Torvacard "a" Atorvastatin "

Ua hoʻohana maikaʻi kā mākou poʻe heluhelu iā Aterol e hoʻohaʻahaʻa i ka cholesterol. Ke ʻike nei i ka kaulana o kēia huahana, ua hoʻoholo mākou e hāʻawi iā i kou makemake.

ʻO Torvacard ka lāʻau lapaʻau statin. E like me ke ʻano ikaika, loaʻa i ka lāʻau Torvacard nā Atorvastatin, he hopena e hoʻemi ana i ka cholesterol. ʻO ka lāʻau ke hōʻili ʻia e ka hui ʻo Czech "Zentiva" ma ke ʻano o nā papa he 10, 20 a me 40 mg. Hoʻopili maikaʻiʻo Atorvastatin i ka pae o nā lipoproteins a me ka cholesterol i ka plasma koko.

• Nā Hōʻike
• Kino no ka kiʻekiʻe Cholesterol
• Nā rula no ka kuhikuhi ʻana i kahi lāʻau lapaʻau
• I ka hea ʻoe e ʻole e hoʻohana ai iā Torvacard?
• Thorvacard i ka wā hāpai a me ka lactation
• Pehea e lawe ai iā Torvacard?
• Kūlike pili ʻōiwi
• ʻO kekahi mau hōʻailona no ka mālama statin
• ʻO Torvacard analogues a me ke kumukūʻai o nā lāʻau

1. E kūʻē i ke kūmole o kahi meaʻai hypocholesterol me ka hoʻonui nui ʻana i ka hoʻonui ʻana i ka cholesterol, kāwili ʻia ʻo hypercholesterolemia.
2. Me ka piʻi nui o nā waihona serum o ka triglycerides a me dibetalipoproteinemia.
3. ʻO nā maʻi maʻi a me ka puʻuwai ma nā maʻi me ka hopena kiʻekiʻe o ka hoʻomohala ʻana i ka hoʻopiʻi ischemic - ʻoi aku ka makahiki ma hope o 55 makahiki, nā maʻi endocrine, nā maʻi maʻi peripheral.
4. I ka pale ʻana o nā hoʻopiʻi kūmole ma hope o nā kūlana ischemic ʻoiaʻiʻo.

Atorvastatin

He lāʻau statin ka lāʻau lapaʻau a ke kuhikuhi ʻia nei hoʻohaʻahaʻa i ka cholesterol. ^ E Ha yM. I kūʻai aku i nā lāʻau lapaʻau i ka papa ʻaina. Aia ka mea pono e pili ana i ka māhele ikaika atorvastatin i ka nui o 10 a 20 paha i kēlā me kēia papa pākau. Eia kekahi, aia nā mea kōkua o ka magnesium stearate, opadra, starch, cellulose, calcium carbonate a lactose.

Hōʻike ʻia ka hāmeʻa no nā kūlana pili i kēia:

• E hoʻemi i ke kolamu koko.
• I ka hihia ke kōkua ʻole ka mālama ʻana i ka meaʻai.
• No ka mālamaʻana i ka hui pū ʻana me nā lāʻau lapaʻau.

Nui nā helu contraindications ke hiki ʻole iā ʻoe ke lawe i kēia lāʻau lapaʻau. I waena o lākou:

1. Na keiki malalo o na makahiki 18.
2. ʻŌpū a me ka umauma.
3. ʻO nā wahine ʻaʻole i lawe i nā kīpē mana hānau i ka wā hānau.
4. ʻO ke ala paʻakikī o ka nui a me nā pūpū.
5. Lactase nele.
6. Hōʻailona i nā mea.

Me ka mālama nui loa, kauka nā kauka i ka lāʻau lapaʻau no ka hana ʻoi loa ma ka hōʻola ʻana, no ka hōʻeha ʻana, no ka ʻeha, ka maʻi epilepsy, ka maʻi diabetes mellitus a me kekahi mau maʻi o ka thyroid.

Hoʻomaopopo kekahi o nā mea maʻi i ka nānā ʻana o nā hopena o ka hopena. E pili ana kēia:

• ʻO ka loaʻa kālā.
• Hoʻopilikia ʻana i ka gout.
• Allergic hopena pili.
• Hypoglycemia.
• Hoʻemi i ka makemake moekolohe, paʻa ʻole.
• Kūpono.
• ʻO nā maʻi o ka ʻā a me nā hui.
• Nā uhi momona.
• Kūpono paila.
• Hōʻeha ka maʻi hōʻeha, ka ʻeha o ka puʻuwai, ka puʻuwai, ka ʻōpū.
• Anemia
• Nā kipi ʻana o ka hoʻāʻo.
• Pahu a me ka luhi.

Hoʻomaopopo nā kauka i nā mea a nā hopena hopena, aia ke hoʻonui ʻana i ka hoʻoikaika, no laila ke hōʻemi nei lākou i ka dosage, a i ʻole kuhikuhi i nā ʻano lāʻau lapaʻau ʻē aʻe.

Hoʻokuʻu ʻia ka lāʻau lapaʻau e ka lāʻau lapaʻau. ʻO ke kumukūʻai o nā kumukūʻai i aneane 150 rubles no ka paona o 10 mg.

He aha ka ʻokoʻa ma waena o nā lāʻau lapaʻau

Ke huli nei nā lāʻau lapaʻau e mālama ai i nā pilikia like, he like pū ka mea hoʻoikaika. Eia naʻe, kūʻai ʻia ka atorvastatin i ke ʻano he 10 a 20 mg no kēlā me kēia papa pā, a hiki ke loaʻa i Torvacard ma ke kūʻai ʻana ma 10, 20 a 40 mg paha.

ʻOkoʻa ka uku kālā. ʻOi aku ka uku o Torvacard, ma kahi o 300 mau rubles no ka 10 mg. ʻOiʻo Atorvastatin ka liʻiliʻi - e pili ana i ka 150 mau rubles no ka nui like.

ʻOi aku ka maikaʻi e koho

Kūkū pinepine nā kauka i kekahi lāʻau lapaʻau e pili ana i ka ʻike pilikino.Inā loaʻa ʻole i kahi hopena maikaʻi o kekahi ma ke lawe ʻana i kekahi a i ʻole ka hoʻōla, a laila ʻaʻole ia i kuhikuhi hou ʻia.

Ma ka laulā, ua like nā mea ʻelua i nā hana a i nā mea ikaika, no laila ʻaʻole heʻokoʻa loa e kūʻai aku ai, ʻaʻohe. ^ E Ha yM. ʻO ka manawa pinepine, ua alakaʻi ʻia nā maʻi e ka loaʻa ʻana o ka lāʻau lapaʻau i ka manawa i ka manawa. Inā ʻaʻole ʻole kekahi o lākou, a laila hiki iā ʻoe ke kahuli iā ia me kekahi. Eia naʻe, inā makemake kekahi e hoʻololi i nā lāʻau lapaʻau i ka wā o ka mālama ʻana, no laila pono e kamaʻilio i kauka.

Atoris: wehewehe, hoʻohui, noi

Hāʻawi nā ʻoihana Pharmacological i nā lāʻau lapaʻau he nui e hakakā i ka atherosclerosis a me ke kolamu kiʻekiʻe. Pehea e koho ai i ka mea e pono ai a palekana.

He mea kaulana loa ʻo Atoris, kahi lāʻau hoʻohaʻahaʻa i ka cholesterol i ke kino. ʻO ia no ka hui o statins. ʻO ka mea hoʻonaninani ke atorvastatin. Mālama i ka synthesis o ka cholesterol ma o ka pale ʻana i ka hoʻoneʻe ʻana o ka enzyme HMG CoA, hoʻāla i ka hoʻemi ʻana i kona pae i loko o ke koko. Ke hoʻohaʻahaʻa nei ia i ka nui o nā lipoproteins haʻahaʻa haʻahaʻa o LDL kolamu e hoʻopōʻino i nā kānaka, a ʻoi aku, e hoʻonui nei i ka kao ʻana o HDL, e hoʻoulu i kona anti-atherosclerosis. ʻO ka lāʻau lapaʻau ʻo Atorvastatin ka mea i hōʻemi i ka hoʻoneʻe ʻana o nā mea e hana ai i kahi mālama o ke kiko adipose ma ke kino.

No nā poʻe nona nā loina o ka hanauna 3, ʻo ia hoʻi ke kūleʻa loa.

Loaʻa i nā papa o 10, 20, 30, 60 a me 80 ml e ka pūʻulu lāʻau lapaʻau Slovenian o KRKA.
Paipai ʻo Atoris i ka hoʻohana ʻana o nā mea maʻi me ka atherosclerosis a me nā poʻe maʻi me ka kiʻekiʻe o ka cholesterol i ke koko.

I ka wā mua, ua hana ʻia ka lāʻau lapaʻau ma ke ʻano he analogue e pili ana i ka huahana Liprimar ka nui a me ka noiʻi nui ʻia e ka Kelemania ʻo Pfizer. Akā, mahalo i ka hana kūleʻa, ua noho i ka niche ma waena o ka hoʻolālā pharmacological hana o nā statins.

Nā Hana Kūloko ʻOihana Kūlike

Loaʻa nā loli āpau i ka atorvastatin ma ke ʻano nui.

• Liprimar - Pfizer, Kelemānia.

Hoʻokahi i nā hoʻokolohua hoʻokolohua. Ua hōʻoia ʻo ia iā ia iho he mea palekana a pono hoʻi. He kumukūʻai kiʻekiʻe.

• Torvacard - Zentiva, Slovenia.

Hoʻohālikelike i ka poʻe Atoris. ʻO nā mea maʻi ma nā maʻi ma Rūsia.

• Atorvastatin - ZAO Biocom, Alsi Pharma, Vertex - nā mea hana a Lūkia a pau. A kaulana loa ka lāʻau lapaʻau ma Rusia ma muli o ke kumu kūʻai.

Manaʻo nā mea maʻi he nui: Atoris a Atorvastatin, ʻoi aku ka maikaʻi? ʻAʻole maopopo ka pane i kēia nīnau. ʻO ka hui pū ʻana o nā lāʻau ʻelua ke ʻano like. Hoʻolālā kēia i kā lākou mau hana. ʻO ka ʻokoʻa ma waena o lākou i ka ʻoihana a me ka ʻāina o ka hana.

• Atomax - Nā Pūnaewele ʻo Hetero i kaupalena ʻia, India. ʻOkoʻa ka mea e kū ai i Atoris ma ke alo o nā haʻahaʻa haʻahaʻa loa o 10-20 mg. Hoʻomaopopo ʻia no ka pale ʻana i ka atherosclerosis i nā poʻe maʻi maʻi.
• Ator - CJSC Vector, Lūkia.

Kahi ʻia ma hoʻokahi wale nō dosis - 20 mg. Manaʻo ia e hoʻohana i nā papa he nui e loaʻa ai ka nui i koi ʻia.

Nā huahana me nā mea hana ikaika

Kahi pū kekahi o nā lāʻau lapaʻau.

Livazo - Pierre Fabre Recordati, Palani, Italia.

Crestor - Lūkia, Pelekane Nui, Kelemania.

Simgal - Czech Republic, Israel.

Simvastatin - Serbia, Lūkia.

Akā pono e hoʻomanaʻo a ʻo ka simvastatin ka lāʻau lapaʻau mua ma mua.

Nā ʻatikala i hāʻawi ʻia e Filzor.ru

No ka hoʻēmi ʻana i ka pae o ka neʻe a mālama i nā kuhikuhi o nā lipids, kolamu a me ka triglycerides i ke koko, e kuhikuhi i nā lāʻau lapaʻau e pili ana i ka māhele o statins. ʻO kahi hiʻohiʻona nani ʻo Atoris a me Atorvastatin. ʻO nā lāʻau ʻelua ke ʻano like ʻole o ka pūnao, ka hoʻokuʻu ʻana o ka papa papa. ʻO kā lākou hopena therapeutic e like like. ʻO ka weheʻokoʻa wale nō i nā ʻoihana lapaʻau a me nā kumukūʻai.

ʻO ke kauka hele wale nō e hiki ke hoʻoholo i ka lāʻau lapaʻau ka maikaʻi a me ka maikaʻi hou no ka mea maʻi - Atoris a i Atorvastatin.

Hoʻohui pepa puka me nā puka - nā ʻoniʻoni ʻoniʻoni kiʻi.ʻO ka papa hana nui a atorvastatin. ʻO kahi pahu kalana he 10, 20, 30, 40, 60 a me 80 mg o kēia ʻano. ʻO ka māka pili iā 10, 30, 60 a me 90 mau ʻāpana.

Hoʻomaʻa ʻia ka lāʻau lapaʻau i ka hana ʻana o ka cholesterol ma muli o ke kāpili ʻana o ka enzyme e hōʻemi ana i kona neʻe ʻana i ka plasma koko. ʻO ka pae o ka lipoproteins e hoʻopōʻino i ke kino, ma muli o ka hopena o ka hana ikaika ma luna o ka LDL receptors. I kēia hihia, ma ka lūlū ʻana, he nui ka piʻi ʻana o ka lipoproteins density kiʻekiʻe (HDL), e hoʻoulu ana i ka hopena anti-atherosclerotic. Kōkua ka lāʻau lapaʻau e hōʻemi i ka nui o nā mea hoʻohui i hoʻokumu ai i kahi mālama momona.

Nā hōʻailona no ka hoʻohana ʻana:

• hyperlipidemia mua,
• hipololeka,
• paulakowalik
• ka pale ʻana o nā maʻi o ka puʻuwai a me ke koko, no ka poʻe hiki i ka hopena (mai 55 mau makahiki aku, ka hele ʻana o ka maʻi mellitus, ke koko kiʻekiʻe, nā hana ʻokiʻoki, nā predisposition genetic).
• ka pale ʻana o nā hoʻopiʻi o nā pilikia no ka naʻau a me nā kīʻaha koko, me ka maʻa, hōʻeha ka naʻau, ka angina pectoris a me nā mea ʻē aʻe.

Hoʻohana ʻia nā papa e hoʻohana ʻia ma mua o ka ʻai a ma hope paha. I ka mua 10 mg i kuhikuhi ʻia, akā laila hiki ke hoʻonui ʻia ka nui ma 80 mg. Aia ma muli o ka hopena o ka mālamaʻana. Ke nānā nei nā loli maikaʻi ma hope o 2 mau pule o ka hoʻohana pono ʻana i ka lāʻau.

Nā koho hoʻohua:

• māliʻikaʻi kūloko
• hauʻoli maʻa ka ate,
• uhaiki pohihihi
• maʻi pūpū ma ka maʻi kaulike (ʻoi paha no ka hepatitis o nā ʻano etiology),
• lactase kakō, individu lactose intolerance,
• hoʻonui i ka hōʻoluʻolu o kēlā me kēia lāʻau i nā lāʻau a me nā mea pono.

No nā keiki i lalo o nā makahiki he 18, a me nā wahine i ka wā o ka hāpai a me ka umauma, ʻaʻole kūpono ka huahana. Me ka makaʻala, pono e lawe ʻia no ka waiʻona maʻi kūloko, hōʻemi iki nā electrolyte koʻikoʻi, nā ala o nā system endocrine a me nā metabolism, nā maʻi lēʻeha koʻikoʻi, ka maʻi epilepsy, hypotension.

ʻO ka mea maʻamau

ʻO Atorvastatin ka mea hoʻohana nui i nā lāʻau ʻelua, no laila like ka hopena lāʻau lapaʻau. Aia nō ia ma ka ʻōlelo aʻe:

• e hoʻohaʻahaʻa ana i ke koko kolamu,
• ka hoʻoemi ʻana i ka paʻa o nā lipoproteins i ke koko,
• ka hoʻohiolo ʻana o ka ulu nui o nā ʻōnaehana o nā pā o ke kahe o ke koko,
• ka hoʻonui ʻana o ka lumen o nā kahe koko,
• ka hoʻemi ʻana o ke kahe koko, ke kō o nā hana a kekahi mau kuleana i ke kōkiko,
• ka emi ʻana o ka hopena o ka hoʻomohala ʻana i nā hoʻopiʻi e pili ana i ka maʻi coronary.

Hāʻawi ʻia i kēia hopena lāʻau lapaʻau, kuhikuhi ʻia nā statins i nā kānaka i ka wā ʻōpio a i ʻole nā ​​ʻelemakule, a ʻoi aku ka nui i ka poʻe ʻōpio. ʻO nā maʻi no ka hoʻohana ʻana ma Atoris a me Atorvastatin ka aneane like. Hāʻawi ʻia nā lāʻau lapaʻau no nā kumu ʻelua a me nā prophylactic.

ʻO kahi hiʻohiʻona o nā statins ʻelua ka lōʻihi o kā lākou hoʻohana. I nā wā mua, ke kauka nei ke kauka i ka palena iki loa, akā hiki ke hoʻonui ʻia e kaohi koko kolamu. E lōʻihi ka papa, a i kekahi manawa pono nā lāʻau lapaʻau no ka hoʻohana ʻana o ka wā holoʻokoʻa. Ma kēia hihia, kahi hana noiʻi o nā loiloi koko e hana ʻia ana i kēlā me kēia manawa.

ʻO ka hoʻolālā ʻana o nā hopena ʻaoʻao i Atoris a me Atorvastatin e like nō me ka mea hana like. ʻO kēia ka hopena o nā lāʻau lapaʻau i:

• nā aihana o ke kino - nā ʻeha, asthenia, pilikia pilikia, irritability, numbness o nā manamana, pilikia hoʻomanaʻo,
• cardiovascular system - hoʻohaʻahaʻa a hoʻonui paha i ke koko, e hoʻonui ana i ka nui o ka naʻau,
• ʻōnaehana hana - ka hele mai o ka hōʻeha o ka ʻeha ma ka ʻōpū a ma lalo o nā iwi ʻiwa ma ka ʻākau, ka ʻōpū o ka ʻōpū, ka luaʻi ʻana, ka luaʻi ʻana, ka ʻūhā, ka hoʻonui ʻana i ka ʻōhulu, ke koho ʻana a me ka constipation, i kekahi manawa hepatitis, cholecystitis, pancreatitis, ʻeha ʻole.
• urental a me nā ʻōnaehana hana - i ʻole ka maikaʻi ʻole o ka renal, hoʻemi i ka potency, libido,
• musculoskeletal system - ʻeha i nā ʻōpū, nā ʻāpana, nā iwi, nā māiwi,
• hematopoietic ʻōnaehana - thrombocytopenia (i kekahi manawa),
• ʻili - ulupaʻa, ʻeha, peela ma muli o ke ʻano maʻi aloli,
• nā hui kuauhau - hana hoʻoluhi o ka noho ʻana, nā pilikia hoʻolohe.

Inā kū ʻia nā hopena kūpono ʻole ma muli o ka lawe ʻana iā Atoris a i Atorvastatin, a laila pono ke kāpae i ka hoʻohana ʻana i nā lāʻau lapaʻau a hele i ka haukapila. ʻO nā ʻōlelo aʻoaʻo a ke kauka: ʻo ka hoʻemi ʻana o dosage, ka mea me ke aniani a me ka hoʻopau ʻana o nā statins.

ʻOkoʻa ka ʻokoʻa

ʻO ka ʻokoʻa ma waena o Atoris a me Atorvastatin ka pīpī o ka hana ikaika. ʻO ka mea mua he wawaʻe ākea he 10, 20, 30, 40, 60 a me 80 mg, aʻo ka mea hope he 10 a 20 mg wale nō. Me ka hoʻoponopono hoʻoponopono ʻana, eʻoi aku ka maʻalahi o Atoris.

ʻO ka ʻokoʻa ʻelua ka mea hana. Hana ʻia ʻo Atorvastatin e Biocom, Vertex, Alsi Pharma, ʻo ia hoʻi, ʻo nā hui Lūkini. Hana ʻia ʻo Atoris e Krka ma Slovenia.

ʻOi ka uku

Hiki ke kūʻai aku iā Atoris ma Rū ma 400-600 rubles i kēlā me kēia pēpē me 30 papa o ka 10 mg o ka mea nui. Inā ʻoe e koho i ka nui o nā capsules, akā me ka hoʻonaninani o 20 mg, a laila e piʻi ka make a 1000 rubles.

Kuhi ʻia ʻo Atorvastatin-teva ma Rūsia e pili ana i 150 mau rubles no ka pākaʻi me nā papa he 10 mg.

Hōʻike hana

Atorvastatin (Atoris) kahi konohiki koho 3-hydroxy-3-methylglutaryl coenzyme A inhibitor (HMG-CoA), pale i ka hoʻololi ʻana o HMG-CoA i ka mevalonate sterol precursor. ʻO ka lāʻau lapaʻau ka hōʻemi o ka neʻe o ka kolamu ma nā pūpuna o nā puʻuwai, ma muli o ka hopena, ke hōʻike ʻia nei o ka hopena o ka LDL (haʻahaʻa haʻahaʻa lipoprotein receptors - "maikaʻi" kolesterol) hoʻonui ʻia, e hoʻonui ana i ka uptake a me ka catabolism o LDL, a me nā kīpana LDL. Hoʻokomo ʻia ʻo Atorvastatin i kahi emi nui o ka kolamu a me ka kolamu LDL. Eia kekahi, ʻo VLDL cholesterol (haʻahaʻa haʻahaʻa haʻahaʻa lipoproteins), kahi i hōʻemi ʻia ai ka apolipoprotein B a me nā triglycerides. Hoʻopili ke Atorvastatin i ka hopena o nā episode ischemic i loko o nā 16 mau pule ma hope o ka maʻi coronary syndrome, me ka hōʻeha ʻana i nā hoʻopiʻi cardiovascular i nā poʻe maʻi me ka hypertension arterial. 95-99% o ka lāʻau ke kau mai loko mai o ka gastrointestinal tract, kaomi ʻia mai ke kino e nā ʻāpana o ka huaka o ka ʻōpū o ka ʻōpū a me nā ʻāpana. Ma hope o ka lilo mua, ʻo ka bioavailability piha loa e pili ana i ka 12%, ʻo ka hana pale i ke kūʻē i ka HMG-CoA reductase ma kahi o 30% (ma kahi o 70% o kēia hana e pili ana i ka metabolites o Atorvastatin). ʻO ka manawa e hiki ai i ka lōʻihi o ka mālama ʻana he mau hola 1-2. Ma kahi o 98% o ka lāʻau lapaʻau ka mea paʻa i nā protein plasma. Hoʻopili ʻia ka Atorvastatin i ka lapoʻa i nā metabolite ikaika. Ma ka hana o ka lāʻau o ka lāʻau, ʻo ka nui o CYP3A4 e pili ai. ʻO ka hapalua kahi ola he mau hola 14. ʻO ka hopena o ka pale o HMG-CoA e hoʻomau no 20-30 mau hola ma muli o nā metabolite ikaika. Ma kahi o 98% o ka lāʻau lapaʻau ka excreted i loko o ka bile. I nā mea maʻi me ka maʻi ʻakaʻaka puhaka, ua loli nui ka pharmacokinetics o Atorvastatin (e hoʻonui ka nui o ka pae kiʻekiʻe e pili ana i 16 mau manawa, a me ke ʻano ma lalo o ka pāhi e 11 mau manawa). Hoʻomaʻamaʻa ʻia ka emi ʻana o ka pae kolamu serum ma kahi o 2 mau pule ma hope o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa ʻana, a me ka hopena nui e kū mai ma hope o nā hebedoma 4-6 a mālama ʻia i ka wā o ka mālama ʻana. A pau ke hoʻohana ʻana i ka lāʻau lapaʻau, hoʻi ka pae kolamu i ka maʻamau.

ʻo ka mea e ʻoi aku ai ka lypimar a i ʻole torvakard

I ka ʻāpana maʻi, Nā lāʻau lapaʻau i ka nīnau ʻOi aku ka maikaʻi o LIPRIMAR ma mua o TORVACARD? ʻO ka pane maikaʻi loa i hāʻawi ʻia e ka mea kākau ʻo Ignat, ʻo ia ka lypimar iʻoi aku ka ʻoi aku ma mua o ka torvacard.

ʻike maikaʻi ʻia nā ʻelele o ka mea hana pulu me nā kauka, no laila ke kuhikuhi nei lākou i ka ʻoi aku ke keu aku. lawe iā torvakard - ʻaʻohe mea maikaʻi ʻole

ʻO ke kumu ke kauka nona iho

Hana ʻo Torvakard iā Zentiva - ʻo ia kā mākou mau ʻāina mua, a ʻo Lypimar he ʻoihana Belgian me nā hale hana i ʻAmelika a me Tureke, a me nā mea like i loko o kēia mau hoʻomākaukau ʻana nā like - atorvastatin. Mai hoʻopunipuni i kou poʻo. kōkua ʻo Torvakard iā ʻoe ?? ina mai, a inu olua. a no ka mea inu - inā e inu ʻoe i kēlā me kēia lā, no laila ʻaʻole pono ka hōʻike. hiki iā ʻoe ke inu, akā, ʻaʻole i loko o ka lita, a he haneli haneli huamona ʻaʻole e hōʻeha, a ʻaʻole i kēlā me kēia lā

Nā ʻōkuhi no ka hoʻohana o nā lāʻau lapaʻau

Hāʻawi ʻia i ka ʻoiaʻiʻo e pili ana ka atherosclerosis, he mea kūpono ia e hoʻokokoke me ke kuleana me ka kuleana. He paʻiʻo statine ke gula no ka maʻi.

ʻO ka hana o kā lākou hana ka mea like no ka hui holoʻokoʻa a paʻa i ka blockade o nā enzymes redmase HMG-CoA e kāpae i ka kolamu ma ka puʻuwai.

Ke hoʻohana pinepine nei i nā lāʻau lapaʻau, hoʻoponopono nā maʻi i ka hoʻohālikelike o nā hua lipid, me ka pale ʻana i ka kolamu, nā haʻahaʻa-haʻahaʻa iho, triglycerides a me Alipoprotein B. ʻO kēia mau lāʻau lapaʻau ka hōʻemi o ka hōʻeha o ka hōʻeha hōʻeha e like me ka embolism, ka huina myocardial infarction, gangrene of the extremities, ischemic uʻi a me ka angina pectoris, ka manawa mua loa.

Hoʻohana ʻia ʻo Atorvastatin a me nā statins no ka hoʻohana waha. Lawe ʻia lākou me ke kauka a ke kauka kauka, ka mea e aʻo maikaʻi i ka ʻōlelo lipid ma mua o ke kuhikuhi ʻana, ʻōlelo ma ke ʻano o ke ola ʻana a me ka hoʻoponopono ʻana i nā meaʻai, no ka mea, ua ʻoi ke kaumaha i ka hopena o ka lāʻau lapaʻau ma ka kolamu.

A koho ʻia ke kinapo no ka hōʻoluʻolu nui loa o ka mea maʻi a i ka papa hoʻokahi, i lawe ʻia i kēlā me kēia manawa o ka lā, ʻaʻohe mea o ka ʻai. Pono e hana i nā hoʻokolohua hoʻomalu i hoʻokahi manawa i ka malama, no ka hiki ʻole o kahi hopena therapeutic, hoʻoponopono ʻia ke ʻano.

I nā hihia he'ōpiopio koʻikoʻi, hoʻonui ka nui i ka papa he ʻehā i kēlā me kēia lā. I nā poʻe maʻi ʻelemakule, ʻaʻole i hoʻoponopono ʻia ka lāʻau liʻiliʻi liʻiliʻi i hāʻawi ʻia, ma muli o ka hopena o ka hana ʻole o ka renal. No nā kamaliʻi, ʻaʻole pono ka nui o ka dosis i ka iwakālua milligrams i kēlā me kēia lā. ʻO nā maʻi me ka maʻi ate, ua contraindicated ka lāʻau lapaʻau.

Hiki paha ke ulu ʻia o nā hopena maikaʻiʻole, e like me:

• Hōʻeha ka hōʻano, ke hiamoe ʻole.
• ʻO ka ʻeha ʻōpū, nā puʻupuʻu.
• ʻO ka ʻoliu, ka luaʻi ʻawaʻawa, ka ʻawaʻawa i ka waha, lemaki, ʻaʻai a i ʻole constipation.
• ʻO ka ʻeha pena, urticaria.

Ke komo nei i ka ʻōpū, hoʻāwīwī koke ka papa ma ke komo ʻana i ke koko ma o ka membrane me ka palalolo ʻana i kahi o nā kuhi. ʻO Bioavailability o 12%, hoʻopiʻi ʻia e ka pepē, ka hoʻopau ʻana hapa hapa-ola e like me 15 hola.

Hoʻomaka pinepine nā poʻe maʻi i ke kūʻai ʻana mai i ka lāʻau, no ka mea he nui nā kumukūʻai no nā lāʻau lapaʻau, nui ka nui o nā ʻāina e hana ana, ka nui o nā inoa kālepa a loaʻa ka hoʻolaha hoʻolaha ma ka Pūnaewele a me nā televise.

Ke hoʻohālikelike nei kēia i nā nīnau, he aha ka ʻokoʻa ma waena o ka nui o kēia mau lāʻau.

Kino no ka kiʻekiʻe Cholesterol

I ka wā e hoʻohana ai ʻo Torvacard, hōʻike ka poʻe loea i ka nānā ʻana i kahi meaʻai kūikawā, ke alakaʻi nei i ka hoʻohaʻahaʻa i ka cholesterol. ʻO nā lula nui o ka meaʻai kolamu:

• kaupalena paakai loa
• ua māhele ʻia ka meaʻai i kēlā me kēia lā i ka ʻahaʻaina 5-6,
• ka palena a i ʻole hoʻokaʻawale ʻana i nā momona holoholona,
• ʻae ʻole ka hana ʻana, ka lawena, ka kuke ʻana, ka kuke ʻana i ka paila.
• hana ʻia o ka kuke ʻana me ka kuke ʻana, ka ʻaʻapa ʻole me ka hoʻohana ʻole o ka aila, ka aʻa ʻana,
• pono ka ʻai me ka ʻai, nā hua, nā kō,
• pono ʻoe e kaupalena i ka hoʻohana ʻana o ka hua, ka pata,
• pono e hoʻokaʻawale i ka sausage, ka uū i ka pipi, sausages, nā huahana semi-paʻa, nā meaʻai paʻa, nā huahana momona momona.

ʻAʻole pono nā mea ʻai i nā mea ʻelua 2700 i kēlā me kēia lā. ʻO ka hoʻokō ʻana me nā rula kai e hiki ai iā ʻoe ke hoʻokolohua a kūleʻa i nā kolamu a pale aku i nā hoʻopiʻi vascular.Inā lawa ʻole ka lāʻauʻai e hoʻohaʻahaʻa i ka cholesterol, ua kuhikuhi ʻia nā statins.

Nā rula no ka kuhikuhi ʻana i kahi lāʻau lapaʻau

Inā hoʻoholo ʻia ka mālama ʻana no ka manawa mua, pono e koho i ke ʻano kūpono o ka lāʻau. ʻO ka maʻamau, hoʻomaka ka mālama ʻana i ka hypocholesterolemia ma ka liʻiliʻi liʻiliʻi o 5 a 10 mg o ka atorvastatin.

Ma hope o 3 mau hebedoma e mālama ai me nā statins, nā moʻiole a me nā ʻāpana kaulike e nānā.

Inā ʻaʻole i loli iki ka pae kolamu a emi iki paha, ua hoʻonui ʻia ka nui o ka lāʻau. I kēia hihia, pono e uku ʻia i nā ʻōkuhi pili ʻana o ka ate.

I ka hea ʻoe e ʻole e hoʻohana ai iā Torvacard?

E like me nā lāʻau olin statin, he loaʻa nā Torvacard i ka hoʻohana ʻana:

1. Ke hoʻomanawanui ʻole i kekahi o nā mea kōkua a i ʻole ka hana ikaika.
2. ʻO nā maʻi ʻeha o nā ʻano kumu like ʻole i ka hana ikaika.
3. ʻO ka hoʻonui ʻana i ke pae o ka huina o nā enzyme o ka ʻike ʻole ʻia ma mua o ʻekolu.
4. ʻO nā makahiki o ke kula ʻana i nā wahine i hoʻohana ʻole i nā hana kūlau pono.
5. He 18 makahiki.

ʻO nā contraindications ma luna aʻe he kūlike, akā aia kekahi mau maʻi e ʻae ʻia ai ʻo Torvacard, akā me ka makaʻala. I nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana iā Torvacard, ua wehewehe ʻia kēlā mau ʻano.

• haʻahaʻa mau koko
• hana hoʻokūkū koʻikoʻi, ʻoi loa hoʻi ka ʻōpū o ka ʻōpū,
• maʻi maʻamau - sepsis,
• maʻi maʻi ʻōnaehana o ka musculoskeletal
• ka hemahema o ka wai a me nā electrolytes i loko o ke kino,
• maʻi ma loko o nā wā ma mua
• ʻehā a me nā maʻi ʻē aʻe me ka hopu ʻana i ka hoʻomanawanui,
• maʻi mellitus maʻiʻi.

I kēia mau hihia, hoʻomaka ke hoʻohana ʻana i nā papa ʻo Torvacard me nā hōʻemi haʻahaʻa a hoʻonui i ka nui o ka dosis e nānā pono ana, e nānā ana i ke ʻano o ka mea maʻi.

Thorvacard i ka wā hāpai a me ka lactation

Inā hele mai ka hapai i ka wā e lawe ana i ka Atorvastatin, mālama ʻia ka lāʻau me ka lāʻau lapaʻau. Ua hōʻike ʻia nā noiʻi holoholona holoholona i hiki i ka lāʻau lapaʻau ke loaʻa ka hopena hona i ka kuʻi. ʻAʻole i lawelawe ʻia nā haʻawina o nā hopena o ka atorvastatin e pili ana i nā kānaka i ka wā hāpai. Eia kekahi, i ka wā o ka umauma, ʻaʻole i hoʻohana ʻia ʻo Torvacard, no ka mea ʻaʻohe data e hiki ke hoʻopaʻa i nā statins e hoʻopaʻa ʻia me ka umauma wai. Inā lawe ka wahine i mau statins ma mua o ka hāpai ʻana, a laila e pono ke hoʻopau ʻia nā kālā no ka wā holoʻokoʻa o ka hānau ʻana a ʻo ka pēpē. ʻO ka Atherosclerosis kahi hana hoʻomehana lohi e hele nei, no laila, ʻaʻohe mea koʻikoʻi e hiki mai ana i ka wā o ka hōʻemi ʻana i ka lāʻau. Ma hope o ka pauʻana o ka lactation, lawe ʻia ka lāʻau Torvacard i ka ʻaiʻana like ma ke kauoha o ke kauka.

Pehea e lawe ai iā Torvacard?

Lawe ʻia ʻo Torvacard i kēlā me kēia manawa - ma ke kakahiaka, i ke ahiahi a i ka pō paha, me ka mālama ʻole i kahi meaʻai. ʻO Torvacard 10 mg ke ʻano mua. I kekahi mau hihia, ʻo ka hapalua o ka pilila e kuhikuhi ʻia me ka ʻōlelo mua. Inā lawa ʻole nā ​​kumu o 10 mg, ma hope o ka mālama ʻana i ke pae o ka cholesterol, Torvacard 20 mg, a ʻo Torvacard 40 mg e kuhikuhi ʻia.

ʻO ka nui o ka lāʻau lapaʻau e pono e wae ʻia e ke kauka ma hope o nā loiloi pono a me nā loiloi. Ke pāpā ʻole ʻia nei e hoʻonui i ke kūʻokoʻa o ka make o ka lāʻau lapaʻau!

ʻO nā hopena ʻino i ka wā e lawe ai ʻo Torvacard mai ka nui o nā kino a me nā ʻōnaehana o ke kino:

1. Ma ka ʻāpana o ka metabolism, ka ʻike ʻana o ka flukue i loko o ke kō koko koko, ke loaʻa ʻana o ka paona, a i ʻole ka momona koʻikoʻi.
2. Pūnaehana wahī: paresthesia, hoʻololi i ka ʻike ʻono, hoʻomanaʻo hoʻomanaʻo, neuropathy.
3. ʻO ka pahuhopu - kūlia ka maʻi mai ka ʻā i ke kino i ka pīhoihoi anaphylactic.
4. ʻO ke koko a me ka ʻōnaehana hematopoietic: kahi hōʻemi o nā pae platelet i loko o ke koko.
5. ʻO nā maʻi noʻonoʻo ma ke ʻano me nā moemoeā a me nā maʻi ʻē aʻe.
6. Hoʻopili i nā ʻōnaehana - nā maʻi dyspeptic i ke ʻano o ka hōʻilo, constipation, ke nānā ʻana, ka ʻōpū, ka ʻōpū, ka ʻeha o ka ʻōpū, ʻawaʻawa.ʻOi paha ka hoʻomohala ʻana o ke kaʻina a me ka maʻi i ka pancreas.
7. Hiki i ka ʻōnaehana musculoskeletal ke pane i ka hoʻohana ʻana i nā statin e ka puka ʻana o ke ʻeha ma nā ʻāʻī, nā ʻāʻī, nā iwi, nā ʻōpū kūpilikiʻi, ka hoʻomohala ʻana i ka myopathy, rhabdomyolysis a me nā pilikia ʻē aʻe o ka ʻōnaehana musculoskeletal. Hoʻomaʻamaʻa ʻia ka mea maʻi i kuhikuhi ʻia i nā statins e pili ana i ka pono ke ʻike i ke kauka inā he ala ākea i loko o nā ʻōpū a me nā iwi.
8. Eia kekahi, i ka wā o ka mālama ʻana me nā statins, hiki i ka hoʻomohala ʻana o ka moe kolohe.

ʻO nā hopena pinepine ʻole i nā hopena a me ke kumu kūpono ʻole. Ma ke ʻano he laʻana, ma hope o ka hoʻoponopono ʻana i kahi maʻa therapeutic, ua emi loa ka ikaika o nā hōʻailona me ka nui, a i ʻole nā ​​hemahema e nalowale loa. Eia nō naʻe, aia nā hopena ʻokoʻa, ka hopena o ka mea e pono koke e kāpae i ka mālama ʻana me Torvacard a huli koke i ke kōkua olakino. ʻO kēlā me kēia mau hopena ka nui o ka ʻehaʻeha a me nā pehu.

Kūlike pili ʻōiwi

Hiki i ka Myopathy ke alakaʻi i ka hana ʻole o ka pilikia ʻole, no laila e ʻōlelo ʻia ka mea maʻi e pono e hoʻokuʻu i ka lāʻau lapaʻau a ʻike koke i kahi kauka i ka ʻeha o ka ʻehaʻeha o ke kino. Pākuʻi allergic koi hou i ka haʻalele koke ʻana i ka lāʻau. Hoʻokomo i kahi alerine i ke ʻano o ka hōʻau a me ka hives a ʻaʻole e hōʻeha i ka pōʻino nui, a ke kaʻi ʻana o ka maka a me ka ʻāʻī e hiki ke alakaʻi i ka bronchospasm a me ka pilikia i ka hanu. ʻO kahi kūlana e hoʻoweliweli koʻikoʻi i ka pīhoihoi anaphylactic. No laila, inā puka mai nā hōʻailona o ke alaka, mai inu i nā papa Torvacard.

Ma ka hihia hoʻokahi o ka nui o ka nui o ka lāʻau a i ʻole ka ʻōnaehana ʻōnaehana ʻōnaehana o ka dosage i ʻōlelo ʻia ʻia, hiki mai ka maʻi make atorvastatin. Ma ke kānāwai, he overdose hōʻike iā ia iho e like me nā hōʻailona o ka maʻi hana ʻana. ʻAʻole i loaʻa ka hopena o ka peni i kēia hihia, no laila ke hōʻailona nei ka mālamaʻana o ka overdose.

ʻO kekahi mau hōʻailona no ka mālama statin

• Ma mua o ka hoʻomaka ʻana i ka mālama ʻana me nā lāʻau lapaʻau e loaʻa ka hopena e hoʻēmi i ka cholesterol, pono e hana i nā kaʻina no ka non-pharmacological hōʻemi o ka pae kolamu: ka hana kino, ke kaumaha, ka hoʻolaʻa ʻana i ka ʻai. A laila, inā ʻaʻole alakaʻi kēia mau kaʻina i ka hopena i makemake ʻia, ua kuhikuhi ʻia nā statins.

• Pono e nānā ʻia nā mākaʻikaʻi o ka hana ʻōiwi ma mua o ka hoʻomaka ʻana o ka mālama ʻana, a ma kēlā me kēia manawa, ma ka liʻiliʻi ʻelua ma ka makahiki a ma hope o kēlā me kēia hoʻonui i ka make o Torvacard.
• Inā nui aʻe nā ʻōkuhi hepatic, pono ka nānā ʻana o ka mea maʻi e kahi kauka a hoʻi lākou i ka maʻamau.
• Pono e mālama pono i ka wā e kuhikuhi ana i ka lāʻau lapaʻau i hui pū ʻia me nā lāʻau ʻē aʻe. Pono e hoʻohana pono ʻia ka hoʻohana ʻana i nā lāʻau lapaʻau ʻē aʻe, no ka mea hiki i ka Atorvastatin ke hiki ke hoʻopili me nā mea lāʻau lapaʻau.
• Ke lawe nei ʻo Torvacard, pono e hoʻomaʻemaʻe ka makaʻala ma ka hana me nā kumu o ka nui o ka pilikia a me ka hoʻokele.

ʻO Torvacard analogues a me ke kumukūʻai o nā lāʻau

I loko o nā lāʻau lapaʻau, he nui nā lāʻau lapaʻau e pili ana i ka Atorvastatin, ʻo ia nā mea kikoʻī o Torvacard. No ka laʻana, ʻo nā mākaukau o ka hui Krka - Atoris, Pfizer - Liprimar he mea kaulana loa i waena o nā kauka. Kūkulu hou nā mea hana hale i Atorvastatin i nā ʻano like ʻole - 10, 20, 30, 40 a me 80 mg. ʻO ke kumukūʻai o Torvakard analogues e hilinaʻi ana i ke kumukūʻai mea kākau inoa inoa, nā hale kūʻai ʻenehana a me nā kūʻai aku hale kūʻai, a me ke kumukūʻai kumukūʻai o kekahi lāʻau kūʻai. Eia nō naʻe, komo nā hoʻomākaukau no Atorvastatin i ka papa inoa o nā lāʻau lapaʻau pono a me nā pono, a no laila e loaʻa nā kumukūʻai marginal ma luna o kahi hiki ʻole ke kumukūʻai. ʻO ke kumukūʻaiʻoi loa o nā kālā i loaʻa Atorvastatin ka lālani Liprimar kūlohelohe, i hana ʻia e ka hui ʻo Pfizer.

I ka manawa o nā lāʻau lapaʻau e pili ana i ka Atorvastatin, i kēia lā ke kānalua nei, no laila ua hoʻohana nui nā statins i nā hana lapaʻau.

ʻOi aku ka ʻoi a me ka palekana

I kēlā me kēia lā, ke piʻi nui nei ka pilikia o nā pathologies a me nā maʻi o ka ʻōnaehana cardiovascular, no ka mea he pilikia maoli nō ia e noho ana i nā wahi mua i waena o nā kumu o ka make ʻana o nā maʻi. ʻO kekahi o nā maʻi alakaʻi a maʻamau loa hoʻi, ʻo ka atherosclerosis. Aʻo ka mea kūpono he statins ka palekana a me ka maikaʻi loa i ka hakakā ʻana i ka hōʻiliʻili ʻana a me ka hoʻokumu ʻana o ka kolamu endogenous.

ʻO keʻano maʻamau

Hoʻokaʻawale ʻia nā māka o kēia hui i nā ʻāpana 2: ka mea kūlohelohe a me ke ʻano, i hana ʻia. A no nā 4 mau hanauna. ʻO ka hanauna mua nā polines kūlohelohe maoli i hūnā ʻia mai nā pulehu. He aha kā lākou mau mea:

1. ʻO ka hanauna mua ka lovastatin, simvastatin. Loaʻa iā lākou ka hopena o ka lāʻau lapaʻau ma mua o nā lāʻau o nā hanauna ʻē aʻe, hiki i nā hopena ʻaoʻao.
2. ʻO ka pōpō ʻelua ka fluvastatin. Hoʻohālikelikeʻia me ka mea hoʻomaha, koi ʻia ka hoʻohana hou aku, akā naʻe, ke ʻano nui o ka paʻa ʻana i ka lāʻau i loko o ke koko.
3. ʻO ka hanauna ʻekolu he atorvastatin. ʻO ka hoʻohaʻahaʻa nui i ka pae o ka triglycerides (THC) a me nā lipoproteins haʻahaʻa haʻahaʻa (LDL) a me ka hoʻonui ʻana i ka lipoproteins kiʻekiʻe-density (HDL) pono no ka kiola o ka cholesterol hewa ʻole.
4. ʻO ka hua ʻehā he rosuvastatin. Hoʻonui nui i ka hana kūpono a me ka palekana, i hoʻohālikelike ʻia me nā koena.

Hoʻohui hou i hoʻokahi hana maʻamau - hōʻemi ʻia ka kolamu, ʻo kēlā me kēia lāʻau lapaʻau ka ʻokoʻa o nā hiʻohiʻona a me nā hopena hou aʻe. ʻO kēia no ke ʻano o ka hanana, a me kekahi kanaka hoʻokahi.

Wehe waiwai

ʻO ka pane i ka nīnau "he aha nā statins i ʻoi aku ka palekana a me ka ʻoi aku?" Ua pili ka poʻokela i ka hoʻopili ʻana o ka cholesterol i ka puʻu, ma o kona kaohi ʻana. Hana kēia ma muli o ke kaita ʻana o ka hoʻoneʻe i komo i ke kāpili o ka kolamu endogenous - HMG-CoA reductase. Ua hōʻiliʻili kēia kaomi i nā mea kanu o ka waiona mevalonic, kahi mea i mua o ka cholesterol. Ma kahi o kāna hopena nui, loaʻa i nā statins kekahi mau ʻē aʻe.

• ka hopena ma ka endothelium vascular, ma o ka hoʻohaʻemi ʻana i ka nahu a me ka hoʻemi ʻana i ka hopena o nā kiʻi koko,
• ka hooulu ana i ka synthesis o nitric oxide, ka mea i kōkua i ka hoʻonui ʻana o nā kīʻaha koko a me kā lākou hoʻomaha.
• kākoʻo ana i ka pehu plg atherosclerotic.

Hoʻopili i nā mea pale a me ka pale ʻana i ka atherosclerosis, he nui nā hopena o nā statins i nā maʻi ʻē aʻe:

1. Kākoʻo o ka myocardial infarction. I ka hoʻohālikelike ʻana me nā lāʻau lapaʻau e pili ana i ka mālama ʻana i kēia maʻi, ua ʻoi aku ka maikaʻi o nā statins. No ka laʻana, hōʻike ʻia nā haʻawina e pili ana i ka hoʻohana ʻana o resuvostatin i ka hōʻemi nui ʻana i ka hopena o ka hoʻoulu ʻana o Myocardial infarction i ka poʻe i lawe iā ia no 2 mau makahiki.
2. Me ka pale ʻana o ka hōʻeha ʻana o ka puʻuwai, hōʻemi nui lākou i ka hiki ke kūpaʻa ischemic.
3. I ka wā o ka hoʻihoʻi ʻana o ka post-infarction, pono nō e hoʻopio ʻia nā statins. Me ka mālama maʻamau, loaʻa lākou kahi hopena maikaʻi loa a ke hoʻokuʻu nei i ke kaʻina hōʻola.

ʻO kahi kikoo nui o ka hana ma ka ʻōnaehana cardiovascular ua hana i ka hui o statins, ka mea i kaulana loa a maikaʻi loa, e hoʻohālikelike ʻia me nā lāʻau lapaʻau ʻē aʻe.

Nā Hoʻohui

Ke koho nei i kekahi lāʻau lapaʻau mai kēia pūʻulu, pono e mālama pono ke kauka, i ka nui o nā nuances. No ka laʻana, pono ke hāʻawi ʻia nā kaikamahine i nā mea hoʻohālikelike i ke koho ʻana i ka mālama ʻana, no ka mea, ʻaʻole e lawe ʻia nā statins e nā wahine hāpai. Inā makemake ka hoʻohana i ka lāʻau lapaʻau e ka wahine hāpai, a laila pono ke mālama i ka manawa, a me nā ʻano āpau āpau.

Ma keʻano holoʻokoʻa, hiki ke hoʻokaʻawale ʻia nā contraindications ma hope:

• nā maʻi āpau, e komo pū ana me ka hoʻomehana
• hapai
• nā maʻi o nā pūpū, ka ʻoihana endocrine, nā lau thyroid.
• nā pilikia i ka ʻōnaehana musculoskeletal,
• nā maʻiʻeha a me nā maʻi paʻa
• maʻi mellitus maʻiʻi.

ʻO nā Contraindications kekahi mea koʻikoʻi i ka hoʻohana ʻana o nā statins. ʻO ka pololei o ka ʻikepili i loaʻa e ka mea maʻi, nā manawa papa, ka manawa o nā maʻi mauʻeha. pili kēia i nā mea kūpono a maikaʻi ʻole paha i ka lawe ʻana i ka lāʻau lapaʻau e nā mea maʻi.

Nā hopena hopena

ʻO nā manawa pinepine, ua lawe ʻia nā statins, me kahi hopena ʻole ʻole, no ka manawa lōʻihi. I loko o nā haʻawina, ua hōʻike ʻia he 3% wale nō o nā kumuhana i loaʻa nā hopena pōʻino, akā ua ala mai i loko o ka poʻe i lawe i nā lāʻau lapaʻau ma mua o 5 mau makahiki.

Aia ka hopena o ka myopathy, akāʻo ka liʻiliʻi (0.1-0.5%). ʻO ka hiki ʻana o nā myocytes (nā mākala o nā ʻōpū ma ke kikoo), ke hilinaʻi pololei nei i ka luhi o ka lāʻau, ʻōpio (nā poʻe i ʻoi aku ma mua o 70-80 mau makahiki i hiki ke ʻeha i nā maʻi o ka māla), nā mea kanu ʻole kūpono ʻole, me nā hoʻopiʻi o ka maʻi diabetes.

Eia kekahi, me ka hopena o ka ʻole iʻoi aku ma mua o 1%, hiki i nā hōʻeha CNS: hōʻehaʻeha, poʻomanaʻo, hoʻomaha a hiamoe, nāwaliwali maʻamau. Ua hōʻike ʻia ka hopena o ka ʻaoʻao o ka pūnao e ka rhinitis, ka ulu ʻana o bronchitis. Ua pane aku ka ʻōnaehana o ka digestive i ke ʻano o ka nausea, hoʻopuka, a me ka constipation. Akā he mea kūpono ʻole e hele ana nā mea āpau o luna ma ka 1% o nā maʻi i loaʻa.

Ma keʻano holoʻokoʻa, mālama pono a ʻoluʻolu ka hāʻawi wale ʻana i kahi hopena maikaʻi, akā inā ʻoe e hoʻohana i nā lāʻau lapaʻau me ka lōʻihi ʻole, a laila hiki mai nā hopena like ʻole:

• ʻeha i loko o ka ʻōpū, ka ʻōpū liʻiliʻi, constipation, vomiting,
• amnesia, insomnia, paresthesia, dizziness,
• kahe ʻana i ka helu platelet (thrombocytopenia),
• huhū, huʻu, hemahema i ka kāne.
• nā māpū o hope, ʻeha ʻeha, arthritis, myopathy.

I ka hui pū ʻana me kekahi mau lāʻau lapaʻau, no ka laʻana, ka hoʻoilo ʻana o lipid, he hopena maikaʻi paha e kū ʻia.

ʻO nā lāʻau palekana maikaʻi loa o ka hui

Ma ka hōʻike ʻana i nā haʻawina he nui, ʻike ka ʻepekema i ka pane i ka nīnau - ʻo wai nā statins i palekana a i ʻoi loa? ʻO ka mea mua, pono ia e hōʻike i ka atorvastatin, ka mea i hoʻohana pinepine ʻia a hōʻike i nā hopena noiʻi maikaʻi loa. Hoʻohana liʻiliʻi ʻo Rosuvastatin. Eia, ʻo ke kolu o nā loea e hoʻokuʻu aku i ka simvastatin, kahi lāʻau lapaʻau hilinaʻi hoʻi.

Rosuvastatin

ʻO Rosuvastatin kahi lāʻau lapaʻau synthetically i hana ʻia i ka pūʻulu statin, ua puʻu ʻia ka hydrophilicity ma muli o kahi i hōʻemi ʻia ai ka hopena ʻāʻā o ka ate, a hoʻonui pū hoʻi i ka hana pono o ka pale ʻana i ka moloproteins low density (LDL). ʻO LDL kahi pilina koʻikoʻi i ka synthesis synthesis. ʻAʻole ke kumu o Rosuvastatin i kahi hopena maikaʻi loa e pili ana i ka ʻoi aku o ke kino, ʻo ia hoʻi, hiki iā ʻoe ke lawe a hopohopo ʻole e pili ana i ka hanana ʻana o ka myopathy a me nā ʻōpū puʻuwai.

ʻO ka hoʻohana ʻana i kahi waihona o 40 mg e hāʻawi i ka emi ʻana o nā pae LDL i 40%, a i ka manawa like, he hoʻonui o ka lipoproteins kiʻekiʻe (HDL - nui ka hoʻemi ʻana i ka hopena o ka atherosclerosis) e ka 10%. ʻOi aku ka maikaʻi o Rosuvastatin ma mua o nā lāʻauʻokoʻa. No ka laʻana, ʻo ka hoʻohana ʻana o kahi pānaʻi o 40 mg he ikaika ikaika ma mua o ka lawe ʻana he 80 mg o ka atorvastatin. Hiki i ka nui o 20 mg ke hoʻemi i ka nui o LDL, e like me 80 mg o ka atorvastatin like.

Hōʻike ʻia ka hopena kūpono i loko o ka hebedoma mua o ka hoʻohana ʻana, a hiki i ka lua o ka pule he 90-95%, a i ka hā o ia hiki i kona kiʻekiʻe a e hoʻomau mau ʻia ia, e pili ana i ka hana maʻamau.

Simvastatin

Wahi a ke aʻo ʻana, ʻo ka lawe ʻana i kēia lāʻau lapaʻau no 5 mau makahiki e hoʻēmi i ka maʻi o nā maʻi vascular a me ka puʻuwai ma ka post-infarction period ma ka 10%, a me ka pae like like me nā poʻe maʻi me ka maʻi cardiovascular, ka maʻi maʻi a me ka hōʻeha.

Ua hōʻike ʻia ma mua o 2 mau makahiki, ua hoʻonui ʻia ke kaila o nā lipoproteins e pili ana i ka synthesis / hoʻohana i ka cholesterol, e hoʻemi ʻia ka nui o nā kihe koko i loko o ka lāʻau coronary.

Ma ka laulā, ua palekana palekana i nā statins i kā lākou hoʻohana. Aia kekahi makehewa nā hopena ʻaoʻao, akā liʻiliʻi iki. Kau ka mea āpau i ka mālama a me ka hoʻomaopopo ʻana o ka mea maʻi. Ke hoʻoili nei i nā hiʻohiʻona pilikino o ka mea maʻi, kona ʻikepili o kona makahiki a me ka hoʻoilina, hiki i ke koho ke ana i ka statin e pono ai e hāʻawi i ka hopena kūpono loa.

Pehea e koho ai i ka lāʻau kūpono?

I nā kaula lāʻau lapaʻau, hiki iā ʻoe ke loaʻa i ʻelua mau lāʻau lapaʻau. ʻO ka mea mua nā mea kumu, nā mua hoʻomohala o nā mea kanu lapaʻau i loaʻa he patent no nā makahiki he iwakālua.

ʻO ke ʻano kēia no kahi hapa o ʻekahi hapaha, ʻo kēia hui wale nō ke hana i kēia lāʻau lapaʻau. A hiki i ka pau ʻana o ka mea make, ʻaʻole hiki ke ʻike ʻia nā mea e neʻe ai ma ka pale. Akā ma ka hopena o kēia manawa, kāpae ʻia ka pale a puka mai nā kope. I kēia hihia, ʻo ke kumu o kahi mea i kauoha ʻia no ka nui o nā mea nui.

No ka hoʻākāka maʻalahi ʻana i ke kumu - no ka hana ʻana i kahi huahana kūʻokoʻa, ua hoʻohana nā ʻepekema i nā piliona kālā o ke kālā he nui o nā hoʻokolohua lōʻihi a hoʻopaʻa ʻia i ka pono a me ka palekana o kekahi helu o nā kumuhana like ʻole. ʻO ke kaʻina he hana ma mua o ʻumi makahiki.

Nā Generics (a i ʻole generics), ʻo ia ka lua o ka hui, ke mākaukau clone hoʻomākaukau me nā hiʻohiʻona like.

I mea e hana ai iā lākou, pono ʻoe e lawe i kahi ʻano i hana ʻia, hoʻohui i nā mea kōkua i ka hoʻopili mua, hele ʻana me kahi inoa hoʻomanaʻo maʻalahi a waiho i ke kūʻai aku.

ʻAʻole like nā like o ka ʻenehana hana like me ka lāʻau lapaʻau mua, no laila he maʻi maʻamau ka kūʻana i ka hana a ke kanaka.

Kūpaʻa ke kumukūʻai i nā kumu he nui: ke kaʻina hana hana, ka hoʻohui ʻana o nā mea hoʻohui hou, ka nui o nā hoʻokolohua lapaʻau i hala. Hiki ke hoʻokaʻawale ʻia ka noiʻi i:

1. ʻO Bioequivalent, ʻo ia hoʻi, ke nānā ʻana no nā pāʻani me ke ʻano laia,
2. Lapaʻau - hōʻoia i ka hana kūpono o ka hana,
3. A me ka therapeutic, e aʻo ana i ka hopena o nā generics ma ke kanaka.

Kūlike pololei ke kumukūʻai i ka helu o nā haʻawina - ʻo ia hoʻi, ʻoi aʻe ka nui, ʻoi aku ka nui o ka huahana.

I ka hui o nā lāʻau lipid-hoʻokuʻu i ka atorvastatin, he kumu. I loko o nā hoʻokolohua lapaʻau e mau ana he ʻumikumamālua mau mahina, hōʻike ʻo ia i kēia hopena:

• ʻO ka hoʻoneʻe ʻana o nā lipoproteins haʻahaʻa haʻahaʻa i hoʻemi ʻia e 55%,
• Holo ka huina o ka kolamu 46%,
• Hāpai ke kiʻekiʻe o ka lipoproteins density kiʻekiʻe (ʻo ia ka "maikaʻi" kolesterol, ʻaʻole ia e clog vessel) e 4%.

ʻO ka maʻa i lawe ʻia e nā mea hana he 10 milligrams i kēlā me kēia lā.

I ka hoʻohālikelike ʻana i nā lāʻau lapaʻau me ka mea i loaʻa i kekahi mau statins e pono i kahi koina kiʻekiʻe e hoʻokō i ka hopena - no ka Torvacard he 20 milligrams, no Simvastatin - 40, a no Fluvastatin ka nui o 80.

ʻAʻole makemake kēia o kēia mau ʻike i nā kope, e hoʻohele i ka ʻokoʻa nui.

Torvacard - nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, nā loiloi, nā hoʻohui a me nā puka hoʻokuʻu (10 mg, 20 mg a me nā papa 40 mg) o ka lāʻau statin e hoʻohaʻahaʻa i ka kolamu a pale i nā maʻi cardiovascular ma nā pākeke, nā keiki a me ka hānau ʻana

I kēiaʻatikala, hiki iā ʻoe ke heluhelu i nā ʻōkuhi no ka hoʻohana ʻana i ka Torvard lāʻau. Hōʻike ʻia nā loiloi o ka poʻe malihini kipa - nā mea hoʻohana o kēia lāʻau lapaʻau, a me nā manaʻo o nā loea lapaʻau e pili ana i ka hoʻohana ʻana iā Torvacard statin i kā lākou hana.ʻO kahi noi nui, ʻo ia ke hoʻoikaika ikaika i kāu mau loiloi e pili ana i ka lāʻau lapaʻau: kōkua ka lāʻau lapaʻau a ʻaʻole hoʻi i kōkua i ka hoʻopiʻi ʻana i ka maʻi, nā mea hoʻopiʻi a me nā hopena ʻaoʻao, ua ʻike ʻia, ʻaʻole paha e hoʻolaha ʻia e ka mea hana ma ka palapala. Nā kikowaena o Torvacard ma ke alo o nā kikowaena hoʻonohonoho ʻona i loaʻa. E hoʻohana i ka hoʻohaʻahaʻa i ka cholesterol a pale i nā maʻi cardiovascular ma ka pākeke, nā keiki, me ka wā hāpai a me ka lactation.

ʻO Torvacard kahi lāʻau lapaʻau hypolipidemic mai ka pūʻulu o nā statins. ʻO ka mea hoʻoneʻeneʻa hoʻokoe koho o HMG-CoA reductase, he enzim e hoʻololi i ka 3-hydroxy-3-methylglutaryl-coenzyme A i ka mevalonic acid, kahi mea i mua i ka steroid, e komo pū kekahi me ka cholesterol. Ma ka ate, ua hoʻokomo ʻia ka triglycerides a me ka kolamu ma VLDL, e komo i ka plasma koko a lawe ʻia i nā kōpili peripheral. Mai VLDL, hoʻokumu ʻia LDL i ka wā o ke kikowaena me nā mea hopu LDL. Atorvastatin (ka hana ikaika o ka lāʻau Torvard) hoʻēmi i ka plasma cholesterol (Ch) a me nā lipoproteins e ka pale ʻana i ka hoʻoneʻe ʻana o HMG-CoA, synthesizing kolesterol i ka ate a hoʻonui i ka nui o nā mea LDL i loko o ka ate i ka pūlima, e alakaʻi ai i ka hoʻonui nui a me ka catabolism o LDL . ^ E Ha yM.

Hoʻopili ʻo Atorvastatin i ka hoʻokumu ʻana o LDL, e hoʻoiho i ka nui o ka hoʻonui a hoʻomau ʻia i ka hana o nā mea LDL. ʻO Torvacard e hoʻohaʻahaʻa i nā pae o ka LDL i nā mea maʻi me ka hypercholesterolemia homozygous homozygous, ʻo ka mea maʻamau ʻaʻole ia e mahalo ʻia e ka maʻi me nā mea maʻi hypolipidemic.

E hōʻemi ana i ke kiʻekiʻe o ka nui o ka kolamu ma ka 30-46%, LDL - e ka 41-61%, ka apolipoprotein B - e ka 34-50% a me ka triglycerides - e ka 14-33%, kumu i ka hoʻonui ʻana o ka hoʻoilo o HDL-C a me ka apolipoprotein A. ʻO ka d-i hilinaʻi mau i ka pae o LDL i nā mea maʻi me ka homozygous herlisary hypercholesterolemia, kūpaʻa i ka maʻi maʻi me nā lipid e hoʻohaʻahaʻa i ka lāʻau.

ʻO Atorvastatin calcium + nā mea hana.

He kiʻekiʻe nā Absorption. Hōʻemi ka meaʻai i ka wikiwiki a me ka lōʻihi o ka lawe ʻana mai i ka lāʻau (e 25% a me 9%, pākahi), akā me ka hoʻēmi ʻana o ka kolamu LDL e like like me ka hoʻohana ʻana o ka atorvastatin me ka ʻole o ka meaʻai. ʻO ka ʻike o ka atorvastatin i ka wā i ke ahiahi ma lalo iho o ke kakahiaka (ma kahi o 30%). Ua hōʻike ʻia kahi pilina palena ma waena o ke kūkaʻi o ka huina a me ka loaʻa ʻana o ka lāʻau lapaʻau. Hoʻomau ʻia ka nui i ka ate. Hoʻokuʻu ʻia ʻo ia ma o ka pūpū me ka bile ma hope o ka hepatic a / a i ʻole metabolism extrahepatic (ʻaʻole i hana i ka hoʻōla ʻana o ka enterohepatic). ʻO ka hana pale i ka hoʻoneʻe ʻia o HMG-CoA ka mālama ʻia ʻana e ka noho ʻana o nā metabolites ikaika. ʻOi ka liʻiliʻi o 2% o kahi kūpono i loko o ka waiʻai. ʻAʻole ia i excreted i ka wā hemodialysis.

• me ka hui ʻana me ka mea ʻai e hōʻemi ai i nā kiʻekiʻe kiʻekiʻe o ka kolamu, kolamu-LDL, apolipoprotein B a me nā triglycerides a hoʻonui i ka cholesterol-HDL i nā mea maʻi me ka hypercholesterolemia primel, ka heterozygous ʻohana a me ka non-familial hypercholesterolemia a hui pū (hui pū ʻia) hyperlipidemia (nā ʻano 2a a me 2) ,
• i ka hui pū ʻana me kahi meaʻai no ka mālama ʻana i nā maʻi me ka serum triglycerides kiʻekiʻe (type 4 ma o Fredrickson) a me nā mea maʻi me dysbetalipoproteinemia (ʻano 3 e like me Fredrickson), ka hana o ka mālamaʻai ʻana i nā mea kūpono ʻole.
• e hōʻemi i nā pae o ka nui o ka cholesterol a me LDL-C i nā mea maʻi me ka hypercholesterolemia homozygous familial, i ka wā mālama ʻia ʻana o ka meaʻai a me nā ʻano lāʻau lapaʻau ʻole hou ʻole i ke ʻano maʻi (ʻo ka hoʻohui ʻana i ka hana lipid-lowing therapy, me ka autohemotransfusion o LDL i hoʻomaʻemaʻe ʻia).
• nā maʻi o ka pūnaehana cardiovascular (ma nā mea maʻi me ka nui o nā mea pilikia no ka maʻi naʻau coronary - ʻoi aku ka ʻelemakule ma mua o 55 mau makahiki he nui, ka ulaula, he hipertension arterial, maʻi mellitus, maʻi maʻi peripheral, stroke, haʻalele ventricular hypertrophy, protein / albuminuria, coronary artery maʻi i nā hoahānau pili kokoke ), e komokū'ē i ke kua o dyslipidemia - prophylaxis kūloko me ka manaʻo e hōʻemi i ka nui o ka make o ka make, myocardial infarction, stroke, re-hospitalization for angina pectoris and the need for a revascularization kaʻina.

10 mg, 20 mg a me nā papa papa ʻaina 40 mg i hoʻopaʻa ʻia.

Nā ʻōkuhi no ka hoʻohana a me ka regimen

Ma mua o ka manawa i koho ʻia ai ʻo Torvacard, pono e ʻōlelo aku ka mea maʻi i kahi meaʻai lipid-hoʻemi haʻahaʻa, pono e hoʻomau ʻo ia e hoʻomau i nā manawa holoʻokoʻa.

ʻO ka maʻa mua he mau awelika o 10 mg hoʻokahi i ka lā. Hoʻololi ka ʻōhua mai ka 10 a 80 mg i hoʻokahi lā. Hiki i ka lāʻau lapaʻau ke loaʻa i kēlā me kēia manawa o ka lā, me ke ʻano o ka manawa ʻaina. Koho ʻia ka ʻōkole me ka lawe ʻana i nā pae mua o LDL-C, ke kumu o ka lāʻau a me ka hopena pilikino. I ka hoʻomaka ʻana o ka hoʻōla a me / a i ka manawa o ka hoʻonui ʻana i ka mahele o Torvacard, pono ia e nānā i nā pae lipid plasma a i kēlā me kēia mau hebedoma 2-4 a e hoʻoponopono pono i kēia ʻano. ʻO ka dosis kiʻekiʻe loa i kēlā me kēia lā he 80 mg ma 1 pāʻai.

Ma ka maʻamau o ka hypercholesterolemia a me ka hyperlipidemia i hui pū ʻia, ma ka hapa nui, ʻo kahi maʻi 10 mg o Torvacard hoʻokahi manawa i ka lā i lawa. Hoʻomaopopo ka hopena therapeutic koʻikoʻi ma hope o 2 mau pule, ma ke ʻano he kānāwai, a me ka hopena therapeutic lōʻihi loa e nānā ma hope o 4 wiki. Me ka lōʻihi o ka mālama ʻana, hoʻomau kēia hopena.

• lie kanikela
• ʻaiaiaia
• ʻōpala
• āhāhuʻe
• hiamoe
• mo na po
• amnesia
• manaʻo ʻino
• peripheral neuropathy,
• ataxia
• aloha
• paila, mamaila,
• constipation a i ʻole kaulike
• he ʻano hūnā
• ʻeha ka ʻōpū
• anorexia a i ʻole ka nui o ka makemake,
• myalgia
• huhuhu,
• myopathy
• myositis
• ʻeha ke kaumaha
• nā ʻōpū o nā keiki bipi i nā wāwae,
• kaʻiliʻili
• ʻohiʻala
• urticaria
• angioedema,
• anaphylactic haʻalulu,
• balous
• ka erythema exudative polymorphic, komo Hōʻike ʻia ʻo Stevens-Johnson
• nā mea ʻāhewa o ka epidermal epidermal (ʻelllelo Lyell)
• pālahalaha maʻi
• huahuʻi,
• ʻeha ka ʻōpū
• peripheral edema,
• huakai
• alopecia
• tinnitus
• loaʻa ka paona
• malaise
• nāwaliwali
• thrombocytopenia
• kōleʻa hope kūlohelohe.

• maʻi maʻi ʻeha a i ʻole ka hoʻonui ʻana i ka hana o nā transaminases i ka serum koko (ʻoi aku ma mua o 3 mau manawa e hoʻohālikelike ʻia me VGN) o kahi kumu ʻike ʻole,
• ka huhū palupalu (hōʻeha A a me B ma ke keiki-Pugh scale),
• maʻi maʻi hoʻoili, e like me ka lolose intolerance, hemahema lactase a malabsorption glucose-galactose (ma muli o ka loaʻa o ka lactose i ka hui),
• hapai
• lactation
• nā wahine o nā makahiki hānau o ka hoʻohana ʻana i nā kūpono kūpono o ka hoʻohālikelike ʻana,
• na keiki a me na opio malalo o na makahiki 18 (aole i hookumuia ana ka palekana a me ka palekana),

ʻŌpū a me ka lactation

ʻO Torvacard i hoʻohālike ʻia i ka wā hāpai a me ka lactation (umauma maʻi).

No ka mea nui ka kolamu a me nā mea i hoʻohuihui ʻia mai ka kolesterol ka mea nui no ka hoʻomohala ʻana o ka pūpū, ʻo ka hopena o ka hiki ke hoʻoweliweli i ka hoʻōla ʻana o HMG-CoA ma mua o ka loaʻa ʻana o ka lāʻau lapaʻau i ka wā hapai. Ke hoʻohana nei i ka lovastatin (kahi inhibitor o HMG-CoA reductase) me ka dextroamphetamine i ka trimester mua o ka hapai ʻana, hānau mai nā keiki me ka iwi o ka deformation o ka iwi, ʻike ʻia ka tracheo-esophageal fistula, a me ka anus atresia. Inā mālama ʻia ka male ma ka maʻi me Torvacard, pono e hoʻokuʻu koke ʻia ka lāʻau lapaʻau, a pono e kuhikuhi ʻia nā mea maʻi i ka hopena o ka maʻi o ka ʻōpio.

Inā pono e hoʻohana i ka lāʻau lapaʻau i ka wā lactation, i hāʻawi ʻia i ka hopena o nā hanana ʻeha i nā pēpē, pono e kūkā ʻia ke ʻano o ka hana ʻana i ka umauma.

Hiki ke hoʻohana ʻia i nā wāhine o ka makahiki o ka hānau a inā pono ke hoʻohana ʻia nā hana contraceptive pono. Pono e hoʻomaopopo ʻia ka mea maʻi i ka hopena o ka hopena no ka mālama ʻana i ka maʻi hānau.

Hoʻokomo ʻia ka lāʻau i nā keiki a me nā ʻōpio ma lalo o 18 makahiki o ka makahiki (ʻaʻole i hoʻokumu ʻia ka maikaʻi a me ka palekana).

Ma mua o ka hoʻomaka ʻana o Torvacard therapy, pono ia e hoʻāʻo e hoʻokō i ka hoʻopaʻa o ka hypercholesterolemia ma ke ʻano kūpono o kaʻai ʻana, hoʻonui i ke kino kino, ke kaumaha ʻana i ka mea maʻi me nā momona a me ka mālama ʻana i nā kūlana ʻē aʻe.

ʻO ka hoʻohana ʻana o HMG-CoA reductase inhibitors e hoʻohaʻahaʻa i nā lipids koko e hiki ke alakaʻi i kahi hoʻololi i nā ʻōhua biochemical e hōʻike ana i ka hana ate. Pono ka nānā ʻana o ka naʻau ma mua o ka hoʻomaka ʻana i nā hōʻola, 6 mau hebedoma, 12 mau pule ma hope o ka hoʻomaka ʻana e lawe i Torvacard a ma hope o ka hoʻonui ʻana o kēlā me kēia helu, a me kēlā me kēia manawa (ʻo ia hoʻi, 6 mau mahina). ʻO ka hoʻonui ʻana i ka hana o nā enzyme hepatic i loko o ka serum koko e hiki ke mālama ʻia i ka wā o ka maʻi me Torvacard (ma ka maʻamau 3 mau mahina mua). ʻO nā mea maʻi me ka piʻi o nā kiʻekiʻe transaminase pono e nānā pono a hiki i ka pae o ka enzyme e hoʻi i ka maʻamau. Ma ka hanana ʻoi aku ka nui o nā mana ALT a me AST ʻoi aku iʻoi aku ma mua o 3 mau manawa i ʻoi aku i ka VGN, ʻoi ʻia ka hoʻēmi ʻana o ka maʻi o Torvacard a i ʻole ka hana mālama ʻana.

Hiki i ka hopena me Torvacard ke hōʻeha i ka myopathy (ʻoi aku ka hōʻeha o ka naʻau a me ka nāwaliwali, i hui pū ʻia me ka hoʻonui ʻana o ka hana CPK e ʻoi aku ma mua o 10 mau manawa i hoʻohālikelike ʻia me VGN). Hiki i Torvacard ke hoʻonui i ka hoʻonui ʻana i ka serkika ʻo serum, pono e mālama ʻia i ka hoʻohālikelike ʻana o ka ʻeha o ka umauma. Hoʻomaʻamaʻa ʻia nā mea maʻi e pono koke lākou e kūkā i ke kauka inā ʻaʻole i loaʻa ka ʻeha a i ʻole nā ​​nāwaliwali o ka naʻau, inā ua hele pū lākou me ka malaise a me ka maʻi maʻi. Pono ke hoʻokaʻawale ʻana i ke ʻano o ka Torvard a i ʻole ke kali ʻole i ka wā inā loaʻa nā hōʻailona o ka myopathy hiki a i ʻole ke ʻano pilikia no ka hoʻomohala ʻana i ka haki ʻana ma muli o ka rhabdomyolysis (e. G. )

Hoʻokomo i ka hiki ke alakaʻi i kahi kaʻa a hana pū me nā mīkini

ʻO nā hopena maikaʻi loa o Torvacard ma ka hiki ke alakaʻi i nā kaʻa a komo i nā hana ʻē aʻe e koi ai i ka noʻonoʻo a me ka wikiwiki o ka hopena psychomotor ʻaʻole i hōʻike ʻia.

Me ka hoʻohana pū ʻana o ka cyclosporine, e hoʻohālikelike ai i ka erythromycin, clarithromycin, immunosuppressive a me nā lāʻau antifungal o ka hui azole, ka momona nicotinic a me ka nicotinamide, nā lāʻau lapaʻau e hoʻoneʻe ana i ka metabolism i hoʻolako ʻia e CYP450 isoenzyme 3A4, a me / a i ʻole ka lawe ʻana i ka wai, ka ʻona o ka atorvast. kū aʻe. Ke kuhikuhi ʻana i kēia mau lāʻau lapaʻau, pono e kaupaona ʻia ka pōmaikaʻi me ka hopena o ka mālama ʻana, ʻike pono nā mea maʻi e ʻike pono i ka ʻeha o ka hōʻeha ʻana a me ka nāwaliwali, ʻoiai paha i nā mahina mua o ka mālama ʻana a i ka wā e hoʻonui ai i ka nui o kēlā lāʻau lapaʻau, ʻike pinepine ʻia ka hana a KFK, ʻoiai ʻaʻole kēia ʻae ʻana i ka mālama ʻana i nā hana o KFK. pale i ka hoʻomohala ʻana i ka myopathy koʻikoʻi. Pono e hoʻokaʻawale ʻia ke ʻano Torvard inā he māhina i hoʻonui ʻia ka hana CPK a inā i hōʻoia ʻia a i manaʻo ʻia ka myopathy.

ʻAʻole i loaʻa i ka Torvacard ka hopena koʻikoʻi i ka neʻe o ka terfenadine i loko o ke kaila koko, ka mea i koho ai i ka nui o ka 3A4 CYP450 isoenzyme, a no laila ʻaʻole hiki i ka atorvastatin ke hopena koʻikoʻi i ka pālaʻi o ka pharmacokinetic o nā mea hou aʻe o ka 3A4 CYP450 isoenzyme. Me ka hoʻohana like ʻana o ka atorvastatin (10 mg hoʻokahi i ka lā) a me ka azithromycin (500 mg hoʻokahi i ka lā), ʻaʻole i loli ka ʻike o ka atorvastatin i loko o ke koko.

Me ka manawa like o ka atorvastatin a me nā hoʻomākaukau e loaʻa ana i ka magnesium a me nā hydroxides alumini, ua hoʻoneʻe ʻia ka ʻike ʻana i ka atorvastatin i ka plasma koko e pili ana i ka 35%, akā naʻe, ʻaʻole i loli ka nui o ke kahe o ka pae o LDL-C.

Me ka hoʻohana pū ʻana o colestipol, hoʻemi ʻia nā kukuna o ka atorvastatin e pili ana i 25%. Eia nō naʻe, ʻoi aku ka hopena o ka lipid-hoʻemi ʻana i ka hui o ka atorvastatin a me colestipol i kēlā me kēia pālolo.

Me ka hoʻohana like ʻana o Torvacard ʻaʻole i pili i ka pharmacokinetics o phenazone, no laila, ʻaʻole ka manaʻo ka launa pū me nā lāʻau ʻē aʻe e like me ka CYP450 isoenzymes.

Ke aʻo nei i ka hoʻopili ʻana o ka atorvastatin me warfarin, cimetidine, phenazone, ʻaʻohe mau hōʻailona o nā pilina koʻikoʻi lapaʻau i loaʻa.

ʻO ka hoʻohana pinepine ʻana i nā lāʻau lapaʻau e hōʻemi i ka neʻe ʻana o nā testosterone stogenous (me ka cimetidine, ketoconazole, spironolactone) e hoʻonui i ka hopena o ka hoʻohaʻahaʻa i nā hormones testosterone endogenous (pono e hoʻomaʻamaʻa ʻia ka mālama).

ʻAʻole i pili hewa i ka pili kino o ka atorvastatin me nā lāʻau antihypertensive, a me nā estrogens.

Me ka hana like o Torvacard ma kahi o 80 mg o kēlā me kēia lā a me nā ʻekikeke waha e loaʻa ana i ka norethindrone a me ka ethinyl estradiol, kahi ulu nui o ka neʻe ʻana o ka norethindrone a me ka ethinyl estradiol i nānā e pili ana i ka 30% a me 20%, kahi. Pono e noʻonoʻo ʻia kēia hopena i ke koho ʻana i kahi contraceptive wahaheʻe no nā wahine e loaʻa ana iā Torvacard.

Me ka hana like o ka atorvastatin ma kahi maʻa o 80 mg a me amlodipine ma kahi maʻa o 10 mg, ʻaʻole i loli ka ʻoihana pharmacokinetics o ka atorvastatin i ka mokuʻāina.

Me ka hoʻokele mau ʻana o ka digoxin a me atorvastatin ma kahi maʻa o 10 mg, ʻaʻole i loli ka nui o nā kūpapa neʻe o ka digoxin i loko o ke koko koko. Eia naʻe, i ka manawa i hoʻohana ʻia ka digoxin i hui pū me ka atorvastatin ma kahi maʻa o 80 mg i kēlā me kēia lā, hoʻonui ʻia ka ʻike o ka digoxin ma kahi o 20%. ʻO nā maʻi e loaʻa ana i ka digoxin i hui pū me ka atorvastatin e pono ai ke nānā.

ʻAʻole i mālama ʻia nā haʻawina o ke kamaʻilio ʻana me nā lāʻau ʻē aʻe.

Nā kuʻuna o ka lāʻau Torvacard

Hoʻololi nā kumu hoʻohālike o ka waiwai ikaika:

Nā huahana i loko o ka hui laila (statins):

Liprimar: mau hōʻailona no ka hoʻohana ʻana

Ua kuhikuhi ʻia ka lāʻau lapaʻau no nā maʻi aʻe.

• hipololeka,
• a? ano i hoʻohui? ia o hyperlipidemia,
• dysbetalipoproteinemia,
• paulakowalik
• nā hui pilikia no ka hoʻomohala ʻana i ka maʻi naʻau coronary (nā poʻe ma luna o 55, nā mea ulaula, nā mea maʻi me ka maʻi mellitus, ka mana ʻōpiopio, a me nā mea ʻē aʻe).
• maʻi maʻi coronary.

Hiki iā ʻoe ke hoʻohaʻahaʻa i ka kolamu, nānā i kahi meaʻai, hoʻonaʻauao kino, me ka momona me ka hoʻohaʻahaʻa ʻana i ke kaumaha o ka nui o ke kino, inā ʻaʻole kēia mau hana i hāʻawi i nā hopena, e kuhikuhi ana i nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka kolesterol.

Pono pono e hahai i nā ʻōlelo kauoha no ka hoʻohana ʻana o Liprimar. ʻAʻohe wahi palena no ka lawe ʻana i nā pil. Hoʻokumu i nā kuhikuhi o LDL (kino hōʻeha), ke helu ʻia o kēlā me kēia lā o ka lāʻau (maʻamau ka nui 10-80 mg). ʻO ka mea maʻi me kahi puka mua o ka hypercholesterolemia a i ʻole ka hyperlipidemia i hui ʻia e 10 mg, lawe ʻia i kēlā me kēia lā no 2-4 mau hebedoma. ʻO ka poʻe maʻi e hoʻomanawanui i ka hypercholesterolemia hoʻoilina e kuhikuhi i ka nui loa o ke 80 mg.

Koho i nā kaila o nā lāʻau lapaʻau e pili ana i ka metabolism momona e pono e hoʻomake ʻia e nā lipid pae i ke koko.

Me ka mālama aka, ua ʻōlelo ʻia ka lāʻau lapaʻau no ka poʻe maʻi me ka hiki ʻole o ka pale a i ʻole ka hoʻokau ʻia me Cyclosparin (ʻaʻole iʻoi aku ma mua o 10 mg i kēlā me kēia lā), e loaʻa ana i nā maʻi o nā maʻi, nā mea maʻi a i nā makahiki o ke keʻakeʻa ʻana.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

Loaʻa ma ke ʻano o nā papa, i nā palaha o 7-10 mau ʻāpana, ʻokoʻa pū ka nui o nā blisters i loko o ka paena, mai 2 a 10.ʻO ka mea e hana ana he paʻakai kaleka (atorvastatin) a me nā mea hou aku: sodium croscarmellose, calcium carbonate, candelila wax, crystals liʻiliʻi o selulose, hyprolose, lactose monohala, polysorbate-80, opadra keʻokeʻo, magnesium stearate, simethicone emulsion.

ʻO nā papa liprimar Elliptical i kālai ʻia me kahi pūpū keʻokeʻo, hilinaʻi ʻia i ka dosage i nā milligrams, i loaʻa ke kahakaha o 10, 20, 40 a i ʻole 80.

He waiwai waiwai

ʻO ka waiwai nui o Liprimar kona hypolipidemia. Kōkua ka lāʻau lapaʻau e hōʻemi i ka hana o nā enzymes e kuleana ai no ka synthesis o kolamu. Ke alakaʻi nei kēia i kahi emi o ka hana o ka kolamu ma ka pepi, kēlā, e hoʻoneʻe i kona pae i ke koko, a hoʻomaikaʻi ka hana o ke ʻano cardiovascular.

Ua kuhikuhi ʻia ka lāʻau lapaʻau no nā kānaka me ka hypercholesterolemia, kahi mea mālama ʻole lapaʻau a me nā lāʻau lapaʻau-hoʻohaʻahaʻa ʻē aʻe. Ma hope o kahi papa o ka papaʻaina, hāʻule nā ​​pae kolamu e 30-45%, a me LDL - e ka 40-60%, a me ka nui o kahi a-lipoprotein i loko o ke koko.

Hāʻawi ka hoʻohana ʻana o Liprimar i ka hōʻemi ʻana i ka hoʻomohala ʻana o nā pilikia hōʻeha o ka naʻau coronary e ka 15%, ua emi iho ka make mai nā pathologies cardiac, a me ka hōʻemi ʻana o ka hōʻeha ʻana i ka naʻau a me nā hōʻino huhū o angina e hoʻemi nei ma 25%. ʻAʻole i ʻike ʻia nā waiwai mutagenic a me ka carcinogenic.

Nā ʻihi ʻaoʻao a Liprimara

E like me nā lāʻau lapaʻau, loaʻa i kēia hopena nā hopena. No Liprimar, ʻo nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, e ʻae maikaʻi ʻia ka maikaʻi. Eia nō naʻe, ua hōʻike ʻia kahi nui o nā hopena ʻaoʻao: ka maʻi ʻeha, ka maʻi paleha o ka maʻi (asthenia), nā māhā i ka ʻōpū, ka ʻōpū a me ka dyspepsia, pua (flatulence) a me ka constipation, myalgia, nausea.

Nā hōʻailona o ka anaphylaxis, anorexia, arthralgia, ʻehaʻeha a me nā hōʻeha, hypo- or hyperglycemia, dizziness, jaundice, rash skin, itching, urticaria, myopathy, kahaha ka hoʻomanaʻo ʻana, hoʻemi a hoʻonui paha i ka hōʻanoho ʻana, ka neuropathy, pancreatitis, hoʻomaʻamaʻa, ʻomaʻama ʻaʻole pinepine ke nānā ʻia. thrombocytopenia.

ʻO nā ʻaoʻao ʻaoʻao o Liprimar i nānā ʻia, e like me ke kaʻe ʻana o nā limahana, ka momona, ka ʻeha o ka ʻōpū, alopecia, tinnitus, a me ka hoʻomohala ʻana o ka hana renal lua ʻole.

Nā Hōʻike

Atorvastatin - kahi hui o Liprimar - kekahi o nā lāʻau kaulana loa no ka hoʻohaʻahaʻa ʻana i nā lipoproteins haʻahaʻa-haʻahaʻa. Ua hōʻike ʻia nā hoʻokolohua mālama ʻia e Grace a me 4S ka nui o ka atorvastatin ma luna o simvastatin i ka pale ʻana i ka hoʻomohala ʻana i ka maʻi cerebrovascular acute a me ka maʻa. Ma lalo mākou e noʻonoʻo ai i ka lāʻau o ka pūʻulu statin.

Nā huahana e pili ana i Atorvastatin

ʻO ka analogue Lūkini o Liprimar, Atorvastatin, e hana i nā huahana lāʻau lapaʻau: Kanofarma Production, ALSI Pharma, Vertex. Nā papa waha me ka nui he 10, 20, 40 a i ʻole 80 mg. Lawe hoʻokahi lā i kahi lā ma kahi o ka wā like, me ka ʻole o nā meaʻai.

Kū pinepine nā mea hoʻohana iā lākou iho - Atorvastatin a i ʻole Liprimar - ʻoi aku ka maikaʻi?

Hoʻohālikelike ka hana o ka lāʻau lapaʻau ma Atorvastatin i ka hana a Liprimar, no ka mea, ʻo nā hua lāʻau i ke kumu ke like me nā mea like. Ka hana o ka hana o ka lāʻau mua me ka hoʻonāukiuki ʻana i ka synthesis o nā kolamu a me nā lipoproteins atherogenic e nā mea ponoʻī ponoi o ke kino. Ma nā pūpū o nā momona, hoʻonui i ka hoʻohana ʻana o LDL, a me ka nui o ka hana i nā lipoproteins anti-atherogen kiʻekiʻe i hoʻonui ʻia.

Ma mua o ke koho ʻana iā Atorvastatin, ua hoʻoponopono ʻia ka mea maʻi i kahi mea ʻai a kuhikuhi i kahi papa hana, ʻike ia i kēia manawa i ka hopena maikaʻi, a laila ke kuhikuhi ʻana i nā statins i mea pono ʻole ʻole.

Inā hiki ʻole ke hoʻākohala pono i ka pae o ka cholesterol me ka lāʻau ʻole-lāʻau, nā lāʻau lapaʻau o kekahi pūʻulu o nā statins i kuhikuhi ʻia, ʻo ia ka Atorvastatin.

I ka hoʻomaka mua o ka hoʻōla, hāʻawi ʻia ʻo Atorvastatin i 10 mg hoʻokahi i ka lā. Ma hope o nā hebedoma e 3-4, inā e koho pololei ʻia ka nui o nā hewa, e ʻike ʻia ana ka loli o ka lehelehe lipidI ka ʻōlelo lipid, ua hoʻomaopopo ʻia ka emi ʻana o ka cholesterol nui, ua emi ka nui o ka lipoproteins haʻahaʻa haʻahaʻa a haʻahaʻa, i ka nui o ka triglycerides e emi.

Inā ʻaʻole i loli a ʻaʻole hoʻi i hoʻonui iki paha ka nui o kēia mau mea, pono e hoʻoponopono i ka maʻi o Atorvastatin. Loaʻa i ka lāʻau lapaʻau i loaʻa i nā ala he nui, kūpono loa ia no nā mea maʻi e loli. 4 mau pule ma hope o ka hoʻonui ʻana i ka nui o ka pane, ua hoʻomau ʻia ka loiloi spekulopa, inā pono, hoʻonui hou ʻia ka nui, ʻo 80 ka nui o kēlā me kēia lā.

Ka like o ka hana o ka hana, ke ʻano a me nā hopena ʻokoʻa o Liprimar a me kāna hoa ʻeka Lūkini. Loaʻa nā pono o Atorvastatin i kāna kumukūʻai kūpono. Wahi a nā loiloi, pinepine pinepine ka lāʻau Lūkini i nā hopena ʻaoʻao a me nā maʻi pākuʻi ʻia me Liprimar. Aʻo kahi drawback kahi lōʻihi lōʻihi.

ʻO nā koho ʻē aʻe no Liprimar

Ieiʻi - kahi moʻolelo o Liprimar - lāʻau lapaʻau i hana ʻia e ka hale kūʻai lāʻau lapaʻau Slovenian o KRKA. ʻO ia nō hoʻi ka lāʻau lapaʻau e like pū me kāna hana a ka lāʻau lapaʻau me Liprimaru. Loaʻa nā Atoris me kahi pālahalaha he nui ʻē aʻe i hoʻohālikelike ʻia me Liprimar. Mālama kēia i ke kauka i kahi maʻalahi o ka helu ʻana i ka ʻeha, a hiki i ka mea maʻi ke hopu i ka lāʻau lapaʻau.

ʻO Atoris wale nō ke ʻano o ka lāʻau lapaʻau (Liprimara generic) i hana i ka nui o nā hoʻokolohua hoʻomaʻamaʻa a ua hōʻoia i ka hana pono. Ua hele pū nā mea kōkua mai nā ʻāina he nui i kāna aʻo ʻana. Ua hana ʻia ke aʻo ʻana ma nā kumu o nā haukapila a me nā haukapila. I ka hopena o nā haʻawina, 7,000 mau kumuhana e lawe ana i ka Atoris 10 mg no 2 mau mahina i hōʻike i ka emi ʻana o ka atherogenic a me nā lipoproteins cholesterol holoʻokoʻa e 20-25%. ʻO ka liʻiliʻi o ka hopena pili i Atoris he liʻiliʻi.

ʻO Liptonorm kahi lāʻau Lūkini e hoʻomaʻamaʻa i nā metabolism momona i ke kino. ʻO ka mea hana i loko o ia mea he atorvastine, kahi mea me ka hana hypolipidemic a me ka hana hypocholesterolemic. He like nā hōʻailona like me ka liptonorm no ka hoʻohana ʻana a me ka maʻi ʻana me ka liprimar, a me nā hopena like.

Loaʻa ka lāʻau lapaʻau i nā mea ʻelua wale nō o 10 a 20 mg. He mea paʻakikī loa ia no ka hoʻohana ʻana e nā mea maʻi e hōʻeha nei i nā ʻano hana ʻino o ka atherosclerosis, hechrolesterolemia famihilau heterozygous, pono lākou e lawe i nā papa he 4-8 i kēlā me kēia lā, ʻoiai ka lula i kēlā me kēia lā he 80 mg.

ʻO Torvacard ka analoge kaulana loa o Liprimar. Hoʻopau i nā hua lāʻau lapaʻau Slovak "Zentiva". Ua hoʻokūpaʻa ʻo "Torvacard" iā ia iho no ka hoʻoponopono ʻana o ka cholesterol i nā mea maʻi e loaʻa mai ana i ka pathology cardiovascular. Hoʻohana maikaʻi ia e mālama i nā mea maʻi me ka cerebrovascular maʻi a me ka coronary insufficiency, me ka pale ʻana i nā hoʻopiʻi e like me ka hōʻeha a me ka puʻuwai puʻuwai. ʻO ka lāʻau lapaʻau ka hōʻemi haʻahaʻa i ka pae o ka triglycerides i ke koko. Hoʻohana hou ia ma ka mālamaʻana i nā hua hoʻoilina o ka dyslipidemia, no ka laʻana, e hoʻonui ai i ka pae o ka "lipoproteins" high-density lipoproteins.

Nā ʻano hana i hoʻokuʻu ʻia "Torvokard" 10, 20 a me 40 mg. Hoʻomaka ka lāʻau atherosclerosis, maʻamau me ka 10 mg, ma hope o ka hoʻopaʻa ʻana i ke kiʻekiʻe o ka triglycerides, cholesterol, nā lipoproteins haʻahaʻa haʻahaʻa. Ma hope o 2 mau hebedoma e hana ana i ka nānā ʻana i ka nānā ʻana o ka nui o ka molopō. Me ka loaʻaʻole o ka mālamaʻana, e hoʻonui i ka dosage. ʻO ka palena kiʻekiʻe loa i kēlā me kēia lā he 80 mg.

ʻAʻole like me Liprimar, ʻoi aku ka maikaʻi o Torvacard i nā mea maʻi me nā maʻi o ka ʻōnaehana cardiovascular, ʻo ia nō "+".

ʻO nā huahana e hana nei me Rosuvastatin

"Rosuvastatin" kahi kolu o ka hanauna o ka hanauna i loaʻa ka hopena lipid. Hoʻomoe maikaʻi ʻia nā hana i hoʻokumu ʻia ma luna o ka wai o ke koko. ʻO kā lākou hopena nui ka hōʻemi ʻana i ka nui o ka kolamu a me nā lipoproteins atherogenic. ʻO kekahi ʻano maikaʻi hou, ʻo "Rosuvastatin" no ka hopena ʻole o ka hopena o ka pehu a me ka hōʻino ʻole i ka ʻōpū o ka ʻiʻo.No laila, ʻo nā statins e pili ana i ka rosuvastatin e liʻiliʻi i ka hoʻopiʻi ʻana i nā hana hoʻopiʻi i loko o ke ʻano o ka maikaʻi ʻole o ka ate, ka piʻi ʻana o nā level transaminases, myositis, a me myalgia.

Ke hana nei i ka hana pharmacological nui ma ke kāohi ʻana i ke kāpili a hoʻonui i ka hoʻonui ʻana i nā pupu atherogen o ka momona. Loaʻa ka hopena o ka mālama ʻana i ka mālama ʻo Atorvastatin, ʻo nā hopena mua e ʻike ʻia ma ka hopena o ka pule mua, hiki i ka hopena kūpono loa ke ʻike ʻia i nā hebedoma 3-4.

Koho ʻia nā lāʻau lapaʻau e pili ana i ka rosuvastatin:

• "Crestor" (hana o Britain Nui),
• Mertenil (hana ʻia ma Hungary),
• "Tevastor" (hana ʻia ma ʻIseraʻela).

"Crestor" a "Liprimar" i mea e koho ai? Pono ke koho ʻana e nā māka i hele.

ʻO nā huahana e pili ana nā Simvastatin

ʻO kekahi lāʻau lapaʻau lipid ʻano haʻahaʻa ʻē aʻe ʻo Simvastatin. E pili ana iā ia, ua hoʻokumu ʻia he nui o nā lāʻau lapaʻau e hoʻohana pono e mālama i ka atherosclerosis. ʻO nā hoʻokolohua haukapila o kēia lāʻau lapaʻau, i mālama ʻia ma mua o ʻelima mau makahiki a e pili ana i nā mea he 20,000 o ka poʻe, ua kōkua i ka hopena e hiki i nā lāʻau lapaʻau e simvastatin e hōʻemi i ka hōʻeha ʻana i ka puʻuwai a me nā hōʻeha i nā mea maʻi e hōʻeha nei i nā puʻuwai cardiovascular a me cerebrovascular.

ʻO nā hui o Liprimar e pili ana i ka simvastatin:

• Vasilip (hana ʻia ma Slovenia),
• Zokor (hana - Netherlands).

ʻO kekahi o nā hoʻoholo i nā mea e pili ana i ke kūʻai ʻana i kahi lāʻau lapaʻau ka mea kumu kūʻai. Hoʻopili hou kēia i nā lāʻau lapaʻau e hoʻihoʻi i nā pilikia o nā momona o ka momona o ka momona. Hoʻolālā ʻia ka loiloi o nā maʻi like i nā mahina he nui, a i kekahi mau makahiki. ʻO nā kumukūʻai no nā lāʻau lapaʻau e like me nā hana pharmacological ʻokoʻa ma waena o nā lāʻau lapaʻau i nā manawa ma muli o nā kulekele kumu kūʻai o kēia mau ʻoihana. ʻO ke koho ʻana i nā lāʻau lapaʻau a me ke ʻano koho ana e pono e mālama ʻia e ke kauka, eia naʻe, ke koho o ka mea maʻi i nā lāʻau lapaʻau mai kekahi ʻano lāʻau lapaʻau e ʻokoʻa, i ʻokoʻa i ka mea hana a me nā kumukūʻai.

ʻO nā lāʻau lapaʻau āpau o luna a me nā mea ʻē aʻe, ua kau ʻia ka liprimar, ua hele i nā hoʻokolohua lapaʻau a ua hoʻokū lākou iā lākou iho i mau ʻoihana kūpono e hoʻomaʻamaʻa i ka momona metabolism. Loaʻa ka hopena maikaʻi ma ke ʻano o ka hoʻohaʻahaʻa i ka cholesterol i 89% o nā mea maʻi i ka malama mua o ka mālama ʻana.

ʻO ka pōʻino o ka kiʻekiʻe kiʻekiʻe o kāna kolamu ma kāna mea hiki. Hiki ke ʻike ʻia nā mālama liʻiliʻi o nā poli kolamu ma hope o 20 mau makahiki. A i ka wā e ʻike ʻia ai nā hōʻailona - ma ke 40, 50, 60 mau makahiki - ʻoi aku kēia mau pākaha he ʻoi aku ma mua o kahi haneli. Akā ʻo kahi mea i loaʻa i kahi pilikia - ka maʻi ʻeha o ka coronary a i ʻole plque i loko o nā moku o ka ʻāʻī, ua kū maoli ʻo ia - ma hope o nā mea a pau, ʻaʻohe mea nāna e hoʻopilikia ma mua. ʻAʻole manaʻo ʻo ia he lōʻihi kona kolamu no ka lōʻihi.

ʻO kekahi o ka hoʻohana mauʻana i ka cholesterol hoʻohaʻahaʻa kūpono loa he stins. ʻO kā lākou hoʻohana, me ka hopena i hopena maikaʻi, e ukali ʻia e kekahi mau ʻaoʻao o laila, no laila he mea nui e ʻike pehea e lawe pololei ai i statins.

Pehea e hana ai nā statins

Ma loko o ka lāʻau lapaʻau, hiki i kēia mau lāʻau i kapaʻia ʻo HMG-Co-A inhibuctase inhibitors. ʻO ke kumu kēia o ka moleki statin pale i ka enzyme. Hōʻalo kēia hopena i ka emi ʻana o ka puna o ka kolamu i loko o ka puna a ʻo ka hoʻōla wikiwiki ʻana i ka cholesterol haʻahaʻa haʻahaʻa (ʻo ka mea weliweli). ʻO ka hopena: ua hoʻemi ʻia ka kolamu koko. Kuhi pololei nā loiloi i ka ate.

Eia kekahi, loaʻa nā statins i ka hopena anti-inflammatory a me ka antioxidant - ʻo ia ka mea e ʻoi aku ka plae i paʻa ʻia a paʻa ʻole paha e hoʻoulu i ka trombosis (ʻo ia ke kumu o ka hōʻeha ʻana a i ʻole hōʻāʻeha).

ʻO ke kauka hele wale nō e kuhikuhi i nā lāʻau statin: ua make kekahi mau hopena o nā statins. Ma mua o ka hāʻawi aku ʻana iā lākou, e loiloi ke kauka i nā ʻōuli āpau o nā hōʻike koko a me nā maʻi e noho nei.

ʻO nā kūmole o nā lāʻau lapaʻau a me nā hoʻohālike o nā papa

• ʻO Simvastatin ka lāʻau palupalu loa.Hoʻomaopopo kēia i ka hoʻohana wale ʻana i kēlā poʻe iā lākou ka māhuahua iki o kona kolamu. ʻO kēia nā papa like e like me Zokor, Vasilip, Simvakard, Sivageksal, Simvastol. Ke noho nei lākou ma nā helu he 10, 20 a 40 mg.
• ʻOi aku ka ikaika ma Atorvastatin. Hiki ke hoʻohana inā he kiʻekiʻe loa ka kiʻekiʻe o ka cholesterol. ʻO kēia nā papa mai kolesterol Liprimar, Atoris, Torvakard, Novostat, Liptonorm. ʻO nā dosis he 10, 20, 30, 40 a me 80 mg.
• ʻO Rosuvostatin ka ikaika loa. Kuhi nā kauka i ke kolamu nui kiʻekiʻe, inā pono ʻoe e hoʻohaʻahaʻa koke iā ia. ʻO kēia nā papa Krestor, Roxer, Mertenil, Rosulip, Tevastor Rosucard. Aia nā ʻōmole pili loa: 5, 10, 20 a 40 mg.
• Loaʻa iā Lovastatin ma Cardiostatin, Choletar, Mevacor. ʻO kēia lāʻau lapaʻau i loko wale nō o ka 20 mg i kēlā me kēia papa pā.
• ʻO Fluvastatin i kēia manawa hoʻokahi wale nō papa o ka papaʻi - ʻo Lescor kēia (20 a 40 mau mea i kēlā me kēia)

E like me kāu e ʻike ai, like nā like o ka lāʻau lapaʻau. Akā ma muli o nāʻokoʻa kūpono ole, 10 mg o rosuvostatin hoʻemi haʻahaʻa i ka cholesterol ma mua o 10 mg o ka atorvastatin. A ʻoi aku ka nui o 10 mg o Atoris ma mua o 10 mg o Vasilip. No laila, hiki i ke kauka hele ke kahakaha i nā statins, loiloi i nā mea āpau, contraindications a me ka hopena o nā hopena hopena.

Pehea e lawe ai i statins?

No ka hoʻohaʻahaʻa i ka cholesterol, lawe ʻia nā statins i hoʻokahi lā. ʻOi aku ka maikaʻi inā he ahiahi - no ka mea ua hoʻomau ʻia nā lipids i ke ahiahi. Akā no ka atorvastatin a me ka rosuvostatin, ʻaʻole kūpono kēia: hana like kā lākou a pau i ka lā.

ʻAʻole hiki iā ʻoe ke manaʻo e inu ke kanaka i nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka cholesterol, a laila ʻaʻole pono kahi meaʻai. Inā ʻaʻohe mea o ka loli ʻana o ke ʻano o ke kanaka, ʻaʻohe pono o ka mālama ʻana me nā statins. Pono ka papaʻai e hoʻokomo i ka uahi a me ka waiʻona, e hōʻemi ana i ka nui o ka paʻakai i ka meaʻai. Pono e ʻoli nā meaʻai, ʻokoʻa ʻole ma ʻekolu o nā iʻa i hoʻokahi hebedoma a he 400 g nā mea kanu ai ʻole nā ​​huaʻai i kēlā me kēia lā. Hōʻike ʻia ka mea maʻamau ʻaʻohe mea e hoʻemi ana i ka pauna o ka calorie o ka meaʻai inā ʻaʻohe mea kaupaona nui.

Maikaʻi loa ka hana kino kino i ka ea hou: hoʻomaikaʻi lākou i ke ʻano o nā kīʻaha koko. No nā 30-45 mau minuke 3-4 mau manawa i ka hebedoma.

ʻO ka ʻōmole o nā statins ka mea kū hoʻokahi, hoʻokahi kauka wale nō e kuhikuhi iā ia. ʻAʻole ia e pili wale i ka kolamu, akā ke kau ʻana i nā maʻi kanaka.

No ka laʻana, ua kuhikuhi ke kauka i ka 20 mg o Atoris iā ʻoe, a me kekahi hoalauna me ka ʻolua like ʻole - 10 mg. ʻAʻole kēia ma kahi ʻike loea maʻamau. Ka mea wale ia nā maʻi like ʻole, no laila ua ʻokoʻa ka hapa o nā statins.

ʻO nā contraindications pili

Hoʻohana ʻia nā ʻōmala:

• Me nā maʻi o ka leʻa ma mua.
• Me ka hepatosis momona me kahi piʻi liʻiliʻi o ka pae o nā enzymes.
• In type 2 diabetes mellitus, decompensated ke mālama ʻole ʻia ka nui o ke kō.
• ʻO nā wahine maʻa aku ma mua o 65 ua loaʻa i nā lāʻau lapaʻau he nui.

Eia naʻe, me ka makaʻala - ʻaʻole ia e manaʻo e koho.

Ma hope o nā mea a pau, ʻo ka hoʻohana ʻana i nā statins mai ka cholesterol ka mea e pale ai lākou i kekahi kanaka mai nā maʻi e like me myocardial infarction, ritika hoʻolauna (e hiki ai i ka hopu cardiac), ka cerebral stroke, thrombosis. Ke alakaʻi nei kēia mau alakaʻi i kēlā me kēia lā i ka make o nā tausani o nā kānaka a ua manaʻo ʻia he kumu nui o ka make. Akā ʻo ka hopena o ka make mai ka maʻi hepatosis ka mea liʻiliʻi.

No laila, mai makaʻu ʻoe inā loaʻa iā ʻoe kahi maʻi paleka, a no kēia manawa ua kuhikuhi ʻia nā statins. E aʻo aku ke kauka iā ʻoe e hana i kahi hōʻike koko ma mua o ka lawe ʻana i nā kuʻuna no ka cholesterol a me hoʻokahi mahina ma hope o ka hana. Inā kūpaʻa ka pae o nā enzyme o ka ate, a laila kāpae me ka ukana ka maikaʻi loa, a e emi ka cholesterol.

E hui pū me nā lāʻau lapaʻau ʻē aʻe

Hoʻonui ka pōʻino mai nā statins inā lawe ʻia i ka manawa like me nā lāʻau ʻē aʻe: thiazide diaretics (hypothiazide), macrolides (azithromycin), nā antagonist calcium (amlodipine). Pono ʻoe e pale i ka hoʻokō pono ʻana o nā kānāwai no ka cholesterol - pono ke kauka e loiloi i nā lāʻau lapaʻau a kekahi e lawe ai. E hoʻoholo ʻo ia i ke ʻano hui like ʻole o ia hui hui.

Pehea ka lōʻihi e lawe ai au i nā statins?

Kū pinepine kekahi kūlana i ka wā e inu ai ke kanaka i kahi pū o Krestor a manaʻo e ola maikaʻi nei ʻo ia i kēia manawa. ʻO ka manaʻo maikaʻi ʻole. ʻO ka hoʻonui ʻana i ka cholesterol (atherosclerosis) kahi maʻi maʻi maʻamau, hiki ʻole ke hoʻōla me ka papa ʻaina hoʻokahi.

Akā ʻoiai he mea maoli ia e hoʻomau i nā pae o ka kolamu e like ʻole e hoʻopili ʻia ai nā ʻōpala hou, a e maloʻo ka poʻe kahiko. No ka hanaʻana i kēia, he mea nui e hahai i kahi meaʻai a lawe i nā statins i nā manawa lōʻihi.

Akā ʻo ka nui i ka wā ma mua - i ka manawa, e emi nui paha.

ʻO ka mea e pono ai ʻoe e kaohi inā inu ʻoe i nā statins

I ka wā e hoʻōla ai a ma mua o ka hoʻomaka ʻana, ke ana ʻia ka nui o nā lipids: ka helu kolesterol, triglycerides a me nā lipid kiʻekiʻe a me ka haʻahaʻa haʻahaʻa. Inā ʻaʻole emi ka pae kolamu, a laila hiki paha ke laʻu ka nui o ka dosage. Hiki paha ke kauka iā ʻoe e hoʻāla a kali.

ʻOiai ʻo nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka kolesterol e hoʻopilikia i ka ate, pono ʻoe e hana i kēlā me kēia manawa i ka hoʻokahe koko biochemical i mea e hoʻoholo ai i ke pae o nā enzyme. ʻO ka kauka kauka e hele aku ana i kēia.

• Ma mua o ka koho ʻana o nā statins: AST, ALT, KFK.
• 4-6 mau pule ma hope o ka hoʻomaka ʻana o ka hoʻokomo: AST, ALT.

Me ka piʻi nui o ka pākaukau o ka AST a me ka ALT e ʻoi aku ma mua o ʻekolu mau manawa, hōʻike hou ka hōʻike koko. Inā loaʻa nā hopena like i ka wā o ka hoʻāʻo i ke koko, a laila e hoʻopau ʻia nā statins a hiki i ka pae like. Pēlā paha e hoʻoholo ai ke kauka hiki ke loli i nā statins me nā lāʻau lapaʻau ʻē aʻe.

ʻO ka kolamu he mea pono e pono ai i ke kino. Akā me kāna hoʻonui, kū mai nā maʻi weliweli. ʻAʻole pono e lawe i nā hoʻāʻo māmā koko no ka nui kolamu. Inā, e like me kāna mau hopena, e ʻōlelo ke kauka a lawe i mau statins, a laila pono maoli lākou. He hopena maikaʻi loa kēia mau lāʻau lapaʻau, akā he nui nā hopena koʻikoʻi. No laila, pāpā paʻa loa ia e inu iā lākou me ka ʻole o ke kau ʻana i kahi kauka.

Nā kumuhana: pehea ka hana, nā hōʻailona a me nā contraindications, he loiloi o ka lāʻau lapaʻau, kahi mea e hoʻololi

ʻO Cholesterol, a ʻo cholesterol paha, he waiwai ia e hana ai i nā hana koʻikoʻi i loko o ke kino o ke kanaka. E pili ana kēia:

• ʻO ke komo he mea hana hale hana i ke kaʻina hana o ka hapanui o nā ʻāpana o ke kino, no ka mea, ua hoʻopili ʻia nā molekoleka kolamu i ka membrane a hāʻawi aku iā ia ka ikaika, ʻāʻī a me ka "ʻano nui",
• Ka komo ʻana i ke kaʻina hana a me ka hoʻokumu ʻana i nā waikawa bile e pono ai no ka ʻokiʻoki a me ke kao ʻana ʻana o nā momona i ka ʻōpū ʻoki o ka gastrointestinal,
• Ke komo ʻana i ka hoʻokumu ʻana o nā hormones i loko o ke kino - ka ulu ʻana o nā testosterone o nā pelekela adrenal, a me nā hormone hoʻonaninani.

ʻO ka kolamu nui o ke koko ka mea e alakaʻi ai i ka nui o nā molekōloe e waiho ma luna o nā paia o nā kahe koko (ka nui o nā ʻili). Kūkulu ʻia nā ʻōpala Atherosclerotic e hoʻopili ana i ka kahe o ke koko ma o ka ʻalike a me kekahi manawa, ka hui pū me nā clots koko i hoʻopili ʻia iā lākou, paʻa loa i ka lumen o ka moku, e kōkua ana i ka hoʻomohala ʻana o ka hōʻeha ʻana i ka naʻau a me ka hōʻeha.

ʻAno kumu o ka kolamu nui o ke kolamu ma ke koko o kahi pākeke e pono ʻole ma mua o 5.0 mmol / l, i nā mea maʻi me ka maʻi ʻōpū coronary ʻaʻole iʻoi aku ma mua o 4,5 mmol / l, a me nā mea maʻi me ka myocardial infarction ʻaʻole iʻoi aku ma mua o 4.0 mmol / l.

He aha nā helu a pehea e hana ai lākou?

I nā hihia i loaʻa i ka mea maʻi e hoʻonui i ka hoʻomohala ʻana i ka myocardial infarction ma muli o ka atherosclerosis a me nā maʻi pākia o ka cholesterol, hōʻike ʻia ʻo ia ka hoʻohana lōʻihi ʻana o nā lāʻau lipid-hoʻohaʻahaʻa.

ʻO nā statins he hypolipidemic (lipid-lowing) lālau, ka hana o kahi e hoʻowalewale ai i ka enzyme e paipai ana i ka hoʻokumu ʻana o ka cholesterol. Hoʻohana lākou ma ka loina o "ʻaʻohe enzyme - ʻaʻohe kolamu." Eia kekahi, ma muli o nā hana kūlohelohe, hāʻawi lākou i ka hoʻomaikaʻi ʻana i ka papale o loko o ke kīhāpai koko i hōʻino ʻia i ka wā i hiki ʻole ke hiki ʻana i ka atherosclerosis ke hoʻomaka, e hoʻomaka ana, akā, ʻo ka wehe ʻana o ka cholesterol i nā pā e hoʻomaka ʻia - ma kahi manawa mua o ka atherosclerosis.Pō hoʻi lākou i ka hopena maikaʻi i nā waiwai o ka rheological o ke koko, e hoʻemi ana i ka viscosity, kahi kumu koʻikoʻi ia e pale ai i ke ʻano o ke kīwaha koko a me kā lākou hoʻopili ʻana i nā pākeke.

Hoʻomaopopo ka ʻoi loa me ka huaʻala o nā statins hou loa, aia i ka atorvastatin, cerivastatin, rosuvastatin a me pitavastatin ma ke ʻano he mea ikaika. ʻAʻole ke hōʻemi wale ʻia nā lāʻau o ka hanauna hou i ka pae o ka cholesterol "kino", akā ke hoʻonui pū nei i nā mea o ka "maikaʻi" i ke koko. ʻO kēia nā statins maikaʻi loa a hiki i kēia lā, a ke hopena o kā lākou hoʻohana i ke ana i ka mahina mua o ka hoʻohana mau ʻana. Ua kuhikuhi ʻia nā statins i hoʻokahi manawa i ka pō, hiki ke hoʻohui ʻia i hoʻokahi papa me nā lāʻau lapaʻau ʻē aʻe.

ʻAʻole ʻae ʻia ka hoʻohana ʻole ʻana o nā statins me ka ʻole o ka kūkā ʻana i ke kauka, no ka mea ma mua o ka lawe ʻana i ka lāʻau lapaʻau e pono ai e hoʻoholo i ke kiʻekiʻe o ka kolamu ma ke koko. Eia kekahi, inā he haʻahaʻa ka pae o ka cholesterol ma mua o 6.5 mmol / l, i loko o ʻeono mau mahina e hoʻāʻo ʻoe e hoʻohaʻahaʻa i ia me kahi meaʻai, he ola kino, a inā wale nō kēia mau hana, ʻaʻole hoʻoholo i ke kauka ma ke kau ʻana o statins.

Mai nā ʻōlelo kuhikuhi no ka hoʻohana ʻana i statins, hiki iā ʻoe ke hōʻike i nā kumu nui:

Nā hōʻailona no nā stins

ʻO ka hōʻike nui nui ʻo ka hypercholesterolemia (kiʻekiʻe cholesterol) me ka hana ʻole o ke ʻano lāʻau ʻole a me ka familial (hereditary) hypercholesterolemia me ka maikaʻi ʻole o ka ʻai.

ʻO ke kauoha ʻana i nā statins he pono no nā poʻe me ka hypercholesterolemia pili me nā maʻi e pili ana i kēia mau maʻi, ʻoiai ka hoʻohana ʻana i ka hui me nā lāʻau ʻē aʻe i kuhikuhi ʻia e ke kauka e hōʻemi nui ana i ka make o ka make cardiac make:

• ʻO nā poʻe ma luna o 40 me kahi puʻuwai kiʻekiʻe o nā maʻi cardiovascular,
• ʻO ka maʻi ʻeha Coronary, ka theina pectoris,
• Myocardial infarction
• Hoʻopuka ʻia ka hala ʻana o Aorto-coronary a i ʻole ka waiho ʻana no ka ischemia myocardial,
• ʻOkelelo
• Nā ʻilima
• Naʻi maʻi mellitus
• Nā hihia o ka make cardiac make ma waena o nā hoahānau pili ma lalo o ke 50 mau makahiki.

Hiki ke hoʻohui pū i nā statins me nā lāʻau ʻē aʻe?

Wahi a nā ʻōlelo manaʻo o ka WHO a me ka American Heart Association, ʻo nā statins he mea pono nui ia i ka mālama ʻana i ka maʻi puʻukū coronary me ka hopena kiʻekiʻe o nā hoʻopiʻi a me ka infococote myocardial. ʻAʻole i lawa nā lāʻau lapaʻau wale nō e hoʻohaʻahaʻa i ka cholesterol, no laila ke komo pū ʻia nā lāʻau lapaʻau koʻikoʻi i nā kūlana mālama - ʻo ia ka beta - blockers (bisoprolol, atenolol, metoprolol, etc.), nā mea hana antiplatelet (aspirin, aspirin Cardio, aspicor, thrombo Ass, me kekahi mea). enalapril, perindopril, quadripril, etc.) a me nā statins. Ua hoʻokele ʻia nā noiʻi ʻia i hōʻoiaʻiʻo i ka hoʻohana pono ʻana o kēia mau lāʻau i ka hui pū ʻana. Eia kekahi, me ka hui pū, no ka laʻana, pravastatin a me ka aspirin i hoʻokahi papa, ua hoʻemi nui ka pilikia o ka hoʻomohala ʻana i ka myocardial infarction (7.6%) i ka hoʻohālikelike ʻana i nā lāʻau lapaʻau wale nō (kokoke i 9% a 11% i ka wā e lawe ai i pravastatin a me aspirin, kēlā me kēia).

No laila, inā i kauoha ʻia nā statins i ka pō ma mua, ʻo ia hoʻi, i kahi manawa kaawale mai ka lawe ʻana i nā lāʻau lapaʻau ʻē aʻe, ke manaʻo nei ka poʻe kauka o ka honua i ke ʻano o ka lawe ʻana i nā lāʻau lapaʻau i loko o hoʻokahi papa. ʻO kēia mau hui hoʻohui, nā lāʻau lapaʻau i kapa ʻia i ka polypill i kēia manawa e hoʻokele nei, akā ua palena mau kā lākou hoʻohana. Ua hoʻohana maikaʻi nā lāʻau lapaʻau me ka hui pū ʻana o ka atorvastatin a me amlodipine - caduet, duplexor.

Me kahi kiʻekiʻe o ka cholesterol (ʻoi aku ma mua o 7.4 mmol / l), hiki i ka hoʻohana pū ʻana o nā statins me nā lāka i hiki ke hōʻemi ʻia mai kekahi hui e - fibrates. Pono e hana ʻia kēia koho e kahi kauka, e nānā pono ana i nā pilikia o nā hopena ʻaoʻao.

ʻAʻole hiki iā ʻoe ke hoʻohui i ka lawe ʻana i nā statins me ka waiʻala o ka huaʻala, no ka mea, he mau mea e hoʻemi ai i ka hoʻoliʻemena o nā metabolins i loko o ke kino a hoʻonui i ko lākou kūpaʻa i ke koko, i hoʻopuni ʻia me ka hoʻomohala ʻana i nā hopena ʻino kūlohelohe.

Eia hoʻi, ʻaʻole ʻoe e lawe i nā lāʻau lapaʻau me ka waiʻona, antibiotika, ma ka clarithromycin a me ka erythromycin, no ka mea hiki ke loaʻa kahi hopena o ka maʻi ma ka luhi. ʻO nā antibiotics ʻē aʻe i hui pū ʻia me nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka cholesterol ka palekana. No ka loiloi i ka hana ate, pono ia e hana i kahi hōʻike koko biochemical i kēlā me kēia mau mahina ʻekolu a hoʻoholo i ke pae o nā ate enzyme (AlAT, AsAT).

Hoʻomaʻamaʻa a maikaʻi mai - Kau a me ke Cons

Ke lawe nei i nā lāʻau lapaʻau i kuhikuhi ʻia e ke kauka, e noʻonoʻo kekahi mea maʻi e pili ana i ka pololei o nā papa hana. ʻO ka lawe ʻana i nā statins ʻaʻole nā ​​manaʻo ʻē aʻe, ma muli o kaʻoiaʻiʻo hiki iā ʻoe ke lohe pinepine e pili i ka pōʻino o kēia mau lāʻau. Hiki ke hoʻopau ʻia kēia hiʻohiʻona, ʻoiai i nā makahiki i hala ua ulu ʻia nā lāʻau lapaʻau hou e lawe mai i nā pōmaikaʻi hou aʻe i ka hōʻeha.

ʻO ke koho ma waena o ka maʻamau a me ka kumu

ʻO ka lāʻau Torvakard kekahi o nā mea hoʻokūkū koʻikoʻi o Atorvastatin.

ʻO ke kumu kūʻai ʻoi paha ka hapalua i nā mea e hoʻokō ai i nā poʻe ʻē aʻe, no ka mea, he 50% ka waihona. Ua hoʻolaha maikaʻi ʻia, loaʻa nā loiloi maikaʻi e pili ana i ia mea, no laila ke lawe nei ka poʻe iā ia me ka leʻaleʻa.

ʻOkoʻa ke ʻano o ka lāʻau i ka pauku ʻana, inā i loko o ka hana mua aia aia wale nō ka waiwai atorvastatin a me ke kōkua ma ke ʻano o ka lactose, a laila ma Torvakard he nui nā pūnao kōkua.

ʻO ka ʻano o ka lāʻau lapaʻau ka:

1. Paakai paʻakai Atorvastatin, 10 miligram - waiwai ikaika,
2. ʻO ka sodium Croscarmellose - kahi kahi momi i hāʻawi i nā wāwahi o nā papa i loko o ka ʻōpū,
3. Mālama ka lepo Magnesium i ka clumping,
4. Lactose monohala - he mea hoʻopihapiha no ka loaʻa mai ka nui o ka nui.
5. ʻO ka kūmole Monocrystalline ka ʻono a me nā ʻono ʻono,
6. ʻO ka stearate Magnesium kahi mea anti-stick i mea e hoʻomaʻamaʻa maʻalahi ai ka hana ʻana a me ka pauka.

Ka hoʻonohonoho pono ʻana o ka ʻāpana papa:

• ka titanium dioxide - he lepo minuke ma ke ʻano o ka pauma maikaʻi,
• ʻO kahi talc kahi mea e neʻe ai i ka hōʻemi ma muli o ka adsorption ma ka papa o nā grula.

E like me ka ʻike ʻana mai nā mea i hala aku nei, loaʻa i ka lāʻau lapaʻau Torvakard he mau mea ballast e hoʻonui ai i ke kaumaha a me nā mea kino. No nā hapa he nui, hoʻomohala paha ka poʻe maʻi āpau i ka intolerance a i ʻole ka hoʻouka ʻana i kahi hopena kūlohelohe, mai ka ʻalā o ka ʻeha a me ka edema Quincke, no laila ʻaʻole i ʻōlelo ʻia e hoʻohana i ka lāʻau. A i ʻole, e hana i kahi hōʻike me nā hōʻike allergenic no kēia mau pūmaka e hōʻoia ai e palekana ana ka lawe ʻana i ka lāʻau lapaʻau no ka olakino.

ʻO ka poʻe me ka intolerance lactose ua pāpā ʻia e lawe i nā ʻano āpau.

No laila he aha ka hopena ma waena o Atorvastatin a me Torvacard?

E like me ka ʻike ʻana mai nā noiʻi haumania, loiloi o ka molekule moleki pūpū a me ka pilikia alerika, ʻo Torvacard ka nui maʻa o Atorvastatin. ʻAʻole ia he mea kupanaha, no ka mea ʻo ka ʻenehana no ka hoʻokumu ʻana o ka generics e like me ka mea like, no laila ʻoi aku ka hapa o ka hopena therapeutic, a ʻoi aku ke kiʻekiʻe o ka lāʻau lapaʻau. ʻO kāna pōmaikaʻi nui ke kumukūʻai, akā pono e hoʻomanaʻo e uku ʻelua i ka mea Avaricious, a pono ʻole ʻoe e mālama i kāu olakino.

He mea kūpono paha e lawe i nā loea statins e haʻi aku i ka wikiō ma kēia ʻatikala.

• Mālama i nā pae o ke kō no ka lōʻihi
• Hoʻihoʻi hou i ka hana insulin pancreatic

Ka pōmaikaʻi o ka lawe statins

1. ʻO 40% ka hōʻemi o ka make ma ka maʻi ma nā makahiki ʻelima mua.
2. 30% ka emi ʻana o ka pilikia o ka hōʻeha a me ka puʻuwai puʻuwai,
3. Kūleʻa - hoʻohaʻahaʻa i ka cholesterol me ka hoʻohana mau ʻana e 45 - 55% o ke kiʻekiʻe kiʻekiʻe. No ka loiloi i ka hana pono, e pono i ka mea maʻi ke lawe i ka hoʻokahe koko i kēlā me kēia mahina no ka kolamu,
4. Ka palekana - ʻo ka lawe ʻana i ka hanauna hou o nā statins i ka pehu therapeutic ʻaʻole i loaʻa kahi hopena o ka nui o ke kino ma ke kino o ka mea maʻi, a he haʻahaʻa loa ka hopena o nā ʻaoʻao. Ua hōʻike ʻia kekahi mau haʻawina i hoʻokele lōʻihi i nā poʻe maʻi e lawe nei i nā statins no ka manawa lōʻihi ke hōʻike nei i ko lākou hoʻohana ʻana e hiki ai ke hoʻonāukiuki i ka hoʻomohala ʻana i ke ʻano o ka maʻi mellitus type 2, ka maʻi ʻōpū, nā cataract, a me ka hoʻoluhi noʻonoʻo. Akā, ua hōʻole ʻia a hōʻike ʻia ua ulu kēia mau maʻi ma muli o nā mea ʻē aʻe. Eia kekahi, ʻike ka ʻike ma Denmark i nā mea maʻi me ka diabetes mellitus type 2 i loaʻa i ka manawa mai 1996 e hōʻike ana i ka hiki ke hoʻomohala i ka hoʻopiʻi o nā maʻi maʻi e like me ka maʻi polyneuropathy maʻi, hoʻemi ʻia ka retinopathy e 34% a 40%.
5. ʻO kahi helu o nā mea kikoʻī me hoʻokahi mea ikaika no nā ʻano kumukūʻai like ʻole, e kōkua ana e koho i kahi lāʻau lapaʻau e pili ana i nā hiki kālā o ka mea maʻi.

Ka nele i ka lawe ʻana i nā statins

• ʻO ke kumu kūʻai nui o kekahi mau hoʻomākaukau kū mua (cross, rosucard, leskol forte). He mea mahalo, hemo maʻalahi kēia drawback i ka wā e hoʻololi ai i ka lāʻau lapaʻau me ka huahana ikaika like ʻole me ka analogue haʻahaʻa.

ʻO kaʻoiaʻiʻo, pono e lawe ʻia nā pono a me nā like ʻole e hoʻohālikelike ai i ka mea maʻi i hōʻike ʻia i ke ʻano no ka komo ʻana, inā i kānalua ʻo ia ke palekana i ka statins a kaupaona ʻia ka hoʻopiʻi a me nā kuʻuna.

Hōʻikeʻike o ka lāʻau

Hōʻike ʻia ka papa inoa o nā lāʻau lapaʻau i nā maʻi maʻi i ka papa.

ʻO ka inoa o ka lāʻau lapaʻau, ka manaʻo o ka mea kūpono (mg)

Kūʻai kumukūʻai, rub

ʻO wau ka hanauna SimvastatinVasilip (10, 20 a i ʻole 40)Keolikiia355 — 533 ʻGallelo (10, 20 a 40)Czech Republic, Israel311 — 611 Simvakard (10, 20, 40)Repubalika Czech262 — 402 Simlo (10, 20, 40)India256 — 348 Simvastatin (10, 20 a 40)Serbia, Lūkia72 — 177 PravastatinLipostat (10, 20)Lūkia, USA, Italia143 — 198 LovastatinHolla (20)Keolikiia323 Kaikuahine (20, 40)Lūkia244 — 368 II hanauna FluvastatinLeskol Forte (80)Kelemania, Sepania2315 III hanauna AtorvastatinKapukula (20)ʻO India, Rusia344 Liprimar (10, 20, 40, 80)Kelemania, USA, Irlandia727 — 1160 Kauoha (10, 40)Repubalika Czech316 — 536 Atoris (10, 20, 30, 40)Slovenia, Rusia318 — 541 Tulip (10, 20, 40)Slovenia, Suetena223 — 549 IV hanauna RosuvastatinKaikaha (5, 10, 20, 40)Lūkia, Pelekane nui, Kelemania1134 – 1600 Rosucard (10, 20, 40)Repubalika Czech1200 — 1600 Rosulip (10, 20)ʻIwaka629 – 913 Kapua (5, 10, 20)ʻIseraʻela383 – 679 PitavastatinLivazo (1, 2, 4 mg)Italia2350

ʻOiai kēlā pālahalaha pālahalaha i ke kumukūʻai o statins, nā mea ʻikole o nā meaʻala e like me ka mea haʻahaʻa loa i nā lāʻau kūʻai nui. No laila, inā hiki ʻole i ka mea maʻi ke kūʻai i ka lāʻau lapaʻau mua, hiki iā ia ke loli e like me ka mea i kuhikuhi ʻia e ke kauka me kahi mea like a me ka mea hiki ke maʻalahi.

Hiki iaʻu ke hoʻemi i kāu koloka me nā kīhāpai ʻole?

Ma ka mālama ʻana i ka atherosclerosis ma kahi hōʻike nui loa o ka kolokolo "maikaʻi" i loko o ke kino, pono ke ʻano o ka papa lāʻau mua no ka hoʻoponopono ʻana i ka nohona, no ka mea, ʻaʻole i kiʻekiʻe loa ka pae kolamu (5.0 - 6.5 mmol / l), a me ka hōʻeha ʻana o ka hōʻeha nā naʻau, hiki iā ʻoe ke hoʻāʻo. hoonui ia me ke kōkua o ia mau ʻano:

ʻO kekahi mau meaʻai i loaʻa i nā statins kūlohelohe. I waena o kēia mau huahana, ke kāleka a me ka turmeric ka mea aʻo ʻia. ʻO ka hoʻomākaukau ʻana i ka aila ʻaila i nā momona momona omega 3, kahi e kōkua ai i ka hoʻonui ʻana i ka metabolism cholesterol ma ke kino. Hiki iā ʻoe ke lawe i ka aila i kūʻai ʻia i loko o kahi kīhāpai, a i ʻole ʻoe e kuke i nā kīʻaha iʻa (trout, salmon, salmon, etc.) i kekahi mau manawa i ka pule. ʻAi ʻia ka nui o ka lau o ka lau, aia i nā huaʻai, kāloti, cereals (oatmeal, bale) a me ka legumes, he ʻoni ʻia.

Ma ka haʻalele ʻana o ka hopena o nā lāʻau lapaʻau ʻole, ke kauka nei ke kauka i kekahi o nā lāʻau lapaʻau lipid-hoʻemi.

I ka hopena, makemake wau e hoʻomaopopo i, ʻoiai nā makaʻu o nā mea maʻi a me ka manaʻo o nā pōʻino o nā statins, ua paʻa kā lākou kumu no ka lōʻihi o ka atherosclerosis me ka hōʻino i ka pili o nā coronary, no ka mea e hoʻolōʻihi nei kēia mau lāʻau i ke ola. Inā he kolamu nui ko ʻoe me ka ʻole o nā hōʻailona mua o ka pōʻino o ka vascular, a laila pono ʻoe e ʻai pono, neʻe ikaika, alakaʻi i kahi ola olakino, a ma ka wā e hiki mai ʻole ʻoe e noʻonoʻo e pili ana i ka lawe ʻana i nā statins.

Hiki ke lawe i nā papa ʻo Atoris no ka manawa lōʻihi?

ʻAe, hoʻolālāʻia nā statins a pau i kahi huakaʻi lōʻihi (e komo pū ana me ke ola). Ināʻo ia i kahi maʻi maʻi maʻalahi e hōʻemi i ka cholesterol a ʻaʻole i kumu e hoʻonui i ka ALT a me AST (nā enzymes i loko o nā hoʻāʻo ʻana i ke koko), hiki iā ʻoe ke hoʻomau i ka lawe. Eia kekahi, hoʻokahi i kēlā me kēia mahina 6, pono ʻoe e hoʻomaʻi i ka hoʻokahe koko no ka 'lipid profile (cholesterol), ALT, AST.

Vitio: pono anei ia e lawe i statins?

ʻEkau 2: ma hope o ka uku ʻana, nīnau i kāu nīnau ma ke pepa ma lalo ↓ ↓ 3: Hiki hiki iā ʻoe ke hoʻomaikaʻi hou i ka mea loea me ka uku ʻē aʻe no ka uku uku.

ʻO nā lāʻau lapaʻau kiʻekiʻe Swiss e hiki ke hōʻemi i ka LDL e 50%, a me ka cholesterol - e ka 40%. Hoʻomaopopo ka hopena i nā 3 wiki ma hope o ka noi, a me ka hopena o ka hopena ma hope o hoʻokahi mahina.

Hoʻomaka ka hoʻolālā ma kahi liʻiliʻi o 10 mg o ka mea ikaika i kēlā me kēia lā, inā pono e hoʻonui nui ʻia ma hope o nā hebedoma 3-4, e pili ana i ka nānā ʻana o nā helu koko. E like me nā statins ʻē aʻe, loaʻa ka maʻi i nā hopena ʻaoʻao e like me ka insomnia, kahi heterogeneous, a me ka nāwaliwali o ka naʻau. Hoʻomaka nā kumukūʻai no Swiss Tulip mai 255 mau rubles no nā papa 30 no ka nui o ka 10 mg.

ʻO ka hoʻonaninani hou a me nā kumu maʻalahi loa no Atoris mai ka mea hana Lūkia ʻo ATOLL. Loaʻa ia i ke ʻano o nā capsules a loaʻa i kekahi mau mea kōkua o ke kōkua, e hiki ai iā ʻoe ke hoʻokō i kahi hopena wikiwiki hou aʻe i ka hopena o ka lāʻau.

Ke mau nei ka palena ma mua - 10 mg / lā. Eia nō naʻe, ma mua o ka hoʻohana ʻana i ka lāʻau lapaʻau, ʻoi aku ia i ka huli ʻana i ke ʻano hypocholesterol maʻamau, pono e nānā ʻia i ka wā holoʻokoʻa. Hoʻomaka nā kumukūʻai no ka novostatin mai 330 mau rubles.

ʻAʻole maʻalahi maʻalahi, akā palekana loa a ʻoi aku ka maikaʻi, me ka liʻiliʻi loa o nā hopena ʻāpana, ʻo ka Ireland. I ka ʻoiaʻiʻo, ʻo ia ka mea like me ka hypolipidemic a me ka hypocholesterolemic o ka lāʻau lapaʻau Pfizer ʻoihana, i ʻike ʻia no kona ʻenehana kiʻekiʻe kiʻekiʻe a me ka hoʻohana ʻana i nā mea hoʻohui like e like me ka mea i hiki ke hoʻomālamalama ʻia o ke kino, ka mea nui no ka hoʻomohala ʻana i ka wā lōʻihi. I ka hihia o ka cholesterol kiʻekiʻe, hiki i ka mālama statin ke mau loa mai kekahi mau mahina a oi i hoʻokahi makahiki.

I ka manawa like, aia kahi hemahema o kēia hoʻomākaukau, ʻo ia kona uku kiʻekiʻe. Hoʻomaka nā kumukūʻai no Liprimar i nā lāʻau lapaʻau ma Rusia ma ka 700 rubles no 10 papa o ka palena liʻiliʻi.

Eia nō hoʻi, hiki ke hoʻopihapiha ʻia nā papa inoa o nā mea waiwai ʻo Atoris haʻahaʻa me nā lāʻau lapaʻau i ʻike ʻole ʻia ʻia, akā i kēia manawa i ka mākeke, e like me: Ator, Atomax, Amvastan, Lipoford, Torvalip, Torvas. He mea nui e hoʻomanaʻo e pili ana i nā contraindications, nā mea no nā lāʻau lapaʻau a pau i luna.

Palena Mokuna Hoʻohālikelike Mokuna

ʻO nā hōʻiliʻili o kekahi lāʻau lapaʻau nā lāʻau kūlohelohe o nā wā kahiko. Koi aku ka poʻe heluhelu ʻO ka hoʻōla kūlohelohe, kahi i hui pū me ka meaʻai a me nā hana, hoʻemi nui ʻia ka kolamu ma hope o 3-4 pule . ʻO ka manaʻo o nā kauka >>

He mea ʻole o ka mea hana a me ka ʻaki, ʻo nā lāʻau āpau o luna e pili ana i ka atorvastatin a hana like like (me ka ʻokoʻa ʻole o nā ʻokoʻa ʻē aʻe o nā hopena hoʻopiʻi, ka palekana a me ka wikiwiki o ka komo ʻana i ke koko) - he mea ʻoiaʻiʻo kēia.

ʻO kēlā mau ʻano ʻokoʻa i ka uku e hiki ke wehewehe ʻia e ke kumukūʻai o ka hana (ʻo ke ʻano o ka uku o nā limahana, nā kumukūʻai) Eia nō naʻe, manaʻoʻiʻo ia e hoʻohana nā ʻoihana nui a me nā ʻoihana ʻē aʻe i nā mea hana hou o kēia mau mea a hoʻonoho i nā koi kiʻekiʻe no ka hana ʻana, ma muli o kahi e loaʻa ai kahi huahana maikaʻi.

Wahi a ke kaʻe o 10 mg / lā, e lawa loa kahi pāpana he 30 no ka malama o ka mālama ʻana. Inā, ma hope o ka malama mua o ka mālama ʻana, kaukaʻi nā kauka i kahi papa statin i oi aku ma mua o 2 mau mahina, ʻoi aku ka maikaʻi o ke kūʻai ʻana mai i kahi papa o nā papaʻaina o 90 a 100 paha, no ka mea ʻoi ke kumukūʻai o hoʻokahi papa i nā pahu nui.

Ka hana lāʻau lapaʻau

ʻO ka lipid-liping Synthetic lāʻau. ʻO Atorvastatin he mea mālama i ka hoʻokūkū koho o ka HMG-CoA reductase, he kīme nui e hoʻohuli ana i ka 3-hydroxy-3-methylglutaryl-CoA i mevalonate, kahi mea i mua i ka lāʻau, a me ka kolamu.

I ka poʻe maʻi me ka homozygous a heterozygous familial hypercholesterolemia, non-familial form of hypercholesterolemia and mixed dyslipidemia, atorvastatin lowers total cholesterol (Ch) in plasma, cholesterol-LDL a me apolipoprotein B (apo-B), a e hoʻolauna pū iā TG-C a me TG ka hoʻonui pinepine ʻole ma ka pae o HDL-C.

Hoʻopili ke Atorvastatin i ka hoʻoneʻe ʻana o ka kolamu a me nā lipoproteins i loko o ke koko koko, e hoʻoneʻe ana i ka hoʻōla ʻana o HMG-CoA a me ka synthesis o ka kolamu o ka ate a me ka hoʻonui ʻana i ka nui o nā mea hoʻokipa LDL hepatic ma luna o ka pūlaka, kahi e hoʻonui ai i ka hoʻonui a me ka catabolism o LDL-C.

Hoʻopili ke Atorvastatin i ka hoʻokumuʻana o LDL-C a me ka nui o nā māhele LDL. Hoʻokumu ia i ka hoʻonui i hoʻomau a hoʻomau i ka hana o nā mea LDL e komo pū ai, a hui pū me nā loli qualitative maikaʻi loa i nā hapa LDL. Hoʻēmi i ka pae o ka LDL-C i nā mea maʻi me ka hypercholesterolemia homozygous me ka pale ʻana i ka lāʻau lapaʻau me nā lāʻau lapaʻau ʻē aʻe.

Nā Atorvastatin i nā inane o ka mg e hōʻemi ana i ka kolamu holoʻokoʻa ma ka 30-46%, LDL-C e 41-61%, apo-B e 34-50% a me TG e 14-33%. Hoʻohālike nā hopena lapaʻau i nā mea maʻi me ka heterzygous famamial hypercholesterolemia, ʻaʻohe ʻohana ʻohana o hypercholesterolemia a me ka hyperlipidemia i hui pū ʻia, me ka komo pū i nā mea maʻi me ka diabetes-mellitus-non-diabetes mellitus.

I nā maʻi me ka hypertriglyceridemia hoʻokaʻawale, hōʻemi loa ʻo atorvastatin i ka kolamu a pau, Chs-LDL, Chs-VLDL, apo-B a me TG a hoʻonui i ke kiʻekiʻe o Chs-HDL. I nā maʻi me ka dysbetalipoproteinemia, e hōʻemi ana i ka pae o ChS-STD.

I ka poʻe maʻi me ka type IIa a me IIb hyperlipoproteinemia e like me ka helu ʻana o Fredrickson, ʻo ka nui o ka piʻi ʻana o ka hoʻonui ʻana o HDL-C i ka wā mālama me ka atorvastatin (10-80 mg), i hoʻohālikelike ʻia me ka waiwai mua, ʻo ia ka 5.1-8.7% a ʻaʻole i hilinaʻi ma ka ʻōlelo. Aia ka nui o ka hoʻoliʻiliʻi a hilinaʻi nui i ka pae: ʻo ka kolamu piha / Chs-HDL a me Chs-LDL / Chs-HDL e ka 29-44% a me 37-55%, ia manawa.

ʻO Atorvastatin ma kahi o 80 mg ka hoʻohaʻahaʻa nui loa i ka hōʻemi o ka hoʻopiʻi ischemic a me ka make e 16% ma hope o kahi papa 16 wiki, a me ka hopena o ka hoʻoliʻi hou ʻana no ka angina pectoris, i hui pū ʻia e nā hōʻailona o ka ischemia myocardial, e 26%. I nā mea maʻi me nā pae baseline like ʻole o ka LDL-C, hiki i ka atorvastatin ka hopena o ka hōʻemi o ka hoʻopiʻi ischemic a me ka make (i nā mea maʻi me ka myocardial infarction me ka hawewe Q a me ka pupule mau ʻole, nā kāne a me nā wahine, nā mea maʻi ma lalo o 65 mau makahiki).

Loaʻa ka hopena therapeutic i 2 mau pule ma hope o ka hoʻomaka ʻana o ka hōʻola, a hiki i ka nui loa ma hope o 4 mau hebedoma a hoʻomau i ka holoʻokoʻa o ka wā mālama.

Kāohi pilikia Cardiovascular

I ka noi ʻana o Anglo-Scandinavian o ka hopena o ka hopena cardiac, ka lālā lipid-hina i haʻahaʻa (ASCOT-LLA), ua ʻike ʻia ka hopena o ka atorvastatin ma ka maʻi paloka a me ka mea make i loko o ka puʻuwai, ʻike ʻia ka hopena o ka hopena o ka hopena atorvastatin ma ke ʻano o 10 mg nui i hoʻonui ʻia i ka hopena o ka plasebo, a no laila ua hoʻoholo ʻia. nā haʻawina ma hope o 3.3 mau makahiki ma mua o ka manaʻo he 5 mau makahiki.

Ua hoʻemi nui ʻia ʻo Atorvastatin i ka hoʻomohala ʻana o nā hoʻopiʻi hou aʻe nei:

ʻAʻole i emi ka nui o ka make a me ka make ma hope o ka make, ʻoiai ua mālama ʻia nā ʻano kūpono.

I ka hui pū ʻana o ka hopena o ka atorvastatin i nā mea maʻi me ka maʻi diabetes mellitus type 2 (CARDS) i ka hopena hōʻeha a me ka mea ʻole ke make o nā maʻi cardiovascular, hōʻike ʻia ʻo ia ka mālama ʻana me ka atorvastatin, ka manaʻo ʻole o ke kāne maʻi, ʻokoʻa, a i ʻole pae o LDL-C, hoʻemi i ka pilikia o ka hoʻomohala ʻana i nā maʻi cardiovascular e hiki mai ana. :

I loko o ka noiʻi ʻana i ka hoʻomohala ʻana o ka atherosclerosis coronary me ka ʻeha hypolipidemic therapy (REVERSAL) me ka atorvastatin ma kahi pākēpē o 80 mg i nā mea maʻi me ka maʻi ʻalihi coronary, ʻike ʻia ka nui o ka hoʻemi ʻana o ka nui o ka atheroma (ka hapa mua o ka hoʻomaʻamaʻa) mai ka hoʻomaka ʻana o ka noi ʻana he 0.4%.

Ma ka Intensive Cholesterol Reduction Program (SPARCL) ʻike i ka atorvastatin ma ke ʻano o 80 mg i kēlā me kēia lā i hōʻemi ʻia ka hopena o ka hōʻeha hou ʻana a i ʻole ka make i ka maʻi maʻi i loaʻa i ka moʻolelo o ka hōʻeha a i ʻole ka maʻi ischemic attack me ka ischemic heart heart e ka 15%, i hoʻohālikelike ʻia me ka placebo. I ka manawa like, ua hoʻemi nui ʻia ka loaʻa ʻana o ka hōʻeha o nā ʻōkuhi a me ka hōʻola hou aku i nā loiloi. ʻO ka hōʻemi ʻana i ka hopena o ka maʻi cardiovascular i ka wā o ka lapaʻau me ka atorvastatin i nānā ʻia i loko o nā hui āpau koe wale nō ka mea i komo i nā mea maʻi me ka maʻi hemorrhagic mua a i ʻole (7 i ka hui atorvastatin ma 2 i ka hui pletebo).

I loko o nā mea maʻi i mālama ʻia me ka hopena atorvastatin ma ke ʻano o 80 mg, i ka loaʻa ʻana o ka hemorrhagic a i ʻole ischemic stroke (265 ma mua o 311) a i ʻole IHD (123 kūmole 204) ka liʻiliʻi ma mua o ka pūʻulu mana.

Kākoʻo pale ʻelua o nā pilikia hoʻonā

Ma nā ʻōlelo o ka New Target Study (TNT), ua hoʻohālikelike ʻia nā hopena o ka atorvastatin ma nā kikowaena o 80 mg i kēlā me kēia lā a me 10 mg i kēlā me kēia lā ma ka pilikia o ka hoʻomohala ʻana i nā hoʻopiʻi cardiovascular ma nā maʻi me ka maʻi neʻeneʻi i nā maʻi maʻi coronary i hoʻohālikelike ʻia.

Atorvastatin ma ke ʻano o 80 mg hoʻohaʻahaʻa nui ʻia ka hoʻomohala ʻana o kēia mau ʻōlelo hoʻopiʻi:

ʻO nā kikowaena e pili ana i ka rosuvastatin - kekahi mea ikaika

No nā poʻe o nā poʻe e pili ana i nā pae a me nā nui ma ka laulā. Eia nō naʻe, i kēia lā ua kū ka hanauna ʻehā, kahi e lilo nui ana i mea kaulana a hiki i ka wā e hiki mai ana, ke hoʻohuli maoli nei i ka kolu.

ʻO ka mea hoʻonaninani ka rosuvastatin. Mahalo iā ia, ʻoiai me ka uku ʻai o kēlā me kēia lā he 5 mg, hiki ke hoʻokō ka mea like, a ma kekahi mau hihia, ʻo ka wikiwiki ka hopena. ʻOiaʻiʻo, loaʻa ke ʻano haʻahaʻa haʻahaʻa i ka palupalu i ka palupalu, hoʻopiʻi i nā hopena liʻiliʻi, ʻoi aku ka ʻike maʻamau me ka mālama lōʻihi.

Akā, e makaʻala, no ka mea ʻo ke ʻano o nā hanauna ʻelua o nā lāʻau ke neʻe nei i ka hoʻohaʻahaʻa i ka hoʻoulu kolesterol a kūpono ia i nā poʻe maʻi me ka hypocholesterolemia, he ʻano iki ko lākou kumu o ka hana ma ke ʻano, he hopena ʻaʻole wale nō ka hopena o ka mālama ʻana, akā ʻo ka mokuʻāina hoʻi o nā lehulehu kino.

Manaʻo paha ʻoe he hiki ʻole ke hōʻalo ʻia ke kō koko kiʻekiʻe?

ʻO ka hoʻoholo ʻana ma ka ʻoiaʻiʻo e heluhelu nei ʻoe i kēia mau laina - ke pilikia paha ka pilikia o ke kolamu kiʻekiʻe iā ʻoe. Akā ʻaʻole kēia mau laka: ʻaʻole i hoʻokaumaha nui ka laha ʻana i ke koko a, inā ʻaʻole i hana ʻia, hiki ke hoʻopau i ka hopena kaumaha loa.

Akā he mea nui e hoʻomaopopo e pono ia i ka mālama ʻana ʻaʻole i nā hopena i loko o ke ʻano o ke kōpana a i ʻole ka hoʻomanaʻo ʻana, akā ʻo ke kumu. Malia paha ʻoe e hoʻomaʻamaʻa iā ʻoe iho me nā pono hana a pau ma ka mākeke, ʻaʻole naʻe hoʻolaha ʻia? ʻOiaʻiʻo, maʻamau i ka wā e hoʻohana ai i ka hoʻomākaukau ʻana i nā mea kemika me nā hopena ʻaoʻao, ua loaʻa kahi hopena i kapa ʻia kahi mea "kaulana aʻi kekahi, ʻo nā mea maʻi āpau". I kekahi o kāna mau papahana, ua pā aku ʻo Elena Malysheva i ke kumuhana o ka cholesterol kiʻekiʻe a ua kamaʻilio e pili ana i kahi lāʻau lapaʻau i hana ʻia mai nā mea kanu lāʻau kūlohelohe ...

Lapaʻau lāʻau

Hoʻopili koke ʻia ʻo Atorvastatin ma hope o ka lawelawe ʻana o ka waha, ua loaʻa ʻo Cmax ma hope o nā hola 1-2. ʻO ka pae o ke kūpaʻa a me ka hoʻokipa ʻana o ka atorvastatin i ka plasma koko hoʻonui i ka nui o ka pākīpī. ʻO ka bioavailability piha o atorvastatin ma kahi o 14%, a me ka bioavailability o ka ʻōnaehana o ka hana pale ma ka HMG-CoA reductase ma kahi o 30%. ʻO ka bioavailability haʻahaʻa haʻahaʻa ma muli o ka metabolism presystemic i ka mucosa gastrointestinal a me / a i ka wā o ka "ʻōlelo mua" ma o ka ate. Hōʻemi ka meaʻai i ka nui o ka nui a me ka nui o ka inu ʻana ma kahi o 25% a me 9%, kēlā, e like me ka hōʻike ʻia e nā hopena o ka hopena o Cmax a me AUC), akā ke kiʻekiʻe o ka LDL-C i ka wā e lawe ana i ka atorvastatin ma kahi ʻōpū ʻole a ma ka wā ʻaina e emi ma lalo o ka like. ʻOiai ka mea ma hope o ka lawe ʻana i ka atorvastatin i ke ahiahi, ua emi iho kona pae plasma (Cmax a me AUC ma kahi o 30%) ma hope o ka lawe ʻana i kakahiaka, akā, ʻaʻole ka hilinaʻi ka hōʻemi ma LDL-C i ka manawa o ka lā e lawe ʻia ai ka lāʻau.

ʻO ka awelika Vd o atorvastatin he 381 lita. ʻO ka paa ʻana o ka atorvastatin i nā protein plasma ma kahi o 98%. ʻO ka ʻike o ka pae o ka atorvastatin ma loko o nā kaila koko / koko plasma ma kahi o 0.25, i.e. ʻaʻole komo ʻo atorvastatin i nā ʻāpana koko ʻaʻī.

Hoʻohā nui ʻia ka Atorvastatin e hana i nā derivatives ortho- a para para-hydroxylated a me nā huahana beta-oxidation. In vitro, ortho- a me para-hydroxylated metabolites he hopena pale i ka HMG-CoA reductase, i hoʻohālikelike ʻia i ka atorvastatin. ʻO ka hana pale i ka HMG-CoA reductase ma kahi o 70% ma muli o ka hana o nā neʻe ʻana i nā metabolites. I loko o nā haʻawina vitro hōʻike ana i ka isoenzyme CYP3A4 hana koʻikoʻi i ka hana o ka metabolism o atorvastatin. Ua hōʻoia ʻia kēia e ka piʻi ʻana o ka mea i atorvastatin i loko o ke koko koko o ke kanaka i ka wā e lawe ana i ka erythromycin, ʻo ia ka mea e hoʻomehana ai i kēia isoenzyme.

Ua hōʻike pū ʻia nā haʻawina vitro he atorvastatin kahi mea palupalu ikaika o ka isoenzyme CYP3A4. ʻAʻohe hopena koʻikoʻi ʻo Atorvastatin i ka paʻa ʻana o ka terfenadine i ka plasma, ka mea i ʻike nui ʻia e ka isoenzyme CYP3A4, i kēia mea, i ka hopena nui o ka atorvastatin ma ka pharmacokinetics o nā mea hou aʻe o ka isoenzyme CYP3A4 i like ʻole.

Hoʻokomo ʻia ʻo Atorvastatin a me kāna mau metabolite me ka bile ma hope o ka hepatic a / a i ʻole metabolism nui aʻe (atorvastatin ʻaʻole i pau i ka hoʻolika ʻana o ka enterohepatic). Ma kahi o 14 mau hola he T1 / 2, ʻoiai ka hopena o ka hopena o ka lāʻau e pili ana i ka HMG-CoA reductase ma kahi o 70% e hoʻoholo ana e ka hana o nā metabolites i kahakaha a mālama ʻia ke apo ma muli o ko lākou heleʻana. Ma hope o ka lawelawe waha, ua emi iho ma lalo o 2% o ka make o ka atorvastatin e ʻike ʻia i ka urin.

ʻO ka pharmacokinetics i nā hihia lapaʻau kūikawā

ʻO ke kaila o ka plasma o ka atorvastatin i nā ʻelemakule (mau makahiki he 65 mau makahiki) ʻoi aku ka nui (Cmax ma kahi o 40%, AUC ma kahi o 30%) ma mua o nā maʻi maʻi o nā makahiki ʻōpio. ʻAʻohe ʻokoʻa nā ka palekana, ka hopena, a me ka hoʻokō ʻana i nā pahuhopu o ka hoʻomaʻamaʻa ʻana o lipid-hoʻohiolo i ka poʻe ʻelemakule i hoʻohālikelike ʻia me ka lehulehu.

ʻAʻohe hana i hōʻike ʻia i ka pharmacokinetics o ka lāʻau i nā keiki.

Nā ʻokoʻa o nā pehu o ka atorvastatin i nā wahine (Cmax ma kahi o 20% kiʻekiʻe, a ʻo AUC ma ka 10% mau haʻahaʻa) mai kēlā mau kāne.Eia nō naʻe, ʻaʻole i ʻike ʻia nā ʻokoʻa koʻikoʻi o nā maʻi i ka hopena o ka lāʻau ma ka lipid metabolism i nā kāne a me nā wahine.

Hoʻopilikia i ka hana renal pale i ka hoʻopili ʻana i ka atorvastatin i loko o ke kaila koko a i kona hopena ma nā lipid metabolism. Ma kēia noʻonoʻo, ʻaʻole pono ka loli ʻana o nā maʻi maʻi i nā mea maʻi me nā hana renal impaired.

ʻAʻole i hoʻoiho ʻia ʻo Atorvastatin i ka wā hemodialysis ma muli o kahi paʻa paʻa i ka protein plasma.

Ua hoʻonui nui ʻia nā kukuna Atorvastatin (Cmax a me AUC ma kahi o 16 a me 11 mau manawa, kēlā) i nā mea maʻi me ka cirrhosis alkohol (papa B ma ka pēpē ʻAno-Pugh).

Nā hōʻailona no ka hoʻohana ʻana i ka lāʻau LIPRIMAR®

• hypercholesterolemia maʻamau (heterozygous familial a non-familial hypercholesterolemia (type IIa e like me ka helu o Fredrickson),
• hui ia (hui pū ʻia) hyperlipidemia (nā ʻano IIa a me IIb e like me ka helu ʻana o Fredrickson).
• dibetalipoproteinemia (type III e like me ka helu ʻana o Fredrickson) (me ka hoʻohui o ka ʻai)
• hypertriglyceridemia familial (ʻano IV ma muli o ka helu ʻana o Fredrickson), kū i kaʻai,
• homozygous famchial hypercholesterolemia me ka lawa ʻole o ka hana o kaʻai ʻana i ka papa ʻaina a me nā ʻano ʻē aʻe non-pharmacological o ka maʻi.
• ka pale mua ʻana o nā hoʻopiʻi cardiovascular ma nā mea maʻi me nā hōʻailona ʻole o ka maʻi coronary heart disease, akā me kekahi mau mea pili i ka ulu ʻana - ʻoi aku ka makahiki ma mua o 55 mau makahiki, ka hoʻohui ʻana ʻo nikotine, hypertension arterial, diabetes mellitus, nā haʻahaʻa haʻahaʻa o HDL-C i ka plasma, predisposition genetic, etc. hola e kū'ē ana i ka mua o ka dyslipidemia,
• pale aku i ka lua o nā hoʻopiʻi cardiovascular ma nā mea maʻi me ka maʻi puʻuwai coronary e hōʻemi i ka nui o ka make me ka nui, myocardial infarction, stroke, re-hospitalization no angina pectoris a me ka pono no ka revascularization.

ʻLoe a me ke kākele

Ma mua o ka hoʻomaka ʻana i ka mālama ʻana me Liprimar, pono e hoʻāʻo e hoʻokō i ka hoʻopulapula o ka hypercholesterolemia ma o kaʻaiʻai, ka hoʻomaʻamaʻa ʻana a me ka hoʻohaʻemi ʻana o ka maʻi i nā mea maʻi me ka momona, me ka mālama ʻana i ka maʻi ma lalo.

Ke hoʻoholo nei i ka lāʻau lapaʻau, pono ke hoʻomau i ka mea maʻi i kahi meaʻai hypocholesterolemic maʻamau, pono ia e hahai i ka wā o ka mālama ʻana.

Lawe ʻia ka lāʻau lapaʻau i kēlā me kēia manawa o ka lā, me ke ʻano o ka komo ʻana o ka meaʻai. Hoʻololi ʻia ka ʻano o ka lāʻau lapaʻau mai 10 mg a 80 mg i hoʻokahi manawa i ka lā, e lawe ʻia ke koho o ka ʻikepili me ka noʻonoʻo ʻana i nā pae mua o ka LDL-C, ke kumu o ka hoʻomohala a me ka hopena pilikino. ʻO ka dosis kiʻekiʻe loa he 80 mg hoʻokahi i ka lā.

I ka hoʻomaka ʻana o ka hoʻōla a me / a ʻoiai e hoʻonui ana i ka nui o ka make o Liprimar, pono ia e nānā i ka hāpau lipid plasma ma kēlā me kēia mau hebedoma 2-4 a e hoʻoponopono pono i kēia ʻano.

No ka hypercholesterolemia mua a hoʻohui ʻia (kāwili ʻia) hyperlipidemia no ka hapanui o nā maʻi, ʻo ka nui o Liprimar e 10 mg hoʻokahi i ka lā. Hōʻike ʻia ka hopena therapeutic i loko o 2 mau pule a hiki i ka lōʻihi ma waena o 4 mau pule. Me ka lōʻihi o ka mālama ʻana, hoʻomau ka hopena.

Me ka hypercholesterolemia famerial homozygous, ua kauoha ʻia ka lāʻau lapaʻau ma loko o kahi pānaʻi o 80 mg hoʻokahi i ka lā. (ka hoʻemi ma ka pae o LDL-C e ka 18-45%).

I ka hihia o ka huni o ka ate, pono e hoʻemi ʻia ka nui o ka liprimar ma lalo o ka kaohi mau o ka hana a ACT a me ALT.

ʻAʻole pili ka hana o ka renal i ka pale ʻana i ka ʻike o ka atorvastatin i loko o ke kaila koko a i ʻole ka pae o ka hōʻemi i loko o ka ʻike o LDL-C i ka wā e hoʻohana ai i Liprimar, no laila, ʻaʻole pono ka hoʻoponopono ʻana o ka lāʻau.

I ka wā e hoʻohana ai i ka lāʻau lapaʻau i nā maʻi maʻi ʻelemakule, ʻaʻohe ʻokoʻa ʻole o ka palekana, pono ka hoʻohālikelike ʻia me ka lehulehu kanaka, ʻaʻole pono ka hoʻoponopono ʻana o ka dosis.

Inā pono ka hana like me ka cyclosporine, ʻaʻole pono ka nui o ka liprimar® i ka 10 mg.

10 mau makahiki weliweli = 160

* Hōʻike kekahi mau loea e hoʻohana i ka hoʻohana ʻana i nā lāʻau palaka lipid e hōʻemi ana i ka ʻike o LDL-C inā ʻaʻole ka hopena o ke ʻano i ka hana i ka emi ʻana o kona manaʻo i ka pae o nā ʻōlelo aʻo no ka hoʻohana ʻana i nā lāʻau lapaʻau.

Hāʻawi ʻia i ka ʻoiaʻiʻo e pili ana ka atherosclerosis, he mea kūpono ia e hoʻokokoke me ke kuleana me ka kuleana. He paʻiʻo statine ke gula no ka maʻi.

ʻO ka hana o kā lākou hana ka mea like no ka hui holoʻokoʻa a paʻa i ka blockade o nā enzymes redmase HMG-CoA e kāpae i ka kolamu ma ka puʻuwai.

ʻO ke kumu kūʻai ʻoi paha ka hapalua i nā mea e hoʻokō ai i nā poʻe ʻē aʻe, no ka mea, he 50% ka waihona. Ua hoʻolaha maikaʻi ʻia, loaʻa nā loiloi maikaʻi e pili ana i ia mea, no laila ke lawe nei ka poʻe iā ia me ka leʻaleʻa.

ʻOkoʻa ke ʻano o ka lāʻau i ka pauku ʻana, inā i loko o ka hana mua aia aia wale nō ka waiwai atorvastatin a me ke kōkua ma ke ʻano o ka lactose, a laila ma Torvakard he nui nā pūnao kōkua.

ʻO ka ʻano o ka lāʻau lapaʻau ka:

1. Paakai paʻakai Atorvastatin, 10 miligram - waiwai ikaika,
2. ʻO ka sodium Croscarmellose - kahi kahi momi i hāʻawi i nā wāwahi o nā papa i loko o ka ʻōpū,
3. Mālama ka lepo Magnesium i ka clumping,
4. Lactose monohala - he mea hoʻopihapiha no ka loaʻa mai ka nui o ka nui.
5. ʻO ka kūmole Monocrystalline ka ʻono a me nā ʻono ʻono,
6. ʻO ka stearate Magnesium kahi mea anti-stick i mea e hoʻomaʻamaʻa maʻalahi ai ka hana ʻana a me ka pauka.

Ka hoʻonohonoho pono ʻana o ka ʻāpana papa:

• ka titanium dioxide - he lepo minuke ma ke ʻano o ka pauma maikaʻi,
• ʻO kahi talc kahi mea e neʻe ai i ka hōʻemi ma muli o ka adsorption ma ka papa o nā grula.

E like me ka ʻike ʻana mai nā mea i hala aku nei, loaʻa i ka lāʻau lapaʻau Torvakard he mau mea ballast e hoʻonui ai i ke kaumaha a me nā mea kino. No nā hapa he nui, hoʻomohala paha ka poʻe maʻi āpau i ka intolerance a i ʻole ka hoʻouka ʻana i kahi hopena kūlohelohe, mai ka ʻalā o ka ʻeha a me ka edema Quincke, no laila ʻaʻole i ʻōlelo ʻia e hoʻohana i ka lāʻau. A i ʻole, e hana i kahi hōʻike me nā hōʻike allergenic no kēia mau pūmaka e hōʻoia ai e palekana ana ka lawe ʻana i ka lāʻau lapaʻau no ka olakino.