I nā keiki a me nā wā'ōpiopio ma lalo o 18 mau makahiki o ka male ʻana, ka hapai, ka lactation (wā o ka umauma), ka hypersensitivity i ka lāʻau lapaʻau.

Me ka akahele, e kuhikuhi i nā papa o ka lāʻau lapaʻau no ka epileptic syndrome (me ka mōʻaukala), epilepsy, hōʻemi ate, ʻeha o ka hoʻokō o ka manawa QT.

Moxifloxacin

Moxifloxacin: nā ʻōlelo e hoʻohana ai a e loiloi

Latin inoa: Moxifloxacine

ATX Code: J01MA14

ʻOihana papa: moxifloxacin (moxifloxacin)

Mea Hana: Verteks AO (Lūkia), Hetero Labs Limited (India), PFK Alium, LLC (Russia), Virend International, LLC (Russia), Promomed Rus, LLC (Lūkini)

Hoʻohou i ka wehewehe a me ke kiʻi: 11/22/2018

ʻO nā kumukūʻai i nā lāʻau lapaʻau: mai 396 mau rubles.

ʻO Moxifloxacin kahi hana antio o nā hāmeʻe ākea o ka laulā o ka hana bactericidal.

Ka hana lāʻau lapaʻau

Kahi kikowaena antimicrobial mai ka hui o nā fluoroquinolones, hana bactericidal. Hoʻāla ia i ka pālahalaha o nā micro-positive a me ka gram-negative microorganisms, anaerobic, acid-resistant a atypical bacteria: Mycoplasma spp., Chlamydia spp., Legionella spp. Hoʻomaopopo i ka hoʻouluʻana i nā maʻi maʻi bacterial pale i ka beta-lactams a me nā macrolides. ʻO ka hoʻoikaika i ka hapa nui o nā microorganisms: gram-positibo - Staphylococcus aureus (me nā ʻōpala ʻaʻole i hōʻakeʻeu i ka methicillin), Streptococcus pneumoniae (e komo pū ana me nā māla pale i ka penicillin a me nā macrolides), Streptococcus pyogenes (pūʻulu A), gram-negatif - Haemophilus influenzae a me nā non-beta-lactamase-paggawa i nā kailima), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (me nā pūnaehana like-beta a me ka non-beta-lactamase e hana nei i ka mana), Escherichia coli, Enterobacter cloacae, pyponia atypical Chlamydia.

Nā hopena hopena

Mai ka pūnaehana hana ʻana: ka ʻeha o ka ʻōpū, ka ʻōpū, ka ʻōpū, ka luaʻi, ka dyspepsia, ka lemela, ka constipation, ka nui o ka hana o ka transaminases hepatic, nā ʻilua.

Mai ka ʻaoʻao o ka pūnaehana hoʻonāwili a me ka ʻōnaehana o peripheral: dizziness, insomnia, palupalu, hopohopo, asthenia, headache, tremor, paresthesia, ʻeha ʻeha, ʻehaʻeha, hoʻopuka, ka naʻau.

Mai ka pūnaehana cardiovascular: tachycardia, peripheral edema, hoʻonui i ke koko, palpitations, ʻeha ʻeha.

Ma ka ʻāpana o nā metala kaulike: he hōʻemi i ka pae prothrombin, he hoʻonui i ka hana amylase.

Mai ka pūnaehana hemopoietic: leukopenia, eosinophilia, thrombocytosis, thrombocytopenia, anemia.

Mai ka papa musculoskeletal: ʻeha hope, arthralgia, myalgia.

Mai ka pūnaehana huaʻona: candidiasis vaginal, vaginitis.

Nā maʻi kūlou: hāpala, kala, urticaria.

Hoʻohui

Me ka hana like o nā antacids, nā minerala, hemo ʻana i ka lau o ka multivitamins (ma muli o ke ʻano o nā che chees paʻakikī me nā kuli polyvalent) a me ka hoʻēmi ʻana i ka ʻai o ka wai ma ka plasma (he hiki ke lawelawe ʻia i ka manawa like o 4 mau hola ma mua a i ʻole 2 mau hola ma hope o ka lawe ʻana i ka lāʻau).

I ka hoʻomaʻamaʻa ʻia me ka lāʻau lapaʻau inā hoʻohana ʻia nā fluoroquinolones, hiki i ke kūkulu ʻana i nā hopena phototoxic.

Hoʻopau ke Ranitidine i ka laweʻana i ka lāʻau.

Nā nīnau, nā pane, nā loiloi ma Rotomox

ʻO ka ʻikepili i hāʻawi ʻia e hana no nā lāʻau lapaʻau a me nā lāʻau lapaʻau. Aia nā ʻike e pili ana i ka lāʻau lapaʻau e pili ana i nā ʻōlelo i hoʻopili ʻia e ka mea hoʻopiʻi e ka mea hana. ʻAʻohe ʻikepili i hoʻopili ʻia ma kēia a ʻole kekahi ʻaoʻao o ka pūnaewele a mākou e hiki ke lawelawe ma kahi kūʻokoʻa no ka hoʻopiʻi pilikino i ka loea.

Pehea e hoʻohana ai i ka lāʻau lapaʻau Rotomox 400?

ʻO Rotomox 400 kahi hui o ka antimicrobials. ʻO kēia kahi mea hoʻonani hoʻokahi. Hoʻopili ʻia nā papa ma ka hoʻolōʻihi i ka hoʻokuʻu o ka mea hana. Hoʻohana ka lāʻau i ka hakakā ʻana i nā microorganisms maikaʻi loa, ka mea i hōʻike ʻia e ka pale ʻana i kekahi mau mea maʻi ʻē aʻe, no ka laʻana, macrolides. I ka hoʻolālāʻana o ka lāʻau lapaʻau, hoʻopili ʻia ka nui o ke ʻano o ka mea ikaika (400 mg).

E hoʻokuʻu i nā palapala a me ka ʻano

Hōʻā ʻia ka lāʻau lapaʻau ma ka ʻano paʻa. Nā papa papa i 400 mg o ka mea ikaika. Ma kēia hana, e hana ai nā moxifloxacin. Eia naʻe ka lāʻau i kekahi mau mea ʻē aʻe, ʻaʻole naʻe lākou e hōʻike i ka hana antibacterial, akā hoʻohana ʻia e hana i ka lāʻau o ke ʻano like ʻole o ka mea i makemake ʻia. E pili ana kēia:

ʻano keʻa mahina
mikuleka
sodium methyl parahydroxybenzoate,
ka leʻaleʻa talcum
konekena stearate,
silica colloidal
ʻO ka māka sodium carboxymethyl.

Hāʻawi ʻia ka lāʻau lapaʻau i loko o nā pūpū me nā 5 pcs. ʻO nā pōpō.

Pehea e hoʻohana ai i moxifloxacin no ka maʻi maʻi?

Lapaʻau lāʻau

Hoʻopā koke ka waiwai i ka mea i loko o ka mana o ka lāʻau. Eia nō naʻe, Hoʻopili maoli kēia mea hana. ʻAʻole emi ka kiʻekiʻe o kēia kaʻina hana i ka wā e ʻai ai. Loaʻa ka maikaʻi o ka lāʻau lapaʻau me ka bioavailability kiʻekiʻe (hiki i ka 90%). Hoʻopili ka mea hana ikaika i nā protein i loko o ka plasma. ʻAʻole iʻoi aku ka nui o moxifloxacin e kokoke ana i ka 40% o ka nui o ka neʻe i pili i kēia hana.

Loaʻa ka kiʻekiʻe o ka hana i kekahi mau hola ma hope o hoʻokahi mau kiko o ka paila. Loaʻa ka hopena therapeutic kiʻekiʻe loa i nā lā 3 ma hope o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa. Hoʻomaopopo ʻia ka mea ikaika ma ke kino holoʻokoʻa, akā no ka mea i nui aʻe ka hōʻuluʻulu i loko o nā ʻōpū, bronchi, sinuses. Ma ke kaʻina hana o ka hana o ka hana o ka mūʻai, e hoʻokuʻu ʻia nā pūhui lohi. Ke loli ʻole ʻo Moxifloxacin a hoʻopili ʻia ka metabolites ma o ke ake i ka wā o ka urination a me ka defecation. Hoʻohana pū ka lāʻau i ka mālama ʻana i nā wahine a me nā kāne.

ʻAʻole emi ka kiʻekiʻe o kēia kaʻina hana i ka wā e ʻai ai.

Nā hōʻailona no ka hoʻohana ʻana

Hāʻawi ʻia ka hōʻiliʻili o ka mea ikaika i ka nui o ka māka, bronchi a me nā sinuses, hāʻawi ʻo Rotomax i ka hopena maikaʻi loa i ka mālama ʻana i nā hanana hanu. Akā, hiki i ka lāʻau lapaʻau ke hoʻokō i kahi hopena maikaʻi i ka mālamaʻana i nā kūlana pathological ʻē aʻe. Nā hōʻailona no ka hoʻohana ʻana:

ʻānō bronchitis me ka exacerbation,
ʻO ka maʻi mākia (ua ʻae ʻia ka lāʻau lapaʻau i ka wā o ka mālama ʻana ma ke kumu outpatient a i ʻole ma ka hale).
nā maʻi o nā ʻōpū pelvic i hoʻonāukiuki ʻia e nā microorganisms maikaʻi ʻole (ʻoi ʻia ka lāʻau inā ʻaʻole nā hoʻopiʻi).
nāʻiʻi o ka ʻili a me nā pāwī palupalu,
ʻānōitisitisitis
paʻakikī paʻakikī intra-ʻōpū.

E hoʻokuʻu i ke ʻano a me ka ʻano

Nā palapala ʻano o moxifloxacin:

nā papa hana ʻoniʻoni: biconvex, ma muli o ka mea hana: ʻano like me ka capsule, me ka bevelled, mai ka ʻalani ʻulaʻula a me ka ulaula, i kahakaha ʻia me "80" ma ka ʻaoʻao a me ka "I" ma ka ʻaoʻao, a i ʻole ka pua i ka melemele i nā papa āpau. i loko o ka ʻāpana - ʻo ka kiko mai ka ʻele i ka melemele i ka melemele (5, 7 a i ʻole 10 mau ʻāpana i kēlā me kēia mea i kahi blister, i kahi pūlō pepa o 1, 2 a i ʻole 3 blisters, 5, 7, 10 a i ʻole 15 mau ʻāpana i loko o kahi pā kuhi, i ka pōpō kāleka he mau papa he 1,6 mau ʻāpana, 10 mau ʻāpana i kēlā me kēia ke kaila, i loko o kahi pūpū o ke kāleka 1 mau).
ʻO ka infusion solution: kūpaʻa, ʻeleʻele i ka melemele wai melemele (50 ml kēlā me ke kīwaha kīwaha ʻole color, 5 mau pahu i loko o kahi pā kāleka, 250 ml i loko o nā haki wai, i loko o kahi pahu pahu kākahi 1 paha i loko o a i ʻole kahi kāmeʻa i hoʻopaʻa ʻia me ka hermetically i hoʻopaʻa ʻia iā ia, no nā hale hoʻokipa - 196 mau hūlū ʻole me nā pā mi i nā pahu i hoʻopaʻa ʻia ʻole a i ʻole ia me ka pahu pahu.

Pākaukau 1 papa:

mea waiwai: moxifloxacin hydrochloride - 436.4 mg (e pili ana i nā ʻike o moxifloxacin - 400 mg),
Nā kumuhana hou: povidone K29 / 32 a i ʻole K-30 (Kollidon 30), cellulose microcrystalline, magnesium stearate, sodium croscarmellose, pili i ka mea hana, hoʻohui - lactose monohidate, talc a me silicon dioxide colloidal,
haʻi ʻoniʻoni (e pili ana i ka mea hana): Opadry II ʻula 85F23452 ka waiʻona polyvinyl ka wai ʻona, titanium dioxide, macrogol, talc, ka aniani o ka lā me ka alumini varnish (E110), ka hao oxide dye ulaula (E172) a i ʻole ʻāpana ʻulaʻula 02F540000 hypromellose 2910, titanium dioxide (E171), macrogol, iron oxide dye red (E172), iron oxide dye yellow (E172) a i ʻole no ka hoʻohuihui maloʻo no ka uhi kiʻi ʻana o ka hypromellose, ka hao oxide melemele (iron oxide), hyprolose (hydroxypropyl cellulose), titanium dioxide, talc.

I ka 1 ml o ka hoʻonā ai no ka hoʻopili i nā:

mea waiwai: moxifloxacin hydrochloride - 1.744 mg (ma nā ʻōlelo o ke kumu moxifloxacin - 1,6 mg),
Nā kumuhana hou: sodium klorida, wai no ka ʻoa, ʻo ka sodium hydroxide solution a i ʻole ka hopena o ka wai hoʻoleina hydrochloric, a i ʻole ((hilinaʻi ʻia i ka mea hana) disodium ka paʻakai o ka ethylenediaminetetraacetic acid (sodium hydroxide solution a i ʻole ka wai ʻomo hydrochloric - hoʻohana inā pono e hoʻoponopono i ka waiwai pH i ka hana).

Pākuʻi helu

Nā papa hana ʻaniʻoniʻoni, 400 mg

Aia ma ka papa papa

mea waiwai - moxifloxacin hydrochloride 436.322 mg (e like me moxifloxacin 400.00 mg),

nā mea hoʻohālikelike: nā keena palaoa, microcrystalline cellulose, sodium starch glycolate, sodium methylhydroxybenzoate, colloidal silicon dioxide, talc, magnesium stearate

ʻili kūpeʻe: Opadry ulaula 85F540146 (polyvinyl waiʻona, titanium dioxide (E171), macrogol, talc, ka hao hao oxide (E172).

ʻO nā papa papaʻaina i ulana ʻia i ke kala, me ka pilikia me kekahi ʻaoʻao.

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, ua hoʻomoʻi pinepine ʻia ka moxifloxacin a kokoke loa. ʻO ka bioavailability piha e pili ana i ka 91%.

Ma hope o hoʻokahi kaʻe o 400 mg o moxifloxacin, ua hōʻea ka nui o ka nui (Cmax) i loko o ke koko i loko o nā hola 0.5-4 a he 3.1 mg / l.

ʻO ke kiʻekiʻe a me ka liʻiliʻi o ka hoʻoliʻi plasma i loko o kahi kū mau (400 mg i hoʻokahi manawa i kēlā me kēia lā) he 3.2 a me 0.6 mg / L, kēlā. I ke kūlana paʻa, ka ʻike o ka lāʻau i ka wā o ka wā ma waena o nā hōʻeha o ka lāʻau lapaʻau ma kahi o 30% e kiʻekiʻe aʻe ma mua o ka hopena mua.

Ka hoʻolele nui ʻia ʻo Moxifloxacin i ka nui o ka lawena, ma hope o ka lawe ʻana i ka 400 mg o ka lāʻau lapaʻau, ʻo ka wahi ma lalo o ka pāpaʻi pharmacokinetic (AUC) he 35 mg / h / L. ʻO ka nui o ka hoʻoili ʻana o ka puʻukepili (Vss) ma kahi o 2 L / kg. I loko o nā hui vitro a ma nā vivo, ʻo ka hoʻopaʻa ʻana o ka moxifloxacin i nā protein plasma he 40-42%, ʻaʻohe o ka ulu ʻana o ka lāʻau. Hoʻopili pinepine ʻia ʻo Moxifloxacin i ka album serum.

ʻO nā mea kikoʻī i hoʻoili ʻia (kahi geometric mean) i nānā ʻia ma hope o ke kaʻi ʻana i hoʻokahi mahele waha o moxifloxacin, 400 mg:

Kahu

Nā kikowaena

ʻO ka hoʻohālikelike o ka loaʻaʻana o ka lāʻau i ka kiko i kona paʻa ʻana i ka plasma

Hoʻomoe Litila Epithelial Lining

ʻ .lelo Etmoid

Wahine wahine ʻōneʻomaʻa *

* ka hoʻokō ʻana i loko o kahi pākahi o 400 mg

1 10 mau hola ma hope o ka lawelawe ʻana i ka lāʻau

2 hoʻopaʻa ʻana o ka waiwai manuahi

3 mai 3 mau hola i 36 mau hola ma hope o ka hoʻokele ʻana

4 ma ka hope o ka hoʻopou

Moxifloxacin e hana i ka biotransformation o ka lua hana a ua hoʻopio ʻia ma o nā ʻōpū a me ke ola o ka gastrointestinal i loli ʻole, a me ke ʻano o ka sulfo-pūpū (M1) a me glucuronide (M2). Hoʻopili wale kēia mau metabolites i ke kino o ke kanaka a ʻaʻohe ka hana antimicrobial. ʻO kahi hōʻike i ka pilina o ka metabolic pharmacokinetic me nā lāʻau lapaʻau ʻē aʻe i hōʻike ʻia no ka moxifloxacin ʻaʻole biotransformed e ka microsomal cytochrome P450. Hōʻike nā mea hōʻike o ka hoʻomehana oxidative.

ʻO ka hapalua-ola o ka lāʻau mai ka plasma ka mea ma kahi o 12 mau hola. Ka awelika huina o ka holo ʻana ma hope o ka lawe ʻana i ka papa kau o 400 mg ka 179 i 246 ml / min. ʻO ka hoʻomaʻamaʻa Renal, ma kahi o 24-53 ml / min, e loaʻa ana e ka ʻāpana palaki reabsorption o ka lāʻau i loko o nā keiki.

ʻO ka hoʻohana pū ʻana o ka ranitidine a me ka probenecid ʻaʻole i pili i ka hoʻomaʻemaʻe ʻole o ka hana a ka lāʻau.

ʻO ke ʻano o ke ala o ka hoʻokele ʻana, ʻoi aku ka nui o ka moxifloxacin ma kahi o 96-98% a me ka metabolism o ke kaina o ka lua o ka hoʻokūkū me ka ʻole o nā hōʻailona o ka metabolism oxidative.

Pharmacokinetics i loko o nā hui hoʻomanawanui

I nā mea hana olakino olakino me ko ka nui o ke kino (no ka laʻana, nā wahine) a me nā mea hana ma mua, ua ʻike ʻia nā mea kiʻekiʻe o ka plasma.

ʻAʻole maikaʻi loa nā huahana pharmacokinetic o moxifloxacin i loko o nā mea maʻi me ka hiki ʻole o ka renal (ʻoiai hoʻi me ka clearance creatinine> 20 ml / min / 1.73 m2). Me ka hoʻohaʻahaʻa ʻana i ka hana renal, hoʻonui i ke kahe o ka metabolite M2 (glucuronide) e kahi kumu o ka 2.5 (me ka hana ʻana o creatinine o 50% i hoʻokahi a ʻoi paha mau ʻāina.

ʻLoe a me ke kākele

ʻO ka regimen dosis papa ʻia ʻo 400 mg hoʻokahi mau lā (250 ml o ka hoʻonā no ka infusion). Mai pā i ke ʻano momona.

I nā hoʻomaka mua o ka hoʻōla, hiki ke hoʻohana ʻia kahi hopena no ka infusion, a laila, e hoʻomau i ka hoʻolaʻa ʻana, inā loaʻa nā hōʻailona maʻi, hiki ke kuhikuhi ʻia ka lāʻau lapaʻau ma nā papa.

Loaʻa i ka maʻi pneumonia kaiaulu - ka lōʻihi o ka mālama ʻia no ka mālama ʻana i nā hana pae (intravenous i ukali ʻia e ka hana waha) ʻo 7-14 mau lā.

ʻEha a pulu nā ʻōwili a me nā maʻi ʻeha - ka lōʻihi o ka lōʻihi o ka mālama ʻana i ka hana lapaʻau (intravenous i ukali ʻia e ka hana waha) ʻo 7-21 mau lā.

ʻAʻole iʻoi aku i ka lōʻihi o ka mālama ʻia.

Na keiki a ʻōpio

Hoʻopili ʻia ʻo Moxifloxacin i nā keiki a me nā ʻōpio. ʻAʻole paʻa i ka hopena a me ka palekana o moxifloxacin i nā keiki a me nā ʻōpio ma lalo o ka makahiki 18.

ʻO nā maʻi maʻi

ʻAʻole pono ke hoʻololi ʻana i ka hoʻoponopono ʻia i ka poʻe maʻi maʻi.

ʻAʻole pono nā loli o ke koho ʻana i ka ʻohana i nā ʻano ʻē

ʻO nā mea maʻi me ka hana pūlima hemahema

ʻAʻole lawa nā ʻike e pili ana i ka hoʻohana ʻana i nā mea maʻi me ka hana aho lēwa.

ʻO nā mea maʻi me ka maʻi lēwa pʻōpiopio

I ka poʻe maʻi me ka renal maikaʻi ʻole (e komo pū ana me ka clearance creatinine 5 mau manawa kiʻekiʻe o ka maʻamau.

Hoʻopili i nā lāʻau lapaʻau

Nā Hoʻohui Kūʻai

Hiki ke noʻonoʻo pono i ka hopena hoʻohui o ka hoʻonui i ka palena QT i ka wā e lawe ai i ka moxifloxacin a me nā lāʻau lapaʻau e hiki ke hoʻonui i ke kikowaena QTc. Ma muli o ka hoʻohana pū ʻana o ka moxifloxacin a me nā lāʻau lapaʻau e hoʻopili ai i ka palena o QT, ʻo ka piʻi ʻana o ka hoʻouka ʻana i ka arrhythmias ventricular, me ka tachycardia polymorphic ventricular (torsade de pointes), hoʻonui ʻia.

ʻO ka hoʻohana ʻana i ka moxifloxacin me kekahi o kēia mau lāʻau lapaʻau ua contraindicated:

- Nā papa IA antiarrhythmic drug (e.g., quinidine, hydroquinidine, disopyramide)

- Nā Papa III antiarrhythmic drug (e.g., amiodarone, sotalol, dofetilide, ibutilide)

antipsychotics (e.g. fenothiazines, pimozide, sertindole, haloperidol, sultoprid)

- kekahi mau mea antimicrobial (saquinavir, sparfloxacin, iv erythromycin, pentamidine, antimalarials, ma nā halofantrine kūikawā)

- kekahi mau antihistamines (terfenadine, astemizole, misolastine)

- nā mea'ē aʻe (cisapride, vincamine iv, bepridil, diphemanil).

Pono ka Moxifloxacin e makaʻala me ka makaʻala i nā mea maʻi e lawe i nā lāʻau hōʻoki i ka paʻakai (no ka laʻana, ka loop a me ka thaizide diuretics, laxatives, enemas (ma nā helu koʻikoʻi), corticosteroids, amphotericin B) a i nā lāʻau lapaʻau e pili ana i ka bradycardia koʻikoʻi. ʻO ka kikowaena ma waena o ka lawe ʻana i nā mākaukau e loaʻa ana i nā cation divalant a trivalent paha (no ka laʻana, ʻo nā antacids e loaʻa ana i ka magnesium a i ʻole alumini, nā kiki didanosine, sucralfate a me nā hoʻomākaukau e pili ana i ka hao a zinc) a me ka moxifloxacin e pili ana i ka 6 mau hola.

I ka lawelawe ʻia ʻana o ka moxifloxacin i ka lawelawe ʻana i nā mea momona, ua hoʻonui ʻia ka nui o ka konsentrasi (Cmax) o ka digoxin ma kahi o 30%, aʻo ka wahi ma lalo o ka pihi-mākeke (AUC) a me ka liʻiliʻi liʻiliʻi (Cmin) o ka digoxin ʻaʻole i loli.

Hōʻike nā hualoaʻa o nā noi i hana ʻia me nā poʻe hana maʻi me ka maʻi diabetes mellitus me ka hoʻonaninani waha i ka moxifloxacin a me ka glibenclamide, ua hoʻemi ʻia ka ʻike o ka glibenclamide i ka plasma koko e like me ka nui o 21%, ka mea hiki ke alakaʻi i ka hoʻomohala ʻana i kahi ʻano maʻalahi o ka hyperglycemia transient. Eia nō naʻe, ʻaʻole i alakaʻi nā loli pharmacokinetic i nā loli i nā paramacodynamic parameter (glucose o ke koko, ka insulin).

Hoʻololi i ka INR (hoʻokūkū maʻamau o ka honua)

I nā mea maʻi e loaʻa ana i nā anticoagulants e hui pū me nā māmai (antibacterial agents) (ʻoi aku ka fluoroquinolones, macrolides, tetracyclines, cotrimoxazole a me kekahi cephalosporins), aia nā hihia o ka hana anticoagulant o nā hana anticoagulants. ʻO nā mea makaʻi ka hele ʻana o kahi maʻi ʻeha (a me kahi kaʻina hoʻopihapiha hoʻohālikelike), ka makahiki a me ke ʻano maʻamau o ka mea maʻi. I kēia mea, paʻakikī ke nānā ʻana i ka maʻi a i ʻole ka hōʻola ʻana i hoʻokau hewa ʻole INR. Pono e alakaʻi pinepine i ka nānā ʻana o ka INR a, inā pono, hoʻoponopono i ka nui o nā lāʻau lapaʻau oral anticoagulant.

Ua hōʻike ʻia nā haʻawina haukapila i ka hapa ʻole o ka pilina me ka hoʻohana pinepine ʻana i ka moxifloxacin a me kēia mau lāʻau lapaʻau: ranitidine, probenicide, contraceptives waha, additives-calcium, hoʻohui ʻia no ka hoʻohana makua, theophylline, cyclosporine a itraconazole.

Ma nā haʻawina vitro me nā cytochrome P450 enzymes e hōʻoia i kēia mau ʻike. Hāʻawi i kēia mau hualoaʻa, hiki ke hoʻopau ʻia i ka pilina o ka metabolic e pili ana i ka huina o ka cytochrome P450.

Hoʻohui pili i nā meaʻai

ʻAʻohe hui koʻikoʻi ʻo Moxifloxacin me ka meaʻai, ʻo ka huahana huahana.

ʻAʻole hoʻohālikelike i kēia mau ʻōnaehana hou ʻana me ka hopena moxifloxacin: ʻoi aku ka hopena o ka sodium chloride 10% a me 20%, sodium bicarbonate solution 4.2% a me 8,4%.

Nā ʻōlelo kikoʻī

Loaʻa ka pono o ka mālama ʻana me ka moxifloxacin, ʻoi aku ka maʻi ʻoluʻolu a me ke kala ʻana i ka maʻi e ʻike ʻia ma kēia ʻāpana.

ʻO ka lōʻihi o ke anuanu o ka QTc a me nā kūlana e pili ana i nā maʻi maʻi i pili i ka lōʻihi o ke kikowaena QTc

Ua hoʻokūpaʻa ʻia e hoʻonui ka moxifloxacin i ka manawa QTc ma ka electrocardiograms o kekahi mau maʻi. ʻO ka hoʻonui ʻia o ka hoʻonui QT ke hoʻonui me ka hoʻonui ʻana i ka hoʻōla kūkā ʻana i ka plasma koko ma muli o ka infusion intravenous infusion. ʻO ke hopena, pono ka lōʻihi o ka infusion ma kahi o nā minuke 60 i ʻōlelo ʻia ma mua o ka nui o ka nui o ka inika o 400 mg hoʻokahi i ka lā.

Ma muli o ka makemake ʻana o nā wahine e hoʻolōʻihi i ka kikowaena QTc i hoʻohālikelike ʻia, hiki paha iā lākou ke nānā aku i nā lāʻau lapaʻau e hoʻonui ana i ka manawa QTc. Hiki i nā maʻi ʻōpio ke hoʻomaopopo i ka hopena o nā lāʻau lapaʻau e hoʻonui ana i ka manawa QT.

Pono e hoʻohana ʻia nā lāʻau lapaʻau e hōʻemi i ka potassium me ka mālama ʻana i nā maʻi i loaʻa i ka moxifloxacin.

Pono ke hoʻohana ʻana ʻo Moxifloxacin i ka mālama ʻana i nā poʻe maʻi me ka hoʻomau mau ʻana i nā kūlana proarrhythmogenic (ʻoi aku ka nui o nā wahine a me nā poʻe maʻi maʻi maʻi), e like me ka ischemia myocardial akolu a i ka hoʻolōʻihi ʻana o ka wā QT, no ka mea, ua hiki ke alakaʻi i kahi nui o ka arrhythmias ventricular (komo i ka pirouette tachycardia) a me ka hopu lima. Hiki i ka nui o ka hoʻonuiʻana i ka palena QT ke hoʻonui me ka hoʻonui nui o ka lāʻau. No laila, ʻaʻole iʻoi aku i kahi kau i hāʻawi ʻia.

Inā aia he mau hōʻailona o ka arrhythmia cardiac i ka wā mālama, pono ʻoe e hoʻokaʻawale i ka lawe ʻana i ka lāʻau a hana i kahi ECG.

Ua kākau ʻia ka hypersensitivity a me nā hopena o ka maʻi ma hope o ka hoʻokō mua o ka fluoroquinolones, me ka moxifloxacin.

Kuhi iki aku paha, hiki i nā hopena anaphylactic ke holomua i ka hoʻoweliweli o ka anaphylactic hoʻoweliweli, i kekahi mau hihia ma hope o ka hoʻohana mua ʻana o ka lāʻau. I kēia mau hihia, pono e hoʻoneʻe ʻia ka lawelawe ʻana o ka moxifloxacin a me nā mea pono e pono ai ka lāʻau (me ke ʻano anti-shock).

ʻO ka hoʻohana ʻana i nā lāʻau quinolone e pili ana i ka hiki i ka hoʻomohala ʻana i ka lawe ʻaʻi ʻana. Pono e mālama pono ʻia i ka mea maʻi me nā maʻi pili o ka pīpī, a i mua paha o nā mea ola ʻē aʻe e wānana ana i nā kahawai a i ʻole e hoʻohaʻahaʻa i ka paepae hoʻoiho. I kahi hihia, hiki ke hoʻokaʻawale ke keʻena o moxifloxacin i kahi hana lapaʻau i ʻōlelo ʻia.

Ua hōʻike ʻia nā hōʻike o ka sensory a i ʻole ka sensorimotor polyneuropathy, e alakaʻi ana i ka paresthesia, hypesthesia, dysesthesia, a i ʻole nāwaliwali i nā mea maʻi e loaʻa ana i nā quinolones, me ka moxifloxacin. Ma kahi o nā hōʻailona o ka neuropathy, e like me ka ʻeha, ke kuni ʻana, ke nānā ʻana, ka ʻāʻī a nāwaliwali paha, nā mea maʻi e lawe ana i ka moxifloxacin e ʻōlelo aku i kekahi kauka ma mua o ka hoʻomau ʻana i ka mālama ʻana.

Hiki i nā hopena noʻonoʻo ka hopena ma hope o ka hoʻohana mua ʻana o nā quinolones, e komo pū me ka moxifloxacin. I nā hihia ākea loa, piʻi ka manaʻo a i ʻole ka psychotic réaction i ka manaʻo suicidal a me ke ʻano me ka manaʻo e hoʻoweliweli iā lākou iho, e like me ka hoʻāʻo ʻana ma ka pepehi ʻana. Inā kūkulu ka mea hoʻomanawanui i kēlā mau hopena, pono e hoʻoneʻe a moxifloxacin i nā hana kūpono. Aapaʻa ʻia e makaʻala ʻē loa i ka wā e kuhikuhi ana i ka moxifloxacin i nā mea maʻi psychotic a i nā mea maʻi me ka mōʻaukala o nā maʻi noʻonoʻo.

Ke hoʻohana nei i ka moxifloxacin, ua hōʻike ʻia nā hihia o ka hoʻomohala o ka hepatitis fulminant, hiki i ka pilikia ke nānā aku i ke ola hōʻeha ola, me ka hopena o ka mea make. Pono e kamaʻilio mua nā mea maʻi i kahi kauka ma mua o ka hoʻomau ʻana i ka mālama ʻana inā aia nā hōʻailona a me nā hōʻailona o ka hepatitis fulminant, e like me ka hoʻomohala koke ʻana i ka asthenia e pili ana i ka jaundice, uliuli ʻeleʻele, heʻano i ke koko, a i ʻole hepatic encephalopathy. I ka mea e hōʻailona ai i nā maʻi o ka ate, pono ia e hana i kahi hōʻike o ka hana o ka ate.

ʻO nā kumu o ka hopena o ka ʻili o ka pūlima, no ka laʻana, ʻo ka maʻi Stevens-Johnson a i ʻole nā mea ʻole ʻia a me ka epacmalsis epidermal (e pili ana i ka ola). Inā hele mai nā hopena mai ka ʻili a me / a i ʻole nā memous mucous, pono e kiʻi koke ʻoe i ke kauka ma mua o ka hoʻomau ʻana i ka mālama ʻana.

ʻO ka ʻeha e pili ana i ka Antibiotic (AAD) a me nā colitis e pili ana i ka antibiotik (AAK), me ka colitis pseudomembranous a Hoʻolaha Clostridium- ua hōʻike ʻia nā maʻi maʻamau i pili me ka hoʻohana ʻana i nā lāʻau antibacterial ākea ākea, me ka moxifloxacin, a hiki ke ʻano loli ʻole mai ka maʻi lahilahi a i ka colitis makeal. No laila, he mea nui ka mālama ʻana i kēia maʻi ma ka maʻi i nā mea maʻi e hoʻomohala i ka maʻi kaumaha i ka wā a ma hope o ka lawe ʻana i ka moxifloxacin. Inā kānalua a hoʻopaʻa ʻia paha ʻo AAAD a, pono e hōʻea i ka lawe ʻana i ka lāʻau antibacterial, me ka moxifloxacin, a e kuhikuhi i nā hana kūpono e kūpono ai. Eia kekahi, pono e nānā ʻia nā ʻōkuhi kūpono e hōʻemi i ka hopena o ka hoʻoili ʻana. ʻO nā maʻi e hoʻomohala i kahi maʻi palupalu e contraindicated i ka lāʻau lapaʻau e pale ai i ka ʻōpū o ka wahī.

Pono ke hoʻohana ʻia ka Moxifloxacin me ka makaʻala ʻana i nā mea maʻi me ka graast myasthenia, no ka mea hiki i ka lāʻau lapaʻau ke hoʻonui i nā hōʻailona o kēia maʻi.

ʻO ka maʻi a me ka pohihihi o nā tendons (ʻoi aku hoʻi i ka tendon Achilles), i ka manawa bilateral kekahi, hiki ke hōʻeha i ka wā o ka mālama ʻana me quinolones, me ka moxifloxacin, ʻoiai ma loko o kahi mau hola 48 ma hope o ka hoʻomaka ʻana o ka mālama ʻana, a ua hōʻike ʻia nā hihia i loko o kekahi mau mahina ma hope o ka hoʻokuʻu ʻana o ka hopena. Hoʻopili ʻia ka nui o ka tendonitis a me ka tendon tendon i nā mea maʻi a me nā mea maʻi i mālama ʻia me corticosteroids i ka manawa like. I ka hōʻailona mua o ka ʻeha a me ka mumū paha, e oki nā mea maʻi e lawe i ka moxifloxacin, e hōʻoluʻolu i nā limu i hoʻopuni ʻia, a ʻimi koke aku i ke kauka e loaʻa ka kūpono kūpono (e.g. immobilization).

Ke hoʻohana nei i ka quinolones, ua ʻike ʻia nā hōʻike photosensitivity. Eia nō naʻe, ua hōʻike ʻia nā noiʻi ua loaʻa ka moxifloxacin i ka liʻiliʻi o ka photosensitivity. Eia nō naʻe, e pale i nā mea maʻi i ka ʻike ʻana i ka radiation UV a i ʻole ka lohi i ka lā i ka wā e mālama ai me ka moxifloxacin

ʻAʻole ʻōlelo ʻia ʻo Moxifloxacin no ka mālama ʻana i nā maʻi i hoʻonaninani ʻia e ka maʻi o ke ala o ka methicillin-Staphylococcus aureus (MRSA). Ma ka hopena o kahi mea i hoʻopiʻi a hōʻoia ʻia paha e mālama ʻia i ka staphylococcus methicillin, pono ia e kuhikuhi i ka mālama ʻana me kahi lāʻau lapaʻau maʻi kūpono.

ʻO ka hiki i ka moxifloxacin e kāohi i ka ulu o ka mycobacteria hiki ke hoʻopilikia i nā hopena hōʻike ma Mycobacterium spp., ke alakaʻi nei i nā hopena maikaʻi ʻole ke hoʻoili ʻana i nā mea maʻi maʻi e mālama ʻia me ka moxifloxacin i loko o kēia manawa.

E like me nā fluoroquinolones, i hoʻohana ʻia ka moxifloxacin i kahi hoʻololi i ke kaila o ka glucose o ke koko, e komo pū ana me hypo- a me hyperglycemia. I ka wā moxifloxacin therapy, dysglycemia i hana nui ʻia i ka poʻe maʻi nā maʻi me ka maʻi mellitus e loaʻa ana i ka concomitant therapy me nā huaʻōlelo hypoglycemic waha (no ka laʻana, he mau huaʻala sulfonylurea) a i ʻole insulin. Ke mālama nei i nā maʻi me ka maʻi maʻi, e mālama ʻia ka mālama ʻana i ke kaohi o ke kō.

Pono ke hoʻohana ʻia ka Moxifloxacin e makaʻala me ka makaʻala i nā poʻe maʻi me nā maʻi o ka pūpū inā ʻaʻole hiki iā lākou ke mālama i ka nui o ka kōʻai ʻana, no ka mea, hiki i ka puʻuwai ke hoʻonui i ka hopena o ka ulu ʻana o ka pūpū.

Me ka hoʻomohala ʻana o ka ʻike maka ʻole a me nā hōʻailona ʻē aʻe o nā maka, pono ʻoe e ʻimi aku i kahi kanaka ophthalmologist.

ʻO ka poʻe maʻi me ka mōʻaukala a i ʻole ka glucose maoli-6-phosphate dehydrogenase ka mea i makemake i nā hopena hemolytic i ka wā e mālama ai me ka quinolones. Pono ke ʻano o ka Moxifloxacin e makaʻala me ka makaʻala i kēia mau maʻi.

ʻO ka hopena ʻo infusion moxifloxacin no ka hoʻokele intravenous wale nō. Ua hōʻike ʻia nā haʻawina preclinical i ka loaʻa ʻana o ka ʻaihue periarterial o nā lau ma hope o ka hoʻokō intraarterial o moxifloxacin, no laila, pono e pale ʻia kēia ʻano ʻoihana hoʻokele.

ʻŌpū a me ka lactation

ʻO ka palekana o ka lawe ʻana i ka moxifloxacin i ka wā hāpai o ka wahine ʻaʻole i loiloi ʻia. Ua hōʻike nā noiʻi holoholona i nā pono o ka reproduction. ʻAʻole maopopo ka ʻike nui i ke kanaka. Ma muli o nā ʻikepili preclinical e pili ana i ka hoʻopōʻino i ka umauma o nā ʻili nui e ka fluoroquinolones i nā holoholona mua a me ka hōʻeha ʻana i nā ʻeha hui i wehewehe ʻia i nā keiki i mālama ʻia me kekahi o nā floroquinolones, ʻaʻole pono nā moxifloxacin e ʻōlelo ʻia i nā wahine hāpai.

ʻAʻole ʻike nā ʻikepili e pili ana i ka hoʻohana ʻana i ka lāʻau ma nā wahine i ka wā lactation. Ua ʻike ʻia nā haʻawina preclinical he huna ʻia nā moxifloxacin liʻiliʻi i loko o ka waiū umauma. Hoʻohana ʻia ka hoʻohana ʻana o moxifloxacin i ka wā o ka hoʻoulu ʻana.

Nā hiʻohiʻona o ka hopena o ka lāʻau lapaʻau ma ka hiki ke hoʻokau i nā kaʻa a me nā mea pilikia weliweli.

Hiki i ka lāʻau lapaʻau ke hōʻemi i ka hiki o nā mea maʻi e hoʻokau i nā kaʻa a komo i nā hana ʻē aʻe paha e koi ai i ka nānā nui a me ka wikiwiki psychomotor ma muli o ka hopena i ke kikowaena kūloko a me nā pilikia o ka ʻike.

Ke keu

Loaʻa ka ʻike ma kahi paʻa overdose.

I ka hihia o ka overdose, pono kahi e alakaʻi e ka kiʻi haumania a me ka mālama ʻana i ka mālama mālama i ka maʻi me ka nānā ʻana o ECG. ʻO ka hoʻohana ʻana i ka carbon activated no ka mālama ʻana i ka overdose ma ka waha waha a me ka infusion o 400 mg o moxifloxacin e kūpono e pale i ka hoʻonui nui ʻana i ka ʻike systemic ka moxifloxacin e ʻoi aku ma mua o 80% a 20%.

Mea hana

ʻO Scan Biotech Limited, India

Ka inoa a me ka ʻāina o ka mea hoʻopaʻa inoa palapala

Pōkuhi Loko, UK

ʻLelo i ka hui e ʻae ana i nā hoʻopiʻi mai nā mea kūʻai aku ma ka maikaʻi o nā huahana (a me nā kuleana) a no ka mālama pono ʻana i ka hoʻopaʻa inoa ʻana i ka palekana o ka lāʻau ma ka wahi o ke aupuni o Kazakhstan

ʻO St. ʻO Dosmukhametova, 89, ke kikowaena ʻoihana "Caspian", ke keʻena 238, Almaty, ke Aupuni Repubalika o Kazakhstan.

Nā hōʻikeʻike e pili ana i ka lāʻau lapaʻau

Ma ka aneane o nā loiloi a pau, ua hoʻohana ʻia ʻo Moxifloxacin e kū'ē i ke kumu kumu o ka maʻi a me ka hoʻomaikaʻi wikiwiki ʻana i ke kūlana olakino.

Akā, nui nā mea hoʻomaʻi e hoʻopiʻi e pili ana i kekahi mau hopena ma hope o ka lawe ʻana i kēia lāʻau lapaʻau. I waena o lākou, ʻo ka mea maʻamau ka mea i hōʻike ʻia: ka nausea, ka maʻi iki, ka ʻeha hōʻeha o ka ʻōpū, hōʻeha, ka ʻeha hōʻeha o ka ʻōpū, nā ʻōpū, nā ʻeha, ka tachycardia, ka ʻeha, ka hopohopo a me nā manaʻo kaumaha.

Ke haʻi nei kekahi poʻe maʻi e hōʻalo ʻia ana nā hopena ʻaoʻao e ka lawe ʻana i nā papa Moxifloxacin i ka wā o ka pāʻina a me ka inu nui o ka wai minuke ma hope o ka lawe ʻana i ka lāʻau.

Ua hōʻike ʻia e kekahi mau loiloi ka lawe ʻana mai i ka lāʻau i ka wahine ma loko o nā wahine, i hōʻiliʻili ʻia ʻia e ka lawe ʻana iā Difluzole (a i ʻole nā lāʻau like ʻole).

Hōʻike nā loiloi o Vigamox maka wai no ka hapa nui. Ua hoʻomanawanui maikaʻi lākou e nā mea maʻi a ʻaʻole i hōʻeha ka hopena. Kuhi nā mea kākau o nā loiloi i ka wikiwiki wikiwiki o ka hōʻeha ʻana o nā maka a me nā hōʻailona o ka maʻi lalo.

Loaʻa nā loiloi o ka hypersensitivity i ka hāʻule ʻana o Vigamox. I kēia mau hihia, ua ʻike ʻia nā mea maʻi i ka nānā ʻana o ka itching a ʻulaʻula i nā maka. Ma hope o ka hoʻokuʻu ʻana i ka lāʻau, hoʻopau koke kēia mau hōʻailona i ka maʻi.

Ua pane ka hapa nui o nā poʻe maʻi i ke kumukūʻai o Moxifloxacin a me nā hui e like me "ke kiʻekiʻe."

ʻO ke kumukūʻai o ka lāʻau lapaʻau ma Lūkia a me Ukraine

Ke hilinaʻi nei ke kumukūʻai o Moxifloxacin ma ke ʻano o ka hoʻokuʻu ʻana, i ka lāʻau lapaʻau a me ke kūlanakauhale e kūʻai aku i ka lāʻau lapaʻau. Ma mua o ke kūʻai aku iā ia, pono ʻoe e wehewehe i kāna kumukūʻai i loko o nā lāʻau lapaʻau āpau a nīnau aku i kāu kauka e pili ana i ka hiki ke hoʻololi me kahi analogue, no ka mea ʻo kēia lāʻau lapaʻau ka mea hiki ʻole ke ʻike mau ʻia ma ke kūʻai aku. ʻO nā manawa pinepine i ka ʻenehana kūʻai olakino lākou e kūʻai aku i nā analogues (synonyms) o Moxifloxacin ma mua o kēia lāʻau lapaʻau iho.

ʻO ke kumukūʻai kumu o nā analogues (synonyms) o Moxifloxacin i loko o nā lāʻau lapaʻau ma Rusia a me Ukraine:

ʻO ka hopena Avelox no ka infra intravenous 400 mg / 250 ml 1 pahu - 1137-1345 rubles, 600-1066 hryvnias,
ʻO ka hopena Moxifloxacin-Farmex no ka infusion intravenous 400 mg / 250 ml 1 ipu - 420-440 hryvnia,
ʻO ka hopena Maxicin no ka infra intravenous 400 mg / 250 ml 1 pākaha - 266-285 hryvnia,
ʻO nā papa Avelox 400 mg, 5 mau ʻāpana no ka pā - 729-861 rubles, 280-443 hryvnias,
Hoʻomoe ka maka o Vigamox i ka 0,5% 5 ml - 205-160 rubles, 69-120 hryvnias.

Lapaʻau lāʻau

ʻO Moxifloxacin ka lāʻau antimicrobial o ka hui fluoroquinolone, ka hopena i ka hopena bactericidal, ka hoʻokalakupua o nā mea no ka hoʻomakeʻa ʻana o nā enzymes topoisomerase II (DNA gyrase) a me topoisomerase IV, ka mea e pono ai no ka hoʻohuli ʻana, transkripsi a me ka hoʻoponopono ʻana i ka deoxyribonucleic acid (DNA), me ka make o ka hopena o ka make. pūloko.

Hoʻohālikelike ka nānā ʻana o ka maʻi bactericidal liʻiliʻi ma kahi mea i hoʻohiolo ʻia me ka liʻiliʻi o ka ʻohi ʻana mai i ka liʻiliʻi (MIC). ʻAʻole ka hoʻowalewale ʻia ka hana antibibial e nā mīkini e alakaʻi i ka hoʻomaka ʻana o ke kū'ē i nā macrolides, aminoglycosides, cephalosporins, penicillins a me tetracyclines. ʻAʻole i ʻike ʻia ke kūlia pale ma waena o kēia mau hui antibiotika a me moxifloxacin, ʻaʻole i ʻike ʻia nā hihia o ke kūpake plasmid. Ke kū mālie nei ka pale ʻana i ka mea hana ikaika ma o nā ʻano he nui. E kūʻē i ke kiʻi hou o nā hopena o ka lāʻau i ka microorganisms ma nā kikowaena ma lalo o ka MIC, ua ʻike wale ka nui iki o kēia hōʻailona.ʻIke ʻia ke kū'ē i nā quinolones, eia naʻe, kekahi mau micro-positive a me anaerobic microorganism e hōʻike i ka kūʻē i nā quinolones e hōʻike i ka naʻau o ka moxifloxacin.

Ua hōʻike ʻia nā haʻawina vitro i nā hana i kū i ka nui o ka anaerobes, nā gram-kino a me ka micro-positive microorganisms, nā atypical a me nā pale-kū i nā huakini, e like me Legionella spp., Chlamydia spp., Mycoplasma spp., A me nā mea kū'ē kū'ē i ka pale ʻole ka hana a ka maʻi o P-lactam a me nā maʻi maʻi macrolide.

I loko o nā haʻawina ʻelua i hana ʻia e pili ana i nā mea hana, e ukali ana i ka waha o ka waha o ka waiwai ikaika, ua ʻike ʻia nā loli like me ka microflora o ka ʻōpū. . ^ E Ha yM. a me Bifidobacterium spp. ʻO ka nui o kēia mau microorganism i hoʻi hou i loko o nā hebedoma ʻelua. ʻAʻole i ʻike ʻia nā mea momona o Clostridium.

Ma lalo aʻe nei i nā microorganism i loko o ka spra o nā hana antibacterial o moxifloxacin.

Hoʻopili nā nā pilikia o kēia microorganisms i hope no ka hana a ka lāʻau lapaʻau:

aerobes gram-negatif: Haemophilus influenzae a me Moraxella catarrhalis (me nā kaha o ka synthesizing a ʻaʻole synthesizing beta-lactamases) *, Haemophilus parainfluenzae *, Proteus vulgaris, Acinetobacter baumannii, Bordetella pertussis,
Aerobes Gram-positive: Gardnerella vaginalis, Streptococcus pneumoniae *, me nā mānoanoa me ka kūʻē o ka antibiotik a me nā palaka e hōʻike ana i ke kū'ē i ka penicillin, me nā māka e hōʻike ana i ke kūaloko o ʻelua a i ʻole nā mea maʻi, e like me penicillin (MIC ma mua o 2 2g / ml ), tetracyclines, cephalosporins generasi lua (e. g., cefuroxime), trimethoprim-sulfamethoxazole, macrolides, Streptococcus milleri (Streptococcus constellatus *, Streptococcus anginosus *, Streptococcus intermedius *), Streptocenes (a) Stoyptococcus)

Ke kūlike nei nā mana o nā microorganisms ma hope o ke ʻano o moxifloxacin:

aerobes gram-hewa: Enterobacter spp. . Providencia spp. (Providencia stuartii, Providencia rettgeri), Neisseria gonorrhoeae *,
aerobes gram-positive: Enterococcus faecium *, Enterococcus avium *, Enterococcus faecalis (ʻo nā hana ʻino wale nō i ka gentamicin a me ka vancomycin) *,
anaerobes: Clostridium spp. *, Peptostreptococcus spp. *, he mea make ʻo Bacteroides spp. (ʻO Bacteroides vulgaris *, ʻO Bacteroides fragilis *, ʻO Bacteroides thetaiotaomicron *, Bacteroides distasonis *, Bacteroides uniformis *, ʻO nā Bacteroides ovatus *).

ʻO kēia mau microorganism e kū'ē i ka lāʻau lapaʻau: coagulase-negative Staphylococcus spp. (ke kūpaʻa kūpaʻa methicillin-Staphylococcus cohnii, Staphylococcus haemolyticus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus hominis, Staphylococcus simureans)

* ʻO ka ʻike ʻana o nā microorganisms i moxifloxacin e hōʻoia ʻia e ka ʻikepili ʻike.

** ʻAʻole kōkua ʻia ka hoʻohana ʻana no ka mālama ʻana i nā maʻi i hoʻohuihui ʻia e nā mākaʻi me ke au o S. aureus (MRSA). Inā hoʻopaʻa ʻia a ʻeha paha nā maʻi ʻo MRSA, koi ʻia nā lāʻau lapaʻau kūpono e pono ai no ka mālama ʻana.

O ka mahele ana i ke kau ia ana o ka laea no kekahi kahiki e like paha me ka nui o ka manawa Ke hoʻāʻo nei i ka ʻike maʻi palupalu, ʻoi aku ia e loaʻa i ka ʻike kūloko kūloko, aʻo ia hoʻi he mea koʻikoʻi i ka loaʻa ʻana o nā maʻi ʻino.

ʻŌpū a me ka lactation

I ka wā hapai, ua hoʻohālikelike ʻia ka lāʻau moxifloxacin ma muli o ka nele o nā hōʻike lapaʻau e hōʻoia i kona palekana i kēia manawa. I loko o nā keiki e lawe nei i kekahi mau quinolones, ua hoʻopaʻa ʻia nā hihia o ka hoʻopili kino ʻana, akā ʻaʻohe mea i hōʻike ʻia o ka hanana ʻana o kēia maʻa ma ka pūpū i hoʻohana ʻia e ko lākou makuahine i ka wā hāpai. Ma nā noiʻi holoholona, ua ʻike ʻia nā huaʻawaʻi o ka hōʻawa o ka lāʻau, akā, ʻaʻole i hoʻokū ʻia kahi hiki i ke kanaka.

Mai ka liʻiliʻi o ka moxifloxacin e komo i ka waiū umauma, a ʻaʻohe data i ka hoʻohana ʻana i nā wahine hānai wahine, ua hoʻohana ʻia kona hoʻohana i ka wā o ka lactation.

Me ka hana pūpū hemahema

Ua hoʻohaumia ʻia ʻo Moxifloxacin no ka hoʻohana ʻana i nā hihia o ka papa C ate dysfunction e like me ka helu ʻana o nā keiki-Pugh, a me ke ʻano hoʻi o ka transaminase ma mua o elima mau manawa o ka VGN, ma muli o ka ʻike hoʻokolohua hoʻokaʻawale papaʻi. Ma mua o ka cirrhosis, ua contraindicated e hoʻohana i ka lāʻau lapaʻau a mālama pono paha e lawe ʻia (ma muli o ka mea hana).

I ka poʻe maʻi me nā maʻi hana o ka palaleka o nā papa A me ka B ma ke kiʻekiʻe Child-Pugh, ʻaʻohe mea pono e hoʻololi i ka regimen dos a moxifloxacin.

Hoʻohui nūhou

antidepresants tricyclic, hydroquinidine, quinidine, disopyramide (class IA antiarrhythmics), ibutilide, dofetilide, sotalol, amiodarone (papa III antiarrhythmics), halofantrine (antimalarials), pentamidine, erythromycin (me iv), sparflo ), sultopride, haloperidol, sertindole, pimozide, fenothiazine (antipsychotics), misolastine, astemizole, terfenadine (antihistamines), diphemanil, bepridil, vincamine (me ka hoʻomehana iv), cisapride a me nā lāʻau lapaʻau ʻē aʻe e pili ana i ka elongation a Tervala QT: lākou i hoʻohui pū ana me ka moxifloxacin ua contraindicated ma muli o ka aggravation o ka pilikia o ventricular arrhythmia (me ventricular tachycardia type torsade de Ka Pointe ..),
hoʻomākaukau e pili ana i ka hao, zinc, magnesium a me alumini, antacids, lāʻau antiretroviral (didanosine), sucralfate: kahi hoʻemi nui o ka neʻe o ka moxifloxacin hiki ke hanana ma muli o ka hoʻokumu ʻana o ka paʻakikī chelate me nā ʻōkuhi lehulehu me ka hoʻopili ʻana i kā lākou hui, ka wā ma waena o ka lawe ʻana i kēia mau lāʻau a me ka moxifloxacin e pono. paha ma kahi o 4 hola
carbon hoʻoneʻe: hoʻoneʻe ʻia ma ka pale ʻana i ka hoʻopili ʻana o ka antibiotic, hoʻemi ʻia kona bioavailability systemic e oi aku ma mua o 80% (i ka wa i lawe ʻia 400 400 mg),
digoxin: ʻaʻohe hoʻololi koʻikoʻi ma nā hiʻohiʻona pharmacokinetic,
warfarin: ʻaʻohe loli i ka manawa prothrombin a me nā mea ʻē aʻe o ke koikoi koko, eia naʻe, hiki ke hoʻonui ʻia i ka hana o nā lāʻau anticoagulant, nā mea pili i ka hanana me nā maʻi hopohopo, nā kūlana maʻamau a me nā makahiki o ka mea maʻi, pono e nānā i INR a, inā pono, e hoʻololi i ka nui o nā ʻano anticoagulants.
cyclosporine, supplementation calcium, atenolol, theophylline, ranitidine, oral contraceptives, itraconazole, glibenclamide, morphine, digoxin, probenecid - ʻaʻohe mau hui o ka nui o ke ʻano o kēia mau lāʻau me ka moxifloxacin i ʻike ʻia (ʻaʻole koi ʻia nā loli ʻaʻole).
ʻO ka hopena o ka sodium bicarbonate o 4.2 a me 8,4%, ka hopena o ka sodium klorida o ka 10 a me 20% - ʻaʻole kūpono kēia mau pane i ka hoʻonā infus moxifloxacin (i ka manawa like ʻaʻole i pāpā ʻia ia e komo).

Analogs o moxifloxacin i Vigamoks, Alvelon-MF Megafloks, Avelox, Moksigram, Maksifloks, Akvamoks, Moksistar, Moksiflo, Moksispenser, Moksimak, Moxifloxacin Sandoz, Moxifloxacin ChP Moxifloxacin Alvogen, Moflaksiya, Moxifloxacin STADA, Moxifloxacin Canon Moxifloxacin-Verein , Plevilox, Rotomox, Moxifur, Moxifloxacin-TL, Ultramox, Simoflox, Heinemox.