Nā papa hana ʻulaʻī mai ka melemele a me ka melemele me kahi hāmi ʻōmaʻomaʻo, oval, ka liʻiliʻi o ka biconvex, me ka loaʻa ʻana o ka ʻaoʻao ma ke ʻano, ʻo ke ʻano o ka papa ma ke ʻāpana ʻāpana ke kumu o ka papa keʻokeʻo.

Nā mea hoʻihoʻi: nā kīʻaha pregelatinized - 34.92 mg, cellulose microcrystalline - 87.7 mg, lōpose lactose - 63.13 mg, magnesium stearate - 1.75 mg.

ʻO ka hoʻonohonoho ʻana o ka ʻāpana film: hypromellose - 5 mg, macrogol 4000 - 0,5 mg, dye quinoline yellow (E104) - 0.11 mg, titanium dioxide (E171) - 1.39 mg, talc - 0,5 mg.

10 kamepiula - blisters (3) - nā ʻeke pepa.
10 kamepiula - nā kāmele (6) - nā kīwaha o ke kāleka.
10 kamepiula - nā kāmele (9) - nā kīʻaha o ke kāleka.

Ka hana lāʻau lapaʻau

Hoʻohui hui antihypertensive ʻO Losartan a me hydrochlorothiazide he hopena hoʻohui antihypertensive, e hoʻohaʻahaʻa ana i ke kahe koko i kahi nui aʻe ma mua o nā hui āpau.

Losartan he antagonist koho a nā ʻāpana ʻāpana angiotensin II (type AT 1) no ka hoʻokō waha. In vivo and in vitro, losartan and its pharmacologically active metabolite E-3174 block all the physiologically significant effects of angiotensin II on AT 1 receptors, atena o ke ala o kāna synthesis: alakaʻi ia i ka hoʻonui o ka hana renin koko a me ka hoʻohaʻahaʻa ʻana i ka paʻa o ka ald testosterone i loko o ke koko koko. Hoʻololi ʻo Losartan i ka hana ʻana i nā mea hoʻoponopono o ka AT 2 e ka hoʻonui ʻana o ka neʻe o ka angiotensin II. ʻAʻole ia i pale i ka hana a kininase II, kahi enme e komo i ka metabolism o ka bradykinin. He hōʻemi ia i OPSS, kaomi i ke kaomi pulmonary, e hōʻemi ana i ka myocardial afterload, loaʻa kahi hopena diuretic. Kūleʻa ʻia me ka hoʻomohala ʻana o ka hypertrophy myocardial, hoʻonui i ka hoʻolahalaha ʻana i nā maʻi me nā maʻi ʻoi aku ka maʻi paʻakikī (CHF). ʻO ka lawe ʻana i ka losartan 1 ka manawa / lā alakaʻi i kahi nui statistically nui i ka systolic a me ka diastolic blood pressure.

Mālama ʻo Losartan i ke kahe o ke koko i ka wā o ka lā, ʻoiai ka hopena antihypertensive e pili ana i ka ʻenehana circadian kūlohelohe. ʻO ka emi ʻana o ke koko i ka hopena o ka hopena o ka lāʻau lapaʻau ma kahi o 70-80% o ka hopena kiʻekiʻe loa o losartan, 5-6 mau hola ma hope o ka nānā ʻana. ʻAʻohe mea pale maʻi.

ʻAʻohe o Losartan e hopena koʻikoʻi i ka puʻuwai pu, i ka hopena uricosuric a me ka transient.

ʻO ka hole waiwai- kahi diuretic thiazide, ka hopena diuretic e pili ana i ka hana hewa ʻana i ka reabsorption o ka sodium, chlorine, potassium, magnesium, ions wai ma ka distal nephron, e kāpae i nā mea i pau i nā kaluna o nā calcium, a me nā wai uric. Loaʻa ia he hopena antihypertensive, ka hana a ka mea e hoʻomohala ai ma muli o ka hoʻonuiʻia o ka arterioles. ʻAʻohe hopena i kahi kahe koko maʻamau. Hoʻolaha ka hopena diuretic ma hope o nā hola 1-2, hiki i ka lōʻihi ma hope o 4 mau hola a lōʻihi i nā hola 6-12. ʻO ka hopena antihypertensive ka hopena ma hope o nā lā 3-4, akā hiki paha i nā 3-4 mau pule e hoʻokō ai i ka hopena therapeutic hopena.

Ma muli o ka hopena diuretic, hoʻonui ka hydrochlorothiazide i ka hana o ka plasma renin, hoʻoulu i ka mea huna o ka ald testosterone, hoʻonui i ka ʻike o ka angiotensin II a hoʻoneʻe i ke kāohi o ka paʻakai i ka plasma koko. ʻO ka loaʻa ʻana o nā poloka losartan e pili ana i ka hopena o ke kino o ka angiotensin II a, ma muli o ke kaohi ʻana o nā hopena o ka aldosterone, hiki ke kōkua i ka hōʻemi o ka potoma e pili ana i ka lawe ʻana i kahi diuretic. Hiki i ka Hydrochlorothiazide ke hoʻonui iki i ka hoʻoliʻiliʻi o ka waikika uric i loko o ke koko, ka hui pū ʻana o losartan a me hydrochlorothiazide e kōkua i ka hōʻemi o ka nui o ka hyperuricemia i loaʻa e kahi diuretic.

Lapaʻau lāʻau

ʻO nā pharmacokinetics o losartan a me hydrochlorothiazide me ka hoʻohana like ʻole i ʻokoʻa ʻole i ko lākou hoʻohana ʻana me ka monotherapy.

Ma hope o ka lawelawe waha, ua maikaʻi maikaʻi ka losartan mai ka digestive tract. Hana ia i ka metabolism koʻikoʻi i ka "papa mua" ma o ka ate, e hana ana i ka carboxylated metabolite carboxylated metabolite (E-3174) a me nā metabolite ikaika ʻole. ʻO ka bioavailability e pili ana i ka 33%. ʻO ka awelika C max o losartan a me kāna metabolite hōʻino ua loaʻa ma hope o 1 hola a ma hope o nā hola 3-4, kēlā me kēia. ʻO Losartan a me kāna hana metabolite paʻa e hoʻopaʻa i nā protein plasma (ʻoi loa c) ma mua o 99%. ʻO V d o losartan he 34 lita. E komo pū ana i loko o ka BBB.

Hoʻololi ʻia ka Losartan e hana i kahi metabolite ikaika (E-3174) (14%) a i ʻole hana ʻole, me ka lua o nā metabolites nui i hoʻokumu ʻia e ka hydroxylation o nā pūʻulu butyl o ke kaulahao a me kahi metabolite liʻiliʻi liʻiliʻi, N-2-tetrazolglucuronide. ʻO ka wehe i ka plasma o ka losartan a me kāna metabolite hoʻoikaika e like me 10 ml / sec (600 ml / min) a me 0.83 ml / sec (50 ml / min), kēlā me ia. ʻO ka hoʻomaʻemaʻe ʻana i ka renal o ka losartan a me kāna metabolite hoʻoikaika e pili ana i ka 1.23 ml / sec (74 ml / min) a me 0.43 ml / sec (26 ml / min). T 1/2 o ka losartan a me ka metabolite ikaika e 2 mau hola a he 6-9 hola, ia wa. Hoʻopili ʻia ia me ka bile ma o ka ʻōpū - 58%, keiki - 35%. ʻAʻole hoʻoiho.

Ke lawe waha ʻia ma nā inika a hiki i ka 200 mg, losartan a me kāna hana metabolite i ka lineac pharmacokinetics.

Ma hope o ka lawelawe waha, ʻo ka hoʻokomo ʻana o ka hydrochlorothiazide, ʻo 60-80%. Loaʻa ka C max i loko o ke kaila koko he 1-5 hola ma hope o ka nānā ʻana. Hoʻohālikelike i nā protein plasma koko - 64%. Penetrates ma o ka paepae placental. Hoʻokahi ʻia ma ka umauma wai. ʻAʻole i hoʻohālikelike ʻia ka Hydrochlorothiazide a ua lawe wikiwiki ʻia e nā keiki. ʻO T 1/2 mau hola 5-15. Ma ka hapa iki o 61% o ka nui i lawe ʻia ma ka waha he 24 nane i hoʻololi ʻia i loko o 24 mau hola.

Hypertension arterial (i nā poʻe maʻi e hōʻike ʻia ana i ke ʻano hui lāʻau), hōʻemi ʻia ka hopena o ka morbidity cardiovascular a me ka make ma ka poʻe maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular.

Nā Hoʻohui

Anuria, pilikia hōʻeha o ka renal (CC 20 kg a me 50 kg, ma mua he 50 mg 1 mau manawa i kēlā me kēia lā. I nā hanana kūikawā, hiki ke hoʻonui ʻia i kēia ke kau a kiʻekiʻe -100 mg 1 mau manawa i kēlā me kēia lā. a i ʻole 100 mg) i kēlā lā i kēia lā i keiki ʻaʻole i aʻo ʻia.Losartan ʻaʻole ʻia i hoʻohana ʻia no ka hoʻohana ʻana i nā keiki ma lalo o 6 mau makahiki o ka makahiki, ʻoiai nā ʻikepili i ka hoʻohana ʻana o ka lāʻau i loko o kēia pūʻulu o nā maʻi i lawa ʻole.
ʻAʻole kuhikuhi ʻia ka lāʻau lapaʻau no nā keiki me kahi helu filtration glomerular o 5.5 mmol / l) i nānā ʻia ma ka 1.5% o nā mea maʻi me ka hypertension.
ʻO nā mea maʻi me ka hypertrophy ventric hema

Mai ka ʻaoʻao o ke kino o ka hoʻolohe a me ke kaulike: pinepine - vertigo.

Hoʻopau ʻole nā ​​puʻuwai naʻau
Mai ka ʻōnaehana o ka pīpī: pinepine - nā dizz, headache, jarang - paresthesia.
Mai ka ʻaoʻao o ka naʻau: jarang - syncope, atrial fibrillation, stroke.
Mai ka pūnaehana vascular: pinepine - hypotension arterial, komo orthostatic hypotension.
ʻO ka hanu, thoracic a me nā mediastinal disorders: pinepine - dyspnea.
Mai ka hānaʻi ʻana o ka pānaʻi ʻana: pinepine - ka maʻi palau, ke kala, a luaʻi.
Ma ka ʻāpana o ka ʻili a me nā kiko o ka subcutaneous: pinepine - urticaria, itching, rash.
ʻO ka maʻi maʻamau a me nā maʻi e pili ana i ke ʻano o ka hoʻohana ʻana i ka lāʻau: pinepine - ka asthenia / nāwaliwali.
Nā hōʻailona hana o ka Laboratory: pinepine - hoʻonui i nā pae o ka urea, Mea hana i ka serum a me ka potassium i ka serum.

AH a me ke ʻano type type II mellitus i hele pū ʻia e nā maʻi maʻi
Mai ka pūnaehana nūhou: pinepine - dizziness.
Mai ka ʻōnaehana vascular: pinepine - hypotension arterial.
ʻO ka maʻi maʻamau a me nā maʻi e pili ana i ke ʻano o ka hoʻohana ʻana i ka lāʻau lapaʻau: pinepine - asthenia / nāwaliwali.
Nā hōʻailona hōʻailona Laboratory: pinepine - hypoglycemia, hyperkalemia.
ʻO kēia mau hopena hoʻonā e loaʻa pinepine ana i nā poʻe maʻi e lawe ana i ka losartan ma mua o nā mea maʻi i ka hui plasebo.
Mai ke koko a me ka papahana lymphatic: unknown - anemia.
Mai ka ʻaoʻao o ka naʻau: ʻike ʻole - syncope, palpitation.
Mai ka pūnaehana vascular: ʻike ʻole - hypotension arthial arterial.
Mai ka hāwele ʻana: ʻike ʻole - ʻeha.
Mai ka ʻōnaehana musculoskeletal a me nā hono hoʻohui: ʻaʻole maopopo - ʻeha hoʻi.
Mai nā pūpū a me nā maʻi urinary: ʻike ʻole - maʻi pāpaʻi urinary.
ʻO ke ʻano maʻamau a me nā maʻi e pili ai me ke ʻano o ka hoʻohana ʻana i ka lāʻau: ʻike ʻole - e like me nā hōʻailona like ʻole.
Nā hōʻailona hōʻailona: nā maʻi me ka maʻi diabetes mellitus type 2 a me nephropathy i mālama ʻia me nā losartan tablet i loaʻa ka hyperkalemia> 5.5 mEq / L i hoʻohālikelike ʻia me nā mea maʻi ma ka hui plasebo.

ʻO ka nānā ʻana ʻana-kūʻai ʻana i ka kūʻai
I ka nānā ʻana o ka post-marketing, ua hōʻike ʻia nā hopena hope aʻe:
Mai ke koko a me ka hoʻonohonoho lymphatic: ʻike ʻole - anemia, thrombocytopenia.
Mai ka ʻaoʻao o ka io o ke poʻo a me ka maze: ʻaʻole maopopo - kani i ka pepeiao.
Ma ka ʻāpana o ka ʻōnaehana pale: aniani - kūlike hypersensitivity (anaphylactic reaction, angioedema, me ka swelling o ka larynx a me ka glottis, ka mea e alakaʻi ai i ka neʻe ʻana o nā alaloa a me / a me ka huki ʻana o ka maka, nā lehelehe, pharynx a / a i ʻole e ʻōlelo, ka poʻe maʻi me ka mōʻaukala o ka angioneurotic ʻO ka edema, kahi i pili me ka hoʻohanaʻana i nā lāʻauʻokoʻa'ē aʻe, me ka ACE inhibitors, vasculitis, a me Shenlain-Genocha purpura.
Mai ka pūnaehana nūhou: ʻaʻole maopopo - migraine, dysgeusia.
ʻO ka hanu, thoracic a me nā mediastinal: ʻike ʻole - ka huhū.
Mai ka hanā hana ʻana: Unknown - maʻi maʻamau, pancreatitis, luaʻi.
Mai ka ʻōnaehana hepatobiliary: loaʻa pinepine - hepatitis, ʻaʻole ʻike - hana i ʻole ka maʻi lēpaʻa.
Mai ka ʻili a me ka ʻōpala kiko: ʻike ʻole - urticaria, pruritus, ʻuma, photosensitivity, erythroderma.

Mai ka ʻōnaehana musculoskeletal a me ka hoʻopili hui: ʻike ʻole - myalgia, arthralgia, rhabdomyolysis.
Mai ka pūnaehana reproduction a me nā keli mammary: ʻike ʻole - erectile dysfunction / impotence.
Ma ka ʻāpana o nā pūpū a me ka pēpē: ma muli o ka hoʻoneʻe ʻana o ka ʻōnaehana renin-angiotensin-aldosterone, ua loli nā hana o ka renal, ʻo ia hoʻi ka maikaʻi ʻole ʻana i nā mea maʻi i ka hopena, ua hōʻike ʻia, e hiki ke loli i ka wā ke hoʻokuʻu ʻia ka mālama ʻana.
Nā maʻi noʻonoʻo: ʻike ʻole - ka manaʻo kaumaha.
Nā hōʻailona hōʻailona hana: ʻike ʻole - hyponatremia.
E na keiki . ^ E Ha yM. ʻO ka hōʻike ʻana o nā ʻōkuhi ʻino i nā keiki he like ia me nā mea maʻi. Hoʻolaha nā ʻikepili e pili ana i nā hopena ʻino i nā keiki.

Hipotina arterialia,
hyperkalemia
- huikala,
- ka lactose intolerance,
- galactosemia aiʻole glucose / galactose malabsorption syndrome,
- ka wahine hāpai
- wā lactation,
- makahiki a hiki i ka 18 makahiki (ʻaʻole i hoʻokū ʻia ka hana a me ka palekana),
- Ke kōkua o ka maʻi i ke losartan a me / me nā mea ʻē aʻe o ka lāʻau lapaʻau.
Me ka mālama pono pono lā e hoʻohana ʻia ka lāʻau lapaʻau no ka maʻi hepatic a me / a ʻole paha, i hōʻemi i ka BCC, ke kaupaona ʻana i ka wai-electrolyte kaulike, bilateral renal stenosis a i ʻole ka stenosis kūloko o hoʻokahi keiki.

Angioedema
Loaʻa paha ka hanana o ka angioedema. ʻO ka maʻi me ka angioneurotic edema (ka huki o ka maka, nā lehelehe, ka ʻāʻī, a me / a ʻōlelo paha) e nānā pinepine ʻia.
He hypotension arterial a me ka hoʻōki wai-electrolyte
ʻO ka hypotension arterial Symptomatic, ʻoiai ma hope o ka hana mua o ka lāʻau a i ʻole ma hope o ka hoʻonui ʻana i ke ʻano, e hiki mai i nā mea maʻi me ka hoʻēmi ʻana o BCC a i ka lilo ʻana o ka sodium i hoʻomake ʻia ma ka hoʻohana ʻana o ka diuretics ikaika, ka meaʻai o kaʻai o ka paʻakai ʻana, ʻeha a hoʻoheheʻe ʻia. Pono kēlā mau ʻano i ka hoʻoponopono ʻana ma mua o ka hoʻomaka ʻana i ka mālama ʻana me Lorista a i ʻole hoʻohaʻahaʻa i ka palena mua o ka lāʻau. Hoike ʻia nā loina like i nā keiki mai 6 mau makahiki.

Hoʻopiʻi ka piliona
Hōʻike pinepine ʻia ka pale ʻana o Electrolyte i nā maʻi i nā maʻi renal impaired (me a ʻole ko ka maʻi diabetes), pono e mālama ʻia.
I kahi papa noiʻi e pili ana i nā mea maʻi me ka mellitus type II me ka nephropathy, ʻoi aku ka nui o ka ulu ʻana o ka hyperkalemia me losartan i hoʻohālikelike ʻia me ka hui pletebo.
No laila, pono ʻoe e kiaʻi pono i ka nānā ʻana o ka pāhare paʻilele i loko o ke kaila koko a me ka hoʻopuka ʻana ma ka creatinine, keu i nā mea maʻi me ka hōʻoki ʻana o ka naʻau a me ka hoʻomaʻa ʻana o creatinine o 30-50 ml / min.
Hoʻohana pinepine ʻia ka hoʻohana ʻana o ka losartan a me ka potassium-sparing diuretics, pākuhi me ka paʻakai, nā mea hoʻonaninani o ka paʻakai i loko o ka paʻakai.

Hōʻeha ka hana ʻoluʻolu
Hoʻokumu i ka hōʻike i ka pharmacokinetic e hōʻike ana i ka nui o ka piʻi ʻana o ka losartan i loko o ke koko koko o nā mea maʻi me ka cirrhosis o ka ate, pono e noʻonoʻo ʻia ka hoʻēmi ʻana i ka maʻi no nā poʻe maʻi me ka mōʻaukala o ka hana a ka maʻi hemahema.
ʻAʻoheʻike i loaʻa i ka hoʻohana ʻana i ka hopena o ka losartan i nā maʻi me nā maʻi ʻehaʻeha o ke kala, no laila, ʻaʻole pono ʻo losartan e lawe i kēlā mau maʻi.
ʻAʻole kūpono ʻia ʻo Losartan no ka hoʻohana ʻana i nā keiki me ka hana pūlima hemahema.

Hola paʻa kino hana
Ua hōʻike ʻia nā hoʻololi hana o Renal, ka helu pū ʻole o ka renal, ka mea i hoʻopili ʻia me ka pani ʻana o ka renin-angiotensin system (ʻoi aku hoʻi i nā mea maʻi me ka renal-angiotensin-aldosterone system, i.e. nā mea maʻi me ka maikaʻi ʻole o ka puʻuwai a i ʻole nā ​​hanana ʻole o ka wā). . ^ E Ha yM.
Ke hōʻemi nei nā hua i ka hopena renin-angiotensin-ald testosterone e hoʻonui i ka serum urea a me ka hana ʻana i nā mea maʻi me nā bilateral renal artery stenosis a i ʻole ka stenosis o hoʻokahi artery kidney. Hiki ke loli hou i kēia mau loli i ka hana o ke keiki ma hope o ka hoʻokuʻu ʻana o ka maʻi. Pono e hoʻohana ʻia ʻo Losartan me ka akahele i nā poʻe maʻi me ka stenosis aralula renalula a i ʻole he stenosis keiki ʻole.
Hoʻohana i nā keiki me ka hana pūlea paʻa ʻole
ʻAʻole kūpono ʻia ʻo Losartan no ka hoʻohana ʻana i nā keiki me ka helu filtration glomerular

Ke ʻano o ka noi

Lorista i koho ʻia i ka hui pū me nā lāʻau lapaʻau antihypertensive, a me ka monotherapy. ʻAʻole ʻai i ka ʻai i ka hoʻopili ʻana o ka lāʻau lapaʻau.
He maʻi hypertension (AH):
ʻO kahi mahele mua o 50 mg, ma ka hapa nui he nui kēia dosis i mālama ʻia. ʻO ka dosis ʻokoʻa loa no ka hoʻohana ʻana i kēlā me kēia lā he 100 mg o Lorista. Loaʻa ka hopena kiʻekiʻe antihypertensive e 3-6 pule. hana ʻO nā mea maʻi me ka hypovolemia (ma ka laʻana, i ka wā e lawe ai i ka diuretics i nā kuʻuna nui) a i ʻole hanaʻi ʻia o nā ate, pono e hoʻemi ʻia ka pualikoa mua i 25 mg. No nā mea maʻi maʻi, ʻo nā mea maʻi me ka hana renal hōʻemi a me / a i ʻole hemodialysis, ʻaʻole pono ka hoʻoponopono ʻana.
Hōʻea nā puʻuwai naʻau:
No kēia kulekele, e noi ʻia ana ʻo titration (hoʻonui nui i ka wai): i ka pule mua, ʻae ʻia ʻo 12.5 mg o Lorista i kēlā me kēia lā, ma ka ʻelua 25 mg o ka lāʻau lapaʻau i kēlā me kēia lā, mai ke kolu o ka pule, e ʻōlelo ʻia ana kahi papa mālama maʻi o 50 mg o ka lā.
Kāohi (pale) nā hōʻeha o nā maʻi cardiovascular, me nā mea hōʻeha, i nā mea maʻi me ka nui o ka hopena (ka hypertension arterial a waiho aku ai i ka hypertrophy ventricular):

ʻO Nepropathy me ka proteinuria i nā maʻi me ka diabetes mellitus type 2:
ʻO ka ʻōmua mua o Lorista he 50 mg, inā pono, hiki ke hoʻonui ʻia ka nui i ka 100 mg.

E hoʻokuʻu i nā palapala

• 10 - blisters (3) - nā ʻeke pepa. 30 tab i i hui kūhelu 7 - blisters (14) - nā pā o ka pahu. 7 - blisters (14) - nā ʻeke pepa. 7 - blisters (2) - nā pākeke o ke kāleka. 7 - blisters (4) - nā ʻeke pepa. 7 - blisters (8) - nā ʻeke pepa. 7 - blisters (12) - nā ʻeke pepa. 7 - blisters (14) - nā ʻeke pepa.100 mg + 25 mg mau papa kiʻi ʻoniʻoni - 30 tab. 100 mg + 25 mg mau papaʻa ʻoniʻoni - 60 papa pack e 30 mau papa pakana 60 papa papa e 90 nā papa

ʻO ka wehewehe ʻana i ke ʻano dosis

• Nā papa hana hoʻoili kiʻi ʻoniʻoni, ʻōwili uhi ʻia nā kiniponi me ka melemele me kahi ʻōmaʻomato o ke kaila, he oval, he biconvex, me ka loaʻa ʻole o ka ʻaoʻao. ʻO nā papa, i ulana ʻia mai ka melemele a i ka melemele me ke kaʻe o ka pua ʻōmaʻomaʻo, he oval, he biconvex.

Nā kūlana kūikawā

• 1 kōpō pākōlio losartan 100 mg hydrochlorothiazide 25 mg Mīwīwī: nā kīpē pregelatinized - 69.84 mg, cellulose microcrystalline - 175.4 mg, mole lactose lōmole - 126.26 mg, ka pākuʻi o ka magnesium - 3,5 mg. ʻO ka mana o ka membrane film: hypromellose - 10 mg, macrogol 4000 - 1 mg, dye quinoline yellow (E104) - 0.11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. pākōlio losartan 100 mg hydrochlorothiazide 12,5 mg ʻO nā kumuwaiwai: nā māka pregelatinized, cellulose microcrystalline, lōmole lactose, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc. pākōlio losartan 100 mg hydrochlorothiazide 25 mg ʻO nā mea kuahiwi: nā māka pregelatinized, cellulose microcrystalline, lactose monohala, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc. potassium losartan 50 mg hydrochlorothiazide 12,5 mg ʻO nā mea kuʻuna: kano pregelatinized, kaila selolosa microcrystalline, lactose monohidate, magnesium stearate Shell komposisyon: hypromellose, macrogol 4000, quinoline kaila melemele (E104), titanium dioxide (E171), tal. pākōlio losartan 50 mg hydrochlorothiazide 12,5 mg ʻO nā mea kuʻina: ka huakaʻi pregelatinized, cellulose microcrystalline, lactose monohala, magnesium stearate. Hōʻuluʻulu Shell: hypromellose, macrogol 4000, quinoline kūmole melemele (E104), titanium dioxide (E171), talc.

Nā Lorista N contraindications

• Hypersensitivity a losartan, i nā lāʻau lapaʻau i loaʻa mai nā sulfonamides a me nā mea ʻē aʻe o ka lāʻau lapaʻau, anuria, pilikia ʻole o ka renal (ʻo ka creinine clearance (CC) ma mua o 30 ml / min.), Hyperkalemia, dehydration (me nā poʻe he nui o ka diuretics) lima momona hōʻeha, maʻi hipokalemia refractory, hapai, lactation, hypotension arterial, makahiki ma lalo o 18 makahiki (ʻaʻole i hoʻokō ʻia ka hopena a me ka palekana), hemahema lactase, galactosemia a glucose / gal malabsorption syndrome Nā loina. Me ka mālama akahele: nā hana hoʻoliʻiliʻi o ka wai-electrolyte (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), bilateral renal aren stenosis a i ʻole ka stenosis o hoʻokahi artery kidney, diabetes mellitus, hypercalcemia, hyperuricemia a / a i ʻole gout, i hoʻopili ʻia me kekahi anemone neurologicalal. hoʻomohala ʻia ma mua me nā lāʻau ʻē aʻe, me nā papa pale AP

Nā hopena ʻaoʻao Lorista N

• Ma ka ʻāpana o ke koko a me ka ʻōnaehana lymphatic: pinepine: anemia, Shenlane-Genokha purpura. Mai ka pānaʻi ʻana: ʻaʻole i loaʻa: nā hopena anaphylactic, angioedema (me ka uhi ʻana o ka larynx a me ka alelo, e hoʻolalelale ana i nā ala mokulele a me / a ke ʻano ʻana o ka maka, nā lehelehe, pharynx) Mai ka ʻaoʻao o ka pūnaehana nīkini waena a me nā ʻōnaehana hoʻoneʻe peripheral: mau pinepine: ka ʻeha, ka ʻōhumu a me ka hina ʻole systemic, ʻūhā, nā luhi, ka manawa maʻamau: migraine. Mai ke ʻano o ka pūnaʻi cardiovascular: pinepine: hypotension orthostatic (hilinaʻi-dosis), palpitations, tachycardia, ʻaʻole anuʻu: vasculitis. Mai ka papa hana hanu: pinepine: mauʻu, ʻihi ʻana o nā ʻōpū hanu kiʻekiʻe, ʻo ka pharyngitis, ka huehue o ka mucosa nasal. Mai ka ʻeha gastrointestinal: pinepine: nā maʻi o ka maʻi, nā dyspepsia, nausea, ka luaʻi, ka ʻeha o ka ʻōpū. Mai ka ʻōnaehana hepatobiliary: loaʻa pinepine: hepatitis, hana hana kōpaʻa hemahema. Mai ka ʻili a me ka momona o ke kūpaʻa: pinepine: urticaria, ʻeha ka ʻili o ka ʻili. Mai ka ʻōnaehana musculoskeletal a me ka hoʻopili hoʻohui: pinepine: myalgia, ʻeha ʻeha, pinepine pinepine: arthralgia. Nā mea ʻē aʻe: ka pinepine: asthenia, nāwaliwali, edema peripheral, ʻeha ʻeha. Nā hōʻailona mākaʻina: pinepine: hyperkalemia, hoʻonui ʻia o ka hemoglobin a me ka hematocrit (ʻaʻole i koʻikoʻi i loko), pinepine: hoʻonui nui ʻana i ka serum urea a me nā mea hana, maʻa pinepine loa: hoʻonui i ka hana o ka ate a me nā enzyir bilirubin.

He aha ka mea e kōkua ai

ʻO kēia kahi lāʻau lapaʻau maikaʻi no ka hui hoʻohui ʻana o ka hypertension arterial a me ka huhū ʻole o ka naʻau.

Waihoia ma keia mau hihia:

• pae hypertension pae mua ma ka wā ʻelemakule,
• ma ka Hola ana no ka mai ana o ka huelo ma na poe makua me na haipulani arertial a me na type la 2 mellitus me ka proteinuria,
• he ʻano hopena o ka puʻuwai puʻuwai, i ka hiki ʻole ke hoʻohana aku i nā mea kikoʻī ma muli o ke intolerance,
• ka pale ʻana i ka pehu me ka hoʻokiʻekiʻe ʻia o ke koko a hoʻopaʻa ʻia i ka hypertrophy left left.

Nā kūlana mālama

• hale kūʻai ma ka lumi lumi 15-25 kiʻekiʻe
• haʻalele i nā keiki

ʻO Lorista N kahi hui antihypertensive hui pū ʻia me kahi blocker angiotensin receptor blocker (type AT1) losartan a me ka thiazide diuretic hydrochlorothiazide. ʻO ka pahuhopu nui loa o ka maʻi hypertension ke pale aku i ka hoʻomohala ʻana o nā maʻi cerebrovascular, nā hanana cardiovascular, hana ʻole, a me ka hoʻēmi ʻana i ka hopena o ka make cardiovascular. Hāʻawi i ka loaʻa ʻole o ka monotherapy i ka hapanui o nā hihia ke kū nei i ka hana e hoʻokō ai i ka pae o ke kaila o ke koko, i nā makahiki i hala iho nei, ke hilinaʻi nei ka poʻe cardiologists i nā lāʻau antihypertensive hui pū. ʻO ka hui pū "angiotensin receptor blocker (sartan) + thiazide diuretic" i kēia manawa i manaʻo ʻia kekahi o nā mea hoʻohiki. ʻO ka hana like like o ka hana me ka hui "angiotensin-hoʻohuli i ka hoʻoneʻe o ka enzyme (ACE inhibitor) + thiazide diuretic", ʻo kēia "lāʻau lapaʻau" kāwili "ka nui o nā pono kūpono ʻole ma mua o ka mea mua. No laila, ʻaʻole like i ka ACE inhibitors, hāʻawi ka poʻe sartans i kahi pale piha i ka "cellular" hopena o ka hopena renin-angiotensin-aldosterone. Loaʻa iā lākou ka hoʻomanawanui iki aku, me ke kumu ʻole, ʻaʻole i ka hopena me ka ACE inhibitors, kahi ʻōpala maloʻo a me ka angioedema ma muli o ka hōʻiliʻili o ka bradykinin nui i loko o ke kino. Ua hōʻike i nā hualoaʻa o nā hoʻokolohua hoʻokolohua multicenter maʻamau i hōʻike i ka hoʻokō nui o ka losartan ma ka hypertension. Noho ʻo Sartans i kēia lā i kekahi o nā kūlana nui i nā ʻōnaehana o ke ao no ka mālama ʻana i kēia maʻi. ʻO Lorista N mai ke kahua kūʻai lāʻau lapaʻau Slovenian i puka mai ma ko mākou ʻāina i ka makahiki 2008 a i kēia manawa ua hoʻokele ia i nā lanakila o nā kauka a me ka hilinaʻi o nā maʻi. Kuhi ʻia ka hana o ka hana ʻo lorista N me ka hiki o losartan (waiho iā hydrochlorothiazide no kēia manawa) e pale i ka loaʻa ʻana o angiotensin II i kāna mau "pilikino" pilikino, ma muli o ia e ʻike i kona hiki i ke vasopressor.

A ke kumu, ua hōʻeha ke ʻano o ka lāʻau i ka hoʻomaha ʻana o nā paia o nā kīʻaha koko, e hōʻemi ai i mua a a ma hope o kaʻohi i ka myocardium, ka pale kūlohelohe peripheral ākea o nā kīʻaha koko a pale aku i ka hypertrophy hema. ʻAʻole like me nā lāʻau lapaʻau antihypertensive, ʻo Lorista N he hopena uricosuric, ʻaʻole ia e hoʻopōʻino i ka hana erectile, hōʻike i ka waiwai anti-inflammatory a me antiaggregant (antithrombotic), a hoʻomaikaʻi i nā hana cognitive (cognitive) hana. ʻO ka hana kūpono a me ka maikaʻi palekana o Lorista N i hōʻoia ʻia ʻaʻole wale nō i loko o nā hoʻokolohua lapaʻau, akā i ka wā o nā haʻawina hope-marketing, i.e. ma hope o ke komo ʻana o ka lāʻau lapaʻau i ka mākeke. Ma hope o ka hoʻopale waha, ua komo koke ʻo losartan i ka ʻeha gastrointestinal. ʻO kona bioavailability systemic kahi 33%, kahi i pili pū me ka hopena o ka hana mua ma ka ate. ʻO ka popo kiʻekiʻe ʻo losartan i ke koko ka hoʻopaʻa ʻia 1 hola ma hope o ka hoʻokele ʻana. Hiki ke hoʻohana ʻia ʻo Lorista N ma kahi o ka komo ʻana o ka meaʻai. ʻO ka māhele ʻelua o ka lāʻau - he thiazide diuretic hydrochlorothiazide - pale i ka pale ʻana i ke kū hou ʻana i ka nephron distal o nā waiwai sodium, a me ka chlorine, me ka wai a me ka pālolo, magnesium a me nā ʻonsona calcium. ʻO kona hopena antihypertensive ma muli o ka hoʻonuiʻiaʻana o ka arterioles. Hoʻomaopopo ka hopena diuretic 1-2 mau hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau, hiki i kona kiʻekiʻe ma hope o 4 mau hola a lōʻihi a hiki i 12 mau hola. ʻO ka maʻa mau (e kākoʻo ana hoʻi) i ka lorista N no ka hypertension arterial ʻo 1 papa 1 manawa i ka lā. Pono ka hopena o ka hopena therapeutic e kali i ka 3 mau pule o ka lāʻau lapaʻau. Me ka lawaʻole o ka lāʻau lapaʻau, hiki ke hoʻonui ʻia i kēia hōʻeha i nā papa ʻelua. Hele maikaʻi ʻo Lorista N me nā lāʻau lapaʻau antihypertensive. ʻAʻole pono nā poʻe maʻi i ka hoʻoponopono hoʻoponopono ʻia. ʻO ka heleʻana o ka hydrochlorothiazide i ka mākaukau e hoʻonui i ka ulu ʻana o ka hypotension arterial a me nā haunaele ma ka pae wai-paʻakai.

Me ka mālama pono

Pono e mālama pono i ka nānā ʻana i nā lāʻau lapaʻau i nā keiki a me nā ʻōpio ma lalo o 18 makahiki o ka makahiki ma muli o ka ʻike haʻahaʻa o ka hopena i ka kino o nā keiki a me kāna kūkulu.

Ma ka mālama pono a ma lalo o ka mākaʻi o nā limahana olakino, lawe ʻia nā kālā i ka wā o ka huki ʻana o nā arela renal, ma hope o ka hoʻololi ʻana i ka kidney, i ka wā liʻiliʻi ʻana o ka aorta a i ka palaka mitral, palalelele o ka paia o ka ʻaoʻao hema a ʻākau paha o ka puʻuwai, paʻa i ka hana renal i ka hōʻeha ʻana o ka naʻau, ka maʻi ʻōpū coronary, nā maʻi o nā kahe koko o ka lolo, ka hoʻonui ʻana i ka aldosterone, ka lawe ʻana i nā palena kiʻekiʻe o nā lāʻau diuretic.

Pehea e lawe ai iā Lorista 12.5

Lawe ʻia i hoʻokahi lā i ka lā, ʻaʻole ia e noʻonoʻo i ka komo ʻana o ka meaʻai (ma mua o ka wā, ma hope o ka ʻai).

Hiki i ka hoʻokele e hui pū me nā lāʻau lapaʻau antihypertensive.

Me ke kaʻe koko kiʻekiʻe, 50 mg ka mea i kuhikuhi mua ʻia, a laila, e like me kekahi mau mea maʻi, ua hoʻonui ʻia ka dosage i 100 mg i kēlā me kēia lā.

I loko o nā maʻi maʻi, ma muli o ko lākou hōʻeha a me ka papa, ʻo ka nui o ka lāʻau lapaʻau i kekahi manawa e hōʻemi ʻia i 25 mg i kēlā me kēia lā.

Ma kahi hikiʻole i ka puʻuwai naʻau, hāʻawi mua i ka 12.5 mg i kēlā me kēia lā, a laila e hoʻonui pinepine i ka 150 mg i kēlā me kēia lā, ʻo kēlā me kēia manawa ke hoʻonui i ka momona ʻelua i ʻelua me kahi manawa o hoʻokahi pule. Hoʻololi ʻia ka koho ʻana o ia ʻano ʻoihana hoʻokaho me ka diuretics a me nā glycosides cardiac.

Lawe ʻia i hoʻokahi lā i ka lā, ʻaʻole ia e noʻonoʻo i ka komo ʻana o ka meaʻai (ma mua o ka wā, ma hope o ka ʻai).

Me ka maʻi diabetes

Inā hoʻokomo ka mea maʻi i ka maʻi diabetes II me ka nui o ka protein i loko o ka urine, e pale ai i ka pono o ka dialysis a me ka make, ʻo ka make o ka maʻi lapaʻau mua ma mua o 50 mg me kahi hoʻonui o ka wā e hiki mai ana a 100 mg i kēlā me kēia lā e like me ka hopena i ka hoʻohaʻahaʻa ʻana i ke koko. ʻO ka hoʻopauʻana me ka insulin a me nā lāʻau lapaʻau e hōʻemi i ke kiʻekiʻe o ke kō (glitazone, etc.). Hoʻonohonoho ʻia e lawe i ka diuretics a me nā lāʻau antihypertensive.

Nā hopena hopena

Kahi liʻiliʻi ka hopena o ka hopena i loko o ka lāʻau lapaʻau, akā aia kekahi mau hihia i kahi hanana ka hiki ʻole o ke kino mai ke ʻano o nā kino a me nā ʻōnaehana. No laila, hiki i ka ʻōnaehana cardiovascular ke pane me ka wikiwiki o ka puʻuwai, ka neʻe ʻana i ka puʻuwai puʻuwai, etc.

ʻO ka hōʻiliʻili o Nasal, ka hana ʻana i ka larynx a me ka bronchi, nā palaka, nā ʻeha hope, nā limahana a me nā ʻūʻī, a me ka hōʻino ʻole o ka pale wai-electrolyte e ulu. Akā i ka hapanui o nā hopena he nawaliwali loa a lele i ka loli ʻana a ʻaʻole hoʻi i loli ka lāʻau.

Lapaʻau

E hui pū ʻia ka lāʻau antihypertensive.

ʻO Losartan kahi waena kūloko o ka angiotensin II ʻae i ke ʻano he II a me ka mea ʻole i protine.

In vivo and in vitro, losartan and its biologically active carboxy metabolite (EXP-3174) block all all the physiologically important effects of angiotensin II on AT 1 receptors, without way of his synt synthesis: alakaʻi ia i ka hoʻonui i ka hana renin plasma a me kahi kaohi ʻana o ke kaila o ka ald testosterone i loko o ke koko koko.

Hoʻololi ʻo Losartan i ka hana ʻana i nā mea hoʻoponopono o ka AT 2 e ka hoʻonui ʻana i ka pae o ka angiotensin II. ʻAʻole ʻo Losartan i kāohi i ka hana o ka kininase II, he enzyme e pili ana i ka metabolism o ka bradykinin.

He hōʻemi ia i OPSS, kaomi i ke kaomi pulmonary, e hōʻemi ana ma hope o ke kaumaha, he hopena diuretic.

Kūleʻa ʻia me ka hoʻomohala ʻana o ka hypertrophy myocardial, hoʻonui i ka hoʻolahalaha ʻana i nā maʻi me nā maʻi ʻoi ʻole ka maʻi.

ʻO ka lawe ʻana i ka losartan 1 ka manawa / lā alakaʻi i kahi nui statistically nui i ka systolic a me ka diastolic blood pressure. I loko o ka lā, ke kaohi nei ka losartan i ke kahe o ke koko, aʻo ka hopena antihypertensive e pili i ka ʻenikani circadian kūlohelohe. ʻO ka emi o ke kahe o ke koko i ka hopena o ka hopena o ka lāʻau lapaʻau ma kahi o 70-80% o ka hopena i ka hopena o ka lāʻau, 5-6 mau hola ma hope o ke lawelawe ʻana. ʻAʻole mālama ʻia ka maʻi kahalike, a ʻaʻohe o ka losartan i ka hopena koʻikoʻi ma o ka puʻuwai puʻuwai.

Maikaʻi ʻo Losartan i nā kāne a me nā wahine, ʻoiai ʻo ia i nā ʻelemakule (≥ 65 mau makahiki) a me nā mea maʻi ʻōpio (≤ 65 mau makahiki).

ʻO ka Hydrochlorothiazide kahi diuretic thiazide ka mea i ka hopena diuretic me ka hoʻopiʻi ʻana i ka reabsorption o ka sodium, chlorine, potassium, magnesium, nā wai wai i ka nealron neʻalone, e hoʻolei i ka hoʻopuka ʻana o nā meons calcium, uric acid. Loaʻa ia ia nā waiwai antihypertensive, ulu ka hopena hypotensive ma muli o ka hoʻonuiʻana o ka arterioles. ʻAʻohe hopena i kahi kahe koko maʻamau. Hoʻopilikia ka hopena diuretic ma hope o nā hola 1-2, hiki i kahi lōʻihi ma hope o 4 mau hola a lōʻihi i ke hola 6-12.

Ke hopena nei ka hopena antihypertensive ma hope o nā lā 3-4, akā hiki paha i nā wiki 3-4 e hoʻokō ai i ka hopena therapeutic maikaʻi loa.

Nā ʻōlelo kikoʻī

ʻO nā mea maʻi i loaʻa i mua i ka edema alema, ka lolo a ʻohi paha paha e pono ke loaʻa me ka lāʻau lapaʻau ma lalo o ka mālama ʻana o kahi kauka a no nā kumu olakino.

ʻAʻole pono e hoʻohana ʻia ka lāʻau lapaʻau e nā mea maʻi me ka aliskiren a i ʻole nā ​​aliskiren e loaʻa nei i nā lāʻau lapaʻau no ka maʻi maʻi.

Hoʻohana i ka wā hāpai a me ka lactation

I ka wā o ka hānai a me ka umauma, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau, a i ka wā i hoʻopaʻa ʻia ai ka hapai, ua kāpae koke ʻia ia, no ka mea he kuʻuna i ka ʻōpala (hypoplasia o nā pūpū a me ka ʻihi, hoʻololi i nā ʻihi, nā hana piha a ka wahine o ka pūpū, etc.). ʻO ka hopena ma nā keiki hou o ka lāʻau i hoʻopili ʻia i ka umauma umauma i aʻo ʻole ʻia, no laila, ʻaʻole e hoʻohana ʻia no ka ʻike ʻole ʻana o nā ʻano hoʻohālikelike o ke kino o ke keiki.

I ka wā lohi, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau.

Hoʻopili pū me nā lāʻau ʻē aʻe

He maikaʻi kūpono ia me hydrochlorothiazide, digoxin, warfarin, cimetidine, fenobarbital a me kekahi mau mea ʻē aʻe. Hiki i ka nui o nā diuretic ka mālama i ka diuretic a me ka hoʻomākaukau ʻana i nā paʻakai (Triamteren, Amiloride, etc.) i mea e hoʻonui ai i kēia mea i ke koko. ʻO ka hoʻohui me nā lāʻau anti-inflammatory non-steroidal hiki ke hōʻemi i ka hopena o ka lāʻau i wehewehe ʻia.

Thaizive diuretics i hui pū me ka losartan alakaʻi i kahi hāʻule pohō i ke kaomi i loko o nā ona.

Hiki i ke komo ʻana me nā lāʻau lapaʻau antihypertensive pono e hōʻemi me ke koko.

ʻO nā lāʻau lapaʻau i loaʻa ka hopena ma RAAS (Creensril, Lisinopril, etc.) hiki ke hōʻemi i ka hana renal a hoʻonui i nā kiko o ka urea a me ka hana ʻana e like me nā ʻōkuhi hana.

Hoʻolaha ka waipuna

I mea e pale aku ai i nā hopena i makemake ʻole ʻia i ka ʻōnaehana cardiovascular hiki ke hoʻohui pū ʻia me nā mea inu ʻawaʻawa. Hiki i ke hoʻohana hiki ʻana i ke kahe o ke kahe o ke koko, ka pale ʻana i nā hana o ka ʻōpū, ka ʻāʻī a me nā pēpē.

1. Angizar (India).
2. Gizaar (USA).
3. ʻO Cardomin-Sanovel (Turkey).
4. Losartan (Israel).
5. Lozarel (Switzerland).
6. Lorista ND (Slovenia).
7. Lozap me (Czech Republic).
8. Erinorm (Serbia).

Cardiologists

Arina Ivanovna, cardiologist, Omsk

Ke lawe nei i kēia lāʻau lapaʻau, pono e noʻonoʻo i nā contraindications a me nā nuances o ka lawe ʻana. Pono ka mea pono e hana i nā koho no nā poʻe me ka hana ʻole o ka renal functioning, me ka hoʻomau ʻana i ka māhele nui, me ka maʻi ʻōpio coronary, hapai a me ka umauma. He mea nui ia e hoʻomaopopo i mua o ka hopena o ka papa ʻaina e pono ai ke pale aku i ka wai ʻona no ka lōʻihi o ka mālama ʻana i kahi lā o nā lā he 5-7 a ma hope o ka pau ʻana o ka lawe i nā papa i hoʻopau ʻia nā mea mai ke kino.

Pavel Anatolyevich, cardiologist, Samara

Hoʻohana nui ia ma ka hui pū me nā lāʻau ʻē aʻe, a me kahi mea monopreparation ʻaʻole hōʻike i ka pono nui. ʻO kahi mea koʻikoʻi koʻikoʻi au e noʻonoʻo ai i ka hiki ke pale i nā keiki i nā maʻi me ka diabetes mellitus type 2 me ka proteinuria. He haʻahaʻa ke kumukūʻai, kahi e hiki ai i ka lāʻau lapaʻau ke kūpono no nā ʻāpana āpau o nā maʻi.

ʻO nā mea pōʻino ʻole i ka embryotoxicity kiʻekiʻe, kahi e hiki ai ke hoʻohana ʻia i ka wā hāpai.

Alexey Stepanovich, cardiologist, Norilsk

Wahi a nā loiloi maʻi maʻi, i hoʻomaopopo maikaʻi ʻia, hoʻohaʻahaʻa ka lohi ʻana i nā wīwī a me ka palupalu, kūpono i nā ʻōpio a me ka poʻeʻelemakule.

Ua nānā wau i nā hopena ʻaoʻao wale nō - hoʻomaka ke kāne i nā makahiki 49, ua hoʻomaka nā maʻi he maʻi, ma muli o kahi hiki ʻole iā ia ke ʻele i kahi kaʻa. I kēia hihia, ua hoʻololi ʻia ka lāʻau lapaʻau.

Andrey, 30 mau makahiki, Kursk

Ua inu ʻo ia i nā piliona e like me ka mea i hōʻike ʻia e ka lolo ahonui. ʻO ka dosis mua he 50 mg, a laila hoʻonui pinepine i ka 150 mg. Hana pono ia, ʻaʻohe hopena hopena. ʻAʻole kiʻekiʻe nā kumukūʻai.

Olga, 25 makahiki, Aktyubinsk

E ʻike i kou pilikia no ka hoʻomohala ʻana i ka maʻi diabetes!

Lawe i kahi hōʻike hoʻāʻo pūnaewele mai ka endocrinologists ʻike

ʻO ka hoʻāʻo ʻana, ʻaʻole iʻoi aku ma mua o 2 mau minuke

7 a maʻalahi
o nā pilikia

94% pololei
hoʻāʻo

10 tausani ka pōmaikaʻi
hōʻike

Hāʻawi ʻia i ka makuahine e pale i nā ʻoliva, no ka mea, ua loaʻa ʻo ia i ka maʻi diabetes me ka proteinuria. Wahi a nā mea nānā, ua maikaʻi ka maikaʻi o ka makuahine. Ma ka hoʻoponopono ʻana i nā loiloi, ua emi ka nui o ka protein i ka urine. Ua holo maikaʻi loa ka lāʻau lapaʻau a ʻaʻohe hopena maikaʻi ʻole o ka lawe ʻana i ka ʻike.

E hoʻokuʻu i ke ʻano

ʻO nā papa, i ulana ʻia mai ka melemele a i ka melemele me ke kaʻe o ka pua ʻōmaʻomaʻo, he oval, he biconvex, me kahi kakā ma ka ʻaoʻao hoʻokahi, he pā i loko o ka ʻaoʻao i ka ʻaoʻao o ke papa keʻokeʻo.

Nā mea hoʻihoʻi: nā kīʻaha pregelatinized - 34.92 mg, cellulose microcrystalline - 87.7 mg, lōpose lactose - 63.13 mg, magnesium stearate - 1.75 mg.

ʻO ka mana o ka membrane film: hypromellose - 5 mg, macrogol 4000 - 0,5 mg, ka waiʻu quinoline ʻulaʻula (E104) - 0.11 mg, titanium dioxide (E171) - 1.39 mg, talc - 0,5 mg.

10 kamepiula - blisters (3) - nā ʻeke pepa.
10 kamepiula - nā kāmele (6) - nā kīwaha o ke kāleka.
10 kamepiula - nā kāmele (9) - nā kīʻaha o ke kāleka.

Lawe ʻia ka lāʻau lapaʻau ma ke ʻano, me ke ʻano o ka ʻaina. Hiki ke hoʻohui pū iā Lorista N me nā mea hana antihypertensive'ē aʻe.

Me ka hypertension arterial, ʻo ka mua a me ka mālama mālama i ka papa. 1 lā / lā lā Loaʻa ka hopena antihypertensive kiʻekiʻe i loko o 3 mau pule o ka maʻi. No ka hoʻokō ʻana i kahi hopena i haʻi hou ʻia, hiki ke hoʻonui i ke ʻano o ka lāʻau i ka 2 tab. 1 lā / lā lā ʻO ka papa ʻōlelo nui loa i kēlā me kēia lā he 2 papa.

Me ka hoʻoneʻe ʻana o BCC (no ka laʻana, kūʻē i ke ʻano o ka lawe ʻana i nā diuretics i nā wai kiʻekiʻe), ʻo ka pona i ʻōlelo mua ʻia o ka losartan i nā mea maʻi me ka hypovolemia he 25 mg 1 manawa / lā. Ma kēia e hoʻomaka ai, pono e hoʻomaka ʻia ka lāʻau ʻo Lorista N ma hope o ka hoʻokuʻu ʻana o nā diuretics a hoʻoponopono ʻia ʻo hypovolemia.

I nā mea maʻi a me nā mea maʻi me ka maikaʻi ʻole o ka renal moderole (CC 30-50 ml / min), me nā mea maʻi ma ka dialysis, ʻaʻohe koi o ka hoʻoponopono hoʻoponopono mua.

No ka hōʻemi i ka hopena o ka morbidity cardiovascular a me ka make ma nā poʻe maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular, ʻo ka paila mua loa o ka losartan he 50 mg 1 manawa / lā. ʻO nā mea maʻi ʻaʻole i hiki i ka hiki ke hoʻokō i ka pae hoʻokele o ke koko aʻo ka lawe ʻana i ka losartan 50 mg / lā e koi ana i ka mālama ʻia e ka hoʻohui ʻana i ka losartan me nā haʻahaʻa haʻahaʻa o ka hydrochlorothiazide (12.5 mg), a inā pono, e hoʻonui i ka maʻa o losartan i 100 mg i hui pū me ʻO ka hydrochlorothiazide ma kahi o 12,5 mg / lā, i ka wā e hiki mai ana - e hoʻonui i ka nui o Lorista N i nā papa ʻelua. 1 lā / lā lā

Ke keu

Nā hōʻailona: ka hōʻailona hōʻemi i ke kahe o ke koko, tachycardia, bradycardia ma muli o ka parasympathetic (vagal) hōʻeuʻeu.

Hoʻomaʻomaʻo: nā diuresis ikaika, therapy tohu, hemodialysis hiki ʻole.

Nā hōʻailona: nā maʻi maʻamau ka maʻi maʻamau ma muli o ka nele o ka electrolyte (hypokalemia, hypochloremia, hyponatremia) a me ka dehydration ma muli o ka diuresis nui. Me ka hoʻomohokoke ʻana o ka glycosides cardiac, hiki i ka hypokalemia ke hoʻonāukiuki i ka papa o nā arrhythmias.

Hoʻohana: naʻau maʻi.

Pehea e hoʻohana ai iā Lorista N no ka maʻi maʻi. Hoʻokomo i nā papa lāʻau Geotar

Aia nā ʻaoʻao i nā ʻōkuhi no ka hoʻohana ʻana Nā Lorists . ^ E Ha yM. Loaʻa ia ma nā ʻano like ʻole o ka lāʻau (12.5 mg, 25 mg, 50 mg a me nā papa 100 mg, N a me ND me nā diuretic hydrochlorothiazide), a loaʻa nō hoʻi ia nā helu analogues. Ua hōʻoia ʻia kēia loiloi e nā loea. Waiho i kāu ʻikepili e pili ana i ka hoʻohana ʻana iā Lorista, nāna e kōkua i nā malihini ʻē aʻe i ka pūnaewele. Hoʻohana ʻia ka lāʻau lapaʻau no nā maʻi like ʻole (e hōʻemi i ke kaomi ma ka hypertension arterial). He nui nā hopena o ka ʻaoʻao a me nā hiʻohiʻona o ka hoʻopili ʻana me nā mea ʻē aʻe. ʻOkoʻa nā ʻano o ka lāʻau lapaʻau no nā pākeke a me nā keiki. He paʻa i ka hoʻohana ʻana o ka lāʻau lapaʻau i ka wā hāpai a i ka wā lactation. Hiki ke kuhikuhi ʻia ka hoʻomaʻamaʻa ʻana o Lorista e kekahi kauka kūpono. Hiki i ka lōʻihi o ke olakino ke ʻano a hilinaʻi ma ka maʻi kūikawā.

Nā ʻōkuhi no ka hoʻohana a me ka helu ʻana

Lawe ʻia ka lāʻau lapaʻau ma ke ʻano, me ka mea ʻole i ka ʻai, ʻo ke alapine ʻana o ka hoʻokō - 1 manawa i kēlā lā

Me ka hypertension arterial, ʻo ka awelika o ka awelika o kēlā me kēia lā he 50 mg. Loaʻa ka hopena kiʻekiʻe antihypertensive i loko o 3-6 mau pule o ka maʻi. Hiki ke hoʻokō i kahi hopena hou aʻe ma o ka hoʻonui ʻana o ka make o ka lāʻau i ka 100 mg i kēlā me kēia lā i ʻelua mau hopena a i ʻole hoʻokahi pae.

ʻOiai e lawe ana i ka diuretics i nā koina kiʻekiʻe, ʻoi ʻia e hoʻomaka i ka hoʻoulu ʻia ai ʻo Lorista me 25 mg i kēlā me kēia lā ma kahi hoʻokahi.

ʻO nā maʻi ʻōpiopio, nā mea maʻi me ka hana renal impaired (me nā mea maʻi i ka hemodialysis) pono pono e hoʻoponopono hou i ka hopena mua o ka lāʻau.

I nā maʻi me ka pīhoihoi hana ʻōmaʻomaʻo, e pono ke kuhikuhi i ka lāʻau ma kahi haʻahaʻa.

Ma ka hana hema ʻana o ka puʻuwai, ʻo ka hoʻomaka mua ʻana o ka lāʻau lapaʻau he 12.5 mg i kēlā me kēia lā i kahi pākahi. I mea e hoʻokō ai i ka nui o ka mālama maʻamau o 50 mg i kēlā me kēia lā, pono ke hoʻonui ʻia ka nui o ka make, ma waena o 1 hebedoma (no ka laʻana, ʻo 12.5 mg, 25 mg, 50 mg no ka lā). Kūkā ʻia ʻo Lorista i ka hui pū me ka diuretics a me nā glycosides cardiac.

No ka hōʻemi i ka hopena o ka hōʻeha ma nā maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular, ʻo ka paila palena mua o 50 mg i kēlā me kēia lā. I ka wā e hiki mai ana, hiki ke hoʻohui ʻia ka hydrochlorothiazide i nā haʻahaʻa haʻahaʻa a / a i ʻole ke momona a Lorista e hoʻonui ʻia i 100 mg i kēlā me kēia lā.

No ka pale aku i nā kauā i nā maʻi me ka diabetes type type 2 me ka proteinuria, ʻo ke ʻano kaulike mua mua o Lorista he 50 mg i kēlā me kēia lā. Hiki ke hoʻonui ʻia ka hopena o ka lāʻau i ka 100 mg i kēlā me kēia lā, e noʻonoʻo ai i ka emi ʻana o ke koko.

Nā Papa 12,5 mg, 25 mg, 50 mg a me 100 mg.

Lorista N (hoʻohui pū ʻia ka 12.5 mg o hydrochlorothiazide).

Lorista ND (hoʻohui ʻia he 25 mg o ka hydrochlorothiazide).

ʻO nā pākuʻi + Losartan potassium.

ʻOsi ka ʻaiā losartan + hydrochlorothiazide + nā mea hanohano (Lorista N a me ND).

Lorista - Angiotensin selectile 2 mau receptor antagonist ʻano AT1 i ʻole nā ​​kaine-protina.

ʻO Losartan (ka hana ikaika o ka lāʻau Lorista) a me kāna metabolito carboxy hoʻoikaika (EXP-3174) i kāohi i ka hopena o ka physiologically nui o ka angiotensin 2 ma nā mea hoʻokipa AT1, me ka mea o ke ala o kāna synthesis: alakaʻi ia i ka hoʻonui ʻana i ka hana renin plasma a me kahi laʻa i ka hoʻoliʻi ʻana o ka ald testosterone i loko o ke kaila koko.

Ma kahi kūwaho kūwaho ʻo Losartan i ka hana ʻana o nā mea hōʻiliʻili o ka AT2 ma o ka hoʻonui ʻana i ka pae o ka angiotensin 2. ʻAʻole i ʻoka ʻo Losartan i ka hana o ka kininase 2, kahi kinehu i hoʻopili ʻia i ka hana o ka bradykinin.

He hōʻemi ia i OPSS, kaomi i ke kaomi pulmonary, e hōʻemi ana ma hope o ke kaumaha, he hopena diuretic.

Kūleʻa ʻia me ka hoʻomohala ʻana o ka hypertrophy myocardial, hoʻonui i ka hoʻolahalaha ʻana i nā maʻi me nā maʻi ʻoi ʻole ka maʻi.

Loaʻa ia ʻo Lorista hoʻokahi manawa i ka lā e alakaʻi i kahi emi nui o ka systolic a me ka diastolic blood pressure. I loko o ka lā, ke kaohi nei ka losartan i ke kahe o ke koko, aʻo ka hopena antihypertensive e pili i ka ʻenikani circadian kūlohelohe. ʻO ka emi o ke kahe o ke koko i ka hopena o ka hopena o ka lāʻau lapaʻau ma kahi o 70-80% o ka hopena i ka hopena o ka lāʻau, 5-6 mau hola ma hope o ke lawelawe ʻana. ʻAʻole mālama ʻia ka maʻi kahalike, a ʻaʻohe o ka losartan i ka hopena koʻikoʻi ma o ka puʻuwai puʻuwai.

Maikaʻi ʻo Losartan i nā kāne a me nā wahine, ʻoiai ʻo ia i nā ʻelemakule (≥ 65 mau makahiki) a me nā mea maʻi ʻōpio (≤ 65 mau makahiki).

ʻO ka Hydrochlorothiazide kahi diuretic thiazide ka mea i ka hopena diuretic me ka hoʻopiʻi ʻana i ka reabsorption o ka sodium, chlorine, potassium, magnesium, nā wai wai i ka nealron neʻalone, e hoʻolei i ka hoʻopuka ʻana o nā meons calcium, uric acid. Loaʻa ia ia nā waiwai antihypertensive, ulu ka hopena hypotensive ma muli o ka hoʻonuiʻana o ka arterioles. ʻAʻohe hopena i kahi kahe koko maʻamau. Hoʻopilikia ka hopena diuretic ma hope o nā hola 1-2, hiki i kahi lōʻihi ma hope o 4 mau hola a lōʻihi i ke hola 6-12.

Ke hopena nei ka hopena antihypertensive ma hope o nā lā 3-4, akā hiki paha i nā wiki 3-4 e hoʻokō ai i ka hopena therapeutic maikaʻi loa.

ʻO nā pharmacokinetics o losartan a me hydrochlorothiazide me ka hoʻohana like ʻole i ʻokoʻa ʻole i ko lākou hoʻohana ʻokoʻa.

Ua hoʻonoono maikaʻi ʻia mai ka papa hana ʻole. ʻO ka lawe ʻana i ka lāʻau me ka meaʻai, ʻaʻohe hopena koʻikoʻi ʻoi loa e pili ana i ka serum. ʻAʻole aneane e komo i ke koko-lolo (BBB). Ma kahi o 58% o ka lāʻau ua hoʻopau i ka bile, 35% - i loko o ka pāʻai.

Ma hope o ka lawelawe waha, ʻo ka hoʻokomo ʻana o ka hydrochlorothiazide, ʻo 60-80%. ʻAʻole i hoʻohālikelike ʻia ka Hydrochlorothiazide a ua lawe wikiwiki ʻia e nā keiki.

• haehae maʻi
• hōʻemi iki i ka hopena o ka maʻi ma nā maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular,
• ka huhū o ka puʻuwai kūpilikiʻi (ma ke ʻano he hui hoʻohui, me ka intolerance a i ʻole ka launa ʻana o ka maʻi me ka ACE inhibitors),
• ka pale ʻana i ka hana kidney ma nā mea maʻi me ka diabetes mellitus type 2 me ka proteinuria i hōʻemi ʻia i ka proteinuria, e hōʻemi i ka holomua o ka hōʻeha o ka pūpū, e hōʻemi ana i ka hoʻoulu ʻana i ka ʻōpū (pale i ka pono o ka dialysis, ʻānō e hoʻonui ka serum creatinine) a i ka make.

• haehae
• hyperkalemia
• huehue
• lactose intolerance,
• galactosemia aiʻole glucose / galactose malabsorption syndrome,
• hapai
• lactation
• a hiki i nā makahiki 18 a (ʻaʻole i hoʻokumu ʻia ka pono a me ka palekana i nā keiki),
• hypersensitivity a losartan a me / a me nā mea ʻē aʻe o ka lāʻau lapaʻau.

ʻO nā mea maʻi me ka hoʻohaʻahaʻa nui o ke koko kahe (no ka laʻana, i ka wā o ka mālama ʻana me nā dosis nui o ka diuretics) e ulu i ka hypotension hypertension arterial. Ma mua o ka lawe ʻana i ka losartan, pono ia e hoʻopau i nā hōʻino i kēia manawa, a hoʻomaka e hoʻomaka i ka lāʻau me nā dosis liʻiliʻi.

I nā mea maʻi me ka cirrhosis māmā a me ka maʻalahi o ka ate, ka ʻike ʻana o ka losartan a me kāna metabolite hoʻoikaika i ka plasma koko ma hope o ka lawelawe ʻana i ka waha i ʻoi aku ka kiʻekiʻe ma mua o nā mea olakino. No laila, e hāʻawi ʻia nā mea maʻi me ka mōʻaukala o ka maʻi maʻa i kahi haʻahaʻa o ka maʻi.

I ka poʻe maʻi me ka hana renal impaired, me ka ʻole a me ka ʻole o ka maʻi diabetes, ulu pinepine ka hyperkalemia, kahi e noʻonoʻo ʻia ai, akā wale nō i nā hihia hanana ka hopena o kēia hopena, ua pau ka mālama ʻana. I ka wā o ka mālama ʻana, mālama pono ʻia ka paʻū o ka pāhana i loko o ke koko, ʻoi aku ka nui o nā poʻe maʻi maʻi, me ka hana ʻole o ka renal.

Hiki i nā lāʻau lapaʻau e hana ana i ka ʻōnaehana renin-angiotensin hiki i ka serum urea a me ka creatinine i loko o nā mea maʻi me ka bilateral renal artery stenosis a i ʻole ka ʻaoʻao lua i ka stenosis hoʻokahi o ke akeʻa. Hiki ke hoʻololi hou ʻia nā loli ʻana ma hope o ka hoʻokuʻu ʻana i ka maʻi. I ka wā mālama, pono e nānā pinepine i ka ʻike ʻana o ka creatinine i loko o kahi serum koko i nā manawa maʻamau.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a kāohi i nā mīkini

ʻAʻohe ʻikepili e pili ana i ka hopena o Lorista i ka hiki ke hoʻokau i nā kaʻa a i ʻole nā ​​ʻano ʻenehana ʻē aʻe.

• āhāhuʻe
• ʻaiaiaia
• lie kanikela
• mea momona
• ʻōpala
• hopohopo
• hiamoe a hiamoe ʻole
• hiamoe
• nā hoʻomanaʻo hoʻomanaʻo
• peripheral neuropathy,
• aloha
• hale hoʻokaumaha
• migraine
• hāpau
• manaʻo ʻino
• orthostatic hypotension (dosis-hilinaʻi),
• puʻuwai puʻuwai
• tachycardia
• brieociaia
• nā arrhythmias
• ʻinalelo angina pectoris
• ihu ʻōpala
• huhū
• ʻOluomini
• ka ʻōpū ʻana o ka muha,
• paila, mamaila,
• nā ninia
• ʻeha ka ʻōpū
• anorexia
• ka malo maloʻo
• nūloʻā
• he ʻano hūnā
• constipation
• koi aku i ka urinate
• huakaʻi renal function,
• hoʻemi i ka libido
• huakai
• nahoa
• ʻeha ma hope, ʻāʻī, nā wāwae,
• kani ana i na pepeiao
• nā kuhi hewa
• ʻike maka
• konohiki
• anemia
• ʻO ka poni Shenlein-Genoch
• maloʻo maloʻo
• hoʻonui hoʻonui ʻia
• alopecia
• kohola
• urticaria
• ʻili ka ʻili
• angioedema (me ka komo ʻana o ka larynx a me ka alelo, e hoʻopiʻi ai i nā ʻōhua o ke ala a me / a me ka haki ʻana o ka maka, nā lehelehe, pharynx).

ʻAʻole ke ʻano o nā hōʻuluʻulu maʻi o ka maʻi me ka hydrochlorothiazide, digoxin, kūlohelohe anticoagulants, cimetidine, phenobarbital, ketoconazole a me ka erythromycin i nānā ʻia.

I ka wā o ka hoʻohana mua ʻana me ka rifampicin a me fluconazole, kahi i hoʻemi ʻia i ka pae o ka metabolite ikaika o ka potassium losartan. ʻAʻole maopopo ka hopena o nā maʻi maʻi o kēia hanana.

Hoʻohana i ka manawa like me ka diuretics potassium-sparing (no ka laʻana, spironolactone, triamteren, amiloride) a me ka hoʻomākaukau ʻana i ka paʻakai ka hoʻonui ʻia ʻana o ka hopena o ka hyperkalemia.

ʻO ka hoʻohana like ʻana o nā lāʻau anti-inflammatory non-steroidal, me nā mea koho meli COX-2, hiki ke hōʻemi i ka hopena o ka diuretics a me nā lāʻau antihypertensive.

Inā ʻōlelo ʻia ʻo Lorista i ka manawa like me ka thiazide diuretics, ʻo ka emi ʻana o ke koko, ʻoi aku ka pili o ke ʻano ma ke ʻano. Hoʻonui (kūleʻa) i ka hopena o nā lāʻau antihypertensive a pau (diuretics, beta-blockers, sympatholytics).

Nā hōʻike o ka lāʻau Lorista

Hoʻololi nā kumu hoʻohālike o ka waiwai ikaika:

• Blocktran
• Brozaar
• Vasotens,
• Vero Losartan
• Zisakar
• Hanohano Sanovel,
• Karzartan
• Keola
• Lakea
• Lozap,
• Lozarel
• Losartan
• Pākana kala,
• Kālehu
• Lotor
• Presartan,
• Renicard.

ʻŌpū a me ka lactation

ʻAʻohe ʻikepili i ka hoʻohana ʻana iā Lorista i ka wā hāpai. Hoʻololi i ka pūnao Renal o ka pūpū, ka mea e hilinaʻi ana i ka hoʻokumu ʻana o ka ʻōnaehana renin-angiotensin, e hoʻomaka i ka hana ma ka lāʻomaʻo 3 a ʻoi ka hapai. Hoʻonui ka hakakā i ka pūpiki i ka wā e lawe ai i ka losartan i ka trimesters 2 a me 3. Ke hāpai ʻia ka hapai, hiki ke hoʻokuʻu koke i ka lāʻau losartan.

ʻAʻohe ʻikepili i ka hāʻawi ʻana i ka losartan me ka waiū umauma. No laila, ʻo ka nīnau no ke kāpae ʻana i ka hōʻeha umauma a wehe paha i kahi loina me ka losartan e pono e hoʻoholo i ka noʻonoʻo ʻana i kona mea nui i ka makuahine.

ʻO ka hōʻeha o ke kanaka hou - nā maʻi cardiovascular e lilo i ʻōpio i kēlā me kēia makahiki. Wahi a nā helu helu, ua pilikia kēlā me kēia kanaka ʻekolu o ka honua i ke hypertension, a ua loaʻa i kēlā me kēia kanaka o ka Honua ka lele i loko o ke koko i ka manawa hoʻokahi. I ka nui o nā lāʻau i laila no ke kaomi kiʻekiʻe, makemake wau e koho i ka mea e hana a hoʻihoʻi i ke kanaka i ke ola maʻamau. Nā ʻōnaʻi no ka hoʻohana ʻana i ka lāʻau lapaʻau Lorista N E ʻae iā ʻoe e nānā i nā pono a me nā hōʻino o ka lāʻau lapaʻau, e kōkua ana i ke koho ʻana i ka mālama kūpono ma ke alo o ka maʻi hypertension.

E hoʻohana i kahi pono e hoʻemi i ke koko i ka maʻi hypertension. ʻO ka mea hana - ka losartan he hopena hypertensive, e hōʻemi ana i ka luhi o ka nui o ke kuamo voli peripheral a loaʻa iā ia kahi hopena diuretic. Mālama ka māhele i ka myocardium mai ka hoʻomohala ʻana o ka hypertrophy a hoʻonui i ka hiki i ke kanaka me ka hoʻoikaika kino.

Ke kōkua nei ka pākahi o kēlā me kēia lā i ka mālama i ke koko ma ke ao holoʻokoʻa o ka lā. Loaʻa ka piʻi kiʻekiʻe o kāna hana i ka 4-5 mau hola ma hope o ka nānā ʻana.

No ka hoʻokō ʻana i ka emi mau o ka pomi, pono e lawe ʻia i ka lāʻau i loko o hoʻokahi mahina, a e ʻike ʻia ka hopena mua ma ke kolu o ka lā o ka hoʻokomo.

Ua hoʻopau ʻia ʻo Lorista N - me ka bile e pili ana i 58%, me ka urine - 35%.

• me ka hypertension ma ka hui pūnaʻi ʻana,
• e hōʻemi i ka make ma mua o ka hypertension arterial e paʻakikī e ka hypertrophy hema.

Nā ʻōkuhi no ka hoʻohana a me ka helu ʻana

Lawe i ka lāʻau lapaʻau i ke kakahiaka, i hoʻokahi lā, i ke ʻano, me ka manaʻo ʻole o ka kau ʻana i ka meaʻai. Ma ke kānāwai, hui pū ʻia ka hana me nā lāʻau ʻē aʻe i hoʻolālā ʻia e hoʻohaʻahaʻa i ke koko. E inu i kahi papa me ka liʻiliʻi liʻiliʻi.

Hoʻomaka e lawe ana me ka liʻiliʻi liʻiliʻi o 50 mg. Hoʻomaka ka hopena kiʻekiʻe o ka lāʻau i hope ma hope o 3-6 mau pule o ka hoʻohana mau ʻana.

Inā pono, e hoʻonui i ka huakaʻi iā 100 mg, ka mea i lawe ʻia ma ke ʻano he hoʻokahi me i ʻelua mau wai - i kakahiaka a i ke ahiahi.

Inā hui pū me ka hoʻohana ʻana i ka diuretics, a laila ʻo ka dosis mua o Lorista N he 25 mg.

I mua o ka hikiʻole o ka puʻuwai, hoʻomaka ke lawe ʻia ka lāʻau me ka 12.5 mg, a hoʻonui nui ka ʻāpana i ka 50 mg. No ka laʻana, no ka hebedoma mua loa, lawe ka mea maʻi i ka 12.5 mg o ka lāʻau i hoʻokahi manawa i ka lā, ʻo ka lua o ka pule ua hoʻonui ʻia ka nui o ka 25 mg, a i loko o ke kolu o ka pule a 50 mg.

No ka hōʻemi ʻana i ka pilikia o ka huki, hoʻomaka ka lāʻau lapaʻau ma 50 mg, a ma hope oʻelua pule he nui ka dosis a 100 mg. Hoʻolālā ʻia nā papa hana like ʻole e lawe i ka lāʻau lapaʻau no nā poʻe maʻi i loaʻa i ka maʻi maʻi 2.

No ka mālama maʻi, hiki ke kuhikuhi ʻia ka lāʻau lapaʻau no ke ola.

Nā hopena hopena

Ma keʻano holoʻokoʻa, ʻae maikaʻi ʻia ka lāʻau lapaʻau e nā maʻi, akā naʻe, i ka lawe ʻia ʻana, hiki paha i nā hopena hopena ke hōʻike i ko lākou iho iho:

• nā ʻōpū, ka migraines a me ka ʻōpū,
• ninaki a me ka luaʻi
• ʻO ka hopohopo a me ka hiamoe hiamoe,
• ʻaiaiaia
• luhi a luhi,
• nā manaʻo kaumaha a me nā hana hoʻomanaʻo,
• ka pale ʻana o ka hoʻoweliweli ʻana i loko o nā wāwae,
• nāwālima lima a me nā manamana wāwae,
• ʻeha ka puʻuwai puʻuwai
• kauha,
• ke hiʻohiʻona o ka bronchitis a me ka ʻōpala,
• ʻeha ka ʻōpū, papatolo, ʻeha a i ʻole ka constipation,
• anorexia
• ka malo maloʻo
• nā lūlū
• nahoa
• ʻeha a me ka ʻeha hoʻi
• ke kani ʻana i nā pepeiao, nā mea ʻono a me ka ʻike.
• anemia
• konopaea,
• kohola
• māhuahua kaʻe
• nā ʻano maʻi like ʻole (itching, urticaria, rash, ʻōpū o nā lehelehe, larynx, ʻōlelo), etc.

Inā i holo a i ʻole kekahi o nā hōʻailona aʻe ma luna nei, pono ʻoe e kāpae i ka lawe ʻana i ka lāʻau lapaʻau a nīnau aku i kāu kauka.

ʻO ke kumukūʻai o ka lāʻau lapaʻau 50 mg ma nā lāʻau lapaʻau ma ka pūnaewele:

• 90 papa - 641 mau rubles,
• 60 papa - 435 rubles,
• 30 papa - 281 mau rubles.

Hiki ke kūʻai ʻia kahi ʻai o 100 mg ma ke kumukūʻai i lalo.

• 90 papa - no 769 mau rubles,
• 30 kumukuai uku 355 rubles.

Hiki ke loli iki ka uku o ka lāʻau lapaʻau, ma muli o ka wahi a me ke pūnaewele lāʻau lapaʻau.

Nui nā lāʻau lapaʻau e like me Loriste N me ka pūnaehana like a me ka hopena. ʻAʻohe mea i hōʻike inoa i ia mau mea āpau, no ka mea ua like kā lāua like me ka hana a me ke ʻano. E ʻōlelo ʻia ma lalo nei nā mea kaulana loa o lākou.

Mai ka papa i luna ke ʻike ʻia nā ʻaina like ʻole o ka lāʻau lapaʻau ʻo Lorista N, ʻaʻohe hewa nui, a me nā ʻokoʻaʻane i ʻike wale ʻia ma nā kumukūʻai a me nā mea hana.

ʻAno lāʻau

Loaʻa ka lāʻau lapaʻau "Lorista" i nā ʻano like ʻole: ma ke ʻano o ka hoʻomākaukau ʻana i hoʻokahi māhele "Lorista", i hoʻohui ʻia nā ʻano o "Lorista N" a me "Lorista ND", i ʻokoʻa i ka hopena o nā mea ikaika. Loaʻa nā ʻaoʻao ʻelua o ka lāʻau i ka hopena antihypertensive a loaʻa kahi hopena diuretic.

Loaʻa nā papa papa ʻaina Lorista i ka papa hana hoʻokahi i loko o ʻekolu mau huina e loaʻa ai ka ʻano hana ikaika o ka pāhare losartan 12.5 mg, 25 mg, 50 mg pākahi. E like me nā mea kōkua, ka palaoa a me ka pregelatinized starch, kahi hui ʻana o ka waiū waiū me ka cellulose, aerosil, magnesium stearate e hoʻohana ʻia. ʻO ka membrane kiʻiʻoniʻoni o nā dosage o 25 mg a 50 mg o ka potassium losartan ka mea o ka hypromellose, talc, propylene glycol, titanium dioxide, a me kahi wai melemele quinoline i hoʻohana pū ʻia no kahi mahele o 12,5 mg.

Hōʻike ʻia nā papa o Lorista N a me Lorista ND i kahi kumu a me kahi mea hōʻemi. ʻO ka mea nui ka ʻelua o nā hana ikaika: potassium losartan 50 mg (no ka palapala N) a me 100 mg (no ka palapala N) a me ka hydrochlorothiazide 12.5 mg (no ka ʻano "N") a me 25 mg (no ke ʻano "N"). No ka hoʻokumuʻana o ka lula, ua hoʻohana ʻia nā mea hoʻohui ʻē aʻe ma ke ʻano o ke kōpaʻa pregelatinized, cellulose microcrystalline, kōmole waiū, stearate magnesium.

Hoʻopili ʻia nā papa ʻĀkau o Lorista N a me Lorista ND me kahi pani kiʻi ʻoniʻawe e pili ana i ka hypromellose, macrogol 4000, ka pulu melemele quinoline, nā titanium dioxide a me ka talc.

Pehea e hana ai ka lāʻau lapaʻau?

ʻO ka hui hoʻohui antihypertensive (ʻo Lorista ka lāʻau) e wehewehe i nā ʻōkuhi no ka hana lāʻau lapaʻau o kēlā me kēia mahele.

ʻO kekahi o nā mea hana e pau ai ka losartan, ka mea e hoʻohana ai me ka ʻoi i ke anagonist koho o ka ʻano kaiotiotinin enzyme 2 ma nā ʻaleʻa ʻole-protein.

Ua hōʻike ʻia ka vitro a me nā haʻawina holoholona i ka hana a losartan a me kāna metabolbox carboxyl e kālele ana no ka pale ʻana i nā hopena o ka angiotensin ma luna o nā mea hoʻonaninau type 1. Hoʻopau kēia i ka renin i loko o ka kaila koko a hana i ka hoʻokaʻawale ʻana i ke kao o ka aldosterone i loko o ka serum koko.

Ke kumu o ka hoʻonui ʻana i ka ʻike o ka angiotensin ʻano 2, hoʻonanea ka losartan i nā ʻenehana o kēia enzyme, ʻo ka manawa like ʻaʻole ia e hoʻololi i ka hana o ke ʻano kininase type 2 i komo i ka metabolism o ka bradykinin.

ʻO ka hana o ka hana ikaika o ka lāʻau 'Lorista' e kuhikuhi ana i ka hoʻemi ʻana i ka pale kaua peripheral piha o ka moe vascular, ka pume ʻana i loko o nā moku o ka pīhoihoi pulmonary, afterload, a me ka hoʻolako i ka hopena diuretic.

ʻAʻole ia i ʻae ʻia i ka ulu ʻana o kahi ulu pathological i ka ʻōpū puʻuwai, hoʻonui i ka kūʻē i ka hana kino o ke kino o ke kanaka, ka mea i ʻike ʻia ai ka hina ʻana o ka puʻuwai.

ʻO ka hoʻohanaʻana i kēlā me kēia lā i kahi pākahi o losartan e hoʻoulu i ka emi mau o ka puʻu kiʻekiʻe (systolic) a me ka haʻahaʻa (diastolic) i ke koko. Iloko o ka lā, ma lalo o ka mana o kēia mau mea, e kāʻili wale ʻia ke kahe o ke koko, a me ka hopena antihypertensive e kū pū me ka ritela circadian kūlohelohe. ʻO ka emi ʻana o ke kaomi o ka hopena o ka hala o ka losartan he 80% hoʻohālikelike ʻia me ka hana kiʻekiʻe o ka hana ikaika. Me ka mālama lapaʻau ʻana, ʻaʻohe hopena o ka puʻuwai puʻuwai, a ke hoʻokō nei ʻoe i ka lawe ʻana i ka lāʻau lapaʻau, ʻaʻohe hōʻailona o ka haʻalele ʻana i ka lāʻau. ʻO kaʻoi aku o ka maikaʻi o losartan e pili i ke kino kāne a me ka wahine o nā makahiki āpau.

Ma ʻāpana o ka huina i hoʻohui ʻia, ka hana o ka hydrochlorothiazide e like me ka diuretic thiazide e pili ana i ka hoʻopili ʻana o ka chlorine, sodium, magnesium, potassium a me nā wai wai i loko o ka urine mua, e hoʻi hou i loko o ke koko koko o ka nephron kidney distal. Hoʻonui ka waiwai i ka hoʻomauʻana o ka calcium a me ka uric acid e ka ion. Hōʻike ka Hydrochlorothiazide i nā waiwai antihypertensive ma muli o ka hoʻonuiʻia o ka arterioles. Hoʻomaka ka hopena diuretic ma hope o 60-120 mau minuke, a me ka hopena diuretic loa ma ka 6 a 12 mau hola. ʻO ka hopena antihypertensive maikaʻi loa e mālama ai me ka lāʻau lapaʻau e hiki mai ana ma hope o 1 mahina.

He aha ia e hoʻohana ai i ka?

ʻO ka lāʻau "Lorista", papa, kuhikuhi no ka hoʻohana ʻana i ke hoʻohana ʻana i ka hoʻohana o:

• no ka mālamaʻana i ka hypertension arterial, kahi i hōʻike ʻia ai ke kahua hui.
• e hōʻemi ana i ka hopena o nā maʻi o ka pūnaehana cardiovascular a me ka helu o ka make me nā loli a me ka hoʻololi ʻana i ka loli o ka pathological.

Nā hiʻohiʻona noi

I ka wā e mālama ai me ka lāʻau lapaʻau "Lorista" (nā papa), nā ʻōkuhi no ka hoʻohana ʻana iā ʻoe e lawe pū hou i nā lāʻau antihypertensive. No nā poʻeʻelemakule, ʻaʻole pono kahi koho kūikawā o ka inea mua.

Hiki i ka hana a ka lāʻau lapaʻau ke alakaʻi i ka piʻi ʻana o ka ʻike o ka creatinine a me urea i ka serum koko o nā poʻe maʻi e loaʻa ana i ka stenosis bilateral renal stenosis a i ka stenosis artery o hoʻokahi keiki.

Ma lalo o ka mana o ka hydrochlorothiazide, hoʻonui ʻia ka hypotension, hoʻomaikaʻi ʻia ka pale o ka electrolyte, ʻike ʻia e ka hoʻemi ʻana i ka nui o ke kahe koko, hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia. Hoʻomaopopo ka hopena o ka diuretic i ka hoʻonui ʻana i ka kolamu o ka kolamu a me ka triglycerides, ke hoʻololi ʻana i ka hoʻomanawanui o ke kino i nā kinemona glucose, e hōʻemi ana i ka hoʻōki ʻana o nā calcium calcium i ka urine, ka mea e alakaʻi ai i ka hoʻonui i ka serum koko. Hiki i ka Hydrochlorothiazide ke hoʻoulu i ka hyperuricemia a me ka gout.

ʻO ka mākaukau hui pū ʻia he kōpala waiū, kahi i hoʻonoho ʻia i nā poʻe maʻi e loaʻa ana i ka nele o ka enzyme lactase, ka loaʻa ʻana o ka galactosemia a me ka glucose a me ka galactose intolerance syndrome.

I ka wā mua o ka mālama ʻana me kahi mākia hypotensive, he hoʻohaʻahaʻa i ke kaomi a me ke kū ʻana o ka dizziness hiki, e hoʻonāukiuki i ka hana psychophysical o ke kino. No laila, nā mea maʻi e pili ana i ka hana me ka nui o ka mālama ʻana i ka wā e hoʻokuke ana i nā kaʻa kaʻa a i ʻole hoʻi i nā ʻenehana paʻakikī e hoʻoholo i ko lākou kūlana ma mua o ka hoʻomau ʻana me kā lākou hana.

JSC Krka, dd, Novo mesto he mea hana i ka lāʻau anti-hypertensive o Lorista (nā papa). Kēia huahana o kēia mea hana i kā lākou hui me ka mea hoʻomehana losartan potassium. No nā ʻano hui like, loaʻa nā lāʻau lapaʻau like ʻelua me nā ʻano hana: losartan potassium a me hydrochlorothiazide.

No Lorista, like ka analoge i nā hopena antihypertensive like a me nā hopena like. ʻO kekahi lāʻau lapaʻau ʻo ia ka lāʻau lapaʻau Kozaar, nā papa o 50 a 100 mg paha o ka potassium losertan. ʻO ka mea hana, ʻo Merck Sharp & Dome B.V. Campaign, ka Netherlands.

No nā mea i hui pū ʻia, ʻo nā mea hoʻohālike ʻo Gizaar a me Gizaar forte. ʻO ka mea hana, ʻo Merck Sharp a ʻo Dome B.V., ka Netherlands. Hoʻopili ʻia nā papa liʻiliʻi liʻiliʻi me ka pā melemele, oval, me ka hōʻailona "717" ma kekahi ʻaoʻao a me ka hōʻailona no ka hoʻokaʻawale ma ka ʻaoʻao ʻē aʻe, a ʻo nā pākuʻi oval papa nui e pākuʻi ʻia me kahi kālena kiʻi keʻokeʻo me ka ʻatikala "745" ma ka ʻaoʻao hoʻokahi.

ʻO ka huiʻana o ka lāʻau lapaʻau "Gizaar Forte" pili i ka potassium losartan ma kahi nui o 100 mg a me hydrochlorothiazide, aia ka 12,5 mg. ʻO ka hui pūʻana o ka lāʻau "Gizaar" e pili ana i ka potassium losartan ma kahi nui o 50 mg a me ka hydrochlorothiazide, aia ka 12,5 mg.

ʻAʻole i like me ia ka lāʻau "Lorista ND", ka lāʻau lapaʻau "Gizaar forte" i ʻelua mau manawa ka nui o ka hydrochlorothiazide, a me nā kiko o ka pākaʻi losertan coincides. ʻO nā lāʻau ʻelua i ka hopena antihypertensive me kahi hopena diuretic iki.

ʻO kekahi mea hoʻohui pilikino ʻo ka lāʻau lapaʻau ʻo "Lozap plus" i hana ʻia e "Zentiva A.S.", Czech Republic. Loaʻa ia i ke ʻano o nā papa elongated me ka pākuʻi ma nā ʻaoʻao ʻelua i kāwele ʻia me kahi kiʻi melemele kukui. ʻO ka hoʻonohonohoʻana o ka lāʻau lapaʻau ka potoma losartan ma loko o kahi nui o 50 mg a me ka hydrochlorothiazide, nā mea he 12,5 mg.

Ke ʻano lāʻau like ʻole no Lorista N ʻo ka lāʻau lapaʻau ʻo Vazotens N, i hana ʻia e Actavis Group a.o., Iceland. Loaʻa i nāʻaoʻao ʻelua. ʻO nā papa papa ʻaina haʻahaʻa he 50 mg o losartan potassium a me 12,5 mg o ka hydrochlorothiazide, aʻo nā papa papaʻa kiʻekiʻe e loaʻa ana he 100 mg o ka pāhare losartan a me 25 mg o ka hydrochlorothiazide.

hypertension arterial (i nā poʻe maʻi e hōʻike ʻia ana ka hui ʻoihana),

ʻO ka hōʻemi ʻana i ka hopena o ka morbidity cardiovascular a me ka make ma ka poʻe maʻi me ka hypertension arterial a waiho aku i ka ventricular hypertrophy.

ʻO nā lāʻau lapaʻau o ka lāʻau Lorista N

ʻO Lorista® N - kahi lāʻau lapaʻau hoʻohui, loaʻa kahi hopena hypotensive.

Losartan. ʻO ka antagonist e pili ana i ka angiotensin II (type AT1) no ka hoʻokūkū waha, ʻaʻohe ʻano o ka protein. In vivo and in vitro, losartan and its biologically active carboxy metabolite (EXP-3174) ālai i nā hopena koʻikoʻi o ka physiologically nui o ka angiotensin II ma luna o ka AT1.

Hoʻololi ʻo Losartan i ka hana ʻana i nā mea hoʻoponopono o ka AT2 ma o ka hoʻonui ʻana i ka pae o ka angiotensin II.

ʻAʻole ʻo Losartan i kāohi i ka hana o ka kininase II, he enzyme e pili ana i ka metabolism o ka bradykinin.

Hoʻēmi i ka OPSS, ka hoʻokaumaha ʻia i ke kahe ʻo ka "liʻiliʻi" o ke kahe o ke koko, e hōʻemi ana ma hope o ke kaumaha, he hopena diuretic.

Kūleʻa ʻia me ka hoʻomohala ʻana o ka hypertrophy myocardial, hoʻonui i ka hoʻolahalaha ʻana i nā maʻi me nā maʻi ʻoi ʻole ka maʻi. ʻO ka lawe ʻana i ka losartan i kahi lā e alakaʻi i ka emi ʻana o ka helu nui ma SBP a me DBP. Ka ʻoluʻolu i ka wailele o Losartan ma ke ao, aʻo ka hopena antihypertensive e pili i ka ʻenikani circadian kūlohelohe.ʻO ka emi ʻana o ke koko i ka hopena o ka hopena o ka lāʻau lapaʻau ma kahi o 70-80% o ka hopena i ka hopena o ka lāʻau, 5-6 mau hola ma hope o ke lawelawe ʻana. ʻAʻole mālama ʻia ka maʻi kahalike, a ʻaʻohe o ka losartan i ka hopena koʻikoʻi ma o ka puʻuwai puʻuwai.

Maikaʻi ʻo Losartan i nā kāne a me nā wahine, ʻoiai ʻo ia i nā ʻelemakule (ma mua o 65 mau makahiki) a me nā mea maʻi (ma lalo o 65 mau makahiki).

ʻO ka hole waiwai. A diuretic thiazide, ka hopena diuretic e pili ana me ka reabsorption impaired o ka sodium, chlorine, potassium, magnesium, wai i loko o ka nealron mamao, nā mea hoʻokaʻawale i nā excretion o nā ions calcium, uric acid. He mau waiwai antihypertensive. ʻAʻohe hopena i kahi kahe koko maʻamau.

Hoʻolaha ka hopena diuretic ma hope o nā hola 1-2, hiki i ka lōʻihi ma hope o 4 mau hola a lōʻihi i ka hola 612

Hoʻohana ʻia ka lāʻau lapaʻau Lorista N i ka wā hāpai

ʻAʻohe ʻikepili i ka hoʻohana ʻana i ka losartan i ka wā hāpai.

Hoʻomoe ka hana a me ka pūpili o ka pūpū, i hilinaʻi i ka hoʻokumu ʻana o ka ʻōnaehana renin-angiotensin, e hoʻomaka i ka hana ma ke kolu o ka hapā o ka hapai. Hoʻonui ka hakakā i ka pūpū me losartan i loko o ka lua a me ke kolu o ka trimesters. Ke hoʻoholo nei ka hapai, pono e hoʻokuʻu koke i ka lāʻau ʻo Lorista® N.

Inā pono, ʻo ke koho ʻana o ka lāʻau i ka wā lactation, pono ia e pani i ka hōʻuluʻulu.