Pehea e hoʻohana ai i ka lāʻau lapaʻau Katena?

Me ka hoʻohana pinepine ʻana o ka gabapentin a me ka morphine, i ka manawa i lawe ʻia ai ka morphine i 2 mau hola ma mua o ka lawe ʻana i ka gabapentin, he nui ka hoʻonui ʻana o ka wahi ma lalo o ka pāpaʻi pharmacokinetic "ka hopena - manawa" (AUC) o gabapentin e 44% hoʻohālikelike me ka gabapentin monotherapy, ka mea i hoʻopili ʻia me ka hoʻonui ʻana i ka paepae ʻeha. hoʻākoʻokeʻo kikowaena hōʻike hōʻike). ʻAʻole paʻa i ke koʻikoʻi kauka o kēia hoʻololi; ʻaʻole i loli nā hiʻohiʻona pharmacokinetic o morphine. ʻO nā hopena ʻaoʻao o ka morphine i ka wā i lawe pū ʻia me gabapentin ʻaʻole i ʻokoʻa i ka poʻe ke lawe i ka morphine i hui pū me ka placebo.
ʻAʻole i ʻike ʻia ka pilina ma waena o gabapentin a me phenobarbital, phenytoin, waikawa valproic a me ka carbamazepine. ʻO nā pharmacokinetics o gabapentin i ka equilibrium e like me ka poʻe olakino a me nā mea maʻi e loaʻa ana i nā anticonvulsants.
ʻO ka hoʻohana like ʻana o ka gabapentin me nā ʻōlelo kūloko i loaʻa i ka norethisterone a me / a me ethinyl estradiol ʻaʻole i hoʻopili ʻia e nā loli me ka pharmacokinetics o nā mea ʻelua.
ʻO ka hoʻohana like ʻana o ka gabapentin me nā antacids e loaʻa ana i ka alumini a me ka magnesium i ukali ʻia me ka hoʻēmi ʻana i ka bioavailability o gabapentin e pili ana i 20%.
Noi ʻia ʻo Gabapentin e lawe ʻia aku ai ma kahi o 2 mau hola ma hope o ka lawe antacid.
ʻAʻole pili ʻo Probenecid i ka exal i hoʻopalau a gabapentin.
ʻO ka liʻiliʻi ʻokoʻa ma ka renal excretion o gabapentin ʻoiai
lawe cimetidine i loaʻa ʻole koʻikoʻi kauka.

Nā ʻōlelo kikoʻī

Me ka hui pū ʻana me ka morphine, hiki ke hoʻonui ʻia i ka ʻike o ka gabapentin i nā maʻi. I kēia hihia, pono e nānā pono i nā poʻe maʻi no ka hoʻomohala ʻana i kahi hōʻailona o ka minamina o ka pūnao nū nui (CNS) me ka hiamoe. I kēia hihia, pono ke hoʻohaʻahaʻa ʻia ka nui o ka gabapentin a i ʻole morphine (e nānā i "Interaction with other drug").
Pūnaewele noiʻi

Me ka hoʻohana pū ʻana o gabapentin a me nā anticonvulsants ʻē aʻe, ua hoʻopaʻa ʻia nā hopena maikaʻi ʻole i ka hoʻoholo ʻana o ka protein i ka urine me ka hoʻohana ʻana i nā palapala hōʻike ʻo Ames N-Multistix SG®. I mea e hoʻoholo ai i ka protein i ka urine, ua ʻoi ʻia e hoʻohana i kahi ʻano ʻoi aku ka nui o ka ua me ka acid o ka sulfosalicylic.

Hoʻomaopopo i ka hiki ke alakaʻi i nā kaʻa a me nā ʻenehana

Wahi a nā hopena o nā haʻawina ʻoihana maʻi, ua manaʻoʻiʻo ʻia ka hopena o ka betahistine ma ka hiki ke ke kaʻa i ka kaʻa a me nā ʻano hana ʻē aʻe ua hemahema a kī ʻole ʻole, no ka mea, ʻaʻole i ʻike ʻia ka hopena.

E hoʻokuʻu i ke ʻano

Kapuai 100 mg, 300 mg, 400 mg.
Nā Capsules 100 mg: 10 mau kalapona ma ka pōpoki PVC / Al. Ua hoʻonoho ʻia nā blisters ʻelua me nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana ma kahi pahu pahu.
Nā Capsules 300 mg a me 400 mg: 10 mau poli i loko o PVC / Al blister. Hoʻokomo ʻia nā blisters ʻelima me nā kauoha no ka hoʻohana ʻana i kahi pahu kāleka.

Nā hōʻailona no ka hoʻohana ʻana

Epilepsy: kahakaha mahele me ka nui ʻole o ka hana kiʻekiʻe ma ka pākeke a me nā keiki ma mua o 12 mau makahiki (monotherapy), ʻāpana o ka hakahaka me ka loaʻa ʻole o ka hoʻomohala lua ʻana i nā pākeke (nā lāʻau lapaʻau hou), ke ʻano pale o ka epilepsy i nā keiki i ʻoi aku ma mua o 3 mau makahiki (mau lāʻau hou).

ʻO ka maʻi Neuropathic i nā maʻi ma mua o nā makahiki 18.

Pehea e hoʻohana ai: dosis a me ke ʻano o ka mālama ʻana

I loko, e pili ʻole i ka ʻahaʻaina.

Epilepia ʻO nā pākeke a me nā keiki ma mua o nā makahiki he 12: ʻo ka hopena mua o Katena ʻo 300 mg 3 mau manawa i ka lā ma ka lā mua, ʻo ka hopena kūpono ʻo 900-3600 mg / lā. ʻO ka nui loa o ka lā helu he 3600 mg (no nā pākēnē 3 like). ʻO ka lōʻihi loa ma waena o nā pona i ka wā e kuhikuhi ai i ka lāʻau lapaʻau 3 mau manawa i ka lā ʻaʻole e ʻoi aku ma mua o 12 mau hola.

Hiki ke koho ʻia e like me ke ʻano o kēia i kēia (hiki ke loaʻa i ke ʻano. I ka pāʻana o 900 mg: ma ka lā mua - 300 mg 1 mau lā i ka lā, ma ka lua - 300 mg 2 mau manawa i ka lā, ma ke kolu - 300 mg 3 mau manawa i ka lā, ma kahi lemona o 1200 mg: 400 mg 1 mau lā i ka lā, 400 mg 2 mau manawa i ka lā, 400 mg 3 mau lā i ka lā ma ka lā mua, ka lua a me ke kolu, kēlā.

ʻO nā keiki i hala he 3-12 mau makahiki: ka hopena kūpono - 25-35 mg / kg / lā ma 3 mau kīnā. Hiki iā ʻoe ke koho i ka maʻa i ka hopena i loko o nā lā 3: 10 mg / kg / lā ma ka lā mua, 20 mg / kg / lā ma ka lua a me 30 mg / kg / lā ma ke kolu. Ma kahi noiʻi lōʻihi lōʻihi, ʻoi ka mālama ʻana i ka lāʻau ma nā inika a hiki i ka 40-50 mg / kg / lā he maikaʻi.

Hiki iā ia ke hoʻohana i ka hana: me ka paona o ke kino o 17-25 kg - 600 mg / lā, kēlā me kēia, me 26-36 kg - 900 mg / lā, me 37-50 kg - 1200 mg / lā, me 51-72 kg - 1800 mg / lā . ^ E Ha yM.

ʻO ka Neuropathy ma nā pākeke: ʻo ka inamua mua o Katena ʻo 300 mg 3 mau manawa i ka lā, inā pono, e hoʻonui pinepine ʻia ka pākaʻi me 3600 mg / lā.

ʻO ka mea maʻi me ka hana renal impaired: me CC ma mua o 60 ml / min - 400 mg 3 mau manawa i ka lā, me CC mai 30 a 60 ml / min - 300 mg 2 mau lā i ka lā, me CC mai 15 a 30 ml / min - 300 mg 1 mau lā i ka lā, me CC ma lalo o 15 ml / min - 300 mg i kēlā me kēia lā.

Ke kauoha ʻia nei e loaʻa i nā maʻi i ka hemodialysis i loaʻa ʻole i ka gabapentin i loko o kahi wai hoʻomehana ʻo 300-400 mg, a laila 200-300 mg i kēlā me kēia mau hola 4 o hemodialysis.

Hoike ʻike

Hōʻike pū ʻia ka Epilepsy e nā neʻe maʻamau a i ʻole nā ​​hemahema o ka ʻike (somnambulism, twilight dizziness, trance). Eia kekahi, ua nānā ʻia kēia maʻi e ka ulu lohi ʻana o nā loli kanaka a me ka dementia epileptic. ʻO kekahi manawa hōʻike kēia maʻi maʻi i ka ʻano o nā psychoses e hele mai ana i loko o kahiʻeha a me ke ʻano maʻi. Hiki iā lākou ke ukana me nā maʻi like ʻole e like me ka laʻa, ka makaʻu, ka huhū, ke kaumaha, ka makemake nui, ke ʻano kiʻekiʻe, ka leʻaleʻa, ka leʻaleʻa.

Ma ka hanana e ulu ana ka hanana o ka epileptic seizure ma muli o nā patology somatic, a laila ʻōlelo lākou i ka epilepsy hōʻailona.

Ma nā lāʻau lapaʻau, ʻike pinepine lākou i ka mea i kapa ʻia he epilepsy temporal. Kahi manaʻo kūloko e pili ana i kēia kūlana i kū hoʻokahi ʻia i ka limu kino o ka lolo.

Hiki ke ho'ōla ʻia ka epilepsy? Lawe ʻia nā maʻi a me ka hoʻomohala ʻana o kēia maʻi ma ka epileptologists a me nā neurologists. Ua ʻōlelo nā poʻe loea ʻaʻole hiki ke hoʻopau loa i kēia ʻano. Eia nō naʻe, aia kekahi mau lāʻau liʻiliʻi e hiki ai ke pale i ka ʻeha neuropathic a hoʻomaikaʻi i ka maikaʻi o ka mea maʻi. ʻO kekahi lāʻau lapaʻau ʻo Katena (300 mg). Hōʻike ʻia nā ʻōlelo aʻoaʻo, nā loiloi, nā analogues a me nā hiʻohiʻona ʻē aʻe o kēia mea hana ma lalo nei.

Hoʻohui, kāpili a hoʻokuʻu i ke ʻano

Ma ke ʻano hea ka kūʻai ʻana o ka lāʻau Katena? Hōʻike nā loiloi o nā mea maʻi e loaʻa ana kahi ʻano hana i loko o nā mea i loko o nā mea lapaʻau i ke ʻano o nā capsules.

ʻOkoʻa paha ka hewa o ka lāʻau lapaʻau i ka nīnau. He keʻokeʻo ka 100 mg mau pihi (ʻAʻohe 3 mau) ka ʻulaʻula, 300 mg (ʻokoʻa. 1 nui) ka melemele, a ʻo 400 mg (ʻAʻohe 0 nui) ka ʻāpana.

ʻO nā mea o ka lāʻau lapaʻau ka puʻupuʻu keʻokeʻo keʻokeʻo.

Hoʻokomo ʻia nā Capsules i nā poli a me nā paʻi pepa, i kēlā

He aha ka mea kanu ikaika i ka lāʻau Katena? Hōʻike nā loiloi o nā loea e pili ana i ka hana kiʻekiʻe o kēia lāʻau lapaʻau e pili pono ana me kāna kumu hana koʻikoʻi - gabapentin. Eia kekahi, ka hoʻonohonohoʻana o ka mea hoʻopili ma lalo o ka noʻonoʻo e pili ana i nā kumuhana like e like me ka palaoa st, talc a me ka lactose monohydrate.

ʻO nā pōkole capsule o nā capsules, he gelula, titanium dioxide (E171) a me ka palanikena mea hao i ka hao a me ka ʻulaʻula.

Ka hana lāʻau lapaʻau

Pehea ka hana a antiepileptic e like me Katena e hana ai? ʻO nā loiloi o nā mea loea, a me nā ʻōlelo pili i kau ʻia ka ʻike i ka hiki ke mālama ʻia ʻana o ka lāʻau lapaʻau ma muli o ka gabapentin i loko o ia mea, ʻo ia hoʻi, he ʻano like i loko o ke ʻano o ka neurotransmitter GABA a i ʻole ka mea i kapa ʻia gamma-aminobutyric acid. Eia nō naʻe, pono e hoʻomaopopo i ka ʻano o ka hana o kēia lāʻau lapaʻau ka mea like me ka manaʻo o nā lāʻau ʻē aʻe e pili pū ana me nā ʻĀpana GABA.

E like me nā ʻōlelo kuhikuhi, hiki i ka gabapentin ke hoʻopili i ka subunit α2-δ o nā kaila calcium kūʻokoʻa, a ke kāohi nei hoʻi i ke kahe o nā wai Ca, ʻo ia kekahi o nā kumu o ka ʻeha neuropathic.

Mau waiwai

No ke aha ke kaulana nui o Katena? Hōʻike nā loiloi o nā kauka a me nā mea maʻi e lawe nui ana i kēia lāʻau lapaʻau i ka kūlana maʻamau o ka mea maʻi. ʻO kēia ke kumu o ka loaʻa ʻana o ka mamae neuropathic, ʻo ka hoʻolaʻa ikaika o ka lāʻau hiki ke hōʻemi i ka make glutamate-hilinaʻi o nā ona sela, hoʻonui i ka synthesis GABA, a pale pū hoʻi i ka hoʻokuʻu ʻana o ka neurotransmitters pili i ka hui monoamine.

I nā kūmole therapeutic, ʻo ka lālani i nīnau ʻia ʻaʻole i hoʻopaʻa ʻia i nā mea hoʻokae neurotransmitter, e komo pū ai me nā benzodiazepine, glutamate, N-methyl-D-aspartate, glycine, GABAA a me GABAA receptor. ʻAʻole i like nā lāʻau e like me Carbamazepine a me Phenytoin, ʻo Katena (nā loiloi ma lalo nei) ʻaʻole i pili me nā kahawai Na.

Nā hiʻohiʻona Pharmacokinetic

Ua hoʻokomoʻia nā mea ikaika o Catena (300 mg)? Hōʻike nā ʻōlelo a me nā loiloi loea e kahili ʻia nā gabapentin mai ka papalihi ʻana.

Ma hope o ka hoʻoponopono waha ʻana i nā capsules, ʻo ka piʻi ʻana o ka nui o ka nui o ka wai o ka wai i loko o ke koko a hōʻea ma hope o 3 mau hola.ʻO ka bioavailability kūpono o ka lāʻau e pili ana i ka 60%. ʻO ka ʻaihue ulu o ka ʻai (me nā meaʻai me nā momona momona) ʻaʻohe hopena i nā hiʻohiʻona pharmacokinetic o gabapentin.

ʻAʻole ka mea paʻa i ka lāʻau lapaʻau e pale i nā protein plasma. I ka poʻe maʻi me ka epilepsy, ʻo kona ʻike ʻana i ka wai o cerebrospinal ma kahi o 20% o nā mea i loko o ka plasma.

Hoʻomaka ʻia ka kū hoʻokahi o ka gabapentin ma o ka ʻōnaehana renal. ʻAʻole ʻike ʻia nā hōʻailona o ka loli olakino o kēia ʻāpana i ke kino o ke kanaka. ʻAʻole hiki i Gabapentin ke hoʻonāukiuki i nā oxidases, ka mea i komo i ka metabolism o nā lāʻau ʻē aʻe.

ʻO ka hoʻihoʻiʻana o ka lāʻau lapaʻau ka laina. ʻO ka hapalua hapalua o kona ola, ʻaʻole ia e hilinaʻi i ka nui o nā kiʻi i lawe ʻia a ma kahi paha o 5-7 mau hola.

Hoʻopili ʻia ka hoʻopiʻi ʻana o Gabapentin ma ka poʻe elemakule, ʻo ia hoʻi i nā mea maʻi me ka hana renal impaired. Hoʻokuʻu ʻia ka mea ikaika o ka lāʻau mai ke koko i ka wā hemodialysis. ʻO nā kukuna o ka plasma o ka gabapentin i nā keiki he like ia me nā mea pākeke.

Nā hōʻailona no ka lawe ʻana i nā capsules

I nā kūlana e hiki ai i kahi maʻi ke kuhikuhi i ka lāʻau lapaʻau e like me Katena (300 mg)? Hōʻike nā ʻōlelo a me nā loiloi e hōʻike ʻia ana nā ʻano ʻōlelo i like me ke hoʻohana ʻana i nā lāʻau lapaʻau i haʻi ʻia.

• ʻeha nā neuropathic i nā maʻi maʻi makua,
• nā mākana wahi (me nā kūlana me ka hoʻonui ʻana i ka lua) i nā ʻōpio mai nā makahiki 12 a me nā pākeke (ma monotherapy),
• kahi māhu wahi (me nā kūlana me ka hoʻonui ʻana i ka lua) i nā keiki mai 3 mau makahiki a ʻo nā pākeke (ma ke ʻano he lāʻau lapaʻau hou ma ke ʻano o ka mālama paʻakikī).

Nā hoʻohalike e lawe i nā capsules

Ahea oe aole e lawe i Katena? Nā hōʻike a me nā loiloi e hōʻike ikaika ʻia ana nā lāʻau lapaʻau i nā keiki ma lalo o 3 mau makahiki o ka makahiki. Ua papa ʻia nō hoʻi no ka hoʻohana ʻana i ka wā e nānā ana i ka mea maʻi me ka ʻike kiʻekiʻe i nā mea o ka lāʻau.

Me ka makaʻala koʻikoʻi, hāʻawi ʻia ka lāʻau lapaʻau i nā poʻe me ka loaʻa ʻole o ka pale.

Keʻano "Catena": kuhikuhi i ka hoʻohana

ʻO nā loiloi o nā mea loea a me nā kuhikuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau i ka nīnau he hopena maikaʻi loa a he kaulana antiepileptic. Kuhi ʻia i loko o ka ʻae ʻia me ka ʻole o ka ʻahaʻaina. Hoʻemi i ka dosage, hoʻopau i ka lāʻau lapaʻau, a i ʻole e hoʻololi hou i kahi mea lapaʻau hou aʻe, e hoʻopau iki i hoʻokahi hebedoma.

Me ka eha neuropathic, ʻo ka lāʻau mua o kēlā me kēia lā o ka lāʻau (i nā pākeke) pono ʻo 900 mg (i ʻekolu mau helu). Inā lawa ka hopena i loaʻa, a laila e hoʻonui mālie ka dosage.

ʻO ka lōʻihi loa o ka lā helu o Katena he 3600 mg.

ʻAʻole pono ʻoi aku ka manawa ma waena o ka hoʻokele capsule ma mua o nā hola 12, no ka mea aia ke kiʻekiʻe o ka hana hou ʻana o nā waiwai.

Me ka hoʻomohala ʻana i ka ʻaha wahi puʻuwai i nā keiki 3-12 mau makahiki, ke kuhikuhi ʻia nei ka lāʻau lapaʻau ma ka inika mua o 10-15 mg / kg (mahele ʻia i 3 mau pona). Ma luna o 3 mau lā, e hoʻonui mālie ka dosage (i ka ʻoi aʻe ka hopena).

He aha kāu e pono ai e ʻike ma mua o ka hoʻomaka ʻana e lawe iā Catena? Wahi a nā poʻe loea, ʻaʻole pono pono e nānā i ka paʻa o kēia lāʻau lapaʻau i ka wā o ka mālama ʻana. Hiki ke hoʻohana ʻia ka lāʻau lapaʻau i ka hoʻohui me nā anticonvulsants ʻē aʻe.

Nā hopena hopena

He aha nā hopena e hiki ke hōʻeha i kahi lāʻau lapaʻau Katena (300 mg)? Hōʻike ʻia nā loiloi ma hope o ka lawe ʻana i kēia lāʻau lapaʻau, hiki nō ke hoʻomohala i kēia mau ʻano aʻe (hoʻokahi a ʻoi aku paha ma ka manawa like).

• amnesia, leukopenia, rhinitis, ataxia, pneumonia, confing, bone fractures, impaired coordination o ka neʻe, ka ʻōpū, ke kaumaha, pharyngitis,
• purpura thrombocytopenic, dizziness, diarrhea, dysarthria, hōʻemi ʻia ka nui o ke koko keʻokeʻo, hoʻonui i ka huhū o ka huhū, arthralgia, nystagmus, myalgia,
• ka ʻeha, ke kūpeʻe ʻana mai o ka maʻi, ka noʻonoʻo ʻole, ka hōʻike ʻana o ka vasodilation, nā pā, ka maʻi o ka maʻi urinary, nā kīwaha, ka honi, amblyopia, maceration o ka ʻili, ka diplopia, ʻeha
• hyperkinesia, ʻaeʻeha, hoʻoikaika / hoʻonaninani / kahu ʻole o nā reflexes, hypertension arterial, paresthesia, Stevens-Johnson syndrome, hopohopo, impotence, hoʻāla, erythema multiforme, ʻeha huakaʻi, ʻeha hope,
• loli i ka mālama ʻana o ka niho, ka luhi, ka nui ʻana o ka makemake, ka huehue o ka maka, ka malo maloʻo, asenaiia, nausea, ke kaupaona ʻana, ka huhū, ka trauma hōʻeha, ka uluwale,
• anorexia, peripheral edema, gingivitis, flu-like syndrome, ʻeha ʻeha, fluctuations i ke kulana o ka glucose koko, maʻi ʻona, otitis media, pancreatitis, asthenia, hoʻololi i nā maʻi hana ʻehaʻeha, mahele ʻale.

Hoʻohui nūhou

Hiki iaʻu ke lawe i nā kapena Katena me nā lāʻau ʻē aʻe? Hōʻike nā loiloi o ka poʻe loea i ka wā e lawe nei i kēia lāʻau lapaʻau me nā antacids, ua hoʻemi ʻia ka pilina o ka gabapentin mai ka digestive tract.

Ke hoʻohana ʻia nei me Felbamate, hiki i ka hapalua o ke ola o ka hope.

He mea nui ia e ʻike!

ʻO ka hoʻopau pinepine ʻana o ka mālama anticonvulsant i ka poʻe me nā māka ʻāpana me ke kūpaʻa i ka hoʻomohala ʻana i ke kūlana hoʻomālamalama. No laila, inā pono e hoʻemi i ka ʻai, hoʻokaʻawale i ka gabapentin a i ʻole ke hoʻololi i ka lāʻau lapaʻau e hoʻokaʻawale, pono e hana ʻia i kēia mau hebedoma, ma hoʻokahi pule.

ʻAʻole ʻoi ʻia nā Capsules "Katena" i kahi mea kūpono no ka mālama ʻana i nā mea hoʻokūkū hoʻokūkū.

Ka hana like ʻole o ka lāʻau i haʻi ʻia me nā lāʻau anticonvulsant e hōʻike pinepine i nā hopena maikaʻi ʻole o ka hoʻokolohua, ka mea i hana ʻia e hoʻoholo ai i ka palaki i loko o ka urine. No laila, i ka wā e hoʻolako ʻia ai e hoʻohana i kahi ʻano ʻoi aku ka nui o ka ua ʻana o ka waikona sulfosalicylic.

ʻO ka poʻe me ka hana renal lēwa, a me nā mea ma ka hemodialysis, pono e hoʻoponopono i ka regimen dosage.

Hiki i nā ʻōpio kahiko ke hoʻolōʻihi i ka nui o ka lāʻau, no ka mea i loko o kēia ʻano maʻi i nā maʻi e hōʻemi i ka wehe ʻana i nā mea wehe.

ʻO ka palekana a me ka hana pono o ka hopena o ka epilepsy me ke kōkua o ka lāʻau ʻo Katen i nā maʻi ʻōpiopio, ʻo ia hoʻi i nā keiki ma lalo o 12 makahiki o ke kūpaʻa, ʻaʻole i hoʻokumu.

I ka wā o ka mālama ʻana me ia lāʻau lapaʻau, pāpā ʻia ka waiʻona.

ʻO ka lāʻau "Catena": loiloi o nā kauka a me nā mea maʻi, nā mea hoʻohālike

ʻO nā hui like o ka lāʻau lapaʻau e nīnau ʻia ana: Eplirintin, Gabagamma, Gabapentin, Neurontin, Tebantin, Konvalis, Egipentin.

Wahi a nā poʻe loea, ʻo ka lāʻau lapaʻo Katena kahi lāʻau lapaʻau antiepileptic maikaʻi loa, mahalo maoli ʻia i nā poʻe i loaʻa pinepine i ka neʻe a me ka lawe ʻana i ka wā eiplepsy. Nā maʻi maʻi, kākoʻo kā lākou i ka manaʻo o nā kauka.

Eia naʻe, ʻike pinepine nā loiloi i waena o nā loiloi maikaʻi. Wahi a ka hapa nui o nā mea maʻi, ʻo ka loaʻa nui o ka lāʻau lapaʻau ka nīnau nui he overpriced (hoʻohālikelike ʻia me nā lāʻau lapaʻau like). Ua ʻōlelo ʻo nā loea i ka lāʻau lapaʻau, ka mea ikaika o ka gabapentin, he nui nā contraindications e hoʻohana ai, a me nā hopena ʻoliʻoli i hōʻike ʻia e ka ʻōnaehana.

E hoʻokuʻu i nā palapala a me ka ʻano

Nui nā ʻano o nā capsules i ke kūʻai aku ʻia, e pili ana i nā kiko o ka mea hana - gabapentin (100 mg, 300 mg, 400 mg). Aia ka hopena i ka hopena kumu ma ke kumu nui o ka mamae neuropathic - ka kahe o nā kalona o nā calcium. Hoʻopau wikiwiki a hana maikaʻi i nā huhui a me nā hōʻailona ʻē aʻe o ka epilepsy.

ʻAoʻao no ka hoʻohana ʻana iā Catena: nā hewa a me nā lula no ka hoʻokomo ʻana

ʻAʻole ka hilinaʻi ʻo nā pilaleka e ʻai. Pono ʻoe e ʻae penei:

No ka hōʻeha o ka neuropathic, ʻo ka ʻōlelo i hāʻawi ʻia no ka poʻe maʻi ma mua o 12 mau makahiki he 300 mg ʻekolu mau manawa i ka lā. I kekahi mau manawa, ke hoʻonui ʻia ka hopena i 3600 mg / lā.

Me nā kahakaha puʻu, hōʻike ʻia nā mea maʻi mai nā makahiki 12 he lawe i ka 900-3600 mg / lā. Hiki ke hoʻomaka ka lāʻau lapaʻau me kahi liʻiliʻi liʻiliʻi o 300 mg ʻekolu mau manawa i ka lā. ʻO ka palena nui loa he 4800 mg / lā. No nā keiki mai 3 a 12 paha makahiki, hōʻemi ʻia ka nui o ka dosis a 10-15 mg / kg / lā. Pono e hoʻokaʻawale ʻia ka lawe ʻia ʻana ma 3 mau manawa. Hiki iā ʻoe ke hoʻonui mālie i ka dosage i 50 mg / kg / lā.

I ka wā mālama, ʻaʻohe mea pono e nānā i ka ʻike o ka mea hana i loko o ke koko. ʻAʻole koi ʻia ka hoʻoponopono hoʻoponopono ʻana i ka wā e hoʻohana ana i nā anticonvulsants.

Pharmacokinetics a me ka lāʻau lapaʻau

ʻO Katena kahi lāʻau lapaʻau anticonvulsant nona ka manaʻo e kāohi i ka hōʻeha ʻana i ka maʻi neuropathic. ʻO ka mea nui - ka gabapentin, kahi ʻāpana o ka huahana, e hana ana ma ke kahe o nā kaluna o ka calcium, ka mea e hoʻopili pololei ʻia i ka hopena o nā hōʻailona ʻeha neuropathic.

Ma muli o ka hopena o ka hana ikaika ma ke kino o ka mea maʻi, hoʻopiʻi, hōʻailona i nā hōʻailona o ka epilepsy a me nā ʻeha hōʻeha o ka ʻehaʻeha. Hoʻopau ʻia ka lāʻau lapaʻau ma o nā keiki.

No laila, ʻo ka lāʻau lapaʻau "Catana" kahi hopena analgesic, anticonvulsant a me anticonvulsant.

Nā hopena hopena

Nā maʻi maʻi: erythema multiforme, maʻi ʻo Stevens-Johnson.

• ʻO ka ʻeha o ka hope, ka luhi, ka edema peripheral, impotence, asthenia, malaise, ka hele ʻana o ka helehelena, ke kaupaona ʻana, ka trauma kūʻole, ka asiniaia, ka maʻi like-flu, nā huʻu i ka glucose koko, i nā keiki - kahi maʻi viral, otitis media.
• Mai ka pūnaehana cardiovascular: hypertension arterial, manifestations of vasodilation.
• Mai ka pūnaehana ʻana: hoʻololi i ka mālama ʻana o ka niho, ka ʻeha, ka nui o ka makemake, ka malo maloʻo, ka luaʻi, ka luaʻi ʻana, ka lemulima, anorexia, gingivitis, ʻeha o ka ʻōpū, pancreatitis, nā loli i nā hana hana ate.
• Mai ka pānaehana urinary: urinary tract infection, ka urinary incontinence.
• Mai ka papa musculoskeletal: myalgia, arthralgia, he iwi iwi.
• Nā hopena dermatological: maceration o ka ʻili, ka huehue, ke kau, ʻeha.
• Mai ka pūnaehana hemopoietic: leukopenia, hoʻemi ʻia ka helu sela ke keʻokeʻo, thrombocytopenic purpura.
• Mai ka papa hana hanu: rhinitis, pharyngitis, pūlapu, pneumonia.
• Mai ka ʻaoʻao o ka pūnaehana nīkini, a me nā ʻōnaehana hoʻoneʻe peralheral: amnesia, ataxia, confing, conclinical coordination of movement, depression, dizziness, dysarthria, meningkat nerve irritability, nystagmus, drowsiness, impaired thinking, tremors, convulsions, amblyopia, diplopia, hyperkinesia, worsening nele i nā pōkole, paresthesia, hopohopo, hoʻonāukiuki, hana lima.

ʻO nā keiki, i ka wā hāpai a me ka lactation

ʻAʻohe ʻikepili e pili ana i ka hoʻohana ʻana i ka lāʻau lapaʻau i nā wahine hāpai, no laila, pono ke hoʻohana ʻia ka gabapentin i ka wā hapai inā inā pono ka pōmaikaʻi ponoʻi i ka makuahine i hiki ke kūpono i ka maʻi iho.

Hoʻopili ʻia ʻo Gabapentin ma ka umauma umauma, ʻaʻole ʻike ʻia kona hopena i ka hānai hānai, no laila, i ka wā o ka mālama ʻana i ka hānai, pono e haʻalele ʻia ka mahi ʻana.

Nā Hoʻohui Kūʻai

I ka hihia hui pū ʻana o cimetidine, kahi liʻiliʻi iki o ka renal excretion o gabapentin hiki, akā hiki i kēia ʻano hanana kumu ʻona.

• ʻO nā antacids e loaʻa ai ka alumini a me ka magnesium i hōʻemi i ka bioavailability o ka gabapentin e ma kahi o 20%, no laila ke kuhikuhi nei e lawe i 2 mau hola ma hope o ka lawe ʻana i nā antacids.
• Ke hoʻohana ʻia nei nā contraceptives waha e loaʻa ai ka ethinyl estradiol a me / a i ʻole norethisterone, ʻaʻohe loli i ka pharmacokinetics o nā ʻāpana.
• ʻAʻohe hopena o Probenecid i ka ʻōkōkōna o ka hoʻoponopono o ka gabapentin.
• I ka mokuʻohalike, ʻaʻole e loli nei ka pharmacokinetics o gabapentin me ka hoʻohana pinepine ʻana i nā anticonvulsants ʻē aʻe.

ʻAʻohe mea i ʻike ʻia ma waena o gabapentin a me ka valproic acid, phenytoin, fenobarbital, carbamazepine.

Nā hiʻohiʻona noi

ʻO nā mea maʻi me ka maʻi maʻi e kipa aku i ke kauka e hoʻoponopono i ka nui o nā lāʻau lapaʻau hypoglycemic.

Ma ke ʻano o ka noi ʻana o Katen, pono ka mana o ka noho ʻana o ka maʻi o ka mea maʻi, no ka mea, hiki i ka lāʻau lapaʻau ke kumu i ka hoʻomohala ʻana o nā mea kaumaha a me ka suicidal mood.

He mea koʻikoʻi loa ia e nānā i ka hoʻoponopono ʻia o ka dosage i kuhikuhi ʻia e kāu kauka e pale i ka hopena o nā hopena ʻino. Hoʻopilikia paha ka hōʻino ʻana o ka lāʻau lapaʻau i kahi kūlana hoʻohewa. Inā pono e hōʻemi i ka hopena, pono ʻoe e ʻōlelo i ke kauka e hana i kahi hoʻolālā kūpono. ʻO ka mea maʻi e lawe ana i ka lāʻau lapaʻau, ʻaʻole i ʻōlelo ʻia e hoʻokele i nā kaʻa.

ʻO nā ʻano like

ʻO ka helu kikoʻī o Catena:

1. Hapentek
2. Egipentin
3. Convalis
4. Neurontin
5. Gabantine,
6. Katena
7. Eihapai,
8. Tebantin
9. Gabagamma

Kau ʻia nā lāʻau antiepileptic:

1. Hexamidine
2. Zeptol
3. Misolin,
4. Algerika
5. Pregabalin
6. Hōʻailona
7. Zonaola
8. Benzonal
9. Depakine
10. Hoolioli
11. Topiramat,
12. Kauleila
13. Carbamazepine
14. Gabitril
15. Finlepsin
16. ʻOnio,
17. ʻĀnipola
18. Kalaiwa
19. Relium
20. Eihapai,
21. Valopixim
22. Finlepsin Mahalo,
23. Primidon
24. Benzobarbital,
25. Lamictal
26. Haawe,
27. Wimpat,
28. Zagretol
29. Epimax
30. Suksilep
31. Acetazolamide,
32. Diphenin,
33. Paglüferal,
34. Phenobarbital,
35. Depakin Chrono
36. Na Depamide
37. Topamax
38. Lamitor,
39. Nā Lamotrigine
40. Convalis
41. Levetinol,
42. Convulsan
43. Prigabilon
44. Kāohi
45. Inovelon
46. Diacarb,
47. ʻO ka waikawa Valproic
48. Chloracon
49. Levetiracetam
50. ʻO Encorat
51. Clonazepam
52. Diazepam
53. ʻO Zenitsetam
54. Valparin
55. Trobalt.

Lapaʻau lāʻau

ʻO ka waiwai ikaika o Catena ʻo gabapentin, kahi mea like i ka pae ʻana i ke ʻano gamma-aminobutyric neurotransmitter (GABA). Eia nō naʻe, he ʻokoʻa ka ka mana o nā hana i ke ʻano o kekahi mau lāʻau ʻē aʻe e pili ana me nā ʻĀpana GABA, me ka barbiturates, GABA uptake inhibitors, GABA agonists, valproate, GABA transaminase inhibitors, benzodiazepines a me nā hua prodrug o GABA, no ka mea ʻaʻole GABAergic i ka gabapentin. waiwai, ʻaʻole i pili i ka metabolism a lawe pio o GABA.

Wahi a nā haʻawina mua, pili ʻo Gabapentin i α₂-δ-subunit o nā kaila calcium-hilinaʻi a hoʻohiolo i ke kahe o nā kaluna calcium, ʻo ia kekahi o nā kumu o ka hōʻeha o ka neuropathic.

Eia kekahi, me nā hōʻeha neuropathic, gabapentin i nā ʻano hana ʻē aʻe o ka hana, ʻo ia hoʻi: e hōʻemi ana i ka make o ka glutamate-dependence o nā neurons, hoʻonui i ka synthesis GABA a pale aku i ka hoʻokuʻu ʻana o ka neurotransmitters o ka hui monoamine.

I loko o nā kikowaena koʻikoʻi o nā maʻi, ʻaʻole i hoʻopaʻa ʻia ka lāʻau i nā mea nānā i nā lāʻau maʻamau a me nā neurotransmitters, e komo pū ana me benzodiazepines, glutamate, glycine, N-methyl-D-aspartate, GABA_A a me GABA_I.

ʻAʻole e like me carbamazepine a me ka phenytoin, ʻaʻole i pili ʻo gabapentin i nā ʻano sodium.

Nā ʻōkuhi no ka hoʻohana ʻana iā Katena: ʻano a me ka helu ʻana

Pono e lawe ʻia nā Kūpepa me ka ʻōlelo maʻamau, me ka ʻole o ka meaʻai. Hoʻemi i ka pauku, hoʻoneʻe iā Katena a hoʻololi paha me kahi mea hoʻohana hou aku e lilo lohi, ma ka liʻiliʻi hoʻokahi pule.

Me ka ʻeha neuropathic i nā pākeke, ʻo ka nui o ka lā ma mua o 900 mg - 300 mg 3 mau manawa i ka lā. Inā ʻaʻole pono ka hopena, e hoʻonui mālie ka hopena. ʻO ka pae ʻana ʻoi loa i kēlā me kēia lā he 3600 mg.

Hiki iā ʻoe ke hoʻomaka koke i ka hoʻōla me kahi maʻi o kēlā me kēia lā he 900 mg a e hoʻonui iki paha iā ia ma luna o nā lā ʻekolu mau lā e like me ke kumuhana ʻia:

• ka lā mua - 300 mg hoʻokahi i ka lā,
• ka lua o ka lā - 300 mg 2 mau manawa i ka lā,
• ka lā ʻekolu - 300 mg 3 mau lā i ka lā.

Me nā haʻalulu puʻuwai i nā pākeke a me nā ʻōpio mai nā makahiki he 12, ua ʻoiai ʻo Katena e whai pono i ka nui o nā helu o kēlā me kēia lā o 900-3600 mg.Hiki iā ʻoe ke hoʻomaka koke i ka mālama ʻana me kahi maʻi o kēlā me kēia lā he 900 mg (300 mg 3 mau manawa i ka lā) a i ʻole e hoʻonui ma luna o nā lā ʻekolu mau lā e like me ke kumu i hōʻike ʻia ma luna nei. I ka wā e hiki mai ana, inā hoʻomau, e hoʻomau i ka nui o ke koina, a hiki i ke koina lā nui o 3600 mg (ma nā ʻāpana like i 3 mau puʻupuʻu i hoʻokaʻawale ʻia). ʻAʻole hoʻi ʻoi aku ka lōʻihi o nā hola ma waena o 12 mau hola, ʻoiai he mea pōʻino o nā neʻe hou. Loaʻa ka hoʻomanawanui maikaʻi o ka gabapentin i nā helu i kēlā me kēia lā a hiki i 4800 mg.

Me nā mea hoʻohiwahiwa i nā keiki 3-12 mau makahiki, ua kauoha ʻia ʻo Katana i kahi kinapo o kēlā me kēia lā he 10-15 mg / kg i 3 mau puʻupuʻu i māhele ʻia. Ma kahi e pili ana i 3 mau lā, e hoʻonui mālie ka ʻaha a hiki i ka hiki loa o ka hana. I nā keiki mai 5 mau makahiki he maʻamau ka 25-35 mg / kg / lā, i nā keiki he 3-5 makahiki - 40 mg / kg / lā (i nāosa he 3 i nā ʻāpana like). Me ka hoʻohana ʻana i ka lōʻihi, ua hoʻomaopopo ʻia ka ʻoluʻolu o ka gabapentin i nā lā i kēlā me kēia lā a hiki i 50 mg / kg. I mea e pale ai i ka hana hou ʻana o nā Seizure, ʻaʻole iʻoi aku ka lōʻihi o waena ma waena o nā pakanō he 12 mau hola.

ʻAʻohe pono e kāohi i ka paʻakikī o ka lāʻau i ka wā e mālama ai. Hiki ke hoʻohana ʻia ʻo Katena me ka hoʻohui me nā anticonvulsants, me ka ʻole o ka hoʻololi ʻana i ka ʻike o nā lāʻau lapaʻau i ka serum.

No ka poʻe maʻi me ka pilikia ʻole, ua hoʻoholo ʻia ka nui o ka lā o Katena e pili ana i ka clearance hana (CC, ml / min):

• oi aku ma 80 - 900-3600 mg,
• 50–79 - 600–1800 mg,
• 30–49 - 300–900 mg,
• 15–29 - 150 * –600 mg,
• emi ma mua o 15 - 150 * –300 mg.

* Kūkala ʻo Katena 300 mg i kēlā me kēia lā.

ʻO nā mea maʻi ʻaʻole i hoʻohana mua i ka gabapentin a ma luna o hemodialysis e kuhikuhi iā Katena i kahi kao saturating o 300-400 mg, a laila hoʻohana ʻia 200-300 mg i kēlā me kēia hola 4 o ka hālāwai hemodialysis.

ʻŌpū a me ka lactation

ʻAʻole paʻa i ka palekana o ka gabapentin i ka wā hapai, no laila ke kuhikuhi ʻia nei ʻo Catena inā he ʻoi mau loa nā mea e manaʻo ʻia o ka hopena e hiki mai ana.

E komo ʻo Gabapentin i loko o ka waiū waiu; no laila, e hoʻopiʻi ʻia ka ʻai inā makemake ʻia ka mālama ʻana i ka wā lactation.

Hoʻohana i ke wā kamaliʻi

Katen contraindicated i ka hoʻohana ʻana:

• a hiki i 18 makahiki o - me ka ʻeha neuropathic,
• a hiki i 12 mau makahiki - e like me ka hoʻokalakupua o nā manawa kahakaha ma ka epilepsy,
• a hiki i 3 mau makahiki - e lilo i mea hana hou i ka hui hoʻohui o nā manawa kūwaho i ka ʻōpū ma ka epilepsy.

ʻO nā palena o ka makahiki ma muli o ka nele o nā ʻike i ka hopena a me ka palekana o kā ke hoʻohana ʻana o Katena e like me nā hōʻailona ma kekahi makahiki.

Hoike e pili ana i Katen

Wahi a nā loiloi, aia ʻo Katena he antiepileptic maikaʻi. Hoʻokomo ʻia nā pōʻino ʻole i ke kumukūʻai kiʻekiʻe i hoʻohālikelike ʻia me nā mākaukau e pili ana i ka carbamazepine, akā naʻe, ʻaʻole like me ia, ʻo ka gabapentin ka liʻiliʻi o nā contraindications a, ma muli o nā loiloi, e hoʻopiʻi i nā hopena liʻiliʻi mai ka ʻōnaehana.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

ʻO ka lāʻau Katen i loko o ke ʻano he papa capsule like-melemele i melemele a ʻili pū ka puiwā. ʻO nā ʻāpana o ka lāʻau lapaʻau: