Yanumet: nā analogues, nā ʻōlelo pili no ka hoʻohana ʻana, ka hoʻonohonoho ʻana a me nā loiloi

Hāʻawi kēia ʻaoʻao i ka papa inoa o nā hui āpau o Yanumet ma ke ʻano a me ka hōʻike no ka hoʻohana. ʻO kahi papa inoa o nā analogue maʻalahi, a hiki iāʻoe ke hoʻohālikelike i nā kumukūʻai i nā lāʻau lapaʻau.

• ʻO Yanueet ka hopena maʻalahi loa:Kūkākūkā
• ʻO ka mea kaulana loa o Yanumet:Vipdomet
• Hoʻolaha ATX: ʻO ka Metformin a me sitagliptin
• Nā mea waiwai / pilikino: metformin, sitagliptin
  

I ke helu ʻana i ke kumukūʻai yenumet? a ʻo ke kumukūʻai haʻahaʻa i loaʻa ma nā papa kumukūʻai i hāʻawi ʻia e nā lāʻau lapaʻau i lawe ʻia i ka mooolelo

Hāʻawi ʻia papa inoa o nā lāʻau lapaʻau kahua o nā helu helu o nā lāʻau lapa i noi nui ʻia

Nā kuʻuna i ka hoʻonohonoho ʻana a me nā hōʻike no ka hoʻohana

ʻO ka papa inoa ma luna o nā mea hoʻohālikelike lapaʻau, e hōʻike ana koho iā Yanumet, kūpono loa ia no ka mea ua like lākou me ka like o nā mea hana a me ke kūleʻa e like me ke kuhikuhi ʻana no ka hoʻohana

Nā kumuhana ma o ka hōʻike ʻana a me ke ʻano o ka hoʻohana ʻana

Ka ʻokoʻa like, hiki ke pili pū i ka hōʻike a me ke ʻano o ka noi

Pehea e ʻike ai i kahi analogue ʻano maʻalahi o kahi lāʻau lapaʻau nui?

No ka ʻike ʻana i kahi analogue kūʻai like ʻole i ka lāʻau lapaʻau, kahi generic a i ʻole synonymation, ʻo ka mea mua mua mākou i manaʻo no ka hoʻolohe ʻana i ka hoʻopili ʻana, ʻo ia nā ʻano like ʻole o nā mea kaha a me nā hōʻailona no ka hoʻohana. Hōʻike ka mea like ʻole o ka lāʻau lapaʻau me ka lapaʻau a like pū me ka lāʻau lapaʻau, kūloko a me ka mea pono i ʻole nā ​​lāʻau lapaʻau. Eia naʻe, mai poina e pili ana i nā māhele like ʻole o nā lāʻau like like, e hiki ai ke hoʻopilikia i ka palekana a me ka hana. Mai poina e pili ana i nā ʻōlelo aʻo a nā kauka, hiki i ka lāʻau lapaʻau iho ke hōʻino i kou olakino, no laila e ʻōlelo mau i kāu kauka ma mua o ka hoʻohana ʻana i kekahi lāʻau lapaʻau.

Nā ʻōlelo aʻoaʻo Janumet

NA ININA
ma ka hoʻohana o ka lāʻau lapaʻau
YANUMET

E hoʻokuʻu i ke ʻano
Nā Palaki

Hōʻike
1 ka papa ʻoniʻoni ʻoniʻoni ma kahi: Sitagliptin phosphate monohateate 50 mg, Metformin hydrochloride 500, 850 a me 1000 mg.
Nā mea kū'ē: microcrystalline cellulose 59.30 mg, povidone 48.23 mg, sodium stearyl fumarate 13.78 mg, sodium lauryl sulfate 3.445 mg.
Ia ka puʻu o nā papa Opadray II Pink, 85 F 94203 (17.23 mg) i loaʻa: polyvinyl alkohol 47,800%, titanium dioxide (E 171) 6,000%, macrogol - 3350 23.500%, talc 22.590%, black iron oxide (E 172) 0.005% ulaula pōʻaiʻai hao (E 172) 0.105%.

ʻOhiʻohi
Aia he 14 papa i kahi kōā. I loko o kahi pākēpē o nā pahu he 4.

Ka hana lāʻau lapaʻau
ʻO ka laʻa ʻo Janumet kahi hui pū me ʻelua mau lāʻau hypoglycemic me ka hana hoʻohui (koi) o ka hana, i hoʻolālā ʻia e hoʻomaikaʻi hou i ka mana glycemic i nā mea maʻi me ka maʻi type 2: sitagliptin, he mea hoʻohui o ka peptidyl peptidase-4 (DPP-4), a me metformin, he māka o ka papa biguanide.
ʻO Sitagliptin kahi hana waha, paʻa paʻa DPP-4 inhibitor no ka mālama ʻana i ka maʻi type 2. ʻO nā hopena i mālama i ka hopena o ka papa lāʻau o nā mea paʻa o ka DPP-4 i hoʻomohala ʻia e ka hoʻoweliweli ʻana o nā pakanui.Ma ka hoʻokaʻawale ʻana i DPP-4, hoʻonui ka sitagliptin i ka hoʻoliʻiliʻi o ʻelua mau ʻōiwi ikaika o ka ʻohana kinalula: peptide e like me ka peptide 1 (GLP-1) a me ka glucose-e hilinaʻi i ka insulinotropic polypeptide (HIP). ʻO ka incretins he ʻāpana o ka pūnaehana physiological kūloko no ka hoʻoponopono o ka homeostasis glucose. I ka hoʻonaninani kūlohelohe a hoʻonaninani ʻia paha, na GLP-1 a me nā GUI e hoʻonui i ka synthesis a me ka huna ʻana o ka insulin e nā pancreatic beta cells. Hoʻopili hoʻi ka GLP-1 i ka mea huna o ka glucagon e nā ʻāpana alpha pancreatic, no laila ke hoʻohaʻahaʻa nei, no laila, ke ʻano o ka hoʻohuihui ʻana o ka glucose i loko o ka ate. ʻOkoʻa kahi ʻano hana o ke ʻano he hana i ka hana o nā derivatives o sulfonylurea, ka mea e hoʻoulu ai i ka hoʻokuʻu ʻana o ka insulin a hiki i ka helu ʻana i ka hoʻoliʻi haʻahaʻa o ke koko, ka mea i hoʻopiʻi ʻia me ka hoʻomohala ʻana o ka hypoglycemia sulfony ʻaʻole wale nō i nā mea maʻi me ka diabetes mellitus type 2, akā pū nō hoʻi i nā mea olakino. ʻO ka lilo ʻana i mea koho maikaʻi loa a me ka maikaʻi o ka hoʻonaninani DPP-4, sitagliptin i loko o ka hoʻoulu ʻana o ka therapeutic, ʻaʻole ia i kāohi i ka hana o nā huina e pili ana i ka DPP-8 a i ʻole DPP-9. ʻOkoʻa ka Sitagliptin i ka hana kemika a me ka hana pharmacological mai nā analogues o GLP-1, insulin, sulfonylurea derivatives a me meglitinides, biguanides, gamma receptor agonists i hana ʻia e peroxis proliferator (PPARy), nā alpha-glycosidase inhibitors a me nā amylin analogues.
ʻO ka Metformin ka lāʻau lapaʻau hypoglycemic e hoʻonui i ka hoʻohaʻahaʻa glucose i nā poʻe maʻi me ka maʻi diabetes 2 ʻano, e hoʻemi ana i ka basal a me ka pakanui koko hoʻonaʻauao koko. Kū ʻokoʻa nā kaila pharmacological o nā hana i nā hana o ka hana o ka lāʻau hypoglycemic waha o nā papa ʻē aʻe. Hoʻomau ka Metformin i ka hoʻohuihui glucose i ka ate, hoʻoneʻe i ke kao o ka glucose hāwau, a hoʻonui i ke ʻano o ka insulin ma o ka hāpai ʻana a me ka hoʻohana ʻana i nā glucose

Janumet, mau hōʻailona no ka hoʻohana ʻana
Ua hōʻike ʻia ʻo Yanumet he hoʻohui i ka mea ʻai a me ka hoʻoponopono regimen e hoʻomaikaʻi i ka mana glycemic i ka poʻe maʻi me ka diabetes mellitus type II ʻaʻole i loaʻa ka pono pono ma ka ʻaoʻao o ka monotherapy me metformin a sitagliptin paha, a ma hope o ka hoʻomaʻamaʻa ʻana o ka hopena hui ʻole me ʻelua mau lāʻau. Hōʻike ʻia ʻo Yanumet i ka hui pū me nā derogative sulfonylurea (kahi hui o ʻekolu mau lāʻau) ka hoʻohui i ka meaʻai a me ka hoʻoponopono regimen e hoʻomaikaʻi ai i ka mālama glycemic i nā mea maʻi me ka maʻi type II i loaʻa ʻole i ka ʻoluʻolu o ka hopena ma hope o ka mālama ʻana me ʻelua o kēia mau lāʻau ʻekolu: metformin, sitagliptin a derivatives huikaʻi. Ua hōʻike ʻia ʻo Janumet i hui pū me PPAR-? Agonists (no ka laʻana, thiazolidinediones) i hoʻohui i ka ʻai a me ka hoʻoponopono regimen e hoʻomaikaʻi i ka mana glycemic i loko o nā mea maʻi me ka maʻi type II ka poʻe i loaʻa ʻole ka loaʻa kūpono ma hope o ka mālama ʻana me ʻelua o kēia mau huaʻala mai ʻekolu: metformin, sitagliptin, a me PPAR-β agonist. Hōʻike ʻia ʻo Yanumet no nā maʻi me ka diabetes mellitus type II (kahi hui pū me ʻekolu mau lāʻau) ma ka hoʻohui i ka meaʻai a me ka hoʻoponopono ʻana no ka hoʻomaikaʻi ʻana i ka mana glycemic i hui pū me ka insulin.

Nā Hoʻohui
- Hypersensitivity no sitagliptin phosphate, metformin hydrochloride a i ʻole kekahi mea ʻē aʻe o ka lāʻau,
- nā maʻi koʻikoʻi e hiki ke hoʻopilikia i ka hana o nā keiki maʻa: nā huhū, nā maʻi hōʻeha, nā haʻalulu
- nā maʻi a me ka maʻi kūlia paha e hiki ke alakaʻi i ka hypoxia kiko, e like me ka puʻuwai a i ʻole hoʻi i ka hanu, ʻo ka wā neocardial infarction hou, pāhoihoi,
- hōʻemi a i ʻole ka hopena renal impairment (clearance cleince
- hana hewa pāpaʻi hemahema,
- ulana pōpilikia o ka ʻawaʻawa, inu ʻemi,
- wā waiū,
- maʻi mellitus type I,
- ka aila o ka metabolic acidosis maʻi, me ka ketoacidosis maʻi maʻi (me a ʻole ʻole coma),
- nā noiʻi radiological (hoʻokele kūlohelohe o nā yodine e kūlike i ka mana).

ʻLoe a me ke kākele
E koho pono ʻia ka nui o ka nui o ka lāʻau i ka lāʻau Yanumet, e pili ana i ka maʻi o kēia manawa, ka hana a me ka hiki ke kūpono, akā ʻaʻole ia eʻoi aku i ka nui o ke koina i kēlā me kēia lā kahi sitagliptin 100 mg. ʻO ka lāʻau Yanumet e hōʻike pinepine ʻia i 2 mau manawa i ka lā me ka pāʻina, me ka hoʻonui liʻiliʻi i ka waiū, i mea e hōʻemi ai i nā hopena ʻaoʻao mai ka gastrointestinal tract (GIT), ka ʻano o ka metformin. ʻO ka palena mua o ka lāʻau Janumet e hilinaʻi nei i ka manawa hypoglycemic therapy i kēia manawa.

ʻŌpū a me ka lactation
ʻAʻohe pono e hoʻokele pono ʻia nā lāʻau ʻo Yanumet a me nā mea pono i nā wahine hāpai, no laila, ʻaʻohe ʻikepili i ka palekana o ka hoʻohana ʻana i nā wahine hāpai. ʻO ka lāʻau ʻo Janumet, e like me nā lāʻau lapaʻau hypoglycemic waha, ʻaʻole ʻia no ka hoʻohana ʻana i ka wā hāpai. ʻAʻohe nō hoʻokolohua hoʻokolohua i hoʻohālikelike i ka lāʻau Yanumet hui pū ʻia e nānā i kona hopena ma ka hana reproduction. Loaʻa nā ʻikepili i loaʻa mai nā noi ʻana o sitagliptin a me metformin i hōʻike ʻia.

Nā hopena hopena
Mai ke kaomi hana ʻana: ma ka hoʻomaka o ka papa o ka mālama - ana - anorexia, ʻehaʻeha, nausea, ka luaʻi, ka lemela, ʻeha o ka ʻōpū (hōʻemi me ka meaʻai), ka ʻaha metallic i loko o ka waha (3%).
Mai ka pūnaehana cardiovascular a me ke koko (hematopoiesis, hemostasis): i nā hihia kaʻawale - megaloblastic anemia (kahi hopena o ka malabsorption o ka vitamin B12 a me ka folic acid).
Mai ka ʻaoʻao o ka hana metabolism: hypoglycemia, i nā hihia līkeke - lactic acidosis (nāwaliwali, ke hiamoe nei, hypotension, ka bradyarrhythmia kūmau, ka maʻi hanu, ʻeha ʻeha, myalgia, hypothermia).
Mai ke kino: rash, dermatitis.

Nā ʻōlelo kikoʻī
Hoʻohana ʻia i ka Yanumet kahiko: ʻo ke ala nui o ka hoʻopau ʻana i ka sitagliptin a me ka metformin nā palaka, a mai ka hana o ka hana i loko o ka pēpē e emi me ka wā o ka makahiki, nā mea mua o ka mālama ʻana i ka lāʻau Yanumet e hoʻonui i ka hapa ʻana i ka makahiki. Ma muli o ka maʻi ʻomaʻomaʻo nā maʻi ma lalo o ke koho ʻana a me ka mālama pinepine ʻana i ka hana māka.

Hoʻohui nūhou
ʻO Sitagliptin a me metformin
ʻO ka ka manawa like o ka nui o nā sitagliptin (50 mg 2 mau manawa i kēlā me kēia kī) a me ka metformin (1000 mg 2 mau manawa i ka lā) ʻaʻole i hele pū ʻia e nā loli koʻikoʻi i ka laikini pharmacokinetic o sitagliptin a i like me ka metformin i nā mea maʻi me ka maʻi maʻamau ʻo 2.
Ua mālama ʻia nā noi ʻana o ka hopena interdrug ma ka parekola pharmacokinetic o ka lāʻau Janumet, eia naʻe, ua paʻa ʻia kahi nui o ia mau noiʻi no kēlā me kēia mea pono o ka lāʻau, sitagliptin a me metformin.
Sitagliptin
Ma nā haʻawina e pili ana i ka hoʻopili ʻana me nā lāʻau lapaʻau ʻē aʻe, ʻaʻole i loaʻa i kahi kūlana koʻikoʻi ke sitagliptin i ka pharmacokinetics o kēia mau lāʻau lapaʻau: metformin, rosiglitazone, glibenclamide, simvastatin, warfarin, contraceptives waha. Ma muli o kēia mau ʻike, ʻaʻole sitalliptin pale i nā CenP isoenzymes o ka cytochrome CYP3A4,2C8 a i ʻole 2C9 ʻōnaehana. I loko o nā hōʻike vitro hōʻike i kahi sitagliptin ʻaʻole i pale i ka CYP2D6,1A2,2C19 a me ka 2B6 isoenzymes a ʻaʻole e hoʻoulu iā CYP3A4. Wahi a ka loiloi pharmacokinetic o ka poʻe maʻi me ka diabetes type type 2 mellitus, ʻaʻole i loaʻa i ka hopena koʻikoʻi nā maʻi i ka pharmacokinetics o sitagliptin. Ua loiloi ʻia ka noiʻi ʻana i kekahi mau lāʻau lapaʻau maʻamau e hoʻohana pinepine ʻia e nā mea maʻi me ka diabetes mellitus type 2, i hui pū ʻia me: nā hypocholesterolemic drug (statins, fibrates, ezetimibe), nā antiplatelet agents (clopidogrel), nā lāʻau antihypertensive (ACE inhibitors, angitensin II receptor antagonists, beta-blockers, blockers “Slow” kalima pālua, hydrochlorothiazide, analgesics a me nā lāʻau non-steroidal anti-inflammatory (naproxen, diclofenac, celecoxib), antidepressants (bupropion, fluoxetine, sertraline), antihistamines (ceti Rizin), nā mea hoʻomalu proton (omeprazole, lansoprazole) a me nā lāʻau lapaʻau no ka mālama ʻana i ka ʻeha erectile (sildenafil).
ʻO ka hoʻonui ʻana o AUC (11%), me ka awelika C max (18%) digoxin i hoʻomaopopo ʻia i ka wā e hui pū ai me sitagliptin.ʻAʻole i manaʻo ʻia kēia hoʻonui e koʻikoʻi nā maʻi, akā, ʻo ka nānā ʻana o ka mea maʻi i aʻo ʻia ke lawe ʻana i ka digoxin ʻO ka hoʻonui ʻana o ka AUC a me C max o sitagliptin i ʻike ʻia e 29% a me 68%, pākahi, me kahi nīnū waha hoʻokahi o ka lāʻau YANUVIA ma kahi o ka 100 mg a me cyclosporin (kahi paʻa iʻike o ka p-glycoprotein) i kahi kakama o 600 mg. ʻAʻole koʻikoʻi kēia mau loli i ka lāʻau pharmacokinetic o sitagliptin.
Metformin
ʻO Gliburide - i loko o ke aʻoʻana o ka pilina o ka interdrug o nā pā o ka metformin a me nā gliburide i nā mea maʻi me ka maʻi diabetes mellitus type 2, ʻaʻohe loli i ka pākuʻi ʻo pharmacokinetic me pharmacodynamic o metformin i nānā. He loli nui nā loli i ka AUC a me Stax glyburide. Ka ʻikepili ʻokoʻa (kahi pākahi hoʻokahi) a me ka mehameha o ke kaila o ka plasma o ka glyburide me nā hopena farmacodynamic i ʻike ʻia i ke ʻano o ke koʻikoʻi o kēia pilina.
Furosemide - i loko o kahi noiʻi o ka hopena o ka lāʻau i ka hopena o ka hopena hoʻokahi o ka metformin a me ka furosemide i nā mea hana olakino maikaʻi, kahi hoʻololi i loko o nā pākuʻi pharmacokinetic o nā lāʻau ʻelua i mālama ʻia. Ua hoʻonui ʻo Furosemide i ke kao o ka metformin C max i ka plasma a me ke koko āpau ma ka 22%, ke ʻano nui o ka AUC o ka metformin i ke koko holoʻokoʻa ma ka 15%, me ka ʻole o ka hoʻololi ʻana i ka hoʻomaʻemaʻe kino o ka lāʻau. ʻO nā waiwai o C max a me AUC o ka furosemide, ma ka huli ʻana, i hōʻemi ʻia e 31% a me 12%, kēlā, a me ka hapalua o ke ola i hōʻemi ʻia e 32%, ʻaʻohe o nā loli nui ma ka wehe ʻana i ka papala o ka furosemide. ʻAʻohe ʻike e pili ana i ka hoʻopili olohila waena o nā lāʻau ʻelua ʻelua me ka hoʻohana lōʻihi ʻana.
Nifedipine - i ka hoʻopaʻaʻana o ka hopena o ka lāʻau o ka nifedipine a me ka metformin ma hope o hoʻokahi mau lāʻau i nā lāʻau lapaʻau e nā poʻe lawelawe olakino, he hoʻonui nui ʻia ka plasma C max a me AUC o ka metformin e 20% a me 9%, i kēlā me kēia mea, a me ka hoʻonui ʻana i ka nui o ka metformin i hoʻopā ʻia e nā kidney, ua hōʻike ʻia. ʻAʻole i loli ka T me ka hapalua o ke ola o ka metformin. Kūkulu ʻia ia e ka hoʻonui i ka kahe o ka metformin i ke alo o ka nifedipine. ʻO ka hopena o ka metformin ma ka pharmacokinetics o ka nifedipine ka mea liʻiliʻi.
Nā lāʻau lapaʻau cationic - cationic drug (i.e., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprim a vancomycin), huna ʻia e ka neʻe tubular, hiki ke hoʻōla pū me ka metformin, hoʻokūkū no ka renal tubular hoʻohele. ʻōnaehana ʻōnaehana. Ua nānā ʻia ka hoʻokūkū like me ka hoʻokō ʻana o ka metformin a me ka cimetidine e nā poʻe lawelawe olakino i ka noi ʻana hoʻokahi a me ka nui, me kahi 60% e hoʻonui i ka kao o C max metformin i ka plasma a me ke koko āpau a me kahi hoʻonui 40% i ka AUC o ka metformin i ka plasma a me ke koko āpau. I loko o hoʻokahi noiʻi lāʻau hoʻokahi, ʻaʻole i loli ka hapalua o ke ola o ka metformin. ʻAʻole i pili i ka Metformin i ka pharmacokinetics o cimetidine. A ʻoiai he mea nui kēia mau mea pili i ka lāʻau lapaʻau (me ka ʻokoʻa o ka cimetidine), ka mālama pono ʻana i ka mea maʻi a me ka hoʻoponopono ʻana o ka lāʻau i ka laʻana o Janumet a me / a i nā lāʻau lapaʻau ma luna aʻe, i hoʻopili ʻia e nā proula maxima proximal, i ʻōlelo ʻia i nā hihia o kā lākou lawelawe like ʻana.
Loaʻa i kekahi mau lāʻau lapaʻau hyperglycemic hiki a ke uhaʻi i ka hoʻomohala paʻa glycemic. Hoʻopili kēia i ka thiazide a me nā diuretics, glucocorticosteroids, phenothiazines, ka hoʻomākaukau ʻana i ka thyroid, estrogens, contraceptives waha, phenytoin, ka waikika nicotinic, sympathomimetics, nā mālamuhulu hāpana palaka a me isoniazid. Ke koho ʻana i kēia mau lāʻau lapaʻau, loaʻa i ka mea maʻi ka lāʻau Janumet, ʻoi ʻia ke nānā me ka nānā ʻana i nā alaloa pili i ka glycemic control.ʻOiai ua lawe aku nā mea ola olakino i ka metformin a me propranolol a i like me ka metformin a me ka ibuprofen, ʻaʻohe mākaʻi o ka pharmacokinetic o kēia mau lāʻau.
ʻO kahi hapa wale o ka metformin e hoʻopili ai i ka protein plasma, no laila, ʻo ka pilina o ka lāʻau kūloko o ka metformin me nā lāʻau lapaʻau e hoʻopili paʻa ai i nā protein plasma (salicylates, sulfonamides, chloramphenicol a me ka probenecid) i ʻole nā ​​mea like ʻole, e like me sulfonylureas, kahi e hoʻopili ai i nā protein plasma.

Ke keu
Sitagliptin: I loko o nā limahana olakino, ʻae ʻia ke ʻano o nā pae hoʻokahi a hiki i 800 mg. I ka wā i noiʻi ʻia i loko o kahi noiʻi haumanu, kahi kikoʻi o 800 mg i hōʻike i kahi l lōʻihi o ka palena Q - Tc, ʻaʻole i manaʻo ʻia he koʻikoʻi koʻikoʻi. ʻAʻoheʻike me ka hoʻohana o ka lāʻau lapaʻau ma nā iniha heʻoi aku o ka 800 mg. Ma nā noiʻi, ʻaʻohe hewa i hoʻopili ʻia i ka hopena o ka lāʻau lapaʻau i ka wā e hoʻohana ai i ka 600 mg / lā no nā lā 10 a me 400 mg no nā lā 28. Ua hilahila maikaʻi ʻia ka sitagliptin: e like me nā haʻawina loiloi, ʻo 13.5% wale nō ka nui o ka loaʻa i ka excreted i loko o ka hālāwai hemodialysis 3-4-hola. I ka hihia o nā pono lapaʻau, ua kau ʻia nā hemodialysis lōʻihi. ʻAʻohe mea hōʻike i ka hopena o ka dialysis peritoneal no sitagliptin. Metformin: aia kekahi mau hihia o ka overdose o ka metformin, me ka hoʻokele ʻana ma nā kumukūʻai he keu 50 g. Ua ʻike ʻia ʻo Hypoglycemia ma kahi o 10% o nā hihia a pau o ka overdose, eia naʻe, kahi pilina kumu me kahi overdose o metformin ʻaʻole i hoʻokumu. ʻO ka hoʻolālāʻana o ka acidosis lactic i hōʻike ʻia ma kahi o 32% o nā hihia a pau o ka overdose o metformin. Pono hemodialysis no ka pilikia (dialyzed ka metformin i ka wikiwiki a hiki i ka 170 ml / min i nā kūlana o ka hemodynamics maikaʻi) e wikiwiki ai ka wehe ʻana o ka mea nui o ka metformin i nā hihia o ka overdose i manaʻo ʻia. Ma ka hihia o ka lāʻau lapaʻau nui, pono ʻo Janumet e hoʻomaka i nā hana kākoʻo maʻamau: e wehe ana i ka papa o ke gastrointestinal i ke koena o ka lāʻau i ka wā i kū ʻole ʻia, ka nānā ʻana i nā hōʻailona koʻikoʻi, e pili ana i ka ECG, hemodialysis, me ka hoʻopuka ʻana i nā mālama mālama, inā pono.

Nā kūlana mālama
Store ma kahi wela ʻaʻole oi aku 25 ° C.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

ʻO ka hoʻohālikelike o kēia lāʻau lapaʻau ka mea nui aia i ʻelua mau mea ikaika e hoʻohui i kekahi i kekahi i ka manawa hoʻokahi. ʻO ka mea nui o ka lāʻau lapaʻau ka metformin hydrochloride. Loaʻa ka lāʻau lapaʻau "Yanumet" i loko o ke ʻano o nā papa. ʻO ia, e lawe pono ʻia. ʻO ka metformin i ka mana o kekahi papa like me ka 500, 850 a i ʻole 1000 mg.

ʻO ka papa hana lua o Yanumet he sitagliptin. ʻO kēia waihona, me ka mea o ka manaʻo o ka metformin hydrochloride, e hoʻopili mau ʻia i ka nui o 50 mg i hoʻokahi papa. ʻO nā mea hoʻoikaika ʻelua o ka lāʻau lapaʻau e hiki ke mālama pono i ka hoʻokaʻina o ke koko koko o ka mea maʻi.

ʻOiaʻiʻo, e like me kekahi mau pale ʻē aʻe, ka hui ʻana o "Yanumet" pili i nā mea kōkua. Akā ʻaʻole kekahi o lākou i hopena hopena i ke kino o ka mea maʻi.

I ka hana ʻana o nā papa i kēia lāʻau lapaʻau ke hoʻomau ʻia nei, ka mea, ʻoiai, he ʻano hana hoʻohuihui paʻakikī. Mahalo i kēia ʻano hoʻokuu, ʻaʻole i loaʻa i nā ʻōlelo ʻo Yanumet nā hopena ʻino loa o ka mucosa gastric o nā maʻi.

He aha ka metformin hydrochloride?

Loaʻa ka pōmaikaʻi o kēia waiwai no ka poʻe maʻi me ka diabetes mellitus type 2, ʻo ia ka mea mua, i ka wā e komo ai i ke kino, e hoʻemi ana ia:

ka hoʻohuihui o ka glucose i ka ate,

ka ʻōpū ʻana i loko o ka ʻōpū.

ʻO kēia māhele o Yanumet a me nā mea kikoʻī o kēia lāʻau lapaʻau me ka like pū me ia e hiki ai ke hoʻonui i ka naʻau o nā cell i ka insulin ma o ka hopu ʻana a me ka hoʻohana ʻana i ka glucose.Nui nā mea i hoʻonā i ke kumukūʻai nei, e pili ana i ka pūʻulu o nā hua lāʻau mono, i hana ʻia ma ke kumu o ka metformin wale nō he mea ikaika.

Pehea e hana ai ka sitagliptin?

ʻO kēia ʻano hana ikaika o Yanumet i loko o ke kino o ka mea maʻi me ka maʻi diabetes type 2 e pale i ka enzyme DPP-4, ke alakaʻi nei i ka hoʻonui ʻana o ka holomua o nā hormones ikaika GLP-1 a me HIP, ka mea nāna e mālama i ka lāʻau pilikino o ka glucose. Kuhi ʻia ka hana o DPP-4 i ka wā e lawe ai i nā mea maʻi "Yanumeta" i hoʻopaʻa ʻia no kahi 24 hola. No ka hoʻohālikelike ʻana me ka metformin, ʻike ʻia ka sitagliptin he wahi liʻiliʻi loa ia no ka kino o ke kanaka maʻi ma ke ʻano o nā hopena ʻaoʻao. ʻO nā monopreparations i manaʻo ʻia e hoʻomau i ke kiʻekiʻe o ka kō koko koko i nā maʻi me ka maʻi maʻi maʻamau e hana pinepine ʻia i kāna kumu.

Nā mea hou aku

Hoʻohui pono i ka metformin hydrochloride a me sitagliptin, ʻo ka waihona o Yanumet e loaʻa i kēia mau mea kōkua e like me:

Kahu o ka papa o kēia mau papa, ma waena o nā mea ʻē aʻe, polyvinyl ka ʻona, titanium dioxide, talc, ʻeleʻele a me ka ʻioʻo hāleo, macrogol. Inā maʻi kahi mea maʻi me ka maʻi maʻi e pili ana i kēia mau mea, pono ʻoe e hōʻole e lawe iā Yanumet.

ʻO nā analog e hoʻohana pono ai

ʻO ke kumukūʻai o nā papa no Yanumet e hilinaʻi nui ʻia i ka nui o ka metformin hydrochloride e hoʻokomo i ko lākou hoʻohui pū. ʻO kēia lāʻau lapaʻau, i hoʻolako ʻia mai ka Netherlands (me ka hoʻopiʻi ma Rūsia), ʻo, naʻe, he mea kūʻai nui loa. No ka laʻana, ʻo ka pākuhi o nā papa "Yanumet" i ka nui o nā 56 mau pcs. ma kahi pānaʻi o 500 mg e uku ai i ka mea maʻi, e hilinaʻi nei ma ka ʻāina, 2500-3000 p. No laila, he nui ka poʻe me ka diabetes type 2, ʻoiaʻiʻo, ke makemake nei e komo inā loaʻa i kēia lāʻau lapaʻau nā mea maʻalahi haʻahaʻa.

Eia nō naʻe, ʻo ka hoʻomākaukau me ka hoʻolālā like like o Yanumet ʻaʻole i hana ʻia ma Rūsia. ʻAʻole ka haʻahaʻa o ka hapa nui o nā haole kūwaho i ke kumukūʻai o kēia hāmeʻa. ʻO ke ʻano mea like ʻatikala no ka lāʻau "Yanumet", i kūʻai ʻia ma ke kumu kūʻai, ma Lūkini ma kēia manawa ʻo "Galvus Met".

ʻO ka mea e pono ai ke kūlohelohe kūpono no kēia huahana me ka pūnaehana like ua manaʻo ʻia ʻo ia ʻo Velmetia i kēia manawa. ʻO ka poʻe e ʻimi nei i kahi mea hoʻohālike o Yanumet 1000 + 50 mg, ma ka laʻana, pono e mālama mua i kēia lāʻau.

Eia kekahi, i kekahi mau hihia, hiki ke loli ʻia kēia lāʻau e ka:

No kēia mau analogue o Yanumet, hoʻolako ʻia nā ʻōlelo hoʻohana no ka hoʻohana pono ʻana i nā mea like me kēia lāʻau lapaʻau iho. Akā, ua like ka like me ka hoʻolālāʻana o kēia mau lāʻau. No laila, hiki i ka kāohi o ke kō me kā lākou hoʻohana ke lawe e like me nā ʻano ʻē aʻe. I kēlā me kēia mea, he mea e pono ai ke hoʻololi i ka Yanumet i kēia mau lāʻau lapaʻau, ʻoiai, me nā mea ʻē aʻe, ma ke ʻano o ke kauka.

Eia kekahi, i kekahi mau hihia, hiki ke hoʻololi iā Yanumet e ka hui pū ʻana me nā mea hoʻohana liʻiliʻi ʻelua - ʻo Lisavia (Holani) a me Glucophage, kahi mea he metformin kumu.

ʻO ka lāʻau lapaʻau "Galvus Met"

No kēia lāʻau pili i ke ʻano o "Yanumet" hui pūpili. 1000 a 50 mg ʻo ia kekahi o nā hana maʻamau. ʻO kekahi o nā mea hana e hana nei i loko he metformin. Akā ma kahi o sitagliptin, ua hoʻopili ʻia ka vildagliptin i kona ʻano i loko o ka huina o 50 mg. Ka mahina o ka mālama ʻana me kēia lāʻau lapaʻau, e kūʻai i kahi mea maʻi me ka maʻi maʻi e pili ana i ka 1600 p. Loaʻa kēia lāʻau lapaʻau i nā papa a manaʻo ʻia no ka hoʻokō waha.

Hoʻopili ʻia ʻo Metformin i ka hui pū ʻana o nā mea hoʻohui o Yanumet, ʻo Combogliz Prolonga a me Gentadueto. I kēia hihia, ʻo ka lāʻau lapaʻau mua hoʻohui i nā saxagliptin, a me ka lua - linagliptin.

Lime "Velmetia"

ʻO kēia lāʻau lapaʻau e hana ʻia e ka mea ʻike maikaʻi ma Rusia, Berlin-Chemie. ʻO ia i hana nui ʻia ma nā ʻoihana o Italia a me Sepania. ʻO nā mea nui a pau o kēia lāʻau lapaʻau, e like me Yanumet ponoʻī, ʻo ka metformin a me sitagliptin.Eia kekahi, ua hoʻolako ʻia kēlā lāʻau lapaʻau i ka mākeke i nā ala ʻelua: 850 + 50 mg a me 1000 + 50. Ma Lusia, kahi o nā Velmetia analogue o Yanumet, ʻaʻole naʻe, hiki ke kūʻai wale ʻia ma ke kauoha. Eia kekahi, ʻo ke kumukūʻai kēia mea kūʻai aku kekahi.

Nā kumu kūʻai uku

Ma Lūkia, nā kikowaena o Yanumet 1000 + 50 mg, 850 + 50 mg, a pēlā aku, he mau lā. Akā, ʻo ia mau lāʻau āpau, i hoʻohālikelike ʻia me kēia lāʻau lapaʻau (ʻoiai ua loaʻa ka like a me ke ʻano like ʻole), he mea ʻole ke kumukūʻai. Eia nō naʻe, ʻikeaʻi ʻia nā mea e like me kēia lāʻau lapaʻau, i hana ʻia ma ke kumu o nā ʻāpana ʻē aʻe a i ʻole ke ʻano he mea hoʻohālike, no ka hana ʻana i nā hale kūʻai i nā lāʻau lapaʻau, ʻoiaʻiʻo nō. I ka nui o nā hihia, e hoʻoholo ʻia e nā loiloi o nā maʻi, hoʻohiolo ʻia lākou i ke kō koko koko ma mua o ka mea kumukūʻai, hoʻomohala ʻia i ka mālamalama o nā hoʻokō ʻepekema hou loa, ʻo Yanumet. Akā, ʻo nā lāʻau lapaʻau no ka maʻi maʻi, ʻoiaʻiʻo, hiki ke lilo i mea maikaʻi loa.

No ka laʻana, hiki ke hoʻopili ʻia nā lāʻau lapaʻau e hiki mai ana i ka hui o nā analogue o nā haʻahaʻa o ka lāʻau Yanumet:

Hoʻolaha pinepine ʻia kēlā mau lāʻau i ka poʻe me ka maʻi maʻi e nā kauka. Manaʻo nā nui o nā maʻi āpau i kēia mau ʻōlima home o Yanumet i mea maikaʻi loa.

Nā hōʻailona no ka hoʻohana ʻana

ʻAe ʻia ka lāʻau "Yanumet" e nā kauka no nā maʻi me ka maʻi maʻi pinepine. ʻOiaʻiʻo, kēia lāʻau lapaʻau, e like me nā mea like ʻole, ma ka lapaʻau ʻia he hoʻohui wale nō i ka meaʻai i hoʻolālā ʻia no ka mea maʻi a me ka hoʻoponopono o ka hana kino. He ʻoi loa ia inā he hele ʻia ka maʻi ma ke kanaka me ka hiʻona.

Manaʻo pinepine, kauka kauka kau i nā mea maʻi me ka diabetes type type 2 mellitus "Yanumet" i hui pū me nā lāʻau ʻē aʻe. No ka laʻana, i nā nui he nui i hui pū ʻia me nā derogative o sulfonylurea, nā mea agarist PPAR, a me insulin.

Nā Hoʻohui

Ua kuhikuhi ʻia kēia lāʻau lapaʻau hou, e like me nā mea ʻē aʻe, ʻoiaʻiʻo, ʻaʻole nā ​​maʻi āpau i hiki. ʻAʻole hiki iā ʻoe ke hoʻohana i ka lāʻau "Yanumet" e kaohi i ke kō o ke kō koko koko e like me nā ʻōlelo a me nā kikowaena 1000 + 50 mg, 500 + 50 mg, 850 + 50 mg o kēia lāʻau lapaʻau? ʻAʻole i kuhikuhi ʻia kēlā mau ʻano lāʻau, ʻo ia hoʻi i kēlā mau mea maʻi e loaʻa ka hypersensitivity i kā lākou ʻelua a i ʻole nā ​​mea kōkua ʻē aʻe. Ke manaʻoʻiʻo ʻia ʻole hiki ʻole iā ʻoe ke lawe i nā lāʻau lapaʻau i nā maʻi me nā maʻi koʻikoʻi e hiki ʻole ai ke hoʻopōʻino i ka hana o ka palu:

me nā maʻi koʻikoʻi.

Ua kauka nā kauka i nā maʻi maʻi maʻi "Yanumet" a me kekahi o nā mea hoʻohālike no ka maʻi maʻi aʻai ʻole paha e alakaʻi ana i ka hypoxia kiko:

i ka hanu ʻana a i ʻole ka naʻau hemahema,

wā keiki myocardial wā hou.

ʻAʻohe hihia e lawe i kēia lāʻau lapaʻau no ka hoʻohālikelike, no ka laʻana, me ka waiʻona. ʻOiaʻiʻo, pili kēia i nā kiko hoʻohālike o ka lāʻau lapaʻau Yanumet. E like me ka waiʻona, e like me kāu e ʻike nei, ua pāpā ʻole ʻia ka lawe ʻana i kahi lāʻau i ka mea ʻokoʻa, me ka ʻike ʻole i nā sorbents.

Pēlā nō, ʻaʻole i kuhikuhi ʻia ʻo Yanumet no:

lawelawe inoa ʻole.

ʻAʻole hiki iā ʻoe ke inu i kēia lāʻau lapaʻau i nā mea maʻi i ka wā noiʻi radiological inā ua hoʻokomo ʻia lākou me nā mea hoʻonaninani like ʻole iodine. Hōʻike ʻia ka lawe ʻana i kēia lāʻau lapaʻau mau hola 48 ma mua o ke kaʻina hana a me 48 mau hola ma hope o ia.

Me ka mellitus o ka mellitus o ka ʻano mua, ʻaʻohe hopena maikaʻi kēia hoʻomehana i ke kino o ka mea maʻi. No laila, i kēia hihia, ʻaʻole naʻe i kuhikuhi ʻia i nā mea maʻi. E like me nā mea hoʻohālikelike a me nā hili, "Yanumet" ʻaʻole i kuhikuhi ʻia no nā mea maʻi ma lalo o ka makahiki 18. ʻO nā makahiki o nā keiki kekahi o nā contraindications no kēia lāʻau lapaʻau.

Hiki iaʻu ke hoʻohana i ka wā hāpai a me ka lactation

ʻO ka mea pōʻino, ʻoiai ʻo ka hoʻomākaukau ʻana o ka Yanumet he mea hou ia, ʻaʻole i aʻo ʻia i loko o ka hopena o ka hopena maikaʻi ʻole i ka hānai hapuna.ʻAʻohe ʻikepili i kēia manawa ma luna o kona palekana no nā wahine hāpai a me kā lākou keiki. No laila, e like me kekahi mea'ē aʻe i ka wai koko koko e mālama ʻia, ua mālama ʻia ʻo Yanumet no ka hoʻohana ʻana i ka wā o ka gestation. ʻAʻole kuhikuhi ʻia kēia ʻano mālama ʻia no nā wahine lactating.

I nā hihia e pono ai e mālama me ka akahele

ʻO nā mea hana nui a Yanumet a me nā mea hoʻohālike o kēia lāʻau lapaʻau ka like o ka pūnao like i hoʻopili ʻia ma o nā ʻōpū. E like me kāu e ʻike nei, me ka wā ʻokoʻa, ka hoʻoneʻe ʻana o ka hana ʻana o kēia okana i nā kānaka. No laila, pono ke ʻano o ka lāʻau "Yanumet" no nā poʻe ʻelemakule me ka akahele. Pono ke kauka e koho i ka pona no ka mea maʻi nui loa. Eia kekahi, ʻo ka mālama ʻana i nā mea maʻi ma waena o ka maʻi diabetes 2 e pono ke lawe ʻia ma lalo o ka nānā ʻana o kahi loea. Pono ka nānā kiaʻi o ka hana i loko o ia mau mea maʻi.

Manaʻo nā maʻi ʻōpio e kākau i ka "Yanumet" wale nō ma hope o ka nānā ʻana i nā ʻōpū a hōʻoia a ua hana pono kēia kino. Inā ʻaʻole, he mea maʻi loa paha kēia e ʻike i nā hopena maikaʻi loa i ka wā e lawe ai iā Yanumet. ʻO kaʻoiaʻiʻo, me ka makaʻala, pono e kuhikuhi i kēia lāʻau i nā poʻe ʻōpio i loaʻa kekahi pilikia o ka pūpū.

He aha nā hopena hopena hiki ke kumu

Lawe ʻia kēia lāʻau lāʻau e ka poʻe me ka maʻi maʻi, e hoʻokolokolo ʻia e nā loiloi a nā maʻi maʻi a me nā kauka, ʻo ka mea maʻamau ka mea maikaʻi loa. Hoʻokahi nā hopena ʻaoʻao i ko lākou mālama ʻana. Kūkā pinepine lākou me ka like o ka like me ka ʻaoʻao paʻakikī me ka metformin me ka placebo. Akā, ʻo nā mea like, e like me nā lāʻau ʻē aʻe, ʻo Yanumet a me nā mea hoʻohālike o kēia lāʻau lapaʻau me ka hoʻohui like ʻana i kekahi mau hihia hiki ke hopena maikaʻi i ke kino o ka mea maʻi.

I ka hoʻomaka mua o ka hoʻōla me nā lāʻau lapaʻau, ʻike ʻia nā mea maʻi i nā hopena ʻaoʻao mai ka gastrointestinal tract. ʻO kēia paha kekahi, no ka laʻana, ka nisa, ka luaʻi, ka maʻi maʻi. Eia nō kekahi, nui ka poʻe maʻi e nānā i ke ʻano o ka ʻaha metallic i loko o ka waha i ka wā e lawe ai iā Yanumet. I kekahi manawa hoʻi kēia mea hana i ka ʻulaʻeha a me ka ʻeha ʻeha. I ka wā e pau ai ka wā o ka wāʻai.

Ma ka māhele o ka ʻōnaehana cardiovascular, ma ka mālama ʻana i kēia lāʻau, hiki i nā mea maʻi ke loaʻa i ka anemia. ʻO kēia ke kumu nui o ka loaʻa ʻana o ka waikawa folic a me ka vitamin B12 i ke kino o ka mea maʻi e lawe ana iā Yanumet.

Eia kekahi, i ka mālamaʻana i kēia lāʻau i nā mea maʻi, nā hopena like ʻole e like me:

ke hiamoe a nāwaliwali

I kekahi mau hihia, hiki i kēia lāʻau lapaʻau ke hōʻeha i ke kino o ka mea maʻi.

Pehea e lawe ai

Pehea e inu ai i kēia lāʻau lapaʻau e like me ke kauoha? Nā kikowaena o Yanumet me ka like pū me ka like a like me kēia lāʻau lapaʻau iho, ʻo ka mea pinepine ka poʻe maʻi e lawe hoʻokahi a ʻelua paha i ka lā me ka meaʻai. No ka hōʻalo ʻana i nā hopena ʻaoʻao, pono e hoʻonui ka nui o kēia lāʻau lapaʻau i ka pono e pono ai. Hoʻomaopopo nā kauka i nā mea ʻoki piha i ka papa ʻo Yanumet. E hoʻokō i ka hopena koʻikoʻi, ʻaʻole lākou e ʻae e wāwahi, wawā a ʻūlū paha.

I kekahi mau hihia, ʻaʻole e piha nui nā papa o kēia lāʻau i ka digestive tract. Inā loaʻa pinepine nā koena i nā moʻa, pono e hōʻike i ke kauka hele e pili ana i kēia. Ma hope o kēia, pono e nānā ke kauka i ka hopena o ka mana glycemic me ka hoʻohana ʻana i kēia pono hana.

Hāʻawi ʻia nā hehi

ʻO kaʻoiaʻiʻo, pono ʻoe e lawe paʻa e like me nā ʻōlelo aʻoaʻo "Yanumet" a me nā analogues o 1000 + 50 mg, 500 + 50 mg, 850 + 50 mg o kēia lāʻau lapaʻau, a me nā mea ʻē aʻe. ʻO ka nui o ka lāʻau Yanumet e pono ai e inu ka mea maʻi e pono ai, e hoʻoholo ʻia e ke kauka wale nō. ʻO ka maʻamau, ʻo ka maʻa mua o kēia lāʻau lapaʻau ʻo 500 mg o metformin + 50 mg o sitagliptin ʻelua i ka lā.

Lomi pinepine ʻia ʻo "Janumet" i kēlā poʻe maʻi i kōkua ʻole ʻia e nā monopreparations i loaʻa hoʻokahi wale nō o kēia mau mea. I kēia hihia, pono e hoʻākāka ʻia ka dosage mua e like me kekahi mau lula. Ma ka hana ʻole o ka hopena o ka metformin, no ka laʻana, ma ka manawa mua i kuhikuhi ʻia ka mea maʻi "Janumet" i kēlā me kēia mea ʻaʻole ia e lawe i ka 100 mg o ka sitagliptin i kēlā me kēia lā.

Ma ka hanana i mua o ka mālama ʻana me Yanumet i mālama ʻia ka mea maʻi me sitagliptin, ua ʻōlelo ʻia ʻo ia i ka pā e like me 500 mg metformirn + 50 mg sitagliptin 2 mau manawa i ka lā. ʻOiaʻiʻo, no kēia lāʻau lapaʻau, e like me kekahi mea'ē aʻe, aia nā ʻokoʻa ʻokoʻa. Manaʻo ia ʻaʻole pono e nā mea maʻi me ka maʻi type type 2 e lawe aku i kēia lāʻau lapaʻau i nā mea he ʻoi aku ma mua o 2000 mg o ka metformin a me 100 mg o sitagliptin.

Ke keu

ʻO ia nō hoʻi, pono e lawe i kēia lāʻau lapaʻau i ke ʻano like me ke ʻano he kauka i kau ʻia. ʻAʻole hiki ke ʻae ʻia nā hōkū o Yanumet. ʻO Sitagliptin, ʻoiai i kahi lawa nui, ʻaʻole maʻamau ia e hoʻopilikia maoli i ke kino o ke kanaka. No ka laʻana, ua loaʻa he wai ka manaʻo o 800 mg o kēia mau mea i hoʻonaninani maikaʻi ʻia e nā kānaka. ʻO ka mea pōʻino, ʻaʻole i ʻike ʻia ka nui o ka sitagliptin nui i pili i ke kino o ke kanaka, ʻoiai ʻaʻole i hana ʻia nā haʻawina like.

Ua manaʻoʻiʻo ia he mea hikiʻole ke metformin, ʻaʻohe naʻe he hiki. I kēia hihia, hoʻomohala paha ka mea maʻi i ka hypoglycemia. Eia kekahi, alakaʻi ka nui o nā metformin i ka hoʻomohalaʻana i ka hoʻomehana lactic acidosis. ʻO ka mea pōʻino, hoʻomaʻa pinepine kēia i - i 32% o nā hihia.

Ka lactic acidosis ua kapa ʻia kahi hoʻopiʻi kino weliweli, kahi hoʻohālikelike ʻia ka pale kaulike-kumu i ke kino o ke kanaka. I loko o nā kūlana koʻikoʻi, lilo kēia ʻano pathological i waena o nā mea ʻē aʻe, ke kumu o ka huhū ʻana o ka naʻau. Ma hope iho, hiki i ka lactic acidosis ke alakaʻi i ka hāʻule a me ka anurea, a laila hiki i ka hyperlactacidemic coma.

Kōkua i ka lactic acidosis

Ma kahi o kahi hoʻopiʻi like ʻana, pono e lawe wikiwiki nā mea e hoʻopakele ai i ka mea maʻi. E kōkua i ka mea maʻi me ka lactic acidosis ma ka hoʻopuka ʻana ma o ka hoʻoponopono ʻana i kahi 4% a i ʻole 2.5% hopena pākuʻi sodium bicarbonate. ʻO ka nui loa o kēia lāʻau lapaʻau ka manaʻo ʻia o 2000 ml i kēlā me kēia lā. Eia kekahi, me ka lactic acidosis, "pōkole" hiki i ka lāʻau lapaʻau e hoʻohana ai no ka mālama i nā mea maʻi, e hoʻohana ana i ka hoʻomākaukau ʻana o craboxylase, ka hoʻonā ʻana o ka reopoiliglukin, kahe koko, a me ka heparin.

Hiki ke ʻike ʻia kahi pōpilikia lactic acidosis ma lalo o ke kiʻi. "Janumet" a me nā mea hoʻohālike o kēia lāʻau lapaʻau me ka ʻano like ʻole a me nā ʻano like ʻole e lawe ʻia, ka mea, pono wale nō i nā dosages a ke kaukaukau ʻana e ke kauka.

He aha nā lāʻau lapaʻau e hiki ke hoʻonāwaliwali i ka hopena o ka lawe ʻana iā "Yanumet"

ʻAʻole kōkua ʻia kekahi mau lāʻau i ka manawa like me kēia lāʻau lapaʻau. No ka nāwaliwali i ka hopena o kēia ahe (metformin) hiki, no ke ʻano:

thiazide a me nā ʻano ʻē aʻe i ka diuretics,

ʻO nā hormones thyroid

I waena o nā mea ʻē aʻe, ua manaʻo ʻia ʻo ia ʻo Yanumet pono i hiki ke hoʻololi i ka hopena o kekahi mau lāʻau lapaʻau ma ke kino o ka mea maʻi. Hoʻia kēia mau mea, no ka hoʻohālike:

ʻAʻole ia e hāʻawi i ke hoʻohana ʻana i ka hui ʻana o "Yanumet" me kēia mau lāʻau lapaʻau. Inā hoʻoholo ʻia kēlā mea e pono ai, pono e hana ma lalo o ka mākaʻikaʻi paʻa o ke kauka hele mai.

Hōʻikeʻike i nā mea maʻi e pili ana i ka lāʻau lapaʻau

Loaʻa i ka poʻe me ka maʻi maʻi lā e pili ana i kēia lāʻau lapaʻau. Hoʻokomo ka poʻe maʻi i nā pono o kēia lāʻau ma ka mua, ʻoiaʻiʻo, ka hopena o kāna hana. No nā makahiki he nui, hiki i nā mea maʻi ke lawe i kēia lāʻau lapaʻau, e like me nā mea ʻē aʻe i ʻōlelo ʻia no ka maʻi maʻi. ʻO ka haʻalele ʻole o nā hoʻokaʻina o ke kō koko koko no ka manawa lōʻihi me ka hoʻohana kūpono - no kēia kumu, ma ka Pūnaewele, aia nā loiloi maikaʻi loa e pili ana i ka lāʻau lapaʻau ʻo Yanumet.ʻO nā mea kikoʻī o kēia lāʻau lapaʻau, me ka ʻokoʻa ʻole o kekahi mau mea ʻē aʻe, akā, ka mea maʻamau, ʻaʻole ia e hāʻawi i kahi hopena i haʻi ʻia.

Eia kekahi, ʻo nā mea i hopo ʻole ʻia o kēia lāʻau lapaʻau me ka loaʻa ʻana o ka hopena maikaʻi ʻole i ka puʻuwai. He mea pōʻino kēia, ʻo ka hapa nui o nā lāʻau lapaʻau i hoʻohana ʻia i mua o ke kaohi o ke kō o ke kō, he mea hoʻohui, ʻaʻole naʻe hiki iā lākou ke kaena. Eia kekahi, ʻo ka pono ʻole o ka Yanumet, e like me ka poʻe maʻi he nui, ʻaʻole ia e hoʻemi i ka pancreas.

Hoʻomaopopo kekahi mau mea maʻi, ma waena o nā mea ʻē aʻe, ʻo ka hoʻohana lōʻihi ʻana o kēia lāʻau lapaʻau e alakaʻi wale ana i ka lilo o ka momona. ʻO kēia, ʻoiaʻiʻo, hiki ke kiʻi ʻia i ka pono o Yanumet. Ma Lūkia, nā analogues o kēia lāʻau lapaʻau me ka loaʻa like me ka ʻike like, ʻoiaʻiʻo, e paʻakikī loa.

ʻAʻohe hoʻomaʻamaʻa maʻamau i kēia lāʻau lapaʻau, hoʻopaʻi ʻia e nā loiloi o ka poʻe me ka maʻi maʻi. ʻOiai paha wale nō ka hilahila o kēia lāʻau lapaʻau, e like me ka poʻe maʻi, ʻo ia kona kumukūʻai kiʻekiʻe. ʻO ka mea pōʻino, ʻaʻole o ka poʻe āpau i hiki ke lawe i kēia lāʻau lapaʻau, pōʻino.

Hōʻikeʻike i nā kauka e pili ana i ka lāʻau lapaʻau

ʻO nā kauka, e like me nā mea maʻi iā lākou iho, e noʻonoʻo iā Yanumet he lāʻau lapaʻau maikaʻi loa. Kuhi pinepine nā kauka iā lākou i kā lākou poʻe maʻi me ka maʻi diabetes type 2. Ma kahi o ka hopena o ka hana, ka poʻe loea, e like me ka poʻe maʻi iā lākou iho, e pili pū ana i nā pono no ka hoʻohana ʻole ʻia ʻana o kēia lāʻau lapaʻau ka mea, ʻaʻole i like me nā mea like ʻole like ʻole, ka mea like ʻole i nā ʻano like ʻole. ʻO ia ke kumu he maikaʻi loa nā loiloi e pili ana iā Yanumet mai nā kauka he nui ma ka Pūnaewele. Nā huahana a me nā hili no kēia lāʻau lapaʻau ma ke kino o ka mea maʻi, e like me nā kauka, he mau hopena ʻoi aku ka maikaʻi. Hoʻololi iā Yanumet mai nā lāʻau lapaʻau ʻē aʻe no kēia kumu, pinepine pinepine nā kauka o ko lākou poʻe maʻi.

Ma muli o ka loaʻa ʻole o kēia lāʻau lapaʻau i ka hopena koʻikoʻi o ka hoʻomohala ʻana, no ka laʻana, hypoglycemic syndrome, ʻo ia nō, loaʻa pū ka loiloi maikaʻi mai nā kauka. He maʻalahi ke kaʻina o "Yanumet" e hana i kēia mea e ʻoi loa e kiaʻi.

ʻOiai ka leʻomaʻo āpau, kokoke loa ka lāʻau, ʻaʻole e aʻo ka poʻe loea i ka lāʻau lapaʻau ponoʻī me ka hoʻohana ʻana i kēia pono hana. Pono ke koho pono i nā wahi o kēia lāʻau lapaʻau e nā kauka. ʻO kēia wale nō, ʻaʻole loaʻa ka hopena o ka lāʻau lapaʻau i ke kino o ka mea maʻi a hana i ka hana maʻalahi loa.

Pehea e mālama ai

I loko o kahi kīhāpai "Yanumet" a me nā mea hoʻohālike o kēia lāʻau lapaʻau, ʻelua a me nā haole, ma ka hapanui ke kūʻai wale ʻia aku nei ma ka lāʻau lapaʻau. ʻOiaʻiʻo, i mea e hana pono ai kēia lāʻau i ka maikaʻi inā pono e kāohi i ke kiʻekiʻe o ke kō i loko o ke koko, ma waena o nā mea ʻē aʻe, e mālama pono. E mālama i kēia lāʻau lapaʻau, e like me ka hapa nui o nā lāʻau lapaʻau, pono i kahi wahi pōʻeleʻele. Ke manaʻoʻiʻo ia e hoʻokō ʻo Yanumet i kāna mau waiwai inā ʻaʻole i piʻi ka umu i kahi o +25 ° C. No laila, i ka manawa hōʻina i nā lā wela loa, pono e hoʻomele nā ​​kīnā.

ʻOiaʻiʻo, pono ʻoe e mālama i kēia lāʻau lapaʻau ma ke ʻano o nā keiki a, inā, ʻaʻole, ʻaʻole hiki i nā holoholona ke hiki ke komo. ʻO 2 mau makahiki mai ka lā i hoʻopuka ai ka ola o ka noho o ka lāʻau "Yanumet". Ma hope o kēia manawa, ʻaʻole ʻae ʻia ia lāʻau lapaʻau e hoʻohana pono e mālama i nā kaila o ke koko. Ma hope o 2 mau makahiki mai ka lā i hoʻokuʻu ʻia ai, pono e hoʻokuʻu ʻia i ka lāʻau lapaʻau.

Yanumet - nā ʻōlelo aʻoaʻo no ka hoʻohana, nā kumu kūʻai, nā loiloi a me nā analog

ʻO Yanumet kahi hui o ka lāʻau hypoglycemic waha i hoʻohana ʻia i ka mālamaʻana i ka mellitus non-insulin-dependence.ʻO ka lawe ʻana i ka lāʻau lapaʻau e kōkua i ka mālama ʻana i ke kaʻe o ka glucose koko maʻamau, keʻae i ka holomua o ka maʻi a hoʻomaikaʻi i ke ʻano o ke ola no nā maʻi.

E hoʻokuʻu i nā palapala a me ka ʻano

Loaʻa ia ka lāʻau lapaʻau ma ke ʻano o nā papa oblong me kahi papa biconvex, i uhi ʻia me ke kiʻi enteric o ke aniani ʻulaʻula, a ʻulaʻula a i ʻole ʻulaʻula (hilinaʻi i nā kākā). Hoʻopaʻa ʻia ka lālani i nā pūʻulu blister o 14 mau ʻāpana. Mai ka 1 a he 7 paha ua hoʻonoho ʻia i loko o kahi kāʻei o nā pepa mānoanoa.

ʻO nā mea hana a Yanumet kahi sitagliptin ma ke ʻano o ka phosphate monohydrate a me ka metformin hydrochloride. ʻO ka sitagliptin i ka mākaukau mau like - 50 mg. ʻO ka hapa iki o ka metformin hydrochloride e loli a 500, 850 a i ʻole 1000 mg i ka papa pā.

E like me nā mea kōkua, aia ʻo Yanumet ka lauryl sulfate a me ka sodium stearyl fumarate, povidone a me MCC. Hana ʻia ka papa pālani mai ka macrogol 3350, polyvinyl ka ʻona, titanium dioxide, ʻulaʻula a me ka ʻio hāhi kahe.

Hoʻopaʻa ʻia ka lālani i nā pūʻulu blister o 14 mau ʻāpana.

ʻO ka lāʻau lapaʻau ka mea hoʻohui hui nona nā huahana ikaika i hoʻohui i ka hopena hypoglycemic hoʻohui (kōkua) me ke kōkua ʻana i nā mea maʻi e pili ana i ka maʻi diabetes mellitus type II e mālama i nā pae glucose maʻamau.

ʻO Sitagliptin, kahi ʻāpana o ka lāʻau lapaʻau, he mea koho ākea maikaʻi loa o ka dipeptidyl peptidase-4.

I ka hoʻāʻo ʻana, hoʻonui ʻia e 2-3 mau manawa i ka ʻike o ka ponaide-like peptide-1 a me ka peptide insulin-e hilinaʻi nei i ka glucose - nā hormon e hoʻoikaika i ka hana o ka insulin a hoʻonui i kāna hilo i loko o nā puna o ka pancreas.

Hāʻawi ka Sitagliptin iā ʻoe e mālama i ke kōpaʻa koko gula maʻamau i ke ao a pale i ka hoʻomohala ʻana o ka glycemia ma mua o ka ʻaina kakahiaka a ma hope o ka ʻai ʻana.

Hoʻohana ʻia ka hana o sitagliptin e ka metformin, he mea hypoglycemic pili i ka biguanides, kahi e hoʻemi ana i ke kahe o ke kō i loko o ke koko ma o ka hoʻokau ʻana aku i ka 1/3 o ke kaʻina hana o ka glucose i loko o ka ate.

Eia kekahi, i ka lawe ʻana i ka metformin i nā mea maʻi me ka diabetes mellitus type 2, he nui ka emi ʻana o ka hōʻomo ʻana o ka glucose mai ka ʻōpū o ke kūwili ʻana, kahi nui o ka hoʻonaninani ʻana i nā io o ka insulin a me ka hoʻonui ʻana i ke kaʻina o ka hoʻowalewā o ka waikawa momona.

Lapaʻau lāʻau

ʻO ka paona plasma kiʻekiʻe loa o ka sitagliptin i ʻike ʻia i nā hola 1-4 ma hope o ka hoʻomoʻa waha ʻana i kekahi maʻa hoʻokahi, metformin - ma hope o 2 mau hola. ʻO ka bioavailability o nā mea hana ikaika ke hoʻohana nei iā Yanumet ma kahi ʻōpū ʻole he 87% a 50-60%, kēlā.

ʻO ka hoʻohana ʻana o ka sitagliptin ma hope o ka ʻaina ʻaʻole ia e hoʻopilikia i ka hana ʻia ʻana mai ka papa hana ʻole. ʻO ka hoʻohana like ʻana o ka metformin me ka meaʻai ka hoʻemi ʻana i kona helu hāpili a hoʻēmi i ka hoʻoliʻelima ʻana i ka plasma e 40%.

Ka hele ʻana o ka sitagliptin e hele nui me ka urine. ʻO kahi ʻāpana liʻiliʻi o ia mea (ma kahi o 13%) e waiho i ke kino me nā mea i hoʻopili i ka ʻōpū. Hoʻopau piha ʻia ʻo Metformin e nā keiki.

Hoʻopau piha ʻia ʻo Metformin e nā keiki.

Nā hopena hopena o Yanumet

I ka wā e lawe ai i ka lāʻau lapaʻau, hiki i ka mea maʻi ke hōʻemi i nā hopena kūpono ʻole e hoʻonāukiuki ʻia e ka sitagliptin a me ka metformin. Inā hele lākou, pono ia e pale iki aku i ka lāʻau hou a kipa i ke kauka i ka hiki koke.

I ka hihia o nā hopena hopena, pono e pale i ka lāʻau hou a kipa aku i ke kauka i ka hiki.

ʻŌpala Gastrointestinal

ʻO nā hopena ʻino loa mai ka ʻōnaehana o ka digestive ʻike pinepine ʻia i ka hoʻomaka mua o ka maʻi. Hoʻopili kēia i ka ʻeha ma ka gastrointestinal tract kiʻekiʻe, nausea, ka luaʻi, ka hoʻonui ʻana i ka mīkini i loko o nā ʻōpū, ʻīwī, a maʻi constipation. ʻO ka lawe ʻana i nā paila me ka meaʻai e hiki ke hōʻemi i kā lākou hopena maikaʻi ʻole ma ka papa hana o ka kūnao ʻana.

I ka poʻe maʻi e loaʻa ana ka mālama ʻana me Yanumet, ʻo ka hoʻomohala ʻana o ka pancreatitis (hemorrhagic a necrotizing paha), kahi e hiki ai ke make, ʻaʻole i haʻalele ʻia.

Mai ka ʻaoʻao o ka metabolism

Inā koho ʻole ʻia ka dosage, hiki i ka mea maʻi ke loaʻa i ka hypoglycemia, kahi i ka emi nui o ke kō o ke koko. ʻO ka manawa, ka lawe ʻana i ka lāʻau lapaʻau hiki ke alakaʻi i ka lactic acidosis, ka mea e hōʻike ana iā ia iho i loko o ke ʻano o ka hoʻemi ʻana o ke kaomi a me ke ʻano o ke kino, ʻeha ma ka ʻōpū a me nā ʻōpū, nā maʻi ʻālunu, nāwaliwali a me ka hiamoe.

Mai ka pūnaehana cardiovascular

Hoʻomaʻamaʻa maikaʻi ʻia ka lāʻau e nā poʻe e loaʻa ana i nā maʻi o ka puʻuwai a me nā kīʻaha koko. I kekahi manawa, ʻike paha lākou i ka emi ʻana o ka puʻuwai puʻuwai, e ala ana ma ka hopena o ka maʻi lactic acidosis.

Hoʻomaʻamaʻa maikaʻi ʻia ka lāʻau e nā poʻe e loaʻa ana i nā maʻi o ka puʻuwai a me nā kīʻaha koko.

Me ka hoʻomanawanui ʻole o nā kūloko i nā mea i hoʻomohala ʻia i ka lāʻau lapaʻau, hiki i ke kanaka ke hoʻomohala i nā hopena kūlohelohe i ke ʻano o ka urticaria, kauā a me ka rashes ma ka ʻili. Ke mālama nei me Yanumet, ʻaʻole mālama ʻia ka nui o ka ʻāʻī o ka ʻili, nā meʻa o mucous a me ka kiko o subcutaneous, ʻo ia hoʻi ka mea e ola nei.

Hoʻohana i ka wā hāpai a me ka lactation

ʻAʻole ʻawaʻī ka lāʻau lapaʻau i ka wā e lawe ana i kahi keiki, ʻo ka ʻike ma o kona palekana i kēia manawa ʻaʻole ʻike. Inā he wahine hāpai i ka mālama ʻana iā Yanumet a lilo paha i hoʻolālā e hana i kēia, pono ʻo ia e kāpae i ka lawe ʻana a hoʻomaka i ka maʻi insulin.

ʻAʻohe kūpono o ka hoʻohana ʻana i ka lāʻau me ka umauma.

ʻAʻohe kūpono o ka hoʻohana ʻana i ka lāʻau me ka umauma.

Koho o Yanumet i na keiki

ʻO nā noiʻi e hōʻoia ana i ka palekana o ka lāʻau lapaʻau i nā keiki a me nā ʻōpio, ʻaʻole i lawe ʻia, no laila, ʻaʻole pono e kuhikuhi ʻia i nā poʻe maʻi ma lalo o ka makahiki o 18.

No ka mea ua hoʻōla ʻia nā mea ikaika o Yanumet i loko o ka mimi, a ma ka wā kahiko, ua emi ka hana excretory o nā pēpē, pono e kuhikuhi pono i ka lāʻau lapaʻau i nā kānaka ma mua o 60 mau makahiki he nui.

Hoʻopili pū me nā lāʻau ʻē aʻe

ʻO ka hui pū ʻana o ka lāʻau me nā diuretics, glucagon, oral contraceptives, phenothiazines, corticosteroids, isoniazid, calcium antagonists, nicotinic acid a me thyroid hormone alakaʻi i ka nāwaliwali o kāna hana.

Hoʻonui ʻia ka hopena hypoglycemic o ka lāʻau ke hoʻohana pū ʻia me nā lāʻau anti-inflammatory non-steroidal, nā MAO a me ACE inhibitors, insulin, sulfonylurea, oxytetracycline, clofibrate, acarbose, beta-adrenergic blocking agents a me cyclophosphamide.

Hoʻolaha ka waipuna

Lā ʻia ka inu ʻawaʻī i ka wā o ka mālama ʻana me Yanumet.

ʻO ka analogue hoʻonohonoho i ka lāʻau o Valmetia. Hana ʻia kēia lāʻau lapaʻau i ka palapala papa a he ʻano mana a me ka dosage e like me Yanumet. Eia kekahi, ʻo ka lāʻau lapaʻau ke koho ikaika aku - Yanumet Long, aia ka 100 mg o sitagliptin.

Ma ka haʻalele ʻana i kahi hopena therapeutic mai Yanumet, hiki i ke kauka ke kuhikuhi i nā kumuhana hypoglycemic i ka mea maʻi, i hui pū ai ka metformin me nā mea maʻi hypoglycemic ʻē aʻe. Aia kēia mau lāʻau lapaʻau:

• Avandamet
• Amaril M,
• Douglimax
• Galvus
• Wokanamet,
• ʻO nā Glucovans, etc.

ʻO ke aʻo ʻia ʻo Yanumet

ʻO ka lāʻau kōkōʻai - Amaril

ʻLelo a nā kauka e pili ana iā Yanumet

Sergey, 47 makahiki, endocrinologist, Vologda

No nā mea maʻi me ka non-non-insulin-dependence, kakau pinepine wau i kēia lāʻau lapaʻau, no ka mea ua hōʻoia ʻia kā kona hopena i kēia lā. Kāohi ʻo ia i ka glucose a hoʻomaʻamaʻa ʻaʻole ia i hoʻopuka i nā hopena ʻaoʻao ʻoiai me ka lōʻihi o ka lāʻau.

ʻO Anna Anatolyevna, he 53, mau makahiki endocrinologist, Moscow

Manaʻo wau i ka mālama ʻana me Janumet no nā poʻe maʻi hiki ʻole i hiki ke hoʻololi i kā lākou koko koko me Metformin wale nō.ʻO ka hoʻohui paʻakikī o ka lāʻau lapaʻau e kōkua i ka maikaʻi o ka hoʻomohala ʻana i nā hōʻailona glucose.

Ke makaʻu nei kekahi poʻe maʻi e lawe i ka lāʻau lapaʻau ma muli o ka loaʻa mai o ka hypoglycemia, akā ua hōʻike mua nā noiʻi like ʻole ka like o ka mea e hiki mai ana ma waena o ka poʻe i loaʻa i nā paila a me ka placebo.

A eia kēia ʻaʻole ka hopena o ka lāʻau lapaʻau i ka hoʻomohala ʻana i ka maʻi hypoglycemic syndrome. ʻO ka mea nui, ʻo ke koho i ke ʻano kūpono.

Pono e mālama ʻia ka lāʻau lapaʻau i nā kānaka ma mua o 60 mau makahiki.

Nā Hōʻike Hoʻomaʻi

Lyudmila, 37 makahiki, Kemerovo

Ua hoʻomaka wau e mālama me Janomat i hoʻokahi makahiki. Lawe au i ka palena haʻahaʻa o 50/500 mg i ke kakahiaka a me ke ahiahi. No nā mahina 3 mua o ka mālama ʻana, ʻaʻole hiki wale nō ke kaʻi aku i ka maʻi ma lalo o ka kaohi, akā, e nalowale hoʻi he 12 kg o ka nui o ke kaumaha. Hoʻohui wau i ka lāʻau lapaʻau me ka meaʻai a me ka hana kino. I kēia manawa uaʻoi aku ka maikaʻi ma mua o ka mālama ʻana.

Nikolay, 61 makahiki, Penza

Ua hoʻomaʻa ʻo ia no ka inu ʻana iā Metformin no ka maʻi diabetes, akā ua lūlū ʻo ia ke kōkua. Ua ʻōlelo ka poʻe endocrinologist e mālama aku iā Yanumet a ʻōlelo a lākou i kēia lāʻau lapaʻau ke kaha ikaika aku i ka mea aʻu i lawe ai ma mua. Ua lawe wau iā ia i mau mahina 2 mau, akā ua hoʻonui ʻia ke kō. ʻAʻole wau i ʻike i kahi hopena maikaʻi mai ka mālama ʻana.

Yanumet 1000 50: kumukūʻai, loiloi lāʻau lapaʻau, analogs o nā papa

Hiki i ka lāʻau lapaʻau no ke ʻano maʻi mellitus type 2 ke loaʻa pū me ka lāʻau lapaʻau hoʻokahi a i ʻole kahi lāʻau lapaʻau paʻakikī.

ʻO Yanumet, ma ke ʻano he antidiabetic agent, he lāʻau lapaʻau me ʻelua mau mea kanu ikaika, no laila ʻo ka lawe ʻana i hoʻokahi papa hiki ke hoʻololi i ka pono e hoʻohana i nā lāʻau lapaʻau.

I kēia manawa, uku nui nā lāʻau lapaʻau i loko o nā lāʻau lapaʻau ma Rūsia. Akā, e like me nā loea loiloi, ʻo kā lākou ʻoihana ke hōʻoia i kēlā kumukūʻai.

He aha ka mea hypoglycemic agent?

Hoʻokomo ʻia ka lāʻau Yanumet i ka hui o nā lāʻau lapaʻau me ka hopena hypoglycemic. ʻO ia ke kumu, hōʻike pinepine ʻia no ka mellitus o ka maʻi diabetes mellitus o kahi ʻano kūʻokoʻa insulin.

Hoʻonui ʻia kāna kūlana e nā mau mea ikaika e lilo i ka wahi o ka lāʻau lapaʻau.

ʻO ka ʻāina kumu o Yanumet ka United States oʻAmelika, e wehewehe ana i ke kumukūʻai nui o nā lāʻau (a hiki i ʻekolu tausani mau rubles, e pili ana i ka dosage).

Hoʻohana ʻia nā papa Janumet i loko o kēia mau hihia:

• e hōʻemi i ke kahe o ke koko, inā paha ke kau nei ka meaʻai i ke kino me ka hana kino e hōʻike i ka hopena maikaʻi ʻole.
• inā ʻo ka monotherapy e hoʻohana wale nei i kekahi mea ikaika no ka lawe ʻana i ka hopena i makemake ʻia,
• Hiki ke mālama ia e like me kahi lā paʻakikī i hui pū ʻia me nā derivatives o sulfrnylurea, insulin therapy a i ʻole nā ​​antagonist o PPAR-gamma.

Ke loaʻa nei ka lāʻau lapaʻau i kāna hoʻonohonoho ʻana i hoʻokahi manawa ʻelua mau hana ikaika e loaʻa ka hopena hypoglycemic:

1. ʻO Sitaglipin kahi mea i hui ʻia o ka hui o ka hoʻonaninani DPP-4, ka mea, me ka hoʻonui i ke kō o ke koko, hoʻowalewale i ka synthesis a me ka huna ʻana o nā insulin e nā pancreatic beta cells. Ma muli o kēia kaʻina hana, aia ke emi ʻana o ke kō i nā hoʻohuihui gula i ka nui ole.
2. ʻO ka Metformin hydrochloride he mea moho o ka hui biguanide o nā kolu o ka lālani, ka mea i hāʻawi ʻia i ka pale o ka gluconeogenesis. ʻO ka hoʻohana ʻana i nā lāʻau lapaʻau e pili ana i ka mea e hoʻoulu ai i ka glycolysis, kahi e hoʻomaikaʻi ai i ka holomua o ka glucose i nā hua a me nā kiko o ke kino. Eia kekahi, aia kahi wīwī i ka lawe ʻana o ka glucose i nā sela ʻeha. ʻO ka pōmaikaʻi nui o ka metformin ka mea ʻaʻole ia e lilo i ka emi o ka hōʻemi i nā pae glucose (ma lalo o nā pae maʻamau) a ʻaʻole i alakaʻi i ka hoʻolālāʻana o ka hypoglycemia.

Hiki i ka nui o nā lāʻau lapaʻau ke hiki mai ʻelima haneri a i hoʻokahi tausani milligrams o kekahi o nā mea hana - metformin hydrochloride.ʻO ia ke kumu, hāʻawi ka lāʻau lapaʻau hou i nā mea maʻi i nā papa e like me kēia:

ʻO ke kiʻi mua i ka hoʻonohonoho o ka lāʻau lapaʻau e hōʻike ana i ka nui o ka sitaglipin o ka mea hana, ka lua e hōʻike ana i ka hiki o ka metformin. Hoʻohana ʻia nā mea kōkua.

1. ʻO ka cellulose Microcrystalline.
2. ʻO Povidone.
3. Sodium stearyl fumarate.
4. Sodium lauryl sulfate.
5. Ka waiʻona Polvinyl, ka titanium dioxide, macrogol, talc, ka oxide iron (ʻo ka ʻōpū o ka hoʻomākaukau ʻana o ka papa i ia mau mea).

Mahalo i ka mea lapaʻau ʻO Yanumet (Yanomed) i hiki, ke hiki ke hoʻokō i ka pale ʻana o ka nui o ka glucoseagon, ka mea, me ka piʻi o ka nui o ka insulin, e alakaʻi ana i ka normalization o ka glucose i loko o ke koko.

Nā ʻōkuhi no ka hoʻohana ʻana i nā papa

ʻO ka kauka hele wale nō e mālama nei i ke ala o ke kaʻina pili ke kuhikuhi i ka mālama ʻana a me ke ʻano o ka lawe ʻana i ka lāʻau lapaʻau no nā poʻe maʻi.

Pēlā i paʻa ai ka hoʻomākaukau ʻana no Yanumet ʻelua mau manawa o ka lā i ka wā o ka pāʻina (ma ke kakahiaka a me ke ahiahi), inu ʻia nā wai nui.

E hōʻike i nā ʻōkuhi no ka hoʻohana ʻana, ʻo ke ʻano mua o 500 mg metformin hydrochloride a me 50 mg sitaglipin pālua ʻelua o ka lā (hoʻokahi papa me ka liʻiliʻi liʻiliʻi).

Pono e hoʻoponopono hou ʻia me ka pālua o ka metformin.

Inā ma mua ka mea maʻi e hana i kahi papa lāʻau me ka hoʻohana wale ʻana i nā lāʻau lapaʻau e pili ana i ka metformin, a me kēia ʻano hana, ʻaʻole ia i lawe mai i ka hopena pono, e hoʻohana ʻia ka hoʻohana ʻana i ka lāʻau.

• ka hoʻohana ʻana i ka mana o ka metformin hydrochloride ma mua o ka mālama ʻana
• pono ka pae ʻana o kahi sitaglipin ma kahi o 100 mgꓼ
• ʻO ka nui o nā pā i nā lā ʻelua.

ʻO ka māhele o nā mea maʻi ma mua e hoʻohana ai i ka lāʻau lapaʻau e pili ana i nā lāʻau lapaʻau me nā sitaglipin wale nō e pono e hōʻeha i nā maʻi hou e like me ke ʻano penei:

1. I ʻelua mau manawa o ka lā, lawe ʻia ka lāʻau lapaʻau ma ka nui o 50 mg o ka sitaglipin a me 500 mg o ka metformin hydrochloride.
2. Ma hope mai, hiki ke hoʻonui i nā hewa i nā ʻāpana o hoʻokahi papa o Janumet 1000.

Inā hoʻohana ʻia kahi paʻa therapeutic paʻakikī me nā derivatives o sulfonylurea, e hoʻoholo nā mea i lalo iho nei i ka hoʻoponopono palena hana.

• kau ka hopena o ka metformin hydrochloride e pili ana i ka pae o ka hoʻomohala ʻana o ka pathology i ka mea maʻi
• ka 100 mg kaʻe ʻana o ka sitaglipin i 100 mg, hoʻokaʻawale ʻia i ʻelua pona
• ka helu o nā mea ikaika o nā derivatives o ka sulfonylurea e hoʻoholo e ka mea hele i ke kauka e pili ana i ke kiʻi o ka maʻi maʻi.

ʻO kekahi o nā ʻano lāʻau e hoʻokaʻawale i ka ʻai ʻana i nā mea inu ʻona, ʻoiai ua hoʻākāka ka ʻawaʻawa. ʻO ka hoʻohālikelike ʻana me nā lāʻau ʻē aʻe e pono me ka ʻae ʻana ma kahi loea.

I ka hihia o kahi overdose, hoʻomohala paha ka lactic acidosis.

E hoʻopau iā ia, ua hoʻokipa ʻia nā mea maʻi a lawe i nā ʻano ma hope o ke ʻano lapaʻau - therapy hōʻailona, ​​hemodialysis.

I nā hihia hea i pāpā ʻia ai ke hoʻohana ʻana i kahi mea hypoglycemic agent?

Ma mua o ka hoʻomaka ʻana i ka lapaʻau therapeutic, pono ʻoe e heluhelu ponoʻī i ka helu o nā contraindications i kuhikuhi i nā ʻōlelo aʻoaʻo.

Eia kekahi, pono e kūkā me kāu kauka e pili ana i ka hoʻohana ʻana i ka lāʻau.

E like me nā lāʻau he nui, ʻaʻole hiki ke hoʻohana ʻia ʻo Yanumet i kekahi mau hihia.

ʻO ka mea mua, pāpā ʻia ke kaʻina papa papa inā loaʻa nā ʻano.

1. Aia kekahi kiʻekiʻe hoʻonui o ka maʻa i ka mea maʻi i hoʻokahi a keu paha mau mea o ka lāʻau lapaʻau.
2. ʻO nā pilikia me ka hana maʻamau o nā pēpē, a me ka hōʻikeʻana i nā kūlana i hiki ke hoʻopōʻino ʻia i kona poho. Hoʻopili kēia me ka dehydration, ka papa o nā pathologies infectious pathological, a me kahi kūlana o ka pīhoihoi.
3. Hiki i nā kūlana ke hopena i ka hypoxia kiko.
4. Heha ka maʻi ʻeha a me kona ʻano ʻole.
5. I ka wā o ka waiʻonaʻona.
6. Acute a acethabose kūwaho metabolic.
7. Maʻi molaʻi.
8. Ke ʻano hana i loko o ka insulin o ke kaʻina pili.