ʻO ka Proinsulin kahi mea i mua o ka insulin, i hana ʻia e nā hua beta o ka pancreas a hoʻoponopono i ka kaila koko. Hōʻemi ka emi ʻana o ka pālahalaha proinsulin e nānā ʻia ana i ke ʻano type mellitus type 1 (kahi maʻi endocrinological i hōʻike ʻia e ka nui o ke kōpaʻa koko i ke kiʻekiʻe o ke ʻano o ka hana i mea e hana ʻia ai ka insulin).

ʻO kahi huliʻana o ka ʻike o ka proinsulin i ke koko ka mea e hiki ai ke hōʻike i nā ala o nā cell beta o nā mokupuni o Langerhans me ke kūpaʻa kiʻekiʻe, i.e. diabetes mellitus, me ka hopena o ka manawa pono i ka hoʻomohala ʻana o ka moku prediabetic a me ka insulinoma (endocrine tumor huna huna i ka insulin).

Hoʻopili ʻia nā Proinsulin ma loko o nā pū beta o ka pancreas i loko o nā poli secretory. I loko o lākou, ma lalo o ka mana o ka PC1 / 3, PC2 a me ka carboxypeptidase E prohormones, hemo ia i ka insulin a me C-peptide. ʻO ka 3% wale nō o ka proinsulin e hoʻopaʻa ʻole i nā hormone a e hoʻopolo i ka ʻano manuahi. Eia nō naʻe, hiki i ka paʻa ʻana i ke koko ke hiki i ka 10-30% o ka nui o ka hoʻopuni i ka insulin, ʻoiai ʻo ka hapalua o ka ola o ka proinsulin he 3 mau manawa o ka lōʻihi.

Kākau: nā hana proinsulin he 10 mau manawa ma mua o ka insulin. Akā me kēia, ka piʻi ʻana o kona neʻe i loko o ke koko e hiki ai i kahi kūlana hypoglycemic (kahi hōʻemi koʻikoʻi i ke kō koko koko). Hoʻonui ka hoʻonui i nā pae proinsulin e hōʻike i nā pilikia me nā keiki (ka hemahema, nā hana), ke akeʻa (cirrhosis), gland thyroid (hyperthyroidism), etc.

Hiki ke hoʻonui ʻia ka nui o ka proinsulin koko ma hope o ka ʻai ʻana, a i ka wā mua i ka maʻi maʻi. ʻO ke kaohi ʻana o ka proinsulin kekahi ʻano ʻano o nā hana kalignant (kahiʻano o nā pūlima islet e huna nei i ka insulin).

Ma nā hihia liʻiliʻi, piʻi i ka ʻike ʻana o ka proinsulin me ka hoʻopiʻi ʻole o ka hoʻopulapula PC1 / 3, ka hoʻouka ʻana o ka ʻōnaehana endocrine. Ke alakaʻi nei kēia kulekele i kahi hana hoʻohālikelike i ka hana ʻana o nā hormone peptide, e kū'ē i kēlā mehe nui, maʻi, ka maʻi a me ka maʻi diabetes.

ʻO ka mea mahalo, ʻo ka hapa nui o nā mea maʻi me ka pio hoʻololi e loaʻa i ka lauoho ʻulaʻula, e like me ka makahiki, ke kāne a me ka lāhui.

Nā hōʻailona no ka hoʻoili

Hōʻike ʻia ka hōʻike ʻo proinsulin i kēia mau pilikia:

• nā kūlana hypoglycemic, me nā mea i hoʻokahua ulu ʻana
• ka maʻi ʻana o nā neoplasms pancreatic (insulinoma),
• ka loiloi o ka ʻōnaehana a me ka hana o nā ʻāpana beta o islet,
• ka hoʻoholo ʻana o ka hoʻoweliweli hoʻololi a me nā ʻano like ʻole o ka molime o ka molina proinsulin,
• kahi hoʻohālikelike o ka maʻi maʻi.

Hiki ke hoʻopiʻi ʻia nā hopena o nā hoʻokolohua proinsulin e kahi mea lapaʻau, oncologist, endocrinologist, gynecologist a me ka lāʻau lapaʻau.

ʻO keʻano o ka proinsulin

ʻO ka pae ʻai maʻamau no kahi hoʻokolohua proinsulin plasma he pmol no 1 pā o ke koko.

17 mau makahiki0,7 – 4,3

Kākau: ʻO nā waiwai hōʻike i hāʻawi ʻia he kūpono wale no nā hoʻokolokolo i hana ʻia ma kahi ʻōpū ʻole.

Hoʻonui nā kumukūʻai

• Ka mōʻaukala o ka hyperproinsulinemia (kahi kūlana o ka proinsulin i hoʻokiʻekiʻe ʻia i ka maʻi mellitus a i ʻole ka momona),
• ʻO ka maʻi diabetes mellitus type 2 (non-insulin-dependant),
• ʻO ka hoʻomohala ʻana o nā ʻōpū cell pancreatic beta (me ka insulinomas),
• ʻO nā tumors endocrine e hiki ke hana i ka insulin,
• Hōʻeha i ka islet beta cell cell,
• Hoʻopau i ʻole ka hopena hoʻokō,
• ʻO ka maʻi Hyperthyroidism (hypersecretion o nā hormone thyroid),
• ʻO Cirrhosis o nā ate (kahi hoʻololi i ke ʻano o kāna mau ʻonekele),
• ʻO ka hypoglycemic hyperinsulinemia (kahi kūlana o ka hoʻemi ʻana i ka glucose glucose) ma ke ʻano koʻikoʻi
• ʻO ka lawe ʻana i nā lāʻau lapaʻau hypoglycemic (a me ke ʻano o kaonyony)
• E hoʻohuli i ka hemahema PC1 3.

Kākau: ma mua o 80% o nā mea maʻi me ka insulinoma, ʻoi aku ka kiʻekiʻe o ka proinsulin ma mua o ka maʻamau. ʻO ia ke kumu o ka nānā a me ka kikoʻī o ka hōʻike no ka ʻike ʻana i kēia ʻano paleke he 75-95%.

Me ka lawa ʻole o ka loli o ka convertase, e hoʻonui ʻia ka proinsulin ma hope o ka ʻaina, a me ka insulin, ʻo ia hoʻi, e hoʻohaʻahaʻa ʻia. E hoʻoulu hou nā ʻano hanana pono ole hormonal, no ka laʻana, ka hiʻona haʻahaʻa o cortisol, ke ʻano kūpono o ka paona kino, nā maʻi ʻōnaehana o ka hanana.

Hoʻomākaukau ʻai

Kaomi noiʻi biomaterial: koko venous.

Ke kaʻina hana: venipuncture o ka ulnar vein e like me ke algorithm maʻamau.

Ka manawa hoʻohālike: 8: 00-10: 00h.

Ke ʻano hoʻohālike: ma ka ʻōpū ʻole (ʻo ka manawa hoʻokū ʻai pō i ka liʻiliʻi o 10 mau hola, inu ʻia ka wai me ka ʻole o ka wai a me ka paʻakai).

• ma ka kuapo o ka hōʻike ka mea e pāpā ʻia i ka ʻai ʻana i ka momona, ke kīwī, nā meaʻai kīpī, inu i nā mea inu wai a me nā mea ʻona (ʻawaʻa, kofe a me nā kakū, ka ikaika, me nā mea like,).
• 1-2 mau lā ma mua o ka hoʻāʻo, e hoʻokaʻawale ʻia nā kūlana kaumaha, pono e haʻalele ʻia nā hana haʻuki, e kaupalena ʻia ke kaulike ʻana.
• pāpā ʻia aku ka uahi i ka hola ma mua o ka nānāʻana (i ka palaka, vape, hookah),
• 20-30 mau minuke ma mua o ka hoʻopunipuni ʻana, pono e lawe i kahi noho a noho paha, e hoʻomaha, e pale iā ʻoe iho i kekahi kaumaha o ke kino a i ka noʻonoʻo.

Nui! Inā ke hoʻomau ʻoe i ka mālama ʻana i nā hormones a i ʻole nā ​​lāʻau lapaʻau ʻē aʻe, e kūpale e haʻi i ko lākou inoa, ka lōʻihi o ka hoʻokele ʻana a me ka ʻōlelo ʻana i kāu kauka ma mua o ka hoʻokau ʻana i ka hōʻike proinsulin.

Ua kuhikuhi paha ʻoe iā ʻoe:

Palapala palapala

1. ʻO ka Encyclopedia o nā Kauka Lapaʻau Kaulepau, Ed. N.U. Hōʻike. Ka hale hoʻopuka
   "Labinform" - M. - 1997 - 942 p.
2. Z. Ahrat Ali, K. Radebold. - Insulinoma. - http://www.emedicine.com/med/topic2677.htm
3. Nā mea hana o ka ʻoihana - mea hana o nā hoʻonohonoho.
4. Buke a Tietz o nā kemakanui a me nā diagnostics molekole (ed. Burtis C., Ashwood E., Bruns D.) - Saunders - 2006 - 2412 p.
   

• ʻO ka hoʻomohala ʻana o nā kūlana hypoglycemic. Hoʻopau ʻana i ka insulin.
• ʻO ka loiloi beta function cell pancreatic (e nānā pū nō hoʻi: insulin (hōʻike ʻeha 172) a me C-peptide (hōʻike ʻae Nole 148).

ʻO ka wehewehe ʻana i nā hopena noiʻi he ʻike no ke kauka e hele nei a ʻaʻole ia he maʻi. ʻAʻole hiki ke hoʻohana ʻia ka ʻikepili i kēia pauku no ka hoʻopaʻa ʻana iho a me ka lāʻau ponoʻī iā ʻoe iho. Hana ke kauka i kahi maʻi kūpono me ka hoʻohana ʻana i nā hopena ʻelua o kēia hoʻokolokolo a me nā ʻike pono mai nā kumuwaiwai ʻē aʻe: ka mōʻaukala, nā hopena o nā hoʻokolohua ʻē aʻe, etc.

Nā pūʻulu helu o ka ana i loko o ke kikowaena kūʻokoʻa o INVITRO: pmol / l.

Proinsulin

Hoʻomau

ʻO Proinsulin, he hormone, ke kumu mua o ka insulin, ua hana ʻia ma ka pancreatic β-cells. Ma lalo o ka hana a proteases, kahi i hoʻopili ʻia ai ka C-peptide mai ka molekole proinsulin a me ka insulin hoʻoikaika. ʻO ka maʻamau, kokoke i nā proinsulin a hoʻohuli i ka insulin hoʻoikaika. He wahi liʻiliʻi wale nō o ka proinsulin i loaʻa i ke koko. Hōʻike ka pae o ka proinsulin i ke koko i ka mokuʻāina o nā β-cell nā pancreatic. Ke koho nei i ka pae o ka proinsulin e hoʻohana ʻia ma ka maʻi maʻi maʻi pancreatic β-cell tumors (insulin). ʻO ka hapa nui o nā poʻe maʻi me ka insulinomas e loaʻa ka piʻi o ka neʻe o ka insulin, C-peptide a me nā proinsulin, akā i nā hihia loaʻa ʻole, hiki ke hoʻonui ʻia ke pae o ka proinsulin. He ʻoi aku ka hana haʻahaʻa o Proinsulin (ma kahi o 1:10) a me kahi hapalua hapa ola (e like me 3: 1) ma mua o ka insulin. ʻOiai ka hana haʻahaʻa haʻahaʻa o proinsulin, kahi hōʻokoʻa o ka hoʻokaʻawale ʻana i kona kiʻekiʻe e hiki ai i ke kumu hypoglycemic wale nō. I ka hoʻololi hewa ʻana i nā cells-cell, ua hoʻololi ke kahe o nā huahana huna i ka proinsulin. ʻO ka ratio proinsulin / insulin molar no ka insulinomasia ma mua o 25%, i kekahi manawa a hiki i 90%. Hiki ke ʻike ʻia ka hoʻonui ʻana o ka proinsulin i nā mea maʻi me ka hiki ʻole o ka renal, cirrhosis, hyperthyroidism.

Me ka hoʻonui ʻia ʻana o ka proinsulin e ka pancreas, no ka laʻana, me ka pale ʻana o ka ʻiole i ka insulin a i ʻole ma lalo o ke ʻano o nā lāʻau huna ʻana e hoʻonaʻauao (me ka hoʻohālike ʻana, sulfonylureas), ka loli ʻana o ka proinsulin i ka insulin ikaika e pau, no ka nui o ka hoʻōla catalytic o nā proteases. Ke alakaʻi nei kēia i kahi hoʻonui i ka neʻe o ka proinsulin i ke koko a me kahi hoʻokaʻina o ka neʻe o ka insulin ikaika. No kēia kumu, hiki ke manaʻo ʻia ka hoʻonui ʻia o ka hoʻoulu ʻana o proinsulin i ke koko ke lilo ʻana i hōʻailona o kahi hōʻino o ka hana o nā pancreatic β-cells.

ʻO ka Proinsulin a me ke ʻano 2 Diabetes

Hōʻike ʻia ka maʻi diabetes mellitus type 2 e ka pale kino a me ka hoʻoneʻe ʻia o ka pancreatic. ʻO ka paleʻana i ka insulin he laʻana i ka hopena metabolic impaired i ka exogenous a i ka endogenous insulin. ʻO kēia kahi maʻi maʻamau, ʻike ʻia ma mua o 50% o nā mea maʻi me ka hypertension. ʻOi aku ka maʻamau ma nā poʻe kahiko, akā hiki nō ke hoʻomaka i ka wā kamaliʻi. Kūpaʻa mau ka hoʻoliʻi ʻana me ka insulin a hiki i ka hoʻomohala ʻana o ka maʻi metabolic. ʻO ka poʻe me ka hypertension, obesity, dyslipidemia, a i ʻole ke ahonui i ka hoʻohaʻahaʻa ʻana i ka glucose i hoʻonui ʻia ka nui o ka ulu ʻana i ka kūʻē o ka insulin. ʻAʻole maopopo i ka mīkini hana piha no ka hoʻomohala ʻana i ka insulin. Hiki i nā pilikia ke alakaʻi i ka pale ʻana i ka insulin ma nā pae aʻe: prereceptor (abnormal insulin), ʻĀpana (hoʻemi i ka helu a i ʻole ka pilina o nā mea nānā), ka lawe ʻana i ka glucose (hoʻemi i ka helu o nā mololi GLUT4), a me ka postreceptor (hōʻailona transduction a me ka phosphorylation). Ke manaʻoʻiʻo nei kēia ʻo ke kumu nui o ka pale ʻana i ka insulin o nā maʻi postreceptor o ka hoʻoili ʻana i ka hōʻailona o ka insulin.

ʻO Proinsulin ma ke ʻano he hopena pilikia no ka maʻi cardiovascular

ʻO ke kū'ē o ka Tissue i ka insulin e pili kokoke i ka hanana o myocardial infarction, stroke, a me nā maʻi ʻē aʻe o macrovascular. No laila, ʻo ka nānāʻana i ke kūlohelohe o ka pale i ka insulin he mea nui loa. Aia a hiki i kēia manawa, ʻo ka hoʻokalakupua ʻana o ka pale ʻana i ka insulin e hiki wale nō me nā hana nui. Ua hōʻoia ʻia nā haʻawina hou o ka haukapila i ke ʻano nui o ka proinsulin ma ke ʻano he hōʻailona ʻana o ka hōʻailona kūʻē o ka insulin 6, 7.

Hoʻonui iki nā pae o ka proinsulin a me ka des-31,32-proinsulin (kahi huahana kaʻoki o ka proinsulin) i pili pū kekahi me ka hoʻonui nui o ka hoʻomohala ʻana i ka arteriosclerosis a me ka maʻi naʻau coronary. I kēia lā, ʻaʻohe mea kaha e wehewehe ana i ke ʻano o ka pale ʻana o ka insulin i nā hōʻeha o ka atherosclerotic o ka ʻōnaehana cardiovascular. Hiki i ka insulin ke hopena pololei ma ka atherogenesis, ma muli o kona hiki ke hoʻoulu i ka syntid synthesis ma ka paia arterial a me ka hoʻomaʻamaʻa ʻana o nā ʻalika kūlohelohe o ka pā o ka pa. ʻO ka atherosclerosis, ma ka ʻaoʻao ʻē aʻe, he mea paha i hiki ke hoʻopiʻi i ka maʻi kūlohelohe metabola, e like me ka hypertension, ʻoluʻolu hoʻonaninani o ka glucose, a me ka dyslipidemia.

ʻO Proinsulin ma kahi hōʻailona diagnostic

ʻO ka hoʻoholo ʻana o nā pae proinsulin serum i kikoʻī no ka nānā ʻana i ka hana o ka mea huna i ka ʻimi o ka pancreatic β-cell. Hoʻokumu i kēia noiʻi ʻana, hiki ke hoʻoholo ʻia nā mea hoʻohālike me ka loiloi ʻana i ka lapaʻau ʻana.

ʻO nā hualoaʻa o kahi noiʻi o proinsulin i nā maʻi me nā maʻi maʻi type 2

Proinsulin 11.0 pmol / L

(ka hewa o nā mea huna o cells-cell o ka pancreas)

Loaʻa paha ke pili ʻana ka pale kino ʻana i ka insulin i ka ʻekekema i loaʻa ʻole ʻia. Paipai ʻia ke ʻano no ka pale ʻana i ka insulin. Me ka hoʻolālā kūleʻa (ma hope o 3 mau mahina), ka nui o ka proinsulin i ke koko.

Nā hopena o kahi noi ʻana o ka proinsulin i nā maʻi me ka maʻi mellitus

Proinsulin> 11.0 pmol / L

Hoʻomaopopo ʻia ka noiʻi ʻana e hoʻomālamalama i ka maʻi diabetes no ka maʻi diabetes a i ʻole ka insulinoma a me ka ʻike ʻana i nā mea pōpilikia no ka hoʻomohala ʻana i ka maʻi cardiovascular.

Nā hōʻailona no ke kumu o ke aʻo ʻana:

• ʻO ka hoʻomohala ʻana o nā kūlana hypoglycemic
• Hoʻohālikelike Insulin
• ʻO ka loiloi function-cell function Pancreatic
• ʻO ka hoʻomohala ʻana o ka pale o ka insulin

Hoʻonui i ka hōʻailona:

• ʻAno maʻi II
• ʻO ka hyperproinsulinemia aila
• Kaneka β-cell pancreatic (insulinomas)
• Hoʻokomo ʻia nā kinakalina Insulin
• Nā hemahema huna pancreatic β-cell
• Ke kūlohelohe ʻia
• Hoʻopau ʻole nā ​​hopena hanaliki
• Hāpopo
• Cirrhosis
• ʻO ka maʻi hypoglycemic koʻikoʻi
• Kūkūlima o ka sulfonylureas (nā lāʻau hypoglycemic)

Mākaukau hoʻomākaukau ʻana

Hāʻawi ʻia ke koko no ka noiʻi ʻana ma kahi ʻōpū ʻole i ke kakahiaka, ʻoiai ʻaʻole i ʻāpala a i ʻole kaʻaina kofe. Hoʻomaopopo ʻia ka inu ʻona wai.

ʻO ka manawa manawa mai ka manawa hope a hiki i ka hoʻokolokolo he ʻewalu mau hola.

I ka lā ma mua o ke aʻo ʻana, mai lawe i nā mea inu ʻona, ka momona momona, e kaupalena i ka hana kino.

ʻO ka wehewehe ʻana i nā hopena

ʻAno maʻamau: 0,5 - 3.2 pmol / L.

Hoʻonui:

2. Ka hemahema o ka hoʻololi ʻana iā PC1 / 3.

3. hyperproinsulinemia ʻohana.

4. Huli renal wā maʻi.

5. Pākaʻi ʻaina 2.

6. Hyperthyroidism - hyperthyroidism.

7. Ka lawe ʻana i nā lāʻau lapaʻau hypoglycemic - derivatives o sulfanylurea.

Hoʻemi:

1. Kahi 1 maʻa mellitus (hilinaʻi-kū i ka insulin).

E koho i nā hōʻailona e hoʻolalelale aku ai iā ʻoe, e pane i nā nīnau. E ʻike i ka pilikia o kāu pilikia a i ʻole e ʻike i ke kauka.

Ma mua o ka hoʻohana ʻana i ka ʻike i hāʻawi ʻia e ka pūnaewele medportal.org, e heluhelu i nā huaʻōlelo o ka ʻae a ka mea hoʻohana.

ʻO ka ʻikepili hoʻohana

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ʻO ka wehewehe

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ʻAʻole loa ka lawelawe ʻana o ka pūnaewele ʻo medportal.org a i ʻole kekahi ʻaoʻao ʻē aʻe i pili i ke kaʻina o ka hāʻawi ʻana i ka ʻike e pili ana i ka hōʻeha a me ka hōʻino paha hiki iā ʻoe ke loaʻa mai ka ʻoiaʻiʻo e hilinaʻi ʻoe i ka ʻike i ʻike ʻia ma kēia pūnaewele.

ʻO ka lawelawe ʻana o ka pūnaewele medportal.org hana a hana i nā hana āpau i ka wā e hiki mai ana e hōʻemi i nā hemahema a me nā hewa o nā ʻike i hāʻawi ʻia.

ʻAʻole ka hōʻoia ʻana o ka luna o ka pūnaewele medportal.org i ka hiki ʻole o nā hemahema ʻenehana, e pili pū me ka hana o ka polokalamu. ʻO ka lawelawe ʻana o ka pūnaewele medportal.org e hana i nā hana āpau i ka hiki ke hoʻopau i nā hemahema a me nā hemahema inā loaʻa lākou.

Ua ʻōlelo ʻia ka mea hoʻohana, ʻaʻole i kuleana ka Manaʻo o ka pūnaewele medportal.org no ka kipa ʻana a me ka hoʻohana ʻana i nā kumuwaiwai o waho, nā loulou e pili ai ma ka pūnaewele, ʻaʻole hāʻawi i ka ʻae i kā lākou ʻike a ʻaʻole ka kuleana no ko lākou loaʻa.

Loaʻa i ka alakaʻi o ka pūnaewele medportal.org ka kuleana e hoʻopanee ai i ka hana o ke kahua, mahele a ʻoli paha a hoʻololi i kona ʻike, hana i nā loli i ka Hoʻohui Mea Hoʻohui. ʻO kēlā mau loli i hana ʻia ma ka manaʻo wale nō o ka Hoʻolālā me ka ʻole o ka hoʻolaha ʻana i ka mea hoʻohana.

Hōʻike ʻoe ua heluhelu ʻoe i nā huaʻōlelo o kēia Manaʻo Mea hoʻohana, a ʻae i nā huaʻōlelo a pau o kēia ʻāpono.

ʻO ka ʻike hoʻolaha hoʻolaha e pili ana i ka waiho ʻia ma luna o ka pūnaewele aia kahi ʻae kūlike me ka mea hoʻolaha e hōʻailona ʻia "he hoʻolaha."

Proinsulin Assay - Ka hoʻāʻo ʻana i ka hana β-Cell

ʻO nā hoʻokolohua Laboratory no ka maʻi maʻi, me ka hoʻomehana ʻana, he pāʻani nui. ʻAʻole mau ka hōʻailona o ka maʻi a me ka pae o ka glycemia o ke koko e hōʻike ana i ke kaʻina pathological maoli i loko o ke kino, kahi e alakaʻi ai i nā hala o ke diagnostic i ka hoʻokumu ʻana i ke ʻano o ka maʻi maʻi.
ʻO Proinsulin ka hana like ʻole o ka protein protein o ka insulin i synthesized e insulin-cells of islets i ka pancreas i nā kānaka. Ma hope o ka hoʻohemo ʻana mai ka proinsulin, ka kahua o ka protein (kahi i ʻike ʻia ʻo C-peptide), loaʻa i kahi moleki insulin, nāna e hoʻoponopono i ka metabolism holoʻokoʻa o ke kino o ke kanaka, ʻoi aku ka catabolism o nā glucose a me nā puna hou.

Mālama ʻia kēia mea i loko o nā pūhaka o nā mokupuni o Langerhans, kahi e hoʻohuli ai i ka insulin hormone ikaika. Eia naʻe, pili ka 15% o ka waiwai i komo i ke kahawai ke loli ʻole. Ma ke ana ʻana i kēia helu, ma ka hihia o C-peptide, hiki i kekahi ke hoʻoholo i ka hana o nā cells-cell a me ko lākou hiki i kā lākou hana i ka insulin. ʻO ka Proinsulin ka liʻiliʻi o ka hana catabolic a he lōʻihi aku i ke kino o ke kanaka ma mua o ka insulin. Eia naʻe, ʻoiai, ʻo ka nui o nā kiʻekiʻe o ka proinsulin (i ʻike ʻia i ka wā o nā kaʻina oncological i nā pancreas (insulinoma, etc.)) hiki ke hoʻonāukiuki i ka hypoglycemia i loko o nā kānaka.

Ka hoʻomākaukau ana no kahi hōʻike proinsulin

No ka hoʻoholoʻana i ke kiʻekiʻe o ka proinsulin i kanaka, hōʻiliʻili ʻia ke koko venous. Ma mua, pono ka mea maʻi e hoʻopiʻi i kahi o nā ʻōlelo paʻakikī ʻaʻole paʻakikī, kahi e like me ka hoʻomākaukau no ka noi ʻana biochemical e hoʻoholo i ka pae glucose.

1. Lawe ʻia ka hāʻawi koko koko i ke kakahiaka ma mua o ka ʻaina awakea, ma luna o ka ʻōpū ʻole. Hoʻoholo ʻia ia e lawe i kahi liʻiliʻi o ka wai i heluhelu ʻia, me ka ʻole o nā mea hoʻohui hoʻohui.
2. ʻO ka lā ma mua o ka hoʻopaʻa ʻia, pono ia e hoʻokaʻawale i ka ʻai ʻana i nā mea inu wai ʻawa, ka ulaula, ka hoʻoikaika kino ʻana, a me ka mālama ʻana i nā lāʻau lapaʻau, inā hiki, ʻoi aku ka nui o nā lāʻau lapaʻau haʻahaʻa (glibenclamide, maʻi maʻi, amaryl, etc.).

Nā hōʻike no ka noiʻi ʻana i nā kahu hana

Hana ʻia ka loiloi no ka proinsulin e like me ke kuhikuhi ʻana i nā lāʻau lapaʻau, i mea e wehewehe pono ai i kēia mau ʻike.

• ʻO ka wehewehe ʻana i ke kumu o nā kūlana hypoglycemic wikiwiki.
• Ka ʻike ʻana i nā insulin.
• ʻO ka hoʻoholoʻana o ke ʻano o ka hana hana o ka β-cells cells.
• ʻO ka hoʻoholo ʻana o ke ʻano maʻi o ka maʻi mellitus o ka maʻi mellitus (type 1 a i ʻole 2).

Proinsulin Assay - Ka hoʻāʻo ʻana i ka hana β-Cell

ʻO ka hana koʻikoʻi e hana i ka hoʻokolohua pololei e pāʻani ʻia e nā hoʻokolohua hoʻāʻo. Hoʻomaka ʻole ʻia nā hōʻailona o ka maʻi a me ke kō o ke koko i ke ʻano o nā maʻi maoli i loko o ke kino, hiki iā ʻoe ke hana hewa i ka maʻi ʻana i ke ʻano o ka maʻi maʻi.

ʻO ka Proinsulin he prohormone (kahi hana ʻole o ka pauku o ka protein protein o ka insulin), ka mea i hana ʻia e nā kino beta o ka pancreas kanaka. Hoʻokuʻu ʻia ka C - peptide (ka pūmala protein) mai ka proinsulin, ua hoʻokumu ʻia kahi moleki insulin, nāna e hoʻoponopono i ka metabolism o ke kino o ke kanaka, i hoʻopili pinepine ʻia i ka luku ʻia o ka glucose a me nā kō.

Hoʻololi ʻia kēia mea hoʻohuli i ka insulin hāneʻe ikaika i loko o nā pā o nā kahakai o Langerhans. Akā 15% komo i ke kahe koko i kāna ʻano kumu. Inā ʻoe e ana i ka nui o kēia waiwai, hiki iā ʻoe ke hoʻoholo i ka nui o ka β - nā mea maʻi hiki ke hana i ka insulin. Ma ka proinsulin, hana like ka catabolic, a ua hiki ke noho i ke kino ma mua o ka insulin. Akā ʻo nā dosis nui o kēia mea i ka pancreas (me nā hana oncological i kēia ʻōpū) hiki ke hoʻonāukiuki i ka hypoglycemia i loko o nā kānaka.

ʻO ka hoʻomākaukau ma mua o ka loiloi no ka pronesulin
ʻO ka ʻikepili ma ka nui o ka proinsulin i loko o ke kino e ʻohi ʻia mai ke koko venous. Ma mua o ka hōʻike ʻana, e hahai ana ka mea maʻi i kekahi o nā ʻōmole e like me ka hoʻomākaukau ʻana ma mua o ka loiloi biochemical e hoʻoholo i ka pae o ka glucose i loko o ke koko.
- Hoʻopili ʻia ke kōpili koko i ke kakahiaka ma ka ʻōpū ʻole. Hiki iāʻoe ke hoʻohana i ka wai maʻemaʻe me kaʻole o nā mea hoʻohui.
- No 24 mau hola, inu ʻawaʻawa, inuahi ʻaina, hoʻokaʻawale a me nā hana pilikino, ka lawe ʻana i nā lāʻau lapaʻau, ʻoi aku ka lāʻau lapaʻau haʻahaʻa e like me ka glibenclamide, diabetes, amaryl, etc.

Nā hōʻailona no ka hoʻoili
Ke kuhikuhi ʻia nei ka hoʻāʻo ʻana e ke kauka e hoʻoholo ai i kēia ʻano kumu:
- Hōʻōkuhi wikiwiki
- Ka ho'ākāka o nā insulinomas
- Ke hoʻoholo nei i ka hana o cells-cell o ka pancreas
- Ka ʻike o ke ʻano maʻi o ka maʻi maʻi

Ka ʻikepili ʻana o ka ʻikepili ʻike
Hoʻonohonoho ʻia nā Proinsulin ma kahi kanaka olakino ma mua o 7 pmol / l, hoʻowalewale ʻia o ka 0.5 - 4 pmol / l ka mea, hiki ke loaʻa nā mea hana.

Me nā maʻi maʻamau 1, loaʻa kahi hāʻule nui i ka kaʻe o ka proinsulin i ke koko. ʻO ka hoʻonui nui aʻe o ka paepae maʻamau e hōʻike ana i ka maʻi maʻamau 2 type, oncology pancreatic, thyroid, ʻōpū a me nā alakaʻi.