Kauʻikahi (Orlistat)

I kēiaʻatikala, hiki iā ʻoe ke heluhelu i nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau Orlistat. ^ E Ha yM. Hāʻawi i ka hoihoi mai ka poʻe kipa i ka pūnaewele - nā mea kūʻai o kēia lāʻau lapaʻau, a me nā manaʻo o nā loea lapaʻau e pili ana i ka hoʻohana ʻana iā Orlistat i kā lākou hana. ʻO kahi noi nui, ʻo ia ke hoʻoikaika ikaika i kāu mau loiloi e pili ana i ka lāʻau lapaʻau: kōkua ka lāʻau lapaʻau a ʻaʻole hoʻi i kōkua i ka hoʻopiʻi ʻana i ka maʻi, nā mea hoʻopiʻi a me nā hopena ʻaoʻao, ua ʻike ʻia, ʻaʻole i hoʻolaha ʻia e ka mea hana ma ka abstract. Nā kikoʻina o Orlistat ma ke alo o nā kikowaena hoʻonohonoho loina i loaʻa. Hoʻohana no ka mālamaʻana i ka momona, hōʻemi a me ka hoʻolilo ʻana i nā mea momona ma nā pākeke, nā keiki, me ka wā hāpai a me ka lactation. ʻO ka hiʻohiʻona o ka lāʻau lapaʻau.

Orlistat - pale kelehele. Ke lawe ʻia ma ka ʻōlelo maʻamau, mālama ana ka orlistat i ka lipemika a me ka pancreatic lipases. A ʻo kahi hopena, ke hoʻopau ʻia nei ka uha ʻole ʻana o ka ʻaʻa meaʻai a ua hōʻemi ʻia ko lākou komo ʻana mai ka digestive tract. Me ka hoʻohana pū ʻana i ka ʻōnaehana pilikia, alakaʻi i kēia hopena i ka emi ʻana o ke kaumaha o ke kino i nā mea maʻi me ka maʻi momona. ʻO Orlistat i hoʻohiki ʻole ʻia mai ka gastrointestinal tract a no laila ʻaʻole like kahi hopena resorptive.

Hōʻike

ʻO Orlistat + nā mea hoihoi.

Lapaʻau lāʻau

I loko o nā mea hana haole me ke kaumaha o ke kino a me ka momona, ua liʻiliʻi ka hopena o ka lāʻau i ka lāʻau. Ma hope o kahi ka hoʻokele waha hoʻokahi o ka lāʻau i loko o ka maʻa o 360 mg, ʻaʻole i hiki ke hoʻoholo ʻia i ka Orlistat i ka plasma, ʻo ia ka mea, aia ma lalo o ke ana o ka 5 ng / ml. ʻAʻohe mau hōʻailona no ka hoʻopili ʻana, e hōʻoia nei i ka liʻiliʻi o ka komo ʻana o ka lāʻau lapaʻau. Ma ka liʻiliʻi liʻiliʻi, hiki i ka orlistat ke komo i nā sela koko ʻulaʻula. ʻO ka hoʻokolokolo ʻana e ka ʻikepili i loaʻa i ka hoʻokolohua holoholona, ​​lawe ka metabolism o orlistat i ka nui ma ka paia o ka ʻōpū. Ua hōʻike ʻia nā haʻawina i loko o ka poʻe me ka maʻamau a me ke kaupaona ʻana. Me nā kumukūʻai, kahi o ka 97% o nā lae i kāhea ʻia i nā lāʻau ua hoʻopau ʻia, me 83% i ke ʻano o orlistat i loli ʻole. ʻO ka nui o ka hoʻopiha ʻāpana a me nā mea āpau i hoʻopili ʻia me ka orlistat kahi i emi mai ka 2% o ka nui i lawe ʻia. ʻO ka wā e hoʻopau ai i ka lāʻau lapaʻau mai ke kino (me nā feces a me ka urine) ʻo 3-5 lā.

Nā Hōʻike

• hakahaka (i hui pū me ka moʻo kala kala momona).

E hoʻokuʻu i nā palapala

Nā Capsules 120 mg (i kekahi manawa i kuhi ʻia ʻia nā papa).

Nā ʻōkuhi no ka hoʻohana a me ka regimen

Lawe i ka 120 mg maʻamau ma kēlā me kēia papaʻai a i loko o hoʻokahi hola ma hope o ka ʻai ʻana, ma mua o 3 mau manawa i ka lā. Inā haʻahaʻa ka meaʻai i ka momona, hiki iā ʻoe ke skip i ka papa inoa orlistat.

Loaʻa ka hopena

• hoʻohemo ʻia mai ka momi,
• he ʻano hūnā
• kekahipi ʻo ke kino me kahi nui o ka hoʻokuʻu ʻana
• ʻūlū
• ʻaoa manuahi (steatorrhea),
• nā neʻe pinepine ʻana
• pono koi
• hiki ʻole ka huhū lahilahi.

Nā Hoʻohui

• ʻālaʻi melabsorption,
• cholestasis
• hypersensitivity iā Orlistat.

ʻŌpū a me ka lactation

Hoʻohana ʻia ʻo Orlistat me ka akahele loa i ka wā hāpai a me ka lactation.

I nā noiʻi o ka make huina o ka huaʻai i loko o nā holoholona, ​​ʻaʻole i mālama ʻia ka hopena teratogenic a me ka embryotoxic o ka lāʻau. I ka hiki ʻole o kahi hopena teratogenic i nā holoholona, ​​ʻaʻole pono ke ʻano he hopena like i loko o nā kānaka.

Hoʻohana i nā keiki

Nā ʻōlelo kikoʻī

Pono e noʻonoʻo i ka ulu a me ka paʻakikī o nā hopena ʻaoʻao e hoʻonui me ka hoʻonui ʻana i ka momona momona i ka meaʻai. Me ka hoʻohaʻahaʻa ʻana i ka momona o ka momona i ka meaʻai, ua emi ka hopena o ka hopena. Hōʻike ʻia i ka nui o nā momona i hoʻopau ʻia i kēlā me kēia lā i kau like ʻia ma luna o nā pāʻina a pau.

I ka wā o ka mālama ʻana, ma ka emi ʻana o ke kaumaha o ke kino, hiki ke hoʻomaikaʻi i ke ʻano o nā kaʻina o nā pathological pinepine i pili me ka obesity, a me ka hypertension arterial, maʻi mellitus, maʻi lipid metabolism.

Hoʻohui nūhou

Ua hōʻike ʻia ʻo Orlistat e hoʻemi i ka komo ʻana mai ka gastrointestinal tract o betacarotene, alpha-tocopherol.

ʻAʻohe mea i launa pū me ka amitriptyline, atorvastatin, biguanides, digoxin, fibrates, fluoxetine, losartan, phenytoin, oral contraceptives, phentermine, pravastatin, warfarin, nifedipine GITS (kūmole-gastrointestinal therapy system) a nibbutin ma waena o nā lāʻau lapaʻau). Eia nō naʻe, pono e nānā i ka hana o MNO me ka hoʻohui concomitant me warfarin a i ʻole nā ​​mea anticoagulants waha.

Me ka hoʻokolohua ʻōpiopio o nā lāʻau a foratat and antiepileptic, ua nānā ʻia nā hihia o ka hiki ʻana o nā paʻahao. ʻAʻole paʻa i kahi pilina kumu ma waena o ka hoʻomohala ʻana o ka make. Eia naʻe, pono e nānā pono nā mea maʻi no nā loli i hiki ke hele a i ʻole a i ʻole ka paʻakikī o ka ʻanikini maʻi.

Nā kūmole o ka lāʻau Orlistat

Hoʻololi nā kumu hoʻohālike o ka waiwai ikaika:

• Allie
• Xenalten
• Xenalten kukui,
• Xenalten Slim,
• Xenical
• Listata
• Listata Mini,
• Orlimax
• Paa Orlimax,
• Canon Kahuna
• Orsoten
• Orinotin Slim.

Nā kūmole no ka hopena therapeutic (kālā no ka mālamaʻana i ka momona):

• Aknekutan,
• ʻO ka pale kaulua
• Palapala kalapona
• Garcilin
• Garcinia forte
• Ke gula
• Kai hōʻoluʻolu
• L? ʻAe kikohoʻe kālā,
• Kawaiʻu
• Koi kūlohelohe,
• ʻO Dr. Theiss Nova Gambar,
• Kahiʻo
• Coenzyme Q10 me Ginkgo,
• Lamisplat
• Lindax,
• Hoʻololi Magnesium,
• Meridia
• Metformin
• Mukofalk,
• Normoflorin
• Oxodoline,
• Orsoslim
• ʻO Reduxin
• Polysorb
• Sibutramine,
• Kuilohi,
• Amping,
• Trimex,
• Phenotropil,
• Figurin
• Fitolaks,
• Hōʻailona,
• Ola Hood,
• Hoodia Slim
• Kika Pūnaewele Citrimax Plus,
• Citrosept
• Shugafri.

ʻĀpana Pharmacological

Lapaʻau lāʻau

ʻO kahi mea paʻa paʻa o nā lipine gastrointestinal. Mālama ʻo ia i kahi pilina covalent me ka pae o ka serine ikaika o ka lipric a me ka pancreatic lipases ma ka lumen o ka ʻōpū a me nā ʻili liʻiliʻi. Ua aneane kekahi kaila eneuee i ka hiki ke wawahi i nā momona momona i ke ʻano o ka triglycerides (TG). ʻAʻole pākia nā TGs maikaʻi ʻole, a ʻo ka hopena o ka hōʻemi ʻana i ka calorie intake e alakaʻi i ka emi ʻana o ke kaumaha o ke kino. Hoʻonui ka hoʻonuiʻana i ka momona i nā hana 24-48 mau hola ma hope o ka nānā ʻana. Hāʻawi i kahi mālama pono o ke kaumaha o ke kino, hōʻemi i ka momona depot.

No ka hōʻike o ka hana, ʻaʻole pono ka ʻōnaehana o ka orlistat; ma ka ʻōlelo lapaʻau ʻia ʻoi ʻia (120 mg 3 mau manawa i kahi lā), ke pale ʻia nei ia i ka loaʻa ʻana o nā momona i loaʻa mai ka ʻai ma kahi o 30%.

Lapaʻau lāʻau

He haʻahaʻa loa ka puʻu kikowaena, 8 mau hola ma hope o ke kauā ʻana, ʻaʻole i hoʻololi ʻia ka Orlistat i ke anelepine (ʻo ka manaʻo ma lalo o 5 ng / ml).

ʻO ka paku ʻōpiopio o ka orlistat ka mea liʻiliʻi. Ma hope o ka nānā ʻana i ka 360 mg o ka radioactively i hoʻopaʻa ʻia i ka 14 C-orlistat, ua hōʻea ka lele radioactivity i ka plasma ma hope o 8 mau hola, ua kokoke ke kikowaena o kahi orlistat ʻaʻole i hoʻololi ʻia a kokoke i ka palena o ka ʻike (ma lalo o 5 ng / ml). I loko o nā haʻawina therapeutic, i pili pū me ka nānā ʻana i nā tauira plasma i nā maʻi, nā orlistat i loli ʻole ʻia, ua hoʻoholo ʻia i ka sporadically i loko o ka plasma, a he haʻahaʻa loa kona mau kiko (liʻiliʻi ma lalo o 10 ng / ml), me nā hōʻailona ʻole e hōʻuluʻulu ʻia, ka mea e kūlike me ka liʻiliʻi o ka hoʻopio ʻana o ka lāʻau lapaʻau.

In vitro a ʻo orlistat ma mua o ka 99% kaomi ʻana i ka protein plasma, ʻoi loa me nā lipoproteins a me ka albumin. ʻO Orlistat ka minimally i komo i loko o nā kaila koko. Hoʻomili ʻia ia i ka pā o ka pā o ka gastrointestinal me ka hoʻokumu ʻana o nā metabolite i ʻole nā ​​ʻano pharmacologically M1 (hydrolyzed ʻehā līpone lactone ʻehā) a me M3 (M1 me ka pale o N-formylleucine mau koina). I kahi noiʻi i nā poʻe maʻi hānai e helu ana iā 14 C-orlistat, 2 metabolites, M1 a me M3, i helu no 42% o ka radioactivity plasma nui. Loaʻa ka M1 a me M3 i kahi apo beta-lactone wehe a hōʻike i ka hana hoʻoweliweli loa i nā lipases (hoʻohālikelike ʻia me orlistat, ʻo lākou ka 1000 a me 2500 mau manawa palupalu, kēlā). Hāʻawi ʻia i ka hana haʻahaʻa a me ka hoʻohaʻahaʻa haʻahaʻa o nā metabolites plasma (ma kahi o 26 ng / ml a me 108 ng / ml no M1 a me M3, kēlā, 2–4 mau hola ma hope o ka lawelawe ʻana o ka orlistat i nā pilala therapeutic), ua manaʻo ʻia kēia mau mea huakaʻi a i ʻole ka pharmacologically insignificant. ʻO ka metabolite nui M1 kahi pōkole T_1/2 (ma aneane 3 mau hola), ka lua o ka metabolite hou a hoʻolōʻihi (T_1/2 - 13.5 hola. I Na Manao Obese C_{ai ʻo ss} hoʻonui ka metabolite M1 (akā ʻaʻole M3) i ka hoʻohālikelike o ka dosis o orlistat. Ma hope o ka hoʻomālamalama waha hoʻokahi o 360 mg o 14 C-orlistat e nā mea maʻi me ke kaumaha kino kino a ke kaumaha nei i ka momona, ʻo ka hoʻokuʻu ʻana i ka orlistat non-absorbable ma loko o nā ʻōpū o ke ala nui o ka maʻa. ʻO Orlistat a me nā metabolites M1 a me M3 ua hoʻopili ʻia hoʻi me ka bile. Ma kahi o 97% o nā waiwai i hoʻopaʻa ʻia e ka leo radioactly i hoʻopili ʻia me nā mea kuku, komo 83% - i loli ʻole.

ʻO ka nui o ka hoʻopā ʻana o ka wahine holoʻokoʻa i ka radioactivity āpau me 360 ​​mg o 14 C-orlistat kahi i emi iho i ka 2%. ʻO ka manawa no ka hoʻopauʻana me nā feces a me nā urine he 3-5 lā. Loaʻa nā hana i loaʻa ai ka orlistat i nā mea like me nā mea maʻi me ke kaumaha o ke kino maʻamau a me ka momona. Ke pili ana i ka ʻike palena, T_1/2 Hoʻopili i nā orlistat i waena o 1-2 mau hola.

Nā hōʻikeʻike o ka lāʻau Orlistat

ka mālama ʻana i ka momona, me ke komo ka hoʻemi ʻana a me ka mālama ʻana i ke kaupaona o ke kino, i hui pū me ka meaʻai haʻahaʻa.

ka hoʻemi ʻana o ka pilikia o ka loaʻa hou ʻana o ke kaumaha kino ma hope o kona hoʻoemi mua ʻana.

Ua hōʻike ʻia ʻo Orlistat no nā maʻi maʻi obese me kahi pūhaka lōlapa o ke kino (BMI) o ≥30 kg / m 2 a i ≥28 kg / m 2 i mua o nā mea ʻē aʻe i ka maʻi (maʻi, hypertension, dyslipidemia). (Ka helu a ka BMI: BMI = M / P 2, kahi ma M - nā paona kino, kg, P - kiʻekiʻe, m.)

ʻŌpū a me ka lactation

ʻO Orlistat ka contraindicated i ka wā hapai ma muli o ka nele o nā ʻike lapaʻau paʻa e hōʻoia nei i ka palekana o kona hoʻohana.

ʻAʻole i hoʻokūpaʻa ʻia i hala a Orlistat i loko o ka waiū umauma, a no laila, ʻaʻole kōkua ʻia ka hoʻohana ʻana o Xenalten ® i ka wā o ka ʻōpū.

Nā hopena hopena

Ua hoʻoholo ʻia ke alapine ʻoi aku ka hopena ma lalo nei e like me kēia: mau pinepine (> 1/10), pinepine pinepine ʻia (> 1/100, 1/1000, 1/10000, GIT: ka pinepine pinepine - ka hoʻokuʻu ʻaila mai loko o ka ʻōpala, ka hau me kahi nui o ka hoʻokuʻu ʻana, pono ke koi ʻana i ka loiloi, ka steatorrhea, nā ʻōpū o ka ʻōpū, nā kīwaha pale, nā ʻulaʻeha, ka ʻeha a i ʻole kaʻeha i ka ʻōpū.

Ma ke ʻano he kānāwai, he mau ʻoluʻolu a mau ke ʻano, he hanana ma ka manawa mua o ka mālama ʻana (ma nā mahina 3 mua. Hoʻonui ka nui o kēia mau ʻōpiopio me ka hoʻonui ʻana i nā momona momona i ka meaʻai. Pono e ʻike ʻia nā mea maʻi e pili ana i ka hiki ʻana o kēia mau hōʻino kino a aʻo i ka hoʻokaʻa ʻana iā lākou ma o kaʻai ʻana o ka ʻai, ʻo ia hoʻi e pili ana i ka nui o ka momona o loko. ʻO nā manawa pinepine - nā kīʻaha palupalu, hōʻeha a hōʻeha ʻole paha i ka rectum, fecal incontinence, bloating, huni hōʻeha, maʻi maʻi.

Mai ka pūnaehana hanu, umauma a me nā ʻōpū mediastinal: nā maʻi hāmeʻa pinepine loa ma mua o nā maʻi ʻeha, ʻoi aku ka haʻahaʻa o nā maʻi o ke ea.

Mai ka pānaʻi: līpī - heching, urticaria, rash, angioedema, bronchospasm, anaphylaxis.

Mai ka ʻōnaehana hoʻonāukiuki: pinepine pinepine - ʻeha.

Ma ka ʻāpana o ka ate a me ka pēpē biliary: ākea loa - hoʻonui i ka hana o ka transaminases a me ka phosphatase alkaline, hepatitis.

Mai nā pūpū a me ka maʻi urinary: pinepine ʻia nā maʻi ʻeha.

Nā ʻili: pinepine - flu, pinepine - dysmenorrhea, hopohopo, nāwaliwali.

Inā he ʻeha nā hopena ʻē aʻe i kuhikuhi ʻia i nā ʻōlelo mahele a i ʻole nā ​​hopena ʻē aʻe i ʻole i kākau ʻia i nā ʻōkuhi, pono ʻoe e hoʻomaopopo i kāu kauka.

Hoʻohui

ʻAʻole pili ʻo Orlistat i ka pharmacokinetics o ka ethanol, digoxin (i kauoha ʻia i ka pākahi hoʻokahi) a me ka phenytoin (i kauoha ʻia ma kahi hoʻokahi manawa o 300 mg), a i ʻole bioavailability o ka nifedipine (nā papa hoʻopiʻi paʻa). ʻAʻole hoʻopilikia ka Ethanol i ka pharmacodynamics (momona excretion me nā feces) a me ka hoʻolaha o ka systemic o orlistat.

Me ka hoʻohana pū ʻana o ka orlistat a me ka cyclosporine, e hōʻemi ʻia ka pae o ka hope ma ka plasma (ʻaʻole pono e lawe ʻia i ka orlistat a me nā cyclosporine e hōʻemi i ka manawa like, e hōʻemi i ka hopena o ka hōʻiliʻili lāʻau, pono e lawe ʻia ka cyclosporine i 2 mau hola ma mua a i ʻole 2 mau hola ma hope o ka lawe orlistat).

Me ka hana like o warfarin a i ʻole nā ​​anticoagulants kūlike me ka orlistat, e hoʻemi ana ka pae o ka prothrombin a i loli paha ka waiwai o ka hōʻike INR, no laila e pono ana ka nānā ʻana o INR. ʻO Orlistat ka hōʻemi ʻana i ka laweʻana o nā beta-carotene i nā kumuhana kai e 30% a pale i ka hoʻoli ʻana o ka vitamin E (ma ke ʻano o tocopherol acetate) ma kahi o 60%.

Hoʻonui ia i ka bioavailability a me ka hopena hypolipidemic o pravastatin, e hoʻonui ana i kona kao i loko o ka plasma e 30%.

Me ka hoʻokolohua hui ʻole me ka orlistat, ua hoʻemi ʻia ka ʻike ʻana o nā huaora A, D, E a me K A inā i ʻōlelo ʻia nā multivitamins, pono lākou e lawe ma kahi o 2 mau hola ma hope o ka lawe ʻana iā Xenalten ® a i ʻole o ka hiamoe.

Hiki i ka hōʻemi o ka momona ke hoʻomaikaʻi i ka hana metabolism i loko o nā mea maʻi me ka mellitus maʻi diabetes, ma muli o kahi e pono ai e hōʻemi i ka nui o nā lāʻau lapaʻau hypoglycemic waha.

ʻAʻole hoʻolako ʻia ka hoʻohana pinepine ʻana o ka acarbose ma muli o ka nele o ka ʻikepili ma nā lāʻau lapaʻau pharmacokinetic. Me ka hoʻohana pū ʻana me ka orlistat, kahi hoʻohaʻahaʻa i ka pae o ka amiodarone i ka plasma ma hope o ka pākuʻi ʻana hoʻokahi pā kaha. ʻO ka hoʻohana pinepine ʻana o orlistat a me amiodarone hiki wale nō i ka ʻōlelo noiʻi o ke kauka.

ʻO Orlistat hiki paha ke hoʻemi hūnā i ka bioavailability o nā mea i hoʻohālikelike ʻia i ka waha, hiki iā ia ke alakaʻi i ka ulu ʻana o kahi ʻōpala makemake ʻole ʻia. Hoʻomaopopo ʻia e hoʻohana i nā ʻano o ka mea maʻamau i ka hihia o ke ake o ka maʻi.

Nā pilina pili maʻi me ka digoxin, amitriptyline, phenytoin, fluoxetine, sibutramine, atorvastatin, pravastatin, losartan, glibenclamide, contraceptives oral, nifedipine, furosemide, captopril, atenolol a me ethanol.

Ke keu

ʻAʻole hōʻike ʻia nā hihia o ka overdose.

Hoʻokahi i hoʻokahi pākahi o 800 mg o orlistat a i kona mau helu he nui a hiki i ka 400 mg 3 mau manawa i ka lā no 15 mau lā e ka poʻe me ka paona kino a me nā hiʻona ʻaʻole i hui pū ʻia e nā hopena koʻikoʻi.

Inā ʻike ʻia ka overdose nui o ka orlistat, pono e nānā ka mea maʻi i nā hola 24. Wahi a nā noiʻi ʻana i nā holoholona a me nā kānaka, ʻo nā ʻōnaehana ʻōnaehana e pili ana me ka lipase-inhibiting o nā orlistat e wikiwiki e hoʻolilo hou i ka wikiwiki.

Nā ʻōlelo kikoʻī

I ka wā o ka mālama ʻana, pono ia e hahai i kahi kīʻaha hoʻemi haʻahaʻa, haʻahaʻa-calorie e ʻole ka nui o ke koena o ka 30% ma ke ʻano o nā momona a hoʻonui ʻia me nā huaʻai a me nā mea kanu.

Ma mua o ka koho ʻana i ka orlistat, pono e hoʻoholo ʻia nā kumu kūlohelohe, e like me ka hypothyroidism.

Hoʻopilikia ka hopena i nā hopena ʻaoʻao mai ka gastrointestinal tract me kahi koina o ka momona i ka meaʻai (ʻoi aku ma mua o 30% mau kaloli o kēlā me kēia lā). ʻO ka ke kau o ka lā i nā momona, nā pale a me nā ʻōleka e hoʻokaʻawale i waena o nā papa nui ʻekolu. No ka mea e hōʻemi ana ʻo orlistat i ka hoʻopili ʻana o kekahi mau momona a-momona o ka momona, pono nā mea maʻi e lawe i nā hoʻomākaukau multivitamin e loaʻa ana ka momona o ka momona o ka momona e hōʻoia i kā lākou ʻai kūpono. Eia kekahi, ʻo nā haʻawina o ka vitamina D a me ka beta-carotene ma nā maʻi hānai e haʻahaʻa e haʻahaʻa ma mua o nā poʻe i makemakeʻole i ka hina. Pono e lawe i ka Multivitamins i 2 mau hola ma mua a i ʻole 2 mau hola ma hope o ka lawe orlistat, no ka hoʻohālikelike ʻana, ma mua o ka hiamoe. I ka poʻe maʻi ʻaʻole i loaʻa i nā mea momona o prophylactic, i ka wā o ʻelua a i ʻole ka holo hou ʻana i ke kauka i ka makahiki mua a me ka lua o ka mālama ʻana me ka orlistat, ua hōʻemi ʻia ka nui o nā huaora i ka plasma. Ma muli o ka lawe ʻana o ka mauʻu K i ka wā e hoʻoemi ai i ka orlistat, i loko o nā mea maʻi e loaʻa ana i ka orlistat e pili ana i ke ʻano o ka hoʻohana ʻana i ka haka o ka warfarin, pono nā kiaʻi loiloi koko.

Loaʻa ka loaʻa ʻana o ka orlistat i nā wai he keu o ka nui o 120 mg 3 mau manawa i ka lā ʻaʻole e hāʻawi i kahi hopena hou.

Inā ʻaʻole hiki ke pale ʻia ka lawelawe ʻana i ka manawa like me ka cyclosporine, e pono ai ka hoʻomau ʻana o ka nānā ʻana i ka ʻike o ka cyclosporin i loko o ka plasma.

I kekahi mau mea maʻi, e kū'ē ana i ke kua o orlistat, hiki ke hoʻonui i ka ʻikepili o nā oxalates i loko o ka urine. E like me nā lāʻau'ē aʻe e hōʻemi i ka paona kino, i kekahi mau pūʻulu o nā maʻi (no ka laʻana, me ka anorexia nervosa a bulimia paha), aia ka hopena o ka hōʻino o ka orlistat.

Hiki i ka Orlistat induction o ka hoʻolilo ʻana i ke kaupaona ʻana me ka hoʻomehana i ka metabolic control o ka diabetes mellitus, pono e hoʻohaʻahaʻa i nā haʻahaʻa haʻahaʻa o nā waha hypoglycemic waha (derivatives sulfonylurea, metformin) a i ʻole insulin. Inā, ma hope o nā hebedoma o 12 o ka hopena me Xenalten ®, ʻo ka emi ʻana o ke kaumaha o ke kino he haʻahaʻa ma mua o 5% o ka kumu, pono e kūkā ke kauka e hoʻoholo ai e hoʻomau i ka mālama ʻana me orlistat.

ʻAʻole pono e hānai ʻia ka hoʻomehana ma mua o 2 mau makahiki.

ʻAʻole mālama ʻia ʻo Xenalten ® no ka hoʻohana ʻana ma ka hana pediatric.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a me nā mīkini neʻe i ka lawelawe. ʻAʻole pili i ka hiki ke hoʻokele i nā kaʻa a mālama i ka mīkini neʻe.

Nā ʻōkuhi no ka hoʻohana ʻana iā Orlistat, dosage

Lawe ʻia nā Kūpula ma ka wāʻai, e holoi ʻia me ka wai. Hoʻomaopopo nā kuhikuhi no ka hoʻohana ʻana iā Orlistat e lawe i ka lāʻau lapaʻau i nā manawa 3 i ka lā, i kēlā me kēia papa nui.

I ka hihia inā ʻaʻole ka meaʻai i ka momona, hiki iā ʻoe ke skip e lawe i ka lāʻau.

Nā ʻōlelo kikoʻī

No ka hōʻoia ʻana i ka lawa o ka ʻai ʻana o nā mea kanu a pau, ua pono ʻia e lawe i ka multivitamins (e lawe i ka liʻiliʻi ma 2 mau hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau a i ka wā hiamoe paha)

Pono e hoʻolako ʻia ka mea maʻi i kaʻai momona haʻahaʻa, ʻoiai ka hopena o nā hopena mai ka gastrointestinal tract e hoʻonui paha inā i lawe ʻia ʻo Orlistat i ka wā e ʻai ana i nā meaʻai me nā momona momona (ʻoi aku ka manaʻo, 2000 kcal / lā, ʻoi aku ka 30% i ke ʻano o nā kīpē, kahi e kū nei ma kahi o 67 g )

Nā hopena hopena

Hoʻomaopopo ka ʻōlelo aʻo i ka hiki ke hoʻomohala i nā hopena ʻaoʻao aʻe i ka wā i kuhikuhi ai iā Orlistat:

• Hoʻopili ʻia mai ke kahe,
• KeHulelehe
• ʻO ka hoʻokuʻu i nā wahi lepo me kahi nui o ka hoʻokuʻuʻana,
• Lūlū
• Steatorrhea
• Nā neʻe o ka naʻau i loko
• Pono makemake paha e hoʻohuli.
• Ka huhū ʻo Fecal.

Nā Hoʻohui

ʻO Orlistat i ʻōhumu ʻia ma kēia mau hihia:

• Cholestasis
• Malabsorption syndrome,
• Ke lalo o 18 mau makahiki
• ʻO ka hapai a me ka umauma,
• Ke hoʻohana pono nei me ka cyclosporine,
• Hypersensitivity o kekahi o nā lāʻau o ka lāʻau.

Kuhi me ke akahele:

• ʻO Neprolithiasis (ke alo o nā pōhaku kalima,)
• ʻO ka mōʻaukala o hyperoxaluria.

Ke keu

ʻO ka overdose, ma ke ʻano he kānāwai, e hōʻike ʻia e nā hopena ʻaoʻao mai ka gastrointestinal tract. Pono e nānā i ke kūlana o ka mea maʻi, maʻi therapy maʻa.

Nā kuhikuhi o Orlistat, ke kumukūʻai ma nā lāʻau lapaʻau

Inā pono, e pani i Orlistat, hiki ke hana ʻia me kēia analogue o ka mea hana - nā lāʻau lapaʻau.

Ke koho nei i nā mea kikoʻī, pono ia e hoʻomaopopo i nā ʻōlelo kuhikuhi no ka hoʻohana ʻana iā Orlistat, kumukūʻai a me nā loiloi e pili ʻole i nā lāʻau lapaʻau o ka hopena like. He mea nui ia e kamaʻilio pū me ke kauka kauka a ʻaʻole hoʻi e hana i kahi loli kūʻokoʻa kūʻokoʻa.

Kumukūʻai ma nā lāʻau lapaʻau Lūkia: Orlistat 60 mg 42 mau pōkole - mai 430 a i 550 mau rubles, 120 mg 42 mau pōkole - mai 1048 a 1200 rubles, e like me nā 793 mau lāʻau lapaʻau.

E hoʻomau i ka hiki ʻana o nā keiki, pale ʻia mai ka mālamalama a me ka ea, ma kahi pālahalaha ʻaʻole iʻoi aku ma mua o 25 ° C. ʻO 2 mau makahiki kahi ola.

ʻO nā kūlana o ka hāʻawi ʻana mai i nā lāʻau lapaʻau ma o ke kau ʻana.

4 ʻikepili no ka "Orlistat"

Lawe ʻia ka hapalua makahiki ma Orlistat. I kēia manawa, nalowale ka 28 kg. I ka wā mua, ua hōʻeha ʻia au e nā feces wai, a laila hoʻowahāwahā ʻia ka lāʻau lapaʻau maʻamau. I mea e hōʻemi uku ai i ke kaumaha, ʻoiaʻiʻo, ua hahai au i kahi papaʻai. I ka lā - ʻaʻole iʻoi aku ma mua o 1200 kcal.

Inā ʻaʻole ʻoe e ʻai i ka momona, a laila ʻaʻole pono ʻoe i kēia lāʻau. ʻAʻole ia e lawe i kou momona ponoʻī, e kāpae ʻo ia i nā mea i ʻai ʻia.

Ua nalowale au i ka momona, a me ka nui. ʻO ka mahina mua e pili ana ia 8kg ... a laila ma kahi o 5 ... ʻaʻole wau e waiho i loko o ka mika a ʻaʻole helu i nā lā. ʻO ka mea nui ka ʻae i ka hebedoma mua a lawe i ka mau huaora.

E hoʻokuʻu i ke ʻano a me ka ʻano

Hoʻomumu ʻia ka lāʻau lapaʻau i ke ʻano o nā kapapena: ka nui No. 1, ka gelatin paʻakikī, ke kino a me ka uhi polū, nā ʻāpana o nā kāʻei a kokoke i nā keʻokeʻo a keʻokeʻo paha (7 a 21 mau pcs. I nā kīwapa, i kahi pōpō kāleka 1, 2, 3, 4, 6 , 12 mau paʻi).

1 kiaʻi pahu:

• mea waiwai: orlistat - 120 mg,
• Nā kumuhana hou: sodium carboxymethyl starch (sodium starch glycolate), microcrystalline cellulose, povidone, talc, sodium lauryl sulfate,
• shell: titanium dioxide (E171), gelatin, dye blue patented.

Nā hōʻailona no ka hoʻohana ʻana

• therapy o ka momona, me ka hōʻoia no ka hoʻemi ʻana a me ka mālama ʻana i ke kaupaona o ke kino, i hui pū me ka meaʻai haʻahaʻa-calorie,
• ka hoʻemi ʻana o ka hoʻoweliweli o ka loaʻa hou ʻana o ke kaumaha kino ma hope o ka hōʻemi ʻana o kona hoʻoilo mua ʻana.

Hoʻomaopopo ʻia ka lāʻau lapaʻau no nā mea maʻi obese me kahi pūpū kiko o ke kino (BMI) ≥ 30 kg / m² a i nā mea maʻi me kahi BMI ≥ 28 kg / m² i mua o nā mea pili i ka hopena o ka obesity e like me ka arertial hypertension, dyslipidemia, a me mellitus maʻi diabetes.

Kuhi ʻia ka BMI e like me ka ʻano aʻe: M (M - ke kaumaha kino kino ma kg) / P 2 (P - kiʻekiʻe i m).

Nā Hoʻohui

• cholestasis
• mele malabsorption,
• makahiki i 18 makahiki
• hapai a me ka umauma,
• hana me ka cyclosporine,
• hypersensitivity o kekahi o nā lāʻau o ka lāʻau.

Relative (hoʻohana me ka akahele):

• nephrolithiasis (ke alo o nā pōhaku kalala ʻulaʻula)
• ka mōʻaukala o hyperoxaluria.

ʻŌpū a me ka lactation

I ka wā hāpai, lawe ʻia ʻo Orlistat, no ka mea ʻaʻohe data lapaʻau ʻoiaʻiʻo e hōʻoia ana i ka palekana o kona hoʻohana i nā wahine hāpai.

ʻAʻole i ʻike ʻia a ʻokuʻake ʻia ka lāʻau i loko o ka waiū kanaka, no laila ke contraindicated e lawe i ka lāʻau i ka wā lactation.

Hoʻohui nūhou

• phenytoin, amitriptyline, digoxin, sibutramine, fluoxetine, losartan, pravastatin, atorvastatin, contraceptives waha, glibenclamide, furosemide, nifedipine, ethanol, atenolol, captopril - ʻaʻohe lapaʻau koʻikoʻi me nā orlistist nānā
• ethanol, phenytoin (ma kahiʻu o 300 mg), digoxin (i hoʻohana ʻia ma ka pākahi hoʻokahi) - ʻaʻole i loli ka pharmacokinetics o kēia mau mea, ka hopena o ka ethanol i ka hoʻolaha ʻana i nā ʻōnaehana a me ka pharmacodynamics (excretion of fats with feces) o orlistat ʻaʻole i nānā.
• nifedipine (i ke ʻano o nā papa hoʻokuʻu i kākoʻo ʻia) - ʻaʻole i loli ka bioavailability o ka lāʻau.
• ʻO ka cyclosporin - e emi ana kona pae plasma, ʻaʻole pono ʻoe e lawe i kēia mau lāʻau lapaʻau i ka manawa like, inā pono, e pono ʻia ka hoʻohana pū ʻana o ka cyclosporin e hoʻohana i 2 mau hola ma mua a i ʻole ka lawe ʻana i ka orlistat (mālama mau i ke pae o ka cyclosporine i loko o ka plasma).
• acarbose - ʻaʻohe data i ka pilina o ka pharmacokinetic, ʻaʻole kōkua ʻia ka manawa like,
• amiodarone - me kēia hui, kahi hoʻemi i ka ʻike plasma o ka amiodarone ka mea i hoʻomaopopo ʻia, ka hui pū ʻana me ka orlistat e hiki wale nō ke kuhikuhi ʻia e ke kauka,
• anticoagulants kūlike (me ka warfarin) - hiki ke hoʻemi i ka pae o ka prothrombin a hoʻololi i ka waiwai o ka hōʻike o ka ʻōnaehana kaulike (INR) maʻamau, ma muli o kēia, e koi ʻia ka nānā ʻana o INR.
• beta-carotene - ua hoʻemi ʻia kona ʻano e 30%.
• pravastatin - hoʻonui i ka plasma o kēia mau mea (ma ka 30%) a me ka bioavailability, kahi e hiki ai ke hoʻonui i ka hopena lipid-lowing.
• ʻ Elelo E (i ke ʻano o tocopherol acetate) - ua hoʻemi ʻia kona ʻano e ka 60%.
• Nā lāʻau lapaʻau antidiabetic waha (sulfonylurea / metformin derivatives), insulin - pono paha e hōʻemi i ka pauʻana o kēia mau lāʻau ma muli o kahi hiki ke hoʻomaʻamaʻa i ka metabolism i loko o nā maʻi me ka maʻi mellitus.
• nā mea hoʻohālikelike waha - he mea hiki ke hoʻemi i kā lākou bioavailability (ma muli o ka hopena kūlohelohe o orlistat), e kū'ē ana i kahi kūlana o ke ʻano o ka maʻi o ka maʻi, ua manaʻo ʻia e hoʻohana i nā ʻano o ka mea o ka mea.

The analogs of Orlistat are: Listata Mini, Orsoten, Listata, Xenalten Slim, Orsoten Slim, Xenical, Xenalten Logo, Orliksen 120, Orliksen 60, Alli, Xenalten Light.

Nā Hōʻikeʻike o Orlistat

ʻO nā mea maʻi e lawe ana i ka lāʻau lapaʻau i ka hapanui o nā loiloi maikaʻi e pili ana iā Orlistat. Nui ka poʻe e ʻike ma hope o kahi papa o ka lāʻau ua hoʻokō lākou i ka lilo nui o ke kaupaona ʻana, ʻoiai ʻaʻohe mau hōʻike kūikawā o nā hopena maikaʻiʻole o ka lāʻau. ʻO ka lāʻau lapaʻau, e like me nā loiloi, e hana mālie akā kūleʻa, e ʻae iā ʻoe e emi i ka 10 kg o ke kaupaona ma kahi o ʻeono mahina. Manaʻo pū kekahi nā mea maʻi i ka wā mālama ʻana, e mālama pono i ka ʻai ʻai a koho i ka papahana kūpono no ka hakakā ʻana me ka ʻōpiopio ma lalo o ka mākaʻi ʻana o ka loea i ʻike.

Eia nō naʻe, aia kekahi o nā loiloi o nā maʻi hakiʻole, e hōʻike ana i ka hopena ʻole o ka lāʻau a i ʻole ka pau ʻole o ka hopena maikaʻi mai ka hopena. Aia kekahi nui hoʻi nā hoʻopiʻi e pili ana i ka hoʻomohala ʻana o nā hopena ʻokoʻa ʻole o ka orlistat, ma ke ʻano he kānāwai, i ka ʻōpū o ka ʻōpū, ka maʻi āpau, ke kīwaha ʻole ʻana me ka pale ʻole, a me ka nāwaliwali nui. Ua hōʻike ʻia ua hiki mai ka hopena o ka hopena ʻino loa i kekahi mau mea i hoʻokuʻu ai i ka lāʻau lapaʻau.