Hoʻololi ka hopena o ka fraxiparin

I kēiaʻatikala, hiki iā ʻoe ke heluhelu i nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau Fraxiparin. ^ E Ha yM. Hāʻawi i ka manaʻo o ka poʻe kipa i ka pūnaewele - nā mea kūʻai o kēia lāʻau lapaʻau, me nā manaʻo o nā loea lapaʻau e pili ana i ka hoʻohana ʻana iā Fraxiparin i kā lākou hoʻomaʻamaʻa. ʻO kahi noi nui, ʻo ia ke hoʻoikaika ikaika i kāu mau loiloi e pili ana i ka lāʻau lapaʻau: kōkua ka lāʻau lapaʻau a ʻaʻole hoʻi i kōkua i ka hoʻopiʻi ʻana i ka maʻi, nā mea hoʻopiʻi a me nā hopena ʻaoʻao, ua ʻike ʻia, ʻaʻole i hoʻolaha ʻia e ka mea hana ma ka annotation. Nā kikowaena o Fraxiparin ma ke alo o nā mea hoʻokolohua i loaʻa i nā mana. Hoʻohana no ka mālama ʻana a me ka pale ʻana i ka thrombosis a me ka thromboembolism i nā pākeke, nā keiki, me ka wā hāpai a me ka lactation.

Fraxiparin - he haʻahaʻa kaumaha heparin (NMH) i loaʻa ma ka depolymerization mai ka heparin maʻamau, he glycosaminoglycan me ke kaumaha o ka molekole pānaʻi o 4300 daltons.

Hōʻike i kahi hiki nui ke hiki i ka protein plasma me ka antithrombin 3 (AT 3). Hoʻopuka kēia pākuhi i ka wikiwiki o ka hoʻololi ʻana i ke kumu 10a, nona ka waihona kiʻekiʻe antithrombotic kiʻekiʻe o ka nadroparin (ka mea ola o ka lāʻau Fraxiparin).

ʻO nā hana ʻē aʻe e hāʻawi ana i ka hopena antithrombotic o ka nadroparin me ka hoʻihoʻi ʻana i ka hoʻoweliweli ʻōiwi kiko (TFPI), hoʻōla o ka fibrinolysis ma ka hoʻokuʻu ʻana i kahi kiko o ka plasminogen aine mai nā cell endothelial, a me ka hoʻololi ʻia o ka waiwai rheological o ke koko (hoʻohaʻahaʻa i ka hoʻokahe ʻia o ke koko a me ka hoʻonui ʻana i ka permeability o platelet a me nā granulocyte membranes).

Hōʻike ʻia ka calciumium nadroparin e ka mea ʻoi aku ka kiʻekiʻe anti-10a i hoʻohālikelike ʻia i ka hana anti-2a a i ʻole ka hana antithrombotic a loaʻa a ʻoi aku ka hana antithrombotic hana a lōʻihi.

Hoʻohālikelike me ka heparin unfractionated, ua loaʻa ka nadroparin i ka hopena pākahi ma ka platelet function a me ka hōʻuluʻulu ʻana, a me kahi hopena i emi ʻole i ka hemostasis mua.

I nā pilala prophylactic, ʻaʻole Fraxiparin i kahi i hoʻemi ʻia i APTT.

Me ka papa o ka mālama ʻia i ka wā o ka hana nui, hiki i ke hoʻonuiʻana i ka APTT i kahi kumukūʻai 1.4 mau manawa ma mua o ka maʻamau. Hōʻike kēia mau lōʻihi i ka hopena antithrombotic residual o ka calcium nadroparin.

Hōʻike

Kaleponi nadroparin + mea loaʻa.

Lapaʻau lāʻau

Hoʻoholo ʻia nā waiwai Pharmacokinetic ma nā kumu o nā loli i ka hana anti-10a.

Hoʻololi loa ka Fraxiparin i kahi kokoke loa (e pili ana i ka 88%). Me ka hoʻokele intravenous, ua loaʻa i ka hana anti-10a kiʻekiʻe ma kahi o 10 mau minuke. Hoʻomili ʻia ka mea nui i ka ate ma ka desulfation a me ka depolymerization.

Ua hōʻike nā hualoaʻa o ka noi ʻana i hiki ke ʻike ʻia i kahi hōʻiliʻili liʻiliʻi o ka nadroparin i nā mea maʻi me nā maʻi renal a me ke kaulike (CC ≥ 30 ml / min a

Nā ʻōkuhi no ka hoʻohana a me ka helu ʻana

Pehea a ma hea e wailua ai i Fraxiparin - kaila injection

Me ka hoʻokele subcutaneous, ʻoi aku ka maikaʻi o ka lāʻau i ka kūlana kiʻekiʻe o ka mea maʻi, i ka kiko subutanutan o ka anterolateral a i ʻole posterolateral luna o ka ʻōpū, i ʻole ka ʻaoʻao ma ka ʻaoʻao hema a hema. Hāʻawi ʻia e komo i ka ʻōpū.

I mea e pale ai i ka nalowale ʻana o ka lāʻau ke hoʻohana ʻana i nā syringes, ʻaʻole pono e haʻalele i nā leʻe o ka lewa ma mua o ka huakaʻi.

E hoʻokomo pono ʻia ka pono me ka wili ʻana, a ʻaʻole ma ke kihi, i loko o ka paila i hoʻopili ʻia ma waena o ka manamana lima a me ka mua. Pono ka mālama i ka wā o ka mālama o ka lāʻau. Mai ʻūleʻa i ka pūnaewele inake ma hope o ke ahulau.

No ka pale ʻana i ka thromboembolism ma ka hana hoʻomaʻamaʻa maʻamau, ʻo ke ʻano o Fraxiparin i ʻōlelo ʻia ʻia ʻo 0.3 ml (2850 anti-10a ME) s / c. Hoʻohanaʻia ka lāʻau no 2-4 mau hola ma mua o ka hana ʻana, a laila - 1 manawa i kēlā me kēia lā. Hoʻomau ʻia ka mālama ʻana no ka liʻiliʻi o 7 mau lā a i loko o ka manawa holoʻokoʻa o ka mahuahua o ka thrombosis, a hiki i ka mea maʻi ke neʻe aku i kahi pae maʻi maʻi.

I mea e pale ai i ka thromboembolism i ka wā o nā hana orthopedic, mālama ʻia ʻo Fraxiparin ma ka subcutaneously ma kahi la i hoʻoholo ʻia e like me ke kaumaha o ke kanaka maʻi ma ka pae o 38 anti-10a IU / kg, hiki ke hoʻonui ʻia i 50% ma ka lā 4 o ka wā ʻoihana. Ua kuhikuhi ʻia ke ʻano ma mua o 12 mau hola ma mua o ka hana ʻana, ka lua o ka lua - 12 mau hola ma hope o ka pau o ka hana. Eia kekahi, hoʻomau ʻia ka Fraxiparin i hoʻokahi manawa i ka lā i ka manawa holoʻokoʻa o ka nui o ka nui o ka hiki ʻana i ka thrombosis a hiki i ka mea maʻi ke hoʻoneʻe i kahi maʻi outpatient. ʻO ka palena iki o ka mālamaʻana he 10 mau lā.

I ka loaʻa ʻana o ka angina pectoris unstable a me myocardial infarction me ka hawewe Q, ua kau ʻia ʻo Fraxiparin sc 2 mau manawa i kēlā me kēia (kēlā me kēia hola 12). ʻO ka lōʻihi ka mea mālama i ka 6 mau lā. Ma nā haʻawina loiloi, nā maʻi me ka stina manuahi hiki ʻole i ka fina me ka hala o Q wave Fraxiparin i kuhikuhi pū ʻia me ka acetylsalicylic acid ma kahi o 325 mg i kēlā me kēia lā.

E mālama ʻia ka ʻōlelo mua ma ke ʻano he hoʻokahi intravenous bolus injection, ua lawelawe ʻia ʻo nā maʻi he subcutaneously. Kau ka paena ma muli o ke kaupaona ʻana o ke kino ma ka wikiwiki o 86 anti-10a IU / kg.

I ka loaʻa ʻana o ka thromboembolism, ʻōlelo anticoagulants waha (i ka ʻole o contraindications) e kuhikuhi koke i ka manawa. ʻAʻole paʻa ka Therapy me Fraxiparin a hiki i ka loaʻa ʻana o nā waiwai kumu o ka hōʻailona manawa prothrombin. Ua ʻōlelo ʻia ka lāʻau lapaʻau s / c 2 mau manawa i kēlā lā (i kēlā me kēia mau hola 12), ʻo ka manawa maʻamau o ka papa he 10 lā. Kūpono ʻia ka pākuhi ma ke kaumaha o ke kino o ka mea maʻi ma luna o 86 anti-10a IU / kg kau kino.

Loaʻa ka hopena

• ka huhū ʻana o nā ʻano kuahiwi,
• thrombocytopenia
• eosinophilia, hiki ke hoʻololi ʻia ma hope o ka hoʻokuʻu ʻana o ka lāʻau lapaʻau,
• hypersensitivity mau maʻi (Quincke's edema, ʻano lole),
• ka hoʻokumu ʻana o kahi hematoma subcutaneous liʻiliʻi ma ka wahi i ʻōlelo ʻia,
• nā ʻōpū ʻōpiopio o ka ʻili, ma ka manawa kūpono no ka pūnaewele.
• priapism
• hyperkalemia hoʻi hoʻohuli (i pili me ka hiki o nā heparins e hoʻomau i ka huna ʻana o ald testosterone, keu i ka poʻe maʻi ma ka hopena).

Nā Hoʻohui

• thrombocytopenia me ka mōʻaukala nadroparin,
• nā hōʻailona o ke kahe a he piʻi nui paha o ke koko e pili ana i ka hemostasis impaired (me ka ʻokoʻa ʻole o DIC ʻaʻole i kumu ʻia e heparin).
• Meaʻino kino kino me ka makemake i ke kahe (no ka laʻana, he ulia ʻōpū a me nā ʻōpio duodenal),
• nā hōʻeha a me nā hōʻuluʻulu ʻana ma ka lolo a me nā kaula spinal a i ʻole nā ​​maka,
• ʻōpū kikipopa,
• endocarditis septic kaulike,
• pilikia hōʻeha nui (CC

Nā kuʻina o ka lāʻau Fraxiparin

Ua ʻoi aku ka uku o ka analogue mai ka 2164 mau rubles.

ʻO Wessel Douay F he anticoagulant hana pololei i hoʻokumu ʻia i ka sulodexide i loko o kahi papa o 250 LE. Hiki ke hoʻohālikelike ʻia no ka mālama ʻana i ka ulia cerebrovascular, dementia vascular, thrombosis vein hohonu a me nā maʻi ʻē aʻe.

Ua ʻoi aku ka uku o ka analogue mai ka 527 mau rubles.

Mea Hana: ʻO Sanofi Winthrop Industry (Palani)
Kuhi puka:

• Syringe he 10 mano.ʻOhi-ChAME / ml 0.6 ml, 2 pcs., Kumukūʻai mai 826 mau rubles

ʻO Clexane kahi hana anticoagulant i ka hana a Farani. Loaʻa i ka ʻano o kahi hoʻonā i loaʻa ka sodium enoxaparin. Ua hoʻohālikelike ʻia he prophylactic no ka thrombosis venous, a no ka mālama ʻana i ka thrombosis vein hohonu. I ka wā hāpai a me ka lactation hiki ke kuhikuhi wale ʻia i nā hihia kūikawā.

Ua ʻoi aku ka uku o ka analogue mai ka 1428 mau rubles.

Anfibra kahi kikowaena ʻokoʻa o ka hoʻoili paʻahana hale. I kūʻai ʻia i loko o kahi pūpū o 10 ampoules, kēlā me kēia me ka sodium enoxaparin. Ma muli o nā ʻokoʻa i loko o ka mea i hoʻonohonoho ʻia, hiki ke hana i kahi mea hiki ke hoʻololi wale ma hope o ke koho ʻana i kahi kauka.

Ua ʻoi aku ka uku o ka analogue mai ka 1868 mau rubles.

ʻO Angioflux kahi lāʻau Lūkini mai ka launa lāʻau lapaʻau like. ʻOkoʻa ka ʻokoʻa ma Fragmin i ka hoʻoili ʻana, akā he ʻano kūlike kekahi. Hiki ke kuhikuhi i ka angiopathy, piʻi i ka nui o ka thrombosis, nā manawa mua o ka ischemia haʻahaʻa. Aia nā ʻokoʻa ma nā contraindications a me nā hopena ʻaoʻao.

Ua ʻoi aku ka uku o ka analogue mai ka 1256 rubles.

Mea Hana: Vetter Pharma-Fertigung GmbH (Kelemānia)
Kuhi puka:

• Syringe 2500 IU, 0.2 ml, 10 pcs., Kumukūʻai mai 1555 mau rubles

ʻO Fragmin kahi lāʻau Kelemania i hana ʻia ma ke ʻano o ka hoʻonā ʻana no ka hoʻokele intravenous a me ka subcutaneous. Hiki ke hoʻohālikelike ʻia no ka mālama ʻana i ka trombosis hohonu o ka vein a me ka embolism pulmonary, ka angina hiki ʻole a me ka infococial myocardial (me ka hawewe Q ma ka ECG), me ka pale ʻana ma ka maʻi thrombosis i ka wā hōʻālepa.

Ua ʻoi aku ka uku o ka analogue mai ka 1418 mau rubles.

ʻO Enixum kahi kahaki no Wessel Douay F anticoagulant kahi hana like. ʻO nā mea kūlike mai ke kumu i loko o ka mea kanu akt - enoxaparin sodium. Hoʻohana ʻia ka lāʻau i nā hana subcutaneously a i ʻole intravenously. ʻO ka palekana a me ka hiki ʻana o ke kuhikuhi ʻana i ka lāʻau lapaʻau i nā keiki ma lalo o 18 makahiki o ka makahiki ʻaʻole i aʻo ʻia ʻia.

ʻOi like ka analogi mai ka 134 mau rubles.

Mea Hana: Italfarmako S.p.A. (Italia)
Kuhi puka:

• Ke kaua nei 10 mano anti-Ha ME / ml 0.2 ml, 1 pc., Kumukūʻai mai 165 rubles

ʻO kahi huahana i hana ʻia ma Italia. Kuhi ʻia ia ma ke ʻano o kahi hopena no ka ʻākala kūlike a me ka sodium enoxaparin i nā dosages mai 2000 a 6000 IU e hoʻohana ʻia ma ʻaneʻi he mea hana ikaika. E like me nā hōʻike nui no ka koho ʻana, ua like ia me Clexane a ua ʻōlelo pū ʻia no ka thrombosis (hana a me ka pale ʻana).

Nā hōʻailona no ka hoʻohana ʻana

He aha ka mea e kōkua ai iā Fraxiparin? Wahi a nā ʻōlelo kuhikuhi, ua kuhikuhi ʻia ka lāʻau lapaʻau ma kēia mau hihia.

• ka pale ʻana o nā hoʻopiʻi thromboembolic i ka mahele o ka wawaʻi ʻana o ka ʻohi a ʻana paha.
• i nā mea maʻi me ka pilikia nui o ka hoʻopiʻi thromboembolic (ka hoʻopiʻi ʻana ʻana a me / a i ʻole nā ​​maʻi lēwa o ka ʻōpū o ka ʻōpū, a me / a i ʻole ka hōʻeha ʻana o ka naʻau) i mālama ʻia i ka maʻi mālama pilikino, e mālama ʻia ana i nā hoʻopiʻi thromboembolic,
• kaohi ʻana o ka hoʻomānoʻi koko ma ka hemodialysis, mālama ʻana i ka angina hiki ʻole a me ka infococio myocardial me ka ʻole o ka nalu Q ma kahi ECG.

Nā ʻōkuhi no ka hoʻohana ʻana iā Fraxiparin, dosage

Me ka hoʻokele subcutaneous, ʻoi aku ka maikaʻi o ka lāʻau i ka kūlana kiʻekiʻe o ka mea maʻi, i ka kiko subutanutan o ka anterolateral a i ʻole posterolateral luna o ka ʻōpū, i ʻole ka ʻaoʻao ma ka ʻaoʻao hema a hema. Hāʻawi ʻia e komo i ka ʻōpū.

I mea e pale ai i ka nalowale ʻana o ka lāʻau ke hoʻohana ʻana i nā syringes, ʻaʻole pono e haʻalele i nā leʻe o ka lewa ma mua o ka huakaʻi.

E hoʻokomo pono ʻia ka pono me ka wili ʻana, a ʻaʻole ma ke kihi, i loko o ka paila i hoʻopili ʻia ma waena o ka manamana lima a me ka mua. Pono ka mālama i ka wā o ka mālama o ka lāʻau. Mai ʻūleʻa i ka pūnaewele inake ma hope o ke ahulau.

• No ka pale ʻana i ka thromboembolism ma ka hana hoʻomaʻamaʻa maʻamau, ʻo ke ʻano o Fraxiparin i ʻōlelo ʻia ʻia ʻo 0.3 ml (2850 anti-Xa ME) s / c. Hoʻohanaʻia ka lāʻau no 2-4 mau hola ma mua o ka hana ʻana, a laila - 1 manawa i kēlā me kēia lā. Hoʻomau ʻia ka mālama ʻana no ka liʻiliʻi o 7 mau lā a i loko o ka manawa holoʻokoʻa o ka mahuahua o ka thrombosis, a hiki i ka mea maʻi ke neʻe aku i kahi pae maʻi maʻi.
• I mea e pale ai i ka thromboembolism i ka wā o nā hana orthopedic, mālama ʻia ʻo Fraxiparin ma ka subcutaneously ma kahi paona i kau ʻia ma ke ʻano o ke kino o ka mea maʻi ma ka pae o 38 anti-XA IU / kg, hiki ke hoʻonui ʻia i 50% ma ka lā 4 o ka wā o ka postoperative. Ua kuhikuhi ʻia ke ʻano ma mua o 12 mau hola ma mua o ka hana ʻana, ka lua o ka lua - 12 mau hola ma hope o ka pau o ka hana. Eia kekahi, hoʻomau ʻia ka Fraxiparin i hoʻokahi manawa i ka lā i ka manawa holoʻokoʻa o ka nui o ka nui o ka hiki ʻana i ka thrombosis a hiki i ka mea maʻi ke hoʻoneʻe i kahi maʻi outpatient. ʻO ka palena iki o ka mālamaʻana he 10 mau lā.
• ʻO ka poʻe maʻi me ka pilikia nui o ka thrombosis (maʻamau i loko o ka ʻina mālama mālama / ʻina hana mālama / ʻōpū a me ka ʻeha a me ka maʻi ʻana o ka ʻeha a me / a i ʻole hōʻeha o ka naʻau /) Ua kau ʻia ʻo Fraxiparin s / c 1 i kēlā me kēia lā i kahi lae i kau ʻia ma luna o ke kaumaha o ke kino. ka mea maʻi. E hoʻopili i ka manawa holoʻokoʻa o ka hopena o ka trombosis.
• I ka mālamaʻana i ka pectoris angina pectoris a me myocardial infarction me ka make ʻole Q, s / c i kuhikuhi ʻia 2 mau manawa i kēlā me kēia (i kēlā me kēia mau hola 12). ʻO ka lōʻihi ka mea mālama i ka 6 mau lā. Ma nā noiʻi haukapila, nā mea maʻi me ka angina pectoris / myocardial infarction ʻole me Q wave Fraxiparin i kuhikuhi pū ʻia me ka acetylsalicylic acid ma kahi o 325 mg / lā. Paʻi ʻia nā ʻōlelo no ka hoʻohana ʻana e mālama ʻia ka ʻōlelo mua ma ke ʻano he hoʻokahi kū hoʻokahi bolus i hoʻokahi intravenous, a laila e hāʻawi ʻia nā pupu ma hope o s.c. Kau ka paena ma muli o ke kaupaona ʻana o ke kino ma ka wikiwiki o 86 anti-XA IU / kg.
• I ka loaʻa ʻana o ka thromboembolism, ʻōlelo anticoagulants waha (i ka ʻole o contraindications) e kuhikuhi koke i ka manawa. ʻAʻole paʻa ka Therapy a hiki i ka loaʻa ʻana o nā waiwai kūpono o ka māka manawa prothrombin. Ua ʻōlelo ʻia ka lāʻau lapaʻau s / c 2 mau manawa i kēlā lā (i kēlā me kēia mau hola 12), ʻo ka manawa maʻamau o ka papa he 10 lā. Hoʻokomo ka dosis i ka paona kino o ka mea maʻi ma ka helu o 86 anti-XA ME / kg koʻikoʻi kino.

Nā ʻōlelo kikoʻī

Mai lana i ka lāʻau lapaʻau intramuscularly!

I nā maʻi me ka piʻi nui o ka huhū, hiki iā ʻoe ke hoʻohana i ka hapalua o ke ʻano o ka lāʻau i manaʻo ʻia.

Inā he lōʻihi ka lōʻihi o ka dialysis ma mua o 4 mau hola, e mālama ʻia paha nā pona liʻiliʻi o ka lāʻau.

I nā poʻe maʻi maʻi, ʻaʻole pono ka hoʻoponopono ʻana o ka inika (me ka ʻokoʻa o nā mea maʻi me ka hana pūpū o ka maʻi). Ma mua o ka hoʻomaka ʻana i ka mālama ʻana me Fraxiparin, ʻoi ʻia ia e nānā i nā māka hana hana lela.

I nā maʻi me ka hōʻemi a i ʻole kaulike ʻole renal (CC ≥ 30 ml / min a

3 review for "Fraxiparin"

Ma hope o ka cesarean hoʻomaka lākou e hana noʻu, ma ka lua o ka lā i hoʻomaka ai kahi alerio weliweli ma ka wahi i ʻōlelo ʻia, pono wau e hoʻopau - ʻaʻole ia e hōʻeha mai iaʻu

Ua hoʻoneʻe ʻia mai ia mai Kleksan, ʻoi aku ka maʻalahi e ʻā. ʻAʻole hiki iaʻu ke haʻi i ka hopena, no ka mea, ua maʻa wau i nā ho'āʻo ma hope o ka hoʻololi ʻana i clexane ... akā maikaʻi nā mea a pau.

Ua nīnau au i ke kauka clexane a i ʻole fraksiparin ʻoi aku ka maikaʻi o ka maikaʻi. Ua ʻōlelo ʻo ke kauka he fraksiparin maoli nō ia. ʻO ka liʻiliʻi ʻoi aku ka mea o ka hoʻohana ʻana i kēia lāʻau lapaʻau i nā wahine hāpai i ʻoi aku ka māhuahua a aʻoi aku hoʻi.