Lisinoton® (Lisinoton®)

Ka puka helu - nā papa (10 pcs. I loko o kahi pā blister, 3 blisters i loko o kahi kāleka kāleka, 14 mau pcs. I loko o kahi pā blister, 2 mau kihila i loko o ka pā kāleka, he pākēkē ʻia kēlā me kēia kīpē no ka hoʻohana ʻana iā Lysinotone):

• iniha o 5 mg: ka pōpō, pāwili, keʻokeʻo, me ka loaʻa ʻana o nā ʻaoʻao ʻelua,
• dosage o 10 mg: ka pōpō, biconvex, kukui kukui i loko o kala (a ʻo ke kala paha nā kala), me ke ʻano o ka pilikia
• dosage o 20 mg: ka pōʻai, biconvex, ʻulaʻula (a me ka marbling), me ka hopena o ka pilikia.

Helu 1 papa:

• mea kūlohelohe: lisinopril (ma ke ʻano o kahi dihydrate) - 5, 10 a 20 mg,
• Nā mea kōkua: the sodium croscarmellose, calcium hydrogen phosphate dihydrate, magnesium stearate, mannitol, pregelatinized mais starch. ʻO nā papa 10 mg pū kekahi pū me ka pulu pua ʻulaʻula PB-24823, 20 mau papa he 20 i ka papa pulu ʻulaʻula PB-24824.

Lapaʻau lāʻau

ʻO ka mea ikaika o ka lisinotone - lisinopril, he mea paʻa o ka ACE. Hoʻākāka ka hana o kona mana i ke kino ma o ka hiki ke hoʻemi i ka hoʻokumu ʻana o ka angiotensin II angiotensin II, kahi e alakaʻi ai i ka hoʻokuʻu mau i ka hoʻokuʻu ʻana o aldosterone. ʻO kekahi mau hopena o ka lāʻau lapaʻau ma muli o kona hopena i ka ʻōnaehana renin-angiotensin.

Hoʻololi ʻo Lisinopril i ka hōʻemi o ka bradykinin, hoʻonui i ka hōʻailona o ka prostaglandins. E hoʻonui i nā arela i ka ʻoi aku ka nui ma mua o nā veins. Hoʻēmi i ke koko (BP), ka huakaʻi pale kulu peripheral (OPSS), ka pume i ke pulillary pulillary, preload. Hoʻonui i nā minuke koko a me ke kāhea ʻia myocardial i ke koʻikoʻi i loko o nā mea maʻi me ka pūpū puʻuwai naʻau.

Me ka hoʻomehana lōʻihi, hoʻomaikaʻi ka lisinopril i ka hāʻawi ʻana i ke koko i ka myocardium ischemic, e hōʻemi ana i ka hypertrophy o myocardium a i nā paia o nā hāmeʻa o ke ʻano pale.

Hoʻonui ʻo Lysinotone i ka manaʻolana i ke ola ma nā mea maʻi me ka puʻuwai puʻuwai, a me ke kala ʻana hoʻi i ka holomua o ka hōʻolo ʻana o ka ventricular hema i loko o nā mea maʻi ma hope o ka myocardial infarction i ka loaʻa ʻole o nā hōʻike pilikino o ka hiki ʻole o ka naʻau.

Ma hope o hoʻokahi hopena o Lysinotone, ulu ka hopena hypotensive ma hope o ka hola 1, hiki aku i ka lōʻihi ma waena o 6 mau hola, mau no 24 mau hola. ʻO ke lōʻihi o ka hopena e hilinaʻi hoʻi i ka hopena o ka lāʻau. Me ka hypertension arterial, hōʻike ʻia ka hopena iā ia iho i nā lā mua ma hope o ka hoʻomaka ʻana o ka lapaʻau, hoʻomohala kahi hopena paʻa ma hope o 1-2 mau mahina.

Ma ka hihia o ka haʻalele hou ʻana o Lysinotone, ʻaʻole i ʻike ʻia kahi hoʻonui nui o ke koko.

Hoʻopau ka Lisinopril i ka albuminuria. Me ka hyperglycemia, kōkua ia i ka hoʻohālikelike i nā hana o ka endothelium glomerular i hōʻino ʻia. ʻAʻohe mea paʻa i ka nui o ka glucose i loko o ke koko o nā poʻe maʻi me ka maʻi mellitus, ma muli o ia kumu, ʻaʻole ia he kumu o ka hoʻonui ʻana i nā moʻolelo o ka hypoglycemia.

Lapaʻau lāʻau

Hoʻokahi i loko o ka hana gastrointestinal, hoʻopili ʻia ka lisinopril ma kahi o 30%. ʻAʻole make ka ʻai i ke kiʻekiʻe o ka inu ʻana o ka lysinotone.

ʻO Bioavailability ʻo 29%. Loaʻa ka ʻike kiʻekiʻe ma loko o nā hola 7 a i nā helu o 90 ng / ml.

ʻAʻole paʻa ʻo Lisinopril i ka protein plasma. E hoʻokaʻawale i ke koko-lolo a me ka pale i ka paleʻana i nā haʻahaʻa haʻahaʻa.

ʻAʻole i biotransformed. Hoʻokuʻu ʻia ia i nā loli a ke keiki. ʻO ka hoʻopau hapa hapalua-ola he 12 mau hola.

Nā hōʻailona no ka hoʻohana ʻana

• ka maʻi o ka maʻi myocardial infarction a me nā ʻōhua hemodynamic paʻa i ka wā mua - i mea e mālama ai i nā ʻāpana hemodynamic a pale i ka hoʻomohala ʻana o ka maʻi ventricular hema a me ka puʻuwai ʻole,
• monotherapy a hui pū paha therapy o ka arterial hypertension,
• ka hui pū ʻana o ka pilikia puʻuwai paʻakikī (i hui pū me ka diuretics a me / a me ka hoʻomākaukau ʻana i ka digitalis hoʻomākaukau).

Nā Hoʻohui

• edema kahe ma Quincke,
• ka mōʻaukala o ke angioedema (me ka manaʻo o ke kumu),
• makahiki i 18 makahiki
• hapai a lactation
• hypersensitivity i kekahi o ka lāʻau o ka lāʻau lapaʻau a i ʻole kekahi mea ʻē aʻe ACE inhibitors.

Hoʻohana ʻia nā papa lysinotone me ka akahele:

• pilikia hōʻeha, ʻoi aku ka hopena o ka renal, stenosis o hoʻokahi ʻōpū o ke keiki pākahi me ka azotemia holomua a i ʻole ka lua o ka maʻi o ka renater stalosis, nā kūlana ma hope o ka hoʻololi ʻana i ka huehue,
• azotemia, hyperkalemia,
• nā kūlana hypovolemic (me ke ʻano o ka maʻi a i ʻole ka luaʻi).
• pale ʻana i ka momona hematopoiesis,
• maʻi ʻeha coronary, hypotension arterial, hypertrophic obstruktive cardiomyopathy, stenosis o a oricice aortic, pono o ka coronary,
• hyperaldosteron's,
• maʻi maʻi ʻōnaehana o ka autoimmune o ka kiko konohui (me ka scleroderma a me ka systemus lupus erythematosus),
• maʻi maʻi cerebrovascular (me ka haʻahaʻa cerebrovascular)
• hiʻona kiʻekiʻe
• ka hoʻomau ʻana i ka papaʻai me ka hoʻōla ʻole o ka paʻakai.

Lisinoton, nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana: ke ʻano a me ka helu ʻana

Hōʻike ʻia nā papa Lysinotone no ka hoʻoponopono waha.

Me ka hypertension arterial, me ka lāʻau lapaʻau hoʻokahi, ua kuhikuhi ʻia ʻo Lysinoton i ka 5 mg hoʻokahi i ka lā. Inā lawa ka hopena hypotensive, hoʻonui ʻia ke ʻano e ka 5 mg i kēlā me kēia 2-3 mau lā a hiki i ka hopena i makemake ʻia, akā ʻaʻole iʻoi aʻe ma mua o 40 mg i kēlā me kēia lā. ʻO ka mālama ʻana i kēlā me kēia lā maʻamau ka 20 mg. Hoʻohui pinepine ka hopena piha ma hope o nā hebedoma 2-4 o ka lapaʻau, pono ia e mālama i ka wā o ka hopena titration. Inā paha ma hope o ka lawe ʻana i ka nui o kēlā me kēia lā, ʻaʻole i emi ka nui o ke koko, e kuhikuhi i ka lāʻau hoʻohui.

ʻO nā mea maʻi i loaʻa i ka diuretics e pono e hoʻopau loa i nā lā 2-3 ma mua o ka hoʻomaka ʻana e lawe iā Lysinotone. Inā ʻaʻole hiki ʻole kēia, pono ka laʻa o ka lā mua o lisinopril me ka 5 mg. I loko o kahi mau hola (ma kahi o 6 mau hola) ma hope o ka lawe ʻana i ka ʻaina mua, pono mālama ʻia ka mea maʻi e ke kauka e nānā i ke kaʻina o ke kahe ʻana o ke koko (e pale i kahi hāʻule i haʻi ʻia.)

Ma kahi o ka renovascular hypertension a me nā kūlana ʻē aʻe me ka nui o ka hana o ka ʻōnaehana renin-angiotensin-aldosterone (RAAS), pono pū ʻia hoʻi e hoʻomaka i ka lawe ʻana iā Lisinoton ma lalo o ka mākaʻi kokoke o kahi kauka (ke kahe o ke koko, ke ʻano hana a me ka hoʻomau i kā calum potassium) ma kahi haʻahaʻa o ka uku ma mua - 2.5-5 mg i ka lā. Hoʻoholo ʻia ka mālama mālama ʻia e nā hopena o nā dinamics o ka hoʻohaʻahaʻa i ke koko.

I ka poʻe maʻi me ka pilikia ʻole, ua hoʻoholo ʻia ka hopena mua o Lysinotone e pili ana i ka clearance creatinine (CC). Hoʻomoe ʻia ka mālama mālama ʻia e like me ka maʻa o ka hopena ma lalo o ka mālama ʻana i ka hana o ka renal a me ka nānā ʻana o ka serum potassium.

Noi aku ka hoʻomaka ʻana i nā inikua no nā maʻi me ka loaʻa ʻole o ka renal:

• KK 30-70 ml / min - 5-10 mg,
• KK 10-30 ml / min - 2.5-5 mg,
• QC

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

i loko o nā pā heʻe he 10 a he 14 mau pcs., i loko o kahi ʻeke pepa 3 a i ʻole 2 mau ʻāpana, kēlā me kēia.

i loko o nā pā heʻe he 10 a he 14 mau pcs., i loko o kahi ʻeke pepa 3 a i ʻole 2 mau ʻāpana, kēlā me kēia.

i loko o nā pā heʻe he 10 a he 14 mau pcs., i loko o kahi ʻeke pepa 3 a i ʻole 2 mau ʻāpana, kēlā me kēia.

ʻO ka wehewehe ʻana i ke ʻano dosis

Nā papa ʻaina 5 mg: puni, nā papa biconvex, me kahi notch, keʻokeʻo.

Nā papa ʻaina 10 mg: poepoe, papa hāmeʻa biconvex, me kahi aniani, ʻulaʻula mālamalama.

20 mg papa: puni, nā papa biconvex, me kahi notch, pink, marbling.

Nā hōʻailona o ka lāʻau Lysinoton ®

Hypertension arterial (ma monotherapy a i hui pū ʻia me nā mea'ē aʻe antihypertensive), hōʻeha kūloko o ka naʻau (ma ke ʻano he hui hoʻohui no nā mea maʻi e lawe ana i ka digitalis a / a i ʻole diuretics), ka mālama mua i ka maʻi myocardial infarction (ma nā hola 24 mua me ka hemodynamics mau no ka. ke mālama nei i kēia mau kuhikuhi a pale aku i ka hemahema o ka ventricular hema a me ka pohō o ka naʻau).

ʻŌpū a me ka lactation

Hoʻopili ʻia ka hoʻohana ʻana o ka lisinopril i ka wā hapai. Ke paʻa nei ka hapai, pono e hoʻokuʻu ʻia ka lāʻau i ka hiki. ʻO ka ʻae ʻana o nā mea paʻa o ka ACE i loko o ka wā ʻo II a me III kahi o ka hapala i loaʻa ka hopena maikaʻi loa i ka ʻōpio (kahi i hoʻohaʻaha ʻia ka nui o ke koko, ke aloha ʻole, hyperkalemia, ʻopa hypoplasia, hiki i ka make intrauterine). ʻAʻohe ʻikepili i nā hopena maikaʻi ʻole o ka lāʻau lapaʻau ma ka fetus inā hoʻohana ʻia i ka wā o ka trimester mua. No nā pēpē a me nā pēpē e hana nei i ka ʻike intrauterine i nā mea hōʻiliʻili o ka ACE, e hāmama ʻia e mālama kiaʻi i ka manawa kūpono e ʻike i kahi hōʻemi o ke koko, oliguria, hyperkalemia. Hoʻopau ʻo Lisinopril i ka pleka. ʻAʻohe ʻikepili i ka pā ʻana o ka lisinopril i ka waiū umauma. No ka wā o ka mālamaʻana me ka lāʻau lapaʻau, pono ia e hoʻopau i nā hōʻuluʻulu.

Nā hopena hopena

ʻO ka hopena pinepine ka hopena i ka dizziness, headache (i ka 5-6% o nā mea maʻi) nāwaliwali, ke nānā ʻana, ka maʻi ʻana, ka wai maloʻo (3%), ka lua, ka luaʻi, ka hypthension orthostatic, ʻeha ʻeha, ʻeha ʻeha (1-3%).

Nā hopena ʻē aʻe (ke alapine o ke koko, orthostatic hypotension, impalired renal function.

Mai ka ʻaoʻao o ka pīkī laha waena: luhi, luhi, lohi i ka piliki o nā manamana lima a me nā lehelehe.

Mai ka ʻōnaehana hemopoietic: hiki i ka leukopenia, neutropenia, agranulocytosis, thrombocytopenia, me ka lōʻihi o ka hoʻōla ʻana - ʻo ka hoʻokaʻawale ʻana o ka hemoglobin me hematocrit, erythrocytopenia.

Nā hōʻailona kuhikuhi: hyperkalemia, azotemia, hyperuricemia, hyperbilirubinemia, hoʻonui i ka hana o nā "enzyme" enzymes, ʻoiai inā he moʻolelo o nā maʻi o ka pēpē, ka maʻi mellitus a me nā hypovension renovascular.

Loaʻa pinepine ʻia nā hopena ʻaoʻao:

Mai ka pūnaehana cardiovascular: palpitations, tachycardia, myocardial infarction, cerebrovascular stroke ma ka poʻe maʻi me ka nui o ka ʻeha o ka maʻi, ma muli o kahi hōʻemi o ke kahe koko.

Mai ka hāliʻi ʻana o ka huina: waha maloʻo, anorexia, dyspepsia, hoʻololi i ka ʻōpū, ʻeha hōʻeha, ka ʻōpū o ka ʻōpū, ka pancreatitis, hepatocellular a i ʻole cholestatic jaundice, hepatitis.

Ma ka ʻāpana o ka ʻili. ka ʻōpūpū, ka ʻūlū, ka ili o ka ʻili, alopecia.

Mai ka urinary system: impalired renal function, oliguria, anuria, acute renal failed, uremia, proteinuria.

Mai ka ʻaoʻao o ka pīkī laha waena: asenaiic syndrome, ʻili lūlū, hūnā.

Nā ʻili: myalgia, ʻala, paʻa i ke kūkulu ʻana i ka wā hānau, ua emi iho ka ʻōpū.

Hoʻohui

E koi ʻia ka nui o ka wili i ka wā e hoʻohana ai i ka lāʻau lapaʻau me ka diuretics potassium-sparing (spironolactone, triamteren, amiloride), pāhare, ka paʻakai a ka paʻakai ka nui o ka paʻakai (ʻo ka pilikia o ka hoʻoulu ʻana i ka hyperkalemia e hoʻonui, ʻo ia hoʻi me ka hana renal impaired, no laila, hiki iā lākou ke kuhikuhi pū me ka manaʻo wale nō o ka hoʻoholo a ke kauka hoʻokahi me ka maʻamau. ka nānā ʻana i ka pae o ka serum potassium a me ka hana o ke keiki).

Hiki ke hoʻohana pū ʻia ka mālama ʻana:

- me ka diuretics: me ka ka hoʻomohala hou o ka diuretic i ka mea maʻi e lawe ana iā Lisinoton, me he mea la, he hopena antihypertensive hopena e kū mai - kahi hopena o kahi hōʻemi i hoʻemi ʻia i ke koko. Hoʻololi ʻo Lisinopril i ka maʻa o ka pāhana mai ke kino i ka wā e mālama ai me ka diuretics,

- me nā mea hana antihypertensive (hoʻohui i ke ʻano),

- me NSAIDs (indomethacin, etc.), estrogens, a me ka adrenostimulants - he ʻemi i ka hopena antihypertensive o lisinopril,

- me ka lithium (e hoʻoheheʻe ʻia ka lithium, no laila, e nānā mau pono ʻia ka serum lithium).

- me nā antacids a me colestyramine - hōʻemi i ka komoʻana i ka pā Kahelehele.

Hoʻonui ka lāʻauʻona i ka hopena o ka lāʻau lapaʻau.

ʻLoe a me ke kākele

I loko. Me ka hypertension arterial, ʻaʻole i loaʻa nā mea maʻi i nā lāʻau antihypertensive e like me 5 mg hoʻokahi i ka lā. Ke hala ʻole o ka hopena, hoʻonui ʻia ke kahe i kēlā me kēia 2-3 mau lā ma ka 5 mg i ka awelika therapeutic o 20-40 mg / lā (e hoʻonui ana i ka momona ma luna o 40 mg / lā maʻamau ʻaʻole alakaʻi i ka emi o ke kahe koko). ʻO ka dosis lapaʻau maʻamau maʻamau i kēlā me kēia lā he 20 mg. ʻO ka pae ʻauʻau nui loa ʻo kēlā me kēia lā he 40 mg.

Hoʻohālikelike ka hopena piha ma hope o 2 mau hebedoma mai ka hoʻomaka ʻana o ka mālama ʻana, pono e lawe ʻia i ka wā e hoʻonui ana i ka kūpaʻa. Me ka hopena ʻole o ka lāʻau lapaʻau, hiki ke hoʻohui i ka lāʻau lapaʻau me nā lāʻau lapaʻau antihypertensive ʻē aʻe.

Inā loaʻa i ka mea maʻi ka hoʻomaʻamaila mua me ka diuretics, a laila pono e hooki ʻia ka hoʻohana ʻana i kēlā mau lāʻau i ka lā 2-3 ma mua o ka hoʻomaka ʻana o ka hoʻohana ʻana o ka lisinotone. Inā ʻaʻole kūpono kēia, a laila ʻaʻole pono ka hopena mua o Lysinotone ma mua o 5 mg / lā. Ma kēia hihia, ma hope o ka lawe ʻana i ka maʻi mua, ua mālama ʻia ka nānā ʻana i nā mea lapaʻau no kekahi mau hola (ʻo ka hopena ʻoi loa ka hopena ma hope o ka 6 mau hola), no ka mea hiki paha ke emi o ke kahe koko.

Me ka Renovascular Hypertension a i ʻole nā ​​kūlana ʻē aʻe me ka nui o ka hana o ka ʻōnaehana renin-angiotensin-aldosterone, ua ʻōlelo ʻia nō hoʻi e kuhikuhi i kahi helu haʻahaʻa haʻahaʻa o 2.5-5 mg i kēlā me kēia lā, ma lalo o ka mālama olakino hoʻolōʻihi (ka hoʻomalu i ke koko, hana hana, lawelawe kikowaena serum). ʻO ka dosis mālama, e hoʻomau i ka mālama olakino koʻikoʻi, pono e hoʻoholo i ka dinamics o ke koko.

Me ka pani ʻole ʻana ma muli o ka mea i hoʻopili ʻia ai ka lisinopril ma o nā ʻōpū, pono ke hoʻoholo ʻia ka ʻōlelo mua ma muli o ka ʻae ʻana o ka creatinine, a laila, e like me ke ʻano o ka hopena, e pono ke kūkulu ʻia kahi mālama mālama ma lalo o nā mākaʻikaʻi pinepine o ka hana renal, potassium, sodium i loko o ka serum o ke koko (me nā poʻe maʻi. mālama ʻia me ka hemodialysis).

Me ka uluʻana o ka haole hypertension hōʻike ʻia kahi mālama mālama lōʻihi o 10-15 mg / lā.

I loko o nā pūpū puʻuwai hema - e hoʻomaka me ka 2.5 mg 1 mau manawa i kēlā me kēia lā, ukali ʻia hoʻi e ka hoʻonui i ka palena o 2.5 mg ma hope o 3-5 lā i ka maʻamau, e kākoʻo ana i ka helu o kēlā me kēia lā o 5-20 mg. ʻAʻole pono ka make i ka 20 mg / lā.

I ka poʻe kahiko, ʻike pinepine ʻia ka hopena a me ka lōʻihi o ka hypotensive, i pili ʻia me ka hoʻohaʻahaʻa ʻana i ka helu lisinopril excretion (ua ʻōlelo ʻia e hoʻomaka i ka mālama ʻana me ka 2.5 mg / lā).

Acoc myocardial infarction (ma ke ʻano o ka hui pū ʻana). I ka lā mua - 5 mg oralally, a laila 5 mg i kēlā me kēia lā, 10 mg ma hope o 2 mau lā a laila 10 mg hoʻokahi i ka lā. I nā maʻi me ka maʻi myocardial infarction, pono ke hoʻohana ʻia ka lāʻau lapaʻau no ka liʻiliʻi o 6 mau pule.

I ka hoʻomaka ʻana o ka hoʻōla a i ka wā mau lā 3 a pau ma hope o ka maʻi myocardial infarction i loko o nā mea maʻi me ke koko haʻahaʻa haʻahaʻa (120 mm Hg a i ʻole), pono ke kuhikuhi i kahi haʻahaʻa haʻahaʻa o 2.5 mg. Ma kahi o ka emi ʻana o ke kahe o ke koko (SBP ma lalo a i ʻole like me 100 mm Hg), kahi lāʻau i kēlā me kēia lā o 5 mg hiki, inā pono, e hoʻemi iki ʻia i ke anuanu he 2.5 mg.Ma ka hihia o ka lohi i hoʻokahe nui i ka nui o ke koko (SBP ma lalo o 90 mm Hg. Art. Oi aku ma mua o ka hola 1), e hoʻopau i ka hana me Lisinoton.

Ke keu

Nā Hoʻomaka (i ka wā e lawe ai i ka pākahi o 50 mg): kahi hōʻailona i hōʻemi ʻia i ke koko, moka maloʻo, ka ʻalelona ʻana, mālama i ka urinary, constipation, hopohopo, hoʻonui i ka huhū.

Lāʻau: Hāʻawi ʻOi aku ka maʻi maʻi, ka mālama ʻana i ka wai o ka wai, ka mālama o ke koko, ke kaulike i ka wai-electrolyte a me ka hoʻohaʻahaʻa i ka hopena o ka hopena. Hiki ke hoʻopau i ka Lysinotone e ka hemodialysis.

Nā ʻōlelo kikoʻī

Nā hōʻailona hāpū. ʻO ka pinepine, ʻo ka hōʻemi o ka neʻe o ke koko e loaʻa ana me ka hoʻohaʻahaʻa ʻana i ka nui o ka wai i hoʻihoʻi ʻia e ka diuretic therapy, ʻo ke emi ʻana o ka nui o ka paʻakai i ka meaʻai, ka dialysis, ʻōpū, a i ʻole ka luaʻi. I ka poʻe maʻi me ka puʻuwai naʻau paʻakikī me ka hoʻolaʻa ʻole ʻana o ka renal a i ʻole ʻole me ia, kahi hiki ke hōʻemi ʻia kahi hōʻailona nui i ke koko. ʻOi aku ka loaʻa pinepine o nā maʻi i nā maʻi me ka puʻuwai koʻikoʻi o ka puʻuwai, ma muli o ka hoʻohana nui ʻana o nā dosis nui o ka diuretics, hyponatremia, a me ka hana ʻole. I kēlā mau mea maʻi, pono e hoʻomaka ʻia ka mālama ʻana me Lisinotone ma lalo o ka mākaʻikaʻi koʻikoʻi o kahi kauka (me ka makaʻala, koho i kahi ʻano o ka lāʻau a me ka diuretics). Pono e mālama pono nā lula like i ka lawe ʻana i nā mea maʻi me ka maʻi puʻukū coronary me ka cerebrovascular insufficiency, ma kahi hōʻemi nui i ke koko e hiki ke alakaʻi i ka myocardial infarction a i ʻole stroke. ʻO kahi pane transit hypotensive ʻaʻole ia he contraindication no ka lawe ʻana i ka hopena hou o ka lāʻau. Ke hoʻohana nei iā Lysinotone i kekahi mau mea maʻi me ka puʻuwai puʻuwai puʻuwai, akā me ka hoʻohaʻahaʻa maʻamau a haʻahaʻa paha, hiki ke emi mai kahi lohi o ke koko, ka mea maʻamau ʻaʻole ia he kumu no ka hoʻokuʻu ʻana i ka mālama ʻana. Ma mua o ka hoʻomaka ʻana i ka mālama ʻana me Lysinotone, inā hiki, hoʻokaʻawale i ka sodium a me / a i ʻole no ka pau ʻana o ka wai o ka hoʻoheheʻe, e kiaʻi pono i ka hopena o ka hopena mua o Lysinotone ma ka mea maʻi. Ma ka hihia o ka stenosis o ka aralula (ʻoi aku ka hihia o ka stenosis bilateral, a i ʻole ka hele ʻana o ka stenosis o ke aʻa o hoʻokahi ʻōiwi), ʻo ia hoʻi me ka pau ʻole o ke kaila helehelena ma muli o ka nele o ka sodium a / a ihaila, ʻo ka hoʻohana ʻana o Lysinotone hiki ke alakaʻi i ka hana renal, He ʻokoʻa ʻole ma hope o ka hoʻokuʻu ʻana o ka lāʻau lapaʻau.

Ma kaʻeha pūpale myocardial. Ke hōʻike ʻia nei ke hoʻohana ʻana o ka hana maʻamau (thrombolytics, acetylsalicylic acid, beta-blockers). Hiki ke hoʻohana 'ia Lysinotone i ka pilina me ka limahana iv a me ka hoʻohana ʻana o nā polokalamu therapeutic transdermal system o nitroglycerin.

Hoʻolālā / inesthesia ākea. Me nā wawaʻi o ka nui o ka maʻi, a me ka hoʻohana ʻia o nā lāʻau ʻē aʻe e hōʻemi ai i ka hoʻokahe o ke koko, lisinopril, ke kāohi nei i ka hoʻokumu ʻana o ka angiotensin II, hiki ke kahi i ka hōʻemi ʻia ʻole o ka pehu o ke koko.

I nā maʻi maʻi maʻi like kēia ka hopena i ka kiʻekiʻe kiʻekiʻe o ka lāʻau lapaʻau i loko o ke koko, no laila, pono ka mālama kūikawā i ka wā e hoʻoholo ai i ke ʻano, ʻoiai i ʻole nā ​​ʻokoʻa ʻole i ka hopena antihypertensive o Lysinotone ma waena o ka poʻe elemakule a me nā ʻōpio. Ma muli o ka hiki ʻana o ka mehe e pili ana i ka agranulocytosis i ʻole e hoʻoholo ʻia, koi ʻia ka nānā ʻana i ka manawa koko. Ke hoʻohana nei i ka lāʻau lapaʻau ma lalo o nā kūlana dialysis me kahi membrane polyacrylonitrile, hiki mai ke ʻano he anaphylactic, no laila, ʻōmole ʻia kēlā me kēia ʻano like ʻole o ka membrane no ka dialysis, a i ʻole ke koho ʻana i nā mea hana antihypertensive.

ʻAʻohe ʻikepili e pili ana i ka hopena o ka lisinopril, i hoʻopili ʻia ma nā hopena therapeutic, i ka hiki ke ke kaʻa i nā kaʻa a me nā hana hoʻokele, akā pono e noʻonoʻo ʻia he hiki paha ka dizziness, no laila e pono e mālama ʻia.

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana a me ka pōpoki

Ua puni nā papa, biconvex, ʻulaʻula kukui i ke kala, me kahi kakana, me ka lōʻihi o 7 mm.

Nā mea hoʻoweliweli: mannitol, kallea phosphate disubstituted dihydrate, pregelatinized kāka palaoa, croscarmellose sodium, magnesium stearate, lepo (E172).

10 kamepiula - nā kāmele (2) - nā kīʻaha o ke kāleka.
14 ʻōpō. - nā kāmele (2) - nā kīʻaha o ke kāleka.

Ka hana lāʻau lapaʻau

ʻO kahi paʻa ACE kahi polypeptidase kahi e hoʻopili ai ka huli ʻana o ka angiotensin I ka angiotensin II. ʻO Angiotensin II ke kumu o ka vasoconstriction a hoʻoulu i ka mea huna o ka aldosterone.

Ke alakaʻi nei iā ACE e alakaʻi i ka nāwaliwali o ka hana vasoconstrictor a me kahi hoʻohaʻahaʻa i ka huna ʻana o ka ald testosterone. I ka hopena, hiki i ka liʻiliʻi liʻiliʻi i ke pae o ka serum potassium. I ka poʻe maʻi me ka hypertension arterial a me ka hana maʻamau, ka loaʻa ʻana wale nō lisinopril no ʻoi aku 24 mau hebedoma, ʻo ka nui o ka hoʻonui ʻana ma ka potassium serum ma kahi o 0.1 meq / L. Eia naʻe, like me 15% o nā mea maʻi e hōʻike ana i ka hoʻonui nui aʻe ma mua o ke 0.5 meq / l a ma kahi o 6% e hōʻike ana i ka emi ʻana o nā mea ma mua o 0.5 meq / l. Ma nā haʻawina like like ʻole, nā mea maʻi e loaʻa lisinopril a me hydrochlorothiazide no 24 mau makahiki he hōʻike i ka hoʻemi o ka nui o ka serum potassium level o 0.1 meq / l, ma kahi o 4% o lākou e hōʻike ana i ka hoʻonui o ka maʻa o ka 0.5 meq / l, a ma kahi o 1.2% ka emi ana o oi aku me 0.5 meq / l.

Hoʻohālikelike ʻo ACE me ka kininase, he enzyme e hoʻopau ai i ka bradykinin. ʻO ka hana o nā kiʻekiʻe o ka bradykinin (me nā hua vasodilating i hoʻolaha ʻia) i ka wā o ka mālama ʻana me ka lisinopril ʻaʻole maopopo loa ia a koi aku i nā haʻawina hou. ʻOiai ka hana o ka hoʻohaʻahaʻa i ke koko i ka wā o ka mālama ʻana me ka lisinopril ma ke kumu nui o ka pale ʻana o ka renin-angiotensin-ald testosterone, ua loaʻa ka lisinopril i ka hopena hypotensive i loko o nā poʻe maʻi me ka maʻi hypertension me ka haʻahaʻa o renin. ʻOiai ka lisinopril he hopena antihypertensive i nā mea maʻi o nā lāhui āpau, nā mea maʻi me ka hypertension arterial - nā māka o ka lāhui ʻeleʻele (ʻike ʻia kēia heluna ma muli o ka renin) e hōʻike ana i kahi pane haʻahaʻa haʻahaʻa o ka monotherapy ma mua o nā poʻe maʻi e pili ana i nā lāhui ʻē aʻe. ʻO ka hoʻohana like ʻana o ka lisinopril a me ka hydrochlorothiazide e hōʻemi hou i ke kahe o ke koko i nā mea maʻi - nā ʻelele o nā ʻeleʻele a me nā lāhui ʻē aʻe, ma muli o nā ʻano ʻokoʻa i ka hopena antihypertensive ma muli o ke ʻano lahui.

ʻO ka hoʻohana ʻana o ka lisinopril no ka hypertension arterial e hōʻemi i kahi kahe o ke koko i aneane like i ka pae nui a kū i ka kūlana supine a kū, me ka ʻole o ka hoʻopiʻi ʻana i tachycardia uku. ʻAʻole ʻike ʻia nā hopena Orthostatic, ʻoiai inā hiki ke kū ʻia ana kā lākou hanana, ʻoiai me ka dehydration a i ʻole ke kaupalena electrolyte. Ke hui pū me ka diuret thiazide, ʻoi aku ka maikaʻi o ka hopena antihypertensive.

I ka hapa nui o nā mea maʻi, ka hoʻomaka ʻana o ka hana antihypertensive e mālama i ka hola 1 ma hope o ka lawelawe waha ʻana o ka lāʻau i loko o hoʻokahi pākahi, ʻoi ka hopena kiʻekiʻe ma hope o nā hola he 7. Ua hoʻomau ka hopena antihypertensive no nā hola 24 ma hope o ka lawe ʻana i ka lāʻau lapaʻau i loko o kēlā me kēia lā. Wahi a kekahi mau noiʻi, ma ka awelika, ʻoi aku ka mau o ka hopena ma ke ʻano o ka lawe ʻana i ka lāʻau lapaʻau i nā popo o 20 mg a ʻoi aku paha ma mua o ka lawe ʻana i nā dosis liʻiliʻi. Eia nō naʻe, me nā maʻi āpau i aʻo ʻia, ʻoi aku ka hopena antihypertensive ka hopena ma mua o 24 mau hola ma hope o ka 6 mau hola.

I kekahi mau mea maʻi, e hoʻokō pono i ka hōʻemi ʻana i ke kahe o ke koko, pono paha e inu i ka lāʻau lapaʻau maʻamau no nā hebedoma 2-4.

ʻAʻole ka emi o ka hopena antihypertensive lisinopril i ka wā lōʻihi. ʻO ke kaila hoʻoneʻe wikiwiki ʻaʻole alakaʻi i kahi hoʻonui wikiwiki a koʻikoʻi paha i ka neʻe koko (hoʻohālikelike me ke koko i mua o ka lāʻau).

ʻO ka emi o ke neʻe ke koko e hele wikiwiki a hoʻonui i ka wā e lawe i ka lāʻau i ke kiʻekiʻe kiʻekiʻe.

ʻO ka like o ka lisinopril a me nā hoʻopiʻi maikaʻi ʻana i like nō ia i nā mea maʻi ʻōpio a me nā mākua.

Ka hoʻoponopono ʻia ʻana

Me ka hypertension arterial, ka hopena mua o ka lāʻau no ka poʻe maʻi i loaʻa ʻole ma mua nā lāʻau lapaʻau antihypertensive e like me 5 mg 1 manawa / lā i ke kakahiaka. I ka wā e hiki mai ana, ʻoi aku i ka hopena o ke kahe o ke koko, nā kīwaha no ka mālama mālama ʻia he 10-20 mg 1 manawa / lā. Hiki ke hopena e loaʻa ana ka hopena antihypertensive ma hope o nā hebedoma 2-4 mai ka hoʻomaka ʻana o ka lāʻau. ʻO ka hoʻonui ʻana i ka nui o ka mahele o ka 40 mg / lā ʻaʻole e alakaʻi mau i ka hoʻonui i ka hopena. I kēia hihia, ua noi ʻia ka lāʻau hui me ke koho hou o ka diuretic ma kahi haʻahaʻa haʻahaʻa (a laila e loaʻa ai ka hoʻohui o ka hana). ʻAʻole pono nā dosis o ka lā nui ma mua o 80 mg. I nā maʻi i loaʻa i ka diuretics ma mua, pono lākou e kāpae ʻia i nā lā 2-3 ma mua o ka hoʻomaka ʻana o ka hoʻohana o lisinotone. Pono ka dosis hou o kēlā me kēia lā i kēia mau hihia ma mua o 5 mg / lā. Ma hope o ka lawe ʻana i ka pākahi mua, hōʻike ʻia ka mālama ʻana i ka lāʻau a hiki i ka hoʻokō ʻana o ka hoʻopaʻa ʻana i ke koko.

I ka hana ʻole o ka puʻuwai, hoʻohana ʻia ka lāʻau ma ke ʻano o ka lāʻau paʻakikī i ka manawa like me ka diuretics a me / a i ʻole glycosides cardiac. ʻO ka inumua mua o Lysinotone he 2.5 mg / lā i ke kakahiaka, i ka wā e hiki mai ana ka hoʻonui ʻia ʻana o 5-10 mg 1 mau manawa / lā. ʻO ka 20 mg kiʻekiʻe loa i kēlā me kēia lā.

No ka mālamaʻana i ka infarction myocardial waha, e pono ke hoʻohana ʻia ka lisinotone e like me ka hoʻopili i ka hana maʻamau (me ke ʻano pū me ka hoʻohana ʻana i ka nitrates). I ka poʻe maʻi me ka hemodynamics mau, hiki ke mālama ʻia ka mālama ʻana i loko o nā 24 mau hola ma hope o ka hoʻomaka ʻana o nā hōʻailona o ka hōʻeha ʻana o ka puʻuwai. ʻO ka maʻa mua o Lysinotone he 5 mg, a laila 5 mg ma hope o 24 mau hola, 10 mg ma hope o 48 mau hola a laila 10 mg / lā.

No nā mea maʻi me ka hoʻokahe koko systola haʻahaʻa (emi iho ma lalo o 120 mm Hg) i ka hoʻomaka mua o ka mālama ʻana a i ʻole ma ka 3 mau lā 3 ma hope o ka hoʻomaka ʻana o ka hōʻeha ʻana o ka puʻuwai, ʻo ka make ka 2.5 mg. I mua o ka hoʻonui ʻana o ka maʻi arterial (kahe koko systolic ma lalo o 100 mm Hg), pono e mālama ʻia ka nui o ka mālama i kēlā lā i kēia lā he 5 mg a, inā pono, hiki ke hoʻemi ʻia i ka 2.5 mg. Me ka hoʻomau i ka hoʻoneʻe o ka arterial (systolic blood pressure haʻahaʻa ma mua o 90 mm Hg no kaʻoi aku ma mua o hoʻokahi hola), pono e hoʻōla ʻia ka mālama ʻana me ka lisinotone.

ʻO 6 mau lōʻihi ka lōʻihi o ka lapaʻau. ʻO ka helu hoʻomaha haʻahaʻa loaʻo 5 mg / lā. Inā loaʻa nā hōʻailona o ka puʻuwai naʻau, pono e hoʻomau ʻia ka mālama ʻana.

I ka poʻe maʻi me ka hana renal impaired, ua hoʻoholo ʻia ke ʻano ma muli o ka QC.