Mikardis® (40 mg) Telmisartan

ʻO nā lāʻau lapaʻa nā papa papa keʻokeʻo like me ka ukra 51H ma kekahi ʻaoʻao a me ka logo ʻoihana ma kēlā ʻaoʻao.

7 nā papa papa ʻia me kahi ala o 40 mg i loko o kahi palaha; 2 a 4 paha mau kīleʻe i loko o kahi pahu pepa. Nā kumulāʻau e 7 paha me kahi ala he 80 mg ma ke kue, 2, 4 a i ʻole 8 mau blisters i loko o kahi pahu pahu

Pharmacodynamics a me ka pharmacokinetics

Lapaʻau lāʻau

Telmisartan - nā mea koho pani koho angiotensin II. ^ E Ha yM. He tropism kiʻekiʻe ma AT1 kūloko subtype angiotensin II. ^ E Ha yM. Nā hoʻokūkū me angiotensin II i nā mea kikoʻī kūikawā me ka ʻole o ka hopena like. ʻO ka hoʻomau ka hoʻomau.

ʻAʻole ia e hōʻike i kahi tropism no nā subtypes o nā receptors. Hoʻemi i ka ʻike aldosterone i loko o ke koko, ʻaʻole e kaohi i ka plasma renin a me nā kaila ion i loko o nā hale.

Hoʻomaka hopena hypotensive nānā ʻia i loko o nā hola ʻekolu i hala ma hope o ka hoʻokele ʻana telmisartan. ^ E Ha yM. Hana wale ka hana no kahi lā a i ʻole. Hoʻoulu ka hopena ʻōlelo i ka mahina ma hope o ka hoʻokele mau ʻana.

I nā poʻe me haehae maʻitelmisartan hōʻemi i ka systolic a me ke kaomi diastolic, akā ʻaʻole ia e hoʻololi i ka nui o ka pūhaka puʻuwai.

ʻAʻole ia e hoʻokau i ka maʻi hoihoi.

Lapaʻau lāʻau

Ke lawe wale ʻia, lawe koke ʻo ia mai nā ʻōpū. ʻO ka bioavailability e kokoke ana i ka 50%. Ma hope o ʻekolu mau hola, lilo ka lōʻihi o ke kaila plasma. 99.5% o ka mea hana ikaika e hoʻopili ai i nā ʻōnaehana koko. Metabolized by pane me waikawa glucuronic. ^ E Ha yM. ʻAʻole ikaika ka metabolites o ka lāʻau. ʻO ka hoʻopau hapa hapa-ola e ʻoi aku ma mua o 20 mau hola. Hoʻokuʻu ʻia ia ma o ka hoʻowalewale ʻana, ʻo ka excretion i loko o ka urine ma lalo o 2%.

Nā Hoʻohui

Nā contardicated nā papa Micardis i kēlā me kēia me nā pepeke ma luna o nā māhele o ka lāʻau lapaʻau, kaumaha nui maʻinā ate a i ʻoleʻōpala,kuʻi ʻole ʻauʻai, i ka wā hāpai a lactation, mau keiki malalo o na makahiki 18 paha.

Nā hopena hopena

• Mai ka pūnaehana neʻe o waena: manaʻo ʻinoāhāhuʻe lie kanikelaluhi, hopohopo, ʻōpala, nahoa.
• Mai ka papa hana hanu: nā maʻi o ka ʻalihi hanu kiʻekiʻe (sinusitis, pharyngitis, ʻOluomini), kauā.
• Mai ka pūnaehana neʻe: haʻi ʻia ʻana i ka emi o ka ikaika, tachycardia, brieociaiaʻeha ka naʻau.
• Mai ka pūnaehana hana ʻana: mualea, nā ninia, ʻumiinake hoʻonui nei i nā kao o nā ʻoli ate.
• Mai ka ʻōnaehana musculoskeletal: myalgiaʻeha ʻeha hope aolaila.
• Mai ka pūnaehana genitourinary: edema, nā maʻi o ka ʻōnaehana genitourinary, luhi.
• Hypersensitivity Mea Hoʻoikaika: Skin Rash, angioedema, urticaria.
• Nā hōʻailona hana Laboratory: anemia, hyperkalemia.
• Nā ʻili: erythemahuu dyspnea.

Mikardis, nā ʻōlelo aʻoaʻo no ka hoʻohana

Wahi a nā ʻōlelo kuhikuhi no ka hoʻohana ʻana o Mikardis, lawe ʻia ka lāʻau lapaʻau. Hoʻolako ʻia no nā pākeke dosis 40 mg i ka maka? i. I kekahi mau o nā mea maʻi, ua nānā ʻia ka hopena therapeutic i ka wā e lawe ana i ka pākōʻai20 mg i ka la. Inā ʻaʻole mālama ʻia kahi emi ʻana o ke kaomi i ka pae i makemake ʻia, a laila hiki ke hoʻonui ʻia ka nui i ka 80 mg i kēlā me kēia lā.

Loaʻa ka hopena kiʻekiʻe o ka lāʻau i ʻelima mau pule ma hope o ka hoʻomaka ʻana o ka lāʻau.

I ka poʻe maʻi me nā maʻi koʻikoʻi haehae maʻi hiki ke hoʻohana 160 mglālapa i kēlā lā.

Hoʻohui

Telmisartan hoʻōla hopena hypotensive ʻano ʻē aʻe o ka hoʻohaʻahaʻa ʻana.

Ke hoʻohana pū ʻia telmisartan a kāmakua pono pika noonoo no ka lohi kāmakua i ke koko, e hiki ke ala.

Ke lawe pū pū ʻia nā lāʻau lithium a ACE paleai ʻike ʻia kahi manawa liʻiliʻi o nā ʻike lithiumi loko o ke koko, i hōʻike ʻia e nā hopena ʻona.

Hoʻomaʻamaʻa ole-lāʻau lapaau anti-inflammatory a me Mikardis ma nā maʻi dehydrated hiki ke alakaʻi i ka hoʻomohala ʻana o ka hiki ʻole o ka hana renal.

Nā ʻōlelo kikoʻī

No ka maʻi nā maʻi (ka palena paʻakai, mālama hoʻoiho, nā ninia, ka luaʻi) kahi mea i pono ai ʻo Mikardis he mea pono.

Me ka mālama aka, koho i nā kānaka me stenosiso laua nā hāmeʻa maʻi, méni valve stenosisa i ʻole aortic hypertrophic cardiomyopathy obstrive, renal koʻikoʻi, hepatic a i ʻole ʻole ka naʻau, nā maʻi o ka ʻalā.

Pāpā ʻia ka hoʻohana ʻana i ka wā aldosteronism maʻamaua kuʻi ʻole ʻauʻai.

Me kahi hoʻohala hoʻolālā, pono ʻoe e loaʻa mua i kahi mea ku pono no Mikardis me kekahi ka lāʻau antihypertensive.

E hoʻohana me ka akahele inā ka holo kaʻa.

Me ka hoʻohana me ka lāʻau lapaʻau lithium hōʻike ʻia nā nānā 'ana o ka lithium ma ke koko, no ka mea, he hiki ke hoʻonui iki.

Pākuʻi helu

Nā Papa 40 mg, 80 mg

Aia ma ka papa papa

mea waiwai - telmisartan 40 a 80 mg, kēlā

nā mea hoʻowalewale: sodium hydroxide, povidone K 25, meglumine, sorbitol P6, magnesium stearate.

40 mg papa - nā papa pāpaʻi hālima, keʻokeʻo a ʻāhinahina paha ke keʻokeʻo, me ka hōʻailona ʻana o ka 51N ma ka ʻaoʻao a me ka logo ʻoihana ma nā ʻaoʻao, me kahi pā biconvex, kahi mānoanoa 3.6 - 4.2 mm.

80 papa papa - nā papa pāpaʻi hālima, keʻokeʻo a ʻokoʻa paha ke keʻokeʻo, me ka 52N māka ma kekahi ʻaoʻao a me ka hōʻailona ʻoihana ma nā ʻaoʻao, me kahi pā biconvex, 4.4 - 5.0 mm mānoanoa.

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau

Hoʻopili koke ʻia ʻo Telmisartan, ʻokoʻa ka nui o ka mea i hoʻopili ʻia. ʻO ka bioavailability o ka telmisartan ma kahi o 50%.

Ke lawe nei i ka telmisartan me ka meaʻai, ka nui o ka kaila o AUC (ma lalo o ka pihi ʻana i ka manawa o ka paʻa) ma waena o 6% (ma kahi iki o 40 mg) ka 19% (ma kahi kikoʻī o 160 mg). 3 mau hola ma hope o ke kauā ʻana, ka ʻike ʻana i ke kahe o ka plasma koko i waho, me kahi ʻaʻai ʻole. ʻO kahi emi iki ma AUC, ʻaʻole ia eʻae i kahi hōʻemi i kahi hopena therapeutic.

Aia kekahi ʻokoʻa ma ka nānā ʻana o ka plasma i loko o nā kāne a me nā wahine. ʻO Cmax (ʻoi loa ka ʻike) a me AUC paha ma kahi o 3 a 2 mau manawa ke kiʻekiʻe o nā wahine i hoʻohālikelike ʻia me nā kāne me ka loaʻa ʻole o kahi hopena koʻikoʻi.

ʻO ke kamaʻilio me nā protein plasma iʻoi aku ma mua o 99.5%, ʻo ka mea nui me ka albumin a me alpha-1 glycoprotein. ʻO ka nui o ka puʻuwai e like me 500 lita.

Hoʻopili ʻia ka Telmisartan e ka hoʻopili ʻana i ka mea hoʻomaka me ka glucuronide. ʻAʻole i loaʻa kahi hana lapaʻau me kahi o ka conjugate.

He ʻano biexponential ʻo Telmisartan o ka pharmacokinetics me kahi hoʻopau hoʻopau hapa hapa-ola> 20 mau hola. Cmax a - i kahi kikoʻī liʻiliʻi - hoʻonui ʻia ʻo AUC disproportionately me ka ʻōpū. ʻAʻole i ʻike ʻia kekahi kumulāʻau koʻikoʻi o ke telmisartan.

Ma hope o ka lawelawe waha, ua pau nā telmisartan ma loko o ka ʻōpū o ka ʻōpū. Ka huina o ka urinary excretion ma mua o 2% o ka nui o ka huapalapala. Kūpono ka huina piha piha plasma (ma kahi o 900 ml / min) i hoʻohālikelike ʻia me ke kahe koko hepatic (ma kahi o 1500 ml / min).

ʻO nā maʻi maʻi

ʻAʻole loli nā pharmacokinetics o ke telmisartan i nā maʻi maʻi maʻi.

ʻO nā mea maʻi me ka maikaʻi ʻole o ka pūpū

I ka poʻe maʻi me ka renal ka hoʻomaʻemaʻe ʻana i ka hemodialysis, ʻike ʻia nā kaila plasma ma lalo. I ka poʻe maʻi me ka pilikia ʻole, pili ka telmisartan i ka protein plasma a ʻaʻole i hoʻopā ʻia i ka wā o ka dialysis. Me ka nele o ka renal, ʻaʻole i loli ka hapalua.

ʻO nā maʻi me ka palaualohi maʻa

I ka poʻe maʻi me ka maʻi hepatic, ʻo ka bioavailability piha loa o ka telmisartan e hoʻonui i ka 100%. ʻO ka hapalua hapalua no ke akeʻai ʻaʻole loli.

ʻO ka pharmacokinetics o nā inikua o ka telmisartan i loiloi i nā mea maʻi me ka maʻi hypertension (n = 57) ʻo 6 a 18 makahiki mau makahiki ma hope o ka lawe ʻana i ka telmisartan ma nā kūmole o ka 1 mg / kg a i ka 2 mg / kg no ka manawa mālama heʻehā pule. Ua hōʻoia ko nā hopena o ka noi ʻana ua paʻa ka pharmacokinetics o telmisartan i nā keiki ma lalo o nā makahiki he 12 i ka poʻe me ka pākeke a, i ka mea maʻamau ua hōʻoia ʻia ka ʻano non-linear o Cmax.

Lapaʻau lāʻau

ʻO MIKARDIS kahi hana kūpono a me ka kikoʻī (selektif) angiotensin II receptor antagonist (type AT1) no ka hoʻoponopono waha. Ke pio nei ʻo Telmisartan me ka puʻuwai kiʻekiʻe i ka angiotensin II mai kāna mau wahi hoʻopaʻa ʻia i nā mea hoʻokipa sublipe AT1, nona ka hopena i ʻike ʻia o ka angiotensin II. ʻAʻohe Telmisartan i kahi hopena agonist i ka mea hoʻokipa AT1. Hoʻopili paʻa a Telmisartan i nā ʻĀpana AT1. Ke hoʻomau nei ka pilina. ʻAʻole i hōʻike ʻo Telmisartan i ka pilina no nā mea hoʻohana ʻē aʻe, e komo pū ana me ka ʻĀpana AT2 a me nā mea ʻē aʻe, i haʻahaʻa ʻia nā mea i ʻae ʻia ʻo AT.

Ka hana koʻikoʻi o kēia mau mea nānā, a me ka hopena o ko lākou hiki ke hoʻoulu ʻia me ka angiotensin II, ke ʻano o ka piʻi ʻana me ke koho ʻana i ka telmisartan, ʻaʻole i aʻo ʻia ʻia.

Hoʻopau ʻo Telmisartan i nā pae aldosterone plasma, ʻaʻole pale i ka renin i ka plasma o ke kanaka a me nā kaila ion.

ʻAʻole i hoʻoneʻe ke Telmisartan i ka angiotensin-hoʻohuli i ka enzyme (kinase II), e hoʻopau ai i ka bradykinin. No laila, ʻaʻohe mea hoʻoikaika o nā hopena ʻili e pili ana i ka hana a bradykinin.

I loko o nā kānaka, he hapa o 80 mg o telmisartan aneane e pale iki i ka hoʻonui ʻana i ke kahe o ke koko (BP) i manaʻo ʻia e ka angiotensin II. Mālama ʻia ka hopena pale ma mua o 24 mau hola a hoʻopaʻa ʻia nō hoʻi ma hope o 48 mau hola.

Ka hoʻomaʻamaʻa ʻana o nā hypertension arterial pono

Ma hope o ka lawe ʻana i ka hapa mua o ka telmisartan, hoʻemi ʻia ke koko ma hope o 3 mau hola. ʻO ka manawa kiʻekiʻe o ke koʻi koko e hōʻemi pono nei i nā hebedoma 4 ma hope o ka hoʻomaka ʻana o ka mālama ʻana a mālama ʻia no ka manawa lōʻihi.

Ua mau ka hopena antihypertensive no 24 mau hola ma hope o ka lawe ʻana i ka lāʻau, me ka 4 mau hola ma mua o ka lawe ʻana i ka hopena hou, e hōʻoia ʻia ana e nā maʻi ana o ka maʻi outpatient, a me ka paʻa (ma luna o 80%) nā kuʻina o ka liʻiliʻi a me ka piʻi ʻana o ka lāʻau lapaʻau ma hope o ka lawe ʻana i ka 40 a me 80 mg o MIKARDIS i nā hoʻokolohua lapaʻau i hoʻopaʻa ʻia. . ^ E Ha yM.

I ka poʻe maʻi me ka hypertension, ʻo ka MIKARDIS e hōʻemi i nā kaila o ke systolic a me ka diastolic me ke ʻano o ka loli ʻana o ka puʻuwai puʻuwai.

Ua hoʻohālikelike ʻia ka hopena antihypertensive o ka telmisartan me nā ʻelele o nā papa ʻē aʻe o nā lāʻau antihypertensive, e like me: amlodipine, atenolol, enalapril, hydrochlorothiazide, losartan, lisinopril, ramipril a me valsartan.

I ka hihia o ka hōneʻe ʻana o MIKARDIS, e hoʻi ka neʻe i ke koko i nā waiwai ma mua o ka mālama ʻana no kekahi mau lā me ka ʻole o nā hōʻailona o ka hoʻomau hou ʻana o ka maʻi (a laila ʻaʻohe "rebound" syndrome).

Ua hōʻike ʻia nā haʻawina haukaʻi e pili ana ka telmisartan me kahi hoʻoliʻelika nui a me ka nui o ka lehulehu o ka ventricular mass a waiho i ka index ventricular mass i ka poʻe maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular.

ʻO nā mea maʻi me ka maʻi hypertension a me ka nephropathy maʻi i mālama ʻia me MIKARDIS e hōʻike i kahi kaila nui i ka statistically nui (me ka microalbuminuria a me ka macroalbuminuria).

I nā hoʻokolohua lapaʻau ākea multicenter, ua hōʻike ʻia aia nā mea liʻiliʻi o nā maʻi maloʻo ma ka poʻe maʻi e lawe nei i ka telmisartan ma mua o nā mea maʻi e loaʻa ana i ka angiotensin-hoʻololi ʻana i ka hana o ka enzyme (ACE inhibitors).

Kāohi i ka morbidity cardiovascular a me ka make

I nā maʻi maʻi 55 mau makahiki a ʻoi aku ka moʻaukala o ka naʻau puʻukui coronary, stroke, peripheral vascular disease a me ka maʻi mellitus me ka maʻi ʻona o nā hanana (retinopathy, hypertrophy ventricular, macro a me microalbuminuria), ka hoʻohana ʻana o MIKARDIS hiki ke hōʻemi i ka hiki ʻana o myocardial infarction, stroke puʻuwai naʻau a hōʻemi i ka make ma mua o nā maʻi cardiovascular.

ʻO ka hopena antihypertensive o ka telmisartan i loiloi i nā mea maʻi me ka maʻi maʻi hypertension i ka makahiki 6 a 18 makahiki (n = 76) ma hope o ka lawe ʻana i ka telmisartan ma kahi maʻi o 1 mg / kg (mālama ʻia n = 30) a i ʻole 2 mg / kg (mālama ʻia n = 31) no ka mālamaʻana i hoʻokahi mau hebedoma. . ^ E Ha yM.

ʻO ke kahe koko nui o ka Systolic (SBP) ma ka awelika ua hōʻemi ʻia mai ka waiwai mua e 8,5 mm Hg a me 3.6 mm Hg. i nā hui telmisartan, 2 mg / kg a me 1 mg / kg, ma muli. ʻO ke kaila koko diastolic (DBP) i ka awelika i hōʻemi ʻia mai ka waiwai mua e ka 4.5 mmHg. a he 4.8 mmHg i nā hui telmisartan, 1 mg / kg a me 2 mg / kg, kēlā.

Kau ʻia nā loli i hilinaʻi ʻia.

Ua hoʻohālikelike ka ka palekana palekana ma ia nā mea maʻi.

ʻLoe a me ke kākele

Ka hoʻomaʻamaʻa ʻana o nā hypertension arterial pono

ʻO ka dosis ʻōpiopio i ʻōlelo ʻia e 40 mg hoʻokahi i kēlā me kēia lā.

I nā hihia i loaʻa ʻole ai ke koko i makemake ʻia, hiki ke hoʻonui ʻia i loko o MIKARDIS ka nui o 80 mg hoʻokahi i ka lā.

Ke hoʻonui nei i ka pona, pono e noʻonoʻo ia i ka hopena antihypertensive ka hopena e hana pinepine ʻia ma loko o ʻehā a ʻewalu mau pule ma hope o ka hoʻomaka ʻana o ka mālama ʻana.

Hiki ke hoʻohana ʻia ke Telmisartan me ka hoʻohui me ka diuret thiazide, no ka laʻana, hydrochlorothiazide, i hui pū ʻia me ka telmisartan i kahi hopena hypotensive hou.

I ka poʻe maʻi me ka maʻi hypertension arterial, ʻo ka nui o ka telmisartan he 160 mg / lā (ʻelua mau kīpika o MIKARDIS 80 mg) a hui pū me ka hydrochlorothiazide 12.5-25 mg / lā i hoʻohaʻomaʻi maikaʻi ʻia a hoʻohana ʻia ia.

Kāohi i ka morbidity cardiovascular a me ka make

ʻO ka dosis i ʻōlelo ʻia e 80 mg hoʻokahi i kēlā me kēia lā.

ʻAʻole i hoʻoholo ʻia inā he mau haʻahaʻa ma lalo o ka 80 mg i mea e hōʻemi ai i ka morbidity cardiovascular a me ka make.

I ka hoʻomaka mua o ka hoʻohana ʻana o telmisartan no ka pale ʻana o ka morbidity cardiovascular a me ka make kino, e pono ai e mālama i ke kaʻe o ke koko (BP), a ʻo nā mea hoʻoponopono ʻoi ʻana paha e pono ai me nā lāʻau lapaʻau e hoʻohaʻahaʻa i ke koko.

Hiki ke lawe ʻia ka MIKARDIS me ka manaʻo o ka ʻona o ka meaʻai.

ʻAʻole koi ʻia nā loli i nā maʻi me nā pilikia ʻole, a me nā mea maʻi ma ka hemodialysis. ʻAʻole lawe ʻia ke Telmisartan mai ke koko i ka wā o ka hemofiltration.

I ka poʻe maʻi me ka pīhoihoi haʻalulu maʻalahi ke ʻano, ʻaʻole pono ka nui o ka lāʻau i kēlā me kēia lā he 40 mg hoʻokahi i ka lā.

ʻAʻole pono ke hoʻoponopono ʻia.

ʻAʻole paʻa ma ka palekana a me ka hana o ka MIKARDIS ma nā keiki ma lalo o 18 makahiki o kona mau makahiki.

Ka hoʻokūkū a me ka hana lāʻau lapaʻau a Mikardis

ʻO ke kumu nui o ka lāʻau ka Telmisartan. I loko o kahi papa hoʻokahi hiki iā ia ke loaʻa 80, 40 a 20 mg paha. ʻO nā mea hoihoi o ka lāʻau lapaʻau e hoʻomaikaʻi i ka hoʻopihapiha ʻana o ka mea nui ma ka meglumine, sodium hydroxide, polyvidone, sorbitol, magnesium stearate.

ʻO Mikardis kahi antagonist receptor-2 hormone hʻano. ^ E Ha yM. Hoʻonui kēia hormon i ke kani o nā paia vascular, e alakaʻi ana i kahi o ka lumen o nā moku. ʻO Telmisartan i kāna hana kemana e like me kahi subspecies o nā ʻalemeponoʻonopela AT1.

Ma hope o ke komo ʻana i ke kino, haku ʻia ʻo Mikardis i nā mea paʻa me ka ʻĀina AT1 a ke alakaʻi nei kēia i ka neʻe o ka angiotensin, ʻo ia ke kumu o ka piʻi ʻana o ka pehu o ke koko. Ke alakaʻi nei ʻo Telmisartan i kahi hoʻohaʻahaʻa i ka systolic a me ka diastolic pressure, akā ʻaʻole kēia mea hoʻololi i ka ikaika a me ka helu o nā aelike ʻana o ka puʻuwai puʻuwai.

E alakaʻi ka hoʻohana mua o Mikardis i kahi kaohi mau ʻana i ke kao o ke koko - e neʻe malie ana ia ma mua o ʻekolu mau hola.Hoʻomaopopo ka hopena antihypertensive ma hope o ka lawe ʻana i nā papa no ka liʻiliʻi o hoʻokahi lā, ʻo ia hoʻi, i mea e mālama pono ai i ka pume ma ke ʻano, he pono e inu i ka lāʻau lapaʻau i hoʻokahi wale nō i ka lā.

ʻO ka palena nui a hoʻomau mau i ka neʻe ʻana ma hope o ʻehā a ʻelima paha mau pule mai ka hoʻomaka ʻana o ka mālama ʻana me Mikardis. I ka hopena e hoʻopau koke ʻia ka lāʻau lapaʻau, ʻaʻole i loli ka hopena hoʻoneʻe, ʻo ia hoʻi, ʻaʻole hoʻi ke ʻano o ke koko i kona mau kuhikuhi kumu hoʻohiki, maʻamau ʻo ia ka mea i loko o kekahi mau pule.

ʻO nā mea āpau o Mikardis, ke lawe waha ʻia mai ka ʻōpū mai, e komo koke ana, ʻo ka bioavailability o ka lāʻau pili i 50%. Hoʻoholo ka ʻike ʻoi loa o ka waiwai ikaika i ka plasma ma hope o 3 mau hola.

Hoʻomaka ka metabolization ma ke ʻano o ka telmisartan me ka hoʻohuihui glucoseuronic, ʻaʻole i kūlike ka metabolite hopena. ʻO ka hoʻopau hapa-ola e hana hou aku ma mua o 20 mau hola. Hoʻopau ʻia ka lāʻau lapaʻau me ka feces, ʻoi aku ka liʻiliʻi ma 2% o ka lāʻau i hoʻokuʻu ʻia me ka urine.

I ka manawa e hoʻohana ai

Hoʻolālā ʻia ka lāʻau lapaʻau ʻo Mikardis e mālama i ka maʻi hypertension. Ua kuhikuhi kekahi mau kauka i nā lāʻau lapaʻau no nā poʻe maʻi ma mua o 55 mau makahiki he nui ka piʻi ʻana o ka hoʻomohala ʻana i nā maʻi cardiological koʻikoʻi e pili ana i ka hypertension arterial.

Ma kahi o Mikardis maʻamau, loaʻa iā Mikardis Plus. ʻO kēia lāʻau lapaʻau, ʻo ka hoʻohui ʻana i ka telmisartan, he 12,5 mg hou o ka hydrochlorothiazide, he mea diuretic kēia mea.

ʻO ka hui pū ʻana o ka diuretic a me kahi aniotiotinin e hiki ai iā ʻoe ke hoʻokō i ka hopena hypotensive nui o ka lāʻau.. ^ E Ha yM. Hoʻopilikia kekahi hopena diuretic ma kahi o ʻelua mau hola ma hope o ka lawe i ka paila. ʻO ka ʻōlelo no ka mycardis plus e hōʻike ʻia ana kēia lāʻau lapaʻau inā ʻaʻole hiki ke hoʻokō ʻia ka hopena hoʻoneʻe i makemake ʻia i ka wā e lawe ai i ke ʻano maʻamau o ka lāʻau antihypertensive.

Aia ʻo contardicated ʻo Mikardis

Loaʻa iā Mikardis 40 nā like like like me nā papa me nā ʻano like ʻokoʻa. ʻAʻole i lawe ʻia ka lāʻau me kēia lāʻau antihypertensive:

• Inā hoʻokomo ka hypersensitivity i nā ʻāpana nui a i ʻole nā ​​ʻāpana hou o ka lāʻau.
• ʻO nā mea āpau o ka hāpai a i ka wā o ka ʻānai ʻana,
• Inā loaʻa i ka mea maʻi ke ala o ka pathary tractology e hoʻopilikia ai i ko lākou lolo,
• Me nā kuhi koʻikoʻi i ka hana o ke akea a me nā pōpoki.
• Me ka intolerance fructose hoʻoilina.

Pono e ʻimi ʻia nā alakii Mikardis i ka mālama ʻia ʻana o ka maʻi hypertension i ka poʻe ʻōpio a me nā keiki, kēia ma muli o ka ʻike ʻole o ka hopena o ka telmisartan i kahi hanana ʻano piha ʻole i hoʻokumu ʻia.

ʻO ka ʻōlelo no ka mycardis plus e hōʻike aku, i ka hoʻohui i nā contraindications i luna, ʻaʻole pono ke kuhikuhi pono i ka lāʻau i nā mea maʻi me ka hypercalcemia refractory a me hypokalemia, me ka hapa o ka lactase a me ka pale ʻole o ka lactose a me ka galactose.

Aia nā pilina contraindications i ka lāʻau mycardis. ʻO ia ka mea, pono e mālama ke kauka a hoʻomaka i ka mālama ʻana me kahi hōʻemi haʻahaʻa, inā he mōʻaukala o ka hypertension:

• Hyponatremia a i ʻole hyperkalemia,
• CHD - ischemia o ka puʻuwai,
• ʻO nā maʻi o ka puʻuwai - nā maʻi kūpaʻa, ka stenosis valve, cardiomyopathy,
• ʻO ka ʻeha o nā lāʻau ʻelua o nā keiki - inā he mea hoʻokahi wale nō ka mea maʻi, e makaʻala ʻia i ka wā e kuhikuhi ana i ka lāʻau lapaʻau inā he stenosis o ke kīʻaha a ke koko wale nō,
• ʻO ka huehue ma muli o ka hoʻopuʻi a me ka maʻi ʻaʻī,
• ʻO ka hoʻomaʻamaʻa ʻana me ka diuretics,
• Hoʻoulu ma hope o ka hoʻololi ʻana i kahi kidney.

Loaʻa nā hopena maikaʻi loa

ʻAʻole maikaʻi nā loiloi Mycardis i kēlā me kēia. Hoʻomaopopo kekahi mau mea maʻi i ke ʻano o nā loli ʻē aʻe o ka maikaʻi o ke olakino maikaʻi, a ʻo ko lākou hoʻomohala pololei i hilinaʻi ʻia ma ka ʻano o ka lāʻau lapaʻau, ma ke ʻano o ka mea maʻi a me ka hele ʻana o nā pathology concomitant. I ka hapanui pinepine, hiki i nā loli aʻe:

• ʻO ka manawa lahilahi, ka ʻeha, ka luhi a me ka hopohopo, ke kaumaha, ka insomnia, ma nā hihia loaʻa, nā mea hoʻoweliweli.
• Hoʻonui i ka hikiwawe o ka ʻōpū o ka ʻōpū o nā maʻi i ka huelo, e hoʻohuli ai i ka pharyngitis, sinusitis, bronchitis a me ka pā paroxysmal.
• ʻO nā maʻi dyspeptic i ke ʻano o ka maʻi pāpaʻi, ka ʻōpū o ka ʻōpū, a me nā huehue. I kekahi mau mea maʻi, hōʻike nā hōʻike i kahi hoʻonui o nā enzyme o ka lolo.
• ʻO ka maʻi hypotension, ʻeha ʻeha, tachycardia, a i ʻole ka hoʻohālikelike bradycardia.
• ʻO ka ʻeha o ka ʻōpū, arthralgia, ʻeha i ka lumbar spine spine.
• ʻO ka hoʻopōʻinoʻino ʻana i ka hōpili genitourinary, ke noho paʻa nei i loko o ke kino.
• ʻO nā kūmole o ke kūloko i ke ʻano o ka rashes o ke kino, urticaria, angioedema, itching, erythema.
• Ma nā hoʻokolohua hōʻoia - hyperkalemia a me nā hōʻailona o ka anemia.

Ua hoʻokumu ʻia nā noi preclinical o Mikardis i ka hopena fetotoxic o ka lāʻau. Ma kēia mea, pono ʻole e hoʻohana i kēia lāʻau lapaʻau i ka wā hāpai.

Inā hoʻoholoʻia ka ʻanepili, a laila, pono ka mea maʻi, ma ke kauoha a ke kauka, e huli i nā lāʻau antihypertensive e palekana loa. Ma ka hanana ʻo ka hāpai ʻana ma ke ala o ka mālama ʻana me Mikardis, ua hoʻopau koke ka hana o kēia lāʻau.

Nā hiʻohiʻona noi

Pono ka lāʻau ʻo Mikardis e kuhikuhi i kahi kauka a hiki ke hoʻohana kūʻokoʻa a me nā lāʻau ʻē aʻe kahi i manaʻo ʻia ai kā lākou hana e hoʻomaikaʻi ai i ka hana o ke ʻano o ka ʻōnaehana cardiovascular. Kūleʻa ka mea hana i ka hana o kēlā me kēia lā e kaupalena ʻia i hoʻokahi papa Mikardis me 40 mg o ka mea ikaika.. ^ E Ha yM. Akā e pono e noʻonoʻo i nā mea maʻi ma ka maʻi hypertension iki hoʻi, ke ʻano mau nei ka hopena hypotensive i ka wā e lawe ana i ka lāʻau i kahi maʻi o 20 mg.

Ke lawe ʻia nei ke koho ʻana i kahi pōkole therapeutic no nā liʻiliʻi he 4 mau pule. Pono kēlā i ka nui o ka manawa no ka lāʻau lapaʻau e hōʻike i kāna hopena therapeutic piha. Inā ʻaʻole i loaʻa ka hopena makemake i kēia manawa, a laila e kuhikuhi ʻia ka mea maʻi e lawe iā Mikardis 80, hoʻokahi papa pākahi i kēlā me kēia lā. Ma nā hoʻohālike koʻikoʻi o ka hypertension, 160 mg o telmisartan e kuhikuhi ʻia, ʻo ia hoʻi, e lawe i ʻelua papa o 80 mg pākahi.

I kekahi mau hihia, ʻaʻole hiki ke hoʻokō ʻia ka emi ʻana o ka hoʻokahe koko i ka wā e hoʻohana ai i ka lāʻau hoʻokahi. ʻAno ke kauka i nā mea maʻi e kūʻai iā Mikardis hoʻohui, mahalo i ka diuretic komo i loko o kēia huahana, e hoʻohaʻahaʻa ka wikiwiki a ʻoi aku ka maikaʻi. Koho ʻia ka make o ka lā hui hoʻohui ʻia e pili ana i ka paʻakikī o ke ʻano o ka maʻi hypertension. Nā hōʻoia ʻana o ka mycardis me ka hōʻoia i ka hopena antihypertensive hou aʻe.

Lawe ʻia ka lāʻau lapaʻau i kēlā me kēia manawa o ka lā, ʻaʻole ʻai e ʻai i ka nalo ʻana o nā ʻāpana o ka lāʻau. ʻO ka manawa maʻamau o ka hoʻokomo ʻana e hoʻoholo ʻia e ke kauka, ma muli o ka pono o ka mea maʻi, hiki i ke kauka ke ʻōlelo aku i ka huli ʻana i ka pakanui mālama o 20 mg.

Pehea e pili ai ʻo Mikardis i nā lāʻau lapaʻau ʻē aʻe

Inā pono e hoʻohana i nā lāʻau lapaʻau me ka telmisartan, pono ke ʻike e ke kauka he aha nā lāʻau lapaʻau e lawe nei i ka mea maʻi. Me ka hoʻokūkū pinepine ʻana o nā lāʻau lapaʻau, hiki i ka hopena a i ʻole ka hopena o Mikardis ke hoʻonui.

• Hoʻonui ka Telmisartan i nā waiwai antihypertensive o nā lāʻau lapaʻau'ē aʻe me kahi hopena like,
• Me ka noʻonoʻo like me Digoxin a me Mikardis, ke piʻi ʻana o ka ʻike o nā ʻāpana o ka lāʻau mua
• Hoʻonui ʻia ke koʻo o Ramipril i ka manawa he 2.5 mau manawa, akā ʻaʻole i hoʻoholo ʻia ka manaʻo koʻikoʻi o ka hopena hui o nā lāʻau ʻelua.
• ʻO ka pākeleka o ke kaona o nā huahana e loaʻa ana ka lithium ka nui, ka mea i hui pū ʻia e ka hoʻonui ʻia o nā hopena o nā pakanā i ke kino,
• Me ka hoʻokūkū pinepine ʻana o nā NSAID a me telmisartan i nā poʻe maʻi me ka maʻi dehydration, hoʻonui i ka nui o ka hoʻomohala ʻana i ka hiki ʻana o ka renal a me ka hoʻēmi ʻana i ka hopena hypotensive o Mikardis.

ʻO ka hopena o ka hana ikaika ma ka hiki ke hiki ke mālama i nā mīkini paʻakikī

ʻO ka ʻōlelo aʻo hoʻopili no ka hoʻohana ʻana o Mikardis 80 mg a me 40 mg e hōʻike ana ʻaʻole i hōʻike ʻia nā hoʻokolohua kūikawā i ke ʻano o ka lawe ʻana i ka lāʻau lapaʻau e pili ana i ka nānā ʻana o kekahi kanaka a me ka wikiwiki o kāna hana. Eia naʻe, i ka wā e lawe ai i ka lāʻau lapaʻau me ka hana hypotensive o ka hana, pono ʻoe e hoʻomanaʻo e hoʻomanaʻo pinepine i nā lāʻau lapaʻau o kēia pūʻulu i ka hiamoe a me ka diilo mau manawa. Inā pili nā limahana i ka lawelawe ʻana i nā mea aʻoaʻo loina, a laila e hāʻawi ʻia lākou i ka analogues o mycardis.

Nā hiʻohiʻona

Pono e mālama i ka lāʻau ma kahi e kū ʻole ʻia ai nā keiki. ʻAʻole pono nā kiʻekiʻe o ka wahi mālama i ke kiʻekiʻe o 30 mau kekelē. Mālama ʻia nā papa me kahi dosage 40 a me 80 mg me ka ʻole e hōʻino i ka kūlike o ka moʻo ʻana no ka ʻoi aku ka 4 makahiki mai ka lā o kā lākou hana. 20 mau papa pōkole he 20 mau pōkole i kona ola no nā makahiki 3.

Kūlaʻi ke kumukūʻai o Mikardis ma muli o ka loaʻa ʻana o nā mea ikaika i ka lāʻau. Oe ke kuai iā Mikardis 40 me nā papa he 14 no ka pā no ka 500 a me nā rubles. Oe ke kuai iā Mikardis 80 me nā papa he 28 i loko o nā lāʻau lapaʻau ma ka awelika no 950 rubles. ʻO ke kumukūʻai o ka mycardis a me nā papa he 28 e hoʻomaka ana mai 850 mau rubles.

Ma keʻano holoʻokoʻa, he maikaʻi nā loiloi e pili ana i ka lāʻau ʻo Mikardis - nā poʻe e hoʻohana ana i ka lāʻau lapaʻau i kahi ulu ʻana o ka liʻiliʻi o nā hopena o ka ʻaoʻao a me ka kahe wikiwiki ʻana i ke koko. Akā i ka nui o ka loaʻa ʻana o kēia lāʻau lapaʻau ke kāpae ʻia i kona kumukūʻai nui.

Pono ke kauka e koho i nā kaona pono o kaʻu mycardis, nā mea kaulana loa me ka hopena like ʻole: