Dapril 20 mg: nā kauoha no ka hoʻohana ʻana

Loaʻa ʻo Dapril i ke ʻano o nā papa (10 mau ʻāpana i kēlā me kēia pōpoki blister, i loko o kahi pahu pahu: 5 mg a me 10 mg pākahi - 3 mau pākeke, 20 mg kēlā me kēia - 2 mau pākaʻi).

Pākaukau 1 papa:

• mea ikaika: lisinopril - 5 mg, 10 mg a 20 mg paha,
• nā mea kōkua: ka calcium hydrogen phosphate, mannitol, iron oxide (E172), magnesium stearate, gelatinized starch, starch.

Nā Hoʻohui

• ka moolelo o ke angioedema,
• hyperaldosteron's,
• pilikia hanalei,
• bilateral renal aren stenosis a i ʻole stereosis o ke keiki hoʻokahi me ka azotemia holomua,
• azotemia
• kūlana ma hope o ke hili ʻana,
• hyperkalemia
• nā stenosis o ka orifice aortic a me nā mea like me ka hemodenamic i hoʻohālikelike ʻia,
• nā makahiki o nā keiki
• II me III trimesters o ka wā hapai,
• hana waiū
• hypersensitivity i ka ACE inhibitors a me nā mea lapaʻau.

ʻLoe a me ke kākele

Lawe ʻia nā papa ʻelua.

Kūkulu ke kauka i ka hopena o ka lāʻau lapaʻau ʻokoʻa i luna o nā hōʻike maʻi a me nā pono o kēlā me kēia pono e hoʻokō i kahi hopena kūloko.

• hypertension arterial: maʻi mua - 10 mg 1 manawa i kēlā me kēia lā. ʻOi aku, koho ʻia ka pākēneka, ma ke ʻano he nui o ke koko (BP) o ka mea maʻi, ʻo ka mālama mālama mau ʻo 20 mg ka hoʻokahi i ka lā hoʻokahi, me ka loaʻa ʻole o kahi hopena therapeutic ma hope o nā lā 7 o ka lāʻau lapaʻau, hiki ke hoʻonui ʻia i 40 mg. ʻO ka nui loa ma ke ao ʻana he 80 mg,
• ka paʻa ʻole o ka puʻuwai: ʻo ke kumu mua loa he 2.5 mg i kēlā me kēia lā, ʻo ka mālama mālama ʻia he 5-20 mg i kēlā me kēia lā.

Ma kahi o ka hana renal impaired, ua hoʻomau ʻia ka make i kēlā me kēia lā i ka nānā ʻana i ka clearance creatinine (CC):

• ʻO QC ka nui ma mua o 30 ml / min: 10 mg,
• KK 10-30 ml / min: 5 mg,
• CC ma mua o 10 ml / min: 2.5 mg.

Nā hopena hopena

• mai ka pūnaehana cardiovascular: loaʻa - tachycardia, orthostatic hypotension,
• mai nā ʻōnaehana o ka naʻau: he naʻau o ka luhi, ka ʻeha, ka ʻeha, kekahi manawa - ka hilahila, ka hiki ʻana o ke ʻano,
• mai ka pūnaehana hemopoietic: agranulocytosis, neutropenia, hoʻohaʻahaʻa ka pae hemoglobin haʻahaʻa, kahi e hoʻokaʻawale ana i ka nui o nā ʻoka o ke koko,
• mai ka papa hana o ka hanu: auwā, ʻeha - ka maloʻo maloʻo, ka ʻōpū o ka ʻōpū, ke ʻehaʻī, i kekahi manawa - hoʻonui i ka hana o nā huina o nā pepeka, nui pae o ka bilirubin i loko o ka serum koko,
• nā maʻi kūlohelohe: jarang - ʻeha poloka, i kekahi manawa - ka edema Quincke,
• mai ka papa hanu: maloo,
• nā mea ʻē aʻe: kekahi manawa - hyperkalemia, pilikia ʻole.

Nā ʻōlelo kikoʻī

ʻO ka hoʻohana ʻana o ka ACE inhibitors hiki i ka hopena i ka hopena o ke ʻano o ka make maloʻo, e nalo ana ma hope o ka hōʻemi ʻana i ka lāʻau. Pono e noʻonoʻo pono i ka maʻi maʻamau o ka ʻōpū ma ka mea maʻi e lawe ana iā Dapril.

ʻO ke kumu o ka emi ʻana o ke kahe o ke koko, he haʻahaʻa ia o ka nui o ke kahe o ke kino e hoʻoulu ʻia ana e ka maʻi a maʻi ʻole paha, ka hoʻohana pinepine ʻana o ka diuretics, kahi hoʻohaʻahaʻa i ka paʻakai paʻakai, a i ʻole dialysis. No laila, ua ʻoi ʻia e hoʻomaka i ka mālama ʻana ma lalo o ka mākaʻikaʻi koʻikoʻi o kahi kauka a me ka makaʻala e hoʻonui i ka ʻōlelo o ka lāʻau.

I ka hoʻohana ʻana o ka hemodialysis i ka membranes me ka hoʻokūkū kiʻekiʻe, aia kahi kiʻekiʻe o ka hopena anaphylactic. No laila, no ka dialysis, pono ia e hoʻohana i nā membranes o kekahi ʻano ʻē aʻe a i ʻole ke hoʻololi i ka lāʻau lapaʻau me kekahi mea antihypertensive aila ʻē aʻe.

Hoʻohui nūhou

Me ka hoʻohana ʻana o Dapril:

• Diuretics pākaʻi paʻakai (triamteren, spironolactone, amiloride), nā huahana paʻakai e loaʻa ana i ka paʻakai pākela paʻakai - hoʻonui i ka pilikia o hyperkalemia, ʻoi aku me ka hana renal impaired,
• diuretics, antidepressants - kumu i hōʻemi ʻia ai ka nui o ke koko,
• ole-antiidal anti-inflammatory lāʻau lapaʻau - hōʻemi i ka hopena antihypertensive o ka lāʻau,
• mākaukau lithium - hoʻolohi i ka helu o kā lākou excretion mai ke kino,
• ethanol - hoʻonui i ka hopena o ka lāʻau.

Nā Dapril analogues: nā papa - Diroton, Lisinopril, Lisinopril-Teva, Lisinoton.

Ka hana lāʻau lapaʻau

ʻO Dapril kahi lāʻau lapaʻau antihypertensive mai ka pūʻulu o ka angiotensin-inhibiting enzyme (ACE) inhibitors me ka hopena lōʻihi. ʻO ka lisinopril mea kikoola he metabolite o enalapril (enalaprilat). ʻO Lisinopril, ʻae ʻana i ka ACE, e pale i ka hoʻokumu ʻana o ka angiotensin II mai nā angiotensin I. I ka hopena, ua pau ka hopena vasoconstrictor o ka angiotensin II. ka hoʻoneʻe ʻana o ka angiotensin III, he hopena maikaʻi inotropic a hoʻoneʻe, hoʻoneʻe i ka hoʻokuʻu ʻana ʻana o ka norepinephrine mai ka presynaptic vesicles o ka puʻuwai hoʻāla me ka hoʻoneʻe ʻana, ka hoʻokaʻawale ʻana o ka aldosterone i loko o ka wahi o ka glomerular o ka cortex adrenal a me ka hypokalemia e kumu ʻia ana me ka hoʻomakeʻa ʻana o ka sodium a me ka wai. Eia kekahi, aia kahi hōʻiliʻili o ka bradykinin a me nā prostaglandins e hōʻea i ka vasodilation. Ke alakaʻi nei kēia mau mea i ka hoʻohaʻahaʻa o ke koko, lohi a ʻoi aku ka liki ma mua o ke koho ʻana o ka captopril pōkole. No laila, ʻaʻole i hoʻonui ʻia ka piʻi o ka puʻuwai. Hoʻopau ʻo Lisinopril i ka pale o ka vascular a peripheral (OPSS) a ma hope o ka hoʻouka, ke alakaʻi nei i ka hoʻonui o ka hopena cardiac, ka hopena cardiac, a me ke kahe koko. Eia kekahi, hoʻonui ka nui o ka venous, preload, kaomi i ka atrium kūpono, nā māla pulmonary a me nā veins e emi iho, i.e. ma ka lime o ka pulmonary, ka hopena o ka hoʻōla o ka end-diastolic i ka ventricle hema ma ka ʻanuʻu, hoʻonui ʻia ka diuresis. Ke emi nei ka hana kānana i ka capilaries o ka glomerular a emi, hoʻemi ka proteinuria a hoʻoheheʻe ʻia ka hoʻomohala o ka glomerulosclerosis. Hōʻike ka hopena i nā hola 2 ma hope o ka lawe ʻana i ka lāʻau lapaʻau. Hoʻohui ka hopena kiʻekiʻe ma hope o nā hola 4-6 a kū i ka liʻiliʻi he 24 mau hola.

ʻLoe a me ke kākele

I ka loaʻa ʻana o ka maʻi hypertension, ʻo ka hoʻomaka mua o 5 mg 1 manawa i kēlā me kēia lā. ʻO ka papa mālama mālama a hiki i ka 20 mg hoʻokahi i kēlā me kēia lā. Me ka lāʻau lapaʻau o kēlā me kēia pule, hoʻonui ʻia ka nui o ka hopena i 20-40 mg i kēlā me kēia lā. Kahi ʻia ka koho Dose ma kēlā me kēia e pili ana i nā ʻōnaehana koko. ʻO ka dosis kiʻekiʻe loa he 80 mg i kēlā me kēia lā.

Ma kahi hikiʻole i ka puʻuwai pale, ke kumu mua o 2.5 mg i kēlā me kēia lā. ʻO ka papa mālama maʻi maʻamau ʻo 5 a 20 mg i kēlā me kēia lā.

I ka hihia o ka hana renal impaired, ua kau ke ʻano ma muli o ka cleance creatinine (QC). Me ka CC oi aku ma kahi o 30 ml / min, ʻo ka ʻōlelo i mālama ʻia he 10 mg / lā. Me CC mai 30 a 10 ml / min, ʻo ka mahele he 5 mg hoʻokahi i ka lā. Me ka CC ma lalo o 10 ml / min 2.5 mg.

Nā hōʻailona no ka hoʻohana ʻana

Hoʻohana ʻia ʻo Dapril e mālama ai:

• hypertension arterial (me ka renovascular) - hiki ke hoʻohana ʻia ka lāʻau lapaʻau me ka hui pū me nā lāʻau antihypertensive a i ʻole i ke ʻano o ka monotherapy,
• ka maʻi naʻau ʻole (no ka mālama ʻana i nā poʻe maʻi e lawe ana i nā diuretics a me / a i ʻole ka hoʻomākaukau ʻana i ka mea digitalis ma ke ʻano he hui hoʻohui).

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana

Loaʻa ʻo Dapril i ke ʻano o nā convex round pink tablets. Ua ʻae ʻia nā helu hoʻohālikelike a me nā male ʻole. Hoʻokomo ʻia nā papa i loko o nā pale i palama, a laila i loko o nā ʻeke o ka pepa.

Aia kēlā me kēia papa i ka lisinopril (mau mea hana maʻamau), a me nā mea waiwai - mannitol, E172, ka calcium hydrogen phosphate, nā kuka gelatinized, me ke kīwī, ka pākuʻi magnesium.

Hoʻopili pū me nā lāʻau ʻē aʻe

Hoʻohana ka hana like o Dapril me ka lako o ka paʻakai, nā paʻakai pālala, ka diuretics potassium-sparing (amiloride, triamteren, spironolactone) hoʻonui i ka hopena o ka hyperkalemia (ʻoi aku i nā mea maʻi me ka hana renal impaired), me ka NSAIDs, hiki ke hoʻonāukiuki i ka hopena o ka lisinopril, me nā antidepressants a me nā saluretics hypotension koʻikoʻi, me nā hoʻomākaukau lithium - lohi i ka lawe 'ana mai o ka lithium mai ke kino.

Hoʻonui ka hoʻohana ʻana i ka waiʻona i ka hopena hypotensive o ka mea ikaika.

I ka wā hāpai

Kuhi ka mea hana i ka hiki ʻole o ka hoʻohana lisinopril i ka wā o ka hōʻea. I ka wā ke hōʻoia ʻia ka ʻoiaʻiʻo o ka hapai, pono e hoʻokuʻu koke i ka lāʻau.

He mea nui e hoʻomanaʻo e pili ana ka mālama ʻana me ka ACE inhibitors i ka pōkole o ka 3 a me 2 ka hopena i ka hōʻeha i ka ʻōpū o nā pūpū (ʻo nā hoʻopiʻi hiki pū kekahi iā hyperkalemia, kahi make intrauterine, kahi mākaʻikaʻi i hōʻailona i ke koko, ke kīloʻi hypoplasia, hana ʻole i ka renal).

I ka manawa like, ʻaʻohe hōʻike hōʻike o ka hopena maikaʻi o ka lāʻau ma ka ʻōpona i ka trimester mua.

Inā ʻike ka mea hou a i ʻole pēpē i ka inhibitor ACE i loko o ka ʻōpū, pono ia e nānā pono i kona ʻano. Pono kēia no ka nānā ʻana i ka manawa hyperkalemia, oliguria, kahi hōʻailona i hōʻemi i ke koko.

Ua ʻike maopopo ʻia ka hiki i ka lisinopril ke komo i ka plasenta, akā ʻaʻohe mau ʻike i kona komo ʻana i loko o ka waiū umauma.

Me ke kīpē ʻana, ʻo ia ka mea e haʻalele iā ka pēpē ʻana no ka wā holoʻokoʻa me ka Dapril.

Nā kuleana a me nā kūlana e waiho ai

Hōʻike ka mea hana o Dapril i nā mea hoʻohana o ka pono e koho i kahi maloʻo malū a mālama ai i ka lāʻau lapaʻau.

I kēia hihia, ʻaʻole pono ka mahana o ka lewa i ka lumi ma mua o 25 mau kiʻekiʻe. ʻOiai wale nō e hoʻokō ʻia nā kūlana o luna, hiki ke mālama ʻia ka huahana no ke ola holoʻokoʻa o nā makahiki 4 mau makahiki.

ʻO ka awelika, hoʻokahi pā o Dapril i na kamaaina o Lusia Rukia 150 mau rubles.

Noho iho ka noho hoʻomanawanui i Ukraine, hiki ke kūʻai i kahi pūpū o ka lāʻau lapaʻau ma ka awelika no 40 hryvnia.

ʻO nā analogs Dapril e komo i nā lāʻau lapaʻau e like me Diroton, Diropress, Iramed, Zoniksem, Lizigamma, Lizakard, Lisinopril, Lisinoton, Lisinopril dihydrate, Lisinopril granulate, Rileys-Sanovel, Lizoril, Liziprex, Lizonlir, Lilonopril, Lilonopril, Lilonopril

Ma ka laulā, ʻo nā loiloi o nā mea hoʻohana pūnaewele e pili ana i ka lāʻau ʻo Dapril e kūpono maikaʻi.

Hoʻomaikaʻi maikaʻi nā maʻi a me nā kauka i ka lāʻau lapaʻau, e nānā ana i kona pono a me ka wikiwiki o ka hana.

Nū aku nā limahana olakino i kēia lā: ʻoiai ka nui o nā hopena ʻalike i hōʻike ʻia i loko o nā ʻōkuhi, he ʻokoʻa loa lākou (ʻo ka manawa o ka manawa i ʻike ʻia i nā hōʻike pono ʻole o kēlā me kēia ma waena o 0.01 a i 1%).

Hiki iā ʻoe ke heluhelu i ka loiloi o nā maʻi maoli e pili ana i ka lāʻau lapaʻau ma ka hope o ka ʻōlelo.

No laila, ʻo Dapril i hoʻonoho ai he lāʻau lapaʻau antihypertensive pono.

Ke noi ʻia nei ka lāʻau, no ka loaʻa ʻana, nā haʻahaʻa haʻahaʻa.

I mea e kūʻai ai i ka lāʻau lapaʻau ma kahi lāʻau lapaʻau, pono ʻoe e hōʻike i ke kauka ʻana i ke kauka.

Pehea e hoʻohana ai: dosis a me ke ʻano o ka mālama ʻana

I loko, me ka hypertension arterial - 5 mg hoʻokahi i ka lā. I ka hala ʻole o ka hopena, hoʻonui ʻia ka nui i kēlā me kēia mau lā 2-3 e 5 mg i ka awelika therapeutic awelika o 20-40 mg / lā (e hoʻonui ana i ka momona ma mua o 20 mg / lā maʻamau ʻaʻole alakaʻi i ka emi iki o ke kahe koko). ʻO ka palena kiʻekiʻe loa o kēlā me kēia lā he 80 mg.

Me ka HF - hoʻomaka me 2.5 mg hoʻokahi manawa, e ukali ʻia e ka hoʻonui hoʻomake wai o 2.5 mg ma hope o 3-5 lā.

I ka poʻe elemakule, ʻike pinepine ʻia ka hopena hypotensive lōʻihi i hōʻike ʻia, kahi i pili ʻia me ka hoʻēmi ʻana o ka helu lisinopril excretion (ua ʻōlelo ʻia e hoʻomaka i ka mālama ʻana me ka 2.5 mg / lā).

Ma ka hana ʻole o ka renal fail, hōʻalo ʻia ka cumulation me ka hoʻohaʻahaʻa ʻana i ka kānana o ka emi ma lalo o 50 ml / min (e hoʻemi ʻia ka nui o ka hōʻemi ma mua o 2 mau manawa, me CC ma lalo o 10 ml / min, pono ke hoʻemi ʻia ka nui ma ka 75%).

Me ka neʻe ʻana o ka hypertension arterial, hōʻike ʻia ka lōʻihi o ka mālama ʻana i ka mālama tamina i ka 10-15 mg / lā, me ka pohihihi ʻana o ka naʻau - ma ka 7.5-10 mg / lā.

Lapaʻau lāʻau

Hoʻopili ʻo Dapril i ka hoʻokumuʻana o ka hormone oligopeptide, kahi hopena vasoconstrictor. Aia nō hoʻi i ka emi ʻana o ke kū'ē o ka vascular peripheral, pre-and afterload i ka naʻau, hoʻomaʻamaʻa ʻole i ka hopena o ka puʻuwai a me ka nui o ke koko.

Eia kekahi, ʻo ka pale ʻana o nā moku ʻōhumu i emi a hoʻomaikaʻi ʻia ke kahe koko i loko o ke kino. I ka nui o nā manawa, ua hoʻemi ʻia ka emi ʻana o ke kaomi ma hope o ka lawe ʻana i ka lāʻau lapaʻau ma hope o nā hola 1-2 (ʻoi loa ma hope o nā hola 6-9).

Hoʻomaopopo ka hopena therapeutic kākoʻo ma hope o nā hebedoma 3-4 mai ka hoʻomaka ʻana o ka mālama ʻana. ʻAʻole kū i ka hopena kapa lāʻau.

I ka wā mālama, loaʻa ka hoʻonui i ka hiki ʻole i ka hana kino, ʻoiai i nā mea maʻi me ke koko koko kiʻekiʻe he nui ka emi ʻana o ke kahe o ka hoʻomohala ʻana me ka hoʻomohala ʻana i ka tachycardia reflex.

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Lapaʻau lāʻau

Hoʻopili ʻia ʻo Dapril e like me kahi o 25-50%. ʻAʻole loaʻa ka kiʻekiʻe o ke kaʻe ʻana o ka lāʻau lapaʻau e ka ʻai ʻana o ka meaʻai.

I loko o ke koko koko, hiki i ka lāʻau lapaʻau ke hōʻeha nui loa ma hope o nā hola 6-8.

ʻAʻohe kaupalena o ka lāʻau lapaʻau i nā protein a me ka metabolization, ʻaʻole i hoʻololi ʻia ka lāʻau lapaʻau e hoʻololi ʻia e nā keiki.

I ka hihia o ka hana renal lēʻaila, hoʻonui ka manawa o ka lāʻau lapaʻau e like me ke ʻano o ka hana nui.

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Hoʻohana ʻia ka dapril i ka wā hāpai

ʻO ka mea hana nui o Dapril ka lisinopril, ka mea i hiki ke komo i loko o ka pāʻai placental, no laila ʻo ka lawe ʻana i ka lāʻau lapaʻau ua contraindicated no nā wahine hāpai. ʻO ka lawe ʻana iā Dapril i ka wā hapai hiki ke hoʻopilikia i ka hoʻomohala ʻana o ka pūpū. ʻO ka lawe ʻana i ka lāʻau lapaʻau i ka mua a me ka lua o nā mea hoʻomaʻamaʻa hiki ke alakaʻi i ka make o ka hānau keiki, he hipoplasia skull, renal failed a me nā pilikia ʻē aʻe.

Ke keu

Ke lawe ʻia i ka nui o ka wai i ʻōlelo ʻia ʻia, hiki i ka hapril ke hōʻemi nui ʻana i ke kahe o ke koko, ke hele nui ʻana i ka wahaosa waha, hoʻomaikaʻi ʻana i ka nui o ka puʻuwai a me ka hanu, ka dizziness, ka haunaele o ka wai-electrolyte kaulike, hopohopo, irritability, mau hiamoe.

I kahi hihia o ka lāʻau lapaʻau nui, ʻānō ka lōʻihi o ka gastric a me ka hoʻokele ʻana o nā enterosorbents.

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ʻO ka pilina me nā lāʻau lapaʻau ʻē aʻe

Me ka mālama like ʻana o Dapril me nā lāʻau lapaʻau ʻē aʻe e hōʻemi i ke koko ((inā paha me ka diuretics), ʻike ʻia kahi hopena hypotensive.

ʻO nā lāʻau lapaʻo nonsteroidal me ka hopena anti-inflammatory (acetylsalicylic acid, ibuprofen, etc.), sodium chloride me Dapril e hōʻemi i ka hopena therapeutic o ka hopena.

ʻO ka mālama like ʻana o ka lāʻau me ka potassium a me ka lithium e alakaʻi i kahi kiʻekiʻe hoʻonui o kēia mau mea i ke koko.

Mea lapaʻau immunosuppressive, lāʻau antitumor, alopurinol, hormones steroid, procainamide i hui pū me Dapril alakaʻi i kahi emi o ka pae o leukocytes.

Hoʻonui ʻo Dapril i ka hōʻike ʻana mai i ka lāʻau ʻawaʻawa.

Hoʻopili i nā lāʻau Narkotic, painkillers i ka hopena therapeutic o Dapril.

Me ka hoʻomaʻemaʻe koko, hiki i nā kūlohelohe anaphylactic.

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