ʻO ka lāʻau Pentilin: nā ʻōlelo no ka hoʻohana ʻana

I loko, i ka wā a ma hope o ka ʻai ʻana, ka moni ʻana i ka holoʻokoʻa, 400 mg 2-3 mau manawa i ka lā, papa - ʻokoʻa ma 8 wiki.

In / i loko a i / i kahi inikini: 50-100 mg / lā (i ka paʻakai) no 5 mau minuke. In / a i loko a / i kahi infusion: 100-400 mg / lā (i ka paʻakai physiological), ka lōʻihi o ka infusion intravenous - 90-180 mau minuke, i / a - 10-30 mau minuke, ka nui o kēlā me kēia lā he nui o 800 a 1200 mg, ia manawa. ʻO ka infusion hoʻomau - 0.6 mg / kg / h no 24 mau hola, ʻoi loa ka nui o kēlā me kēia lā o 1200 mg.

Me Cl Clinine liʻiliʻi ma mua o 10 ml / min, ua hoʻemi ʻia ka nui o ka maʻi e 50-70%. No nā mea maʻi ma ka hemodialysis, hoʻomaka ka mālama ʻana i kahi maʻa o 400 mg / lā, e hoʻonui ʻia ana i ka maʻamau me ke aniani o ka liʻiliʻi i ka 4 lā.

E hoʻokuʻu i ke ʻano a me ka ʻano

• vahaolana no ka hoʻoponopono intravenous a intra-arterial: kūlike, ʻaʻole ʻoniʻoni a ʻulaʻula paha i ke kala (5 ml i ʻāpua, 5 mau ʻāpala i loko o kahi pālaʻi a i nā palaki paha, 1 blister a i ʻole pānaʻi i loko o ka pūlaki pepa).
• papa o ka hana hoʻomaloka, nā ʻoniʻoni kiʻi: oval, biconvex, keʻokeʻo (10 pcs. i loko o kahi palaha, i loko o ka pahu pahu pahu 2 blisters).

Ka hoʻonohonoho ʻana o 1 ampoule o ka hoʻoponopono ʻo Pentilin (5 ml):

• mea waiwai: pentoxifylline - 100 mg,
• Nā kumuhana hou: sodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate, sodium chloride, disodium edetate, wai no ka hōʻemi.

ʻO ka hoʻonohonoho ʻana o 1 papa Pentilin:

• mea waiwai: pentoxifylline - 400 mg,
• Nā kumuhana hou: magnesium stearate, hypromellose, macrogol 6000, silicon dioxide anhydrous colloidal,
• shell: hypromellose, macrogol 6000, talc, titanium dioxide E171.

Lapaʻau lāʻau

Pentoxifylline - ka waiwai ikaika o Pentilin - kahi antispasmodic mai ka hui purine e hoʻomaikaʻi i nā waiwai rheological (fluity) a me ka microcirculation koko. ʻO ka hoʻokūkū o ka hana o ka lāʻau lapaʻau ma muli o kona hiki ke hoʻēmi i ka phosphodiesterase a hoʻonui i ke kao o ka cyclic AMP i loko o nā platelets a me ka ATP i nā ʻāpana koko wīwī, ʻoiai e pīhoihoi ana i ka hiki ke ikehu, ma muli o ke ʻano o ka vasodilation, kūloko i ka pale ʻana o ka vascular kūloko peripheral, hōʻemi a piʻi ka nui o ka minamina o ke koko, ʻoiai ʻaʻole piʻi nui ka naʻau. ke hoʻohuli nei.

Hoʻomoe ka Pentoxifylline i ka lāʻau o ka coronary, e hoʻonui ana i ka lawe o ka oxygen i ka myocardium (antianginal effect), a me nā kīʻaha koko o nā pūpū, e hoʻomaikaʻi i ka oxygenation koko.

Hoʻonui ka lāʻau lapaʻau i ke kani o nā ʻōpū o ka hanu, ma nā kiko o ka diaphragm a me nā mea kūwaho intercostal.

Hoʻonui ia i ka microcirculation koko i nā wahi o ka laha o ka pōpilikia, hoʻonui i ka elasticity o ka memba erythrocyte, e hōʻemi i ka ike kuʻuna i ke koko.

Me ka lesi maʻamau o nā hālā peripheral (claudication clmittent), hoʻonui ka Pentilin i ka hele wāwae, hoʻoneʻe i nā pōkole pōkole o nā ʻeha ʻōiwi a me ke kaumaha i ka hoʻomaha.

Lapaʻau lāʻau

Hoʻomili nui ka Pentoxifylline i loko o nā ʻāpana koko ʻulaʻula a me ka puʻuwai. Ma hope o ka lawelawe waha, ua aneane loa ia mai ka gastrointestinal tract. ʻO ka lōʻihi o ke kau i nā papa i hāʻawi i kahi hoʻokuʻu mau o ka mea hoʻoikaika i ka lāʻau a me kona hoʻoiho ʻokoʻa.

Mālama ʻo Pentoxifylline i ka helehele ma waena o ka ate, ka hopena o nā metabolites hoʻonaninani ʻano nui: 1-3-carboxypropyl-3,7-dimethylxanthine (metabolite V) a me 1-5-hydroxyhexyl-3,7-dimethylxanthine (metabolite I), plasma ka ʻike i ka 8 a me 5 mau manawa i ʻoi aku ma mua o ka pentoxifylline, ma kēlā.

ʻAʻole paʻa ka Pentoxifylline a me nā metabolites i nā protein plasma.

Ke hōʻea nei ka lāʻau lapaʻau i ka palapala hoʻomohala i kona kiʻekiʻe loa i loko o 2 mau hola. E māhele ʻia wale ia. ʻO ka hapalua hapa-ola ʻo 0.5-1,5 hola.

ʻO ka hapalua o ka ola o ka pentoxifylline ma hope o kahi iniha intravenous o 100 mg ka mea ma kahi o 1,1 hola. Nui kona ʻike i ka hoʻoili ʻana (ma hope o ka hoʻoulu ʻana o 30 mau minuke o 200 mg - 168 L), a me kahi kikowaena kiʻekiʻe (4500-5100 ml / min).

ʻO ka 94% o ka loaʻa i lawe ʻia e hoʻopiʻi ʻia e nā keiki ma ke ʻano o nā metabolites (ʻoi loa ka metabolite V), ma kahi o 4% - e ka ʻōpū. I kēia hihia, a hiki i ka 90% o ka nui o ka wai i excreted i loko o nā 4 mau hola mua. Hoʻomoe ka hana a nā metabolites i nā mea maʻi me nā maʻi koʻikoʻi o ka maʻi. I ka hihia o nā hana heʻeha lēwa, e hoʻolōʻihi ʻia ka hapalua o ke ola o ka pentoxifylline a hoʻonui i kona bioavailability.

Lā ʻo Pentoxifylline i ka umauma umauma.

Nā hōʻailona no ka hoʻohana ʻana

• ka hoʻolohe ʻana ʻana i ka hopena o vascular,
• ka maʻi paʻa ʻana, subacute a me ka hoʻomaʻule hiki ʻole ke kaulike i ka retina a me ka choroid,
• ulia pōpilikia maʻi kūloko o ka ischemic kumu,
• hoʻāliʻi i ka endarteritis,
• maʻi huapuni holoʻokoʻa peripheral ma muli o ka atherosclerosis, maʻi mellitus (ʻ anglelo maʻi ngiopathy maʻi),
• kaʻōmaʻomaʻo (paresthesia, maʻi's Raynaud),
• nā maʻi līlio trophic ma muli o ka mea hoʻonani venous a microcirculation arterial (frostbite, post-thrombophlebitis syndrome, ulia trophic, gangrene),
• encircal a me atherosclerotic encephalopathies.

Nā Hoʻohui

• kahakaha cerebral,
• ʻūhū ʻia
• kahe koko nui
• ʻeha pūpū maʻamau
• nā hana maikaʻi loa,
• neʻe ʻole i ka ʻae o ka arterial hypotension,
• myocardial pili hewa
• nā hewa nui o ka atherosclerotic o ka coronary a i ʻole ka cerebral arteries,
• porphyria
• hapai, lactation,
• makahiki i 18 makahiki
• hypersensitivity o Pentilin ʻokoʻa a i ʻole methylxanthines.

• haehae
• nāwaliwali o ka puʻuwai
• hana 'āina i hana ai i ka hana (he hana i hana' ia ma lalo o 30 ml / min),
• lima hana hoʻopili hewa,
• hoʻonui hoʻonui ʻia i ka huhū, ke komo ʻana i ka wā e hoʻohana ana i nā anticoagulants, nā pilikia o ka ʻōnaehana koikoi koko, ma hope o ka hana ʻana i ka wā o ka hōʻiliʻili o ke kaʻa.
• ulia peptic o ka ʻōpū a me duodenum no nā papa.

ʻOka hoʻonā ʻana

Ma ke ʻano o kahi hoʻonā, ua lawelawe ʻia ʻo Pentilin ma intravenously a i ʻole intraarterially.

Ua hoʻoholo ke kauka i ke ala o ka hoʻokele a me ka hopena kūpono o ka lāʻau no kēlā me kēia maʻi, e pili ana i ka nui o nā pilikia o ke kaomi a me ka hoʻomanawanui ʻana o kēlā me kēia pentoxifylline. Hoʻokomo ʻia ka infusion intravenous i kahi kūlana supine.

Ma ke ʻano he laʻana, no ka mea maʻi maʻi maʻi, e mālama ʻia ka lāʻau lapaʻau i ka manawa 2 i ka lā (i ke kakahiaka a i ke ahiahi), 200 mg (2 ampoules o 5 ml i kēlā me kēia) a 300 mg (3 mau ʻāpana he 5 ml kēlā me kēia) i ka 250 a 500 ml o ka 0.9% hopena sodium klorida ? a? ole k? ka mea kani. Pono e hoʻohālikelike ʻia nā ʻōnaehana infusion ʻē aʻe akā maʻalahi e hoʻohana ʻia nā hopena kūlike.

ʻO ka lōʻihi o ka infusion ma kahi o 60 mau minuke no kahi kaʻe o ka pentoxifylline 100 mg. Hiki ke emi paha nā ʻōiwi i hōʻeha ʻia i mua o nā maʻi concomitant, no ka laʻana, ka huhū o ka naʻau. I ia mau hihia, he mea kūpono e hoʻohana i kahi infuser kūikawā e kāohi ai i ka hoʻopuʻi.

Ma hope o kahi infusion o kahi lā, inā pono, nā papa ʻaina Pentilin 400 mg i hoʻohui ʻia - 2 pcs. Inā hana ʻia nā infusions ʻelua i nā manawa lōʻihi, a laila hiki ke loaʻa iā 1 papa ma ke kakahiaka (ma kahi o 12 paha i ke ahiahi).

I nā hihia kahi e hoʻopili ʻia ai nā infusion intravenous ma muli o nā kūlana kulekele hoʻokahi wale nō i ka lā, hiki i ka lawelawe hoʻomohala hou o Pentilin i nā papa i loko o ka nui o nā 3 pcs. (2 papa i kaʻaina awakea, 1 i ke ahiahi).

I nā hihia koʻikoʻi, no ka laʻana, me ka gangrene, ulia trophic o ke kūlana III - IV e like me ka helu ʻana o Fontaine - Lerish - Pokrovsky, ʻeha hōʻeha i ka hoʻomaha, hoʻomāholo mau ka luna ʻana o ka lāʻau lapaʻau - no 24 mau hola.

Hōʻike ʻia nā kaha no ka hoʻokō intraarterial: i ka hoʻomaka o ka mālama ʻana - 100 mg o ka pentoxifylline i 50-100 ml o ka 0.9% sodium chloride solution, ma kēia lā aʻe - 100-400 mg i 50-100 ml o 0.9% hopena o ka sodium klorida. ʻO ka helu o ka hoʻokele he 10 mg / minuke, ʻo ka lōʻihi o ke kau ʻana he 10-30 mau minuke.

I ke ao, hiki iā ʻoe ke komo i ka lāʻau lapaʻau ma ka hopena a hiki i 1200 mg. I kēia hihia, hiki ke helu ʻia ke kūlike o ka mea maʻi e like me ka ʻōlelo aʻe: 0.6 mg o pentoxifylline i kg o ke kino o ke kino i kēlā me kēia hola. No laila, ʻo ka laʻana o kēlā me kēia lā e lilo ia 1000 mg no ka mea maʻi me ke koʻikoʻi o ke kino o 70 kg, 1150 mg no ka mea maʻi me ka paona kino o 80 kg.

ʻO nā maʻi me ka pilikia ʻole, e pili ana i ka hoʻomanawanui ʻana o ka lāʻau i ka lāʻau, hoʻoemi i ka nui ma o 30-50%.

Pono ka hōʻemi ʻia ʻana o ka maʻi ma nā maʻi me nā hana heʻeha luhi i hoʻopili ʻia, me ka hoʻohaʻahaʻa ʻia ʻo Pentilin e noʻonoʻo ʻia.

Manaʻo ʻia e hoʻomaka i ka mālama ʻana me nā haʻahaʻa haʻahaʻa me ka hoʻonui haʻahaʻa o nā mea maʻi me ka hoʻokahe koko haʻahaʻa, ʻo ia hoʻi i nā mea maʻi e hoʻemi ai i ke kahe koko (no ka laʻana me ka maʻi naʻau coronary koʻikoʻi, he stenosis koʻikoʻi nui o nā moku cerebral).

Pono e kiʻi aku i nā papa Pentilin 400 mg ma hope, ma hope o ka ʻai ʻana: ʻai pōʻai piha a inu nui ka wai.

ʻO ka ʻōlelo i ʻōlelo ʻia e 1 mau papa 2 a i ʻole 3 mau manawa ia i ka lā. Mai hoʻonui i kahi lā i kēlā me kēia lā o 1200 mg.

ʻO nā mea maʻi me ka hiki ʻole o ka hana renal failed (clearance clearance

Pākuʻi helu

400 papa papaʻa ʻoniʻoni

Aia ma ka papa papa

mea waiwai - 400000 pentoxify

nā mea hoʻowalewale: hypromellose, macrogol 6000, magnesium stearate, silicon dioxide colloidal anhydrous,

ukana moku: hypromellose, macrogol 6000, titanium dioxide (E 171), talc.

Nā papa hana oval i ka ʻōmaʻomaʻo biconvex, i kālai ʻia me ka uhi ʻulaʻula keʻokeʻo

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau

Ma hope o ka lawelawe waha, pentoxifylline e wikiwiki a holo i loko. ʻO ka bioavailability o nā papa pentoxifylline lōʻihi e pili ana i ka 20%. ʻAi ʻaʻai, akā ʻaʻole e hoʻemi i ka piha piha o ka lāʻau.

Loaʻa ka wela plasma nui i loko o 2 a 4 mau hola. ʻO ka Pentoxifylline e hoʻopuka i ka waiū umauma, ʻike ʻia i loko o nā hola 2 ma hope o ka hoʻokele ʻana, ma ʻelua - i loli a i ke ʻano o ka metabolites.

Piʻi ʻia ka Pentoxifylline i loko o ke akea a me ka liʻiliʻi i nā ʻāpana koko ʻulaʻula. Penei ka hōʻaia nui o nā kahe nui ʻana i ka maʻi ma ka hopena mua. ʻO 5 ka paʻila o nā metabolite ikaika e 5 a 8 mau manawa i luna ma mua o ka paʻa ʻana o ka pentoxifylline. Hoʻomiliʻia ia e ka uakiʻu (ma o ka α-keto reductase) a me ka oxidation.

ʻO nā Metabolites ke hoʻopiʻi nui ʻia ma ka urine (ma kahi o 95%). Ma kahi o 4% o ka nui i lawe ʻia ma ka feces. Ma kahi maʻi renal koʻikoʻi, hele lohi ka excretion o nā metabolites. Me ka maʻi hepatic, ua lōʻihi ka hapalua o ke ola a hoʻonui ka bioavailability. Ma kēia hana, i pale ai i ka hōʻemi ʻana o ka lāʻau i loko o ke kino o nā mea maʻi, e hoʻemi ʻia ka lāʻau.

Lapaʻau lāʻau

Hoʻonui ka Pentoxifylline i nā waiwai o ka rheological o ke koko ma o ka hoʻopiʻi ʻana i ka deformability pathologically i hoʻololi ʻia i nā ʻāpana koko wīwī, e hoʻoneʻe ana i ka hōʻuluʻulu ʻana o platelet a hoʻemi i ka nānā nui koko. Ka hana o ka hana o ka pentoxifylline e hoʻomaikaʻi i nā waiwai o ka rheological o ke koko me ka nui o ka nui o nā sela koko ʻōpala i nā pae o ATP (adenosine triphosphate), cAMP (cyclo-adenosine monophosphate) a me nā nīnūnika cyclic. ʻO ka pentoxifylline e hōʻemi nui i ka hikiʻole o ka plasma a me ke koko ma o ka hoʻemi ʻana i ka neʻe o ka fibrinogen. ʻO kēlā me ka emi o ka neʻe ʻana o ka fibrinogen ka hopena o ka hoʻonui i ka hana fibrinolytic a me ka hoʻohaʻahaʻa ʻana i kona synt synt. Eia kekahi, ma ka pale ʻana i nā membodi phosphodiesterase membrane (e alakaʻi ana i ka hoʻonui ʻana i ke kukū cAMP) a me ka pākuhi thromboxane, paʻa ka pentoxifylline i ka hōʻuluʻulu ʻana me ka hoʻonaninani a platelet a i ka manawa like, e hoʻoulu ai i ka synthesis o ka prostacyclin (prostaglandin I2).

ʻO ka pentoxifylline e hōʻemi i ka hana o interleukin ma monocytes a me nā macrophages, e hōʻemi ana i ka nui o ka hopena i hoʻopili ʻia. Māhuahua ka pentoxifylline i ke kahe o ke koko a peripheral a me ka cerebral, ka hoʻonui ʻana i ka kao e hilinaʻi nei i ka nui o ke kūpaʻa o ka oxygen i nā ʻeha o ka ischemic i hōʻalo ʻia i lalo o ka papale, ma ka cerebral cortex a me ka cerebrospinal fluid, ma ka papa retina o nā mea maʻi me ka retinopathy.

Nā hopena hopena

ʻO nā mea aʻe ka hopena i hōʻike ʻia i ka wā o ka hoʻokolohua ʻana i nā lāʻau lapaʻau a ma ka wā kūʻai aku.
Mai ka pūnaehana cardiovascular. ʻO Arrhythmia, tachycardia, angina pectoris, hoʻemi i ke koko, piʻi ke koko.
Mai ka papahana lymphatic a me ka ʻōnaehana koko. ʻO thrombocytopenia, thrombocytopenic purpura, aplastic anemia (ʻāpana hapa a hoʻopau paha i ka hoʻokumu ʻana o nā kelepona āpau), pancytopenia, hiki ke make.
Mai ka pūnaehana pili ʻana. ʻO ka ʻālana, ka ʻeha, ka meningitis aseptic, nā mea nui, paresthesias, nā kīwaha.
Mai ka gastrointestinal tract. Hōʻeha ka gastrointestinal, sensation o ke kahe i loko o ka ʻōpū, flatulence, nausea, luaʻi, a i ʻole ka ʻeha.
Ma ka ʻāpana o ka ʻili a me nā kiko kikoʻī. Itching, ʻulaʻulaʻula o ka ʻili a me ka urticaria, nā necrolysis epidermal a me nā maʻi Stevens-Johnson.
Hōʻino ka hana vascular. Ka wela o ka wela (nā uila wela), ke kahe, ke edema peripheral.
Mai ka pānaʻi. Anaphylactic hopena, hopena anaphylactoid, angioedema, bronchospasm a me ka hoʻihoʻi anaphylactic.
Ma ka ʻāpana o ka ate a me ka lolo. Intnahepatic cholestasis.
Nā maʻi noʻonoʻo ʻO kaʻili, haunaele hiamoe, hallucinations.
Mai ka ʻaoʻao o nā lālā o ka ʻike. Hōʻalo ka ʻike, conjunctivitis, hemorrhage retinal, detinalment retinal.
ʻO ka poʻe ʻē aʻe. Ua hōʻike ʻia nā kuʻuna o ka hypoglycemia, huhū nui, a me ke kuni.

Kahawai

ʻAʻole lawa ke ʻike me ka lāʻau lapaʻau Pentiline wahine hāpai. No laila, ʻaʻole kuhi ʻia e kuhikuhi i ka Pentilin i ka wā hāpai.
ʻO ka Pentoxifylline i kahi liʻiliʻi liʻiliʻi e komo i loko o ka waiū umauma. Inā kauoha ʻia ʻo Pentilin, e ho'ōki i ka hana ʻana i ka umauma.

Hoʻopili pū me nā lāʻau ʻē aʻe

Hiki ke hoʻonui ʻia ka hopena o ka hoʻohaʻahaʻa i ke kō koko koko i loko o ka insulin a i ʻole nā ​​ʻāpana antidiabetic waha. No laila, e nānā pono ʻia nā maʻi e loaʻa ana i ka lāʻau lapaʻau no ka maʻi diabetes.
I ka manawa o ke kūʻai aku, ua hōʻike ʻia nā hihia o ka hana anticoagulant i nā mea maʻi i mālama pū ʻia me ka pentoxifylline a me ka anti-vitamin K. Ke koho ʻia a loli paha ka manaʻo o ka pentoxifylline, ua ʻōlelo ʻia e nānā i ka hana anticoagulant i kēia hui o nā mea maʻi.
Pentiline e hoʻonui paha i ka hopena antihypertensive o nā lāʻau antihypertensive a me nā lāʻau lapaʻau ʻē aʻe, hiki iā ia ke hana i kahi hoʻohemo i ke koko.
ʻO ka hoʻohana like ʻana o ka pentoxifylline a me theophylline i kekahi mau mea maʻi hiki ke alakaʻi i ka hoʻonui i nā pae o theophylline i loko o ke koko. No laila, hiki iā ia ke hoʻonui i ke alapine a hoʻonui i nā hōʻike o nā hopena ʻino o ka theophylline.
Ketorolac, meloxicam.
ʻO ka hoʻohana like ʻana o ka pentoxifylline a me ke ketorolac hiki ke alakaʻi i ka hoʻonui i ka manawa prothrombin a hoʻonui i ka pilikia o ke kahe. Hiki ke hoʻonui aʻe i ka hōʻeha o ka kahe me ka hoʻohana ʻana i ka pentoxifylline a me ka meloxicam. No laila, ʻaʻole i kauoha ʻia ka hoʻomaʻamaʻa ʻana me kēia mau lāʻau.

Ke keu

ʻO nā hōʻailona mua o ka hala overdose Pentiline heʻano nausea, haki, tachycardia, a i ʻole hōʻemi i ke koko.Eia kekahi, ʻo nā hōʻailona e like me ke keokeo, ke kuʻuna, ka hoʻolalelale i ke wela (ka wela wela), ka nalowale o ka ʻike, isflexia, tonic-clonic seizures a me ka hiʻi ʻana o ka kala o ka wai kīwī e ulu pū kekahi me kahi hōʻailona o ke koko gastrointestinal.
Hoʻomaʻamaʻa. No ka mālama ʻana i ka overdose koʻikoʻi a pale aku i ka hōʻeha ʻana o nā hoʻopiʻi, ka ʻike ākea ākea a me ka nānā ʻana i nā ʻano lāʻau lapaʻau e pono ai.

Nā hiʻohiʻona noi

I nā hōʻailona mua o ka pane anaphylactic / anaphylactoid, pono e hoʻokaʻawale i ka mālama ʻana me ka pentoxifylline a ʻimi i ka ʻōlelo lapaʻau.

ʻO ka nānā kiaʻi lapaʻau nui pono e pono ai i nā poʻe maʻi me ka arrhythmias cardiac, hypotension arterial, coronary sclerosis, a me ka poʻe i loaʻa ka puʻuwai puʻuwai a i ʻole hōʻoki ʻana.

Ma ka hihia o ka pentoxifylline, ʻo nā mea maʻi me ka puʻuwai i hōʻemi ʻia e hele mua i ka mahele o ka uku koko.

No nā mea maʻi me ka systemus lupus erythematosus (SLE) a i ʻole i hoʻopili ʻia ai nā maʻi ʻupena, pentoxifylline hiki ke kuhikuhi wale ʻia ma hope o ka loiloi ʻana o nā hōʻeha kūpono a me nā pono.

Ma muli o ka hōʻeha o ka hemorrhage me ka hoʻohana pinepine ʻana o ka pentoxifylline a me nā anticoagulants waha, mālama pono a nānā pinepine ʻia o nā kiʻina koko coagulation (international normalized ratio (MES)) pono.

Ma muli o ka mea e pili ana i ka hoʻomohala ʻana i ka anemia aplastic i ka wā e mālama ai me ka pentoxifylline, pono e nānā pono ʻia ka helu ʻana o ka nui o ke koko.

I ka poʻe maʻi me ka maʻi maʻi a me ka loaʻa ʻana o ka mālama ʻana me ka inikini a i ʻole paha e hoʻohana ʻia nā ʻaila hypoglycemic waha, me ka hoʻohana ʻana i nā koina kiʻekiʻe nui o ka pentoxifylline, hiki ke hoʻonui i ka hopena o kēia mau lāʻau i ke kō koko koko (e ʻike i ka Māhele "Hoʻohālikelike me nā lāʻau lapaʻau a me nā ʻano like ʻole ʻē aʻe").

I nā mea maʻi me ka renal maikaʻi ʻole (ʻo ka hana ʻana ma lalo iho o 30 ml / min) a i ʻole nā ​​mea hōʻeha kino, pentoxifylline e hoʻopoki. Pono ʻia ka nānā ʻana.

ʻO nā maʻi me ka hala ʻole ʻole. I nā mea maʻi me ka maikaʻi ʻole (ʻoi aku ka hana ʻana o ka creatinine ma mua o 30 ml / min), ka hoʻomohala ʻana i nā dosis a hiki i ka 50-70% o ka maʻi maʻamau e hana i ka noʻonoʻo ʻana i kēlā me kēia pilikino, no ka laʻana, ka hoʻohana ʻana o pentoxifylline 400 mg 2 mau manawa i ka lā ma kahi o 400 mg 3 mau manawa i ka lā.

ʻO nā maʻi me ka puʻuwai koʻikoʻi. I loko o nā mea maʻi me ka pōpilikia o ka puʻuwai koʻikoʻi, pono ke hoʻoholo e hoʻemi i ka ʻona ma ke kauka, i ka ʻike ʻana i ka nui o ka maʻi a me ka hoʻomanawanui i kēlā me kēia kanaka hoʻomanawanui.

E nānā pono i ka nānā ʻana;

• nā mea maʻi me nā arrhythmias cardiac koʻikoʻi,
• nā mea maʻi me ka infococa myocardial
• nā mea maʻi me ka hypotension arterial,
• nā mea maʻi me ka atherosclerosis koʻikoʻi o nā moku cerebral a me ka coronary, keu me ka concomitant arterial hypertension a cardiac arrhythmias. I kēia mau mea maʻi, me ka hoʻohana pono ʻana i nā lāʻau lapaʻau, ka hoʻouka ʻana o ka angina, nā arrhythmias a me ka hypertension arterial.
• nā mea maʻi me ka maikaʻi ʻole (hoʻopili i hana ʻia ma lalo o 30 ml / min.),
• nā mea maʻi me ka maikaʻi ʻole o ka pūpū,
• nā mea maʻi me ka puʻuwai kiʻekiʻe i ke koko, ma muli, no ka laʻana, e ka mālama ʻana me anticoagulants a i ʻole nā ​​maʻi koko. No ka hoʻoheheʻe - e ʻike i nā ʻāpana "Contraindications",
• nā mea maʻi me ka mōʻaukala o nā ʻeha a me nā duodenal ulia, nā mea maʻi i hōʻaiho hou ʻia e ka hoʻomaʻemaʻe ʻana (me ka nui o ke kahe o ke koko, e koi ana i ka mālama pono ʻana o ka hemoglobin a me nā pae hematocrit)
• nā mea maʻi e hoʻomaʻamaʻa pū ʻia me nā pentoxifylline a me nā vitamin K antagonist (e ʻike i ka ʻāpana "Hoʻohui ʻana i nā lāʻau lapaʻau a me nā ʻano ʻano ʻē aʻe"),
• nā maʻi e loaʻa pū ana i ka mālama ʻia me nā pentoxifylline a me nā mea pena hypoglycemic (e nānā i ka ʻāpana "Hoʻohālikelike i nā ʻano lāʻau ʻē aʻe a me nā ʻano ʻē aʻe o kekahi ʻano.")

Hoʻohana i ka wā hāpai a me ka lactation

No ka mea ʻaʻole lawa ka ʻike me ka hoʻohana ʻana o ka pentoxifylline i nā wahine hāpai, ʻaʻole pono ke kuhikuhi ʻia i ka wā hāpai.

I ka wā lactation, hele ʻo pentoxifylline i loko o ka waiū umauma. Eia naʻe, loaʻa ka liʻiliʻi o ke keiki i nā liʻiliʻi liʻiliʻi. No laila, ʻaʻole hiki ke hoʻololi ʻia ka hoʻohana ʻana o ka pentoxifylline i ka wā o ka hoʻoulu ʻana i ka wai liʻiliʻi i ka pēpē.

ʻO ka hiki ke alakaʻi i ka hopena i ka wā e lawe ana i nā kaʻa a i ʻole nā ​​hana ʻē aʻe

ʻAʻole liʻiliʻi a ʻaʻohe hopena o Pentilin i ka hiki ke alakaʻi i kahi kaʻa a me nā mīkini ʻē aʻe. Eia nō naʻe, i kekahi mau mea maʻi hiki iā ia ke hōʻeha i ka dizziness, a no laila, ma ka hoʻihoʻi ʻole i ka hiki ʻana i ka psychophysical hiki ke hoʻokele i kaʻa a me nā mīkini like. A hiki i ka poʻe maʻi e ʻike pehea e pane ai lākou i ka mālama ʻana, ʻaʻohe mea e aʻo ʻia ai e halihali i ke kaʻa a i ʻole hana me nā mīkini ʻē aʻe.