He aha ka mea likeʻole ma waena o Finlepsin me Finlepsin Retard? Finlepsin retard: nā ʻōlelo no ka hoʻohana ʻana

Federal Center no Neurosurgery

HANEA ʻO KA MANA Hou.

Akā he mea hoʻohana ʻole ʻole ʻia.

Inā ʻoe i kau inoa ma mua, a laila "login" (inoa inoa ma ka ʻaoʻao ʻākau o ka pūnaewele). ʻO kēia kou manawa mua ma ʻaneʻi, e kau inoa.

Inā ʻoe e kāinoa, hiki iā ʻoe ke nānā i nā pane i kāu mau memo i ka wā e hiki mai ana, e hoʻomau i ka kūkākūkā i nā kumuhana hoihoi me nā mea hoʻohana e like me nā mea kūkākūkā. Eia kekahi, hiki i ke hoʻopaʻa inoa ke hoʻokō iā ʻoe i ka leka pilikino me nā mea kūkākūkā a me nā mea hoʻohana o ka pūnaewele.

ʻLoe a me ke kākele

100 mg i ke ahiahi 100 mg i ke ahiahi
ʻO kahi papa mālama hoʻomaha o 200-600 mg i kēlā me kēia lā i ke kakahiaka 400-600 mg i ke ahiahi
200 mg i ke kakahiaka 200-400 mg i ke ahiahi 200-400 mg i ke kakahiaka 400-600 mg i ke ahiahi

ʻAʻole pono e hoʻonui ʻia nā pae i hōʻike ʻia i loko o ka papaʻaina.
Ka hopena o ka hoʻohaʻahaʻa ʻana i ka ʻona ma kahi wahi hoʻomaha.
ʻO ka awelika nui o kēlā me kēia lā e pili ana i 600 mg o ka carbamazepine (200 mg i ke kakahiaka a me 400 mg i ke ahiahi).
Oh
I nā pilikia koʻikoʻi, hiki i ka lā mua, hiki ke hoʻonui ʻia i ka nui i 1200 mg o ka carbamazepine i kēlā me kēia lā, ka mea i hoʻokaʻawale ʻia i 2 mau pūmole. ʻAʻole pono ke hui pū me ka retard Finlepsin me nā lāʻau lapaʻau sedative-hypnotic. Inā pono, hiki ke hoʻohui pū ʻia ʻo retlepsin retard me nā mea ʻē aʻe i hoʻohana ʻia e mālama ai i ka hōʻemi o ka waiʻona. I ka wā o ka mālamaʻana, pono ia e kiaʻi pinepine i nā kiko o ka carbamazepine i loko o ke koko koko. I ka pilina me ka hoʻomohala ʻana i nā hopena ʻaoʻao mai ka Central and autonomic nervous system, nānā pono nā mea maʻi i kahi ʻōna o ke haukapila.
Neuralgia Trigeminal, idiopathic neuropathy o ka hoʻopili glossopharyngeal.
ʻO ka dosis mua he 200-400 mg o ka carbamazepine i kēlā me kēia lā, i hoʻokaʻawale ʻia i 2 mau pona. Hoʻonui ʻia ka ʻōmole mua a hiki i ka ʻeha ʻana o ka ʻeha, ma ka awelika a hiki i ka 400-800 mg o ka carbamazepine i kēlā me kēia lā. Ma hope o kēlā, i kekahi mahele o nā mea maʻi, hiki ke hoʻomau ʻia ka mālama ʻana me kahi hoʻohaʻahaʻa ʻana i lalo o ka nui o ka 400 mg o ka carbamazepine.
Ua kuhikuhi ʻia ka retlepsin retard i nā mea maʻi a me nā mea maʻi e pili ana i ka karabamazepine ma kahi hoʻomaka mua o 100 mg carbamazepine (1/2 papa 200 mg) 2 mau manawa i ka lā.
ʻEha i ka maʻi neuropathy maʻi.
ʻO ka awelika o kēlā me kēia lā he 200 mg o ke kakahiaka a me 400 mg o ka carbamazepine i ke ahiahi. I nā hihia kūʻokoʻa loa, hiki ke kuhikuhi ʻia ka lāʻau hōʻula ʻo Finlepsin i loko o kahi pāʻina 600 mg o ka carbamazepine 2 mau manawa i ka lā. ʻO ka hoʻopaʻapaʻa Epileptiform i nā sclerosis lehulehu.
Oh
ʻO ka awelika o kēlā me kēia lā he 400 - 800 mg o ka carbamazepine, i hoʻokaʻawale ʻia i 2 mau pona.
Hoʻomaʻamaʻa a me ke pale aku i ka maʻi maʻi
ʻO ka ʻōmua mua, kahi mea e kū like ai i kahi mālama mālama, ʻo ia ʻo 200-400 mg o ka carbamazepine i kēlā me kēia lā. Inā kūpono, hiki ke hoʻonui ʻia kēia lāʻauʻau i 800 mg o ka carbamazepine i kēlā me kēia lā, i hoʻokaʻawale ʻia i 2 mau pāheʻe.
Ma muli o ka hōʻike a me ka pane kūʻokoʻa o ka mea maʻi i ka lāʻau lapaʻau. Hana ʻia ʻo Epilepsy i ka lōʻihi. Pono ke kauka loea e hoʻoholo i ke hoʻololi ʻana o ka mea maʻi i ka retard Finlepsin, ka lōʻihi o ka manawa a me kona kāpae ʻia i kēlā me kēia hihia. Hiki ke hoʻemi ʻia ka hopena o ka lāʻau lapaʻau a wehe ʻole paha i ka hoʻokaʻawale ʻana ma mua o ka hala ʻana o kahi makahiki o 2-3 o ka holo ʻana.
Hoʻopauʻia ka mālamaʻana e kahi emi hōʻemi o ka hopena o ka lāʻau no 1-2 mau makahiki. I kēia hihia, pono e noʻonoʻo nā keiki i ka hoʻonui ʻana o ka paona kino. ʻAʻole pono ke koi ʻo nā Electroencephalogram.
I ka mālamaʻana i ka neuralgia, ua haʻi ʻia e kuhikuhi i ka retard Finlepsin i loko o kahi wai e hoʻonanea ai i ka ʻeha, no nā hebedoma. Ma ke hoʻohaʻahaʻa ʻana i ka ʻona, pono ia e hoʻoholo i ka hiki o ke hoʻi ʻana i nā hōʻailona. Me ka hoʻomaha hou o ka ʻeha, hoʻomau ʻia ka mālama ʻana me kahi maʻi mālama.
ʻO ka lōʻihi o ka mālama ʻana i ka ʻeha ma ka neuropathy maʻi diabetes a me nā mea hoʻihoʻi epileptiform i nā ʻōpū he nui e like nō no ka neuralgia.
Hoʻomaʻamaʻa ka hopena ʻo Finlepsin retard syndrome i ka hōʻemi ʻoki ʻana i ka wai me ka hoʻohaʻahaʻa nui ʻana i ka wā 7-10 mau lā.

ʻO nā mea mālama palekana

ʻO Finlepsin Retard - kahi lāʻau lapaʻau no ka mālamaʻana i ka epilepsy series series dibenzazepine. He ona antidepressant, antipsychotic, vasopressin-like action. I loko o ka poʻe me ka hōʻino kino o peripheral, hōʻike ʻia e nā bouts o ka hōʻeha i ka puʻu internal i loko o kahi nerve, hōʻike i kahi hopena analgesic. ʻO ka hopena pharmacological ma muli o ka hana ʻole ʻana o nā kao sodium-sensitif ka hopena, ma muli o ke kuhi ʻana i ka membranes o nā neuron ʻoluʻolu nui loa, e hoʻomau ʻia ana ka hanauna o nā neʻe a me nā hoʻokipa ʻana o nā pulpula ma nā synapses. Mālama i ka glutamate, kahi waikele amino me ka hana o kahi neurotransmitter, mai ke komo ʻana i ka lumi intercellular, a hoʻokuʻi i ka paepae lawaiʻa o ka lolo, ma laila e hana ai i ka hopena antiepileptic. Hoʻololi i kahi kahe transembrane hoʻoikaika hou loa o nā papa paʻakai. I ka poʻe e hōʻeha nei i ka epilepsy (ma mua o nā keiki a me ka ʻōpio), ka lāʻau lapaʻau e hōʻemi i ka hopohopo, ka nui o ka hōʻikeʻana i nā mea hoʻonāukiuki, pau ka hoʻonāukiuki, a nalo ka hoʻonāukiuki. Ka hopena ma ka hana cognitive a me nā hiʻohiʻona psychomotor i hoʻoholo ʻia e ka hopena o ka lāʻau i lawe ʻia. Hoʻomaka ka hopena anticonvulsant i ka pae mai nā hola 3-4 i kekahi mau lā (i kekahi mau kūlana - a hiki i 30 lā). Me kahi maʻi hangover, hoʻokuʻu i ka kua i ka paepae no ka hopu i ka cerebral, i hoʻemi ʻia e ka waiʻona, kaohi ʻana i nā hōʻailona hoʻihoʻi (e hoʻopau ana i ka excitability nui, nā wīwī komo ʻole o nā manamana lima, e hoʻōla ai i ka gait).

Hōʻike ka hopena antipsychotic ma hope o nā lā 7-10. Kēia manawa lōʻihi e hana ai i ka hana ma ke ala e pili ai i ke kāohi ʻana o ke dopamine a me ka metabolepono norepinephrine. ʻO Finlepsin Retard kahi palapala hana lōʻihi e hana ana i kahi pae mau o ka ikaika hana i ka plasma me ka neʻe o ka hoʻokele o nā manawa 1-2 i kēlā me kēia lā. Me ka hoʻokolohua waha o ka lāʻau lapaʻau, lohi ka lāʻau akā paʻa i ka gastrointestinal tract (ʻo ka hele ʻana o nā meaʻai i loko o ka ʻeha gastrointestinal ʻaʻohe hopena o ka hopena o ka wikiwiki a me ka piha o ka huina). Mau ka ʻike neʻe o ka mea hana i loko o ke koko i mālama ʻia i nā hola 32 ma hope o ka hoʻokele ʻana. ʻO ka hapa hapalua e noho nei ma kahi o 70 mau hola. ʻO ka kāpae ʻia mai ke kino e lawe ʻia ana e nā keiki a me kahi, ʻoi aku ka liʻiliʻi ma o nā ʻōpū. ʻO ka manawa intake ka hele ʻana a ma hope koke iho o ka ʻaʻa ʻana. Loaʻa ia e haʻalele i ka papahele a i ʻole ʻāpana o ia i ka wai ma mua o ka hoʻokele ʻana: ʻaʻole i loaʻa ka lōʻihi o ka lāʻau lapaʻau mai kēia. Multiplicity o ka hoʻokomo - 1-2 mau lā i ka lā. Hoʻomaka ka papa lāʻau lapaʻau me ka liʻiliʻi liʻiliʻi i kēlā me kēia lā me ka hoʻonui pinepine ʻia i loko a hiki i ka hoʻokō ʻia ʻana o kahi pane therapeutic i loaʻa.

Lapaʻau

ʻO ka lāʻau antiepileptic i hele mai i ka iminostilbene tricyclic. Ke manaʻoʻiʻo ia e pili pū ana ka hopena anticonvulsant me ka hoʻokaʻawale ʻana i ka hiki o nā neurons e mālama i kahi kiʻekiʻe o ka hiki ke hana hou ʻia ma o ka hana sodium. Eia kekahi, ʻo ka paleʻana o ka hoʻokuʻu ʻana o ka neurotransmitter e ke kāohi ʻana i nā kanika sodium presynaptic a me ka hoʻomohala ʻana o nā hana e hana ai, ʻo ia hoʻi e hōʻemi ai i ka lawe aku ʻana i ka synaptic, he mea nui ia.

Loaʻa ia ia nā hopena antimaniacal, antipsychotic hopena, a me kahi hopena analgesic no ka hōʻeha o ka neurogen. ʻO GABA ka mea i hoʻohui ʻia, ka mea i pili me nā ʻāpana kalaka, hiki i nā lawelawe ke hana o ka hana, a ʻo ka hopena o ka carbamazepine ma nā ʻōkuhi o ka neurotransmitter modulator he nui nō hoʻi.

ʻO ka hopena antidiuretic o ka carbamazepine e pili ana me ka hopena hypothalamic ma osmoreceptors, i hoʻokaʻawale ʻia e ka neʻe ʻana o ADH, a pili pū kekahi i nā hopena koʻikoʻi i nā tubula renal.

Lapaʻau lāʻau

Ma hope o ka lawelawe ʻana i ka waha, ua hoʻopau like ʻia ka carbamazepine mai ka ʻōpala ʻana. ʻO ka pilina loa i ka protein plasma he 75%. He mea hoʻonāukiuki ia i nā aʻalima a me ka hoʻoulu ʻana i kona ake ponoʻī.

ʻO T 1/2 he 12-29 mau hola. Ua 70% ka mea i hoʻopuka ʻia i loko o ka urine (ma ke ʻano like o nā metabolite ʻole) a me 30% me nā feces.

E hoʻokuʻu i ke ʻano

Nā papa mana lōʻihi mai ke keʻokeʻo a i ke keʻokeʻo me kahi hāpana melemele, hoʻopuni piha, ka laulā, me nā kihi beveled, me nā laina hewa i hoʻopiha ʻia me nā ʻaoʻao ʻelua a me 4 nicks ma ka ʻaoʻao ʻaoʻao.

Nā mea hoʻihoʻi: kahi copolymer o ka ethyl acrylate, methyl methacrylate a me kaethethylammonioethyl methacrylate (1: 2: 0.1) (Eudragit RS30D), triacetin, talc, he copolymer o ka waikawa methacrylic a me ka ethyl acrylate (1: 1) (Eudragit L30D-55), microcine paʻahau magnesium.

10 kamepiula - nā kāmele (5) - nā kāʻei o ke kāleka.
10 kamepiula - nā kīpaha palemona (5) - nā ʻeke pepa.
10 kamepiula - nā kīpaha palemona (3) - nā ʻeke pepa.
10 kamepiula - nā kīpaha palemona (4) - nā ʻeke pepa.

E hoʻonohonoho hoʻokahi. I ka wā e lawe kolohe ai no nā pākeke a me nā ʻōpio he 15 a ʻoi aku ka makahiki, ʻo ka hopena mua loa he 100-400 mg. Inā kūpono, a noʻonoʻo i ka hopena lapaʻau, hoʻonui ʻia ka lāʻau lapaʻau ma mua o 200 mg / lā me kahi manawa o 1 pule. ʻO ka holo pinepine o ka hoʻokele he 1-4 mau manawa / lā. ʻO ka dosis mālama mālama maʻamau ʻo 600-1200 mg / lā i kekahi mau koina. Ma muli o ka hōʻike ʻana i ka hōʻike, ka pono o ka mālama ʻana, ka pane a ka mea maʻi i ka lāʻau.

I nā keiki ma lalo o ka 6 mau makahiki, ʻo 10-20 mg / kg / lā e hoʻohana ʻia ana i ka mahele i 2-3 mau ʻāpana, inā pono a me ka noʻonoʻo ʻana i ka ahonui, hoʻonui ʻia ka pāʻai e ʻoi aku ma mua o 100 mg / lā me kahi manawa o 1 hebedoma, ʻo ka nui o ka mālama mālama ʻia 250 -350 mg / lā a ʻaʻole iʻoi aku i 400 mg / lā. ʻO nā keiki i hala 6-12 mau makahiki - 100 mg 2 mau lā / lā i ka lā mua, laila hoʻonui ʻia ka nui e 100 mg / lā me kahi 1 mau pule. a hiki i ka hopena kūpono loa, ʻo ka maʻi mālama ma ka maʻamau ʻo 400-800 mg / lā.

Nā kuʻuna nui loa: i ka wā e lawe ai ma ka ʻōlelo maʻamau, ʻo nā pākeke a me nā ʻōpio he 15 mau makahiki a ʻoi aku - 1.2 g / lā, nā keiki - 1 g / lā.

Hoʻohui

Me ka hoʻohana like ʻana o ka poʻe pale o ka isoenzyme CYP3A4, hiki i ka nui o ke kaila o ka carbamazepine i loko o ke koko koko.

Me ka hana like o nā inducers o ka pūnaehana isoenzyme CYP3A4, hiki ke hoʻolōʻihi i ka metabolism o nā carbamazepine, e hoʻemi ana i kona kahe ʻana i ka plasma koko, a hoʻoemi i ka hopena therapeutic.

Me ka hoʻohana pinepine ʻana o ka carbamazepine e hoʻonāukiuki i ka hana o ka anticoagulants, ka waika folic.

Me ka hoʻohana like ʻana me ka waika valproic, kahi emi mai o ke kao o ka carbamazepine a me kahi hoʻēmi nui ʻana i ka ʻike ʻana o ka waika valproic i loko o ke kōpana koko. I ka manawa like, ʻoi ka ʻike o ka metabolama o ka carbamazepine, kāliaamaamaamaamaamaama, akā ua hoʻonui ʻia nā hopena ʻokoʻa - ʻike kūmaha ka ʻaoʻao. hōpuhi, hoʻopuka, nāwaliwali, nystagmus. Me ka hoʻohana like ʻana o ka pā pono valproic a me ka carbamazepine, hiki i ka hoʻomohala ʻana o ka hopena hepatotoxic (ʻike ʻia, ma muli o ke kūkulu hou ʻana o ka metabolite lua o ka wai valproic, he hopena hepatotoxic).

Me ka hoʻohana pinepine ʻana, hoʻemi ka valpromide i ka hana metabolism i loko o ke ake o ka carbamazepine a me kāna metabolite carbamazepine-epoxide ma muli o ke kaohi ʻana o ka hydroxase epoxide. ʻO ka metabolite i koho ʻia me ka hana anticonvulsant, akā me ka hoʻonui nui o ka neʻe plasma e hiki iā ia ke loaʻa i ka hopena oʻa.

Me ka hoʻohana pū ʻana me ka verapamil, diltiazem, isoniazid, dextropropoxyphene, viloxazine, fluoxetine, fluvoxamine, cimetidine, acetazolamide, danazole, desipramine, nicotinamide (i nā pākeke, eia wale nō ma nā wahi kiʻekiʻe), erythromycin, tromaandromy, tromyandromy, tromyandromy me ka itraconazole, ketoconazole, fluconazole), terfenadine, loratadine, ka nui ʻana o ka ʻai ʻana o ka carbamazepine i loko o ka mū koko he hiki me ka hopena o ka hopena o nā ʻokoʻa (dizziness, drowsiness, ataxia, diplopia).

Me ka hoʻohana like ʻana me ka hexamidine, ua nāwaliwali ka hopena anticonvulsant o ka carbamazepine, me ka hydrochlorothiazide, furosemide - hiki iā ia ke hōʻemi i ka hoʻōkena sodium i loko o ke koko, me nā mea hoʻohālikelike hormonal - hiki iā ia ke hoʻonāwaliwali i ka hopena o nā contraceptives a me ke kūkulu ʻana o ke kaila acyclic.

Me ka hoʻohana like ʻana me ka hormone thyroid, hiki ke hoʻonui i ka hoʻopau ʻana o nā hormone thyroid, me ka clonazepam, hiki ke hoʻonui i ka hoʻomaʻemaʻe ʻana o nā clonazepam a hoʻēmi i ka hoʻomaʻemaʻe o ka carbamazepine, me ka hoʻomākaukau ʻana o lithium, hiki i ka hoʻonui pū ʻana o nā hopena neurotoxic.

Me ka hoʻohana like ʻana me ka primidone, hiki ke hoʻoneʻe iho nei i ka ʻike o ka mau ʻoama ma ka lāʻauama i loko o ke koko plasma. Aia kekahi mau manaʻo e hoʻonui paha ka primidone i ka hoʻoliʻi plasma o ka metabolite hoʻoikaika i ka pharmacologically - carbamazepine-10,11-epoxide.

Me ka hoʻohana pinepine ʻana me ka ritonavir, hiki ke hoʻonui ʻia ka hopena ʻaoʻao o ka carbamazepine, me ka sertraline, a hiki ke hōʻemi i ka pae ʻana o ka sertraline, me ka theophylline, rifampicin, cisplatin, doxorubicin, hiki ke hōʻemi i ka manaʻo o ka carbamazepine i loko o ke koko he hiki, me ka tetracycline, hiki i nā hopena o ka carbamazepine.

Me ka hoʻohana like ʻana me ka felbamate, hiki ke hoʻohaʻahaʻa i ka manaʻo o ka carbamazepine i loko o ke kaila koko, akā hiki ke hoʻonui ʻia i loko o ke kao o ka metabolite hoʻoikaika o ka mau ʻoama o ka carbamazepine-epoxide, aʻo ka hoʻēmi ʻana i ka neʻe i loko o ka plasma o felbamate.

Me ka hoʻohana like ʻana me ka phenytoin, phenobarbital, ke emi nei ka ʻike ʻana i ka carbamazepine i loko o ke koko koko. ʻO ka palupalu mutual o ka hana anticonvulsant hiki, a i nā hanana liʻiliʻi, ʻo kona hoʻoikaika.

Nā hopena hopena

Mai ka ʻaoʻao o ka pūnaehana nīkini, a me nā ʻōnaehana o peripheral: pinepine i ka manawa, ka ataxia, ka hiamoe, ke poʻo, ka diplopia, ka hopena hoʻonaninani, hiki ke hoʻowalewale i ka neʻe ʻana mai, nā hanana, a me nā pilikia o nā hanana oculomotor, dysarthria, neuritis peripheral, paresthesia, ʻōpū palupalu, hōʻailona paresis, halapaa, hopohopo, luhi, hoʻoweliweli, ʻūhā, ʻike ʻole ʻia, hoʻonui i ka psychosis, ʻeha hoʻomaʻamaʻa, conjunctivitis, tinnitus, hyperacusis.

Mai ka pūnaehana hana ʻana: nausea, hoʻonui ʻia GGT, nui ka hana o ka phosphatase alkaline, luaʻi, waha maloʻo, ʻuʻuku - hoʻonui i ka hana o ka transaminases, jaundice, hepatitis cholestatic, ʻeha a i ʻole constipation, i kekahi mau hihia - hoʻemi i ka momona, ʻeha o ka ʻōpū, glossitis, stomatitis.

Mai ka pūnaehana cardiovascular: loaʻa - pilikia ʻole ka haunaele myocardial, i kekahi mau hihia - bradycardia, arrhythmias, AV blockade me ka syncope, nānaka, ka hewa puʻuwai, nā hōʻike o ka poʻina coronary, thrombophlebitis, thromboembolism.

Mai ka papa hemopoietic: leukopenia, eosinophilia, thrombocytopenia, jarang - leukocytosis, i kekahi mau hihia - agranulocytosis, anemia aplastic, erythrocytic aplasia, megaloblastic anemia, reticulocytosis, hemolytic anemia, granulomatous hepatitis.

Mai ka ʻaoʻao o ka hana o ka metabolism: hyponatremia, mālama i ka wai, edema, loaʻa ka nui, hoʻohaʻahaʻa i ka osmolality plasma, i kekahi mau hihia - huʻipiʻi intermittent koʻikoʻi, nā waiʻona folic, ʻoki kino metabolism, hoʻonui i ka cholesterol a me ka triglycerides.

Mai ka pūnaehana endocrine: gynecomastia a galactorrhea, ʻaʻole pilikia - thyroid dysfunction.

Mai ka ʻōnaehana urinary: jarang - hana ʻole nā ​​māla o ka hana, interstitial nephritis a me ka pana ʻole ʻole.

Mai ka papa hana hanu: ma kekahi mau hihia - dyspnea, pneumonitis a pneumonia paha.

He maʻi kūloko: ke ana o ka ʻili, kaʻeha, līpeke - lymphadenopathy, maʻi, ka hepatosplenomegaly, arthralgia.

ʻO Epilepsy: nui, kīwaha, kāwili ʻia (me ka nui a me ka nui kumu hoʻokele) epileptic. ʻO ka maʻi ʻeha e loaʻa mai i ka neʻe ʻana mai ka neurogen, me ka pono neuralgia trigeminal, trigeminal neuralgia i loko o ka lehulehu sclerosis, pono glossopharyngeal neuralgia. ʻO ka pale ʻana i ka hoʻouka ʻana me ka maʻi haʻalele hauwa. ʻO nā psychoses kūpono a me nā skizoaffective (me ke ʻano o ka nānā ʻana). ʻO ka neuropathy Diabetic me ka ʻeha. ʻO ka maʻi maʻi indipidus o ke kumu waena, polyuria a me polydipsia o ke ʻano neurohormonal.

ʻŌpū a me ka lactation

Inā pono, e hoʻohana i ka wā o ka wā ʻo ka wahine hāpai (ʻoi aku hoʻi i ka trimester mua) a i ka wā lactation e noʻonoʻo pono i nā pōmaikaʻi o ka mea i manaʻo ʻia no ka mālama ʻana i ka makuahine a me ka pilikia i ka wahine hāpai a i ʻole keiki. I kēia hihia, ʻōlelo ʻia ka carbamazepine e hoʻohana wale ʻia e like me ka monotherapy i nā lāʻau koʻikoʻi liʻiliʻi.

Manaʻo nā wahine o ka hānau keiki ʻana i ka wā o ka mālama ʻana me ka carbamazepine e hoʻohana i nā contraceptives non-hormonal.

Nā ʻōlelo kikoʻī

ʻAʻole hoʻohana ʻia ʻo Carbamazepine no ka lawe pōkole epileptic liʻiliʻi a i ʻole ka lehulehu, lawe ʻana i ka make myoclonic aicic poiki epileptic. ʻAʻole pono e hoʻohana pono e hōʻoluʻolu i nā ʻeha maʻamau, ʻo ia kahi prophylactic i ka manawa lōʻihi o ke kala ʻana i nā neuralgia trigeminal.

Hoʻohana ia me ka mālama pono i nā maʻi concomitant o ka maʻi cardiovascular, paʻa i ke kino ikaika a me / a hana paha i ka hana ʻana, ka maʻi diabetes mellitus, i hoʻonui ʻia ke kaila intraocular, me ka mōʻaukala o ka hematological kūlia i ka hoʻohana ʻana i nā lāʻauʻokoʻa ʻē aʻe, hyponatremia, noho hoʻomau i ka urinary, a me ka hoʻonui nui ʻana i ka antidepressants tricyclic. , me nā hōʻike ʻana o ka mōʻaukala o nā hōʻoki ʻana i ka mālama ʻana o ka lāʻau carbamazepine, me nā keiki a me nā maʻi maʻi.

Pono e hana ʻia ka lāʻau lapaʻau ma lalo o ka nānā o kekahi kauka. Me ka lōʻihi o ka mālama ʻana, pono e mālama i ke kiʻi o ke koko, ke kūlana hana o ke akeʻa a me nā ʻōpū, ke ʻike ʻana o nā electrolytes i ka plasma koko, a me kahi hoʻokolokolo ophthalmological. Hoʻomaopopo iki ka manawa o ka pae o ka carbamazepine i loko o ke kaila koko e nānā i ka pono a me ka palekana o ka mālama ʻana.

Ma kahi o 2 mau pule ma mua o ka hoʻomaka ʻana o ka lāʻau caramazepine, pono ia e pani i ka mālama ʻana me ka MAO inhibitors.

I ka wā mālama o ka mālama ʻana, ʻaʻole i ʻae ʻia ka hoʻohana ʻana i ka waiʻona.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a kāohi i nā mīkini

I ka wā o ka mālama ʻana, pono e pale kekahi i ka hana ʻana i nā hana e hikiʻole ai ke koi nui ana, a me ka wikiwiki o ka hopena psychomotor.

mea lāʻau lapaʻau . ^ E Ha yM. ʻO ka retard Finlepsin kahi mea hoʻopalike anticonvulsant o ka iminostilbene tricyclic. Hōʻike ia i ka hana antiepileptic, neurotropic a me psychotropic. ʻO ka hopena therapeutic ka mea nui ma muli o ka pale ʻana i ka hoʻoili ʻia o ka synaptic o ka hoihoi, a ma muli o ke ʻano o ka hoʻohaʻahaʻa ʻana i ka hōʻeuʻeu ʻana o nā manaʻo hoʻomahaʻe. I nā paʻapū kiʻekiʻe, ʻo ka carbamazepine e hōʻemi ai i ka emi ʻana o ka potentiation post-tetanic. ʻO ka hāleau Finlepsin e hōʻemi i ka nui o ka hōʻeha ma nā neuralgia trigeminal. ʻO kēia hopena ma muli o ke kaohi ʻana o ka hoʻopili synaptic o ka hoʻonāukiuki i ka nul o ka pōkole o ka nerve trigeminal. Me ka maʻi insipidus diabetes, he hopena antidiuretic ʻo retardid, ka hopena ma ka hopena hypothalamic ma osmoreceptors.

Lapaʻau lāʻau Ma hope o ka lawelawe waha, ua hoʻoulu ʻia ka carbamazepine a kokoke loa.

ʻO ka hapalua hola he 8.5 mau hola a loaʻa kahi ākea (e pili ana i 1.72-12 mau hola). Ma hope o hoʻokahi pākahi o C max, ka carbamazepine i loko o ke kaila koko i ka pākeke i hiki ke kūpaʻa ma hope o 4-16 mau hola (maʻa loa ma hope o 35 mau hola), i nā keiki ma hope o nā hola 4-6. i ka wa e hoʻohana ai i nā hōkeo kiʻekiʻe, ʻo ke kaʻe o ka kukuna plasma ke ʻano o kahi pākuʻi.

I ka manawa e hoʻohana ʻia nā papa lōlō i ka manawa lōʻihi, he haʻahaʻa haʻahaʻa haʻahaʻa o ka carbamazepine i loko o ke kaila koko ma mua o nā papa maʻamau.

Loaʻa ka ʻai kaulike ma hope o 2-8 lā. ʻAʻohe mea pili kūpono ma waena o ke ʻano o ka hopena o ka carbamazepine a me kahi paʻa paʻa i ka kūʻē o ke kaila o ke koko.

E pili ana i ka hoʻōla a me nā pehu o ka carbamazepine i loko o ke kaila koko, ua hōʻike ʻia e hāʻule paha ka holo ʻana me kahi pae plasma o 4-12 μg / ml. Hōʻike ka ʻike o ka lāʻau i ka plasma koko ma o ka 20 μg / ml, hoʻonui i ke kiʻi o ka maʻi.

ʻO ka hāleʻa Finlepsin i kahi paʻa o ka waiwai i ka hoʻoliʻi koko o 5-18 μg / ml e hoʻopau i ka ʻeha o ka neuralgia trigeminal.

Hoʻopili ka 70-80% o nā carbamazepine i nā protein plasma. ʻO ka mahele o ka carbamazepine unbound me nā protein i ka ʻike ʻana o 50 g / ml e paʻa mau ana. ʻO 48-53% o nā lāʻau lapaʻau hoʻolaʻa hoʻolaʻa lāʻau a ka lāʻau lapaama-10, 11-epoxide a paʻa i nā protein plasma. ʻO ka paʻa o nā carbamazepine ma CSF ʻo 33% o ka kaila o ka plasma.

E hele ana ʻo Carbamazepine i ka pale wai ma ka ʻāʻī waiū.

Ma hope o ka lawe ʻana i hoʻokahi pākahi, hoʻāla ʻia ka carbamazepine mai i ke koko koko me nā hola T ½ 36. Me ka mālama lōʻihi loa, hoʻoemi ʻia ʻo T ½ e 50% ma muli o ke kaakomo o ka hoʻoliʻiliʻi o microsomal.

I nā poʻe olakino olakino, ʻo ka huina o ka hoʻokahe koko mai ma kahi o 19,8 ml / h / kg kino kino, i loko o nā mea maʻi me ka monotherapy - e pili ana i ka 54.6 ml / h / kg, i nā mea maʻi me ka hana hoʻohui - e pili ana i ka 113.3 ml / h / kg

Ma hope o ka lawelawe waha hoʻokahi o ka carbamazepine, ʻo 72% o ka nui i ka lāʻau i loko o ke ʻano o nā metabolites e hoʻopiʻi ʻia mai ke kino e nā keiki. Hoʻopili ʻia ke koena 28% me nā loina, hapa - ʻaʻole i loli. ʻO 2-3% wale nō o kahi mea i hoʻopuka ʻia i loko o ka urine, ʻaʻole i hoʻololi ʻia ka carbamazepine.

epilepsy: pākuʻi a i ʻole nā ​​hapa waiwai ʻokoʻa (me ka ʻole o ka nalowale o ka ʻike ʻole) me a ʻole ʻole o ka mana ʻōlima, ko nā mea poʻomanaʻo tonic-clonic, nā ʻano waiwai like ʻole.

Hiki ke hoʻohanaʻia ʻo retlepsin retard e like me monotherapy a ma ke ʻano he hui hoʻohui.

ʻO nā kūlana o ka maʻi manic, kākoʻo paʻa no ka maʻi bipolar affective e pale ai i ka exacerbations a i ʻole e hōʻemi i ka nui o nā hōʻike klinikino o ka exacerbation.

ʻO ka hōʻailona o ka haʻaleleʻana i ka waiʻona.

Idiopathic trigeminal neuralgia a me nemegia trigeminal i loko o ka lehulehu sclerosis (maʻamau a me ka atypical).

Idiopathic neuralgia o ka lau glossopharyngeal nerve.

ʻO ka retard Finlepsin i kuhikuhi ʻia ma ka maʻamau, ʻo ka maʻamau ka mahele o ka lā i kēlā me kēia lā i ʻelua. Hiki iā ʻoe ke lawe i ka lāʻau lapaʻau i ka wā o ka ʻai ʻana, a i ʻole ma waena o ka papaʻaina, me kahi liʻiliʻi o ka wai wai.

Ma mua o ka hoʻomaka ʻana i ka mālama ʻana, e ʻike ʻia nā mea maʻi e pili ana i ka pūʻulu moʻomeheu Kina Han a me nā mea maʻi o ka poʻe kumu mai Thai, inā hiki, ke nānā ʻia no ka HLA-B * 1502, no ka mea, hiki i kēia allele ke hoʻonāukiuki i ka hoʻomōhala ʻia o ka maʻi ʻeha ʻo Stevens-Johnson e pili ana i ka maʻi.

Epilepia Hoʻomaka ka mālama ʻana i ka hoʻohana ʻana o kahi laima haʻahaʻa i kēlā me kēia lā, kahi e hoʻonui lohi ʻia (hoʻoponopono ʻia, ka noʻonoʻo ʻana i nā pono o kēlā me kēia maʻi pākuʻi) a hiki i ka hopena hopena.

I nā hihia kahi e hiki ai, pono ʻo Finlepsin retard e kuhikuhi i ka monotherapy, akā i ka wā e hoʻohana ai me nā lāʻau lapaʻau ʻē aʻe, kahi hoʻoponopono no ka hoʻonui nui ʻana i ka hopena o ka lāʻau. Inā hoʻohui ʻo Finlepsin i ka lāʻau antiepileptic i loaʻa, pono e hoʻonui iki ʻia ka nui o nā lāʻau, akā ʻo nā loli o nā lāʻau lapaʻau i hoʻohana ʻia ʻaʻole i loli a hoʻoponopono ʻia inā pono.

No ka koho ʻana i ka palena kiʻekiʻe o ka lāʻau lapaʻau, pono e hoʻoholo i ke kiʻekiʻe o ka mea ikaika i ka punela koko. ʻO ka hoʻomohala ʻana i ka hopena o ka lāʻau i loko o ke koko koko he 4-12 μg / ml.

I kekahi mau mea maʻi, me ka hoʻohana ʻana i nā papa hoʻokele, pono paha e hoʻonui i ka hopena o ka lāʻau.

Nā pākeke ʻO ka dosis mua i ʻōlelo ʻia e 100-200 mg 1-2 mau lā i kēlā lā, a laila e hoʻonui mālie ka nui a hiki i ka hopena kūpono loa, ʻo ka maʻamau maʻamau ka lā nui o 800-1200 mg, ka mea i hoʻokaʻawale ʻia i 2 mau dosis. Ke koi nei kekahi mau mea maʻi i kahi kaila o ka hope retle o Finlepsin i hiki ke 1600 mg a i ʻole 2000 mg / lā.

Nā maʻi maʻi maʻi. Hāʻawi i nā pili o ka lāʻau lapaʻau a me nā ʻano lāʻau lapaʻau like ʻole o ka lāʻau antiepileptic, pono e koho ʻia nā mea maʻi ma ka mālama ʻana i nā palanikua o nā finlepsin.

Na keiki mai ko 5 mau makahiki. ʻO ka maʻamau, pono e mālama ʻia ka mālama ʻana ma kahi maʻa o 10-20 mg / kg momona kino o kēlā me kēia lā (i nā nui hemo).

Mua mau makahiki 5-10 makahiki - 400-600 mg / lā.

Nā kamaliʻi 10-15 - 600-1000 mg / lā.

Nā kūlana manic a me ke kōkua kākoʻo ʻana i nā pilikia o ka hoʻopili (bipolar). ʻO ka awelika dosis ka 400-1600 mg / lā ma 2 mau puʻupuʻu i hoʻokaʻawale ʻia.

ʻO ka maʻamau, ke lawe ʻia nei ka lāʻau i ka maʻa o ka 400-600 mg / lā i 2 mau puʻupuʻu i hoʻokaʻawale ʻia. I ka mālamaʻana i nā kūlana manic, e hoʻonui nui ʻia ka lāʻau o Finlepsin retard i 800 mg / lā. Me ka mālama mālama ʻana no ka maʻi bipolar, e hoʻonui ʻia ka nui o ka pehu haʻahaʻa e hōʻoia i ka ʻae ʻana.

Hōʻemi hōʻaila alkohol. ʻO ka awelika nui he 600 mg / lā ma 2 mau puʻupuʻu i hoʻokaʻawale ʻia. I nā hihia koʻikoʻi, hiki ke hoʻonui ʻia ke kuʻi i nā lā mua (e like me, a hiki i ka 1200 mg / lā, i hoʻokaʻawale ʻia i 2 mau kāmela). I ka hōʻike nui o ka hoʻokaʻawale ʻana i ka waiʻona, hoʻomaka ka mālama ʻana me ka hui pū ʻana o ka hōʻulu ʻana o Finlepsin me nā lāʻau lapaʻau sedative-hypnotic (no ka laʻana, clomethiazole, chlordiazepoxide), pili i nā ʻōlelo aʻoaʻo ma luna. Ma hope o ka pau ʻana o ka hana ʻoi, hiki ke hoʻomau ʻia ka mālama ʻana me ka hāleau Finlepsin e like me ka monotherapy.

Idiopathic trigeminal neuralgia a me nemegia trigeminal i loko o ka lehulehu sclerosis (maʻamau a me ka atypical). Idiopathic neuralgia o ka lau glossopharyngeal nerve. ʻO ka helu mua o ka Finlepsin Retard he 200-400 mg / lā (100 mg 2 mau manawa i kahi lā no nā maʻi maʻi). Pono e hoʻonui malie a hiki i ka ʻeha ʻana o ka ʻeha (maʻa mau a hiki i kahi ʻano o 400-800 mg, hoʻokaʻawale ʻia i 1-2 mau pona). I kekahi mau hihia, pono ke koi ʻia kahi maʻi o kēlā me kēia lā he 1600 mg. Ma hope o ka hoʻopauʻana o ka hōʻeha, pono e hōʻemi ʻia ka nui o ka mālama i ka mālama liʻiliʻi.

ʻAʻole pono ke kauoha iā Finlepsin Retard:

• me nā hypersensitivity paʻa i ka carbamazepine a i nā mea lāʻau like me nā mea kanu (tricyclic antidepressants), a i nā mea'ē aʻe o ka lāʻau lapaʻau,
• me ka poloka AV,
• ka mōʻaukala o ka ae ʻana o ka hana momona o ka iwi,
• nā mea maʻi me ka mōʻaukala o ka pphyria hepatic (e. g.
• i ka hui me MAO inhibitors,
• i ka hui pū me voriconazole, me he mea maikaʻi ʻole ka mālama ʻana.

i nā hanana e pili ana i ka hopena i hana pinepine ʻia me ka hoʻokaʻawale ʻana me ke ʻano monotherapy. Mahalo i ka nui a ma ka mua ma ka hoʻomaka ʻana o ka mālama ʻana, hiki paha kekahi mau hopena ʻaoʻao. Ma keʻano holoʻokoʻa, nalo lākou ma luna o lākou iho ma hope o 8-14 mau lā a ma hope o ka hōʻemi iki ʻana i ka pona hoʻēmi.

Ma ka ʻāpana o ke koko a me ka papahana lymphatic: leukocytosis, eosinophilia, leukopenia, thrombocytopenia, kakī i ka waikawa folic, agranulocytosis, anemia aplastic, pancytopenia, erythrocytic aplasia, anemia, megaloblastic anemia, piritahi intermittent porphyria, maʻi hemiboli peka, variemative porphyria hemorrhage.

Mai ka pānaʻi: drug rashes with eosinophilia and systemic sintomas (DRESS), lohi i ka hypersensitivity multi-organ with fever, ʻāwili keʻokeʻo, vasculitis, lymphadenopathy, hōʻailona hōʻailona like lymphoma, arthralgia, leukopenia, eosinophilia, hepatosplenomegaly, a me nā hopena abnormal i loko o nā ʻano like ʻole, nā huaʻōlelo like ʻole nā kēna hua bile (ka luku a me ka nalowale o nā kaile bile intrahepatic), nā meningitis aseptic me myoclonus a me eosinophilia peripheral, anaphylactic he hopena, angioedema, hypogammaglobulinemia. Nā hui ʻē aʻe (e.g., ate, māmā, kidney, pancreas, myocardium, intestinal) paha i pili ai.

Mai ka hoʻonā endocrine: ʻO ka edema, kaohi o ka wai, ka loaʻa ʻana o ka paona, hyponatremia a me ka hoʻohaʻahaʻa ʻana i ka osmolarity plasma koko ma o ka hopena o ka carbamazepine, e like me ka hana o ka hormone antidiuretic, e hoʻomaka ana i ka hyperhydration, i hui pū ʻia e ka lethargy, ka luaʻi, ka ʻeha, ka hōʻeha a me ke kuʻuna o ka neurological, hoʻonui i nā pae prolactin me. ʻaʻohe make o nā maʻi lapaʻau e like me galactorrhea a me gynecomastia, nā hopena abnormal o nā hoʻāʻo ʻana o ka thyroid: he hōʻemi ma ka pae o L-thyroxine (FT 4, T 4, T 3) a me ka hoʻonui ʻana iā TSH. ka mea maʻamau e hele ʻole me nā hōʻike kulana, ka hannahule o nā iwi i ke kīpē (he hōʻemi i ka calcium o ka plasma a me ka 25-hydroxycolecalciferol i loko o ke koko koko, ke alakaʻi nei i ka osteomalacia / osteoporosis, he hoʻonui i ka cholesterol, e komo pū me HDL cholesterol a me ka triglycerides. ʻO ka emi ʻana o nā pae o ka plasma o ka waiū B 12 ma lalo o ka hopena o ka carbamazepine a me ka hoʻonui ʻana i ka pae o ka homocysteine ​​ua hōʻike pū ʻia hoʻi.

Mai ka ʻaoʻao o ka metabolism a me nā maʻiʻai: hemahema folate, hoemi iho la i ka momona, porphyria haohao, porphyria paʻa ʻole.

Mai ka ʻaoʻao mai o ka psyche: hallucinations (ʻike a i ʻole auditory), kaumaha, nele i ka ʻai, hopohopo, ke ʻano kūwaho, ka huhū, ke komo ʻana o ka hoʻopukapuka ʻana, haunaele, nui ka maʻi psychosis, loli ʻano, e like me ka kaumaha a me ka manic mood swings, phobias, nele o ka hoʻowalewale, hoʻoweliweli kūlike o ke ʻano, huakai.

Mai ka ʻōnaehana hoʻonāukiuki: nāwaliwali laulā, dizziness, ataxia, drowsiness, sedation, luhi, headache, abnormal reflex movement (e.g. tremor, coarse tremor, dystonia, tic), nystagmus, orofacial dyskinesia, lohi noʻonoʻo, noʻonoʻo ʻōlelo (e.g. dysarthria a slurred speech), choreoathetosis, peropheral neuropathy, paresthesia, nāwaliwali o ka naʻau a me ka paresis, ka hoʻōla ʻana o ka maʻi, nā maʻi antipsychotic syndrome, kahaha ʻana o ka hoʻomanaʻo, ka maʻixica a me ka cerebellar, i hui pū ʻia i ka wā me ka ʻeha. E ʻeha ʻoe.

Mai ka ʻaoʻao o ke kino o ka hihiʻo. conjunctivitis, noho kīnā (diplopia, ʻike hoʻopuka), hoʻonui i ke koʻikoʻi intraocular, ʻohu ana o nā lens, retinotoxicity, nā kuhi oculomotor.

Mai ka ʻaoʻao o ka io o ka lohe a me nā mea pono vestibular: ka hoʻopuka ʻana i ka maʻi, tinnitus, tinnitus, hyperacusis, hypoacusia, ʻike papaha o ka pitch.

Mai ka pūnaehana cardiovascular: Hōʻalo ʻia ka intracardiac conduction, bradycardia, arrhythmia, ka ulu ʻana o ka maʻi ʻōpū coronary, ka puʻuwai naʻau congestive, puʻuwai lele, AV blockade me syncope, hypertension a hypotension, vasculitis, thrombophlebitis, thromboembolism (e.g. pulmonary embolism).

mai ke ʻano o ka māmā, i hōʻike ʻia e ka piʻi ʻana o ke ʻano wela o ke kino, pōkole o ka hanu, pulmonitis a i ʻole nā ​​maʻi ʻa. Ma kahi o kēlā mau hopena hypersensitivity, e hoʻihoʻi pono i ka lāʻau.

ka hoʻohaʻahaʻa ʻana i ka momona, ka malo maloʻo, ka lua, ka luaʻi, ka ʻeha, ka constipation, ka ʻeha o ka ʻōpū, stomatitis, gingivitis, glossitis, pancreatitis, colitis.

ʻO ka maʻi Hepatobiliary: nā hoʻololi i nā mākau o ka hōʻike hana maʻemaʻe (hoʻonui i nā pae o ka hoʻolaʻa gamma-glutamyl, nui ka kiʻekiʻe o ka phosphatase alkaline, transaminases), jaundice, nā ʻano ʻano hepatitis (cholestatic, hepatocellular, granulomatous, kāwili ʻia), ka hoʻoweliweli ʻana i ke ola hepatitis akene, hana hoʻopiʻi.

Ma ka ʻāpana o ka ʻili a me ka momona subcutaneous: dermatitis allergic, urticaria, pruritus, dermatitis exfoliative, erythroderma, necrosis o ke ʻano superficial me ka blistering (syndrome o Lyell), photosensitivity, reddening o ka ʻili me nā rashes polymorphic i ke ʻano o nā ʻōpū a me ke ʻano o nā nodes, me ka hemorrhages (e exudative erythema multhemae, Stevens-Johnson), nā ʻāpana petechial i loko o ka ʻili a me ka lupus erythematosus (hoʻolaha i ka lupus erythematosus, alopecia), diaphoresis, nā hoʻololi i ka pigmentation kino, ʻeha, ka hirsutism, vasculitis, pu pura, mahuahua sweating, huʻi generalized exanthematous pustulosis (AGEP), lichenoid keratosis, onihomadez.

Mai ka ʻōnaehana musculoskeletal: arthralgia, myalgia, uaua kīwaha, eha ʻōpū, hōʻeha, hoʻemi i ka hoʻokaʻawale ʻana o nā iwi mineral.

Mai nā pūpū a me ka maʻi urinary: proteinuria, hematuria, oliguria, dysuria, pollakiuria, mālama i ka urinary, tubulointerstitial nephritis, renal gagal, hoʻonui ʻia urea / azotemia, pinepine urination.

Mai ka ʻōpiopio a me nā kinipona momona: ka hoʻokaʻawale ʻana o spermatogenesis (me ka hoʻēmi ʻana i ka helu a / a i ʻole motility spermatozoa), erectile dysfunction, impotence, hoʻoemi i ka makemake moekolohe.

Nā maʻi a me nā infestations: ʻO ka hoʻonā hou ʻana o nā maʻi herpes manu type VI.

Hoʻoiho o ka hopena hōʻike hōʻike laboratorium: hypogammaglobulinemia.

Pono ke kaukaila ʻana i ka lāʻau ʻoama ma lalo o ka mākaʻi o ke olakino, aia wale nō ma hope o ka loiloi ʻana i ka pōmaikaʻi o ka pōmaikaʻi / a me ka nānā ʻana i ka mālama pono ʻana i nā poʻe maʻi me ka mōʻaukala o ka cardiac, hepatic a renal impairment, hematological a me ke ʻano he mau lāʻau lapaʻau ʻē aʻe, a i nā mea maʻi me ka haukapila haukapila.

Hōʻike ka Carbamazepine i ka hana anticholinergic haʻahaʻa, no laila, ʻo nā mea maʻi me ka piʻi ʻana o ka intraocular koʻikoʻi e pono e hōʻike ʻia a kūkākūkā i nā mea hiki ke pilikia.

Pono e hoʻomanaʻo ʻia e pili ana i ka hiki ke hoʻopaʻa ʻia o nā psychose latent, a me ka pili i nā poʻe maʻi maʻi - e pili ana i ka hiki ke hiki o ka haunaele a me ka hoʻomohala ʻana o ka hopohopo.

ʻOi aku ka maikaʻi o ka lāʻau no nā absences (lawe liʻiliʻi ʻia) a me nā makana myoclonic. Ua hōʻike kekahi mau hihia i ka piʻi ʻana o nā Seizure i loko o nā mea maʻi me ka nele o ka atypical.

Nā hopena Hematologic. ʻO ka hoʻohana ʻana i ka lāʻau pili me ka hoʻomohala ʻana i ka agranulocytosis a me ka anemia aplastic, akā ma muli o ke ʻano haʻahaʻa o kēia mau kūlana, paʻakikī ke loiloi i ka hopena koʻikoʻi inā lawe i ka carbamazepine.

Pono e ʻike ʻia nā mea maʻi e pili ana i nā hōʻailona o nā palapu a me nā hōʻailona o nā maʻi hematologic hiki loa, a me nā hōʻailona no ka dermatological a me nā hopena ate. Hoʻomaʻamaʻa ʻia ka mea maʻi ma ka hopena o nā hopena e like me ke kuni, ke ʻehaʻeha, ka ʻili o ka ʻili, ka ʻāʻīlī wahaʻa, kūʻai ʻole i ka wā e hiki mai ai, pinpoint hemorrhages a hemorrhagic purpura, pono e kūkā koke ʻoe i kahi kauka.

Inā emi iki ka nui o nā leukocytes a i ʻole platelets i ka wā o ka hōʻola, pono e nānā pono ʻia nā kūlana o ka mea maʻi, a pono pū ʻia kahi hōʻike koko maʻamau o ka mea maʻi. Pono e hoʻoneʻe ʻia ka lāʻau me ka caramazepine inā kūkulu ka mea maʻi i ka leukopenia, ka mea i hoʻopilikia nui ʻia, holomua, a i ʻole pū me nā hōʻailona olakino, e like me ke kaʻe a me ka ʻehaʻeha. Pono e hoʻohana ʻia ka hoʻohana ʻana i ka carbamazepine inā ʻike ʻia nā hōʻailona o ka pale ʻana i ka hana o ka mahi a nā iwi.

ʻO ka manawa maʻamau a pinepine paha kahi lōlō a ʻohi ʻole paha ma ka helu o nā platelets a i ʻole leukocytes e pili ana me ka lawe ʻana i ka carbamazepine. Eia nō naʻe, no ka hapa nui o kēia mau hihia, ua hōʻoia ʻia ko lākou kino i ka manawa a ʻaʻole lākou e hōʻike i ka hoʻomohala ʻana o ka anemia aplastic a i ʻole agranulocytosis. Ma mua o ka hoʻomaka ʻana i ka hoʻolaʻa a me nā manawa maʻamau i ka wā e hana ai, pono e hoʻokō ʻia kahi hōʻike koko, me ka hoʻoholo ʻana o ka helu platelet (ʻoiai pū, ka nui o ka reticulocytes a me ka pae o ka hemoglobin).

ʻO nā hopena dermatological kūpono. ʻO nā hopena dermatological koʻikoʻi, me ka toxic epidermal necrolysis (TEN) a i ʻole syndrome o Lyell, ʻo Stevens-Johnson syndrome (SJS), nā mea ʻilihune me ka carbamazepine. ʻO nā maʻi me nā hopena dermatological koʻikoʻi e koi paha i ka hoʻomaha, no ka mea, hiki i kēia mau kūlana ke hoʻoweliweli a loaʻa i kahi hopena momona. Hoʻoulu ka hapa nui o nā SJS / TEN i nā mahina mua o ka mālama ʻana i ka carbamazepine. Me ka hoʻomohala ʻana i nā hōʻailona a me nā hōʻailona e hōʻike ana i nā hopena dermatological koʻikoʻi (SJS, Lyell's syndrome / TEN), pono ke kāpae nei i ka carbamazepine a laila e kuhikuhi ʻia ke ʻano aʻoaʻo.

Lapaʻau lāʻau. Ua māhuahua ka hōʻike o nā hopena o nā ʻano HLA āpau ma ka makemake o ka mea maʻi no ka hoʻopiʻi ʻokoʻa me ka hoʻopili ʻana.

Ke kamaʻilio pū ʻana me (HLA) -B * 1502. Ua hōʻike ʻia nā haʻawina ʻo Retrospective i nā maʻi Kina o ka pūʻulu o ka iwi o Khan me kahi hopena i waena o nā hopena ʻili o ka SJS / TEN e pili ana i ka carbamazepine a me ka hele ʻana o nā antigen leukocyte kanaka (HLA), allele (HLA) -B * 1502 ma kēia mau maʻi. ʻO kahi hōʻike nui o nā hōʻike e pili ana i ka hoʻomohala ʻana o SJS (ʻoi aku ka liʻiliʻi ʻole) ka helehelena o kekahi mau ʻāina ma Asia (no ka laʻana, ʻo nā mokupuni o Taiwan, Malaysia a me Filipina), kahi i loaʻa ka alele (HLA) -B * 1502 ma waena o ka heluna o nā kānaka. ʻO ka helu o nā mea lawe i kēia mau mea i waena o ka poʻe o Asia he> 15% i Pilipinas, i Thailand, Hong Kong a me Malaysia, ≈10% - ma Fr. ʻO Taiwan, kokoke i ka 4% - i Northern China, ≈2-4% - ma Asia Hema (me India) a me Dosage form: & nbsp tablets Composation:

Pākaukau 1 papa:

mea waiwai : carbamazepine 200 mg a i 400 mg,

nā mea hoʻohālikelike : etyl acrylate, methyl methacrylate and trimethylammonioethyl methacrylate copolymer (Eudragit ® RS 30 D), triacetin, talc, methacrylic acid a me ka ethyl acrylate copolymer (Eudragit ® L 30 D-55), microcrystalline cellulose, rospovidone, colloidalopy.

Kūpono i hoʻokuʻu ʻia nā papa 200 mg:

400 mg paʻa i nā papa e hoʻokuʻu ai: mai ke keʻokeʻo a i ke keʻokeʻo me kahi kala melemele, nā ʻāpana poepoe i uhi ʻia me nā kihi beveled, me nā laina hewa i hui ʻia ma nā ʻaoʻao ʻelua a me nā kiʻina 4 ma ka ʻaoʻao ʻaoʻao.

ʻĀpana Pharmacotherapeutic: hui antiepileptic ATX: & nbsp

Pharmacodynamics: He lāʻau antiepileptic (dibenzazepine derivative), he loaʻa nō naʻe kahi antidepressant, antipsychotic a me antidiuretic hopena, he hopena analgesic i nā mea maʻi me neuralgia. Hoʻopili nā ka hana o ka hana me ka blockade o nā kahe sodium-gated volt, kahi e hiki ai i ka hoʻokūkū o ka membrane o nā neurons overexcited, kaohi ʻana i ke ʻano o nā kahe mai o nā neurons a me ka hoʻohaʻahaʻa i ka conduction synaptic impulse. Māhele i ka hana hou ʻana o nā pahuhopu hana holoʻokoʻa o Na + -d hilinaʻi i nā neurons depolarized. Hoʻēmi i ka hoʻokuʻu ʻana o ka mea hoʻōho a ka pelekikena o ka neurotransmitter amino acid glutamate, hoʻonui i ka hoʻohaʻahaʻa ʻana i ka paepae hoʻoiho ʻana o ka pūnaehana nīnū, a penei, e hōʻemi ana i ka loaʻa ʻana o ka waiwai pio epileptic. Hoʻonui ʻo ia i ka K + conductivity, hoʻololi i nā kaheea-gated Ca 2+ channel, hiki iā ia ke hāʻawi pū i ka hopena anticonvulsant o ka lāʻau.

He kūpono ia i ka hopu hilo (ʻāpana) maʻalahi (maʻalahi a paʻakikī), i ʻole a i ʻole hele pū ʻia me ka generalization o ke kuʻina, no ka mea hoʻomakeke a tonic-clonic, a no ka hui pū ʻana o kēia mau ʻano ʻano hana luhi (maʻa mau ka maikaʻi ʻole no ka pīhoihoi liʻiliʻi - petit mal, absences a me nā mākuʻu myoclonic. )

ʻO ka maʻi me ka epilepsy (ʻoi aku ka nui o nā keiki a me nā ʻōpio) he hopena kūpono i nā hōʻailona o ka hopohopo a me ke kaumaha, a me ka kaohiʻana o ka huhū a me ka uluʻana.

Hoʻomaopopo ka hopena i ka hana cognitive a me ka hana psychomotor. ʻO ka hoʻomaka ʻana o ka hopena anticonvulsant mai nā hola he nui i kekahi mau lā (i kekahi manawa a hiki i ka 1 mahina ma muli o ka auto-induction o ka metabolism).

Me ka neuralgia kumuʻōlelo a koʻikoʻi, i ka hapanui ke hoʻopaʻa ʻia nei i nā ʻano o nā ʻeha hōʻeha o ka hōʻeha ʻana.

Hoʻomaopopo ka hōʻeha o ka ʻeha ma nā neuralgia trigeminal ma hope o 8-72 mau hola.

Me ka hoʻohaʻahaʻa ʻana i ka waiʻona, e hoʻonui ana i ka paepae no ka mākaukau paʻa ʻana, me ka hoʻēmi ʻia ʻana i kēia kūlana, a me ka hōʻemi ʻana i ka loaʻa o nā maʻi lapaʻau e pili ana i ka maʻi (hoʻonui i ka huhū, ka hoʻonaninani, nā hana gait).

Hoʻopilikia ka hana Antipsychotic (antimaniacal) ma hope o 7-10 lā, hiki ma muli o ke kaohi ʻana o ka metabolism o ka dopamine a me norepinephrine.

Hoʻomoe ka lōʻihi e hana i ka mea e mālama ai i ka paʻa mau o ka lāʻauamaama i loko o ke koko ke lawe ʻia ʻo 1-2 mau manawa i kēlā lā.

He lohi a pau ka holopapa (ʻo ka ʻai ʻana ʻaʻole i pili i ka helu a me ka nui o ka inu ʻana). Ma hope o hoʻokahi o ka pākaukau o ka papaʻa, hōʻea ke kūkaʻi nui loa ma hope o nā hola he 32. ʻO ke kumukūʻai kiʻekiʻe o ka lōʻihi o ke kāʻei ʻana o ka mea hana ʻole i loli ʻia ma hope o hoʻokahi wai o ka 400 mg o ka carbamazepine ma kahi o 2.5 μg / ml Loaʻa nā hoʻokolohua kūloko o ka lāʻau i loko o ka plasma ma hope o 1-2 mau hebedoma (ʻo ka nui o ka hoʻokō ka hilinaʻi i kēlā me kēia ʻano o ka metabolism: auto-induction o nā ʻōnaehana o ka hāmeʻa, hetero-induction e nā lāʻau lapaʻau i hoʻohana i ka manawa like), a me ke kūlana o ka mea maʻi, ka hopena o ka lāʻau a me ka lōʻihi o ka mālama ʻana. ʻO nā mea nui i waena o nā kūloko kūpono o ka kūloko i ka laulā therapeutic i nānā ʻia: ma ka hapa nui o nā mea maʻi, nā helu ma waena o 4 a 12 μg / ml (17-50 μmol / l). ʻO nā mea o ke kūama o ka mau ʻoama o ka carbamazepine-10,11-epoxide (ka metabolite hoʻākāka lāʻau pharmacologically) e pili ana i 30% o ka kūlike o ka carbamazepine. Ke kamaʻilio pū ʻana me nā protein plasma i nā keiki - 55-59%, i nā pākeke - 70-80%. ʻO ka ʻike ākea o ka hoʻoili he 0.8-1.9 l / kg. Hoʻokumu ʻia nā kukū i loko o ka wai a me nā lawaiʻa cerebrospinal, kahi mea i hoʻohālikelike ʻia i ka nui o nā mea kaha a me nā protein (20-30%). Penetrates ma o ka paepae placental. ʻO ka hoʻoulu ʻana i ka waiū umauma he 25-60% o kēlā me ka plasma.

Hoʻomiliʻia ia i ka ate, ka mea nui ma ka ala epoxy me ka hoʻokumu ʻana o nā metabolites koʻikoʻi: ka hoʻoikaika o ka carbamazepine-10,11-epoxide a me ka hana o ka conjugate me ka waikawa glucuronic. ʻO ka isoenzyme nui e hāʻawi ana i ka biotransformation o ka carbamazepine i ka carbamazepine-10,11-epoxide ka cytochrome P450 (CYP3A4). Ma muli o kēia mau hopena metabolic, kahi hana kekahi o ka metabolite o ka 9-hydroxymethyl-10-carbamoylacridane, ka mea nāwaliwali kahi hana lapaʻau. hiki ke hoʻonāukiuki i kona akeʻana.

ʻO ka hapalua ola ma hope o ka nānā ʻana o kahi pākahi hoʻokahi he 60-100 mau hola (kahi awelika o kahi 70 hola), me ka hoʻohana mau ʻana, hoʻemi ʻia ka hapalua ola ma muli o ka hana o ka wili o ka pūnaehana enzyme. Ma hope o kahi kaila o ka waha o ka carbamazepine, ʻo 72% o ka nui i lawe ʻia i loko o ka pāʻai a me ka 28% me nā feces, aʻo kahi mea e lawe ana i ka 2% o ka hopena i lawe ʻia i loko o ka urine e like me ka carbamazepine i loli, a ma kahi o 1% i ke ʻano o ka metabolit 10.11-epoxy.

ʻAʻohe mea hōʻailona i ka loli o ka pharmacokinetics o ka hoʻololi o ka carbamazepine i nā mea maʻi maʻi.

ʻO ka Epilepsy: ka hopu maʻamau ma ka ʻokoʻa (me ka haʻalele ʻole), nā ʻāpana wahi o ka epilepsy (ka maʻalahi a me ka paʻakikī paʻakikī), nā kuʻuna ākea ākea.

Neula,

Iuralopathic glossopharyngeal neuralgia,

ʻO ka ʻeha me ka hoʻopilikia o ka nerve peripheral i ka maʻi mellitus, ka ʻeha ma nā maʻi neuropathy maʻi,

ʻO ka hoʻohālikelike Epileptiform me ka sclerosis lehulehu, nā māka huakaʻi me ka neuralgia trigeminal, koikoi tonic, ʻōlelo paroxysmal a me ka neʻe piʻoloke (paroxysmal dysarthria a me ataxia), nā paresthesias paroxysmal a me nā hōʻeha o ka ʻeha.

Hōʻemi ka hakahaka Alkohol (hopohopo, hoʻomālamalama, hyper excitability, hiamoe a hiamoe),

Nā maʻi noʻonoʻo (kahakaha a me nā maʻi o schizoaffective, ʻuhane, nā pilikia o ke ʻōnaehana limbic).

ʻO ka hypersensitivity i ka carbamazepine a me nā mea ʻē aʻe o ka lāʻau, a me ka tricyclic antidepressants,

Hōʻeha ʻia nā maʻi heula hematopoiesis (anemia, leukopenia),

Ana porphyria pākuʻu keu (me ka mōʻaukala)

ʻO ka mālama māmā ʻana o ka mākau lithium a me nā inhibitors MAO.

Decompensated pilikia hōʻalo,

Hōʻailona hyponatremia (ADH hypersecretion syndrome, hypopituitarism, hypothyroidism, adrenal cortex insufficiency),

Nā hemahema o ka ate a me ka hana hana,

Ka hana wai kūlohelohe (hoʻonui i ke kaumaha o CNS, hoʻonui i ka metabolama o ka carbamazepine),

ʻO ka hōʻike ʻana o ka hematopoiesis pumehana o ka iwi me ka lāʻau lapaʻau (mōʻaukala),

Hāpai a nā pilipila

Hoʻonui nā kikoo intraocular,

I ka hui pū me nā sedative-hypnotics.

ʻLelo ʻia a me ka lactation:

I ka manawa hiki, ʻōlohelohe ʻo Finlepsin® i ka wahine o ka nui o ka hānau ʻana i ke ʻano o ka monotherapy, ma ka hopena haʻahaʻa loa, no ka mea ʻoi aku ka maʻi maʻamau o nā mea hou mai nā makuahine i lawe i ka mālama antiepileptic hui ʻia ma mua o ka monotherapy.

I ka wā e loaʻa ai ka hapai, pono e hoʻohālikelike i ka pono o ka lapaʻau ʻia a me nā hoʻopiʻi hiki paha, ʻoi aku hoʻi i ka trimester mua o ka hāpai ʻana.Ua ʻike ʻia na keiki o nā makuahine e loaʻa ana i ka epilepsy i predisposed i ka ulu ulu ʻana o ka hana hōʻeuʻeu a me ke kino, me ka malformations. Hiki i ka retard Finlepsin® ke hoʻonui i ka hopena o kēia mau pilikia. Aia nā hōʻike kūʻokoʻa i nā hihia o nā maʻi a me nā malformations, e komo me ka pani ʻole ʻana o nā araka vertebral (spina bifida).

Hoʻonui ka lāʻau antiepileptic i ka nele o ka folic acid, i ʻike pinepine ʻia i ka wā hāpai, hiki iā ia ke hoʻonui i ka nui o ka hānau ʻana o ka hānau ʻana i nā keiki, no laila, ʻo ka lawe ʻana i ka waikawa folic e ʻōlelo ʻia ma mua o ka wahine i hoʻolālā ʻia a i ka wā hāpai. I mea e pale ai i nā hoʻopiʻi hemorrhagic i loko o nā mea hou, ʻo nā wahine i nā hebedoma hope o ka hāpai ʻana, me nā pēpē hou, ua ʻōlelo ʻia e kuhikuhi i ka vitamina K1.

Hōʻalo ka Carbamazepine i ka waiū umauma, no laila ʻo nā pōmaikaʻi a me nā hopena i makemake ʻole ʻia e like me nā hopena o ka umauma pono e hoʻohālikelike me ka hoʻomau ʻana i ka maʻi maʻamau. Me ka umauma hoʻomau i ka wā e lawe nei i ka lāʻau lapaʻau, pono ʻoe e hoʻokumu i ka nānā ʻana no ke keiki e pili ana i ka hiki ke hoʻomohala ʻana i nā hopena ʻino (ʻoi aku ka hoʻohālikelike, ke kaumaha ikaika, ʻomaʻomaʻi a me nā maʻi ʻokoʻa).

Nā ʻoslelo a me ke hoʻoponopono:

I loko, i ka manawa a ma hope o ka ʻai ʻana, inu i nā wai he nui.

No ka maʻalahi o ka hoʻohana ʻana, hiki i ka papaʻa (a i ʻole a i ʻole hapa a i ʻole hapaha ʻia) ke hoʻoheheʻe ʻia mua i ka wai a i loko paha o ka wai wai, ʻoiai ka waiwai o ka hoʻokuʻu ʻana o ka mea hana ma hope o ka hoʻoilina ʻana i ka papa ma kahi wai. ʻO ka pae o nā pona i hoʻohana ʻia he 400-1200 mg i kēlā me kēia lā, kahi i kau ʻia ai ma 1-2 mau wai no ka lā.

Pono e hoʻonui ka nui o ka lā ma mua o 1600 mg.

I ka manawa hiki, pono ʻo retlepsin® retard e kuhikuhi i ka monotherapy. Hoʻomaka ka hoʻolālā ma ka hoʻohana ʻana i kahi liʻiliʻi o kēlā me kēia lā, kahi e hoʻonui mālie a hiki i ka hopena maikaʻi loa. ʻO ka hoʻohui ʻana o ka loina o Finlepsin® i kahi hoʻomau antiepileptic e hana pono, e hana lōkū ʻia, ʻoiai nā loli o nā lāʻau lapaʻau i hoʻohana ʻia a i ʻole, inā pono, e hoʻoponopono ʻia. Inā poina ka mea maʻi e lawe i kahi ma hope o ke ʻano o ka lāʻau lapaʻau i ka manawa kūpono, pono koke e lawe ʻia ka nui hala i ka manawa ua ʻike ʻia kēia hala ʻole, a pono ʻoe e lawe i ka pālua ʻelua o ka lāʻau.

ʻO 200 dosis ka mua ma mua o 200 i kēlā me kēia lā, a laila e hoʻonui mālie ka nui a hiki i ka hopena kūpono loa. ʻO ka lāʻau mālama mālama he 800-1200 mg i kēlā me kēia lā, i hoʻokaʻawale ʻia i nā dosis he 1-2 i kēlā me kēia lā.

ʻO ka dosis mua no nā keiki mai 6 a 15 mau makahiki he 200 mg i kēlā me kēia lā, a laila e hoʻonui iki ʻia ka nui o ka 100 mg i kēlā me kēia lā a hiki i ka hopena kūpono loa.

Nā hōʻailona no ka hoʻohana ʻana

Finlepsin ua noiia no kekahi mau maʻi me ka:

• neuralgia
• epilepsy
• nā kūlana kūlike ʻole
• nā kūlana psychotic
• huki waiʻona

Hana ke kauka i kahi koho pilikino i holoʻokoʻa e like me nā kuhikuhi a me nā hōʻike olakino. ʻAʻole hoʻokaʻawale ʻia ke alakaʻi iho ʻana o ka lāʻau i ka lāʻau.

Nā Hoʻohui

ʻAʻole ʻōlelo ʻia ʻo Finlepsin no:

• ka kūʻauhau ʻana o kekahi kanaka i kekahi o nā ʻāpana a i ʻole ka ʻāʻū i mua o ka atidepressants (tricyclic)
• ka hoʻohana ʻana o ka ʻohi MAO a i ʻole ka hoʻomākaukau ʻana o ka lithium
• nā maʻi hōʻeha o ka iwi hematopoiesis
• AV blockade
• palia phpoli

Me ka minamina nui, kau ʻia nā papa no ka:

• me nā paleʻole o nā pūpū, nā ate, nā ʻōnaehana cardiovascular
• nā maʻi maʻi maʻi
• ka hoʻohana ʻana me ka wīwī a i ʻole nā ​​lāʻau hiamoe
• māhuahua i ke koʻikoʻi (intracranial, intraocular)
• nā maʻi prostate
• ka ʻaloʻakā maʻi

Loaʻa i ka ʻaoʻao o ka noi Finlepsin hiki ke hoʻolilo i nā ʻōlelo kuaki no ka hoʻohana ʻana, no ka laʻana, he overdose. I kēia mau hōʻokoʻa, nā hana haunaele i ka hana o nā ʻōnaehana a me ka hoʻonaninani endocrine, a me ka ʻōnaehana hematopoietic hoʻi, hiki ke hoʻomaopopo. ʻO ka hiki ʻole ke hoʻokō i nā ʻōlelo aʻo i loko o kēia embodiment ka mea e hoʻonā wale ʻole i nā maʻi pōkole wale nō ma ke ʻano o ke poʻo a me ka maʻi nausea, akā ʻo nā maʻi ʻē aʻe nō hoʻi: leukocytosis, leukopenia, etc.

Finlepsin aia ka basamazepine nui (ʻo ka waiwai nui) a me nā ʻāpana kōkua: magnesium stearate, gelatin, croscarmellose sodium, MCC, etc. a ʻo ke ʻano o ka hoʻokuʻu i ka lāʻau nā papa. No ka mea, ua hoʻolako ʻia ka lāʻau lapaʻau e lawe wale ʻia e ke kauka a i mea piha i nā ʻōlelo aʻoaʻo.

Nā papa ʻaina Finlepsin: nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana

Finlepsin nā papa e like me nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, pono ʻia no ka hoʻoponopono waha, me ka ʻole o ka haʻi ʻana i ka ʻai. Aia i ka paʻakikī o nā kūlana a i ʻole nā ​​maʻi a me ke kiʻi o ka maʻi maʻamau, hiki ke kuhikuhi ʻia i nā pākeke ma ka liʻiliʻi he 200 mg (1 papa, ka laʻi mua ʻana), ʻo ka mālama mālama ʻia ke kau ʻana i ka lāʻau i ka wai ma loko o 800-1200 mg i kēlā me kēia lā (i hoʻokaʻawale ʻia i kekahi mau doka). ʻO ka dosage ka uku kiʻekiʻe loa ʻo 1.2-2 g. Ma mua o ka pauʻana o ka papa, e hoʻemi iki ʻia ka nui o ka lāʻau. Wahi a nā ʻōlelo kuhikuhi, hiki i kahi hōʻiliʻili kolohe ke loaʻa i nā hopena maikaʻi ʻole. ʻO nā keiki, ma ke kumu o nā hōʻailona, ​​ua ʻākena ʻia e hoʻomaka i ka lawe ʻana me ka lāʻau lapaʻau "Finlepsin Kūleʻa "i kahi hapa o 200 mg (analogue).

Me ka neuralgia e hiki iaʻu ke lawe?

Kōkua ʻo Finlepsin me ka neuralgia trigeminal, akā ua ʻōlelo kekahi mau mea maʻi nā mea i hōʻea i ka apathy, ka mea i hōʻemi ai i ka kamaʻilio pūnaewele. I kekahi hihia, hana ʻia ke koho e kekahi loea, no laila, inā i ʻike ʻia nā hopena maikaʻi ʻole (ʻaoʻao), pono ʻoe e kāpae i ka lawe ʻana i ka lāʻau lapaʻau a nīnau hou i kāu kauka.

I ka wā hāpai a me nā keiki?

I ka wā hāpai, hoʻohālikelike ʻia nā wahine, inā hiki, monotherapy i ka palena iki (ʻohi ʻia me kekahi lāʻau lapaʻau). Hoʻopili kēia i ka hopena o ka pathen congenital o ka hopena o ka pūpū. ʻO ka koho ʻana o kahi papa komo e hoʻoholo ʻia e nā kauka komo wale nō, e pili ana i nā ʻano kuhikuhi o ka mea maʻi. Hōʻike ʻia nā loiloi like, e like me nā ʻōlelo i hoʻohana ʻia, i ka wā lactation.

ʻO ke kuhikuhi ʻana i nā mea i makemake ʻia no nā keiki Finlepsin Kūhiʻi (analogue) i nā papa o ka nui o ka 200 mg:

• 1-5 mau makahiki - ʻo ka nui loa ka nui o ka nui o ka 400 mg i kēlā me kēia lā (hoʻomaka e lawe, e hoʻonui lohi ana i ka momona mai 200 i ka hōʻike ʻia 400 mg)
• 6-10 - nui i kēlā me kēia lā nui o 600mg
• 11-15 mau makahiki - ʻae ʻia i kēlā me kēia lā o 1000 mg

Finardpsin Kauhau

Wahi a nā kuhikuhi i ka hoʻohana Finlepsin Hoʻomaka lākou e lawe pono i ka retard, e hoʻonui mālie ana i ka ʻonanona. Hoʻokomo ʻia ka dosis ma nā hōʻailona: ka uha o ka maʻi, ke ʻano o ka hōʻike ʻana, ka makahiki a me nā ʻano o ke kino. I kekahi mau hihia, hiki iā ia ke hoʻololi Finlepsin Ke hoʻi aku nei i ka analogue, eia nō naʻe, hiki i ke kauka ke hana i kēia hoʻoholo hoʻoholo.

ʻO Finlepsin a me nā waiʻona kūpono?

Ua hōʻike ʻia ʻo ia ka mea hana nui o ka lāʻau lapaʻau e hōʻemi i ka hopena o ka ethanol. Eia nō naʻe, e like me nā ʻōlelo i hoʻohana ʻia, ʻaʻole pono ia e hoʻohui i nā papa me ka hoʻohana ʻana i nā mea inu wai - ka hoʻoweliweli ʻana o ka hopena o nā ʻaoʻao a hiki i nā hoʻopiʻi koʻikoʻi.

ʻO nā mea kikoʻī nui o ka lāʻau Finlepsin (nā papa):

• Kalaunaka
• Zeptol
• Acterval
• ʻĀnipola
• Zagretol
• Kōkua

Hiki i ke kauka hele wale nō ke kuhikuhi i nā hōʻailona a kuhikuhi i ka mea hoʻohana no ka hoʻohana ʻana. Wahi a nā ʻōlelo kuhikuhi no ka hoʻohana ʻana, ʻaʻole koʻikoʻi ʻia ka hoʻokele pono ʻana.

Ehia nā kumukūʻai kūʻai?

ʻO ka lāʻau lapaʻau kahi hāpana a hāʻawi ia wale ʻia ma ka lāʻau lapaʻau. Ke kumukūʻai o ka lāʻau lapaʻau e loli ana ma waena o 200-280 mau rubles (e pili ana i ka dosis a me ka margin pharmacy).

Nā hōʻailona no ka hoʻohana ʻana Finlepsin nui loa. Kuhi nā poʻe loea i kona hana koʻikoʻi ma ka mālama i nā ʻano o nā kūlana a me nā maʻi me ka mālama pololei i nā ʻōkuhi, e like me kā lākou loiloi maikaʻi ʻana.

Hoʻohālikelike nā loiloi o ka maʻi maʻi e like me nā hopena o nā kauka, akā ma ka hana pono, nā hopena e like me ka emi ʻana o ka hana naʻauao, i ʻole ka mana o nā mea ʻē aʻe, a me nā mea ʻē aʻe.

ʻO ka hanana Finlepsin

Hāʻawi ka mea hana i kahi lāʻau lapaʻau i ke ʻano o nā papa i loaʻa he 200 mg o ka carbamazepine ma ke ʻano he mea hoʻoikaika. He hopena kēia mau mea ma nā pūpū o ka lolo, e pale ana i ka hōʻea ʻana o nā neʻe nuna. Ma muli o kēia, hāʻawi ʻo Finlepsin i nā hopena therapeutic e like me:

• anticonvulsant, me ka epilepsy,
• anti-manic, hoʻemi i ka hopohopo, huhū, hōʻike ʻia o ke kaumaha;
• ʻaʻano no ka hoʻōla ʻana o nā ʻano hana like ʻole o ka ʻōnaehana hae, ma ka hoʻohālike me ka neuritis.

Hāʻawi ʻia ka lāʻau lapaʻau hoʻi no ka mākaukau e hoʻokau ʻia e ka maʻi haʻalele, kahi i hoʻoiho ʻia e ka maʻi ʻakaʻaka.

Hōʻike ʻia ka Finlepsin no nā maʻi aʻe:

• epilepsy, me ka pili o kona mau helehelena hui,
• e kūpaʻa ʻia e epileptiform me ka ulu ʻana o ka sclerosis lehulehu, paresthesia, diazartria a me nā ala ʻē aʻe,
• ʻeha me ka neuritis a me ka hōʻino ʻana i nā nipili peripheral, me ka hoʻonāukiuki ʻia e ka maʻi maʻi,
• neuralgia o kahi kumu ʻike ole,
• nā maʻi noʻonoʻo ʻole, me ka mea hoʻi e hoʻonāukiuki ʻia e ka hoʻohuna o ke kino,
• ma ke ʻāpana o ka mālama ʻana i nā hōʻailona no ka haʻalele.

He nui nā contraindications i ka lāʻau lapaʻau, no laila hiki ʻole iā ʻoe ke hoʻohana me ka ʻole o ka ʻōlelo a ke kauka. I waena o nā kūlana o ke kino no ka mea ʻaʻole i ʻōlelo ʻia e hoʻohana iā Finlepsin i ka hematopoiesis, ka atrioventricular block, porphyria, a me nā kūloko pilikino i nā mea o ka lāʻau lapaʻau.

E kū'ē i ke ʻano o ka mālama ʻana me Finlepsin, hiki i ka hoʻomohala ʻana o nā hopena maikaʻi ʻole mai ka hana ʻana i ke kūwī, ka nūnū, ka naʻau o ka cardiovascular, ka endocrine, nā genitourinary system, nā musculoskeletal system, nā pūnao sensory a me ka hoʻokumu ʻana i ke koko. He lōʻihi ka papa inoa o nā hopena ʻaoʻao. Inā loaʻa kekahi mau hōʻailona maikaʻi ʻole, e pani i ka lawe ʻana i nā papa a e ʻōlelo aku i kahi kauka.

ʻAʻole ʻōlelo ʻia ʻo Finlepsin inā aia kahi kipi o ke kūkulu ʻana i ke koko, ka atrioventricular block, porphyria, kūlia pilikino i nā mea o ka lāʻau.

Ke hoʻohālikelike huakaʻi

Hoʻohālike nā lāʻau lapaʻau i ka hapanui o kēia nui, akā he mau ʻokoʻa.

Loaʻa nā hoʻomākaukau no ka papa hana like me ia, loaʻa nā hōʻailona like no ke hoʻohana. ʻAʻole lākou e manaʻo no ka hoʻohana ʻana me nā kūlana like kino a me ka ala pathological o ke kino. ʻO nā hopena ʻaoʻao e hiki i ka lāʻau lapaʻau e like pū me.

Hoʻokomo ʻia nā lāʻau lapaʻau e kekahi mea hana - ka hui transatlantic Teva. Loaʻa nā lāʻau ʻelua i ke kau inoa.

Poke? I? O man?

ʻOkoʻa ka ʻokoʻa Finlepsin ʻokoʻa ma mua o ka mea i hana ma mua o ka hana lōʻihi. Hoʻokahi i loko o ke kino, e hoʻokuʻu pilikino ʻia kona mau māhele, no ka mea ʻo ka mālama ʻana o nā lāʻau e mālama ʻia no ka manawa lōʻihi. Hoʻopilikia kēia i nā hopena ʻaoʻao - ua emi ka hopena o ko lākou ulu ʻana.

ʻO ka retard Fininpsin e hoʻoulu i nā hopena he nui, ʻo ka nausea, ka luaʻi, ka hiamoe, nā pilikia, a me nā pilikia ʻike.

Nā Hōʻike Hoʻomaʻi

ʻO Marina, 27 makahiki, ʻo Ryazan: “Pono wau e hālāwai me Finlepsin i ka wa i hopu ai ka makuakāne makuahonua kāne. ʻAʻole ia he epileptic, akā ua like like me ia. Ua kuhikuhi aku ke kauka i kēia lāʻau lapaʻau, me ka ʻōlelo ʻana ua hoʻohana ʻia ʻaʻole wale nō e nā mea maʻi me ka epilepsy wale nō, akā ʻo nā mea me nā mea hoʻokūkū kiʻekiʻe. Ka hoʻomaka ʻana o ka makuahōnōwaiola i nā lāʻau lapaʻau, akā hoʻomaka ka hoʻopiʻi ʻana o ka haunaele mau loa a me ka pohā. Pono au e hoʻi i ke kauka nāna i kuhikuhi iā retlepsin retard. Ua ʻae maikaʻi ʻo Papa i kēia mau penikala. ”

ʻO Irina, he 41 makahiki, ʻo Voronezh: “Ua kauoha ʻia ʻo Finlepsin i kāna kāne ma hope o kahi hōʻeha hemorrhagic. Manaʻo ka wahine i nā peni no ka mahina ʻelua. ʻAʻoleʻo ia e hoʻopiʻi i ka hopena maikaʻi. Maikaʻi maikaʻi ka kāne, hōʻoia ke kauka i ka hopena o ka hopena.

Hōʻike nā kauka i nā mea hoʻokele Finlepsin lāua ʻo Finlepsin

Igor, nā mea lapaʻau, 45 mau makahiki, ʻo Nizhny Novgorod: "ʻO nā lāʻau lapaʻau ʻelua e mālama pono ʻia, e ʻae ʻia e nā mea maʻi. He kumukūʻai kūpono. ”

ʻO Vladimir, neurologist, 51 ona makahiki, ʻo Bryansk: "Ma muli o ka maʻi a me ke ʻano o ke olakino o ka mea maʻi, ke kuhikuhi aku nei au iā Finlepsin a i kāna hoʻohālikelike i ka hana lōʻihi. Ke manaʻoʻiʻo nei au ua maikaʻi nā lāʻau ʻelua. ʻO nā hopena ʻaoʻao, akā hikiʻole, inā hoʻopiʻi ka mea maʻi i nā ʻōlelo lapaʻau. ʻO kahi mea hoʻohui ʻia ke kumu o nā lāʻau lapaʻau: ua loaʻa i ka kokoke loa o nā mea a pau. ”