Nativa® (Nativa)
ʻAna Kalepa: Nativa
ʻOiai inoa ʻole inoa honua: Desmopressin
Inoa Kimia: 3-sulfanylpropanoyl-L-tyrosyl-L-phenylalanyl-L-lutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-D-arginylglycinamide cyclic 1-6 disulfide
Nā palapala ʻano: ʻO nā pōpō
Hoʻohālikelike papa pākaukau
ʻO ke ʻano waiwai 0.1 mg 0.2 mg
Desmopressin Acetate 0.1 mg 0.2 mg
i ka ʻōlelo a desmopressin 0.089 mg 0.178 mg
Nā mea kūʻai
Lactose Monohala 10 mg 10 mg
Crospovidone XL 5 mg 5 mg
ʻO ka lāʻau ʻo Magnesium 2 mg 2 mg
Ludipress a i ka 200 mg i ka 200 mg
e pili ana i nā ʻāpana:
Lactose Monohala 170.1 mg 170.0 mg
Crospovidone 6.4 mg 6.4 mg
Povidone 6.4 mg 6.4 mg
ʻO keʻano
Dosisage 0.1 mg: keʻokeʻo lapalapa papa keʻokeʻo me ka chamfer a me ka pilikia ma kekahi ʻaoʻao
Dosisage 0.2 mg: keʻokeʻo lapalapa papa keʻokeʻo me ka chamfer a me ka pilikia ma kekahi ʻaoʻao
Hoʻolaha hui: Hana ʻia ka maʻi mellitus
Manaʻo ATX: H01VA02
ʻO nā waiwai Pharmacological
Lapaʻau lāʻau
ʻO ka Desmopressin kahi analogue hoʻolālā o ka arginine-vasopressin hormone kūlohelohe, me kahi hopena antidiuretic i haʻi ʻia. Loaʻa ka Desmopressin ma muli o nā loli i ka ʻōnaehana o ka vasopressin - deamination o L-cysteine a me ka hoʻololi ʻana o 8-L-arginine no 8-D-arginine.
Hoʻonui ka Desmopressin i ka kahe o ka epithelium o nā tubule convoluted distalula o ka nephron i ka wai a hoʻonui i kona reabsorption. Hoʻololi ko nā loli i ka hoʻohui me ka hiki ke antidiuretic hoʻonui i ka hopena o ka desmopressin i ʻōlelo ʻia ʻole i nā ʻalika momona o nā kīʻaha koko a me nā kino kūloko i hoʻohālikelike ʻia me vasopressin, ka mea e alakaʻi ai i ka loaʻa ʻole o nā hopena spastic. ʻAʻole e like me vasopressin, hana hou aku a ʻaʻole ia e hoʻonui i ke kahe o ke koko (BP).
ʻO ka hoʻohana ʻana o desmopressin no ka maʻi maʻamau o ka maʻi i ka wai o ka urmidrine e hoʻoneʻe ai i ka nui o ka urine i hoʻopau ʻia a ma ka manawa like, he mahuahua o ka osmolarity o ka urine a me kahi hoʻēmi ʻana i ka osmolarity o ka plasma koko. Ke alakaʻi nei kēia i kahi emi o ka urination a me kahi laʻa o ka polyuria nocturnal.
ʻO ka hopena antidiuretic ka hopena i ka wā e lawe ai i ka waha ma 4 a 7 mau hola. Ka hopena antidiuretic i ka wā i lawe ʻia ma ka waha o 0.1 - 0.2 mg - a i 8 mau hola, i kahi wai o 0.4 mg - a hiki i 12 mau hola.
Lapaʻau lāʻau
Kapehu
Ke hoʻokele ʻia, ua hoʻokō ʻia ka pae plasma nui (Cmax) i loko o 0.9 hola. Hiki i ka ʻai ʻaina ke hōʻemi i ka pae o ke kaohi mai ka gastrointestinal tract (GIT) ma ka 40%.
Kahele
ʻO ka nui o ka hoʻoili (Vd) he 0.2 - 0.3 l / kg. Hoʻopuka ʻana i ka waha - 5%. ʻAʻole kū ʻo Desmopressin i ka pale koko-lolo.
Leʻaleʻa
Ke hoʻopio ʻia nei e nā ʻōpū. ʻO ka hapalua-ola (T1 / 2) i ka wā e lawe waha ʻia ai ʻo 1.5 i 2.5 mau hola.
Nā hōʻailona no ka hoʻohana ʻana
• diabetes indipidus o ka kumu waena
• ʻO nā Enuresis nocturnal primer i nā keiki he mau makahiki ma mua o 5 mau makahiki
• polyuria o Nocturnal i nā pākeke (ma ke ʻano he hōʻailona maʻi).
Nā maʻi hoʻohālikelike no ka hoʻohana
Inā loaʻa iā ʻoe kekahi o kēia mau maʻi, e noʻonoʻo e nīnau aku i kāu kauka ma mua o ka lawe ʻana i ka lāʻau lapaʻau.
• Nā hua maʻi ākea i ka desmopressin a i ʻole nā meaʻokoʻa o ka lāʻau lapaʻau
• Ka wahine a i ʻole ka psychogenic polydipsia
• Congestive naau ka hoʻokō 'ole a me nā rula e noi ana i ka hookohu o ka diuretic ai'
• Hyponatremia, me ka mōʻaukala o (ka uha o nā paʻakai sodium i loko o ke koko koko ma lalo o 135 mmol / l)
• He'ōwili maʻamau a me ka hōʻino nui ʻole (ka hana ʻana ma lalo o 50 ml / min)
• Ke keiki ma lalo o 4 mau makahiki (no ka mālama ʻana i ka maʻi diabetes diabetes) a me 5 mau makahiki (no ka mālama ʻana i ka enocis nocturnal primer)
• Syndrome o ka hana hemahema o ka hormone antidiuretic
• Ka nele o ka Lactase, ka lactose intolerance, glucose-galactose malabsorption.
Me ka mālama pono
hoʻohana i ka lāʻau lapaʻau no ka hiki ʻole o ka pale, blrosder fibrosis, no ka mau kuhi ʻana o ka pale o ka wai-electrolyte, i hiki ke piʻi ka nui o ka neʻe i ka hana intracranial, i ka wā hāpai.
Me ka makaʻala nui hoʻohana i ka lāʻau lapaʻau i nā mea maʻi maʻi (ma mua o 65 mau makahiki) ma muli o ka hiki ke kiʻekiʻe o nā hopena ʻokoʻa (ka hoʻomehana ʻana o ka maʻi, hyponatremia). I ka koho ʻana i ka lāʻau maʻi me Nativa, 3 mau lā ma hope o ka hoʻomaka ʻana o ka hoʻokele a me kēlā me kēia piʻi o ka nui o ka wai, e hoʻoholo ʻia ka ʻike ʻana o ka sodium i loko o ka lolo koko a pono e nānā ʻia nā kūlana o ka mea maʻi.
Hoʻohana i ka wā hāpai a i ka wā o ka umauma
Wahi a nā ʻike ʻike, i ka wā e hoʻohana ai ka desmopressin i nā wahine hāpai me ka maʻi diabetes insipidus, ʻaʻohe hopena o ka hopena o ka hāpai ʻana, ma ke kūlana olakino a ka wahine hāpai, ka ʻōpū a me ka pēpē.
Eia nō naʻe, pono ka hoʻomaʻamaʻa ʻia i ka makuahine a me ka hopena i hiki ke mālama ʻia i ka hoʻouka.
Ua hōʻike ʻia nā haʻawina ʻo ka nui o ka desmopressin e komo i ke kino o kahi keiki hou me ka umauma waiū o ka wahine e lawe ana i nā kiʻekiʻe o ka desmopressin ma mua o ka mea e hoʻopilikia ai i ka diuresis.
Dimence regimen, ʻano hana no ke noi ʻana, ka lōʻihi o ka mālama ʻana
I loko. Kahi ʻia ka hopena palekana o ka lāʻau i kēlā me kēia.
Pono ka lāʻau e hoʻokaʻawale i kekahi manawa ma hope o ka ʻai ʻana, ʻo ka mea ʻai e hiki ke hoʻopilikia i ka make o ka lāʻau a me kona pono.
Intipidus maʻi waena: ʻO ka papa hoʻomaka ʻia i hoʻomaka ʻia no nā keiki he 4 mau makahiki a ʻo nā mākua he 0.1 mg 1-3 mau manawa i ka lā. Ma hope aku, koho ʻia ke ʻano maʻi ma muli o ka pane ʻana i ka mālama ʻana. ʻO ka maʻamau, ʻo ka laʻana i kēlā me kēia lā mai 0.2 a 1.2 mg. No ka hapa nui o nā mea maʻi, ʻo ka hopena mālama mālama maikaʻi loa ʻo 0.1 - 0.2 mg 1-3 mau lā i ka lā.
ʻO nā ʻumeʻohana mua nocturnal: ʻO ka paipai hoʻomaka ʻana no nā keiki ma mua o 5 mau makahiki a ʻo nā mākua he 0.2 mg i ka pō. I ka nele o ka hopena, hiki ke hoʻonui ʻia i ka nui i ka 0.4 mg. ʻO ke aʻo ʻia no ka hoʻomau mau ʻana o 3 mau mahina. ʻO ka hoʻoholo e hoʻomau i ka mālama ʻia e hoʻoholo ʻia ma nā kumu o ka ʻepekema lapaʻau e ʻike ʻia ma hope o ka hoʻokuʻu ʻana o ka lāʻau lapaʻau i loko o hoʻokahi pule. Pono e nānā pono i ka hoʻokō ʻana i ka paʻa o ke kahe ʻana o ka wai ma ke ahiahi.
Nā polyuria makua i ka pō: ʻO 0.1 mg i hoʻomaka ʻia i ka pō. Inā ʻaʻohe mea ma loko o nā lā 7, e hoʻonui ʻia ka nui i ka 0.2 mg a ma hope iho i ka 0.4 mg me ka piʻi o ka maʻi me ka pane o ka ʻaʻole iʻoi aku ma mua o 1 mau manawa i ka pule. Hoʻomaopopo i ka pōʻino o ka noho kino o ke kahe i loko o ke kino. Inā ma hope o 4 hebedoma no ka mālama ʻana a me ka hoʻoponopono ʻana i ka wai i mālama ʻia ka hopena o ka lāʻau lapaʻau, e hoʻomau i ka hoʻohana ʻana i ka lāʻau.
Nā kiʻi 3D
Nā Palaki | 1 kōpō. |
mea ikaika: | |
desmopressin acetate | 0.1 mg |
0.2 mg | |
(ma nā ʻōlelo o ka desmopressin: 0.089 mg / 0.178 mg) | |
nā mea hoʻowalewale: lōpose lactose - 10/10 mg, crospovidone XL - 5/5 mg, magnesium stearate - 2/2 mg, ludipress - a hiki i ka 200 / a i ka 200 mg (monoholate lactose - 170.1 / 170 mg, crospovidone - 6.4 / 6 , 4 mg, povidone - 6.4 / 6.4 mg) |
ʻLoe a me ke kākele
I loko. Kahi ʻia ka hopena palekana o ka lāʻau i kēlā me kēia.
Pono ka lāʻau e hoʻokaʻawale i kekahi manawa ma hope o ka ʻai ʻana, ʻo ka mea ʻai e hiki ke hoʻopilikia i ka make o ka lāʻau a me kona pono.
Intipidus maʻi waena: ʻO ka papa hoʻomaka ʻia i hoʻomaka ʻia no nā keiki he 4 mau makahiki a ʻo nā mākua he 0.1 mg 1-3 mau manawa i ka lā. Ma hope aku, koho ʻia ke ʻano maʻi ma muli o ka pane ʻana i ka mālama ʻana. ʻO ka maʻamau, ʻo ka laʻana i kēlā me kēia lā mai 0.2 a 1.2 mg. No ka hapa nui o nā maʻi, ʻo ka hoʻomau mālama ʻia o ka mālama ʻana he 0.1-0.2 mg 1-3 mau manawa i ka lā.
ʻO nā ʻumeʻohana mua nocturnal: ʻO ka paipai hoʻomaka ʻana no nā keiki ma mua o 5 mau makahiki a ʻo nā mākua he 0.2 mg i ka pō. I ka nele o ka hopena, hiki ke hoʻonui ʻia i ka nui i ka 0.4 mg. ʻO ke aʻo ʻia no ka hoʻomau mau ʻana o 3 mau mahina. ʻO ka hoʻoholo e hoʻomau i ka mālama ʻia e hoʻoholo ʻia ma nā kumu o ka ʻepekema lapaʻau e ʻike ʻia ma hope o ka hoʻokuʻu ʻana o ka lāʻau lapaʻau no 1 pule. Pono e nānā pono i ka hoʻokō ʻana i ka paʻa o ke kahe ʻana o ka wai ma ke ahiahi.
Kālepa ʻo Nocturnal i nā pākeke: ʻO ka paena hoʻomaka ʻana he 0.1 mg i ka pō. Inā ʻaʻohe mea ma loko o nā lā 7, e hoʻonui ka nui i ka 0.2 mg a ma hope iho i ka 0.4 mg (ʻo ka nui o ka hoʻonui ʻana i ka pane aku ʻaʻole iʻoi aku ma mua o ka manawa o ka pule). Hoʻomaopopo i ka pōʻino o ka noho kino o ke kahe i loko o ke kino. Inā ma hope o 4 hebedoma no ka mālama ʻana a me ka hoʻoponopono ʻana i ka wai i mālama ʻia ka hopena o ka lāʻau lapaʻau, e hoʻomau i ka hoʻohana ʻana i ka lāʻau.
Mea hana
Nativa LLC, Lusia.
Pūʻōlelo loio: 143402, Rūsia, Moscow Wae, Krasnogorsk district, Krasnogorsk, st. ʻOkakopa 13.
Tel: 8 (495) 502-16-43, 8 (495) 644-00-59.
i-mail: [email protected], www.nativa.pro
Kāʻei o nā pūnaewele hana: 143422, Kahi rula, Krasnogorsk district, s. ʻO Petrovo-Dalnee, ke Lūkini Lūkini, 142279, ka Lāhui o Moscow, ka moku ʻo Serpukhov, Obolensk, ka hale kūkulu hale. 7–8 a i ʻole 143952, Kahiā Kūkoʻe, Balashikha, microdistrict. Dzerzhinsky, 40.
Nā Hoʻohui
- Hypersensitivity i ka desmopressin a i ʻole nā meaʻokoʻa o ka lāʻau lapaʻau,
- aea ʻole paha a psychdipsia i ʻole
- ka hewa puʻuwai a me nā kūlana e koi ai i ka lawelawe ʻana o diuretics,
- hyponatremia, me ka mōʻaukala o (konsentrate ka paʻakai pākia i loko o ke koko koko ma lalo o 135 mmol / l),
- nā mea maʻalahi i ka hāʻuleʻole o ka renal (ʻo ka hana ma hana ma lalo o 50 ml / min),
- nā keiki a hiki i ka 4 mau makahiki (no ka mālama ʻana i ka maʻi maʻi diabetes insipidus) a me 5 mau makahiki (no ka mālama ʻana i ke ʻano nocturnal prim)
- maʻi o ka hana kūpono ʻole i ka hormone antidiuretic,
- ka nele o ka Lactase, ka lactose intolerance, glucose-galactose malabsorption.
Hoʻohana ʻia nā ʻōiwi me ka mālama ʻole o ka pilikia o ka papaha, ka fibrosis bladder, i ʻole ka ʻohi ʻana i ka wai-electrolyte, hiki ke hoʻonui ʻia ke kahe o ka intracranial, i ka wā hāpai.
Pono e akahele ka nui o ka mālama ʻana i ka wā e hoʻohana ai i ka lāʻau lapaʻau i nā mea maʻi ma mua o nā makahiki (ma mua o 65 mau makahiki) ma muli o ka nui o ka hopena o nā hopena ʻokoʻa (hoʻokele waipuna, hyponatremia). I ka koho ʻana i ka lāʻau maʻi me Nativa, 3 mau lā ma hope o ka hoʻomaka ʻana o ka hoʻokele a me kēlā me kēia piʻi o ka nui o ka wai, e hoʻoholo ʻia ka ʻike ʻana o ka sodium i loko o ka lolo koko a pono e nānā ʻia nā kūlana o ka mea maʻi.
E hoʻokuʻu i ke ʻano a me ka ʻano
ʻO ka helu dosage o Nativa he 0.1 / 0.2 mg papa: ka pōʻai, pālahalaha, keʻokeʻo, me kahi chamfer a me ka hopena o ka ʻaoʻao (30 mau ʻāpana i nā haki wai, 1 pahu i loko o kahi pahu pahu).
Waihona 1 papa 0.1 / 0.2 mg:
- mea hana waiwai: desmopressin acetate - 0.1 / 0.2 mg, ma nā ʻano o desmopressin - 0.089 / 0.178 mg,
- ʻO nā mea kōkua: lactose monohydrate, crospovidone XL, magnesium stearate, ludipress (lactose monohydrate, crospovidone, povidone).
Pehea e hoʻohana ai: dosis a me ke ʻano o ka mālama ʻana
I loko, e koho lima ʻia ka nui o ka lāʻau.
Pono ka lāʻau e hoʻokaʻawale i kekahi manawa ma hope o ka ʻai ʻana, ʻo ka mea ʻai e hiki ke hoʻopilikia i ka make o ka lāʻau a me kona pono.
Intipidus diabetes waena: ʻo ke kaila hoʻomaka ʻia no nā keiki he 4 mau makahiki a ʻo nā mākua he 0.1 mg 1-3 mau manawa i ka lā. Ma hope aku, koho ʻia ke ʻano maʻi ma muli o ka pane ʻana i ka mālama ʻana. ʻO ka maʻamau, ʻo ka laʻana i kēlā me kēia lā mai 0.2 a 1.2 mg. No ka hapa nui o nā maʻi, ʻo ka hoʻomau mālama ʻia o ka mālama ʻana he 0.1-0.2 mg 1-3 mau manawa i ka lā.
ʻO nā Enuresis nocturnal primer: ʻo ka pona hoʻomaka ʻana no nā keiki ma luna o 5 mau makahiki a ʻo nā mākua he 0.2 mg i ka pō. I ka nele o ka hopena, hiki ke hoʻonui ʻia i ka nui i ka 0.4 mg. ʻO ke aʻo ʻia no ka hoʻomau mau ʻana o 3 mau mahina. ʻO ka hoʻoholo e hoʻomau i ka mālama ʻia e hoʻoholo ʻia ma nā kumu o ka ʻepekema lapaʻau e ʻike ʻia ma hope o ka hoʻokuʻu ʻana o ka lāʻau lapaʻau i loko o hoʻokahi pule. Pono e nānā pono i ka hoʻokō ʻana i ka paʻa o ke kahe ʻana o ka wai ma ke ahiahi.
Nā polyuria makua i ka pō: ʻO 0.1 mg i hoʻomaka ʻia i ka pō. Inā ʻaʻohe mea ma loko o nā lā 7, e hoʻonui ʻia ka nui i ka 0.2 mg a ma hope iho i ka 0.4 mg me ka piʻi o ka maʻi me ka pane o ka ʻaʻole iʻoi aku ma mua o 1 mau manawa i ka pule. Hoʻomaopopo i ka pōʻino o ka noho kino o ke kahe i loko o ke kino.
Inā ma hope o 4 hebedoma no ka mālama ʻana a me ka hoʻoponopono ʻana i ka wai i mālama ʻia ka hopena o ka lāʻau lapaʻau ʻana, e hoʻomau i ka hoʻohana ʻana i ka lāʻau.
Lapaʻau lāʻau
ʻO ka Desmopressin kahi kikoʻī i kālaila o ka arginine-vasopressin a ua loaʻa kahi hopena antidiuretic. Loaʻa ia ma ke aʻo ʻana o nā loli i ke ʻano o ka moliki vasopressin.
ʻO ka hana a Nativa ma muli o kona hiki ke hoʻonui i ka hiʻona o ka epithelium o nā wahi mamao o nā tubule convoluted o ka nephron i ka wai, e hoʻonui ana i kona reabsorption. ʻAʻohe hopena kūpono i ka wili ma muli o ka hopena o ka desmopressin i hoʻopihapiha ʻia i nā pulu manene o nā kīʻaha koko a me nā kino o loko i ka hoʻohālikelike ʻana me vasopressin. Pono ka lāʻau lapaʻau i ka manawa lōʻihi a ʻaʻole e hoʻonui i ke kahe koko.
I ka mālama ʻia ʻana o ka desmopressin me ka maʻi maʻi o ka maʻi indipidus o ke kumu waena, ua emi ka nui o ka urine excreted, hoʻonui ʻia kona osmolarity, a me ka osmolarity o ke koko plasma, e ʻae ana i ka emi ʻana o ka wā o ka urination a me kahi laʻa o ka polyuria pō. Kahi ka hopena o ka lāʻau i ka lōʻihi ma hope o 4-7 mau hola a kū i nā hola 8-12, e kau ana i ka hopena i lawe ʻia e Nativa.
Lapaʻau lāʻau
Loaʻa ka lōʻihi loa o ka desmopressin ma hope o 0.9 hola. ʻO ka ʻai ʻana e hōʻemi i ka loaʻaʻana o nā mea ma ka 40%. ʻO ka nui o ka hoʻoilina he 0.2-0.3 l / kg. ʻAʻole hiki i ka waiwai ke hoʻowai i ka pale-lolo. ʻO ka hoʻopauʻana hapa-hapalua ke ola i nā hola 1,5-2,5. Hoʻopau ʻia ʻo Desmopressin e nā keiki.
Nā ʻōkuhi no ka hoʻohana ʻana iā Nativa: ʻano a me ka helu ʻana
Lawe ʻia nā papa Nativa i kekahi manawa ma hope o kahi pāʻina. Koho ʻia ka hopena o ka lāʻau i kēlā me kēia hihia i kēlā me kēia.
- insipidus diabetes waena: ʻo ka ʻōlelo mua i ʻōlelo ʻia ʻo 0.1 mg, 1-3 mau manawa i ka lā, a laila hoʻonui ka nui ma muli o ka hopena o ka mea maʻi.
- enuresis nocturnal primer: ʻo ka pualikua mua ʻana ʻo 0.2-0.4 mg i ka wā hiamoe. ʻO ka lōʻihi o ka mālamaʻana e pili ana i 3 mau mahina. ʻO ka hoʻoholo no ka hiki ʻana o ke ʻano hana hou e hana ma ka kumu o ka ʻepekema i loaʻa i loko o 7 mau lā ma hope o ka hoʻokuʻu ʻana i ka lāʻau. I loko o ka wā mālama, ua hōʻike ʻia ʻo Nativa e hoʻopili i ka noho ʻana o ka hoʻopau ʻana i ke kao wai ma ke ahiahi,
- polyuria nocturnal i nā pākeke: ʻo ka manawa mua i ʻōlelo ʻia ʻo 0.1 mg i ka manawa hiamoe. I ka haʻalele ʻana o ka hopena ma hope o 7 lā o ka lawe ʻana i ka lāʻau lapaʻau, hiki nō ke hoʻonui i ka wai i ka 0.2, a ma hope iho he 0.4 mg / lā, me kahi manawa o ka pule. I ka hana ʻole ʻana o ka hopena therapeutic i loko o 4 mau pule o ka lawe ʻana iā Nativa, ʻoi aku ka nui o ke hoʻohana ʻana.
Nā hopena hopena
- ʻūnaalela kikowaena: ʻeha, hoʻohālikelike, kope,
- hana kaoʻi: ʻāha, luaʻi, maloʻo ka ʻōpū.
- cardiovascular system: helehelena transachal
- nā mea i ʻike: conjunctivitis,
Eia kekahi, ʻo ka hōʻea o ka edema peripheral, me ka hoʻonui hoʻi i ka paona kino.
ʻO ka lawe ʻana iā Nativa me ka ʻole o ka paʻa i loko o ka intake kahe e hiki ai ke hoʻomau i ka mālama ʻana i ka wai ma ke kino a me ka hyponatremia.
Ke keu
ʻO ka overdose o Nativa hiki ke alakaʻi i ka mālama o ka wai a me ka hyponatremia me ka ʻaina o nā kīwai sodium i loko o ke koko koko ma lalo o 135 mmol / L.
Hoʻolaha i nā hana lapaʻau: kāpae koke i ka lawe ʻana i ka lāʻau, hoʻopau i ka hoʻoponopono o ka waiwai o ka inu ʻana, inā pono, e hoʻopili i ka 0.9% a i ʻole ka hopena o ka sodium chloride hypertonic. Ma kahi o nā hōʻailona o ka mālama paʻa ʻana i ka wai o ka maʻi (hōʻeha ʻana, hoʻoluhi ka ʻike ʻana), ua kauoha ʻia ka furosemide.
Nā ʻōlelo kikoʻī
Pono e kaupalena i ka hoʻoluhi wai ma ka hola 1 i mua o a no 8 mau hola ma hope o ka lawe ʻana iā Nativa, e pale i ka hopena o kona mau hopena.
Wahi a nā ʻōlelo kuhikuhi, ua contraindicated ʻo Nativa i nā poʻe maʻi ma ke ʻano e pili ana i ka hoʻomoʻe ʻana i ka wai me nā pilikia electrolyte.
I mea e pale ai i ka hoʻomohala ʻana o ka hyponatremia, ua makemake ʻia e hoʻomalu i ka lime o ka sodium i ka plasma koko.
I ka poʻe maʻi me ka maʻi wā o ka urinary incontinence, nocturia, dysuria, maʻi urinary tract, polydipsia, decompensated diabetes mellitus, a inā pū kekahi he pōpō a i ʻole prostate paha, ua manaʻo ʻia e mālama a loiloi i kēia mau maʻi ma mua o ka lawe ʻana iā Nativa.
Hoʻomaopopo ʻia e pale i ka lawe ʻana iā Nativa ma kahi o nā maʻi o nā ʻōnaehana, gastroenteritis a me ka maʻi pākī.
ʻŌpū a me ka lactation
ʻAʻohe ʻikepili i ka hopena maikaʻi o ka desmopressin i ka wā hāpai, ke ʻano o ka ʻōpū, ka pēpē, a me ka makuahine, akā ma mua o ke hoʻohana ʻana iā Nativa, pono e kaupaona ʻia ka hopena o ka waiwai.
ʻO ka nui o ka lāʻau i hoʻopuka ʻia i ka waiū makuahine i ka wā e lawe ai iā Nativa i nā dosis nui he mea liʻiliʻi ʻole e pili i ka diuresis o ke pēpē.
Hoʻohui nūhou
- nā lāʻau lapaʻau hypertensive: hiki i ka hoʻonuiʻana i ka hoʻonui i kā lākou hopena,
- buformin, tetracycline, norepinephrine, hoʻomākaukau o ka lithium: hoʻemi i ka hopena antidiuretic o desmopressin,
- Non-steroidal anti-inflammatory drugs (NSAIDs): hoʻonui i ka hopena o ka hopena ʻaoʻao;
- indomethacin: hoʻonui i ka hopena o ka desmopressin me ka hoʻonui ʻana i kona lōʻihi o ka hana,
- antidepresants tricyclic, selotonin reuptake inhibitors, narcotic analgesics, carbamazepine, chlorpromazine, lamotrigine, NSAIDs: hiki ke hoʻonui i ka hopena antidiuretic o Nativa, e hoʻonui ai i ka nui o ka hoʻopaʻa ʻana o ka waihā a me ka hyponatremia.
- loperamide a, inā paha, nā lāʻau lapaʻau e hoʻolōʻihi i ka peristalsis: hiki ke alakaʻi i kahi piʻi ʻekolu ʻekolu i ka paʻa ʻana o ka desmopressin i ka plasma, e hoʻonui nui ana i ka maʻi o ka hoʻomau me ka hyponatremia,
- dimethicone: Hiki ke hōʻemi ʻia ka desmopressin pagsiki.
ʻO nā inoa o Nativa nā Vasomirin, Desmopressin, Minirin, Nourem, Presineks.
ʻO ke kumu kūʻai o Nativa i nā lāʻau lapaʻau
ʻO ka uku kuhi o Nativa he 1330 r no ka pākeke i loaʻa iā 30 mau papa o 0.1 mg.
Hoʻonaʻauao: Rostov State Medical University, kūikawā "General Medicine".
Hōʻike nui ʻia ka ʻike e pili ana i ka lāʻau lapaʻau, i hoʻolako ʻia no ka hana ʻike a ʻaʻole hoʻololi i nā ʻōlelo aʻoaʻo. Hoʻopilikia ka lāʻau-pono iā ia ke olakino!
Wahi a nā kānaka ʻepekema he nui loa ka hoʻohana ʻana i nā mea ʻona no ka poʻe.
Me ka kipa pinepine ʻana i ka moena maka, hiki i ka manawa o ka loaʻa ʻana o ka maʻi maʻi kino e hoʻonui ʻia e 60%.
Ma UK, aia kekahi kānāwai e like me ka mea e hiki ai i ka mea maʻi ke hōʻole e hana i ka hana ma ka mea maʻi inā ulaula a i ke kaupaona ʻana. Pono ke kanaka e haʻalele i nā hana ʻino, a laila, ʻaʻole paha, ʻaʻole pono ia e kāpili ʻia.
ʻOi aku ka ikaika o nā iwi kanaka ʻehā ma mua o ka konihi.
ʻO James Harrison kahi kanaka 74 o kāna makahiki o Australia, ua lilo ia i mea honi koko ma kahi o 1,000 mau manawa. Loaʻa iā ia kekahi ʻano koko nui, nā antibodies o nā mea kōkua i nā pēpē hou me ke anemia koʻikoʻi. No laila, ua mālama ʻo Australia i kahi miliona miliona keiki.
Ke "holo nei ke koko kanaka" ma o nā moku ma lalo o ka pīhoihoi nui, a inā i uhai ʻia kona kūpaʻa, hiki iā ia ke pana a 10 mau mika.
ʻO ka mea ma mua, ʻo ia ka hana ʻana i ke kino me ka oxygen. Akā, ua kolohe ʻole kēia ʻike. Ua hōʻoia nā ʻepekemaʻepekema i ka yawning, hoʻokaʻawale kahi kanaka i ka lolo a hoʻomaikaʻi i ka hana ʻana.
Inā ʻoe e minoʻaka a ʻelua wale i ka lā, hiki iā ʻoe ke hoʻohaʻahaʻa i ke koko a hōʻemi i ka hopena o nā hōʻeha o ka naʻau a me nā kī.
I ka wā hake, hoʻopau kā mākou kino i ka hana. Holo ka naʻau.
Wahi a WHO noiʻi, ʻo ke kūkākūkā o kēlā me kēia hola i kēlā me kēia hola kelepona i hoʻonui ʻia i ka ulu ʻana o ka ulu ʻana o ka lolo ma o 40%.
ʻO ka paona o ka lolo o ke kanaka e pili ana i 2% o ka nui o ke kaupaona kino, akā e hoʻopau iā ia ma kahi o 20% o ka oxygen e komo ana i ke koko. ʻO kēia mea hana i nā ʻuhane o ke kanaka i maʻalahi e hōʻino ʻia e ka ʻakee ʻole o ka oxygen.
Hiki i kā mākou mau lolo ke hoʻomaʻemaʻe i ʻekolu liters o ke koko i hoʻokahi mau minuke.
ʻO ka nui ka mea ikaika loa o ko mākou kino. ʻO 1.5 ka paona nui ko 1.5 kg.
Ua hana ka poʻe ʻepekemaʻAmelika i nā hoʻokolohua ma nā kaole ka hopena a paʻa ka wai wai melemele i ka hoʻomohala ʻana i ka atherosclerosis o nā kīʻaha koko. Hoʻokahi kekahi pūʻulu o nā kiʻi i ka wai anuanu, a ʻo ka lua o ka wai wai kinawai. ʻO ka hopena, ua kaʻawale nā ipu o ka hui lua i nā kolika poli o ka kolamu.
Meliila a keu ka hānau ʻana, ola a make a puna i kā mākou puna. Hiki ke ʻike ʻia lākou ma ka hoʻonui ʻana nui, akā inā i hui pū ʻia, e kūpono lākou i loko o kahi kīʻaha kīkaha maʻamau.
ʻO ka nalu mua o ka pua e hele mai ana i kahi hopena, akā e hoʻohuli ʻia nā lāʻau pua i nā mauʻu mai ka hoʻomaka ʻana o Iune, ʻo ia ka mea e hoʻopilikia ai i nā maʻi āpau.
Ka hana lāʻau lapaʻau
ʻO ka pakanā ikaika o Nativa he desmopressin, kahi hōʻailona hoʻohui o ke ʻano kūlohelohe o ka hormon arginine-vasopressin, me kahi hopena antidiuretic i haʻi ʻia. Hoʻonui ka Desmopressin i ka kahe o ka epithelium o nā tubule convoluted distalula o ka nephron i ka wai a hoʻonui i kona reabsorption. Hoʻololi ko nā loli i ka hoʻohui me ka hiki ke antidiuretic hoʻonui i ka hopena o ka desmopressin i ʻōlelo ʻia ʻole i nā ʻalika momona o nā kīʻaha koko a me nā kino kūloko i hoʻohālikelike ʻia me vasopressin, ka mea e alakaʻi ai i ka loaʻa ʻole o nā hopena spastic. ʻAʻole e like me vasopressin, hana hou aku a ʻaʻole ia e hoʻonui i ke kahe o ke koko (BP).
ʻO ka hoʻohana ʻana o desmopressin no ka maʻi maʻamau o ka maʻi i ka wai o ka urmidrine e hoʻoneʻe ai i ka nui o ka urine i hoʻopau ʻia a ma ka manawa like, he mahuahua o ka osmolarity o ka urine a me kahi hoʻēmi ʻana i ka osmolarity o ka plasma koko. Ke alakaʻi nei kēia i kahi emi o ka urination a me kahi laʻa o ka polyuria nocturnal.
ʻO ka hopena antidiuretic loa i ka wā i lawe ʻia ai i ka waha ma 4-7 mau hola. ʻO ka hopena antidiuretic i ka wā i lawe ʻia ma ka waha o 0.1-0.2 mg e mau ana i 8 mau hola, ma ke ʻano he 0.4 mg - a hiki i 12 mau hola.