiki, ʻoihana ʻo Saratov: "I mea e pale ai i ka hoʻomohala ʻana o ka infoction myocardial, atherosclerosis a me ka hōʻeha i nā mea maʻi me nā maʻi metabolism, ʻoi aku wau i Atorvastatin iā lākou. Ke paipai aku nei wau iā ʻoe e lawe i ka liʻiliʻi liʻiliʻi ma mua (koho wau iā ia e like me nā hopena o nā hoʻokolohua lapaʻau). Inā ʻaʻole emi ka pae kolamu ma hope o hoʻokahi mahina, e hoʻonui i ka nui. Hoʻomaʻomaʻo ka poʻe maʻi i ka mālama ʻana i ka mālama ʻana, ʻaʻole lawa ka hopena ʻino. "

Nā Hōʻike Mane no Rosuvastine a me Atorvastine

Irina, 50 makahiki, ʻo Tambov: “Ua hoʻomaka pinepine ke kīhaha e piʻi pinepine. Ke huli nei i ke kauka, ua hoʻomaʻamaʻa ʻo ia i nā hoʻomaʻamaʻa pono a pau, i hōʻike ai he piʻi nui o ka kolamu koko. E hōʻemi i ka hōʻailona, ​​kuhikuhi ke kauka e inu iā Rosuvastatin 10 mg, 1 manawa i kēlā lā. ʻIke wau i nā hopena mua ma hope o 2 mau pule. Hoʻomau wau e lawe i kēia lāʻau lapaʻau no 3 mau mahina, ua hoʻonui nui ʻia koʻu olakino. ”

Olga, 45 mau makahiki, ʻo Moscow: "ʻO nā hōʻike hoʻolika hou o ka biochemical i loaʻa ua loaʻa iaʻu he kolamu kiʻekiʻe ma ke koko. No ka pale ʻana i ka hoʻomohala ʻana o ka atherosclerosis a me ka maʻi puʻuwai coronary, kuhikuhi ke kauka i 20 mg atorvastatin. Ke lawe nei au i kēia lāʻau lapaʻau i ke kakahiaka ma hope o ka ʻai ʻana. 2 mau pule ma hope o ka hoʻomaka ʻana o ka hoʻōla, ʻike ʻo ia i ka emi ʻana o kaʻu edema, hele aku ka luhi ma hope o ka hana kino kino. Ma hope o 2 mau lā o ka mālama ʻana, ua emi ke koko. Keʻimi nei wau i kahi meaʻai, hōʻole wau i nā huahana me ka cholesterol "maikaʻi". "

Poke? I? O man?

Koi ʻokoʻa Atorvastatin a me rosuvastatin:

• ʻano a me ka helu ʻana o nā mea ikaika (ʻo ka lāʻau mua loa e loaʻa ana i ka calcium atorvastatin, ʻo ka lua ka mea maʻa rosuvastatin),
• ka wikiwiki o ke komo ʻana o nā mea hana (Rosuvastatin e wikiwiki wikiwiki ana,)
• hapai hapalua-ola (ke kala wikiwiki ʻia ka lāʻau mua, no laila e pono ia e lawe i 2 mau manawa i ka lā).
• ka hana o ka metabolism o ka mea hana (atorvastatin i hoʻohuli ʻia i ka ate a hoʻopili ʻia me ka bile, ʻaʻole i hoʻopili ʻia ka rosuvastatin i nā kaʻina metabola a waiho i ke kino me nā feces).

ʻO wai ka mea palekana?

Hiki iā Rosuvastatin kahi lihi e hoʻopili i ka hana o nā aʻa a me nā pōpoki, no laila, manaʻo ʻia ʻoi aku ka palekana. Eia kekahi, loaʻa iā ia ka laula ākea o nā hopena ʻaoʻao e hoʻohālikelike ʻia i ka Atorvastatin.

Aia ʻo Atorvastatin i kahi ākea ākea o nā hopena ʻaoʻao ma mua o ka rosuvastine.

Nā Hōʻike Mane no Rosuvastatin a me Atorvastatin

Elena, 58 makahiki, Kaluga: "Ua hōʻike ʻia kahi hoʻokolohua he hoʻonui i ka cholesterol. Ua ʻōlelo aku ke kauka i ka atorvastatin a i ʻole rosuvastine e koho. Hoʻoholo wau e hoʻomaka me ka lāʻau lapaʻau mua, kahi haʻahaʻa haʻahaʻa. Lawe wau i nā kīmaha no hoʻokahi mahina, ua hui pū ʻia ka mālama ʻia e ke ʻano o nā rashes ʻeha a me kaʻeha. Uli wau i Rosuvastatin, a nalowale kēia pilikia. Ua hoʻi hou ka nui o nā kolamu ma ke koko a ʻaʻole hoʻonui no nā mahina ʻeono. "

Hoʻopili ʻana i nā Atorvastatin a me Rosuvastatin

ʻO ka Atorvastatin kahi lāʻau lapaʻau i loaʻa ka hopena hypocholesterolemic. I ka wā o ka pauku ma o ke kino, mālama ka mea pale aku i ka hana o nā molekone o ka enzyme e hoʻoponopono i ka hana o ka waʻa mevalonic. ʻO Mevalonate kahi mea i mua o ka sterols e loaʻa i nā lipoproteins haʻahaʻa haʻahaʻa.

Hoʻohana ʻia nā papa lālini statin e 3 i ka mālama ʻana i ka cholesterol kiʻekiʻe. I ka manawa o nā hōʻike atherosclerotic, ke hoʻohana nei ka lāʻau lapaʻau i ka hopena maikaʻi i ka hana lipid metabolism, hōʻemi i ka hoʻoliʻiliʻi o nā lipid lipid o LDL, VLDL a me nā triglycerides, ʻo ia ke kumu no ka hoʻokumu ʻana o ka neoplasms atherosclerotic. Ke hoʻohana nei i ka lāʻau lapaʻau, hōʻemi ka hōʻemi i ka pōmole koloka, me ka manaʻo o kona etiology.

Hoʻomaopopo ʻia ka lāʻau Rosuvastatin ma ka nui o ke kahe ʻana o nā molekene LDL i ka plasma koko. Aia ka lāʻau i ka pūʻulu o nā statins o ka hanauna ʻehā (hope), kahi o nā mea hana koʻikoʻi ʻo rosuvastatin. ʻO nā lāʻau lapaʻau o nā hanauna hou me ka rosuvastatin ka palekana no ke kino, a loaʻa iā lākou kahi hopena therapeutic kiʻekiʻe loa i ka mālamaʻana o hypercholesterolemia.

ʻO ke kānāwai o ka hana o ka lāʻau lapaʻau

ʻO ka Atorvastatin ka lāʻau lipophilic e hoʻōla i ka momona wale nō, a ʻo Rosuvastatin kahi lāʻau lapaʻau hydrophilic i hoʻohālikelike nui i ka plasma a me ka serum koko.

Maikaʻi ka hana o nā lāʻau lapaʻau hou i nā maʻi he nui i ke ʻano lāʻau lapaʻau hoʻokahi e hoʻohaʻahaʻa i ka kolamu, ʻo ka hapa o LDL a me VLDL, a me ka triglycerides.

Ka hana o ka hana o nā statins

ʻO nā ʻaina ʻelua he inhibitors o HMG-CoA reductase molekula. No ka hōʻemi i ke ʻano o ka hoʻoneʻe ʻana o ka mevalonic acid, ʻo ia kahi o nā sterol a he ʻāpana o ka molekala kolamu. ʻO nā molekule o ka cholesterol a me ka triglycerides kekahi mau haʻahaʻa o ka lipoproteins molina haʻahaʻa loa, kahi i hui pū ai i ka wā o ke kūleʻa o nā pupu ʻona.

Me ke kōkua o ka lāʻau lapaʻau, hoʻemi ʻia ka nui o ka cholesterol i hoʻokahe ʻia, ka mea e kaomi ana i nā mea hoʻokae LDL, ka mea i ka wā e hoʻōla ʻia, hoʻomaka ka hoʻohele no nā lipid haʻahaʻa haʻahaʻa, hopu iā lākou a lawe aku iā lākou no ka hoʻolei.

Mahalo i kēia hana o nā receptors, kahi emi nui i ka haʻahaʻa haʻahaʻa haʻahaʻa a me ka hoʻonui ʻana o nā lipids kiʻekiʻe i ke koko e kū nei, e pale ana i ka hoʻomohala ʻana o nā ʻōnaehana ʻōnaehana.

No ka hoʻohālikelike, e hoʻomaka i ka hana, ʻaʻole pono ʻo Rosuvastatin i nā loli i loko o nā peka o ka ate, a hoʻomaka ʻo ia e hana wikiwiki, akā ʻaʻole pili kēia lāʻau i ka hōʻemi o nā triglycerides. ʻAʻole e like me ka lāʻau hope loa, ua hoʻohuli ʻia ʻo Atorvastatin i loko o ke pepeke, akā maikaʻi nō ia i ka hoʻohaʻahaʻa ʻana i ka kuhikuhi ʻana o TG a me nā molekiola koloka ʻole, ma muli o kona lipophilicity.

Nā hōʻailona a me nā contraindications

ʻO nā lāʻau ʻelua ke kuhikuhi like i ka mālama ʻana o nā kuʻuna koloka kiʻekiʻe, a, eia naʻe ka ʻokoʻa o nā ʻōnaehana kemal, ʻo nā mea ʻelua o ka HMG-CoA reductase inhibitors. Pono e lawe ʻia nā papa statin me nā maʻi like ʻole i ka pale lipid:

• hypercholesterolemia o nā ʻano etiologies (familial a hui ʻia)
• paulakowalik
• kūlia
• systemher aticosclerosis.

Pēlā nō, ʻo nā lāʻau lapaʻau e kuhikuhi ʻia i nā mea maʻi ma ka hopena kiʻekiʻe o ka hoʻomohala ʻana i nā maʻi me vascular.

• haʻi maʻi
• ʻinalelo angina pectoris
• ischemia puuwai
• ischemic and hemorrhagic stroke,
• myocardial infarction.

ʻO ke kumu o ka hypercholesterolemia he mea kolohe i ka metabolid lipid, ka mea e ulu pinepine ana ma muli o ka hewa o ka mea maʻi ʻo ia iho no ka hewa o ke ola.

E kōkua ka loaʻa ʻana o nā statins i ka pale ʻana i ka hoʻomohala ʻana o ka pathology, inā lawe mau ʻoe iā lākou no nā kumu pale i ke alo o nā ʻano:

• nā meaʻai kiʻekiʻe i nā huahana momona momona,
• na mea inu waiʻaka a me ke kaulike nikotine,
• huhū a me nā hopohopo pinepine.
• ʻaʻole ia kahi hana hoʻoikaika kino.

ʻE ʻokoʻa nā contraindications no kēia mau lāʻau ʻelua (Papa 2).

Nā ʻōkuhi no ka hoʻohana

Pono e hoʻopili pono ʻia nā Statins me kahi nui o ka wai. Hoʻopili ʻia ka chewing i ka papa, no ka mea ke uhi ʻia me ka membrane e hoʻohemo ai i loko o nā ʻōpū. Ma mua o ka hoʻomaka ʻana i ka papa lāʻau me nā statins o ka hanauna 3 a me ka 4, pono e hoʻomanawanui ka mea maʻi i ka papa anticholesterol, a pono ke hele pū ka meaʻai i ka papa holoʻokoʻa o ka mālama ʻana me nā lāʻau lapaʻau.

Koho ke kauka i kēlā me ka wai a me ka lāʻau lapaʻau no kēlā me kēia maʻi, e pili ana i nā hopena o nā hoʻokolohua hōʻike, a me ka hoʻomanawanui ʻana o ke kino a me ke ʻano o nā maʻi maʻi. ʻO ka hoʻoponopono o ka dosis, me ka hoʻohuli ʻana i ka lāʻau lapaʻau me kekahi lāʻau lapaʻau ʻē aʻe, ʻaʻohe mea i hala ma mua o ʻelua pule mai ka manawa o ka hoʻokele.

Hoʻolālā Kūʻai ʻo Atorvastatin

ʻO ka maʻa mua no ka atherosclerosis systemic o Rosuvastatin he 5 mg, Atorvastatin 10 mg. Pono ʻoe e lawe i ka lāʻau lapaʻau i ka manawa 1 i ka lā.

ʻO ka papaʻi i kēlā me kēia lā i ka loaʻa ʻana o ka hypercholesterolemia o nā ʻano etiologies:

• me ka homozygous hypercholesterolemia, ʻo ke kumu o Rosuvastatin he 20 mg, Atorvastatin he 40-80 mg,
• i nā mea maʻi me ka heterzygous hypercholesterolemia - 10-20 mg o Atorvastatin, i māhele ʻia i ke kakahiaka a me ke ahiahi.

ʻO nā mea nui a me ka hoʻoholo pono

He aha ka mana ma waena o rosuvastatin a me atorvastatin? ʻO ka ʻokoʻa ma waena o nā lāʻau lapaʻau ka mea ʻike nui i ke kahua o ko lākou kiʻi ʻana mai ka ʻōpū liʻiliʻi. ʻAʻole pono ʻo Rosuvastatin e hoʻopili i ka manawa o ka ʻai ʻana, a hoʻomaka ka Atorvastatin e haʻalele i kāna mau waiwai inā e lawe ʻoe i kahi paila i ka wā pāʻina a i ʻole ma hope o ia.

Hoʻohana pū ka hoʻohana ʻana i nā lāʻau ʻē aʻe no kēia lāʻau lapaʻau, no ka mea ʻo kona hoʻololi ʻana i ke ʻano hana hana pū me ia me ke kōkua o nā enzymes cell ate. Hoʻokuʻu ʻia ka lāʻau mai ke kino me ka huehue bile.

Hoʻopili ʻia ʻo Rosuvastatin i nā loli. Mai poina e pono no kahi mālama lōʻihi, pono nā waiwai kālā. ʻO Atorvastatin ka 3 mau manawa i ʻoi aku ai ma mua o statin 4 mau hanauna, no laila e loaʻa ana i nā ʻāpana ʻokoʻa o ka heluna kanaka. ʻO ke kumukūʻai o atorvastatin (10 mg) - 125 rubles., 20 mg - 150 rubles. ʻO ke kumu kūʻai o Rosuvastatin (10 mg) - 360 rubles., 20 mg - 485 mau rubles.

E hana like kēlā me kēia lāʻau ma ke kino o kēlā me kēia maʻi. Koho ke kauka i nā lāʻau lapaʻau e like me ka wā, ka patula, ka pae o ka holomua a me nā hōʻailona o ka ʻaoʻao lipid. ʻO Atorvastatin a i ʻole Rosuvastatin e hōʻemi i ka cholesterol kino a me ke ala like - i loko o 50-54%.

Ua kiʻekiʻe iki ka hopena o Rosuvastatin (i loko o 10%), no laila, hiki ke hoʻohana ʻia kēia mau waiwai inā he haʻahaʻa ka haʻahaʻa o ka cholesterol ma mua o 9-10 mmol / L. Eia kekahi, ʻo kēia lāʻau lapaʻau i ka manawa pōkole loa hiki ke hoʻemi i ka OXC, e hōʻemi ana i ka nui o nā hopena o ka ʻaoʻao.

Nā hopena maikaʻiʻole

ʻO ka hopena maikaʻi o ka lāʻau lapaʻau ma ke kino ke kumu nui o ke koho ʻana i ka lāʻau. Aia nā ʻākana i kēlā mau lāʻau lapaʻau, inā i lawe ʻole ʻia, hiki ke make. I mea e pale ai i nā hopena hopena, ʻaʻole e nui ʻia ka nui o ka lāʻau i hōʻike ʻia e ke kauka a pono loa e hahai ʻia kāna mau ʻōlelo aʻo.

ʻO ka mea maʻi mai 100 aku i kēia nā hopena maikaʻi ʻole:

• ka ʻūhā, ʻo i ka hoʻomanaʻo ʻana
• kūlana kaumaha
• nā pilikia pili kino.

I ka mea maʻi ma waho o ka 1000, hiki i nā hopena like ʻole o ka lāʻau lapaʻau.

• anemia
• hōʻeha a me ka pīhoihoi me ke ʻano like ʻole,
• aloha
• wahī ʻaʻe
• polyneuropathy
• anorexia
• lōkohu
• ʻāwīwī ʻana i ka maʻi ʻeha e hōʻeha i ka ʻōpū a me ka hoʻopuka,
• hoʻonui a hōʻemi paha i ke kahe koko,
• nā ʻano like o ka hepatitis,
• allergic rashes a weliweli koʻikoʻi,
• urticaria
• alopecia
• myopathy ame myositis,
• ʻaiaiaia
• angioedema,
• ʻōhumu ʻōnaehana
• wahīwiki
• polymyalgia o kahi ʻano rheumatic,
• thrombocytopenia
• eosinophilia
• hematuria a me proteinuria,
• kaumaha ʻeha o ka ʻōpū
• ulu male male a luhi.

I nā hihia koʻikoʻi, hiki i ka rhabdomyolysis, nā māpili a me nā puʻuwai e ulu.

Hoʻopili pū kekahi me nā lāʻau lapaʻau a me nā hōʻailona

ʻAʻole hiki ke hoʻohui pū ʻia nā Statins me nā lāʻau āpau. I kekahi manawa ke hoʻohui pū i nā lāʻau lapaʻau ʻelua hiki i ka hopena ʻaoʻao.

1. Ke hui pū me ka cyclosporine, loaʻa mai ka hopena o ka myopathy. Hoʻopilikia ʻia kaʻu Myopathy i ka hui pū ʻana me nā hui antibacterial tetracycline, clarithromycin a me nā hui erythromycin.
2. Hiki ke loaʻa ka hopena ʻino o ke kino i ka wā e lawe ai i nā statins a me nā niacin.
3. Inā oe e lawe iā Digoxin a me statins, he nui i ka manaʻo o Digoxin a me nā statins. ʻAʻole ia e hāʻawi ʻia e lawe i nā papa statin a me ka waiʻāpala. Hoʻemi ka waiʻona i ka hopena o ka lāʻau o statin, akā e hoʻonui i kona hopena maikaʻi ʻole i nā kino a me nā ʻōnaehana i ke kino.
4. Ka hoʻokaʻawale ʻana o ka hoʻohana ʻana o nā papa statin a me nā antacids, a me ka magnesium, e hōʻemi i ka neʻe o ka statin i nā manawa 2. Inā ʻoe e hoʻohana i kēia mau lāʻau lapaʻau me ke kaʻina o nā hola 2-3, a laila ua hoʻemi ʻia ka hopena maikaʻi ʻole.
5. Ke hoʻohui i ka hoʻokomo o nā papa a me nā inhibitor o ka protease (HIV), a laila nui ka nui o ka AUC0-24. No nā poʻe i maʻi ʻia, contraindicated a he hopena koʻikoʻi.

Loaʻa iā Atorvastatin 4 mau laikini, a ʻo Rozuvastatin - 12. Lūkini Lūkini o Atorvastatin-Teva, Atorvastatin SZ, ʻAkona Atorvastatin he haʻahaʻa haʻahaʻa me ka maikaʻi maikaʻi. ʻO ke kumukūʻai o nā lāʻau lapaʻau mai 110 ka 130 mau rubles.

ʻO nā mea pono e pili ana i ka rosuvastatin:

1. ʻO Rosucard kahi lāʻau lapaʻau Lūkini e hoʻohaʻahaʻa pono i ka cholesterol no kahi papa lāʻau therapeutic pōkole.
2. ʻO Krestor kahi lāʻau lapaʻau ʻAmelika kahi ala kumu mua o nā statins o 4 mau hanauna. Krestor - i hele i nā haʻawina kula a me ka ʻoihana keʻena. ʻO ke kumu hoʻohālikelike o loko nei ʻo ia ke kumu o 850-1010 mau rubles.
3. ʻO Rosulip kahi lāʻau lapaʻau Hungarian i hōʻike pinepine ʻia no ka atherosclerosis no ka hoʻohana lōʻihi.
4. ʻO ka lāʻau lapaʻau Hungarian ʻo Mertenil - i kuhikuhi ʻia no ka hoʻohaʻahaʻa i ka cholesterol maikaʻi ʻole a no ka pale ʻana i nā maʻi maʻi.

Hoʻohui pinepine ʻia nā loiloi e pili ana i nā statins, no ka mea ke kākoʻo nei nā poʻe cardiologists i ka lawe ʻana i nā papa statin, a me nā mea maʻi, e makaʻu ana i ka hopena maikaʻi ʻole o ke kino, e kūʻē i ko lākou hoʻohana ʻana. E kōkua nā loiloi mai nā kauka a me nā mea maʻi e hoʻoholo i ka mea ʻoi aku ka maikaʻi atorvastatin a i rosuvastatin:

ʻO nā statins 3 a me nā hanauna 4 he maikaʻi loa i ka mālama ʻana i nā maʻi ʻōnaehana a me ka maʻi cardiological. Hiki i ke koho kūpono i nā lāʻau lapaʻau ke hana wale ʻia e ke kauka a hiki i nā lāʻau lapaʻau ke lawe mai i nā pono kiʻekiʻe loa me nā hopena maikaʻi ʻole.

He aha nā helu?

ʻO statins kahi papa i hoʻokaʻawale ʻia o lipid-hoʻohaʻahaʻa (lipid-hoʻohaʻahaʻa) i nā lāʻau lapaʻau i hoʻohana ʻia e mālama i ka hypercholesterolemia, i.e., i ka pae kiʻekiʻe o ka kolamu (XC, Chol) i ke koko, ʻaʻole hiki ke hoʻēmi ʻia me ka hoʻohana ʻana i nā lāʻau lapaʻau ʻole-lāʻau lapaʻau: ke ola olakino, ʻakena a me nā meaʻai.

Hoʻohui i ka hopena koʻikoʻi, aia nā statins i nā waiwai ʻē aʻe e pale ai i ka hoʻomohala ʻana o nā koi cardiovascular koʻikoʻi:

• ka mālama ʻana i ka ulu o nā plak atherosclerotic ma ke kūlana paʻa,
• hoʻoliolo ʻia ke koko e ka hoʻēmi ʻana ʻana i ka platelet a me ka erythrocyte aggregation,
• kaohi ʻana o ka mumū o ka endothelium a hoʻihoʻi i kāna hana,
• ka hooulu ana o ka synthesis o nitric oxide, pono no ka hoʻomaha o nā moku koko.

ʻO ka maʻamau, ua lawe ʻia nā statins me ka nui o ka maʻamau o ka cholesterol i ʻae ʻia - mai 6.5 mmol / l, akā naʻe, inā e hōʻeha ka mea maʻi i nā mea (genetic form of dyslipidemia, nā atherosclerosis, hōʻeha o ka puʻuwai a me ka hanana hōʻeha), a laila ua kuhikuhi ʻia lākou ma nā haʻahaʻa haʻahaʻa - mai 5 8 mmol / L.

Ka ʻōlelo hoʻonohonoho a me ke kumu o ka hana

Ka hui pū ʻana o nā lāʻau lapaʻau Atorvastatin (Atorvastatin) a me Rosuvastatin (Rosuvastatin) e hoʻohui i nā mea synthetic mai nā hanauna hou o nā statins ma ke ʻano o ka paʻakai kalepa - atorvastatin calcium (III hanauna) a me ka kalepona rosuvastatin (IV hanauna) + mau mea kōkua, me ka waiʻu derivatives (lactose monohydrate) )

Hoʻokumu ka hana o nā statins i ka pale ʻana i ka hoʻoneʻe o ka huina, nona ke kuleana no ka hoʻokumu ʻana o ka kolamu ma ka ate (he kumu no kahi 80% o ka waiwai).

Hōʻalo ka hana o nā lāʻau ʻelua ke ʻano i ka nui o ka enzyme nui e kuleana ai no ka hana kolamu: ma ka hoʻokaʻawale ʻana (a hoʻohiolo) i ka synthesis o HMG-KoA reductase (HMG-CoA reductase) i ka puʻuwai, hōʻemi lākou i ka hana o ka waika mevalonic, kahi mua o ka koluna (endogenous) kolesterol.

Eia kekahi, hoʻonāukiuki nā statins i ka hoʻokumu ʻana i nā receptors e alakaʻi i ka lawe ʻana i nā lipoproteins haʻalulu haʻahaʻa (LDL, LDL), ʻo ka haʻahaʻa haʻahaʻa haʻahaʻa (VLDL, VLDL) a me ka triglycerides (TG, TG) i ka hoki i ka puhipuhi no ka hoʻohemo, e alakaʻi ana i kahi hōʻemi o ke kolamu "kolamu" maikaʻi. i loko o kahi serum.

ʻO ka mea kūʻokoʻa o nā statins hou, ʻaʻole lākou i pili i ka metabolism i ke kīhaka, i.e., Atorvastatin a me Rosuvastatin he mea hoʻonui wale i ka kukuna glucose, e ʻae nei i nā poʻe me ka ʻano like ole-insulin i ke ʻano o ka maʻi II e lawe ai iā lākou.

Atorvastatin a i ʻole Rosuvastatin: ʻoi aku ka maikaʻi?

ʻO kēlā me kēia synthesis o hope o ka lāʻau hoʻoneʻe e hāpai i ka hiʻohiʻona o nā ʻano lāʻau lapaʻau ʻē aʻe i loko, kēlā, kēlā me kēia ʻo Rosuvastatin i ʻokoʻa i ka Atorvastatin i nā hiʻohiʻona hou e hana nei i nā lāʻau lapaʻau e pili ana i ka ʻoi aku ka maikaʻi a me ka palekana.

Hoʻohālikelike o Atorvastatin a me Rosuvastastinn (papa ʻaina):

ʻO ka hoʻohana ʻana o Atorvastatin a me Rosuvastatin ma nā pihi pāʻālua a kokoke me ka hoʻokaʻawale ʻana i ke kiʻekiʻe o ka cholesterol "hewa" - ma ka 48-54% a me 52-63%, no laila ke koho maikaʻi ʻana i ka lāʻau i kēlā me kēia hihia i ka kū hoʻokahi kanaka like o ke kino o ka mea maʻi.

• ke kāne, ka ʻāina, ka heredity a me ka hypersensitivity i ka mana,
• maʻi hana a me ka maʻi pā ʻana
• Nā lāʻau lapaʻau i lawe ʻia ma ke ʻano, ʻokoʻa a me ka noho ʻana.
• nā hopena o nā noi ʻana o ka hana noiʻi a me nā hana pono.

ʻOi aku ka maikaʻi o Rosuvastatin no ka mālamaʻana i ka hypercholesterolemia i nā poʻe me ka pilikia o ka ate a me ka pancreas. ʻAʻole e like i nā statins i hala, ʻaʻole pono ia i ka hoʻololi ʻana, akā komo koke i ke kahe koko. Hoʻokumu ʻia ʻo ia hoʻi ma o nā ʻāpana o ka huina, kahi e hoʻemi ana i ka hana ma luna o kēia mau kino.

Inā loaʻa kahi maʻi kiʻekiʻe i kahi kanaka kiʻekiʻe, a laila pono ke koho ʻia atorvastatin. Ma muli o kāna momona momona, ua hana ikaika ia i ka wāwahi ʻana i nā lipids maʻalahi a pale i ka hoʻololi ʻana o ka cholesterol mai ka momona o ke kino i loaʻa.

I mua o ka hepatosis momona a i ʻole cirrhosis o ka puʻuwai, e lawe pinepine ana i Atorvastatin i ka nānā ʻana i ka paʻa ʻana o nā ʻaina hepatic i loko o ke koko, no laila, i ka haʻalele ʻana o ka momona, no ka hoʻomohala ʻana i ka wā lōʻihi e noi ʻia e koho i ka statin me ka haʻahaʻa o ka waiwai a me ka hopena o ka "hopena ʻaoʻao", ʻo ia hoʻi, ʻo Rosuvastatin.

Nā ʻ Efflelo ʻaoʻao Hoʻohālikelike Chart

Inā hilinaʻi ʻoe i ka hana lapaʻau a me nā loiloi o nā poʻe maʻi e lawe nei i nā statins no ka manawa lōʻihi, i ka wā e hoʻohana ai i nā helu kiʻekiʻe o ka waiwai ikaika o ka hanauna a III a me IV, i nā hihia hanana (a hiki i 3%), nā hopena hopena o nā ʻano paʻakikī i kekahi mau pūnaehana o ka kino e ʻike ʻia.

ʻO ka hoʻohālikelike o nā "ʻaoʻao ʻaoʻao" o Atorvastatin a me Rosuvastatin (papa):

Hiki iaʻu ke hoʻololi i ka Atorvastatin me Rosuvastatin?

Inā hōʻole ʻole ka lāʻau lapaʻau, ka mea i hōʻike ʻia e nā hopena maikaʻi ʻole o ka ate, i hōʻoia ʻia e ka hōʻino ʻana o nā ʻāpana laboratorium, pono ia e hoʻoponopono i ka hoʻoponopono ʻia o ka hopena Atorvastatin: kāpae iki ka manawa, hoʻemi i ka dosage a i ʻole hiki iā ʻoe ke loli me ka Rosuvastatin hou.

ʻAʻole hiki iā ʻoe ke hana i kāu iho, no ka mea ma waena o 2 mau hebedoma a pau ke hoʻopaʻa ʻia ʻana o ka lāʻau, hoʻihoʻi ka pae o nā lipids i ke koko i kāna waiwai kumu ʻole, hiki ke hōʻeha nui i ke olakino maʻi. No laila, ʻo ke hoʻoholo i ka hiki o ke kahuli e pono ke lawe pū me ke kauka.

ʻO nā lāʻau maikaʻi loa o ka hanauna 3 a me ka 4

Ma luna o ke kūʻai lāʻau lapaʻau, hoʻonaʻau ʻia nā statins o ka hanauna a III a me IV e nā lāʻau lapaʻau mua - Liprimar (atorvastatin) a me Krestor (rosuvastatin), a me nā kope like, nā mea i kapa ʻia. nā generics i haku ʻia mai ka huahana like ʻole, akā ma lalo o kahi inoa ʻē aʻe (INN):

• atorvastatin - Tulip, Atomax, Liptonorm, Torvakard, Atoris, Atorvastatin,
• rosuvastatin - Roxer, Rosucard, Mertenil, Rosulip, Lipoprime, Rosart.

Hoʻohālike like ka hana o ka generics me ka mea maoli, no laila he kuleana kekahi i ke koho pono iā ia iho, ma muli o nā makemake pilikino.

He mea pono ke hoʻomaopopo i ka hiki ʻole o ka Atorvastatin a me Rosuvastatin, ʻaʻole like ka mea like, pono kā lākou huina i ka hopena like: e nānā pono i nā kūlana olakino o ke akeʻa a me nā puʻupaʻa, ma mua a me ka wā e hiki mai ana, me ka nānā pono ʻana i ka regimen mālama i kuhikuhi ʻia e ke kauka, ka meaʻai ka hoʻoikaika kino.

E pili ana i nā statins

ʻOiai pili o kona inoa (simvastatin, rosuvastatin, atorvastatin), nā mākana āpau i like me nā hana o ke ʻano ma ke kino o ke kanaka.Hoʻopili kēia mau lāʻau i ka hoʻoneʻe o ka enzyme HMG-CoA, aia i loko o ka wahī o ke akeo a komo i loko o ke kāpili ʻana o ka cholesterol. Eia kekahi, ke kāohi wale nei i kēia enzyme e alakaʻi wale nei i ka emi ʻana o ke kolamu o ke koko, akā e hoʻohaʻahaʻa ana i ka nui o nā lipoproteins density haʻahaʻa a haʻahaʻa loa i loko o ia mea, e hoʻokō nei i nā hana koʻikoʻi i ka hoʻomohala ʻana i ka atherosclerosis vascular.

I ka manawa like, ʻo ka kikoʻī o ka lipoproteins density kiʻekiʻe (HDL) i ka nui o ke koko, e hoʻoneʻe ana i nā lipids mai nā atherosclerotic plaque a kaʻa ka mea i ka ate, kahi e hoʻohemo ai i kahi hōʻemi o ka atherosclerosis a me kahi hoʻomaikaʻi i ka mālama pono o ka mea maʻi.

Aia nā 3 mau statins i nā hana lapaʻau hou o kēia wā: rosuvastatin, atorvastatin a me simvastatin.

Ma kahi o kona hopena pololei i ka protein metabolism i loko o ke kino, ke loaʻa nei nā statins i ka waiwai maʻamau: hoʻomaikaʻi lākou i ke kūlana o ka paia o loko o nā kīʻaha koko, a laila e hoʻēmi ana i ka hopena o kahi kaʻina o ke kaʻina atherosclerotic i loko o lākou.

Atorvastatin - kahi hui lipid-hoʻokuʻu

Hoʻohana ʻia ʻo Atorvastatin a me rosuvastatin e mālama i kekahi ʻano e pili ana i ka hypercholesterolemia (hoʻoilina a loaʻa), me ka kaʻi ʻana o nā maʻi like me ka myocardial infarction a me ka ischemic stroke. Eia nō naʻe, he nui nā mea maʻi a me nā kauka e nīnau i kahi nīnau koʻikoʻi, akā ʻo wai ka mea maikaʻi aʻe - rosuvastatin a atorvastatin? I mea e hāʻawi ai i kahi pane kūpono, pono e kūkākūkā i nā ʻokoʻa āpau ma waena o lākou.

ʻO ka ʻano hana a me nā ʻano o nā mea hoʻohui

He ʻokoʻa nā punika a me ke ʻano kūlohelohe - hiki ke hoʻopilikia i kā lākou lāʻau lapaʻau a me ka pono i ka mea maʻi. ʻO nā lāʻau lapaʻau kūlohelohe, e like me simvastatin, ʻokoʻa i kā lākou synthetic analogues i ka hana hōʻemi a hopena pinepine i nā hopena ʻaoʻao. Ma hope o nā mea āpau, ʻo ke kiʻekiʻe o ka hoʻomaʻemaʻe ʻana i ka hānai e pono ai nā kūlana o ka ʻoluʻolu.

Rosuvastatin ua contraindicated i nā maʻi me nā maʻi maʻa ikaika

Loaʻa nā statins syntnt (mertenyl - ka inoa kālepa no ka rosuvastatin a me ka atorvastatin) i loaʻa i ka hana kūleʻa i nā moʻomeheu kūikawā. Eia kekahi, ʻo ka huahana hopena i hōʻike ʻia e kahi kiʻekiʻe o ka hoʻomaʻemaʻe, e hana maikaʻi ana ma mua o nā mea kūlohelohe maoli.

I kahi hihia e pono ai ʻoe e lawe i nā statins ma kāu iho, ma muli o ka piʻi nui o nā hopena ʻaoʻao me nā hewa hewa.

A ʻoi aku ka ʻokoʻa i ka hoʻohālikelike ʻana i ka rosuvastatin a me ka atorvastatin ko lākou mau ʻano physicochemical, ʻo ia hoʻi ka solubility i nā momona a me ka wai. ʻO Rosuvastatin ka nui o ka hydrophilic a maʻalahi i ka hoʻokahe i ka plasma koko a me nā waiola ʻē aʻe. Atorvastatin, ma kahi ʻē aʻe, ʻoi aku ka nui lipophilic, i.e. hōʻike i ka hoʻonui ʻia ʻana o ka momona i loko. ʻO ka ʻokoʻa i kēia mau waiwai ka mea i mahele ai i nā hopena o nā ʻaoʻao. Ua loaʻa i ka Rosuvastatin ka hopena maikaʻi loa i nā pūpū o nā leʻaleʻa, a me kona huakini lipophilic, ma nā hana o ka lolo.

Ma muli o ke kaila a me ka hoʻomaka ʻana o nā lāʻau ʻelua, ʻaʻole hiki ke maopopo e ʻae like ka maikaʻi o lākou. I keia mea, pono e makaʻala i ka mea ʻokoʻa a lākou ʻē aʻe i kēlā me kēia i ke ʻano o ka pā a me ke kaʻi ʻana a me ka puʻupuʻu i ke kino, a me ke ka hopena o kā lākou hopena ma ka kolamu a me nā lipoproteins o nā ʻano like ʻole.

Nā ʻokoʻa i ka hana o ke kīnā, hoʻoulu a me ka ʻoki mai ke kino

ʻO nā ʻokoʻa ma waena o nā lāʻau ʻelua e hoʻomaka i ke kahua o ka homaʻi mai ka ʻōpū. ʻAʻole pono e lawe i ka Atorvastatin i ka manawa like me ka meaʻai, ʻoiai ua hoʻemi nui ʻia ka hapa o kona kūwaha. Ma ka huli ʻana, ua hoʻopili ʻia ka rosuvastatin ma ke ʻano maʻamau, me ka ʻole o ka hoʻohana ʻana i nā huahana like ʻole.

ʻO nā ʻokoʻa ma waena o nā lāʻau lapaʻau e pili ana i nā hōʻailona a me nā contraindications i kā lākou papa lāʻau.

ʻO ka mea nui e hoʻokaʻawale ai nā lāʻau i ko lākou metabolism, i.e. hakahaka i loko o ke kino kanaka. Hoʻololi ʻia ka Atorvastatin i kahi ʻano hana ʻole e nā enzyme kūikawā i loko o ke akeʻa mai ka ʻohana CYP. Ma kēiaʻano, pili nā hoʻololi nui i kāna hana me ka mokuʻāina o kēia ʻano maʻi hepatic a me ka hoʻohana ʻana i nā lāʻau ʻē aʻe e pili ana i ka paʻahana. I kēia hihia, ʻo ka ala nui o ka excretion o ka lāʻau pili me ka excretion me ka bile. ʻO Rosuvastatin a i ʻole mertenyl, kahi kūʻokoʻa, hoʻokuʻu nui ʻia me nā feces i kahi ʻano like ʻole.

ʻO kēia mau lāʻau maikaʻi ke koho maikaʻi no ka mālama lōʻihi o ka hypercholesterolemia, ʻoiai ke kamaʻāina nei lākou i ke koko e ʻae iā ʻoe e lawe i nā lāʻau i hoʻokahi manawa wale nō i ka lā.

ʻO nā ʻokoʻa ʻokoʻa

ʻO ka mea nui e koho ai i ka lāʻau lapaʻau kūikawā, ʻo ia kona pono, i.e. ka palena o ka hōʻemi o ka neʻe o ka kolamu a me ka lipoproteins haʻahaʻa haʻahaʻa (LDL) a me ka hoʻonui ʻana o ka lipoproteins density kiʻekiʻe (HDL).

Mertenil - kahi lāʻau lapaʻau synthetic

Ke hoʻohālikelike nei i ka rosuvastatin me ka atorvastatin i nā hoʻokolohua hoʻokolohua, ʻoi aku ka maikaʻi o ka mea mua. Hoʻopili mākou i nā hopena ma nā kikoʻī hou aku:

• Hoʻopili ʻo Rosuvastatin i ka LDL e ka 10% ʻoi aku ka maikaʻi ma mua o kona counterpart ma kahi kaulike like ʻole, hiki ke hana i ka mālama ʻana o nā mea maʻi me ka hoʻonui i hoʻonui ʻia i ka cholesterol.
• ʻO ka hewa a me ka make ma waena o nā mea maʻi e lawe nei i kēia mau lāʻau - he mea nui nō hoʻi - ka ulu ʻana o ka puʻuwai a me nā maʻi vascular, a me ka make ma ke ʻano o ka make ma nā kānaka e hoʻohana ana i ka mertenyl.
• ʻAʻole i ʻokoʻa ʻē ka mea i loaʻa i nā hopena ʻokoʻa ma waena o nā lāʻau ʻelua.

Hōʻike nā ʻikepili i loaʻa ka rosuvastatin i ʻoi aku ka maikaʻi o ka hoʻokaʻawale ʻana o ka HMG-CoA i loko o nā ʻāpana o ka puʻuwai, e alakaʻi ai i ka hopena therapeutic i hoʻohālikelike ʻia i ka atorvastatin. Eia naʻe, hiki i kona kumukūʻai ke lilo i mea koʻikoʻi no ke koho ʻana i kahi lāʻau lapaʻau kūikawā, pono e noʻonoʻo pono e ke kauka hele mai.

ʻOkoʻa ka liʻiliʻi ʻo Atorvastatin a me ka rosuvastatin, akā naʻe i ka hopena ʻē aʻe o ka hopena ʻeha a me nā ʻokoʻa i nā hopena ʻokoʻa, pono e noʻonoʻo ia i ka wā e kuhikuhi ai i ka mālama ʻana i kahi maʻi maʻi. Ma ka hoʻomaopopo ʻana i ke kauka e komo ana a me ka hoʻomanawanui o ka ʻokoʻa ma waena o nā statins hiki ke hoʻonui i ka pono a me ka palekana o ka lāʻau hypocholesterolemic therapy.