ʻO Glibomet kahi hui waha (no ka hana o loko) hypoglycemickā kumu bitanide a huikaʻiʻElua hanauna e hōʻike ana extrapancreatica pancreatichana.

Kūkala huikaʻiII ka hanauna - glibenclamidehe hopena hoʻoikaika i ka ʻiliʻu insulinma ka hoʻohaʻahaʻa ʻana i ke anuanu me kahi paepae ʻole o ka beta hoʻonāukiuki pancreas.

ʻO Glibenclamidehoʻohui i ka hiki i insulinme ka ikaika o kāna mau mea paʻa me nā cell target e hoʻonui i ka hoʻokuʻu insulin, hoʻonui i kona hopena ma ke kaʻina haʻiliʻi ʻaina ake ka pale ʻana a me ka mākala ma loko o ka adipose tissue Lipolysis. ^ E Ha yM. Hōʻike ʻia ka hopena o ka lāʻau i ka lua o ka hana o ka hana insulin.

Kūkala biguanide– metforminhōʻike i kahi hopena hoʻoulu e pili ana i ka hoʻihoʻi ʻana i ke kōpili i nā hopena insulin(hoʻonui i ka loulou receptor insulina hoʻonui i kona mau hopena ma ka pae postreceptor).

Ma ka wahī haʻiliʻi ʻainanā wahi hopohopo gluconeogenesis a pili pono lipid metabolism kōkua e hōʻemi i ka momona nui i nā maʻi maʻi maʻi. ^ E Ha yM. Loaʻa ia i ka hopena o fibrinolytic ma muli o ke kaohi ʻana i ka mea hoʻouluulu hoʻoponopono plasminogen.

Hoʻopilikia ka hopena hypoglycemic of Glibomet ma hope o 2 mau hola a nānā i nā hola 12.

Hoʻohui pū i ka sinnergistic o nā ʻano hana ikaika o ka lāʻau lapaʻau - ka hopena hoʻoulu ʻana i ka derivative huikaʻie hoʻopua i kāu insulin ponoʻī (pancreaticka hana) a me nā hopena pololei biguanidema ka pili adipose a me ka ʻiʻo (extrapancreatichana - ke hoʻonui nui ʻana i ka assimilation kekuhi) a me ka lau o ke kino (hoʻoemi gluconeogenesis), e ʻae i kahi hapa o nā pona i hōʻemi i nā mea o kēlā me kēia kumuhana.

E kōkua kēia kūlana i ka haʻalele ʻana i ka hiki ʻana aku. Nā hua beta ma ka pancreas, a penei i hōʻemi ai i ka hōʻemi o nā hana i kau ʻia, a me ka hoʻonui ʻana i ka palekana i nā aihue hypoglycemic a hōʻemi i ka nui o nā hopena ʻaoʻao.

Hoʻopau glibenclamidema ka huehue hanana kū koke a hiki i kahi kiʻekiʻe kiʻekiʻe (84%). Kuhi ʻia ka paonaʻana ma hope o 1-2 mau hola. ʻO ke kamaʻilio me ka protein protein i ka pae o 97%. Aneane hiki i kāmoa (a hana ʻole i ka metabolites) ma loko o ka mōʻī. Hoʻohui ʻia a me ke kuʻi a me ka urine ma kahi pānaʻi o 50/50%, me kekahi hapa hapalua o 5 a 10 mau hola.

Hoʻopilikia i ka hana o ka digestive tract metforminpiha pū kekahi. ʻAʻole hiki i ka mea make ke hoʻopaʻa ʻia i ka protein plasma a pālahalaha koke i nā kiko. ʻAʻole paʻapaʻa ke kino. Hoʻokuʻu ʻia ia ma nā ʻāpana a me kahi hapa liʻiliʻi e nā ʻōpū, me kekahi hapalua o ke ola o ka hola 7.

Nā hōʻailona no ka hoʻohana ʻana

Ke hōʻike ʻia nei ka lāʻau lapaʻau ʻo Glybomet no ka lāʻau lapaʻau diabetes type 2i ka hihia o ka hooikaika ole lāʻauʻai meaʻaia me ka hana kūpono nā biguanideskahi hānō huikaʻilike me nā lāʻau lapaʻau hypoglycemic waha.

Nā Hoʻohui

• haaheo i glibenclamide(komo pū ʻia huikaʻi), metformina i ʻole nā ​​mea like o ka lāʻau lapaʻau,
• maʻi maʻi maʻi gestational
• maʻi diabetes type 1,
• lactic acidosis(komo moʻolelo),
• precoma ketoacidosiscoma (maʻi)
• nā kūlana i hōʻike ʻia e ka hemahema o ka meaʻai a me ke kūkulu ʻana o hypoglycemia,
• nā hopena pilikia ma ka hopena huehue ialanā maʻi ʻeha loa huehue, pihoihoi, ka hoʻomakaʻana o ka hoʻohālikelike iodine-i nā mea (intravascular),
• hana hepatic hana,
• ke ʻano o nā kuʻuna (me mea hana no nā kāne he oi aku ma kahi o ka 135 mmol / l a no nā wahine he oi ma mua o 110 mmol / l),
• nā kūlana me hypoxia(ka ʻōpū a i ʻole puʻuwai paʻakikīhūnā ma mua myocardial infarctionnā pilikia hōʻeha nui o ka ʻeha ʻana)
• gangrene, nā maʻi ʻeha, pālahalahahoʻōki kūlokopoho nui koko nui, nā hōʻehanui loa kuniʻaa me nā mea e pono ai ʻōpū insulin,
• 48 mau hola ma mua a i hope wawao opalaa paʻa paha radiologiea i ʻole radioisotopehōʻike me ka hoʻokomo ʻana i kahi mea i ʻike ʻia no ka iodine,
• leukopenia,
• nā loli dystrophic (lipodystrophy, myotonic dystrophy),
• porphyria,
• mālama ʻaʻano kai hypocaloric (a i luna o 1000 kcal i ka lā),
• hāwā hoʻohālikelikewaiʻona ka ʻaloʻakā maʻi,
• Iʻa nele o ka glucose-6-phosphodehydrogenase,
• makahiki a hiki i ke 18 mau makahiki
• hapaia hānai wahine.

Mai ʻōlelo e lawe aku i ka Glybomet i nā poʻe maʻi i ʻoi aku ma mua o 60 mau makahiki he nui ka hana ma ka hana kino koʻikoʻi, ma muli o ka hoʻonui nui o lactic acidosis.

• kaumaha kaumaha kino (i ka hopena o lactic acidosis),
• palolo pani ʻia,
• ʻiliʻala maʻi,
• hypofunctionʻōpala nā kuhihewa adrenala / a i ʻole he poʻomanaʻo alo huakai walionary.

Nā hopena hopena

• nā maʻi ʻaole,
• ninini,
• ʻōpū nui
• utuka,
• ka hoʻāʻo ʻana o ka ʻala ma ka lua o ka waha,
• nā ninia,
• hoʻoulu o nā ate enzyme.

• hememia anemia,
• leukopenia
• erythrocytopenia,
• thrombocytopenia
• anemia megaloblastic,
• agranulocytosis,
• pancytopenia.

Inā ʻike ʻia nā mea hōʻike lactic acidosis(nāwaliwali maʻamau, ʻeha o ka ʻōpū, ka luaʻi ʻana, nā ʻōpū o nā hoʻi), pono ʻoe e ho'ōki i ka lawe ʻana i nā papa Glibomet a nīnau aku i kahi kauka.

• e like me ka disulfiram-like manaʻohōʻike ʻia i ka wā e lawe ʻia ai waiʻonaa hiʻohiʻona ʻulaʻulaʻōpū ʻāuli a me ka ʻili o ka ʻili, lie kanikelamanaʻo puʻuwai puʻuwai, nininia ka lua huikau hoʻonui i ke koko.

Nā papa papa glybomet, nā ʻōlelo e hoʻohana ai no ka hoʻohana

Hoʻomaopopo nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana iā Glibomet i ka lawe ʻana i nā papa lāʻau lapaʻau ma mua (ma loko), maikaʻi me nā meaʻai.

Koho ʻia ka nui o ka maʻi me ka lōʻihi o ke kau ʻana e ke kauka komo e pili ana i ke ʻano kaloli hoʻomanawanui a helu koko kekuhi.

ʻO ke kānāwai, ʻo ka lākau mua o nā lā he 1-3 mau papa, me ka hoʻololi hou ʻana i nā maʻi i koho ʻia e pili ana i ka hopena, ʻo ia ka mea e hōʻoia ai i ka normalization o nā manaʻo. kekuhi i loko o ke koko.

ʻO ka papa helu ʻokoʻa loa i kēlā me kēia lā he 6 papa.

Ke keu

Me kahi overdose, ua hoʻomaopopo ʻia ka hoʻomohala ʻana hypoglycemia(glibenclamide) a ā lactic acidosis(metformin).

I hypoglycemia nānā: pōloli, pōloli nāwaliwalimāhuahua kaohuunā maʻi neurological (ka pōkole) puʻuwai puʻuwai, aloha i ka ʻōlelo waha palikaʻili kūloko hāpau, poʻomanaʻomanaʻo hopohopopathological hiamoeka manao o ka makaʻu nā hiamoe hiamoe, nele i ka hoʻonohonoho ʻana. ^ E Ha yM. Me ka holomua o kēia ʻano i hoʻomaopopo ʻia ka nalowale ʻana o ke kāohi ponoʻī a o ka maopopo.

Ma na koi o hypoglycemiaManaʻo nā meaʻai māmā i nā hilo, nā mea inu a me nā meaʻai paha i loaʻa ka nui kalapu(meli, jam, kīhai ʻoluʻolu). Inā hypoglycemiakeu me nalowale o ka ike ana, iv paipai i ka hopena o 40% hoʻolaha(kekuhi) i ka waihona o 40-80 ml, ma hope o ke kuhikuhi ʻana o kahi infusion o 5-10% hoʻonā hoʻolaha. ^ E Ha yM. Ma hope iho, he hiki ke hoʻonohonoho hou o ka 1 mg. nāonaona.

Inā noho ka mea maʻi i loko maopopo ole e hana hou ʻia nā hana ma luna. ʻO ka nele o ka hopena i kēia hihia, hoʻonui i ka mālama pālia.

I lactic acidosiskuhi: haʻi ʻia nāwaliwalinā maʻi hanu ʻāʻā naʻau, hiamoe, ka ʻōpū, ka ʻōpū o ka ʻōpū, heokeohoʻohiʻohi briearrildia, nā niniae hoʻohaʻahaʻa i ke koko, hypothermiahilahila analowale o ka ike ana.

Ma ka hihia o ka kānalua o lactic acidosise hoʻolohi koke i ka lāʻau lapaʻau, hokahoʻomanawanui a hoʻokō i ke kaʻina hana hemodialysis.

Hoʻohui

Hoʻohui ʻia nā hopena hypoglycemic o Glybomet i ka wā i hui pū ʻia me derivatives dermarin (Sinkumar, Warfarin), nā beta-blockers, nā salicylates, PolohanaHula, ʻO Cimetidine, Allopurinol, sulfonamides, MAO e kālai ʻia, Probenecid, Phenylbutazoneme nā huakai, Kelekaeka, Sulfonamide, huakai ʻiwahope, Pergexilin, ʻO Miconazole (waha) Feniramidol, Sulfinpyrazonea ethanol.

Hoʻopau i nā Glucocorticoids, adrenalinewaha mea hoʻohālikelikepani ʻia diuretics thiazide a me ka hoʻōla ʻana o ka hormone thyroid i ka maikaʻi o ka maʻi o Glybomet.

Ma muli o ke ʻano o ka lawe ʻana i Glibomet, hiki i ka nui o nā hopena anticoagulants.

Hōʻailona kaila ʻO Cimetidinehoʻonui i ka loli o lactic acidosis.

Nā māka hua Beta hiki ke hōʻike maka ai hypoglycemia(ʻo ka ʻokoʻa ke hoʻopau ʻana).

Ke noi radiopaquenā mea hana iodine (no ka hoʻokele intravascular) hiki ke alakaʻi i ka hana ʻole a me ka piha o metformin (ka pilikia o ka hanana lactic acidosis).

Nā ʻōlelo kikoʻī

I ka wā o nā papa lapaʻau, pono e hoʻopiʻi nui nā mea maʻi i nā ʻōlelo a ke kauka a pau e pili ana i ka dosis a me ke ʻano o ka hoʻohana ʻana i ka lāʻau, regimen ka hoʻoikaika kinohāpai kākaʻaia me kāʻohi pono pae ʻai glucosei loko o ke koko.

Lactic acidosis- he wahi ʻonaʻehā, akā ʻo ka mea pōpilikia kekahi kūlana pathological nāna i hōʻike iā ia iho ka huina o ka lakū lactic i ke koko ma muli o ka hōʻiliʻili ʻana metformin. ^ E Ha yM. Nā Nā Hana ʻike lactic acidosisi ka poʻe maʻi e lawe ana Metforminpinepine i kiaʻi i nā maʻimaʻi maʻi me ka lahilahi i haiia hālohelohea puʻuwai paʻakikī.

I mea e pale ai i ka hiki lactic acidosispono e ʻike ʻia nā mea pili i pili ʻia, e like me: ketosisdecompensated diabetes, lōʻihi pololi, pūpū hemahoala inu ʻona a me kekahi kūlana e alakaʻi ana i hypoxia.

Ke hoʻomau nei ʻoe i ka maʻi Glybomet, pono kia nānā ʻia ka likia o ka serum, ma ka liʻiliʻi loa 1 ka manawa me 12 mau mahina me ka hana o ka maʻamau maʻamau a ma ka liʻiliʻi o 2-4 mau manawa i ka 12 mau makahiki o ka makahiki a me mea hanakokoke i VGN.

Pono e mālama kūikawā i nā hihia. lawelawe inoa ʻole (ka hoʻomaka o ka mālama ʻana Nā NSAID, antihypertensivenā lāʻau lapaʻau diureticʻoā).

Pono e hoʻopau ʻia nā lāʻau glybomet 48 mau hola ma mua x-ray hōʻike me ka inikake iv o kahi kaawale nā mea iodine(i kēia manawa o ka manawa, pono e lawe ʻia i nā lāʻau lapaʻau hypoglycemic ʻē aʻe).

Eia kekahi, ʻo ka hoʻopau ʻana i ka lāʻau no nā hola 48 e pono ai kahi papa hana hoʻolālā i hoʻolālā ʻia ma lalo anesthesiame huʻi a i ʻole ʻuʻuku kikowaena.

Hiki ke hana hou i ka mālama ʻana ma hope o ka mea maʻi i ka hānai waha a i ʻole mau hola 48 ma hope o ka hana, e kūpono ʻia i ka hana maʻamau o nā kuli.

Pono e mālama ʻia ma ka mālama ʻana i kahi kaʻa a e hana ana i nā hana kūpono a koʻikoʻi.

Nā mea hoʻohālikelike o Glybomet

ʻO nā mea e pili kokoke ana iā Glibomet i ka hopena o kā lākou hopena e hōʻike ʻia ana e nā lāʻau lapaʻau.

• Bagomet Plus,
• Kūkākūkā,
• Kūkākūkā,
• Hoʻolauleʻa,
• Metglib.

Hoʻopili ʻia ka hoʻohana ʻana o Glibomet a hiki i ka makahiki 18.

Me ka waiʻona

Ethanol, e like me nā mea inu ʻona, hiki ke hoʻonāukiuki hypoglycemiaa me ke kumu e like me ka disulfiram-like manaʻo (ʻeha, hōʻeha, āhāhuʻe, nininika ʻā ʻana o ka wela i ke kino ma luna a me ka ʻili o ka ʻili, utuka, tachycardia, poʻomanaʻo), e pili ana me ka mea, pono ʻoe e haʻalele i ka hoʻohana ʻana i ka waiʻona i nā ʻano āpau āpau.

Hōʻikeʻike o Glibomet

I waena o nā mea maʻi e lawe nei i kēia lāʻau lapaʻau, ʻike maikaʻi ʻia ka loiloi o Glibomet, ʻoiai me kekahi mau loulou i nā ʻano ʻokoʻa, pinepine, a me nā hopena ʻokoʻa.

Nui ka poʻe i ka ʻeha diabetes type 2e lawe i nā papa Glibomet i hui pū me nā poʻe ʻē aʻe nā mea lawelawe hypoglycemic nolaila, ʻaʻole hiki iā lākou ke hōʻoia me ka maikaʻi o kēia lāʻau lapaʻau.

ʻO nā poʻe maʻi ʻē aʻe i kuhikuhi ʻia iā Glibomet i nā wā i hala aku nei ʻaʻole i māʻona me kona mau hopena a huli ʻia i nā lāʻau lapaʻau ʻē aʻe o kēia hopena. Hōʻike kēia mau mea i ka maʻimaʻi mellitus maʻiʻi pono ʻoe e hoʻokokoke pānaʻi iā ia iho, a ʻaʻohe kumu ʻole o ke ʻano like o ka lāʻau like ʻole no nā maʻi āpau.

ʻO kekahi pilikia ʻē aʻe o nā lāʻau hoʻohui pū, ʻo ia ka paʻa o nā kikoʻī mau loa o nā mea ikaika, i kahi kūpono loa i kēlā me kēia maʻi.

Hiki iā mākou ke hoʻololi i ka hihia inā kūpono ʻo Glybomet no ka mea maʻi i nā palaleka āpau, e hoʻomau ka maikaʻi o kahi pae kiʻekiʻe, a me kekahi, ʻoiai, i ka pane ʻole ʻana o ke ʻano o ke kino i nā mea o ka lāʻau, ʻoi aku ka maikaʻi o ka hoʻololi i kekahi lāʻau lapaʻau ʻē aʻe.

Pono ia e hoʻomanaʻo i kēlā me maʻi maʻi wale nō ke kauka hiki i ke kuhikuhi ʻana i ka mālama ʻana, hoʻoponopono i nā hala a me nā hoʻoponopono ʻona.

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana a me ka pōpoki

Hana ʻia ʻo Metglib i ke ʻano o nā papa convex ma nā ʻaoʻao ʻelua, i kahi palani paleʻulaʻula, a keʻokeʻo i ka ʻāpana.

• 500 metformin hydrochloride,
• 2.5 ka glibencamide,
• 12 sodium 12 kaleka,
• 45 keʻa palaoa,
• 50 kaleha pākia waikawa dihydrate,
• 52 povidone
• 3 sodium stearyl fumarate,
• 35.5 microcrystalline cellulose.

Hele mai ka lāʻau lapaʻau i nā ʻano ʻano ʻelua:

• 2,5 mg glibenclamide, 500 mg metformin,
• 5 glibenclamide, 500 metformin.

Hoʻokomo ʻia nā poli ma kahi pahu kīwaha, i ka manawa i hiki ai iā 30 a 40 mau papa paha.

Nā mea hana INN

ʻO ka inoa inoa honua no ka lāʻau ʻo Glibenclamide a me Metformin.

Hoʻolauna ʻo ia i kāna hui ʻo Canonfarm, Rusia. Kāleka: Moscow wahi, Shchelkovo, st. Zarechnaya, 105, index 141100.

ʻO ka kumukūʻai kiʻekiʻe o ka lāʻau lapaʻau he 140 mau rubles no ka pākahi no 30 mau ʻāpana. Ma ka laulā, kahi mea pono hana, ʻoiai inā kauoha ʻia ma ka pūnaewele.

Ka hana lāʻau lapaʻau

ʻO kēia kahi laila hui pūpū i loaʻa i ka metformin a me glibenclamide. ʻO kāna kumu nui ʻo ia ka hoʻohaʻahaʻa i ka glucose koko. Mahalo i ka hui pū ʻana o nā mea o luna, ua ikaika kēia hopena.

Hoʻopau ka Metformin i ka hoʻoliʻiliʻi o ke kō i loko o ke koko, ʻaʻole ia ka mea e hoʻokuʻu ai i ka insulin, hoʻonui i ka ʻike ʻana o nā ʻili i ka glucose, e kōkua i ka hoʻohemo ʻana o kona komo ʻana i loko o nā ʻāpana a hoʻonā i ka paona o ke kino o ka mea maʻi.

ʻO Glibenclamide kahi derivative o ka olakūluna he 2-hanauna. Ke hoʻohaʻahaʻa nei ia i ke kō ma muli o ka mea i hoʻoulu ʻia e ka huna kino ʻana o ka insulin i ka pancreas. I ka manawa like, ʻo kona hoʻopaʻa ʻana i nā pūleo e lilo i ʻoi aku ka maikaʻi, pale ʻia ka lipolysis ma nā pā adipose.

Hoʻopili kēia mau mea i kēlā me kēia kūpono, a ma muli o ka hopena i ka hopena o ka hopena hypoglycemic o ka lāʻau lapaʻau ma ke kino. E pale aku i ke kua o kona intake, ua hoʻomoʻa maikaʻi ʻia ka glucose i ka maikaʻi a me ka wikiwiki.

Lapaʻau lāʻau

Kahi hopena ʻike ʻia i loko o 2 mau hola ma hope o ka lawe ʻana iā Metglib, ʻo ka lōʻihi o ka hana o nā papa ma ke aniani hapalua i kēlā me kēia lā.I ka manawa like, hoʻopili ʻia ka glibenclamide e nā sela ma ka ʻōpū o ka gastrointestinal, ua hoʻouka ʻia i ka ate me ka huakaʻi aʻai a hoʻoulu ʻia e nā ʻōpū a me ka bile, a me ka metformin, hoʻopili ʻia hoʻi i loko o ka gastrointestinal tract, kānana nui ʻia e nā keiki me ka hele mau. ʻO ke kaʻina hana o ka glibenclamide he 4-11 hola, metformin - 6.5.

No ka poʻe e ʻeha nei i ka maʻi type type 2, i hāʻawi ʻia i ka mālama ʻana me ka ʻole o ka lāʻau (ʻai a me ka hana ʻana) ʻaʻole i uku ʻia.

Nā ʻōkuhi no ka hoʻohana (dosage)

Hoʻonohonoho ʻia ka komo ʻana e ke kauka hoʻokahi, e pili ana i nā hopena o nā hōʻike. Lawe ʻia ka lāʻau lāʻau me ka meaʻai. I kēia hihia, pono e hahai pono i ka ʻai nui i hoʻomaʻamaʻa maikaʻi ʻia nā mea.

Hoʻomaka ka mālamaʻana i ka 1 ʻĀina (2.5 mg a me 500 mg), a laila ma kēlā me kēia pule me ka nānā ʻana i nā pae glucose, ua hoʻoponopono ʻia ka dosage.

Inā hoʻohana ʻia nā mea ikaika o Metglib e nā mea maʻi ma ke ʻano o ka hoʻomākaukau ʻokoʻa, he mea nui loa ia e noʻonoʻo pono i kēia ke kau ʻana i kēia lāʻau lapaʻau paʻakikī, i kēia manawa me nā mea ikaika a pau i ka manawa.

Hōʻailona: ʻO ka nui loa o nā papa i kēlā me kēia lā he 4 (2,5 mg a i ʻole 5 mg a me 500 mg). Ke hiki i kēia helu ke alakaʻi i kahi overdose.

Hoʻohui nūhou

ʻAʻole hiki iā ʻoe ke lawe i ka miconazole me Metglib. Hiki i kēia i kahi coma.

Me ka hoʻolauna ʻana o nā iodine e hoʻopuni ai iodine e pale ai i nā pilikia me ka hana renal impaired, ua hoʻopau ʻia ka hoʻokipa ʻelua lā ma mua o ke kaʻina hana a hoʻomau wale ʻia ma hope o ke ʻano loiloi ma hope o 48 mau hola.

ʻAʻohe pilina me ka ethanol, phenylbutazone, bosentan ʻaʻole ʻia. Hoʻopili lākou i ka hopena o Metglib a hiki ke alakaʻi i ka hopena makemake ʻole.

Eia kekahi, ʻaʻole lākou e ʻōlelo e pili i ka hoʻohālikelike ʻana me ka mālama nui:

• beta adrenostimulants,
• Nālailax
• kekahaka
• hoʻoiho
• ACE inhibitors a me MAO,
• anticoagulants
• danazol
• desmopressin a me kekahi mau lāʻau lapaʻau.

I ka launa pū, hiki iā lākou ke hōʻeha i ka hypo- a i ka hyperglycemia a hōʻemi i ka hopena o kēlā me kēia.

E hoʻokuʻu i ke ʻano a me ka ʻano

Hoʻomoe ʻia ka lāʻau lapaʻau i ke ʻano o nā papa kiʻi ʻoniʻoni kiʻi: puni, biconvex, brown-brown i ka waihoʻoluʻu, ʻokoʻa ke keʻokeʻo ma ka ʻāpana ʻao (10 kēlā me kēia kīhāpiha blister, i loko o kahi pūpū pepa o 1, 2, 3, 4, 6, a i ʻole 9 mau pā. , 15 mau pcs i ka pōkoki palupula palaka, ma kahi pā kāleka o 2, 4 a i ʻole 6 mau pā, ua loaʻa nō hoʻi kēlā me kēia pā i nā kauoha no ka hoʻohana ʻana iā Metglib).

Pākaukau 1 papa:

• nā mea ikaika: metformin hydrochloride - 400 mg, glibenclamide - 2,5 mg,
• Nā kumuwaiwai hou: nā māka palaoa, macrogol (polyethylene glycol 6000), kalsiuma hydrogen phosphate dihydrate, sodium stearyl fumarate, sodium croscarmellose, microcrystalline cellulose, povidone,
• film sheath: Opadry honi ʻula (hydroxypropyl cellulose), hypromellose (hydroxypropyl methyl cellulose), titanium dioxide, talc, dye iron oxide melemele a me ka oxide ʻulaʻula.

Metglib, nā ʻōlelo e hoʻohana ai: ke ʻano a me ka helu ʻana

Lawe ʻia nā papa metglib.

ʻO ka makeʻana o ka lāʻau lapaʻau, ke ʻano o ka hoʻohana a me ka lōʻihi o ka lāʻau e hoʻoholo ai e ke kauka hele ʻana e noʻonoʻo ana i ka kūlana o ka pau aʻe o nā pakanā a me ke ʻano o ka glucose i ka glucose.

I ka nui o nā hihia, ua lawe ʻia ʻo Metglib i kahi la mua o kēlā me kēia lā o 1-2 papa, me kahi kīʻaha nui. I ka wā e hiki mai ana, e lawe ʻia ana kahi hoʻoponopono lohi e hiki ke hoʻokō i ka hopena e pono ai, hiki ke hāʻawi ʻia i kahi normalization o nā nui glucose koko. I kēia hihia, ʻaʻole pono e piʻi ka nui o ka uku i kēlā me kēia lā i nā papa 6, hoʻokaʻawale ʻia i ʻekolu mau puʻupuʻu.

ʻŌpū a me ka lactation

ʻAʻole kuhi ʻia nā wahine hāpai e lawe iā Metglib. I ka wā o ka mālama ʻana, pono e hōʻike ʻia ke kauka hele i ka wahine i hoʻolālā ʻia a i ʻole ma ka hoʻomaka ʻana, ʻoiai ʻo ia mau hana he mea pono e hooki i ka lawe ʻana i ka lāʻau lapaʻau a hoʻoneʻe i ka mea maʻi i ka insulin.

I ka wā ʻānai ʻia, ua contraindicated ke hoʻohana ʻana o Metglib, no ka hemahema o ka ʻike e pili ana i kona hiki ke hoʻopā ʻia i ka waiū kanaka. Inā makemake ʻoe e lawe i ka lāʻau lapaʻau i ka wā lactation, pono ʻoe e ho'ōki i ka hōʻuluʻulu ʻana a hoʻololi paha i ka therapy insulin.

ʻO ka lāʻau lapaʻau Metglib no ka maʻi maʻi

ʻO ka Metglib kahi lāʻau lapaʻau hoʻohui hoʻohui me ka hopena hypoglycemic, i hoʻolālāʻia e kāohi i ka maʻi diabetes 2 ʻano. Hoʻomaopopo ka lāʻau antidiabetic o ka lāʻau o ka koho mua e ʻelua mau ʻano lāʻau me ke ʻano hoʻohui o ka hana, e hiki ai i ka mana ikaika o ka metabolism ka insulin a me ka glucagon. Hoʻohana ʻia ka lāʻau lapaʻau no ka poʻe maʻi maʻi e hui pū me ka lawe ʻana i nā pills me ka insulin: e hōʻemi ana lākou i ka huehue a me ka helu o nā inikini hormone.

ʻOiaʻiʻo, ʻaʻole kūpono ke hoʻohana ʻia i nā hihia a pau (e like me kekahi lāʻau lapaʻau hypoglycemic), akā pili pololei ʻo Metglib me nā mana o kēia wā o ka pilina a me ka maikaʻi.

ʻO ka hiʻohiʻona o ka lāʻau lapaʻau

A hoʻāʻo ʻia ka noʻonoʻo maikaʻi maikaʻi a i nā maʻi neʻe o ka hana ʻelua - metformin (400-500 mg) a me ka glibenclamide (2.5 mg) hiki ʻole ke hoʻomohala piha a hoʻomohala piha i ka ʻike glycemic, akā hiki nō iā ia ke hōʻemi i ka pae ʻana o nā mea kanu.

Ke hoʻohana ʻia kēlā me kēia lāʻau lapaʻau maʻamau i ka monotherapy, ʻokoʻa loa kā lākou dosis. Hoʻohui kekahi i nā mea maʻamau, loaʻa pū nā hoʻopiha hou pū kekahi me ka cellulose, starch, gelatin, glycerin, talc a me nā mea hoʻohui'ē aʻe. Loaʻa i nā papa Metglib Force i loaʻa i kahi kaila o 5 mg glibenclamide a me 500 mg metformin.

Hiki ke hoʻomaopopo ʻia ka lāʻau lapaʻau paʻakikī e nā hōʻailona aʻe: nā papa oval i ka pale malū o ka terracotta a i ʻole ke waiho ʻulaʻula keʻokeʻo me ka laina hoʻokaʻawale ʻia i loko o nā ʻāpana poloka o nā 10 - 90 mau ʻāpana. Hoʻopili ʻia nā poli me nā kauoha ma kahi pahu pahu. Ma ke kumu kūʻai kūpono Metglib: 240-360 mau rubles. no ka pahee.

Lapaʻau Metglib

ʻO ka mea kumu mua o ka hopena i ʻike ʻia ka hapanui o nā maʻi me ka maʻi 2 e like me ka metformin, ʻo ia wale nō ke ʻano o kāna ʻano i ka pūʻulu biguanide e hōʻemi ana i ka pale ʻana o nā ʻenekelene i hoʻopau ʻia i ka insulin endogenous. ʻOi aku ka maikaʻi o ka hoʻololi ʻana ma mua o ka hoʻoulu ʻana o kāna huahana, ʻoiai i ka maʻi diabetes type 2, nā β-cells e hāʻawi i ka nui o ka hana.

Ma kahi o ka hoʻomaikaʻi ʻana i ka pono o ka postreceptor insulin, ʻo ia hoʻi ka pono o ka māhele.

• Hoʻopili i ka hoʻopili ʻana o ka glucose i nā pā o ka puʻuwai, hoʻoulu ʻia i kona hoʻohana e nā ʻili,
• Nā hōʻikeʻike o ka gluconeogenesis,
• Protection-cell-protection against preature apaptosis and necrosis,
• ʻO ka pale ʻana i nā ʻano āpau āpau a me nā maʻi ʻino loa
• ʻO ka hoʻokūkū o ka microcirculation o nā wai ola, nā hana endothelial a me nā metabol ka lipid,
• Ka hoʻohaʻahaʻa i ka hoʻokaʻawale koko, ke kāohi ʻana i ke kaumaha o ka oxidative, hoʻomaikaʻi i ka hui lipid koko.

ʻO ke kūlana koʻikoʻi no ka maʻamau o ka hoʻopili ʻana o ka lipid type i ke ʻano type diabetes 2. Kōkua ʻo Metformin i ka pale ʻana i ka maʻi hānai. ^ E Ha yM. Ma kahi maʻi hōʻeha e hoʻonui ai i nā maʻi o nā maʻi maʻi o ka hōʻemi i ka 40%. Hoʻopiliʻo Biagunide i nā loli loli. ʻOi aku no nā poʻe olakino ma mua o 40, ʻōlelo ʻo WHO e lawe iā Metformin i ka palena haʻahaʻa loa no ka pale ʻana i ka wā kahiko a me nā hanana cardiovascular.

ʻO ka mea kanu manamana ʻelua, ʻo ia ka glibenclamide, he ʻelele o ka hui hou ʻana o ka lāʻau sulfonylurea.

Hoʻokomo ʻia ka lāʻau lapaʻau i ka papa inoa o nā lāʻau ola nui me nā hopena pancreatic a me nā extrapancreatic effects.

Ke hoʻouluʻana i ka pancreas, hoʻonui ka mea hoʻomehana i ka hana o kāna iho insulin. E pili ana i nā kuleana cells-kuleana no ka holomua o ka maʻi diabetes type 2, he kūleʻa ka glibenclamide a mālama i kā lākou hana ma o ka hoʻoulu ʻana i nā mea hopu o nā cell target i he insensitive insulin.

He maikaʻi ka lāʻau lapaʻau i nā manawa āpau o ka hoʻomohala ʻana i ka maʻi maʻi, no ka mea, e hāʻawi ana i ka hopena multivariate:

• Pancreatic - hoʻonui i ka ʻike o nā ʻenehana target, pale i nā seleka β mai nā glucose kūwaho, e hoʻoulu ai i ka synthesis o ka insulin,
• ʻO ka extra-pancreatic - hana pololei ka metabolite me nā māhā a me nā ʻalā momona, pale i ka glucogenesis, a hiki i ka glucose ke hoʻopili piha.

ʻO ka hapa kūpono o nā mea kanu o ka ʻaʻoma e ʻae iā ʻoe e hoʻoponopono i ke ʻano ma ka liʻiliʻi, hoʻonui i ka palekana o ka lāʻau lapaʻau, e hōʻemi ana i ka hōʻemi o nā ʻaoʻao a me nā hana kūpono.

ʻLoe a me ke kākele

Ke koho nei i kahi mahele, ke kau nei ke kauka i nā hopena o nā hōʻike, ke ʻano o ka maʻi, nā pathologies pili, nā makahiki o ka maʻi maʻi a me ka pane ʻana aku o ke kino i nā mea o ka lāʻau lapaʻau.

No ka Metglib Force, e like me nā kauoha no ka hoʻohana ʻana, ʻo ka nui o ka lā mua ma mua o 2.5 / 500 mg a i ʻole 5/500 mg hoʻokahi. Inā lilo kekahi o nā ʻāpana Metglib a i ʻole nā ​​analogues o ke kaʻina sulfonylurea i hoʻohanaʻia ma ke ʻano he lāʻau mua, a laila i ka wā e hoʻohuli ai i ka lāʻau me ka hoʻohui pū ʻana, e alakaʻi ʻia ana lākou e ka dosage o nā papa mua.

Pono ka hoʻohaʻahaʻa ʻana i ka titration: ma hope o 2 mau hebedoma, hiki ke loiloi ʻia ka hoʻololi pono ʻana o ka lāʻau therapeutic mua a hoʻoponopono ʻia i 5/500 mg. Ma nā kikowaena o ka hapalua mahina, inā pono, hiki ke hoʻonui ʻia i ke ʻano ma nā papa 4 i ka make ma ka 5/500 mg a i ʻole nā ​​papa 6 me kahi maʻi o 2.5 / 500 mg. No ka Metglib me kahi pākaukau o 2.5 / 500 mg, ʻo ka nui loa he 2 mg o ka lāʻau.

Hoʻolako maikaʻi ʻia ka papa inoa dosage ma ka papa ʻaina.

No nā maʻi maʻi maʻi me ka liʻiliʻi o ka hiki ʻana i nā puʻupuʻu liʻiliʻi, ua kuhikuhi mua ʻia ka nui o ka lāʻau o ka Metglib Force me ka 2.5 / 500 mg. I kēia hihia, pono e nānā mau ʻia ke kūlana o ka ʻōpū, ʻo ka hōʻuluʻulu ʻana o ka metformin i kona wā hoʻopau ʻole he mea paʻakikī ia, akā he hoʻopiʻi koʻikoʻi - kahi lactic acidosis. Me ka hoʻoikaika kino kino loa a me ka ʻai kīnā ʻole, ua like nā palena.

ʻO nā hopena hemo, overdose

ʻAʻole nā ​​kumu i ke kumu e hōʻole i ka mālama ʻana: ma hope o ke ʻano o ke kino, hele a nui nā hōʻailona like me lākou iho, a ʻoi aku ka nui o ka hōʻeha ʻana mai ka maʻi maʻi ʻole e ʻike ʻia ma mua o ka hopena e hiki mai ana ma Metglib. ʻO ka mea nui ka helu pololei ʻana i ka dosage: me ka loaʻa ʻole ʻana a i ʻole make ʻole i hoʻolālā ʻia, hoʻomohala ʻia i kahi maʻi maʻi ʻona e makemake ai ka wolf, nalowale ka ikaika, hopohopo nā lima, lulu nā lima. Pehu a ua keʻokeʻo ka paʻu, wikiwiki ka ʻōpū o ka puʻuwai, kokoke i nā mea palupalu. No ka loaʻa ʻana o ka hypoglycemia i ʻoi aku ka poʻe no ka poʻe ʻelemakule a nawaliwali i ka maʻi maʻi a me ka hypocaloric i kūlohelo i nā maʻi maʻi.

Ma ke ʻano o ka overdose, ua nānā ʻia kēlā penei:

• ʻEha ka ʻōpū
• Migraines
• Nā maʻi Dyspeptic
• Nā ʻano like ʻole o ke ʻano maʻi.

Hoʻokuʻu ʻia ka ʻoluʻolu hōʻoluʻolu kino i ka wā maʻi, ka hōʻike mau ʻana i nā hōʻailona e pono ai nā mea hou aku me nā mea hoʻohālike Metglib – Diabeton, Dimaril, Gluconorm, Bagomet Plus, Glukovans, Glibenclamide i hui pū me Metformin, Glucofast (ma ka ʻaha o ke kauka).

Na maʻi maʻi e pili ana i ka Metglieb

Ma nā papa kūkala kūkākūkā ma Metglib, ua hui pū ʻia nā loiloi o nā maʻi maʻi a me nā kauka, no ka mea ke hoʻomehana nei ka hapa nui o ka maʻi maʻi, a he mea paʻakikī iā lākou e loiloi i ka hana pono o kekahi lāʻau lapaʻau ponoʻī. ʻO nā ʻikepili hou aku e pili ana i ka regimen mālama: ʻo nā mea āu i koho ai i ke kūleʻa ke koho pololei ʻole i nā hopena ʻokoʻa. Akā ʻo ka hoʻāʻo ʻana i ka ʻike ma kahi maʻi maʻi maʻamau ʻaʻole i kūpono a hiki ʻole ke weliweli.

I ka hōʻuluʻuluʻana i nā manaʻo āpau, hiki iā mākou ke manaʻo i ka Metglib no ka monotherapy o ke ʻano maʻi type 2 ʻo ke ala maikaʻi loa: kahi palekana palekana palekana a me ka hopena kūpono, ke kumukūʻai kūpono, hopena maikaʻi i ke kaumaha o ka mea maʻi, pale i nā pilikia cardiovascular a me ka oncological e waiho i ka lāʻau lapaʻau i kahi lā hanohano o nā lāʻau lapaʻau mua-koho.

Hoʻohālikelike me nā lāʻau lapaʻau like

He loaʻa nā Metglib i nā heluʻikepili e pono e familiarize iā ʻoe iho me.

Kūkākūkā. ʻO ka mea momona e metformin a me glibenclamide.

Uka - 250 rubles i kēlā me kēia pā.

Mea Hana - Merck Sante SAAS, Farani.

Hoʻokomo: ʻo ka hopena o ka mālama ʻana me ka Metglib, no laila ke kuhikuhi ʻia inā ʻaʻole pono kēia lāʻau lapaʻau i ka mea maʻi.

Cons: kahiʻuʻuku hou aku, nā contraindications like a me nā hopena ʻaoʻao.

Hoʻolauleʻa. Mea waiwai kūlike: like.

Kumukūʻai - kahi awelika o 240 mau rubles i 30 mau ʻāpana.

Mea Hana - MJ Biofarm, India.

Kālau - hoʻohaʻahaʻa i ka hoʻokahe koko.

ʻO nā pros: kūpono no ka hapanui o nā maʻi, kūpono.

Cons: aia nō hoʻi he nui nā contraindications, ʻoi aku ke kumu ʻoi aku.

Hoʻopili ʻia kekahi o ka lālani lāʻau me kahi ʻē aʻe e like me ka mea i kuhikuhi ʻia e ke kauka. Ua papa ʻia ka lāʻau lapaʻau pilikino!

Nui nā manaʻo e pili ana i kēia mau lāʻau. No kekahi, ua kūpono kūpono ka lāʻau lapaʻau, no nā mea'ē aʻe - ʻaʻohe, e nānā ka nui o nā mea ʻē aʻe. Akā ka hapanui, ʻo nā loiloi maikaʻi e ʻoi aku ka maikaʻi.

Vera: "Ma ka manawa mua ua hoʻohana lākou iā Glibomet, akā i kēia manawa ua piʻi ke kumukūʻai. Ua noi au i ke kauka e kākau i kahi mea ʻoi aku ka maʻalahi, akā ʻo ia nō hoʻi ke hana. No laila, loaʻa iaʻu kahi hoʻolālā no Metglib. ʻOi ke kumukūʻai nui loa, e hoʻemi ana i ke kōpaʻa ʻoiai ma ke ʻano o ka ʻai ʻana. Akā, pono wau e kauoha i loko o ka haleʻaʻai i mua - no kekahi mau kumu, ua hoʻokomo maikaʻi ʻia. ʻO ka mea nui, ʻaʻohe hopena hopena, a ʻo ke koena ke trifles. "

Dmitry: "Ua kuhikuhi mai ke kauka iaʻu Metglib i ka wā i hōʻike ai lākou i ka maʻi maʻi 2. Lawe wau i kēia lāʻau lapaʻau no kahi mahina hoʻokahi mahina, ʻaʻole ʻike i kahi hopena kūikawā. Ua hōʻemi iki ʻia ka Sugar, a no laila ua hoʻoili ʻia i kekahi lāʻau lapaʻau ʻē aʻe. Akā, lohe au mai nā hoaaloha ua kōkua ʻo ia i kekahi. "

Denis: “Ua inu au i ka Metglib no 2 mau pule, ua pōkole ka hanu. Hele wau i ke kauka, hoʻouna ʻo ia no ka hoʻokolokolo. A ke hopena, hoʻoponopono mākou i ka nui a me ke ana. Ano ea na mea apau. Ua hana ʻia ka Sugar no 2 mau mahina, no laila ua hauʻoli wau i ka lāʻau lapaʻau. ”

Me ka hana pūnāwai paʻa ʻole

I ka poʻe maʻi me ka hana ʻōmaʻomaʻo i ʻole ke ahonui, ua hōʻemi ʻia ka hoʻomaʻemaʻe kino o ka metformin, e like me QC, akā naʻe, T_1/2 e hoʻonui ia, ka mea e alakaʻi ai i ka hoʻonui i ke kiʻekiʻe o ka mika o ka metformin i ke koko. Hoʻopili ka mana ʻo Metglib i nā maʻi me ka hiki ʻole o ka hana ʻole a i ʻole ke kau ʻana o nā maʻi ma o ka pēpē, ʻo ka CC coefficient o nei e haʻahaʻa ma lalo o 60 ml / min.

Ma muli o ka mea i hoʻopili ʻia ai ka metformin e nā keiki, ma mua o ka hoʻomaka ʻana o ka papa o ka lapaʻau a me ka hana pinepine i ka wā ʻo ka lapaʻau ʻana me Metglib, pono ia e hoʻokū i ka QC a me / a pae serum bun i loko o ke koko. I ka poʻe maʻi me ka hana maʻamau maʻamau, hōʻike ʻia nā hōʻike ʻana ma kahi o ka manawa 1 ma kēlā me kēia makahiki. I ka poʻe elemakule a i ʻole nā ​​maʻi me CC, e hōʻea i ka palena kiʻekiʻe o ka maʻamau - 2-4 mau manawa i ka makahiki. ʻO ka mālama kūikawā e mālama ʻia i kahi pilikia o ka hiki ke hana ʻole i ka hana renal, no ka mea, i ka poʻe maʻi ma waena a i ka hoʻomaka ʻana o ka lāʻau antihypertensive concomitant, i ka wā e hoʻohana ai i ka diuretics a i ʻole nā ​​lāʻau lapaʻau anti-inflammatory a (NSAIDs).

Hoike e pili ana iā Metglieb

Ma nā pūnaewele lapaʻau kūikawā, haʻalele nā ​​mea maʻi i nā loiloi maikaʻi a maikaʻi ʻole hoʻi e pili ana iā Metglib. ʻO ka hapa nui o lākou ka nota me ka hopena o ka therapeutic dosages, ua loaʻa ke hopena hopena maikaʻi. Eia nō naʻe, ma muli o ka loaʻa ʻana o nā maʻi me ka maʻi mellitus i kēia lā lāʻau i ka hui pū ʻana me nā lāʻau lapaʻau hypoglycemic ʻē aʻe, ʻaʻole hiki iā lākou ke hāʻawi i kahi loiloi pahuhopu i ka hopena o ka maikaʻi o Metglib. ʻO nā maʻi āpau a me nā maʻi diabetes e ʻokahi pū i hoʻokahi mea - i ka wā o ka mālama ʻana i kēia maʻi, pono ke kauka ke kau i ka ʻōpū, ʻo nā kauka hele wale nō e kau i ka dosis a me ka hoʻoponopono.

Hoʻomaopopo pinepine nā hemahema i kahi papa inoa o nā contraindications a me nā hopena ʻino. ʻO ka kumu kūʻai o Metglib ua kapa ʻia ʻo ia ka mea hiki.