Amitriptyline Nycomed - nā ʻōlelo aʻoaʻo no ka hoʻohana

Amitriptyline Nycomed: nā ʻōlelo e hoʻohana ai a e loiloi

ʻAno inoa: Amitriptyline-Nycomed

ATX Code: N06AA09

ʻO kēiaʻano hana: amitriptyline (Amitriptylinum)

Mea Hana: Takeda Pharma A / S (Denmark), ʻO Nycomed Danmark ApS (Denmark)

Hoʻouka i ka wehewehe a me ke kiʻi: 10/22/2018

ʻO nā kumukūʻai ma nā lāʻau lapaʻau: mai ka 54 mau rubles.

Amitriptyline Nycomed - kahi lāʻau lapaʻau me ka hana antidepressant.

E hoʻokuʻu i ke ʻano a me ka ʻano

Nā palapala kiko o ka hoʻokuʻu ʻana o Amitriptyline Nycomed:

• nā papa ʻaina (50 mau ʻāpana i kēlā me kēia i loko o nā ipu aniani o ka ʻalani, 1 pahu i loko o kahi pahu pahu.
• nā papa ʻaina ʻoniʻoni: keʻokeʻo, biconvex, pōʻai (50 kēlā me kēia i loko o nā kīʻaha pohihihi, 1 pahu i loko o ka pūlima pepa.

ʻO ka mea hana i ka hana o 1 papa, nāʻaila / hoʻopuni kiʻi ʻia: amitriptyline - 10 a i ʻole 25 mg.

ʻO nā mea kōkua i ka helu pūpū o ka papa pālani: microcrystalline cellulose, polypropylene glycol, starch potato, magnesium stearate, lactose monohydrate, titanium dioxide, talc, methyl hydroxypropyl cellulose, starch corn, gelatin, croscarmellose sodium, purified polyvidone.

ʻO nā mea kōkua i ka hoʻohui o 1 papa, hoʻopaʻa ʻia nā kiʻi (10/25 mg):

• core: magnesium stearate - 0.25 / 0,5 mg, povidone - 0.83 / 0.6 mg, talc - 2.25 / 4.5 mg, microcrystalline cellulose - 9.5 / 18 mg, kāpena kūleta - 28 , 2/38 mg, ka lōpoti lactose - 27 / 40.2 mg,
• shell: propylene glycol - 0.2 / 0.3 mg, titanium dioxide - 0.8 / 0.9 mg, hypromellose - 1.2 / 1.4 mg, talc - 0.8 / 0.9 mg.

Lapaʻau lāʻau

ʻO Amitriptyline Nycomed kekahi o nā antidepresi tricyclic mai ka pūʻulu o nā mono-non-selective reuptake inhibitors. Ua hōʻike ʻia ia nā hana timoanaleptic a me sedative.

Hoʻopili ʻia ka hana o ka hana me ka hoʻonui ʻana i ka ʻike o ka serotonin a me nā norepinephrine i ka cleapt synaptic i ka ʻoihana sentral. ʻO ka hōʻiliʻili ʻana o kēia mau neurotransmitters ma muli o ke kaohi ʻana o ko lākou hopu hou ʻia e nā membranes o nā neurons presynaptic.

ʻO Amitriptyline kahi mea huna o nā ʻorslelo alpha-1-adrenergic, H1-histamine receptor, M1- a me M2-muscarinic cholinergic receptor. Ma muli o ke kumu i kapa ʻia ʻo ka monoamine hypothesis, aia kahi pilina ma waena o ka hana o nā neurotransmitters ma nā ʻāpana o ka lolo a me ka leo hoʻonaninani.

ʻAʻole i hōʻike ʻia ka hopena ma waena o ka neʻe ʻana o ka plasma ma amitriptyline i loko o ke koko a me ka hopena lapaʻau ʻaʻole hōʻike ʻia, akā hiki paha ke loaʻa ke hopena hopena maikaʻi loa ma ka neʻe ʻana mai 100 a 260 μg / L.

Loaʻa ka maʻi hōʻemi o ke kaumaha ma hope o nā 2-6 mau pule o ka mālama ʻana (ma hope o ka neʻe ʻana o ka plasma konsilibrium i loko o ke koko.

A Amitriptyline Nycomed he hopena like me ka quinidine e pili ana i ka hohonu o ka naʻau.

Lapaʻau lāʻau

ʻO Amitriptyline ma hope o ke kaʻina waha i piha a hoʻopaʻa koke ʻia mai ka gastrointestinal tract. Loaʻa i ka plasma wela (C_max) nānāʻia no 2-6 mau hola ma hope o ka hoʻokele ʻana.

ʻO ke kaila plasma o ka amitriptyline i loko o ke koko o nā mea maʻi like ʻole e loli nui. ʻO ka bioavailability o amitriptyline e like me 50%. Ma kahi o 95% o ka waihona e hoʻopaʻa ai i nā protein plasma. ʻO ka manawa e hiki ai i ka wikiwiki kiʻekiʻe (Tc_max) ma hope o ka hoʻolilo ʻana he 4 mau hola, ʻo ka neʻe o ka kūlike mea ma kahi o 7 mau lā mai ka hoʻomaka ʻana o ka hopena. Ka helu hāpili - ma kahi o 1085 l / kg. Hoʻopili ka waiwai i ka placenta a hoʻopili ʻia i loko o ka waiū umauma.

ʻO ka Metabolism e hana ai i loko o ka ate, ma kahi o 50% e hoʻāliʻi i ka wā o ka hele mua ma ka pepeka. Eia kekahi, loaʻa iā amitriptyline N-demethylation e ka cytochrome P450 me ka hoʻokumu hou ʻana o ka metabolite ikaika - nortriptyline. ʻO ka waiwai a me kāna hana neʻe i ka momona e hoʻokaʻawale i nā puʻuwai. N-hydroxy-, 10-hydroxymetabolite o amitriptyline, 10-hydroxynortriptyline he hana pū. Hoʻomili ʻia ʻo Amitriptyline a me nortriptyline me ka acid glucuronic (ʻaʻole paʻa kahi kulu). ʻO ka mea koʻikoʻi e hoʻoholo i ka maʻemaʻe o ka renal a me ka nānā ʻana o ka plasma i loko o ke koko ʻo ia ka helu o ka hydroxylation. Ma kahi liʻiliʻi liʻiliʻi o nā maʻi, ua nānā ʻia ka hydroxylation (he kūlana genetic). I ka hikiʻana o ka hana hepatic impaired, hoʻonui ka hapalua hapalua o amitriptyline / nortriptyline i loko o ke koko koko.

ʻO ka hapalua-ola (T1 / 2) o amitriptyline mai loko o ke koko koko mai 9 a hiki i 46 mau hola, ʻo nortriptyline mai 18 a 95 mau hola.

Hoʻopilikia nui ka hana maʻalahi i ke ʻano o nā metabolites e nā keiki a ma o nā mea palupalu. I loko o ke ʻano i loli ʻole, ua hoʻokaʻawale wale ʻia nā wahi liʻiliʻi o ka nui i loko o nā keiki. Me ka hana ʻole o ka renal, ʻaʻole i loli ka metabolism o ka amitriptyline a me nā nortriptyline, ʻoiai ua pau ka hiʻona. ʻO Amitriptyline mai ke kahe o ke koko ma ka dialysis ʻaʻole i lawe ʻia (ma muli o ke kamaʻilio ʻana me nā ʻōmua o ke koko).

Nā Hoʻohui

• myocardial infarction (me ka wā kahiko o ka moʻolelo)
• hoʻonāʻālua ʻili
• lilo i ka maʻi kūlohelohe,
• ka hoʻomāʻeha a me ka make ʻana me nā lāʻau hiamoe, analgesic a me nā hopena psychotropic,
• koki-kikina glaucoma,
• nā arrhythmias
• nā pilikia o ka hoʻokele intraventricular / atrioventricular,
• lolika lactose, hemahema o ka lactase a me ka malabsorption glucose-galactose,
• prostate hyperplasia me ka urinary retance,
• brieociaia
• hypokalemia
• mea e pā ai ka ʻōpū i loko o ke alo wai, pyloric stenosis,
• congenital elongated QT syndrome, me ka hoʻohui pū ʻana me nā lāʻau lapaʻau e alakaʻi ana i ka hoʻonui ʻana o ka manawa QT,
• hui pū me nā monoamine oxidase inhibitors, ʻo ia ka manawa o 14 mau lā ma mua o ka hoʻohana,
• makahiki i 18 makahiki
• lactation
• ka maʻi kūlohelohe o nā mea āpau o ka lāʻau lapaʻau.

E pili ana (me ke kau ʻana iā Amitriptyline Nycomed, e akahele ʻia a me ka mālama ʻana i nā mea lapaʻau).

• nā maʻi o ke koko a me ka ʻōnaehana cardiovascular, ka helu pū me ko angina pectoris a me ka hypertension arterial.
• ʻāhewa maka o ke kāwili o ka maka a me ke ʻōpala ākea i mua o ka maka,
• koki-kikina glaucoma,
• hoonui ae la ko lakou naau,
• mālama urinary
• ka huehuki,
• ʻo ka epilepsy (ka hoʻohana ʻia ʻana o Amitriptyline Nycomed e hiki i lalo ke kaohi i loko o ka paepae hōʻoia).
• kūlana kūlana
• pālahalaha
• palahalaka pila
• schizophrenia
• maʻi maʻi bipolar
• akea a he pāpaʻi hana,
• humuho waiwa,
• hui pū me nā lāʻau lapaʻau hiamoe a me nā hopena antipsychotic,
• hapai
• hiʻona kiʻekiʻe.

Nā ʻōkuhi no ka hoʻohana ʻana iā Amitriptyline Nycomed: ʻano a me ka helu ʻana

ʻO Amitriptyline nā papa papa ʻāpana 25 mg a i ʻole 10 mg e lawe ʻia ma ke ʻano, he mea maikaʻi loa ia ma hope o ka ʻaina. ʻAʻole pono nā papa Chew.

ʻO ka hoʻoponopono regimen maʻamau no nā maʻi maʻi ʻo: ma ka hoʻomaka ʻana o ka mālama ʻana - 25-50 mg ma 2 mau puʻupaʻa i hoʻokaʻawale ʻia, inā pono, e hoʻonui pinepine ʻia ka nui o ia lā i 200 mg, ʻo 6 ka lōʻihi o ka hoʻohana ʻana he 6 mau hola a ʻoi aku paha (i mea e pale ai).

ʻO ka inumele mua o kēlā me kēia lā ʻo Amitriptyline Nycomed no nā poʻe maʻi maʻi he 25-30 mg i ka 1 pākahi (ma ka pō). Inā pono, a hiki i ka hopena hopena, e hoʻonui ʻia ka momona i kēlā me kēia lā i 50-10 mg i kēlā me kēia lā. ʻO ka koho ʻana i kahi papa ʻalua e pono ai e nānā hou aku.

Me ka nele o ka ate, ua kuhikuhi ʻia ʻo Amitriptyline Nycomed i kahi hōʻemi helu ʻana.

I mea e nānā ʻole ai i ke ʻano o ka hila hōʻemi (i ke ʻano o ke poʻo o ke poʻo, ke ʻano hiamoe, hoʻomaha a me ke olakino maʻi maʻamau), e hoʻihoʻi hou i ka lāʻau. ʻAʻole nā ​​hōʻailona i ʻōlelo ʻia he hōʻailona no ke hilinaʻi o ka lāʻau lapaʻau.

Nā hopena hopena

ʻO kekahi o kēia mau hopena kūpono ʻole (ma ke ʻano, ka nui, ka hōʻeha, ka hōʻemi ʻana i ke kaomi sex a me ka span nānā, constipation) i lilo i hōʻailona o ke kaumaha, a hele lākou ma ke ʻano o ka hōʻeha ʻana o ke kaumaha.

ʻOi aku ma mua o 50% o nā maʻi i ka wā e hoʻohana ana iā Amitriptyline Nycomed e ulu a hoʻokahi a i ʻole nā ​​mea pili i lalo. Hiki i ka lāʻau lapaʻau ke alakaʻi i ka hoʻolālāʻana o nā hopena maikaʻiʻole, e like me ka mea e hōʻeha i nā antidepresi tricyclic.

Hiki i nā hopena ʻino (> 10% - pinepine pinepine,> 1% a me 0.1% a me 0,01% a

Ke keu

Kahi nā ʻōmaʻomaʻo o ka make nui i ka lāʻau e hoʻopau koke a hoʻomohala a hoʻomohala iki. I nā 2 mau hola mua, loaʻa i ka mea maʻi ka hoʻomau ʻana o ka psychomotor a i ʻole ka nalo, nā hallucinations, a me nā hōʻailona nō hoʻi ma muli o ka hana anticholinergic o amitriptyline (tachycardia, mau keokeo maloʻo, ʻūniha, mydriasis, noho hoʻomau i ka urinary, convulsions a me nā nāwaliwali o ka ʻōpū). A laila, hele aku ka hanu, ka pale paʻa ʻana o nā hana o ka pūnaehana o ka ʻōpū o ke kikowaena a me ka ʻike ʻole ʻana (a hiki i coma) i hiki mai.

ʻO nā mea maʻi ʻē aʻe he ʻano nui ka hopena i ka overdose, nā maʻi maʻi pediatric iʻike pinepine ʻia i nā hopena cardiotoxic a me ka hopu.

Mai ka ʻaoʻao o ka ʻōnaehana cardiovascular, he ʻano overdose o Amitriptyline Nycomed e hōʻike ʻia e flutter a me ventricular fibrillation, ventricular tachyarrhythmia. Ke nānā nei kēia mau hoʻololi hou i ka ECG: hoʻonui i ka paʻakikī QRS, inversion a i ʻole peau hoʻi i ka neʻe ʻana o ka T, ka lōʻihi o ka wā o ka PR, ke kaumaha o ka ST ST, hoʻonui i ka wā QT, a me nā ʻano like ʻole o ka poloka o ka hoʻokele intracardiac (a hiki i ka hopu ʻana i ke puʻuwai). Hiki i ka mea maʻi ke hoʻomohala i ka hypotension arterial, ka uha ʻole o ka naʻau, ka hypokalemia, ka pīhoihoi cardiogenic, ka metabolic acidosis, ke hopohopo aʻai, ataxia, nā hilahila a me nā hallucinations. Hiki paha i ke ʻano hiamoe.

Ma ka hihia o ka lawe ʻana iā Amitriptyline Nycomed i kahi laona ʻoi aku ka nui ma mua o ka palekana, a i ʻole ke kiko ʻana o nā hōʻailona o kahi hanana overdose, hoʻonāukiuki ʻia a me ke kākoʻo kākoʻo. Pono e hoʻokuʻu ʻia ka lāʻau lapaʻau. H holoi ʻia ka mea maʻi me ka ʻōpū a hāʻawi ʻia i ka charcoal hoʻōla ʻia (ʻoiai inā i hala kekahi manawa ma hope o ka lawe ʻana i ka amitriptyline). ʻO ka mea maʻi e nānā pono ʻia, me ka loaʻa o ke ʻano maikaʻi. He mea nui ia e hoʻomalu i ka paila o ka ea a me ka puʻuwai aloha, ka pae o ka noʻonoʻo a me ka nui o ke koko. Pono e nānā mau i ka ʻike pinepine ʻana o nā kahe a me nā electrolytes i ke koko. E hōʻoia i ka ea kūlohelohe maʻamau a, inā pono, hana i ka hoʻololi ʻana ponoʻī. Ke kiaʻi ʻia nei kahi ECG no 3-5 lā ma hope o ka overdose. ʻO ka arrhythmias Ventricular, ke ake ʻole o ka naʻau a me ka hoʻonui ʻana o ka paʻakikī QRS hiki ke hooki ʻia e ka neʻe ʻana i ka pH i ka ʻaoʻao alkaline (e ka hyperventilation a i ʻole kuhikuhi ʻana i ka hopena o ka sodium bicarbonate) a me ka hoʻolōʻihi wikiwiki i ka hopena o ka sodium chloride (100-200 mmol Na +). I nā mea maʻi me ka arrhythmias ventricular, hiki ke hoʻohana ʻia nā lāʻau antiarrhythmic kūlohelohe, no ka laʻana, ka hoʻokō ʻana i loko o 50-100 mg lidocaine (1-1.5 mg / kg), ukali ʻia e infusion me ka wikiwiki o 1-3 mg / min.

Inā pono, e kau i ka defibrillation a me ka cardioversion. Hoʻololi ʻia ka hoʻoponopono ʻana o ka hoʻopulapula kaila i ka hopena o ke kūlohelohe plasma, a ma nā pilikia koʻikoʻi, e ka dobutamine infusion (ʻo ka ʻōlelo mua ka 2-3 μg / kg / min, i ukali ʻia e kona piʻi, e pili ana i ka hopena i loaʻa). Hiki ke hoʻopau ʻia ka hoʻololi ʻana a me ka hoʻomāinoino ʻana me ka diazepam.

ʻO ke kūlana o ka metabolic acidosis ka mea maʻamau. ʻO nā Dialysis e wehe i ka amitriptyline mai ke koko he mea ole ia, no ka mea he haʻahaʻa ka hoʻouluulu ʻana o nā mea ʻole i loko o ke plasma.

I nā poʻe maʻi maʻi pākaha, hōʻemi a hōʻemi ikaika paha me ka lāʻau lapaʻau e ulu ma hope o ka lawe ʻana i ka 500 mg a i ʻole ʻoi aku o amitriptyline. Inā ʻoe e lawe 1000 mg a i ʻole, ʻoi aku kahi hopena momona.

Nā ʻōlelo kikoʻī

Ma mua o ka hoʻomaka ʻana i ka maʻi me Amitriptyline Nycomed, pono ia e hoʻokele i ke kahe o ke koko, e like me i ka poʻe me ka labile a hoʻohaʻahaʻa paha ke koko, e hōʻemi paha ia.

ʻAʻole kū aʻe nā maʻi i kahi ākea (e hāpai i kahi kūlana pololei) mai kahi noho hoʻopunipuni a noho ana paha. Ua hōʻike ʻia nā haʻawina (ʻo ka nui o ka noi ʻana nā maʻi he 50 mau makahiki a ʻoi aku) ua hōʻike ʻia ka hoʻohana ʻana o nā antidepresi tricyclic a me ka serotonin reuptake inhibitors e hoʻonui i ka hopena o ka hōʻeha o ka iwi, akā, ʻaʻole ka ʻike i ka hana o kēia hana.

I ka wā o ka mālama ʻana, ua ʻōlelo ʻia e kāohi i ka ʻano o ke koko o peripheral (ʻoi aku me ka hoʻomohala ʻana o ka tonsillitis, ka maʻi a i ʻole ka ʻano o nā hōʻailona like-like), a me ke ʻano lōʻihi - ke hana o ke ake a me ka pūnaehana ponoʻi. I nā maʻi me nā maʻi o ka ʻōnaehana cardiovascular a me nā poʻe maʻi maʻi, pono ia e hoʻomalu i ka ECG, ke koko a me ka puʻuwai puʻuwai.

Hoʻohana ʻia ka Amitriptyline me ka akahele i ka manawa like me ka poʻe inducers a i ʻole nā ​​mea pale o cytochrome P₄₅₀ CYPZA4.

I ka wā mālama, pono ia e kāpae i ka hoʻohana ʻana i nā mea inu wai.

Pono e hali wale ʻia ka hōʻemi ʻana i nā lāʻau, ʻoiai ke kali koke ʻana o ka komo ʻana, ʻoi aku hoʻi ma hope o ka wā lōʻihi, hiki ke alakaʻi i ka hoʻoiho ʻōmaʻomaʻo.

Hiki i ka M-anticholinergic hana i ka amitriptyline ke hoʻoulu i kahi hoʻouka o ka nui o ka paʻai intraocular. Hiki nō iā ia ke hōʻemi i ka lacrimation a hoʻonui i ka nui o ka pakano i ka waiʻai lacrimal, hiki iā ia ke alakaʻi i ka hōʻino i ke kaila o waho o ka korne i loko o nā poʻe e hoʻohana i nā lepa pilikino.

Ma ka hana lapaʻau, kahi hihia o ka make ma muli o ka arrhythmia e loaʻa ana i nā hola 56 ma hope o ka wehewehe ʻana o kahi overdose o ka lāʻau.

I ka poʻe maʻi me ka maʻi suicidal, e hoʻomau ka hana a me ka make i ka hoʻomaikaʻi ʻana a hiki i ka hoʻomaikaʻi nui ʻana i nā hōʻailona o ke kaumaha. Mai ka hoʻomaka ʻana o ka hopena thermulic o ka amitriptyline e hiki ke hele wale mai ma hope o 2 hebedoma kūmole o ka mālama ʻana, pono ka nānā ʻana i nā maʻi o ka mea e make ai a hiki i ka hoʻomaikaʻi ʻana o ko lākou kūlana. ʻO nā kānaka i hōʻike mua i ka noʻonoʻo suicidal a i ʻole nā ​​mea hoʻokaumaha suicidal, a me ka hoʻāʻo nō hoʻi e pepehi i mua o ka hoʻomaka ʻana i ka lāʻau a i ka wā e mālama ai, pono lākou i lalo o ka mālama kiaʻi. ʻO ka hoʻoili ʻia ʻana o nā lāʻau lapaʻau i kēlā mau maʻi e lawe wale ʻia e nā poʻe ʻokoʻa. Hiki iā Amitriptyline Nycomed (e like me nā antidepressants) iā ia iho ke hoʻonui i ka pinepine o ka suicides i nā poʻe maʻi ma lalo o ka 24 mau makahiki o laila, no laila, ma mua o ke kuhikuhi ʻana i ka lāʻau i nā mea maʻi ma lalo o ka 24 mau makahiki o ia, pono e hoʻoholo i ke ʻano o ka pōmaikaʻi o kona hoʻohana a me ka hopena o ka make.

I ka poʻe me ka maʻi manic-depressive, hiki i ka amitriptyline ke hōʻeha i kahi manic. Ma kahi o nā hōʻailona manic, pono e hoʻoneʻe i ka lāʻau lapaʻau.

Hiki i ka poʻe maʻi e loaʻa i ka antidepresi tetracyclic i ka wā like me ka nui a kūloko kūloko paha e hoʻonui i ka hopena o ke kahe o ke koko a me ka hoʻomohala ʻana i ka arrhythmias. ʻO ia ke kumu e hāpai ʻia e kāpae i ka lāʻau lapaʻau ma mua o ka hana ʻoi ʻana i hoʻolālā ʻia. Ma ka hihia o nā wawaʻi o ka hōʻemi ʻana, pono e hoʻomaopopo ʻia ka anesthesiologist e pili ana i ka lawe ʻana i ka amitriptyline.

Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka hana o ka insulin a hoʻololi i ke kaila o ka glucose i ke koko ma hope o ka ʻai ʻana. I nā maʻi me ka maʻi mellitus, pono ke hoʻoponopono ʻia i ka lāʻau. Hiki i ke kūlana o ke kaumaha i loko ona ke hoʻololi i ka metabolism glucose.

ʻO ka poʻe e lawe ana iā Amitriptyline Nycomed e hōʻike i kā lākou dentist e pili ana i ka lawe ʻana i ka lāʻau.Hiki i ka waha momona ke hōʻeha i nā maʻi, nā hoʻololi i ka mucosa waha, nā kahu niho o ka niho, a me ka hōʻā ʻana i ka waha. Hoʻomaopopo ʻia ka poʻe maʻi e kipa pinepine i ka dentist.

ʻŌpū a me ka lactation

Hoʻohui ʻia ka ʻike lāʻau lapaʻau me Amitriptyline Nycomed i nā wahine hāpai. ʻAʻole paʻa i ka palekana o ka amitriptyline no ka pūpū.

ʻAʻole kuhikuhi ʻia ka lāʻau lapaʻau e kuhikuhi ʻia i ka wā hāpai, ʻoi aku hoʻi i nā mea hoʻomaʻi o I a me III, koe i nā hihia i ʻoi aku ka nui o ka pōmaikaʻi i ka makuahine ma mua o ka hiki i ka pūpū. Pono e lūlū i kahi wahine hāpai i kahi koʻikoʻi koʻikoʻi o ka hopena o ka lāʻau lapaʻau ma luna o kahi ulu hāpai ʻana, ka mea nui loa i ka trimester III. ʻO nā dosis nui o nā antidepresan tricyclic i hoʻohana i ke kolu ʻoi aku hiki ke alakaʻi i nā maʻi neurological i nā keiki hou. Ua hōʻike ʻia nā hihia o ka hiamoe a me nā pēpē i lawe nā makuahine i ka nortriptyline i ka wā hapai, a me nā hihia o ka mālama ʻana i ka paʻakai ma nā keiki hou.

I nā noiʻi holoholona, ​​ua ʻike ʻia nā hopena o ka lāʻau ma hope o ka lawe ʻana i nā papa i kekahi manawa i ʻoi aku i ka nui o ka wai lapaʻau maʻamau no nā kānaka.

Hoʻopili ʻia ʻo Amitriptyline i ka wā lactation, no laila ʻo ka hōʻuluʻulu ʻana e pono ai e hoʻokuʻu i ka wā o ka mālama ʻana me ka lāʻau lapaʻau.

Hoʻohui nūhou

Amitriptyline Nycomed potentiates ka pale ʻana o ka nūnaʻenehana kūloko ma waena o nā lāʻau lapaʻau e hiki mai ana: narcotic a Central analgesics, antipsychotics, anticonvulsants, hypnotics and sedatives, alkohol, and anesthetics general.

ʻO nā lāʻau hōʻalo i ka isoenzyme CYP2D6 (ʻo ka isoenzyme nui i loaʻa ai nā antidepresants tricyclic) hiki ke hoʻokaʻawale i ka metabolism amitriptyline a hoʻonui i kona kaila plasma. Kēia mau lāʻau like me: antipsychotics, nā lāʻau antiarrhythmic hope loa (propafenone, procainamide, esmolol, amiodarone, phenytoin), serotonin reuptake inhibitors (me ka hoʻokaʻawale ʻana i citalopram, kahi mea pale palupalu), P-blockers.

Hoʻopili ʻia ʻo Amitriptyline Nycomed e hoʻohana pū me ka neʻe ʻana o MAO, no ka mea, ʻo ia hui pū ʻana e alakaʻi ai i ka hanana serotonin syndrome, ka mea e pili ana i ka pīhoihoi, myoclonus, ʻehaʻeha me ka noʻonoʻo blurred a me kahi coma. Hiki ke hoʻomaka ka lāʻau lapaʻau e hoʻohana i nā hebedoma 2 ma hope o ka pau ʻana o ka hōʻola ʻia me nā mea pale ʻole MAO nonvertises, non-selective MAO inhibitors a me 1 lā ma hope o ka haʻalele ʻana o ka moclobemide (reversible MAO inhibitor). Ma ka huli ʻana, hiki i ka mālama ʻana me MAO inhibitors ke hoʻomaka i mua ma mua o nā hebedoma ma hope o ka hiki ʻana ke hoʻopau ʻia iā Amitriptyline Nycomed. I nā pilikia mua a me ka lua, ʻo ka ʻoihana me ka MAO inhibitors a me amitriptyline e hoʻomaka me nā dosis liʻiliʻi, a laila e hoʻonui pinepine.

ʻAʻole kuhikuhi ʻia ka lāʻau lapaʻau no ka hoʻohana pinepine ʻana i nā lāʻau lapaʻau penei:

• i hoʻohui ʻia i ka maʻi o nā lāʻau lapaʻau ma ka ʻōnaehana o ka cardiovascular, a laila.
• nā mea hana blocker adrenergic (methyldopa, clonidine): nā nāwaliwali o ka hopena antihypertensive o nā mea hoʻoponopono block adrenergic hiki
• m-anticholinergics (derivatives phenothiazine, atropine, antiparkinsonian drug, biperiden, H blockers₁-nistamine receptors): hiki i ka amitriptyline ke hoʻonui i ka hopena o kēia mau lāʻau ma ka palupalu, kōpeka, ka kino o ka ʻike a me ke ʻano kikowaena kūloko, pono e ʻalo ʻia ka hoʻohana ʻana ma muli o ka loaʻa ʻana o ka piʻi ikaika o ka mahana a me ka pōkī palu.
• nā lālani e hoʻolōʻihi nei i ka manawa QT (nā lāʻau antiarrhythmic, kekahi mau antipsychotics, H blockers₁histamine receptors, anesthetics, sotalol, chloral hydrate): ʻo ka ulu ʻana o ka hoʻoulu ʻana i ka arrhythmias ventricular,
• lithium paʻakai: hiki i ka mea hiki ke hoʻonui i ka hoʻonaninā o ka lithium, i hōʻike ʻia e nā mākui tonic-clonic, nā puhaka, ka noʻonoʻo ʻana o ka noʻonoʻo, nāhelehele, ka pilikia i ka hoʻomanaʻo ʻana a me ka malignant antipsychotic syndrome,
• antifungal aihue (terbinafine, fluconazole): ka nui o ka serum o ka amitriptyline e hoʻonui ai a me ka hoʻopā kino o ka lāʻau pili me ka piʻi.

Hoʻohana ʻia ʻo Amitriptyline Nycomed me ka makaʻala me ka wā like me nā lāʻau lapaʻau penei:

• nā hua lāʻau e hoʻoneʻe ana i ka pūnaehana neʻe i ka waena (ikaika analgesics, sedatives a me hypnotics, ethanol a me nā huaʻōlelo e pili ana i ka ethanol): hiki ke hoʻonui i ka hana o nā hana o ka pūnaehana o ka pūnaehana,
• nā kinuhi o nā mikrosomal ate enzymes (carbamazepine, rifampicin): hoʻonui i ka metabolism amitriptyline a e emi paha ka hoʻoliʻiliʻi ʻana o ka plasma, ke alakaʻi nei i kahi nāwaliwali o ka hopena antidepressant,
• antipsychotics: hiki i ka hoʻokaʻawaleʻana o nā hana metabolism ka mea hiki ke hōʻemi i ka paepae hoʻokipa a alakaʻi i ka hoʻomohala ʻana o ka make (i kekahi manawa ke hoʻoponopono ʻia o nā ʻano antipsychotics a me amitriptyline).
• lohi aku nā konohiki palema lōlō, methylphenidate, cimetidine: hoʻonui i ka plasma o ka amitriptyline e hoʻonui a hoʻonui ʻia kāna mau maʻi,
• nā lāʻau hiamoe a me nā antipsychotics: ʻo ka hoʻohana ʻana i ka amitriptyline, nā lāʻau hiamoe, a me nā antipsychotics ʻaʻole i kuhikuhi ʻia (inā pono, pono e pili pono ka hoʻohana ʻana o kēia hoʻohui).
• valproic acid: hoʻonui konsentrate amitriptyline a me nortriptyline (e koi paha ka hoemi ʻana o ka nui o ka lāʻau),
• sucralfate: nāwaliwali loa o ka hoʻopili ʻana o ka amitriptyline a ua hōʻemi ʻia kona hopena antidepressant,
• phenytoin: ua pā ka phenytoin metabolism a hoʻonui ʻia kona ʻano (ataxia, tremor, nystagmus a me ka hyperreflexia).
• hoʻomākaukau o ka perforatum hypericum: hoʻohuihui ka metabolism o ka amitriptyline i ka ate a hoʻoneʻe ʻia kona kiʻekiʻe ma ka plasma (e ʻae ʻia ka hoʻoponopono ʻana o ka amitriptyline).

Nā Papa inoa ʻo Amitriptyline Nycomed ʻo Amitriptyline, Amitriptyline Zentiva, Amitriptyline Grindeks, Vero-Amitriptyline, Amitriptyline-Ferein, Saroten retard, etc.

Nā palapala ʻano:

pani ʻ -lelo ʻlelo

Hoʻokahi pū ʻia nā papa kiʻi 10-pile i loaʻa:
mea ikaika: hyitrchloride 11.3 mg ma amitriptyline 10 mg,
nā mea hoʻowalewale: magnesium stearate 0.25 mg, povidone 0.83 mg, talc 2.25 mg, microcrystalline cellulose 9.5 mg, huaʻai 28 28 mg mg, lactose monohala 27,0 mg,
ʻili: propylene glycol 0.2 mg, titanium dioxide 0.8 mg, hypromellose 1,2 mg, talc 0.8 mg.
Hoʻokahi i ka papa papaʻa 25 mau ʻāpana.
mea ikaika: ʻO ka hānai amitriptyline 28.3 mg ma amitriptyline 25 mg,
nā mea hoʻowalewale: magnesium stearate 0.5 mg, povidone 0.6 mg, talc 4,5 mg, cellulose microcrystalline 18.0 mg, huaʻai māhu 38.0 mg, mole lactose 40.2 mg,
ʻili: propylene glycol 0.3 mg, titanium dioxide 0.9 mg, hypromellose 1,4 mg, talc 0.9 mg.

ʻO keʻano

ʻO nā papa, ke keʻokeʻo i kālai ʻia, ʻoniʻoni, biconvex.

Hōʻikeʻike e pili ana iā Amitriptyline Nycomed

He loiloi maikaʻi ka hopena a me ka maikaʻi ʻole. Ke hōʻike ʻia nei no ka hoʻohana ʻana e nā 75% o nā mea hoʻohana. ʻO nā pono nui o kahi antidepressant: ka hana, ka hoʻokaʻawale maikaʻi, ke kumu kūʻai haʻahaʻa. Hoʻōloe maikaʻi ka lāʻau lapaʻau i ka hopohopo, kōkua i ka hōʻehaʻeha o ka maʻi, nā hana a me ka hōʻeha ʻana i ka hōʻeha ʻana, hōʻoluʻolu, hoʻomaha i ka ʻōnaehana o ka nūnū, e hōʻoluʻolu i ke kaumaha a me ka neurosis.

ʻO nā nāʻino ʻole o ka Amitriptyline Nycomed, e like me nā mea maʻi, ʻo nā hopena ʻokoʻa (ʻoi aku ka nui o ka makemake a me ka nui o ka momona, ka waha maloʻo, ʻeha o ke alapine, kaomi ʻana o ke koko, ke kuʻalo, a me nā mea hou aku). Hoʻopiʻi kekahi poʻe hoʻohana e pili ana i ka nele o ka pono o ka hāmeʻa. He nui nā contraindications i ka lāʻau lapaʻau, ʻae ʻia ma ka ʻai wale ʻana, hiki nō ke hoʻohui, no laila, koi ʻia kahi hoʻokaʻawale - ʻo ia nā pōʻino nui i ʻōlelo ʻia i nā loiloi.

ʻO nā waiwai Pharmacological

Amitriptyline he antidepressant tricyclic mai ka pūʻulu o nā mono-non-selective monoamine reuptake inhibitors. Loaʻa ia ka hopena thymoanaleptic a me ka sedative.
Lapaʻau lāʻau
Hoʻopili ʻia ka hana o ka hana antidepressant o amitriptyline i ka hoʻonui ʻia ʻana o ka ʻike o norepinephrine a me serotonin i loko o ka synaptic cleft i ka Central nerve system (CNS).
ʻO ka hōʻiliʻili ʻana o kēia mau neurotransmitters e hele mai ma muli o ke kaomi ʻana o ko lākou hopu hou ʻia e nā membranes o nā neurons presynaptic.
ʻO Amitriptyline kahi mea huna o Ml a me M2 muscarinic cholinergic receptor, H1 histamine receptors a me11 adrenergic receptor. E like me ka mea i kapa ʻia ʻo ka monoamine hypothesis, aia kahi pilina ma waena o ke kani a me ka hana o nā neurotransmitters ma nā synapses o ka lolo.
Ke hōʻike nei ka hopena ma waena o ka neʻe ʻana o ka amitriptyline i loko o ke kaila koko a me ka hopena hopena ʻole, ʻaʻole hōʻike ʻia, akā ʻo ka hopena lapaʻau maikaʻi loa, ʻoiai, ua hoʻokō ʻia i nā mea paʻa i loko o ka laulā o 100-260 μg / L.
Loaʻa ka maʻi palupalu o nā maʻi kaumaha ma hope ma hope o ka loaʻa ʻana o ka umikine plasma kūlā, ma hope o ka 2-6 mau pule o ka mālama ʻana.
Eia kekahi, ʻo ka amitriptyline i kahi hopena like-quinidine ma ka hohonu o ka naʻau.
Lapaʻau lāʻau
Kapehu
Ma hope o ka lawelawe waha, ua nui ka piha ʻana me ka amitriptyline mai ka ʻōpū o ka gastrointestinal. Loaʻa ka ʻike kiʻekiʻe loa i ka plasma koko (Cmax) i loko o nā hola 2-6 ma hope o ka hoʻokele ʻana.
Kahele
ʻO ke kaanepau o amitriptyline i loko o ke koko koko o nā mea maʻi like ʻole e loli ʻokoʻa.
ʻO ka bioavailability o amitriptyline e like me 50%. ʻO Amitriptyline i kahi ākea nui (95%) e hoʻopaʻa ai i nā protein plasma. ʻO ka manawa e hiki ai i ka lōʻihi loa o ka mālama ʻana (TCmax) ma hope o ka lawelawe waha ʻana he 4 mau hola, a ʻo ka neʻe ʻana o ke kūkaʻe kaulike ma kahi o hoʻokahi pule ma hope o ka hoʻomaka ʻana o ka mālama ʻana. ʻO ka nui o ka hoʻolaha e like me 1085 l / kg. ʻO nā amitriptyline a me nortriptyline e hele i ka plasenta a hoʻopili ʻia i loko o ka waiū umauma.
Hāpai
Hoʻomili ʻia ʻo Amitriptyline i loko o ka ate a ua nui ka nui (e pili ana iā 50%) i ka manawa mua e hele ai ma loko o ka ate. I ka manawa like, loaʻa iā amitriptyline N-demethylation e ka cytochrome P450 me ka hoʻokumuʻana o ka metabolite hoʻoikaika - nortriptyline. ʻO nā amitriptyline a me ka nortriptyline, he hydroxylated wale i ka nui. ʻO Nitroxy a me 10-hydroxymetabolite amitriptyline a me 10-hydroxynortriptyline e hoʻohana pū ana. Hoʻokomo ʻia nā amitriptyline a me nortriptyline i ka acid glucuronic, a ʻaʻole paʻa kēia mau conjugates.
ʻO ka mea nui e hoʻoholo ai i ka hoʻomaʻemaʻe kino, a, ma muli, ʻo ke kikoo o ka plasma koko, ʻo ia hoʻi ka helu o ka hydroxylation. Ma kahi'āpana liʻiliʻi o nā kānaka, ua ʻike pono genetically paʻa i ka hydroxylation. I ka poʻe maʻi me ka pīhoihoi hana ʻino, hoʻonui ʻia ka hapalua o ka amitriptyline a me nortriptyline i loko o ke koko koko.
Leʻaleʻa
ʻO ka hapalua-ola (T1 / 2) mai i ke koko koko he 9-46 mau hola no ka amitriptyline a me nā hola 18-95 no nortriptyline.
Hoʻomau ʻia ʻo Amitriptyline e nā keiki a me ka palu ma loko o ke ʻano o nā metabolites. Hoʻokahi wale wahi hapa o ka amitriptyline i kāhea ʻia ma o nā keiki i loli ʻole. I nā mea maʻi me ka hana renal maʻi ʻole, ua lohi ka excretion amitriptyline me nortriptyline metabolites, ʻoiai ʻaʻole i loli ka metabolism. Ma muli o kāna hui pū me nā protein koko, ʻaʻole i hoʻoneʻe ʻia ka amitriptyline mai ka lolo koko me ka dialysis.

Nā hōʻailona no ka hoʻohana ʻana

• autism
• hypochondria
• manaʻo ʻino
• schizophrenic psychosis,
• bulolia nervosa
• mea hiamoe,
• nā ʻeha hōʻeha o nā ʻehaʻeha
• maʻi maʻi ulia maʻi
• migraine prophylaxis.

Ma waena o ka papa holoʻokoʻa o nā maʻi kūlohelohe koʻikoʻi, pono hoʻi e hoʻomaopopo i ka lāʻau lapaʻau i kuhikuhi ʻia e nā poʻe loea e like me nā poʻe maʻi maʻi maʻi e hōʻemi ai i ka ʻeha. I ka hihia o ka hōʻino o ka kūlana a me ke ʻano, hoʻonui nui ka hopohopo, nā pilikia hiamoe a hoʻohemo ʻole i ke kaumaha, kōkua ka hōʻola i ka 100%, pono ia e hoʻomanaʻo wale i ka hoʻomaka koke ʻana e hana koke.

ʻO nā kumukūʻai no ka amitriptyline kacomed i loko o nā lāʻau lapaʻau ma Moscow

Hōʻike nā kauka e pili ana i nā kauka e pili ana i ka amitriptyline nycomed

ʻO ka ʻike ma ka hoʻohana ʻana iā Amitriptyline i mea hoʻohana hou aku i ka mālama ʻana i ka ʻeha vertebrogenic ua alakaʻi i ka hopena e pili ana i ka hopena o kēia lāʻau ma nā maʻi me ka maʻi hōʻeha a me ka maʻi nui. Ua loaʻa ka hopena sedative i ke ʻano o ka hiamoe i ka wā ahiahi o ka hana ʻana i ka lāʻau.

Amitriptyline. ʻO kēia ka mua. A ʻo ka lua, makemake ʻia ia mai ka ʻanekauaka loa ʻāpono "mai nā mea amitriptyline ʻē aʻe i loaʻa ma ka pae Kemerovo. He wahi nō ia o 10 mg, kahi mea kūpono loa i ka wā i kuhikuhi ʻia i nā poʻe maʻi me ka hiki ʻana i ka autonomic instability a (a i ʻole) me ka negativity e pili ana i ka "antidepressants".

ʻO nā pilikia maʻamau no ka amitriptyline: cardiotoxicity, hoʻonui i nā kiʻekiʻe o ka prolactin i loko o ke koko, hoʻonui nui i ke kino, hiki ke hoʻokumu ʻia ka cystitis.

ʻO ka amitriptyline maikaʻi loa i ka mākeke o ka māhele Kemerovo.

Hoʻomaʻama pinepine nā maka a me ka hopena o ka cholinergic: kaumaha i ke poʻo, mālama urinary, constipation.

ʻO kekahi o nā antidepresi ikaika loa, me nā hopena anti-anxiety hopohopo. Ka hopena i nā episode depressive koʻikoʻi endogenous, hoʻomau i ke kaumaha, ka huhū a me ka naʻau atypical. Hiki ke hoʻohana no nā ʻano kāwili e hopohopo nei, me ka insomnia.

ʻO nā loiloi maʻi maʻi e pili ana i ka amitriptyline Nycomed

ʻAʻole au i makemake i kekahi ʻike i kaʻu i ʻike ai no kēia lāʻau lapaʻau weliweli! ʻ saidlelo ke kauka e hōʻoluʻolu wau, akā ʻaʻole e ao i ka mea e lilo wau i mea kanu. Kolohe loa kēia! ʻAʻole he mea ʻole o nā manaʻo suicidal i loaʻa iaʻu, ʻo Amitriptyline ka mea e hōʻino ai. Horo!

Ua kuhikuhi mai kahi neurologist ʻole iaʻu ʻo Amitriptyline e hōʻemi i ka hoʻoulu ʻana o ka migraine. Loaʻa wale ʻia kēia lāʻau lapaʻau i ka lāʻau lapaʻau, aʻu i makemake ʻole ʻole ai, no ka mea ke puka o nā pills, pono ʻoe e hele i ka haukapila, kū ma ka laina no ka manawa pōkole, a laila hiki wale nō ʻoe ke hele i ka lāʻau lapaʻau nona. Akā ʻo ka hapalua wale nō o ka pilikia, lawe ʻia no nā malama ʻeono, e like me ke kauka ʻana a ke kauka, ʻaʻohe hopena pili ʻole, ʻaʻohe hopena hou aʻe, ʻaʻole hoʻi lākou hoʻomaka. Loaʻa paha ia i nā maʻi ʻē aʻe, akā ʻaʻole paha i kaʻu hihia.

Ma 2017, ua loaʻa wau i kahi kūlana ʻē loa, like me ka puʻuwai puʻuwai, akā i ka huli ʻana i ka wā hope - he hōʻeha panikō. Ua lawe ʻia au i ka haukapila, ma ka neurology, ma laila ke kauka kauka mai iaʻu i kēia mau poho, ʻo ka make mua ka hapalua o ka pailua i ka pō a laila piʻi lohi ʻia, no laila lawe wau iā lākou e like me ka kumumeaʻo 0.5 0.5 1 (ke kakahiaka, kakahiaka a me ke ahiahi ), i ka mua ma laila ua loaʻa ka hiamoe, a hiamoe maikaʻi a maikaʻi hoʻi, hiamoe me ka bang! Ua ʻike ʻia ka hopena i loko o nā pule he ʻelua, i ka manawa i hopu ai au iaʻu iho i ke ʻano o koʻu ʻano nui a ʻaʻole ia i hana! Ua hauʻoli wau i nā ʻano nīhou e like me ka lā o ka lā, ka ʻūhā o nā lau, nā mele i hoʻohemo ʻole i nā manaʻo ikaika loa i mua o kēia manawa, ua hoʻolilo ʻia kēia manawa i nā manaʻo hauʻoli nui. A, ʻae, ua loaʻa hoʻi iaʻu nā moemoeā kūlike. Ma hope mai, ua hōʻemi ʻia ka ʻona, kōkua maikaʻi ke lāʻau iaʻu, ua holo maikaʻi ʻo ia.Akā pono ʻoe e hoʻolohe i kou ʻano, no ka mea, he ʻuhane ia.

I loko o koʻu ola ua loaʻa iaʻu kahi maʻi e like me ka kaumaha. ʻIke wau i kahi mea maʻi noʻonoʻo naʻauao, a kākau ʻo ia iaʻu Amitriptyline. Maʻa ka maikaʻi o ka lāʻau lapaʻau, hakakā me ka hopohopo, hoʻoneʻe i ka insomnia. Ua kuhikuhi ʻia maʻu i ka waihona o 20 mg i ka pō a me 10 mg i ke ahiahi, a liuliu noho wale nō wau ma ka pōkiʻi pō. ʻO ka lāʻau, ʻoiai ke kahiko, akā kope me ka hana. Nui ka poʻe e makaʻu nei i nā hopena ʻokoʻa, ʻaʻole wau iā lākou, ke hiamoe wale nei, akā aia ma koʻu lima, no ka No ka manawa lōʻihi ua pilikia mai ka ʻūhā.

ʻO "Amitriptyline" i kuhikuhi ʻia e kahi mea lapaʻau, hopohopo e pili ana i ka hopohopo. He maikaʻi ka lāʻau lapaʻau, inā i kuhikuhi pono ʻia he mea kōkua maoli ia. He mea nui e inu i ka pōkole hope a hiki i 20.00 mau hola, inā ʻaʻole ia e hoʻohauʻoli i ka ʻōnaehana pīhoihoi, pilikia. Inā hele ka luhiluhi, tachycardia - pono e hōʻemi ʻia ka dosage. ʻO 1/4 o 10 mg 2 mau manawa i ka lā a me 1/2 o 10 mg i ka pō ua hāʻawi i kahi hopena mau loa. ʻAʻohe hopena hopena inā ʻaʻole ka tachycardia.

Lapaʻau

ʻO Antidepressant mai ka pūʻulu o nā pūnaehana tricyclic, kahi mea o ka dibenzocycloheptadine.

Hoʻopili ʻia ka hana o ka hana antidepressant me ka hoʻonui i ka neʻe ʻana o ka norepinephrine i loko o nā synapses a me / a i ʻole serotonin i loko o ka pūnaehana ninaninau ma muli o ke kaohi ʻia ʻana o ka huli ʻana o ka neuronal reversant o kēia mau ʻōlelo. Me ka hoʻohana ʻana i ka manawa lōʻihi, e hōʻemi ana i ka hana hana o nā ʻenekele β-adrenergic a me nā ʻaluna serotonin i loko o ka lolo, hana maʻamau i ka hoʻoili ʻana o ka adrenergic a me serotonergic, a e hoʻihoʻi i ke kaulike o kēia mau ʻōnaehana, ka mea i haki ʻia ma nā wahi kaumaha. I nā hopohopo-kaumaha kaumaha, e hōʻemi ana i ka hopohopo, ke kuuhū a me nā hōʻailona kaumaha.

He mau ʻāpana analgesic kekahi, i manaʻoʻiʻo ʻia ma muli o nā loli i ke kaohi ʻana o nā monoamines i loko o ka papa launa ma waena o ka ʻili, a me ka serotonin, a me ka hopena o nā pūnaehana opogenid endogenous.

Ua hoʻolaha ia he peripheral a me ka hopena anticholinergic hopena, ma muli o ka pilina kiʻekiʻe no ka m-cholinergic receptors, kahi hopena sedative e pili ana i ka pilina me histamine H₁-receptors, a me ka hana ʻohiʻā alpha-adrenergic.

Loaʻa iā ia kahi hopena antiulcer, ke kahe o ka mea ma muli o ka hiki ke kahaki i ka histamine H₂-receptors i loko o nā selela parietal o ka ʻōpū, a loaʻa pū kekahi hopena sedative a me m-anticholinergic (inā i ka ulia peptic o ka ʻōpū a me ka duodenum, e hoʻemi ana i ka ʻeha, a e hoʻolōʻihi i ka hoʻōla ʻana i nā ʻōpio).

Pono ke ʻano o ka moe moe ma muli o ka hana anticholinergic, ke alakaʻi nei i ka hoʻonui ʻana o ka hiki ʻana o ka papa ʻaina ke kūlaʻi, hoʻopuka pololei ana β-adrenergic, hana o ka agonist α-adrenergic, i hoʻopili ʻia e ka piʻi ʻana o ka leo sphincter a me ka poloka waena o ka serotonin uptake.

ʻO ka weheʻana o ka hana therapeutic i ka bulimia nervosa ʻaʻole i hoʻokumu ʻia (pono paha e like me ia i ka minamina). Hōʻike ʻia ka ʻike maʻalahi o ka amitriptyline ma bulimia i nā mea maʻi me ka ʻole o ke kaumaha a me ka neʻe ʻana, a me ka ʻike ʻana i ka emi ʻana o ka bulimia e ʻike ʻole me ka nāwaliwali ʻole o ka pohō kaumaha.

Ke hana nei i ka anesthesia ākea, e hoʻohaʻahaʻa ia i ke koko a me ke ʻano wela o ke kino. ʻAʻole ke keʻakeʻa iā MAO.

Hoʻokomo ka hopena antidepressant i loko o nā hebedoma 2-3 ma hope o ka hoʻomaka ʻana o ka hoʻohana.

Hoʻohui

Me ka hoʻohana pū ʻana me nā lāʻau lapaʻau ka hopena i ka hopena hoʻopihapiha ma ka pūnaehana nīnū, ʻo ka hoʻonui nui ʻana i ka hopena o ka inhibitor ma ka ʻōpū o ke kikowaena kūwili, ka hopena antihypertensive, a me ke kaumaha o ka hanu.

I ka hoʻohana pū ʻana me nā lāʻau me nā hana anticholinergic, hiki i ka nui aʻe o nā hopena anticholinergic.

Me ka hoʻohana like ʻana, hiki i ka hoʻonui ʻia ʻana o nā hopena o nā aila sympathomimetic ma ke ʻano o ka cardiovascular a hoʻonui i ke pilikia o ka hoʻomohala ʻana i ka arrhythmias cardiac, tachycardia, a me ka hypertension arterial koʻikoʻi.

Me ka hoʻohana like ʻana me nā lāʻau antipsychotic (antipsychotics), ʻano hui ka metabolism, ʻoiai e hoʻemi ana ka paepae.

Me ka hana like me nā hui antihypertensive (me ka hoʻoleʻa clonidine, guanethidine a me nā mea waiwai o lākou) hiki ke hoʻonui i ka hopena antihypertensive a me ka hopena o ka hoʻomohala ʻana i ka hypthension orthostatic.

Me ka hoʻohana like ʻana me ka MAO inhibitors, hiki i ka hiki ke hoʻomohala ʻia ka pilikia hypertensive, me ka clonidine, guanethidine - hiki ke loaʻa i ka hopena hypotensive o clonidine a i ʻole guanethidine, me ka barbiturates, carbamazepine - hiki ke hōʻemi i ka hopena o ka amitriptyline ma muli o ka hoʻonui ʻana i ka metabolism.

ʻO kahi hihia o ka hoʻouluʻana o ka serotonin syndrome me ka hoʻohana pū ʻana me ka sertraline i wehewehe ʻia.

Me ka hoʻohana pū ʻana me ka sucralfate, ke emi nei ka ʻike ʻana i ka amitriptyline, me ka fluvoxamine, ka ʻike ʻana o ka amitriptyline i loko o ke koko a me ka hopena o nā hopena kūlohelohe e hoʻonui, me fluoxetine, ka paʻa ʻana o ka amitriptyline i loko o ke kaila toto a me ka hopena o nā mea i hoʻoneʻeneʻe ʻia ma muli o ka pale ʻana o ka CyP2D6 hiki i ka mana o ka flenxzyine, me ka fluoxetine. metabolism amitriptyline, me cimetidine - hiki i ka hoʻolōʻihi i ka metabolism amitriptyline, hoʻonui i kona kaila i ke koko koko a hoʻomohala i ka t ksicheskih 'ole.

Me ka hoʻohana like ʻana me ka ethanol, hoʻonui ʻia ka hopena o ka ethanol, ʻo ia hoʻi i nā lā mua o ka lā o ka maʻi.

ʻŌpū a me ka lactation

ʻAʻole pono ke hoʻohana ʻia ʻo Amitriptyline i ka wā hapai, maʻa mau ke koʻikoʻi ʻo I a me III, koe i nā hihia pōpoki. ʻO ka lawa ʻana a me ke aʻo ʻana i nā haʻawina ʻoihana palekana no ka palekana o ka amitriptyline i ka wā hāpai ʻana ʻaʻole i mālama ʻia.

ʻO ka wehe ʻana i ka amitriptyline e hoʻopau iki i ka liʻiliʻi ma 7 mau hebedoma ma mua o ka hānau ʻana i manaʻo ʻia e pale aku ai i ka hoʻomōhala hānai i ka maʻi hānau.

I nā hoʻokolohua hoʻokolohua, loaʻa i ka amitriptyline kahi hopena teratogenic.

Contraindicated i ka wā lactation. Hoʻopili ʻia ia i ka umauma umauma a ma muli o ka lūlū ʻana i nā pēpē.

Nā leo a me ke kumukūʻai

"Amitriptyline Nycomed" (25 mg) i nā papa i loko o nā lāʻau lapaʻau kikowaena e pili ana i ka 50-70 rubles i kēlā me kēia pā. Eia kekahi, loaʻa ka lāʻau lapaʻau i ke ala o nā hopena no ka hoʻonā a me ka infusion.

Hoʻohālikelike ʻia ʻo Amitriptyline (25 mg) ma nā palapala papa e nā hui he nui ma lalo o ka inoa like.

No laila, nā hoʻohālikelike o ka lāʻau mai ke kumukūʻai lapaʻau "Nycomed" he mau lāʻau mai nā mea hana:

Eia kekahi, aia kekahi loulou me ka ʻenehana o nā huahana i hana ʻia a me nā papa i kapa ʻia "VERO-AMITRIPTILINE", i hoʻopuka ʻia e nā ʻoihana hoʻoliʻāina ʻokoʻa.

Kāleka e hoʻohana

Eia kekahi e hoʻopili i nā mea ʻole o kēlā me kēia o nā mea a pau, pono ʻia e hoʻohana ʻia:

• i ka wā gestation a me lactation,
• mau keiki malalo o na makahiki ehiku
• i ka wā o ka hoʻihoʻi ʻana ma hope o ka hoʻoulu ʻana i ka puʻuwai,
• me ka aniani-palena pani glaucoma,
• me ka maʻi puʻuwai koʻikoʻi,

Hoʻoleʻo ia i ka lawe ʻana i ka "Amitriptyline", kahi ona wai, ka psychotropic, analgesic a me nā mea hiamoe hiamoe.

Nā hopena hopena

No ka "Amitriptyline Nycomed" (25 mg), ua ho'ākāka ʻia nā ʻōkuhi no ka hoʻohana ʻana me ka antidepressant ikaika loa, ʻo ka papa inoa o nā hopena e hiki ʻole ai e hopena. ʻOiai me kēia, e like me nā loiloi, ma ka hapanui o nā maʻi ʻaʻole lākou i ʻike ākea a i ʻole he mau maʻi haki wale paha i ʻike ʻia i nā lā mua ma hope o ka hoʻomaka ʻana o ka lapaʻau.

No laila, hiki i ka lāʻau lapaʻau ke hōʻeha i nā pilikia mai:

• ʻōnaehana ʻōnaehana
• kalepa
• cardiovascular
• endocrine
• hematopoietic.

Pēlā nō hoʻi, "Amitriptyline", i ka ʻōlelo aʻo i ka papa inoa piha o nā hopena ʻona, hiki ke hōʻeha i nā ʻano maʻi like ʻole i ka ʻili i ke ʻano o ka rashes, ka ʻāʻī a i ʻole ka ʻeha. Eia kekahi, i kekahi mau mea maʻi, nalo ka lauoho, ua hūnā ʻia nā nīnū lymph a me nā tinnitus i nā wā aʻo.

I waena o nā hopena maʻamau, hiki i nā mea maʻi ke hoʻokaʻawale i nā hōʻike pilikino e pili ana i ka hana anticholinergic. Hoʻopili kēia me ka mahina wale, ka maloʻo, ka tachycardia, hilahila, i nā hihia kūikawā hiki ke loaʻa.

ʻO nā maʻi hanana Digestive e like me ka nausea, nā hoʻololi i ka ʻono ʻana, ʻae hopohopo i ka leʻaleʻa, ka ʻōpūʻawa, ka stomatitis, ka ʻeha ʻana ka mea maʻamau. Kuhi loa paha, ʻikea ka diffunction a me ka hepatitis i kēia kuhikuhi.

Ma ka ʻaoʻao o ka momona thyroid, hiki ke ʻike ʻia ka hoʻonui ʻia ʻana o ka umauma ma nā wahine a me kahi hōʻino o ka potency i nā kāne. ʻO ka hopena maʻamau no kekahi mau kāne ʻo ka emi ʻana o ka libido. I ka hana o ka puʻuwai, nā arrhythmias, tachycardia, dizziness, hōʻailona indonseches i ka wā o kahi electrocardiogram a pēlā aku.

Pono e nānā pono i ka papa inoa o nā hōʻike pilikino hikiʻole i ka ʻōnaehana. ʻOiai ke kūpono nei o ka lāʻau e hoʻokō pono nei i kona kū ʻana, ʻo ka hapa nui o ka hopena o ka hopena e pili pū me ia.

No laila, e ʻike paha nā mea maʻi:

• hopohopo
• hiamoe
• hoonui nui
• mai nāwaliwali
• ʻōlelo pilikino
• hilahila
• hoʻokūkū maʻi
• poʻomanaʻo
• ʻōpala
• moeʻuhane i loko o ka moeʻuhane
• hoʻonui i hopu ʻia i nā epilepsy.

Nā ʻōlelo ʻokoʻa

ʻO nā mea maʻi e kau nei i ka lāʻau ʻo Amitriptyline e noʻonoʻo pono i ka mea hana e hiki ai ke hoʻomau i ka haunaele i ka wā o ka neʻe i ka hele ʻana i kahi kūlana kūpono, no laila e hoʻomaikaʻi maikaʻi ʻoe. Eia kekahi, me kahi lōʻihi o ka lāʻau lapaʻau a me kahi keʻakeʻa koʻikoʻi o ka mālamaʻana, hoʻomohala i nā hōʻailona no ka haʻalele.

No ka like ʻole ka lāʻau lapaʻau me nā lāʻau lapaʻau e pale ana iā MAO, pono lākou e hoʻomaka i ka lāʻau lapaʻau ma mua o 2 mau pule ma hope o ka hoʻopaʻa ʻana i nā lāʻau lapaʻau i luna.

Pono e hoʻomaopopo mau ʻia nā kauka e pili ana i ka lawe ʻana i kēia lāʻau lapaʻau, ʻoiai no ka mea hiki ke pili i ka hopena o nā lāʻau lapaʻau ʻē aʻe. Pono hoʻi e hoʻokaʻawale i ke kaʻina pule me ka ephedrine, phenylephrine a me nā mea like.

I nā poʻe maʻi maʻi makua, ʻo ia hoʻi ka poʻe e nānā ana i ka hoʻomaha o ka moena a loaʻa ka liʻiliʻi, hiki i ka lāʻau lapaʻau ke hana i ka pōkole pila. ʻO kekahi hopena paʻakikī i ke kino ma ke ʻano o ka electrotherapy e ʻae ʻia ma lalo o ka mākaʻikaʻi koʻikoʻi o nā kauka.

ʻO ka hoʻohana lōʻihi ʻana o ka lāʻau lapaʻau e hiki ke hoʻonāukiuki i ka hiʻohiʻona o nā mākaia a me ka pono no ka hoʻohana hou ʻana i ka riboflavin.

Inā hoʻoholo ʻia ka lāʻau lapaʻau i ka mea maʻi i kekahi lā i kēlā me kēia lā i ʻoi aku ma mua o 150 mg, a laila la ke kahakaha aʻe o ka piʻi ʻana o nā mea i loko o ke kino e hoʻonāukiuki i ka nui o nā kuʻuna epileptic a me kahi hōʻike hoʻomohala o ka hoʻomanawanui i nā maʻi ʻē aʻe i loko o nā maʻi ʻē aʻe. Me ka hoʻohana ʻana i ka lōʻihi, pono ia e noʻonoʻo pono i nā mea maʻi e loaʻa i nā tendic suicidal, ka mea, me ka hoʻolōʻihi o ka lāʻau.

Ke noi ma lalo o nā kūlana

I ke wā kamaliʻi, hoʻohana ʻia ka lāʻau lapaʻau mai nā makahiki 6 paha i ke ʻano o nā papa. ʻO nā laha injection e pili ana i nā palena nui aʻe. Hiki iā lākou ke hoʻohana no nā keiki wale mai nā makahiki he 12.

Ma ka wā hāpai, ua pāpā ʻia ka lāʻau lapaʻau, no ka mea, e like me ka noiʻi, hiki i ka hopena maikaʻi loa i ka hoʻomohala ʻana o ka wī. Hoʻohana ʻia ka hoʻohana ʻana o ka lāʻau lapaʻau i nā hihia maʻamau loa a i ka trimester lua wale nō, inā ke hoʻopiha piha ʻia ka pōmaikaʻi hiki i ka hōʻeha. Pono nō hoʻi e pani i ka hoʻōla i ka manawa i hiki ʻole ai ke pēpē e hoʻoulu i ka maʻi withdrawal ma hope o ka hānau ʻana. Pono e hoʻokuʻu ʻia ka lāʻau ma ka liʻiliʻi he 7 mau hebedoma ma mua o ka lā e manaʻo ʻia ai ka hānau hānau.

I ka wā e hānai ai, ʻaʻole i hoʻohana ʻia ʻo "Amitriptyline Nycomed" no ka mea, ʻo ia ke hana i ka hiamoe a me ka addiction i nā keiki.

I nā poʻe maʻi maʻi, mea pinepine ka lāʻau i ka pōʻino o ka ʻōpū, kahi e hoʻokaʻawale i ka hōʻailona a i ʻole ke hoʻololi ʻana i ka lāʻau lapaʻau me kekahi. I loko o ʻōpio mau, hiki i nā lāʻau lapaʻau i nā lāʻau lapaʻau, i pinepine i ka hopena ma hope o ka hoʻokuʻu ʻana o ka lāʻau lapaʻau i ka pō.

"Amitriptyline Nycomed" (25 mg) nā loiloi o nā maʻi ʻike i hōʻiliʻili ʻia. ʻO ka hapa nui o nā mea e hoʻomaʻamaʻa ʻia me kēia lāʻau lapaʻau, ua piha loa i ka hopena a ʻike wale ʻia ka maʻi lahilahi i ka wā o ka ʻoihana. ʻO ke kumukūʻai haʻahaʻa, loaʻa i kekahi kanaka, e hōʻike ʻokoʻa i waena o nā pono o ka lāʻau lapaʻau, ʻoiai ʻoiai ke noʻonoʻo nei ka lōʻihi o ke ʻano o ka mālama ʻana i kekahi mau mahina. Ma ka laulā, ke nānā nei i kekahi mau hiʻohiʻona maikaʻi, ʻike nui nā mea a pau i kona kū pono. Kōkua ka lāʻau lapaʻau i nā mea maʻi i kahi manawa pōkole e hoʻoiho i nā maʻi noʻonoʻo hope loa a hoʻi hou i ka hauʻoli o ke ola.

I waena o nā minuke o nā papa, loiloi i nā hopena ʻaoʻao. ʻO kaʻoiaʻiʻo, ʻo ka hapanui e hōʻike ana i hala lākou i ke manawa, akā i kekahi mau hihia ʻaʻole like kēia. Inā ʻaʻole e hōʻoki ka mea maʻi ʻo ka hoʻomake ʻana i nā hōʻike hou ʻole mai ka lawe ʻana i ka lāʻau lapaʻau, a laila pono ia e ʻimi i ke kauka no laila e hoʻohuli ʻo ia iā ia me kahi ʻano lāʻau ʻē aʻe.

ʻO kaʻoiaʻiʻo, ʻike pinepine ʻia nā loiloi maikaʻi loa mai kēlā poʻe nāna e hoʻoholo e lawe i ka lāʻau lapaʻau ponoi ma luna o lākou iho, no ka mea, ke kūʻai aku ʻole ʻole ʻia mai kahi kauka. Mai ke kika kūpono helu i loaʻa iā lākou nā pilikia. Wahi a nā loiloi mai nā kauka, hiki ke hoʻokaʻawale ʻia kekahi ʻano hōʻike maikaʻi ʻole e ka noʻonoʻo pono ʻana i nā ʻano o kēlā me kēia ʻano o ke kino a me ka hoʻomanawanui ʻana o ka maʻi.

Hoʻohālikelike

ʻOiai ka mea o ka honua āpau i kahi nui nui o nā lāʻau like ʻole no ka maʻi noʻonoʻo, akā naʻe, pono mau iā ʻoe e pale iā ʻoe iho. Mai hoʻouka iā ʻoe iho me ka hana hou, inā hiki, e hoʻāʻo e hele pinepine, hele i nā hanana moʻomeheu, a hoʻolimalima manawa me kāu mau mea aloha. Mai poina e pili ana i ka hiamoe maikaʻi. A eia wale nō, mai makaʻu ʻoe i kekahi kaumaha.

Hoʻohana i ka wā hāpai a i ka wā o ka umauma

Kahawai
Ua hōʻike ʻia nā haʻawina holoholona i nā hopena ʻaoʻao i nā papa i kekahi mau manawa kiʻekiʻe aʻe ma mua o ka nui o ka maʻi kanaka maʻamau.
Hoʻololi ka ʻike ʻoihana maʻi me ka amitriptyline i ka wā hāpai.
ʻAʻole paʻa i ka palekana o ka amitriptyline i ka wā hāpai.
ʻAʻole kōkua ʻia ʻo Amitriptyline i ka wā o ka hapai ʻana, ʻoiai inā ma mua o ke kolamu mua a ʻekolu, ke ʻole ka loaʻa ʻana o ka pōmaikaʻi i ka makuahine ma mua o ka hopena o ka wahine hāpai.
Inā hoʻohana ʻia ka lāʻau lapaʻau e nā wahine hāpai, pono nō e ao e pili ana i ka kiʻekiʻe o ke kaʻa o kēia hoʻokipa no ka pēpē, ʻoi aku hoʻi i ka trimester III o ka hāpai ʻana. ʻO ka hoʻohana nuiʻana i nā dosis kiʻekiʻe o nā antidepresi tricyclic i ke kolu o ka hapalua o ka hapai hiki ke alakaʻi i nā pilikia neurological i loko o ka pēpē.
Aia nā hihia o ka ʻehaʻeha me nā pēpē hou i hoʻohana ai nā makuahine i ka nortriptyline (kahi metabolite o amitriptyline) i ka wā hapai, a ua nānā ʻia nā hihia o ka noho urinary.
Haumakua
Ke hoʻohana ʻia i ka amitriptyline, pono e hōʻoki ʻia ka umauma. Hele akula ʻo Amitriptyline i ka waiū umauma. ʻO ka hoʻohālikelike o ka waiū umauma / plasma he 0.4-1.5 i loko o kahi pēpē i hānai ʻia. Hiki i nā hopena leʻaleʻa.

ʻLoe a me ke kākele

Hāʻawi i loko o ka ʻole o ka hamo ʻana (ma hope koke o ka ʻai).
Nā pākeke
ʻO ka dosis mua ma kēlā me kēia lā he 25-50 mg, hoʻokaʻawale ʻia i ʻelua pona, a i ʻole he ʻano helu hoʻokahi ma mua o ka hiamoe. Inā pono, hiki ke hoʻonui ʻia ka nui o kēlā me kēia lā i 200 mg.
ʻO ke ʻano maʻamau o ka mālama maʻamau ka 6 mau mahina a keu paha e pale ai i ka hoʻohemo ʻana.
ʻO nā elemakule
ʻOi aku ka maikaʻi o nā poʻe'ōpiopio i nā hopena undesirable m-anticholinergic o ka amitriptyline. No laila, no lākou, ʻo ka papa hana i kauoha ʻia ʻo 25-30 mg / lā., Ma kahi o ka manawa 1 ka lā (i ka pō). Pono e hoʻonui ʻia ka nui ma ka hopena, i kēlā me kēia lā, e hōʻea, inā pono, nā kaha o 50-100 mg / lā, a hiki i ka hopena (hopena) e loaʻa. Pono pono kahi hōʻike hou ma mua o ke kuhikuhi ʻana i kahi papa e lua no ka mālama ʻana.
Hola paʻa kino hana
I mua o ka hana renal impaired, hiki i ka lāʻau lapaʻau ke hoʻohana i ka nui maʻamau.
Hōʻeha ka hana ʻoluʻolu
I nā maʻi me ka maʻi hepatic, e hoʻemi ʻia ka nui o ka amitriptyline.
Hoʻolālā lōʻihi
Hōʻike pinepine ʻia ka hopena antidepressant ma hope o 2-4 mau pule.
Hoʻomaʻamaʻa ka lāʻau lapaʻau Antidepressant, a no laila e lōʻihi ke lōʻihi, maʻamau no 6 mau mahina a keu paha, e pale ai i ka hana hou o ke kaumaha.
Hoʻopau
Pono e hoʻokuʻu iki i ka lāʻau pono e pale i ka hoʻolālā ʻana o ka "withdrawal" syndrome, e like me ke poʻo, ka holo ʻana o ka hiamoe, huhū a me ka maʻi maʻamau. ʻAʻole kēia mau hōʻailona i ka hōʻailona me ka hilinaʻi o ka lāʻau lapaʻau.

Loaʻa ka hopena

ʻOi aku ma mua o 50% o nā maʻi e loaʻa ana i ka lāʻau lapaʻau Amitriptyline Nycomed paha i hoʻokahi a i ʻole nā ​​hopena hou aʻe o kēia hopena. Hiki i Amitriptyline ke hopena i nā hopena o nā hopena e like me nā mea i hoʻoiho ʻia e nā antidepresi tricyclic.
ʻO kekahi o nā ulia pōpilikia i hōʻike ʻia ma lalo nei, e like me ke poʻo, ka haʻalulu, ka hoʻohaʻahaʻa i ka kiko o ka nānā, constipation, a me ka hoʻohaʻahaʻa ʻana i ka moʻo ʻana o ke kāne, hiki nō hoʻi i nā hōʻailona o ke kaumaha, a e nalowale lākou me ka emi haʻahaʻa.
Hōʻike ʻia ka mea i nā hopena o ka hopena e like me: pinepine pinepine (> 1/10), pinepine (> 1/100, 1/1000, 1/10 000, mai ka ʻōnaehana cardiovascular:
Pinepine pinepine: palpitations a me ka tachycardia, aotostatic hypotension.
I ka manawa pinepine: arrhythmia (me nā pīhoihoi hoʻomaha, hoʻolōʻihi i ka manawa QT), hypotension, AV block, conduction block ma nā wāwae o ka pūpū o kāna.
Kaka: hoʻonui i ke koko.
ʻArelelo: myocardial infarction.
Mai ka ʻōnaehana hoʻonāukiuki:
Pinepine pinepine: pākaʻi sedative (lethargy, condencies to sleep), nā mea hana, nā maʻi hōʻemi, headache.
I ka manawa pinepine: hoʻemi i ka span nānā, ʻeha hopohopo, paresthesia, extrapyramidal hōʻailona: ataxia, akathisia, parkinsonism, dystonic reaction, tardive dyskinesia, waha retardation.
Kaka: nahoa.
Mai ka urinary system:
I ka manawa pinepine: mālama urinary.
Ma ka ʻāpana o ka ʻili.
Pinepine pinepine: hipehuxikisis.
Kaka: ʻohi, hoʻopau vasculitis, urticaria.
ʻArelelo: photosensitivity, alopecia.
Mai nā ʻike:
Pinepine pinepine: ka hoʻemi ʻia o ke kōkuhi ʻike ʻike, kōpaʻa i ʻole ke kau (pono paha e noi ʻia nā aniani i ka wā e mālama ai).
I ka manawa pinepine: puaa.
Kaka: tinnitus, hoʻonui intraocular pressure.
ʻArelelo: ka nalowale o ka noho noho hoʻokipa, hoʻomānoino o ka glaucoma kūwili kikowaena.
ʻO nā maʻi noʻonoʻo:
Pinepine pinepine: hūnā (hūnā i nā mea maʻi maʻi hānai me ka hopohopo, ke hiamoe ʻana, a me ka hopohopo ʻana, hoʻoweliweli, psychologotor agitation, disordered manaʻo, delirium), hilahila.
I ka manawa pinepine: hoʻemi ʻia ka pane ʻana ʻana.
Kaka: nā hemahema cognitive, manic syndrome, hypomania, mania, ʻano ʻike i ka makaʻu, hopohopo, insomnia, ʻike ʻia i ka pō.
ʻArelelo: huhū, hoʻāhewa ʻia (i nā pākeke), nā mea hoʻowalewale (i nā mea maʻi me ka schizophrenia).
Loa loa: manaʻo noʻonoʻo suicidal.
Mai nā ʻekopa hemopoietic:
ʻArelelo: ka pale ʻana i ka hana o nā mea he kumuwaiwai, agranulocytosis, leukopenia, eosinophilia, thrombocytopenia.
Mai ka pūnaehana hana ʻana
Pinepine pinepine: hā maloʻo, constipation, nausea.
I ka manawa pinepine: ke kūlohelohe o ke kao, hoʻomāpeʻe i ka lua o ka waha, hoʻopau o ka niho, ka hoʻopau ʻana i ka ʻāʻī ma ka waha.
Kaka: ʻalaʻeha, huʻi ʻia, hao ʻana i ka alelo.
ʻArelelo: pākīpī paralytic, ka hooke ana o ka lula parotid, jaundice cholestatic, hana o ka pehu aihue, hepatitis.
Nā maʻi maʻamau:
I ka manawa pinepine: nāwaliwali.
Kaka: ka ʻōpū o ka maka.
ʻArelelo: fiva.
Mai ka ʻaoʻao o ka metabolism:
Pinepine pinepine: ua hoʻonui ke kaumaha momona.
ʻArelelo: hoʻemi i ka momona.
Loa loa: hoʻonāukiuki o nā hana huna ʻole o ka hormone antidiuretic.
Mai ka ʻōpiopio:
Pinepine pinepine: nāwaliwali a i ʻole ka hoʻonui ʻana i ka makemake moekolohe.
I ka manawa pinepine: i loko o nā kāne - nā poʻe pau ʻole, ke kau palena.
ʻArelelo: i nā kāne - e hoʻokuʻu ana i ka ejaculation, gynecomastia, i loko o nā wāhine - galactorrhea, pani orgasm, nalowale i hiki ke hoʻokō i nā orgasm.
Nā hōʻailona kuhikuhi:
I ka manawa pinepine: Hoʻololi ka ECG, hoʻonui i ka palena QT, hoʻonui i ka paʻakikī QRS.
ʻArelelo: ka haʻalele ʻana mai ke ʻano o nā hoʻokolohua o ka ate, hoʻonui i ka hana o ka phosphatase alkaline, transaminases.
ʻO nā hopena hopena
Hoʻomaka ākea ka hoʻomaʻamaʻa ʻana ma hope o ka hoʻohana ʻana i ka lōʻihi o ka manawa ma muli o ka nausea, ka ʻūhā, a me ka malaise hoʻi.
ʻO ka wehe iki ʻana o ka lāʻau lapaʻau ua pili me nā hōʻailona transient e like me ka irritability, agitation, a me nā pōʻino o ka moe a me ka hiamoe i loko o nā pule ʻelua ʻelua o ka hōʻemi o ka hopena.
Kēia hiki iki aku i nā hihia pilikino o kahi manic a i ʻole hypomania i loko o 2-7 mau lā ma hope o ka pau ʻana o ka mālama lōʻihi me ka tricyclic antidepressants.