Hoʻopaʻa ʻo Amoxiclav i nā keiki a me nā pākeke
ʻO ka pauka no ka hoʻomākaukau ʻana no ke kāpena ʻana i ka waha o ka waha mai ka keʻokeʻo a i ka keʻokeʻo-keʻokeʻo, ʻo ka hoʻōla i hoʻomākaukau ʻia he homogeneous, mai ke keʻokeʻo a ʻeleʻele.
| 5 ml o ka pohō hoʻohemo ʻana. | |
| amoxicillin (i ke ʻano o kahi trihydrate) | 125 mg |
| kaʻiole clavulanic (ma ke ʻano o ka paʻakai paʻakai) | 31.25 mg |
Nā mea kūʻai: kaomi citric anhydrous, anhydrous sodium citrate, sodium benzoate, microcrystalline cellulose, sodium carmellose, xanthan gum, colloidal silicon dioxide, silicon dioxide, sodium saccharinate, mannitol, flavings (strawberry, wild cherry, lemon).
25 g - nā hue a me nā aniani o ke aniani me kahi kikoʻī o 100 ml (1) i piha i kahi pākuʻi wai / pipette - nā pā kīpē o ke kāleka.
ʻO ka pauka no ka hoʻomākaukau ʻana no ke kāpena ʻana i ka waha o ka waha mai ka keʻokeʻo a i ka keʻokeʻo-keʻokeʻo, ʻo ka hoʻōla i hoʻomākaukau ʻia he homogeneous, mai ke keʻokeʻo a ʻeleʻele.
| 5 ml o ka pohō hoʻohemo ʻana. | |
| amoxicillin (i ke ʻano o kahi trihydrate) | 250 mg |
| kaʻiole clavulanic (ma ke ʻano o ka paʻakai paʻakai) | 62.5 mg |
Nā mea kūʻai: kaomi citric anhydrous, anhydrous sodium citrate, sodium benzoate, microcrystalline cellulose, sodium carmellose, xanthan gum, colloidal silicon dioxide, silicon dioxide, sodium saccharinate, mannitol, flavings (strawberry, wild cherry, lemon).
25 g - nā hue a me nā aniani o ke aniani me kahi kikoʻī o 100 ml (1) i piha i kahi pākuʻi wai / pipette - nā pā kīpē o ke kāleka.
ʻO ka pauka no ka hoʻomākaukau ʻana no ke kāpena ʻana i ka waha o ka waha mai ka keʻokeʻo a i ka keʻokeʻo-keʻokeʻo, ʻo ka hoʻōla i hoʻomākaukau ʻia he homogeneous, mai ke keʻokeʻo a ʻeleʻele.
| 5 ml o ka pohō hoʻohemo ʻana. | |
| amoxicillin (i ke ʻano o kahi trihydrate) | 400 mg |
| kaʻiole clavulanic (ma ke ʻano o ka paʻakai paʻakai) | 57 mg |
Nā mea kūʻai: kaomi citric anhydrous, anhiddrous sodium citrate, microcrystalline cellulose, carmellose sodium, xanthan gum, colloidal silicon dioxide, silicon dioxide, sodium saccharin, mannitol, nā ʻono (strawberry, wild cherry, lemon).
8.75 g - 35 ml mau aniani kīʻaha (1) hoʻopau me kahi pipette kūmole - nā pā pepa.
12,5 g - nā hue a me nā aniani o ke aniani me kahi kikoo o 50 ml (1) i piha me ka pipette dosing - nā pā o ka pahu paʻi.
17.5 g - nā ipu aniani me nā pololi he 70 ml (1) hoʻopiha me kahi pipette dosing - nā kāpena pepa.
35 g - 140 ml mau aniani nā aniani (1) hoʻopiha me ka pipette dosing - nā pepa pepa.
Ka hana lāʻau lapaʻau
ʻO Amoxiclav ® kahi hui o amoxicillin - penicillin semisynthetic me kahi ākea o ka hana antibacterial a me ka clavulanic acid - kahi pale lipi e hoʻihoʻi ʻole o β-lactamases. Hoʻokomo ka hoʻohuihui Clavulanic i kahi paʻakikī paʻa ʻole i kēia mau enzyme a me ka hōʻoia i ka kūʻē o ka amoxicillin i nā hopena o nā β-lactamases i hoʻolālā ʻia e microorganisms.
ʻO ka mole Clavulanic, like me ka hana i ka antibiotics beta-lactam, he hana intrinsic antibacterial nāwaliwali.
Loaʻa i ka Amoxiclav ® kahi ākea ākea o ka hana antibacterial.
ʻO ia ke kūleʻa e kū'ē i nā pilikia o ke kaʻaxicillin, e komo pū ai i nā hana o ke kūmole β-lactamases, incl ʻO nā huahelu aerobik Gram-positibo: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus bovis, Staphylococcus aureus (koe wale nō me nā māka, ke ʻano o ka Sticylococcus epidermidis. : Bordetella pertussis, Brucella spp., Campylobacter jejuni, Escherichia coli, Gardnerella vaginalis, Haemophilus influenzae, Haemophilus ducreyi, Klebsiella spp., Moraxella catarrhalis spp., Neisseria gonorrhoeae spppp, Neisseria gonorrhoellea , Vibrio cholerae, Yersinia enterocolitica, Helicobacter pylori, Eikenella corrodens, anaerobic gram-positive bacteria: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Actinomyces israelii, Fusobacterium spp., Prevotella spp., Gram-negative anaerobes: Bacteroides spp.
Lapaʻau lāʻau
ʻO nā hiʻohiʻona nui o ka pharmacokinetic o ka amoxicillin a me ka acid clavulanic i like.
ʻEleʻa maikaʻi nā māhele ʻelua ma hope o ka lawe ʻana i ka lāʻau lapaʻau i loko, ʻaʻole e hoʻopilikia i ka pae o ke kao ʻana. Loaʻa ka C max i loko o ke kaila koko he 1 h ma hope o ka hoʻokele ʻana. ʻO nā waiwai o C max no ka amoxicillin (ma muli o ke ʻano) he 3-12 μg / ml, no ka wai clavulanic - e pili ana iā 2 μg / ml.
Hōʻike ʻia nā ʻaoʻao ʻelua i ka nui o ka hoʻoili ʻana i nā ʻōmole o nā kino a me nā ʻōpio (pūpū, ke pepeiao waena, nā pleural a me nā peritoneal wai, ka ʻōpū, ka ovaries, a me nā mea hou aku). Hoʻopaka hoʻi ʻo Amoxicillin i ka wai synovial, ate, prostate gland, palatine tonsils, kiko o ka ʻōpū, ka puʻuwai ʻana, nā mea huna o nā sinuses, ka lawaiʻa, nā mea huna huna bronchial.
ʻO Amoxicillin a me clavulanic acid ʻaʻole i komo i ka BBB me ka meninges uninflamed.
ʻO Amoxicillin a me clavulanic acid e hoʻowalewale i ka pale o ka placental a ma o ka nui o nā wahi i hoʻopili ʻia i loko o ka waiū umauma. Hōʻikeʻo Amoxicillin a me clavulanic acid i ka hoʻohaʻahaʻa haʻahaʻa i nā protein plasma.
Amoxicillin i hoʻoneʻe ʻia i ka ʻaoʻao, clavulanic acid ua hoʻopiʻi ʻia i ka metabolism ikaika.
Hoʻopili ʻia ʻo Amoxicillin e nā keiki i aneane e loli a ka huna ʻia o ka tubular a me ka filtration glomerular. Hoʻokumu ʻia ka hoʻohuihui Clavulanic e ka filtration glomerular, ma kahi ʻāpana i nā metabolites. Hiki ke hoʻopaneʻe ʻia ka liʻiliʻi ma o nā ʻōpū a me nā ʻōpū. T 1/2 o ka amoxicillin a me ka waikawa clavulanic he 1-1,5 hola.
ʻO ka pharmacokinetics i nā hihia lapaʻau kūikawā
Ma nā hana kūleʻa nui, hoʻonui ʻia ʻo T 1/2 e 7.5 hola no ka amoxicillin a hiki i nā hola 4 no 4 o ka clavulanic acid. Hoʻokuʻu ʻia nā ʻaoʻao ʻelua i ka hemodialysis a me nā helu liʻiliʻi e nā dialysis peritoneal.
Nā ʻōmole Amoxiclav ®
Nā maʻi ʻeha e hōʻake ʻia e nā ʻōpala hikiʻole i nā microorganisms:
- nā hopena o ka ʻōpū hanu o luna a me nā mea komo ENT (e pili ana i ka sinusitis a me ke keaka sinusitis, nā pāpā a me ka ukiuki otitis, pharyngeal abscess, tonsillitis, pharyngitis),
- nā maʻi o ka ʻōpū hanu haʻahaʻa loa (me ka hoʻohui ʻia o ka bronchitis nui me ka superinfection bakalula, bronchitis maʻi, pneumonia),
- maʻi maʻi maʻi urinary
- maʻi maʻi gynecological
- ka hopena o ka ʻili a me nā kiko palupalu, e komo pū me nā holoholona a me ke kanaka.
- nā iwi a me nā hui pili kino,
- biliary tract infection (cholecystitis, cholangitis),
- nā maʻi odontogenic.
| ʻIke ICD-10 | Hōʻike ʻano |
| H66 | Pūnaewele ma Purulent a i ʻole i kikoʻī ʻia |
| J00 | Nasopharyngitis kūlohelohe (ihu runny) |
| J01 | Sinusitis huehue |
| J02 | ʻO ka pharyngitis akue |
| J03 | Tonsillitis huehue |
| J04 | ʻO ka laryngitis hoʻonani a me ka tracheitis |
| J15 | ʻO nā maʻi maʻi pneumonia, ʻaʻole kahi ʻokoʻa i kahi ʻē |
| J20 | Nā keleahi bronchitis |
| J31 | Rhinitis wāhole, nasopharyngitis a me pharyngitis |
| J32 | Sinusitis wāhole |
| J35.0 | He mau tonsilitis wāwahi |
| J37 | ʻO ka laryngitis maʻi a me ka laryngotracheitis |
| J42 | Kaleka kaahi palapa, ʻaʻole i hōʻike ʻia |
| K05 | ʻO Gingivitis a me nā maʻi periodontal |
| K12 | ʻO Stomatitis a me nā hui pili |
| K81.0 | Cholecystitis akena |
| K81.1 | ʻEclelo a me ke kakā |
| K83.0 | Cholangitis |
| L01 | Impetigo |
| L02 | ʻO ka pohō ʻili, hoʻolapalapa a me ka carbuncle |
| L03 | Phlegmon |
| L08.0 | Pyoderma |
| M00 | ʻĀpilikia Pyogenic |
| M86 | Osteomyelitis |
| N10 | ʻO ka nephritis acute-interstitial akue (pyelonephritis acute) |
| N11 | Nephritisitis tubulointerstitial maʻi (pyelonephritis palola) |
| N30 | Cystitis |
| N34 | ʻO ka maʻi urethritis a me ka urethral syndrome |
| N41 | Hoʻopilikia i nā maʻi o ka prostate |
| N70 | Salpingitis a me ooporitis |
| N71 | ʻO ka maʻi o ka ʻōpū ma mua o nā maʻi, koe wale nō no ka cervix (me ka endometritis, myometritis, metritis, pyometra, kaʻe ʻana o ka ʻōpū) |
| N72 | ʻEha nā maʻi lōkahi (komo i ka cervicitis, endocervicitis, exocervicitis) |
| T14.0 | ʻO ka hōʻeha ʻeha loa o kahi wahi i ʻike ʻole ʻia o ke kino (me ka abrasion, bruising, bruise, hematoma, ʻalā o kahi manuʻomaka mea ʻole hona) |
Ka hoʻoponopono ʻia ʻana
ʻO nā lono i kēlā me kēia lā he 125 mg + 31.25 mg / 5 ml a me 250 mg + 62.5 mg / 5 ml (e hōʻoluʻolu i ka hana kūpono o nā hoʻopiʻi, ʻo kēlā me kēia pa pākīpī he 125 mg + 31.25 mg / 5 ml a 250 mg + 62.5 mg / 5 ml me ka nui o ka 5 ml a i ʻole puka i ka pipette i puka.
ʻO nā pēpē a me nā keiki a hiki i 3 mau makahiki kau i kuhikuhi ʻia 30 mg / kg (no ka amoxicillin) / lā, i hoʻokaʻawale ʻia i 2 mau maʻi (ʻo kēlā me kēia mau hola 12), no nā keiki i ʻoi aku o 3 mau mahina - mai 20 mg (no ka amoxicillin) / kg / lā no ka hoʻopōmaikaʻi ʻana me ke aniani uha o ka papa a hiki i 40 mg / kg (e like me amoxicillin) / lā no nā maʻi ʻino loa a me ka maʻi ʻōpū o ka ʻōpū, hoʻokaʻawale i nā maʻi he 3 (i kēlā me 8 mau hola).
ʻO ke ʻano o nā pona i hāpai ʻia ma ke ʻano o ke kino o ke keiki a me ka nui o ka maʻi.
| Kauka kino (kg) | Nā ʻōpio (kahi kokoke) | Nā maʻi haehae / paleha ʻia | ʻO nā maʻi koʻikoʻi | ||
| 125 mg + 31.25 mg / 5 ml | 250 mg + 62.5 mg / 5 ml | 125 mg + 31.25 mg / 5 ml | 250 mg + 62.5 mg / 5 ml | ||
| 5-10 | 3-12 mahina | 3 × 2.5 ml (1/2 lita.) | 3 × 1.25 ml (1/4 l.) | 3 × 3.75 ml (3/4 l.) | 3 × 2 ml (1/4 - 1/2 lita.) |
| 10-12 | 1-2 mau makahiki | 3 × 3.75 ml (3/4 l.) | 3 × 2 ml (1/4 - 1/2 lita.) | 3 × 6.25 ml (1 1/4 l.) | 3 × 3 ml (1/2 - 3/4 L.) |
| 12-15 | 2-4 mau makahiki | 3 × 5 ml (1 l.) | 3 × 2,5 ml (1/2 lita). | 3 × 7.5 ml (1 1/2 l.) | 3 × 3.75 ml (3/4 l.) |
| 15-20 | 4-6 makahiki makahiki | 3 × 6.25 ml (1 1/4 l.) | 3 × 3 ml (1/2 - 3/4 L.) | 3 × 9.5 ml (1 3/4 -2 l.) | 3 × 5 ml (1 l.) |
| 20-30 | 6-10 mau makahiki | 3 × 8.75 ml (1 3/4 L.) | 3 × 4.5 ml (3/4 -1 l.) | - | 3 × 7 ml (1 1/4 -1 1/2 l.) |
| 30-40 | 10-12 mau makahiki | - | 3 × 6.5 ml (1 1/4 l.) | - | 3 × 9.5 ml (1 3/4 -2 l.) |
| ≥ 40 | ≥ 12 mau makahiki | Ua kuhikuhi ʻia ʻo Amoxiclav ® i nā papa | |||
ʻO ke kaulike i kēlā me kēia lā he hana no ka weheʻana o 400 mg + 57 mg / 5 ml i kau ka 1 kg o ke kino o ke kino ma muli o ka hōʻeha o ka maʻi a he 25-45 mg / kg kino kino lā / lā (ma nā huaʻōlelo o Nanixicillin), i hoʻokaʻawale ʻia i 2 dosis.
No ka hoʻomaʻamaʻa i nā dosa kūpono, ua kau ʻia kahi pēpē he 400 mg + 57 mg / 5 ml i kēlā me kēia paena o ka pipette dosage, hoʻopau ʻia i ka manawa like i ka 1, 2, 3, 4, 5 ml a me nā māhele like 4.
No ke ʻano o ka pohō ʻana o ka hoʻopiʻi ʻana ma muli o ke kino o ke keiki a me ka nui o ka maʻi.
| Kauka kino (kg) | Nā ʻōpio (kahi kokoke) | ʻO nā maʻi koʻikoʻi | Nā maʻi maʻi molo |
| 5-10 | 3-12 mahina | 2 × 2.5 ml (1/2 pipette) | 2 × 1.25 ml (1/4 pipette) |
| 10-15 | 1-2 mau makahiki | 2 × 3.75 ml (3/4 pipettes) | 2 × 2.5 ml (1/2 pipette) |
| 15-20 | 2-4 mau makahiki | 2 × 5 ml (1 pipette) | 2 × 3.75 ml (3/4 pipettes) |
| 20-30 | 4-6 makahiki makahiki | 2 × 7.5 ml (1 1/2 pipettes) | 2 × 5 ml (1 pipette) |
| 30-40 | 6-10 mau makahiki | 2 × 10 ml (2 pipettes) | 2 × 6.5 ml (1 1/4 pipettes) |
Hoʻoholo ʻia nā dole kūpono i kēlā me kēia lā ma ke paona o ke keiki, a ʻaʻole ʻo kona makahiki.
ʻO ka nui loa o ka lā ma amoxicillin o 6 g no nā pākeke, 45 mg / kg o ke kaumaha o ke kino no nā keiki.
ʻO ka nui loa o ka lā no clavulanic acid (ma ke ʻano o ka paʻakai pākela) he 600 mg no nā pākeke a me 10 mg / kg o ke kaumaha o ke kino no nā keiki.
I nā mea maʻi me ka maikaʻi o ka renal maikaʻi ʻole (CC ma mua o 10 ml / min), pono e hoʻemi ʻia ka nui a i ʻole ka palena ma waena o nā inikua ʻelua i hoʻonui ʻia (me anuria a hiki i 48 mau hola a keu paha).
ʻO ke ala e mālama ai i nā lā 5-14. Hoʻoholo ʻia ka lōʻihi o ke ʻano o ka mālama ʻana e ke kauka hele mai. ʻAʻole pono e hānai ʻia ʻoi aku ma mua o 14 mau lā me ka ʻole o kahi hoʻopaʻa loea.
Na rula no ka hoomakaukau ana o ka hoopanee ana
ʻO ka pauka no ka hoʻomākaukau ʻana o ka hoʻomaha o ka 125 mg + 31.25 mg / 5 ml: lulu ikaika i ka omole, hoʻohui iā 86 ml wai (i ka hōʻailona) i ʻelua mau pona, kēlā me kēia manawa e lulu pono a hiki i ka pau ʻana o ka pauka.
ʻO ka pauka no ka hoʻomākaukau ʻana o ka pohō o ka 250 mg + 62.5 mg / 5 ml: lulu ikaika i ka omole, hoʻohui i ka 85 ml wai (a hiki i ka māka) i ʻelua mau pona, i kēlā me kēia manawa e hiʻi maikaʻi a hiki i ka pau ʻana o ka pauka.
ʻO ka pauka no ka hoʻomākaukau ʻana o ka ʻaina o ka 400 mg + 57 mg / 5 ml: ikaika ikaika i ka hue, hoʻohui i ka wai i ka nui i hōʻike ʻia ma ke kāpili a hōʻike ʻia i ka papaʻaina (i ka hōʻailona) i ʻelua mau pona, i kēlā me kēia manawa e hiolo maikaʻi a hiki i ka pau ʻana o ka pauka.
| ʻOkoʻa nui | Ka mea e pono ai ka wai |
| 35 ml | 29.5 ml |
| 50 ml | 42 ml |
| 70 ml | 59 ml |
| 140 ml | 118 ml |
Ma mua o ka hoʻohana ʻana, pono e lulu nui ka kīʻaha.
Loaʻa ka hopena
ʻO nā hopena ʻaoʻao ma ka hapanui he mau māmā a transient.
Mai ka papa hana ʻana: ka nalo ʻana o ka momona, ka lua, ka luaʻi ʻana, ka ʻeha ʻana, ʻeha hōʻeha o ka ʻōpū, hōʻemi ʻia ka hana ʻana, a me ka hana o nā enzyme o ke ake (ALT a i AST), i nā hihia luhi - ʻo jaundice cholestatic, hepatitis, pseudomembranous colitis.
He maʻi kūlohelohe: itching, urticaria, erythematous rash, jarang - multiforme exudative erythema, angioedema, anaphylactic shock, vasculitis allergic, i nā hihia luhiluhi - dermatitis exfoliative, Stevens-Johnson syndrome, pomaula maʻamau ma ka maʻi exanthematous.
Mai ka pūnaehana hemopoietic a me ka ʻōnaehana lymphatic: luhi - leukopenia hoʻihoʻi (a me ke ʻano neutropenia), thrombocytopenia, ʻokoʻa loa - hemolytic anemia, hoʻoliʻi ka piʻi ʻana o ka manawa prothrombin (i hui pū ʻia me anticoagulants), eosinophilia, pancytopenia.
Mai ka pūnaehana pīhoihoi: dizziness, hōʻeha, ʻehaʻeha - nā hoʻohewa (hiki ke hele mai i ka mea maʻi me ka hana ʻana i nā mea ʻole a pau i ka wā i lawe ai i ka lāʻau i nā koina kiʻekiʻe), hyperactivity, hopohopo, hopohopo.
Mai ka pūnaehana urinary: līpoki loa - neʻeneʻe interstitial nephritis, crystalluria.
Nā mea ʻē aʻe: hiki ʻole - ka hoʻomohala ʻana i ka superinfection (me ka candidiasis).
Nā Hoʻohui
- hypersensitivity o kekahi o nā lāʻau o ka lāʻau,
- hypersensitivity i ka mōʻaukala i penicillins, cephalosporins a me nā antibiotika lika-lactam,
- ka mōʻaukala o nā hōʻike no ka jaundice cholestatic a me / a i ʻole nā hana ʻē aʻe i hoʻopilikia ʻia i kumu no ka lawe ʻana i ka acid amoxicillin / clavulanic,
- maʻi mononucleosis hopohopo a me ka maʻi lymphocytic.
Me ka mālama aka, pono ʻoe e hoʻohana i ka lāʻau lapaʻau me ka mōʻaukala o ka colitis pseudomembranous, me ka pale ole o ka nui, pilikia ʻole o ka mālamalama, a i ka wā o ka lactation.
Nā ʻōlelo kikoʻī
Me kahi papa o ka mālama ʻana, e nānā pono ʻia nā hana o ke koko, ka ate a me nā ʻōpū.
I nā mea maʻi me ka hana renal impaired koʻikoʻi, kūpono kahi hoʻoponopono ʻana i ka hoʻoponopono dosage a i ʻole ka nui aʻe o ke ana ma waena o ka dose e pono ai.
I mea e hōʻemi ai i ka hoʻopau ʻia o nā hopena ʻino mai ka gastrointestinal tract, pono ke lawe ʻia ka lāʻau lapaʻau me ka ʻai.
ʻO nā hoʻokolohua Laboratory: hāʻawi ʻoi i nā kiʻekiʻe ka maikaʻi o ka amoxicillin i ka hopena maikaʻi ʻole i ka glucose i ka wai i ka wā e hoʻohana ai i ka hopena o Benedict a i ʻole ka hopena o Felling. Hoʻomaopopo ʻia nā ʻano hopena Enzymatic me ka glucosidase.
Hoʻokomo i ka hiki ke lawe i nā kaʻa a kāohi i nā mīkini
ʻAʻohe ʻikepili e pili ana i ka hopena maikaʻi loa o Amoxiclav i nā makemake i ʻōlelo ʻia i ka hiki ke lawe i kahi kaʻa a hana paha me nā mīkini.
Ke keu
ʻAʻohe mau hōʻike e pili ana i ka make a i ke ola e pili ana i ka hopena ma muli o ka make nui o ka lāʻau.
Nā hōʻailona: ma ka nui o nā maʻi, nā maʻi o ka ʻeha gastrointestinal (ʻeha o ka ʻōpū, ʻeha, hoʻoheheʻe ʻia), ke ʻano hopohopo, ʻūhā, hiki i nā maʻi kuʻuna, i kekahi mau hihia hopu.
Hoʻomaʻamaʻa: pono ka mea maʻi ma lalo o ka mālama mālama olakino, maʻi therapy. Ma ka hihia o kēia hana o ka lāʻau lapaʻau (ma mua o 4 mau hola) pono ia e holoi i ka ʻōpū a hoʻonā i nā ulana i hoʻolaʻa ʻia e hōʻemi ai i ka lilo ʻana o ka lāʻau. Hoʻokuʻuʻia ka amoxicillin / potassium clavunate e ka hemodialysis.
Hoʻokiʻokiʻo Amoxiclav - nā ʻōlelo i hoʻohana ʻia ai
ʻO nā mea maikaʻi o nā lāʻau lapaʻau i hāʻawi iā ia i kahi inoa no kahi lapaʻau kūpono e kū'ē i nā haneli o nā maʻi. Hana ʻia ʻo Amoxiclav e ka alakaʻi ʻana i nā kauka ma Lūkini a me nā ʻāina CIS ʻē aʻe. Eia naʻe, inā hoʻohana pono ʻole, hiki i ka lāʻau lapaʻau ke hōʻeha i ke kino o ke kanaka. I mea e pale ai i kēlā mau hewa, ma mua o ka hoʻomaka ʻana i ka mālama ʻana, e heluhelu ʻōlelo pinepine i nā ʻōkuhi a nīnau aku i kahi kauka.
ʻO nā mea ikaika o ka lāʻau, hāʻawi i kahi hopena antibacterial - amoxicillin a me clavulanic acid. Hāpai kēia mau māhele i ka ulu a me ka hana o nā mea pono kino.Hoʻohui iā lākou, aia kahi kikoʻī i kahi ʻāpana o nā mea kōkua aʻaila e loaʻa ai ka maikaʻi o ke kōpana ʻana o ka lāʻau e ka poʻe kanaka:
- kaomi citric acid,
- sodium carmellose
- colloidal silicon dioxide,
- sodium saccharin
- hika sodium lemu,
- mikuleka
- laulaja popula
- sodium benzoate
- silika
- mannitol
- nā hāmeʻa (lemon, ka ʻōpala, ka huaʻai).
Pharmacodynamics a me ka pharmacokinetics
Hoʻomaʻaʻa ʻia ka lāʻau lapaʻau e kūʻē i kahi ākea he nui o nā microorganisms:
- aerobic gram-maikaʻi a me nā pali-gram maikaʻi ʻole,
- anaerobic gram-positive and gram-negative bacteria,
- Nā momo beta-lactamase II, III, IV, V (subspecies o kēia mau microorganism i kūʻokoʻa i ka amoxicillin e luku pau ʻia e ka lua ikaika hana - clavulanic acid).
Ma hope o ka lawe ʻana i ka pona ʻana, i loko o nā mea ikaika a Amoxiclav e hopu koke i nā membed mucous o ka gastrointestinal tract. ʻO ka hoʻohana ʻana i ka ʻai me ka mea ʻole e hoʻemi i ka inu ʻana, a no laila, ʻaʻohe mea pono ke kū i ka hoʻomaha a ma mua a ma hope o ka ʻai ʻana. ʻO ka manawa e hiki ai i ka lōʻihi loa o ke kūkaʻi clavulanic acid a me ka amoxicillin e pili ana i 45 mau minuke. Kumuhana i ka dosis i kuhikuhi ʻia e ke kauka, ʻaʻole ka hōʻino i ka mālama ʻana i ke kino. ʻO nā huahana break Amoxicillin e hoʻopili ʻia mai ke kino ma loko o nā lā 10-15.
Nosological ʻano papa (ICD-10)
| Nā papa hana ʻulaʻī | 1 kōpō. |
| nā mea waiwai (core): | |
| amoxicillin (i ke ʻano o kahi trihydrate) | 250 mg |
| kaʻiole clavulanic (ma ke ʻano o ka paʻakai paʻakai) | 125 mg |
| nā mea hoʻowalewale: ʻO ke kiko silika colloidal - 5.4 mg, crospovidone - 27,4 mg, criumarmellose sodium - 27.4 mg, magnesium stearate - 12 mg, talc - 13.4 mg, MCC - a hiki i ka 650 mg | |
| make a film hypromellose - 14.378 mg, ethyl cellulose 0.702 mg, polysorbate 80 - 0.78 mg, triethyl citrate - 0.793 mg, titanium dioxide - 7.605 mg, talc - 1.742 mg |
| Nā papa hana ʻulaʻī | 1 kōpō. |
| nā mea waiwai (core): | |
| amoxicillin (i ke ʻano o kahi trihydrate) | 500 mg |
| kaʻiole clavulanic (ma ke ʻano o ka paʻakai paʻakai) | 125 mg |
| nā mea hoʻowalewale: colloidal silicon dioxide - 9 mg, crospovidone - 45 mg, sodium croscarmellose - 35 mg, magnesium stearate - 20 mg, MCC - a hiki i 1060 mg | |
| make a film hypromellose - 17.696 mg, ethyl cellulose - 0.864 mg, polysorbate 80 - 0.96 mg, triethyl citrate - 0.976 mg, titanium dioxide - 9.36 mg, talc - 2.144 mg |
| Nā papa hana ʻulaʻī | 1 kōpō. |
| nā mea waiwai (core): | |
| amoxicillin (i ke ʻano o kahi trihydrate) | 875 mg |
| kaʻiole clavulanic (ma ke ʻano o ka paʻakai paʻakai) | 125 mg |
| nā mea hoʻowalewale: colloidal silicon dioxide - 12 mg, crospovidone - 61 mg, sodium croscarmellose - 47 mg, magnesium stearate - 17.22 mg, MCC - a hiki i 1435 mg | |
| make a film hypromellose - 23.226 mg, ethyl cellulose - 1.134 mg, polysorbate 80 - 1.26 mg, triethyl citrate - 1.28 mg, titanium dioxide - 12.286 mg, talc - 2.814 mg |
| ʻO ka pauka no ka pohō ʻana i ka waha | 5 ml lolo |
| mea waiwai: | |
| amoxicillin (i ke ʻano o kahi trihydrate) | 125 mg |
| kaʻiole clavulanic (ma ke ʻano o ka paʻakai paʻakai) | 31.25 mg |
| nā mea hoʻowalewale: citric acid (anhydrous) - 2.167 mg, sodium citrate (anhydrous) - 8.335 mg, sodium benzoate - 2.085 mg, MCC a me ka sodium carmellose - 28.1 mg, xanthan gum - 10 mg, colloidal silicon dioxide - 16.667 mg, silicon dioxide - 0.217 g, sodium saccharinate - 5.5 mg, mannitol - 1250 mg, ʻōpala ʻōpala - 15 mg |
| ʻO ka pauka no ka pohō o ka waha | 5 ml lolo |
| mea waiwai: | |
| amoxicillin (i ke ʻano o kahi trihydrate) | 250 mg |
| kaʻiole clavulanic (ma ke ʻano o ka paʻakai paʻakai) | 62.5 mg |
| nā mea hoʻowalewale: citric acid (anhydrous) - 2.167 mg, sodium citrate (anhydrous) - 8.335 mg, sodium benzoate - 2.085 mg, MCC a me ka sodium carmellose - 28.1 mg, xanthan gum - 10 mg, colloidal silicon dioxide - 16.667 mg, silicon dioxide - 0.217 g, sodium saccharinate - 5.5 mg, mannitol - 1250 mg, wild cherry flavor - 4 mg |
| ʻO ka pauka no ka pohō o ka waha | 5 ml lolo |
| mea waiwai: | |
| amoxicillin (i ke ʻano o kahi trihydrate) | 400 mg |
| kaʻiole clavulanic (ma ke ʻano o ka paʻakai paʻakai) | 57 mg |
| nā mea hoʻowalewale: citric acid (anhydrous) - 2.694 mg, sodium citrate (anhydrous) - 8.335 mg, MCC a me ka carmellose sodium - 28.1 mg, xanthan gum - 10 mg, colloidal silicon dioxide - 16.667 mg, silicon dioxide - 0.217 g, wild cherry flavor - 4 mg, ka lemona lemon - 4 mg, sodium saccharinate - 5.5 mg, mannitol - a hiki i 1250 mg |
| ʻO ka paukahi no ka hoʻonā ʻana no ka hoʻokele intravenous | 1 fl. |
| mea waiwai: | |
| amoxicillin (i ke ʻano o ka paʻakai sodium) | 500 mg |
| kaʻiole clavulanic (ma ke ʻano o ka paʻakai paʻakai) | 100 mg |
| ʻO ka paukahi no ka hoʻonā ʻana no ka hoʻokele intravenous | 1 fl. |
| mea waiwai: | |
| amoxicillin (i ke ʻano o ka paʻakai sodium) | 1000 mg |
| clavulanic acid (ma ke ʻano o ka paʻakai pākela). | 200 mg |
| Nā pale papa | 1 kōpō. |
| mea waiwai: | |
| amoxicillin trihydrate | 574 mg |
| (e like me 500 mg o ka amoxicillin) | |
| pā clavulanate | 148.87 mg |
| (e like me 125 mg o ka clavulanic acid) | |
| nā mea hoʻowalewale: Ka hoʻohuihiwa pōpilikia - 26 mg, ka ʻono ʻono i ka wai - 26 mg, aspartame - 6,5 mg, colloidal silicon dioxide anhydrous - 13 mg, hao (III) oxide melemele (E172) - 3.5 mg, talc - 13 mg, castor nā ʻaila hydrogenated - 26 mg, silikino-me MCC - a hiki i 1300 mg |
| Nā pale papa | 1 kōpō. |
| mea waiwai: | |
| amoxicillin trihydrate | 1004.50 mg |
| (e like me 875 mg o ka amoxicillin) | |
| pā clavulanate | 148.87 mg |
| (e like me 125 mg o ka clavulanic acid) | |
| nā mea hoʻowalewale: Ka hoʻohuihui pōpilikia - 38 mg, ka ʻono ʻono i ka wai - 38 mg, aspartame - 9.5 mg, colloidal silicon dioxide anhydrous - 18 mg, hao (III) oxide melemele (E172) - 5.13 mg, talc - 18 mg, castor nā ʻaila hydrogenated - 36 mg, silicon-piha MCC - i ka 1940 mg |
Nā hōʻailona no ka hoʻohana ʻana
Hoʻomaopopo ʻia ka pauma Amoxiclav i nā hihia i kahi pono e hakakā i nā maʻi i hoʻoiho ʻia e nā microorganisms o nā kānana pono. E pili ana kēia:
- nā hopena o ka ʻōpū hanu o luna a me nā mea komo ENT (ke kumu a me ka sinusitis aʻalolo, abscess pharyngeal, pharyngitis, tonsillitis, otitis media),
- nā maʻi lēpa o ka ʻōpū o ka hanu haʻahaʻa (ʻoi o ke ʻano o ka bronchitis me kahi mea o ka hoʻoulu ʻana o nā maʻi bacterial, pneumonia, etc.),
- maʻi maʻi gynecological
- maʻi maʻi maʻi urinary
- nā maʻi ʻili o ka ʻili a me nā ʻano hoʻohui,
- nā iwi ʻōpala a me nā maʻi hōʻiliʻili (me nā hua o ke kanaka a me nā holoholona),
- maʻi maʻi odontogenic
- biliary tract infection (cholangitis, cholecystitis).
ʻO ka wehewehe ʻana i ke ʻano dosis
250 + 125 mau papa pā: ke keʻokeʻo a ʻokoʻa paha keʻokeʻo paha, oblong, octagonal, biconvex, film-coated, me nā paʻi ʻana o "250/125" ma kekahi ʻaoʻao a me "AMC" ma kēlā ʻaoʻao.
500 + 125 mg papa: keʻokeʻo a ʻokoʻa paha keʻokeʻo, ʻānō, biconvex, film-coated.
Nā Papa 875 + 125 mg: ke keʻokeʻo a ʻokeʻoke paha keʻokeʻo paha, oblong, biconvex, kāwele ʻia, ʻoniʻoni me nā panina a me nā manaʻo "875" a me "125" ma kekahi ʻaoʻao a me "AMC" ma kēlā ʻaoʻao.
Ka nānā ʻana i kahi kink: kaomi melemele.
ʻO ka pauku no ka pohō ʻana i ka waha: pauka mai keʻokeʻo a hiki i keʻokeʻo keʻokeʻo. ʻO ka pēpē i pau nei he hana hoʻoneʻe homogeneous mai kahi keʻokeʻo a keʻokeʻo.
ʻO ka pauka no ka hoʻomākaukau ʻana i kahi hopena no ka ʻoila iv: mai keokeo a hiki i keʻokeʻo ke ʻano.
Loaʻa nā papa ʻaina: oblong, octagonal, ʻulaʻula kukui me kahi ulana o kahi ʻulaʻula, me kahi manamana fruity.
ʻŌpū a me ka lactation
I ka wā hāpai a me ka lactation, ke hoʻohana wale ʻia ʻo Amoxiclav ® inā pono ka pōmaikaʻi i manaʻo ʻia i ka makuahine ma mua o ka nui o ka hiki i ka pūpū a me ke keiki.
Hiki ke kuhikuhi ʻia ʻo Amoxiclav ® Quicktab i ka wā hāpai a inā he mau ʻike maopopo.
ʻO Amoxicillin a me clavulanic acid i kahi liʻiliʻi liʻiliʻi e komo i loko o ka waiū umauma.
Nā hopena hopena
ʻO nā papa kiʻi ʻoniʻoni ʻo Amoxiclav ® a me ka pauka no ka hoʻomākaukau ʻana i kahi hoʻonā no ka hoʻokō iv
Mai ka pūnaehana hana ʻana: ka nalo ʻana o ka ʻono, ka ʻōpū, ka luaʻi ʻana, ka ʻeha o ka ʻōpū, ka ʻōpū, ka hōʻeha, ka leʻomaʻi, ka glossitis, ʻulaʻula "lauoho", ʻeleʻele o ka enamel niho, colitis hemorrhagic (e ulu pū ka hope ma hope o ka lāʻau), enterocolitis, pseudomembranous colitis, hana ʻole i ka hana ate, hoʻonui ʻia ALT, AST, ka phosphatase alkaline a me / a i ʻole nā pae bilirubin plasma, hōʻeha o ka ate (ʻoi aku ka nui i ka poʻe ʻelemakule, nā kāne, me ka hoʻomanawanui lōʻihi), ʻo ka jaundice cholestatic, hepatitis.
Nā maʻi kūwaha: pruritus, urticaria, erythematous rashes, erythema multiforme exudative, angioedema, anaphylactic shock, allergic vasculitis, exfoliative dermatitis, Stevens-Johnson syndrome, ulana maoli exanthematous pustulosis, he ʻāhane e like me ka maʻi serum, epidermis toxic.
Mai ka pūnaehana hemopoietic a me ka ʻōnaehana lymphatic: leukopenia hiki mai (me ka neutropenia), thrombocytopenia, hemolytic anemia, hoʻololi hou ʻia i ka PV (i ka wā i hoʻohana pū ʻia me anticoagulants), hoʻonui ʻia i ka manawa koko, eosinophilia, pancytopenia, thrombocytosis, agranulocytosis.
Mai ka ʻaoʻao o ka pīkī laha waena: dizziness, headache, convulsions (hiki i nā mea maʻi me ka hana renal impaired i ka wā a lawe i nā kiʻekiʻe kiʻekiʻe o ka lāʻau).
Mai ka urinary system: interstitial nephritis, crystalluria, hematuria.
Nā ʻili: kandidiasis a me nā ʻano ʻē aʻe o ka superinfection.
No nā papa hana ʻoniʻoni polū, ka pauka no ka hoʻopiʻi ʻana i ka waha, ka pauka no ka hoʻonā o nā waha ma kahi o ka pane ʻana
Mai ka ʻaoʻao o ka pīkī laha waena: pālahalahaʻai. Fehe o ka hopohopo, lokoʻa, loli, hoʻāla.
ʻO Amoxiclav ® Quicktab a me ka pauka me Amoxiclav ® no ka hoʻokuʻu ʻana i ka waha
Mai nā ʻekopa hemopoietic a me ka ʻōnaehana lymphatic: leukopenia līwī (hiki i ke neutropenia), thrombocytopenia, loa pinepine - eosinophilia, thrombocytosis, hiki i ka agranulocytosis, hiki ke hoʻonui i ka manawa koko a me ka piʻi hou i loko o PV, anemia, a me hoʻohālikelike hemolytic anemia.
Mai ka pānaʻi: ʻike pinepine ʻole ka frequency - angioedema, reaksi anaphylactic, vasculitis allergic, he ʻeha e like me ka maʻi serum.
Mai ka ʻōnaehana hoʻonāukiuki: - ka ʻeha, ka poʻomanaʻo, ʻehaʻeha - hikiʻole i ka insomnia, ke kaumaha, hopohopo, hoʻoweliweli, hoʻololi ʻana, hoʻāla ʻia ka hoʻōla, hoʻoliʻi, hiki i ka hoʻokau ʻana ke hele i nā maʻi me ka hana ʻole, a me ka poʻe e loaʻa nā kaha kiʻekiʻe o ka lāʻau lapaʻau.
Mai ka palaki kuʻekuʻe: pinepine - ka nalowale i ka makemake, nilo, ka luaʻi ʻana, ka ʻeha ʻana o ka maʻi. ʻIke pinepine ʻia ke ʻano loiloi i ka wā e kau ai nā kaha kiʻekiʻe. Inā hoʻopaʻa ʻia nā maʻi gastrointestinal, hiki ke hoʻopau ʻia inā ke lawe ʻia ka lāʻau i ka hoʻomaka ʻana o ka pāʻina, pinepine - hoʻoweliweli ka huhū, ʻike pinepine ʻia nā maʻi o ka antibiotic e hoʻoulu ʻia e ka antibiotics (me ka pseudomembranous a me ka hemorrhagic colitis), nā lehelehe ʻeleʻele, gastritis stomatitis. I nā keiki, ʻike liʻiliʻi ka ʻili o ka papale papa o ka niho enamel. E mālama ana ka mālama waha i ka pale ʻana i ka enamel niho.
Ma ka ʻāpana o ka ʻili. ka pinepine - ka ʻāʻī o ka ʻili, ka huhū, ka urticaria, līkeke - erythema e ka multiforme exudative, ʻike pinepine ʻole - Stevens-Johnson syndrome, necrolysis epidermal toxic, ʻekahi dermatitis exousoli, ulu exanthematous pustulosis.
Mai ka urinary system: loa iino loa - crystalluria, interstitial nephritis, hematuria.
Ma ka ʻāpana o ka ate a me ka pēpē biliary: pinepine - i hoʻonui ʻia ka hana o ALT a me / a AST (ʻike ʻia kēia ʻike ʻana i nā mea maʻi e loaʻa ana i ka hoʻomehana maʻi beta-lactam, akā ʻike ʻia kona ʻano koʻikoʻi), ʻO nā hanana ʻino mai ka luhi e nānā nui ʻia i nā kāne a me nā mea maʻi a hiki i ka pili paha me ka lōʻihi o ka maʻi. ʻO nā hanana ʻino loa i nānā ʻole i nā keiki.
ʻO nā hōʻailona a me nā hōʻailona i hele pinepine ʻia ma ke a ma hope iho o ka pau ʻana o ka hoʻōla, eia naʻe i kekahi mau hihia ʻaʻole paha e ʻike ʻia no kekahi mau hebedoma ma hope o ka pau ʻana o ka lapaʻau. ʻO nā hanana ʻinoʻino ke hoʻololi pinepine ʻia. Hiki i nā pilikia hōʻeha mai ka luhi ka maʻi paʻakikī, ma nā hihia koʻikoʻi loa i hōʻike ʻia nā hopena o nā hopena hōʻeha. I ka aneane āpau, ʻo kēia mau mea maʻi me ka pathology concomitant koʻikoʻi a i ʻole nā mea maʻi e loaʻa ana i nā lāʻau lapaʻau hepatotoxic. Kuhi iki ʻole - hoʻonui i ka hana o ka phosphatase alkaline, hoʻonui bilirubin, hepatitis, jaundice cholestatic (ʻike ʻia me ka concomitant therapy me nā penicillins a me cephalosporins).
Nā ʻili: pinepine - kandidiasis o ka ʻili a me nā membrane mucous, ʻaʻole maopopo ka ʻike i ke ala - ka ulu ʻana o nā microorganisms insensitive.
Hoʻohui
No nā palapala hoʻoponopono āpau
Hoʻokomo i nā hoʻonaninani, nā glucosamine, laxatives, aminoglycosides i ka hoʻopili ʻana aku, hoʻonui i ka hoʻohuihui ascorbic.
Diuretics, allopurinol, phenylbutazone, NSAIDs a me nā lāʻau lapaʻau ʻē aʻe e kāohi ana i ka huna ʻana o tubular (probenecid) e hoʻonui i ka kūpaʻa o ka amoxicillin (clavulanic acid e hoʻōla nui ʻia e ka glomerular filtration).
ʻO ka hoʻohana like ʻana o ka Amoxiclav ® a me ka methotrexate e hoʻonui i ka pakanā o methotrexate.
Hoʻohui ka koho me ka allopurinol hoʻonui i ka ulu ʻana o ka exanthema. ʻO ka hoʻohana pono ʻana me ka disulfiram e hōʻalo.
Hoʻemi i ka hopena o nā lāʻau lapaʻau, i ka wā o ka hana o ka metabolism i hana ai ʻo PABA, ethinyl estradiol - ka loaʻa aʻe o ke kahe pohō.
Hōʻike ka puke puke i nā hihia lihua o ka hoʻonui ʻana i ka INR i nā mea maʻi me ka hoʻohana pū ʻana o acenocumarol a i ʻole warfarin a me amoxicillin. Inā kūpono, hoʻohana pinepine ʻia me nā anticoagulants, pono e kiaʻi pono ʻia ʻo PV a me INR i ka wā i kuhikuhi ai a i ʻole ke hoʻopau i ka lāʻau.
ʻO ka hui pū me ka rifampicin he antagonistic (palupalu palupalu o ka hopena antibacterial). ʻAʻole pono e hoʻohana ʻo Amoxiclav ® i ka manawa like me ka hui pū me nā antibiotika bacteriostatic (macrolides, tetracyclines), sulfonamides ma kahi o kahi hiki ke emi i ka hopena o Amoxiclav ®.
Hoʻopiliʻo Amoxiclav ® i ka hopena o nā mea hoʻohālikelike waha.
No ka papa aku i nā papa ʻaila a me nā pauka no ka hoʻopanee ʻana i ka hoʻoponopono waha
Hoʻonui i ka hopena o ka anticoagulants kūpaʻa (ke kāohi ʻana i ka microflora pono o ka ʻōpū, hōʻemi i ka hoʻāla ʻana o ka vitamina K a me ka ʻōlelo prothrombin). I kekahi mau hihia, lawe i ka lāʻau lapaʻau e hiki ke hoʻonui i ka PV, ma kēia hana, pono e mālama ʻia i ka wā e hoʻohana ana i ka anticoagulants a me ka lāʻau lapaʻau Amoxiclav ® Quicktab.
Hoʻopala ka Probenecid i ka hoʻonuiʻana i ka amoxicillin, e hoʻonui ana i kona koʻikoʻi serum.
I ka poʻe maʻi e loaʻa ana i ka mycophenolate mofetil, ma hope o ka hoʻomaka ʻana o ka hoʻohana ʻana o ka hui o ʻoxxillillin me ka clavulanic acid, kahi hōʻemi i ka ʻike ʻana o ka metabolite ikaika, ka waika mycophenolic, ua nānā ʻia ma mua o ka lawe ʻana i ka hā aʻe o ka lāʻau i ka aneane 50%. ʻAʻole hiki i nā loli i loko o kēia neʻe ʻana i nā loli maʻamau i ka hoʻolaha ʻana o ka waila mycophenolic.
No ka pauku no ka hoʻomākaukau o kahi hopena no ka mālama ʻo iv
ʻO Amoxiclav® a me nā antibiotics aminoglycoside i kūleʻa hoʻohālikelike.
Mai hoʻohui iā Amoxiclav ® i kahi syringe a i ʻole infusion vial me nā lāʻau ʻē aʻe.
Hōʻalo i ka hoʻohui ʻana me nā mea hoʻonā o nā dextrose, dextran, sodium bicarbonate, a me ka hoʻonā ʻana i nā koko, nā protein, nā lipids.
Hoʻohui nūhou
Me ka hoʻohana like ʻana o ka lāʻau Amoxiclav ® me nā antacids, glucosamine, laxatives, aminoglycosides, hoʻopihapiha ʻia nā kīmole me ka waika ascorbic - hoʻonui.
Diuretics, allopurinol, phenylbutazone, NSAIDs a me nā lāʻau lapaʻau ʻē aʻe e poloka ana i ka ʻōlelo huna tubular e hoʻonui i ka pehu o ka amoxicillin (clavulanic acid e hoʻōla nui ʻia e ka glomerular filtration).
Me ka hana like o Amoxiclav ® e hoʻonui i ka pehu o ka methotrexate.
Me ka hoʻohana like ʻana o Amoxiclav me allopurinol, ke hoʻonui nui nei ka ulu o ka exanthema.
ʻO ka hui lawelawe me ka disulfiram e hōʻalo.
I kekahi mau mea, lawe ka lāʻau lapaʻau e hiki ke hoʻolōʻihi i ka manawa prothrombin, i kēia mea, pono e hoʻomaʻamaʻa ʻia i ka wā e kuhikuhi ana i nā anticoagulants a me ka lāʻau lapaʻau Amoxiclav ®.
ʻO ka hui pū ʻana o ka amoxicillin me rifampicin he antagonistic (aia kekahi mauwaliwali ʻana o ka hopena antibacterial).
ʻAʻole pono e hoʻohana ʻo Amoxiclav ® i ka manawa like me nā antibiotika bacteriostatic (macrolides, tetracyclines), sulfonamides ma kahi o kahi hiki ke emi i ka hopena o Amoxiclav.
Hoʻopala ka Probenecid i ka hoʻonuiʻana i ka amoxicillin, e hoʻonui ana i kona koʻikoʻi serum.
Hoʻemi ka poʻe antibiotics i ka hopena o nā mea hoʻohālikelike waha.
ʻLoe a me ke kākele
Nā papa hana ʻulaʻī
I loko. Hoʻonohonoho ʻia ka nui o ka dosage ma ke ʻano, he pili i ka makahiki, ke kino o ke kino, ke ʻano o ka hana o ka mea maʻi, a me ka nui o ka maʻi.
Hoʻomaopopo ʻia ʻo Amoxiclav ® e lawe i ka hoʻomaka ʻana o ka ʻai no ka maikaʻi o ke komo ʻana a hiki i ka hoʻēmi ʻana i nā hopena hopena mai ka kūnaʻi ʻana.
ʻO ke ala e mālama ai i nā lā 5-14. Hoʻoholo ʻia ka lōʻihi o ke ʻano o ka mālama ʻana e ke kauka hele mai. ʻAʻole pono e hānai ʻia ʻoi aku ma mua o 14 mau lā me ka ʻole o kahi hoʻopaʻa loea.
E kau ʻia ka ʻōhua ma muli o ke ʻano a me ke kaumaha o ke kino. ʻO ka regimen dosis papa ʻia ʻo 40 mg / kg / lā ma 3 mau māhele i hoʻokaʻawale.
ʻO nā keiki me ka paona o ke kino he 40 kg a ʻoi aku paha e hāʻawi ʻia i nā pā kau like i nā pākeke. No nā keiki i ≤6 mau makahiki, ʻoi aku ka maikaʻi o ka lawe ʻana mai iā Amoxiclav ®.
ʻO nā pākeke a me nā keiki ma mua o 12 mau makahiki (a> 40 kg o ke kino kino)
ʻO ka maʻi maʻamau ma ka hihia o ka maʻi maʻamau a hōʻemi ʻia nā papa ʻaina. 250 + 125 mg i kēlā me kēia 8 mau hola a i ʻole 1 papa papaʻa. 500 + 125 mg i kēlā me kēia mau hola 12, ma ke ʻano o nā maʻi koʻikoʻi a me nā maʻi i ka hanu - 1 papa. 500 + 125 mg i kēlā me kēia 8 mau hola a i ʻole 1 papa papaʻa. 875 + 125 mg i kēlā me kēia 12 hola
No ka mea ke hui pū ʻia nā papa ʻo amoxicillin a me clavulanic acid 250 + 125 mg a me 500 + 125 mg kēlā me kēia nui i ka nui o ka clavulanic acid - 125 mg, a laila 2 papa. ʻO 250 + 125 mg ʻaʻole like ia me 1 papa. 500 + 125 mg.
ʻO nā heluʻai no nā maʻi odontogenic
1 kōpō. 250 + 125 mg i kēlā me kēia 8 mau hola a i ʻole 1 papa papaʻa. 500 + 125 mg i kēlā me kēia mau hola 12 no 5 mau lā.
ʻO ka maʻi me ka hana renal impaired
Kuhi ʻia ka hoʻoponopono ʻana i ka dosis me ka nui loa o ke ʻano loiloi ʻo amoxicillin a lawe ʻia i nā waiwai Cl Clininine:
- nā ʻōpio a me nā keiki i ʻoi aku ma mua o 12 mau makahiki (a i ʻ kg40 kg paha o ka paona kino) (papaʻaina
- me anuria, ka nui ma waena o nā kikoiki e hoʻonui ʻia i 48 mau hola a keu paha.
Hoʻohana pono ʻia - 875 + 125 mg papa i nā mea maʻi me ka Cl creatinine> 30 ml / min.
| Hoʻolaha ʻo Creinine | Ka lula ʻaʻoma Amoxiclav ® |
| > 30 ml / min | ʻAʻole koi ke hoʻoponopono ʻia |
| 10-30 ml / min | 1 kōpō. 50 + 125 mg 2 mau manawa i kahi lā a i ʻole 1 papa. 250 + 125 mg (me ka maʻi maʻalahi o ka maʻi mau) 2 mau manawa i kahi lā |
| E hoʻokō ʻia ka hana me ka akahele. Pono ke nānā pono ʻana i nā hana ate. |
ʻO ka pauka no ka pohō o ka waha
ʻO nā lā hoʻomaha o kēlā me kēia lā he 125 + 31.25 mg / 5 ml a me 250 + 62.5 mg / 5 ml (e kālama i nā hōkū kūpono, i kēlā me kēia pākeke o nā pona 125 + 31.25 mg / 5 ml a me 250 + 62.5 mg / 5 ml, he pipette puka mua o 5 ml me kahi mākaukau 0.1 ml a i ʻole ka pā kīpē 5-ml me nā hōʻailona annular i ka ana o 2.5 a me 5 ml).
ʻO nā keiki a me nā keiki a hiki i 3 mau mahina - 30 mg / kg / lā (e like me ke amoxicillin), i māhele ʻia i 2 mau pona (ʻo kēlā me kēia mau hola 12).
Ka make ʻana o ka lāʻau Amoxiclav ® me kahi pipette dosing - ke helu helu ʻana i nā wai kū hoʻokahi no ka mālama ʻana i nā maʻi i nā pēpē a me nā keiki i nā keiki 3 a hiki i ka 3 mau papa (Papa 3).
| Kau ka paona | 2 | 2,2 | 2,4 | 2,6 | 2,8 | 3 | 3,2 | 3,4 | 3,6 | 3,8 | 4 | 4,2 | 4,4 | 4,6 | 4.8 |
| Hoʻopaʻa 156.25 ml (mau manawa 2 i ka lā) | 1,2 | 1,3 | 1,4 | 1,6 | 1,7 | 1,8 | 1,9 | 2 | 2,2 | 2,3 | 2,4 | 2,5 | 2,6 | 2,8 | 2,9 |
| Hoʻopaʻa 312.5 ml (2 mau manawa i ka lā) | 0,6 | 0,7 | 0,7 | 0,8 | 0,8 | 0,9 | 1 | 1 | 1,1 | 1,1 | 1,2 | 1,3 | 1,3 | 1,4 | 1,4 |
ʻOi aku nā keiki ma mua o 3 mahina - mai 20 mg / kg no ka maʻi o ka hōʻemi i ka hōʻemi a i ka hoʻohaʻahaʻa i ka 40 mg / kg no nā maʻi koʻikoʻi a me nā maʻi o ka hanu haʻahaʻa, otitis media, sinusitis (amoxicillin) i kēlā me kēia lā, i hoʻokaʻawale ʻia i 3 mau pona (i kēlā me 8 mau hola).
Ka make ʻana o ka lāʻau Amoxiclav ® me ka pipette dosing - ke helu helu ʻana i nā wai kū hoʻokahi no ka mālama ʻana i nā maʻi haʻahaʻa a me ke ʻano i nā keiki ʻoi aku ka 3 mau mahina (e pili ana i 20 mg / kg / lā (no ka amoxicillin) (Papa 4).
| Kau ka paona | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 |
| Hoʻopaʻa 156.25 ml (3 mau lā i ka lā) | 1,3 | 1,6 | 1,9 | 2,1 | 2,4 | 2,7 | 2,9 | 3,2 | 3,5 | 3,7 | 4 | 4,3 | 4,5 | 4,8 | 5,1 | 5,3 | 5,6 | 5,9 |
| Hoʻopaʻa 312.5 ml (3 mau manawa i ka lā) | 0,7 | 0,8 | 0,9 | 1,1 | 1,2 | 1,3 | 1,5 | 1,6 | 1,7 | 1,9 | 2 | 2,1 | 2,3 | 2,4 | 2,5 | 2,7 | 2,8 | 2,9 |
| Kau ka paona | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | |
| Hoʻopaʻa 156.25 ml (3 mau lā i ka lā) | 6,1 | 6,4 | 6,7 | 6,9 | 7,2 | 7,5 | 7,7 | 8 | 8,3 | 8,5 | 8,8 | 9,1 | 9,3 | 9,6 | 9,9 | 10,1 | 10,4 | |
| Hoʻopaʻa 312.5 ml (3 mau manawa i ka lā) | 3,1 | 3,2 | 3,3 | 3,5 | 3,6 | 3,7 | 3,9 | 4 | 4,1 | 4,3 | 4,4 | 4,5 | 4,7 | 4,8 | 4,9 | 5,1 | 5,2 |
Ka make ʻana o ka lāʻau Amoxiclav ® me ka pipette dosage - ke helu helu ʻana i nā helu kū hoʻokahi no ka mālama ʻana i nā maʻi ʻino loa i nā keiki ʻoi aku ka 3 mau mahina (e pili ana i ka 40 mg / kg / lā (no ka amoxicillin) (Papa 5).
| Kau ka paona | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 |
| Hoʻopaʻa 156.25 ml (3 mau lā i ka lā) | 2,7 | 3,2 | 3,7 | 4,3 | 4,8 | 5,3 | 5,9 | 6,4 | 6,9 | 7,5 | 8 | 8,5 | 9,1 | 9,6 | 10,1 | 10,7 | 11,2 | 11,7 |
| Hoʻopaʻa 312.5 ml (3 mau manawa i ka lā) | 1,3 | 1,6 | 1,9 | 2,1 | 2,4 | 2,7 | 2,9 | 3,2 | 3,5 | 3,7 | 4 | 4,3 | 4,5 | 4,8 | 5,1 | 5,3 | 5,6 | 5,9 |
| Kau ka paona | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | |
| Hoʻopaʻa 156.25 ml (3 mau lā i ka lā) | 12,3 | 12,8 | 13,3 | 13,9 | 14,4 | 14,9 | 15,5 | 16 | 16,5 | 17,1 | 17,6 | 18,1 | 18,7 | 19,2 | 19,7 | 20,3 | 20,8 | |
| Hoʻopaʻa 312.5 ml (3 mau manawa i ka lā) | 6,1 | 6,4 | 6,7 | 6,9 | 7,2 | 7,5 | 7,7 | 8 | 8,3 | 8,5 | 8,8 | 9,1 | 9,3 | 9,6 | 9,9 | 10,1 | 10,4 |
Ka make ʻana o ka lāʻau Amoxiclav ® me kahi wai dosage (i ka ʻike ʻole ʻana o ka pipette dosage) - ke ʻano o ka ʻōkuhi i hāpai ʻia e kau ana ma muli o ke kaumaha o ke keiki a me ka uha o ka maʻi (Papa 6).
| Kau ka paona | Nā ʻōpio (kahi kokoke) | ʻ courselelo haʻahaʻa / moderate | Kūʻai koʻikoʻi | ||
| 125 + 31.25 mg / 5 ml | 250 + 62.5 mg / 5 ml | 125 + 31.25 mg / 5 ml | 250 + 62.5 mg / 5 ml | ||
| 5–10 | 3-12 mahina | 3 × 2,5 ml (½ punela) | 3 × 1.25 ml | 3 × 3.75 ml | 3 × 2 ml |
| 10–12 | 1-2 mau makahiki | 3 × 3.75 ml | 3 × 2 ml | 3 × 6.25 ml | 3 × 3 ml |
| 12–15 | 2–4 makahiki | 3 × 5 ml (1 kele) | 3 × 2,5 ml (½ punela) | 3 × 7.5 ml (1½ punetēl) | 3 × 3.75 ml |
| 15–20 | 4-6 makahiki makahiki | 3 × 6.25 ml | 3 × 3 ml | 3 × 9.5 ml | 3 × 5 ml (1 kele) |
| 20–30 | 6-10 mau makahiki | 3 × 8.75 ml | 3 × 4.5 ml | - | 3 × 7 ml |
| 30–40 | 10-12 mau makahiki | - | 3 × 6.5 ml | - | 3 × 9.5 ml |
| ≥40 | ʻ≥12 mau makahiki | Nā papa kekona Amoxiclav ® | |||
ʻO kēlā me kēia lā no ka hoʻokuʻuʻana i ka 400 mg + 57 mg / 5 ml
Hoʻomoe ʻia ka makeʻana i ka kg o ke kaumaha o ke kino, ma muli o ka nui o ka maʻi. Mai 25 mg / kg no ka maʻi o ka hōʻeha a i ke hoʻohaʻahaʻa i ka 45 mg / kg no nā maʻi ʻeha a me nā maʻi o ka hanu haʻahaʻa, otitis media, sinusitis (ma nā ʻōlelo o amoxicillin) i kēlā me kēia lā, i hoʻokaʻawale ʻia i 2 mau maʻi.
No ka hoʻomaʻamaʻa i nā dosa kūpono, ua kau ʻia kahi pēpē he 400 mg + 57 mg / 5 ml i kēlā me kēia paena o ka pona, ua hoʻokomo ʻia kahi pipette hoʻomākaʻi, puka puka pū i ka manawa 1, 2, 3, 4, 5 ml a me 4 mau wahi like.
Hoʻohana ʻia ka hoʻokuʻu ʻia o 400 mg + 57 mg / 5 ml i nā keiki i ʻoi aku o 3 mau mahina.
ʻO ke ʻano kūpono o ka pohō ʻana ma muli o ke kino o ke keiki a me ka nui o ka maʻi
| Kau ka paona | Nā ʻōpio (kahi kokoke) | Hana ʻia kā Damu, ml | |
| Kūʻai koʻikoʻi | Papa papa | ||
| 5–10 | 3-12 mahina | 2×2,5 | 2×1,25 |
| 10–15 | 1-2 mau makahiki | 2×3,75 | 2×2,5 |
| 15–20 | 2–4 makahiki | 2×5 | 2×3,75 |
| 20–30 | 4 makahiki - 6 mau makahiki | 2×7,5 | 2×5 |
| 30–40 | 6-10 mau makahiki | 2×10 | 2×6,5 |
Hoʻoholo ʻia nā dole kūpono i kēlā me kēia lā ma ke paona o ke keiki, a ʻaʻole ʻo kona makahiki.
ʻO ka nui loa o ka lā ma amoxicillin o 6 g no nā pākeke a 45 mg / kg no nā keiki.
ʻO ka nui loa o ka lā no clavulanic acid (ma ke ʻano o ka paʻakai pākela) ʻo 600 mg no nā pākeke a me 10 mg / kg no nā keiki.
I ka poʻe maʻi me ka hana renal impaired, pono ke hoʻoponopono ʻia e kau ʻia ma muli o ka nui o ka nui o ka dosis nui o ka amoxicillin.
ʻO nā mea maʻi me ka creatinine Cl> 30 ml / min, ʻaʻole ia e hoʻoponopono i kekahi lāʻau hoʻoponopono.
ʻO nā pākeke a me nā keiki ke kaupaona ʻana ma mua o 40 kg (ʻo ka nui o ka regimen e hōʻike ʻia nei no ka maʻi ʻana o ka papa e hōʻemi a me ka pilikia)
ʻO nā mea maʻi me ka Cl creatinine 10-30 ml / min - 500/125 mg 2 mau manawa i kahi lā.
I ka manawa iā Cl creatinine Cl creatinine 10-30 ml / min, ʻo ke kauoha i hōʻike ʻia he 15 / 3.75 mg / kg 2 mau manawa i ka lā (kiʻekiʻe 500/500 mg 2 mau manawa i ka lā).
Me Cl Clinine iv
Nā Keiki: me ke kaumaha o ke kino e emi iho ma lalo o 40 kg - ua kauʻia ke ʻano ma muli o ke kaumaha o ke kino.
ʻOi aku ma mua o 3 mau mahina me ke kaumaha o ke kino ma mua o 4 kg - 30 mg / kg (ma nā hua o ka lāʻau Amoxiclav ® a pau) i kēlā me kēia mau hola 12
Ma lalo o 3 mau mahina me ke kino o ke kino ma mua o 4 kg - 30 mg / kg (ma nā hua o ka lāʻau Amoxiclav ® a pau) i kēlā me kēia 8 mau hola
I nā keiki i ʻoi aku ma mua o 3 mau mahina, e lawelawe ʻia ʻo Amoxiclav ® i ka infusion lohi wale nō ma kahi o 30-40 mau minuke.
Na keiki mai 3 mau mahina a hiki i 12 mau makahiki - 30 mg / kg (ma nā ʻōlelo o ka mākaukau piha ʻo Amoxiclav ®) me kahi manawa o 8 mau hola, inā he maʻi koʻikoʻi - me kahi 6 o hola
ʻO nā keiki me ka hana pūlea pale ʻole
Kuhi ʻia ka hoʻoponopono ʻana i ka dosis ma ka nui o ke ʻano loiloi ʻo amoxicillin. No nā mea maʻi me Cl creatinine ma luna o 30 ml / min, ʻaʻole pono ka hoʻoponopono ʻana o ka maʻa.
Ke kaupaona nei nā keiki iā Cl creatinine 10-30 ml / min
ʻO nā pākeke a me nā keiki he 12 a keu paha ke kaupaona ʻana ma mua o 40 kg - 1,2 g o ka lāʻau lapaʻau (1000 + 200 mg) me kahi manawa o 8 mau hola, ma ke ʻano o kahi hopena koʻikoʻi - me kahi 6 o nā hola.
Nā kānana kūpono no ka pale ʻana o ka hōʻemi: 1.2 g me ka hoʻoluhi o ka anesthesia (me ka ʻoi ʻana o ka wā o ka hōʻemi ma mua o 2 mau hola). No nā hana lōʻihi - 1.2 g a 4 mau manawa i ka lā.
No nā mea maʻi me ka pūpū māmā, pono ke hoʻoponopono ʻia i ka nui o ka hopena a me / a i waena o nā inikua o ka lāʻau e pili ana i ke ʻano o ka lawa ʻole.
| Cl hana | Ka hana a / a waena paha o nā luna |
| > 0,5 ml / s (30 ml / min) | ʻAʻole koi ke hoʻoponopono ʻia |
| 0.166-00 ml / s (10-30 ml / min) | ʻO ka hapa mua loa he 1,2 g (1000 + 200 mg), a laila 600 mg (500 + 100 mg) iv i kēlā me kēia mau hola 12 |
| iv kēlā me 24 hola | |
| Anuria | Pono e hoʻonui ʻia ke koena kia 48 mau hola a keu paha. |
No ka mea, ua wehe ʻia ka 85% o ka lāʻau e ka hemodialysis, ma ka hope o kēlā me kēia kaʻina hemodialysis, pono ʻoe e komo i ka maʻi maʻamau o Amoxiclav ®. Me ka dialysis peritoneal, ʻaʻole pono ka hoʻoponopono ʻana.
ʻO ke ala e mālama ai i nā lā 5-14. Hoʻoholo ʻia ka lōʻihi o ke ʻano o ka mālama ʻana e ke kauka hele mai. Me ka hoʻohaʻahaʻa ʻana i ka uha o nā hōʻailona, ua neʻe ka hoʻololi i nā ʻano waha o Amoxiclav ® e hoʻomau i ka maʻi.
ʻO ka hoʻomākaukau ʻana i nā hoʻonā no ka maʻi injection. Hoʻomaloli i nā ʻike o ka ipu i ka wai no ka maʻi ʻana: 600 mg (500 + 100 mg) i 10 ml o ka wai no ka maʻi a i ʻole 1.2 g (1000 + 200 mg) i 20 ml o ka wai no ka maʻi. I loko / i mea e ulu mālie (i loko o 3-4 mau minuke).
E lawelawe ʻia ʻo Amoxiclav ® i loko o 20 mau minuke ma hope o ka hoʻomākaukau ʻana o nā mea hoʻonā no ka hoʻokele iv.
ʻO ka hoʻomākaukau ʻana i nā hoʻonā no ka infusion iv. No ka infusion o Amoxiclav ®, pono e hoʻopili hou ʻia: pono nā hoʻonā i hoʻomākaukau ʻia e loaʻa ana iā 600 mg (500 + 100 mg) a i 1,2 g (1000 + 200 mg) o ka lāʻau e hoʻemi ʻia i loko o 50 a 100 ml o ka hopena o ka infusion, ia. ʻO ka lōʻihi o ka infusion he 30-40 mau minuke.
Ke hoʻohana nei i nā waiila e hiki mai ana i loko o nā poloka i manaʻo ʻia i nā hoʻonā infusion, e mālama ʻia nā mea e pono ai ka antibiotic:
| Nā wai hou i hoʻohana | Pahu Hooko, h | |
| i 25 ° C | i 5 ° C | |
| Ka wai no ka ʻaina | 4 | 8 |
| ʻO 0.9% paʻakai sodium klorida no iv infusion | 4 | 8 |
| Hoʻolaha ka hopena o Ringer no ka lactate no ka iv infusion | 3 | |
| ʻO ka hopena o ka calcium chloride a me ka sodium klorida no iv infusion | 3 | |
ʻAʻole hiki ke hui pū ʻia ka hopena o ka lāʻau Amoxiclav ® me nā hopena o ka dextrose, dextran a i ʻole sodium bicarbonate.
E hoʻohana wale i nā mea hoʻonā maʻalahi. ʻAʻole ʻōlaʻa nā hoʻoponopono i hoʻomākaukau ʻia.
I loko. Hoʻonohonoho ʻia ka nui o ka dosage ma muli o ka makahiki, ke kino, ke ʻano, ka hana a ka mea maʻi a me ka nui o ka maʻi.
Pono e hoʻokaʻawale ʻia nā papa i ka hapalua o ke aniani o ka wai (ma kahi o 30 ml) a kāwili i ka maoli, a laila inu a paʻa paha i nā papa i loko o ka waha a pau a hoʻomalo wale ʻia, a laila puhi.
I mea e hōʻemi ai i ka hopena o nā hopena ʻaoʻao mai ka gastrointestinal tract, pono ke lawe ʻia ka lāʻau i ka hoʻomaka o ka ʻai.
Amoxiclav ® Nā Kūwila Kūʻai Kūʻai Kūʻai 500 mg / 125 mg:
ʻO nā pākeke a me nā keiki ma mua o 12 mau makahiki me ke kaumaha o ke kino ≥40 kg
No ka mālamaʻana i ka hopena o ka maʻi o ka palalelo i ke ʻano paʻakikī - 1 papa. (500 mg / 125 mg) i kēlā me kēia mau hola 12 (2 mau manawa i kahi lā).
No ka mālamaʻana i nā maʻi weliweli a me nā maʻi o ka ʻoihana hanu - 1 papa. (500 mg / 125 mg) kēlā me kēia mau hola 8 (3 mau manawa i ka lā).
ʻO ka palena loa o kēlā me kēia lā o Amoxiclav ® Quicktab he 1,500 mg o ka amoxicillin / 375 mg o ka clavulanic acid.
ʻO ka maʻi me ka hana renal impaired. I nā maʻi me ka creatinine Cl ma mua o 30 ml / min, ʻaʻole pono ka hoʻoponopono ʻana o ka maʻa.
ʻO nā ʻōpio a me nā keiki ʻoi aku ma mua o 12 mau makahiki me ke kaumaha o ke kino ≥40 kg (ʻo ka regimen hōʻailona i hōʻike ʻia no ka maʻi ʻana o ke ʻano maʻalahi a me ke kaumaha):
| Cl Mea hana, ml / min | Dosis |
| 10–30 | 500 mg / 125 mg 2 mau manawa i ka lā (me ka maʻi maʻalahi i ka maʻi koʻikoʻi) |
| ® Loaa 875 mg / 125 mg: |
ʻO nā pākeke a me nā keiki ma mua o 12 mau makahiki me ke kaumaha o ke kino ≥40 kg
I nā maʻi koʻikoʻi a me nā hopena i ka hanu - 1 papa. (875 mg / 125 mg) kēlā me kēia mau hola 12 (2 mau manawa i kahi lā).
ʻO ka lā helu o kēlā me kēia lā ka lāʻau ʻo Amoxiclav ® Quicktab i ka wā hoʻohana ʻia 2 mau manawa i ka lā he 1750 mg o ka amoxicillin / 250 mg o ka clavulanic acid.
ʻO ka maʻi me ka hana renal impaired. I nā mea maʻi me Cl creatinine ʻoi aku ka nui ma mua o 30 ml / min, ʻaʻohe mea pono o ka hoʻoponopono hoʻoponopono lāʻau.
No ka mea maʻi me Cl creatinine ma mua o 30 ml / min, ke hoʻohana ʻana i nā papa pālahalaha o ka lāʻau ʻAmoxiclav ® Quicktab, 875 mg / 125 mg, ua contraindicated.
Pono ka mea maʻi e lawe i ka lāʻau lapaʻau ma ke kaoa o 500 mg / 125 mg ma hope o ka hoʻoponopono ʻana o ka hoʻoponopono kūpono o ka creatinine Cl.
ʻO nā mea maʻi me ka hana pūlima hemahema. Ke lawe aku iā Amoxiclav ® Quicktab, pono e hoʻomaʻamaʻa. Pono ke nānā pono ʻana i nā hana ate. Ma ka hanana e hoʻomaka ʻia ka mālama ʻana me ka hoʻokele makua o ka lāʻau lapaʻau, hiki iā ia ke hoʻomau i ka maʻi me nā papa o Amoxiclav ® Quicktab.
Hoʻoholo ʻia ka lōʻihi o ke ala o ka mālama ʻia e ke kauka hele mai!
ʻO ka papa haʻahaʻa o nā mea maʻi maʻiʻo 5 mau lā. ʻAʻole pono e hoʻomau ka hoʻomehana no nā lā 14 me ka ʻole o ka loiloi o ke kūlana haukapila.
ʻLoe a me ke kākele
Lawe ʻia ka lāʻau lapaʻau. Hoʻoholo ka helu i kēlā me kēia lā e ke kauka, e hāʻawi i ka nui o ka maʻi a me ke kaumaha o ke kino o ka mea maʻi. No ka hoʻomākaukau ʻana i ka pīhoihoi i ka pauma, pono ʻoe e lūlū i ka ʻeke, ma nā ʻelua ʻelua e hoʻohui i ka nui o ka wai i hōʻike ʻia ma ka hōʻailona, hui pono. E hoʻopau piha ka paukē i loko o 10-15 kekona a loaʻa kahi wai mānoanoa. I mea e ʻike ai pehea e lawe ai iā Amoxiclav, pono ʻoe e familiarize iā ʻoe iho me ka papa ma lalo:
| Kau ka paona | Nā ʻōpio (kokoke | ʻO ka māmā a me ka maʻi maʻalahi | ʻO nā maʻi koʻikoʻi | ||
| 250 mg + 62.5 mg / 5 ml | 125 mg + 31.25 mg / 5 ml | 250 mg + 62.5 mg / 5 ml | 125 mg + 31.25 mg / 5 ml | ||
| 5-10 | mai 3 a 12 malama | 3x2.5 ml | 3x1.25 ml | 3x3.75 ml | 3x2 ml |
| 10-12 | mai 1 e 2 mau makahiki | 3x3.75 ml | 3x2 ml | 3x6.25 ml | 3x3 ml |
| 12-15 | mai 2 a i 4 makahiki | 3x5 ml | 3x2.5 ml | 3x3.75 ml | 3x2.75 ml |
| 15-20 | mai 4 a 6 mau makahiki | 3x6.25 ml | 3x3 ml | 3x9.5 ml | 3x5 ml |
| 20-30 | mai 6 a 10 mau makahiki | 3x8.75 ml | 3x4.5 ml | - | 3x7 ml |
| 30-40 | mai 10 a 12 makahiki | - | 3x6.5 ml | - | 3x9.5 ml |
| oi aku ma 40 | mai 12 mau makahiki | Kuhi ʻia ma ke ʻano o nā papa | |||
Pākuʻi helu
ʻO ka Powder no ka hoʻokuʻuʻana i ka waha, 156.25 mg / 5 ml a me 312.5 mg / 5 ml
5 ml a hoʻolei (1 ka pulu i ke kaha meʻoni pū) loaʻa
mea waiwai: 125 mg amoxicillin as amoxicillin trihydrate + 5% over over for stabil 6.25 mg, 31.25 mg clavulanic acid as potassium clavulanate (for dosage 156.25 mg / 5 ml) or 250 mg amoxicillin as amoxicillin trihydrate + 5% over for stabil stabil 12.5 mg, 62.5 mg clavulanic acid ma ke ʻano o ka pā clavulanate pākaʻi (no ke kaona o 312.5 mg / 5 ml).
nā mea hoʻohālikelike: ka waikawa citric anhydrous, aniumdrous sodium citrate, microcrystalline cellulose a me ka sodium carboxymethyl cellulose, xanthan gum, anhydrous colloidal silikonide, silicon dioxide, Strawberry flaving (no ka kuʻu ʻana o 156.25 mg / 5 ml), ʻono kai hoʻonaninani (no ka dosage o 312.5 mg / 5 ml), sima benzoate, sodium saccharin, maloʻo, mannitol.
ʻO ka paukū ma ke aniani mai ka keʻokeʻo a ʻulaʻula.
ʻO ka pēpē i hoʻomākaukau ʻia he pēpē homogeneous mai ka keʻokeʻo a keʻokeʻo i ka melemele.
ʻO nā waiwai Pharmacological
Lapaʻau lāʻau
ʻO Amoxicillin a me clavulanic acid i hoʻopau ʻia ma kahi hopena wai i pH o ke kino. Hoʻopili maikaʻi ʻia nā ʻaoʻao ʻelua ma hope o ka lawelawe waha. E kūpono e lawe i ka amoxicillin / clavulanic acid i ka wā a i ka hoʻomaka ʻana o kahi pāʻina. Ma hope o ka lawelawe waha, ka bioavailability o amoxicillin a me clavulanic acid ma kahi o 70%. ʻO ka poʻokela o ka launa o ka lāʻau i loko o ke kaila o nā mea ʻelua like like. Loaʻa ka ʻike Serum serum i ka hola 1 ma hope o ka hoʻokele ʻana.
Hoʻohālikelike ʻia nā ʻano ʻo amoxicillin a me ka waila clavulanic i loko o ka serum koko i ka wā e lawe ai i ka hui pū ʻana o nā mākau hoʻāla a amoxicillin / clavulanic e like nō me ka mea i ʻike ʻia me kahi lawelawe hoʻokaʻawaʻawa o ka waha o ka hui kūlike ʻo amoxicillin a me clavulanic acid.
Ma kahi o 25% o ka nui o ka huina clavulanic a me 18% o ka amoxicillin e hoʻopaʻa ai i nā protein plasma. ʻO ka nui o ka hoʻolaha no ka hoʻokolohua waha o ka lāʻau lapaʻau e pili ana i ka 0.3-0.4 l / kg o ka amoxicillin a me 0.2 l / kg o ka waikawa clavulanic.
Ma hope o ka hoʻonaninani intravenous, ua loaʻa nā amoxicillin a me clavulanic acid i loko o ka pālaʻi o ka ʻōpū, ka pona o ka ʻōpū o ka ʻōpū, ka ʻili, ka momona, ka ʻaoʻao o ka ʻōpū, ka synovial a me ka peritoneal wai, ka ʻōpū a me ka ihu. Amoxicillin i komo hewa i loko o ka wai o ka cerebrospinal.
ʻO Amoxicillin a me clavulanic acid e hoʻōla i ka paepae placental. Ua hoʻoili ʻia nā mea ʻelua i ka waiū umauma.
ʻO Amoxicillin i hoʻokaʻawale ʻia i loko o ka urine ma ke ʻano o ka waikawa penicillic acid i loko o nā huina o ka 10-25% o ka pākuʻi mua. Hoʻomomi ka huika Clavulanic i loko o ke kino a hoʻopiʻi ʻia i loko o ka pāʻai a me nā mea ʻai, a me ke ʻano o ka carbon dioxide me ka ea hanu.
ʻO ka hapalua hapalua hapalua o nā amoxicillin / clavulanic acid ka mea ma kahi o 1 hola, a ʻo ka nui awelika o ka welu he 25 l / h. Ma kahi o 60-70% o ka amoxicillin a me 40-65% o ka clavulanic acid e hoʻopiʻi ʻole i ka loli i ka urine i ka 6 mau hola mua ma hope o ka lawe ʻana i hoʻokahi lemona o nā papa waika amoxicillin / clavulanic. I loko o nā noiʻi like ʻole, ua loaʻa ka 50-85% o amoxicillin a me 27-60% o ka clavulanic acid e hoʻopio ʻia i loko o ka urine i loko o 24 mau hola. ʻO ka nui loa o ka waikawa clavulanic i hoʻopili ʻia i ka wā 2 mau hola ma hope o ka noi.
ʻO ka hoʻohana like ʻana o ka probenecid e hoʻolei ana i ka hoʻokuʻu o ka amoxicillin, akā ʻaʻole i pili kēia lāʻau i ka excretion o ka clavulanic acid ma o nā keiki.
ʻO ka hapalua o ka ola o ka amoxicillin e like me nā keiki i hala 3 mau makahiki a i 2 mau makahiki, i nā keiki a me nā pākeke. I ka hoʻonoho ʻana i ka lāʻau lapaʻau i nā keiki liʻiliʻi loa (me nā pēpē preterm) i nā hebedoma mua o ke ola, pono ʻole e lawelawe ʻia ka lāʻau lapaʻau ma mua o ʻelua mau manawa i ka lā, e pili pū ana me ka nui o ke ala o ka renal excretion ma nā keiki. Ma muli o ka ʻike pono ʻia o nā maʻi maʻi ʻōpala, pono ke kuhikuhi ʻia ka lāʻau lapaʻau me ka mālama pono ʻole i kēia pūʻulu o nā maʻi, akā inā pono, pono ke mālama ʻia ka hana o ka hana.
ʻO ka huina piha o ka amoxicillin / clavulanic acid i ka plasma e hoʻemi ana i ka kūlike pololei i ka hoʻemi ʻana o ka hana ʻoi. ʻOi ka hoʻohaʻahaʻa i ka hoʻopale amoxicillin e hōʻike hou ʻia i ka hoʻohālikelike clavulanic, no ka mea nui ka nui o ka amoxicillin e hoʻopili ʻia ma o nā keiki. No laila, i ke kuhikuhi ʻana i ka lāʻau lapaʻau i nā mea maʻi me ka pilikia ʻole, pono ke hoʻoponopono ʻia e pale ai i ka hōʻiliʻili nui ʻana o nā amoxicillin a mālama i ka pae pono o ka waila clavulanic.
Ke koho ʻana i ka lāʻau lapaʻau i nā mea maʻi me ka nele o ka puʻuwai, pono e hoʻomaʻamaʻa i ka wā e koho ana i kahi pākala a mālama pono i nā hana o ka ate.
Lapaʻau lāʻau
ʻO Amoxicillin kahi antibiotic semi-synthetic mai ka hui penicillin (beta-lactam antibiotic) e kāohi ana i hoʻokahi a keu aku paha ((i ʻōlelo pinepine ʻia e like me ka penicillin-nakinaki pū) ka mea i komo i ka biosynthesis o peptidoglycan, he mea nui ka hana hiʻona o ka paia o ka paʻu bacterial. Ke hōʻike nei i ka syntept peptidoglycan e alakaʻi i ka nāwaliwali o ka paia o ke kelepona, maʻamau ʻia e ka cell lysis a me ka make cell.
Ua luku ʻia ʻo Amoxicillin e ka beta-lactamases i kū ʻia e nā pōʻino kū kūpaʻa, a, no laila, ʻaʻole i komo ka sproxionil o nā hanaxicillin wale nō me ka hana ʻana i kēia mau enzymes.
ʻO Clavulanic waikawa he beta-lactam i hoʻopili pili me nā penicillins. Hoʻopili ia i kekahi mau beta-lactamases, ma laila e pale ai i ka hoʻopono ʻole o ka amoxicillin a hoʻonui i ka lawelawe o nā hana. Clavulanic acid ʻaʻole loa he hopena o ka maʻi antibacterial koʻikoʻi.
ʻO ka manawa ma luna o ka manawa liʻiliʻi o ka pipili liʻiliʻi liʻiliʻi (T> IPC) i manaʻo ʻia ʻo ka mea nui o ka hopena o ka hopena o ka hopenaxicillin.
ʻO nā papa hana kino ʻelua i kū kūʻē aku ai i ka amoxicillin a me nā waila clavulanic:
- ka hoʻihoʻi ʻole ʻana e nā beta-lactamases i nā mea ʻaʻole i paʻa i ka acid clavulanic, me nā papa B, C a me D.
- kahi hoʻololi i nā protein paʻa penicillin-hoʻoemi, e hōʻemi i ka pilina o ke aikena antibacterial i ka pathogen kiko.
ʻO ka hemahema o nā bakiʻi a i ʻole nā hana paha o ka pump efflux (ʻōnaehana ʻoihana) ke kumu a hoʻomau i ka pale ʻana i nā kūmole, ʻoi aku ka nui o ka bacteria-Negative.
Mea hana
Lek dd Verovshkova 57, Ljubljana, Slovenia.
No ka pauku no ka hoʻomākaukau o ka hoʻonā no ka hoʻokele intravenous hou
1. Lek dd, Verovshkova 57, Ljubljana, Slovenia.
2. Sandoz GmbH, Biohemistrasse 10 A-6250, Kundl, Austria.
Pono e hoʻouna ʻia nā koi o nā mea kūʻai aku i Sandoz CJSC: 125317, Moscow, Presnenskaya nab., 8, p.
Tel .: (495) 660-75-09, fax: (495) 660-75-10.
Amoxiclav ®
nā papa kiʻi ʻoniʻoni 250 mg + 125 mg 250 mg + 125 - 2 mau makahiki.
nā pani ʻoniʻoni kiʻi 500 mg + 125 mg 500 mg + 125 - 2 mau makahiki.
nā papa kiʻi ʻoniʻoni 875 mg + 125 mg 875 mg + 125 - 2 mau makahiki.
pauku no ka hoʻomākaukau ʻana i kahi hopena no ka hoʻokō intravenous o 500 mg + 100 mg 500 mg + 100 - 2 mau makahiki.
pauku no ka hoʻomākaukau ʻana i kahi hopena no ka hoʻokō intravenous o 1000 mg + 200 mg 1000 mg + 200 - 2 mau makahiki.
nā papa pālahalaha 500 mg + 125 mg 500 mg + 125 - 3 mau makahiki.
papa pālaʻi 875 mg + 125 mg 875 mg + 125 - 3 mau makahiki.
hoʻomoʻa no ka hoʻokuʻuʻana no ka hoʻokūkū waha 125 mg + 31.25 mg / 5 ml 125 mg + 31.25 mg / 5 - 2 mau makahiki. ʻO ka pau aʻe o ka hoʻopau ʻia he 7 lā.
pauku no ka hoʻōki ʻana no ka hoʻokūkū waha 250 mg + 62.5 mg / 5 ml 250 mg + 62.5 mg / 5 - 2 mau makahiki. ʻO ka pau aʻe o ka hoʻopau ʻia he 7 lā.
pauku no ka hoʻōki ʻana no ka hoʻokūkū waha 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 3 mau makahiki. ʻO ka pau aʻe o ka hoʻopau ʻia he 7 lā.
Mai hoʻohana ma hope o ka lā pau pau i hōʻike ʻia ma ka pahu.
Hoʻopili i nā lāʻau lapaʻau
Hoʻohana nui ʻia nā waha anticoagulants a me nā antibiotika o ka hui penicillin i loko o ka hoʻomaʻamaʻa ʻole me nā hōʻike lono. Eia naʻe, i loko o nā palapala i hoʻonui ʻia ka nui o ka ratio normalized ma nā poʻe maʻi e lawe ana i ka acenocoumarol a i ʻole warfarin me ka amoxicillin. Inā pono ka hoʻohana pinepine ʻana i nā lāʻau lapaʻau, pono ka manawa prothrombin a i ʻole ka laulima maʻamau maʻamau e nānā pono ʻia i ka wā i kuhikuhi ai a kāpae i ka amoxicillin. Eia kekahi, pono e loli i ke ʻano o ke anticoagulants waha.
Hiki i nā lāʻau penicillin-group ke hōʻemi i ka excretion o methotrexate, e hoʻonāukiuki i ka nui o nā pueo.
ʻAʻole hoʻohana ʻia ka hoʻohana pono ʻana o ka probenecid. Hoʻololi ʻo Probenecid i nā mea huna o ka maʻi huna o ka amoxicillin. Hoʻohana pinepine pū ʻia me Amoxiclav i ke koko o ke amoxicillin, akā ʻaʻole ka clavulanic acid.
ʻO ka hoʻohana pū ʻana o allopurinol a me Amoxiclav e hoʻonui i ka ulu o nā maʻi alerē. ʻAʻole ʻike nā ʻikepili i ka hoʻohana ʻana i ka allopurinol a me amoxiclav i kēia manawa.
I ka poʻe maʻi e lawe ana i ka mycophenolate mofetil, i hui pū ʻia me ka lāʻau lapaʻau Amoxiclav, ʻo ka hoʻomohala ʻana o ka metabolite ikaika o ka acid mycophenolic i ke kuhikuhi ʻana i ka lāʻau mua ma ka hoʻēmi ʻana ma kahi o 50%. ʻAʻole loli kahi loli ma ka pae o ka neʻe o ka hopena mua ma kahi loli i ke kahe o ka lehulehu o ka waila mycophenolic.
E hoʻokuʻu i ke ʻano a me ka pale
ʻO 25 g o ka pauka i kau ʻia i loko o ka pahu aniani i ʻokiʻoki i ka ʻōpū me ka nui o ka 125 ml, corked me nā pulima polistist twisting me ka mana o ka wehe mua.
ʻO ka pahu 1 me kahi pipette dosage a ua kauoha ʻia no ka hoʻohana olakino ma ka mokuʻāina a me nā ʻōlelo Lūkini e waiho ʻia ma loko o kahi kīʻaha pepa.
I ka wā hāpai
ʻAʻole i hoʻopilikia ʻia ka hana ʻo ka amoxicillin e kūlohelohe i ka maʻi fetus, no laila, inā he mākaʻina maopopo, kauka nā kauka i nā makuahine e hali ana. He mea nui hoʻi ia i ʻike ʻia e hoʻopili ʻia nā clavulanic acid a me ka amoxicillin i loko o liʻiliʻi me ka waiū. ʻAʻole hoʻonā kēia ʻōpū i kahi hoʻoweliweli, akā mālama ʻo nā kauka i ke kaʻina hana e hānai ai i ka nānā ʻole ʻana o ka ʻike ʻole ʻia o nā ʻano makemake ʻole o ke kino o ke keiki.
ʻO Amoxiclav no nā keiki
He mea maʻalahi ia i kahi ʻōpio'ōpiopio e komo i nā lāʻau i ka wai wai. Ma kēia kuleana, ua hoʻolālā ʻia ʻo Amoxiclav no nā keiki (a hiki i ka 12 makahiki) e ka poʻe pediatricians i ke ʻano o ka hoʻokuʻu ʻana homogeneous. Kuhi ʻia i ka inika, ʻaʻole ʻeha ʻo Amoxiclav i ka olakino olakino. ʻO ka ratio maʻamau o ka nui o ka lāʻau i ka paona kino he 40 mg / kg. ʻO ka dosage nui o kēlā me kēia lā he 45 mg / kg. No ka pale ʻana i nā hoʻopiʻi ʻana, ʻaʻole pono e hoʻonui ʻia. I loko o nā kumukūʻai nui loa, ko ka antibiotics Amoxiclav no nā keiki he pōʻino loa.
Kumukūʻai Amoxiclav
ʻO kahi mea nui no kēlā me kēia maʻi ka nui o ke kumukūʻai i kuhikuhi ʻia e ke kauka. ʻAʻole ʻōlelo nā kauka i ka mālama ʻana i ke olakino, eia naʻe, hiki iā ia ke kūʻai aku i ka lāʻau lapaʻau me nā hana like me nā antibakopa e like me ka hapa nui. Ke kūʻai nei i ka lāʻau lapaʻau me ka hopena like, e noʻonoʻo e kūkākūkā i ke kauka a hoʻopaʻa i nā ʻōkuhi no ka hoʻohana. I mea e hoʻomaopopo ai i ka nui o Amoxiclav a me nā kumukūʻai o kona mau kikowaena, e kōkua mai ka papa ma lalo:
| ʻO ka inoa o ka lāʻau lapaʻau | E hoʻokuʻu i nā palapala | Kūʻai (ma nā rubles) |
|---|---|---|
| Amoxiclav 2s | pauku | 96 |
| Amoxiclav | ʻO nā pōpō | 127 |
| Amoxicomb | pauku | 130 |
| Amoxil-K | pauku | 37 |
Alexandra, he 24 makahiki. I ka manawa i hana ʻia ai ke ʻano lāʻau lapaʻau maʻamau, ʻike nā kauka i ka cholecystitis. Hoʻolālā wale ʻia ʻo Amoxiclav. Heluhelu au i nā loiloi ma ka Pūnaewele, Ua hauʻoli wau. E hana maikaʻi, kūpono ke kumukūʻai. Ua paʻi ke kauka i kahi papa hoʻomākaukau o ka hoʻonā hoʻonā, i kuhikuhi ʻia nā pona o nā amoxicillin. Ua ʻōlelo ʻo ia he ikaika ke kino, ʻoi aku ka pākeke, no laila ʻaʻole hoʻopiʻi ka lāʻau. A pēlā ka mea. Ua hoʻi hou mai wau i kahi pule.
Victoria, 27 makahiki. Ua loaʻa ke kiʻi nui o nā kiʻi hoʻoilo i ka hoʻoilo ma ka ʻehaʻeha. Ua ʻōlelo ke kauka, ua hōʻemi wau i ka hana ate, no laila e pono e mālama nui ʻia. Ua koho ʻia ʻo Amoxiclav 1000 i ka puka pauka. I loko o hoʻokahi pule ua inu wau i 10 ml o ke kāpena a 3 mau manawa i ka lā a ua hala nā mea a pau. Mai nā antibiotika, hoʻomaʻamaʻa pinepine nā maʻi o koʻu puʻuwai, akā i kēia manawa ke uku. ʻIke ʻia ke ʻano o ke ʻano o ka pohō ʻana i koʻu kino.
ʻO Victor, 37 mau makahiki ʻo ʻAukake, ua hoʻokipa ʻia ke keiki me ka maʻi pneumonia. Ua kauoha ke kauka i ka maʻi ʻAmociclav antibiotic suspension 125. Ma muli o nā pilikia me ka coagulation koko, pono ke koi ʻia o anticoagulants. Ma ka loiloi e nā loiloi, ʻaʻole hoʻokipa ʻia kahi hui like ʻole, akā ʻaʻohe koho. Ke pale i nā hoʻopiʻi, ua hoʻemi ʻia ka nui o ka hoʻokuʻuʻana i ka 32 mg o amoxicillin no 1 kg o ka paona. Ua kūleʻa ka hoʻomaʻamaʻa.
ʻO Anna, 32 makahiki I hoʻokahi mahina i hala, ua maʻi kahi keiki. Lā ʻiwa, kahi ʻehaʻeha. Ua hōʻike ʻia ka haukapila me ka tonsillitis. ʻ saidlelo ke kauka e kōkua ʻo Amoxiclav suspension forte. Ua ʻike ʻo ia ka loli o ka nui o nā lāʻau i ka maʻi. Ua haʻi ʻo ia pehea e hoʻohana ai - lawe i 5 ml o ka amoxicillin 3 mau manawa i ka lā. E mālama i ka pīhoihoi i loko o ka friji. Ua hoʻōla hou lākou iā 3 i nā lā 3, ʻaʻohe mea pālolo.
