ʻO nā paila mellitus maʻi

Hoʻokomo ʻia ka Therapy no ke ʻano type mellitus type 2 ʻaʻole wale ma ke ʻano kūikawā, akā ke kau nei hoʻi i ka waiwai o ka huahana synthet i kūpono no ka maʻi.

Pono lākou e hoʻokō pono i nā helu glycemia maʻamau.

I waena o nā ʻano lāʻau he nui i hāʻawi ʻia e ka mākeke lāʻau lapaʻau, kuhikuhi pinepine nā poʻe maʻi i nā papa Glibomet.

ʻO ka ʻike nui e pili ana i ka lāʻau lapaʻau, hoʻokuʻu i ke ʻano a me ka ʻano

ʻO Glibomet nā lālā o ka lāʻau hypoglycemic i lawe ʻia ma ke alo. Ke hana ʻia ka lāʻau lapaʻau e ka hui Kelemania ʻo BERLIN-CHEMIE / MENARINI. Ma kahi o Glibomet, ma Rūsia ma mua o 100 mau lāʻau lapaʻau o kēia ʻoihana, ua kākau inoa ʻia, ka mea i hoʻohana nui ʻia i ka mālama ʻana i nā maʻi he nui a ua hoʻokele ʻia ka loaʻa i ka hilinaʻi o nā maʻi.

Kele ʻia ka lāʻau lapaʻau i ke ʻano o nā papa i pani ʻia me ka ʻulaʻula keʻokeʻo. Loaʻa iā lākou āpau i 2 mau hiʻohiʻona ikaika a me nā huina o nā mea kōkua.

Aia ka papa o ka lāʻau lapaʻau:

• ʻO Glibenclamide (2.5 mg) a me Metformin Hydrochloride (400 mg) nā mea nui,
• pākaʻi palaoa (57) mg,
• cellulose (kanu polysaccharide) - 65 mg,
• silicon dioxide (ka meaʻai hoʻohui E551) - 20 mg,
• gelatin - 40 mg
• Glycerol - 17.5 mg,
• talc (mineral) - 15 mg,
• Diethyl phthalate (0.5 mg) a me 2 mg Acetylphthalyl cellulose - aia i loko o kaʻili o nā papa.

Hiki i ka pōkole ke 40, 60 a 100 mau papa.

Pharmacology a me ka pharmacokinetics

Mahalo i nā mea i loaʻa i loko o ka hoʻomākaukau, hōʻemi ka lāʻau lapaʻau i ka hōʻailona glucose i loko o ke koko o ka mea maʻi.

ʻO ka hana lāʻau lapaʻau o ka waiwai Glibenclamide:

• hoʻoikaika i ka ʻili o ka insulin, a hoʻonui pū i ka hoʻokuʻu i ka hormone,
• kōkua i ka hoʻonui ʻia ʻana o ka insulin i ke kino,
• hoʻonui i ka hopena o ka insulin ma ka glucose,
• hoʻololo i ke kaʻina o ke lipolysis.

Kūmole hana ia Metformin:

• kōkua i ka hoʻonui ʻana i ka hoʻonaninani ʻana i ka insulin, a hoʻomaikaʻi pū i kona hopena
• hoʻohaʻahaʻa i ke komo ʻana o nā glucose i loko o ka ʻōpū, hoʻomaikaʻi i kona komo ʻana e nā kino ʻē aʻe,
• kōkua i ka hoʻopaʻa ʻana i ka gluconeogenesis,
• pili pono i ka lipid metabolism, kahi e alakaʻi ai i ka paona.

Hiki ke hoʻokō i ka hōʻemi i ka glycemia ma hope o kahi pōpoki ma hope o 2 mau hola a mālama i nā hola 12.

Hoʻohālikelike ka hopena o ka lāʻau pharmacological o nā hiʻohiʻona e nā hiʻohiʻona o ka maʻa, ka hoʻowalewale, ka hoʻokūkū a me ka excretion o nā mea nui.

1. Ke kaʻina a me ka hoʻoili ʻana. ʻO ka piʻi lōʻihi loa o ka waihona hiki i ka mau hola 2 ma hope o ka hoʻokele ʻana. Hoʻololi koke ʻia ka māhele mai ka digestive tract (gastrointestinal tract). ʻO ka pilina o nā mea me nā protein plasma e loaʻa i ka 97%.
2. ʻO ka metabolabol ka hopena e kokoke loa i ka palupalu.
3. Leʻaleʻa. Hana ʻia nā hana hana e kēia mau keiki. Lawe ʻia ka ʻoihana a pau me ka ʻoi a me ka bile ma o ka urine. ʻO ka hapalua ola ke 10 hola.

1. ʻO ka hoʻopili ʻana a me ka wehe ʻana i nā ʻili o ka mea e neʻe koke a maʻalahi.
2. ʻO ka excretion o ka māhele mai ke kino e loli ma o nā ʻōpū a me nā puʻu. ʻO ka hoʻopau hapa hapalua-ola e 7 mau hola.

Nā hōʻailona a me nā contraindications no ke hoʻohana

Hoʻomaopopo ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana me ka maʻi diabetes type 2, i ka wā eʻai ai ka lāʻau a me nā lāʻau lapaʻau me nā lāʻau ʻē aʻe.

• hypersensitivity o kekahi o nā lāʻau o ka lāʻau,
• maʻi diabetes type 1
• maʻi maʻi maʻi gestational
• lactic acidosis,
• ketoacidosis
• coma (hypoglycemic a hyperglycemic),
• pilikia hanalei,
• palaki o ka mōʻī, nā pēpē,
• gangenne
• ka hele ʻana o nā maʻi nui,
• interventions opi, me ka hala nui o ke koko,
• nā ʻeha a hōʻā ʻia
• i kekahi kūlana e koi ana i ka hoʻohana ʻana i ka lāʻau o ka insulin,
• leukopenia
• porphyria
• nā loli dystrophic
• make wai make,
• umauma umauma,
• keiki, ʻōpio ma lalo o 18 makahiki.
• hapai

Nā ʻōkuhi no ka hoʻohana a me nā ʻōlelo aʻoaʻo kūikawā

Lawe ʻia nā papa ʻōlelo me ka ʻai. Pono e koho ʻia ka nui o ka lāʻau e ke kauka, i ka nānā ʻana i ke kaʻina o ka pakanā o nā kalapona a me ke glycemia i ka mea maʻi.

Hoʻomaka pinepine ka lāʻau lapaʻau i ka papa hoʻokahi. Aia ma muli o nā hopena o ka lapaʻau, ʻokoʻa paha ke ʻano. ʻO ka nui o nā papa i ʻae ʻia i kēlā me kēia lā he 6, no ka mea he pilikia ia e lawe iā lākou ma kahi kiʻekiʻe kiʻekiʻe. Hoʻoholo ʻia ka maikaʻi o ka regimen mālama i koho ʻia e ka waiwai glucose i loaʻa.

He mea nui ia i nā poʻe maʻi e pili i nā loiloi a ke kauka e pili ana i ka meaʻai, ke ʻano o ka hoʻokele ʻana a me ka nui o ka lāʻau. Me ka maʻi decompensated, ka pōloli, ka inu ʻawaʻawa, ka nui o ka hana o ka ʻōpū, a me nā mea hōʻike ʻē aʻe o ka hypoxia, pono e mālama ʻia nā papa me ka akahele ma muli o ka loaʻa ʻana o ka waʻawa lactic acidosis. ʻO kēia ke kumu o ka hōʻiliʻili o ka metformin, ma muli o ke kahi o ka lactate e ʻike i ke koko.

ʻO ka ʻaeʻana i nā kālā e pili ana i ka hana kauoha mai nā hoʻokaʻina koko no ka mea hana.

• Hoʻokahi makahiki i ka wā o ka hana maʻamau maʻamau (i nā maʻi me ka maʻi o ka maʻi maʻi),
• ʻoi aku ka nui ma mua o 2 mau manawa i kēlā me ka poʻe me HBV (congenital adrenal hyperplasia) a i nā maʻi maʻi maʻi.

• hoʻohana me ka diuretics me ka mālama
• mai lawe i ka lāʻau lapaʻau i ʻelua lā ma mua o ka hoʻokolokolo ʻana a X-ray a i ʻole ka hoʻokau ʻana me ka hoʻohana ʻana i ka anesthesia.
• hoʻomau hou i ka hana ma hope o 48 mau hola mai ka manawa o kahi paʻa ʻana ma lalo o ke ʻano o ka hana maʻamau o nā pēpē,
• mai lawe i ka wai inu me ka lāʻau lapaʻau i mea e pale ai i ka hypoglycemia a i ʻole ka hanana ʻana o nā ʻano ʻano like ʻole ma muli o ka inu ʻona.
• ʻO ka lāʻau lapaʻau e hōʻemi i ka helu o nā hopena psychomotor, hiki i ka mea ke hoʻopilikia i ka hoʻokele.

ʻO ka maʻi maʻamau ʻo mellitus kekahi o nā maʻi i loaʻa i ka mea maʻi. Ma mua o nā ala'ē aʻe, he mea nui ka lawe i ka lāʻau lapaʻau me ka mālama nui.

He hui kūikawā o nā maʻi:

• hāpai a ʻeha paha lactating makuahine (ua hoʻohālikelike ʻia ka lāʻau),
• nā mea maʻi me ka hana aho lēwa (e pāpā ʻia ka lāʻau lapaʻau no ka hoʻohana ʻana),
• nā kānaka me nā pilikia o ke keiki (me ka hana mai 135 mmol / l i nā kāne a ma luna o 100 mmol / l i loko o nā wahine, ua pāpā ʻia ka lāʻau lapaʻau).

ʻAʻole ʻōlelo ʻia ka lāʻau lapaʻau e hoʻohana ʻia e nā mea maʻi ma mua o 60 mau makahiki o kona mau makahiki, mai ka wā e hana ai i ka hana kino olakino hiki iā lākou ke hoʻomohala ma ka lactic acidosis.

Nā hopena ʻaoʻao a me ka overdose

ʻO ka lawe ʻana i ka lāʻau lapaʻau hiki ke kumu i ka hopena ʻino:

• e pili ana i ka hoʻowalewale ʻana - i ka hōʻeha ʻana o ka ʻuwaa a me ka luaʻi, lilo a pau ʻole i ka pau ʻana o ka momona, ʻeha ʻole ke kīwaha.
• mai nā kahe o ka hoʻopili - leukopenia, a me ka anemia a me nā pancytopenia,
• e pili ana i ka ʻōnaehana pīpilikia - headache,
• itching, urticaria, erythema,
• hypoglycemia aiʻole lactic acidosis,
• palpitations puʻuwai.

Me kahi overdose o ka lāʻau, hōʻino ka maikaʻi o ka mea maʻi i ka ulu ʻana, ulu ka hypoglycemia. I kēia hihia, pono ʻoe e ʻai i ka momona. ʻO ka holomua o hypoglycemia hiki i ka nalowale o ka pale pono ʻana a me ka ʻike. I kēia kūlana, ʻaʻole hiki i ka mea maʻi ke ʻai, no laila, e noi ʻia ka glucose me ka intravenous.

Hoʻopili pū kekahi me nā lāʻau lapaʻau a me nā hōʻailona

Hoʻohui ʻia ka hopena hypoglycemic o ka lāʻau ma lalo o ka mana o nā mea pena e like me:

• Derivatives dermarin,
• Kahiko,
• MAO ka mea paʻa
• hikouhaila
• Sulfonamides,
• ʻO Miconazole
• Feniramidol
• Ethanol

No ka hōʻemi ʻana i ka hopena o ka hoʻohana ʻana i ka lāʻau lapaʻau e pili ana i ka:

• Hakaakao,
• Thiazide kaiohiku,
• nā mea hoʻohālikelike (waha),
• nā hormones e hoʻomau i ka thyroid gland,
• ʻAhakaline.

Inā ʻaʻole i kūpono ʻo Glibomet no kekahi mau kumu, aia ka nui o nā mea hoʻohālikelike, ʻokoʻa i ka hoʻonohonoho ʻana a me nā kumukūʻai.

ʻO nā mea nui:

He mea nui ia e hoʻomaopopo he kauka wale nō e hana i kahi hoʻoholo e pili ana i ka loli ʻana o Glibomet me nā lāʻau ʻē aʻe.

He wikiō ma ke ʻano e hoʻemi ai i ke kō koko koko ma ka home:

ʻO nā manaʻo hoʻomanawanui a me nā kumukūʻai lāʻau lapaʻau

Mai nā loiloi o nā mea maʻi, hiki ke hoʻoholo ʻia e lālau ʻia ka lāʻau lapaʻau me ka akahele, no ka mea, ua nui ka hopena o ka ʻaoʻao, pono nō hoʻi e nīnau i kahi loea ma mua o ka lawe ʻana i ka lāʻau.

Ua hoʻomaka wau e lawe i ka lāʻau lapaʻau e like me ka mea i kuhikuhi ʻia e ke kauka. I ka lā mua o ke mālama ʻana, ua ʻelua ia i nā hōʻailona o ka hypoglycemia, ʻoiai ʻaʻole i loli kāna kīʻaha. ʻAʻole hiki iaʻu ke hele koke i ke kauka, no laila ua hoʻoholo pilikino au ʻaʻole e hoʻāʻo hou i ka hana hou ʻana a hoʻi i ka lawe ʻana i nā lāʻau o mua.

Ua ʻoluʻolu loa wau iā Glibomet. Me kona kōkua, hiki i ka hoʻokohala i ka pae o ke kō. Ma hope o ka heluhelu ʻana i nā ʻōkuhi, i ka manawa mua ua makaʻu ʻo ia i ka papa inoa nui o nā hopena ʻoli, akā hoʻoholo ia e hilinaʻi i ke kauka. Ua ʻoluʻolu ka hopena.

I ka makahiki i hala ua lawe wau i kēia mau pala. ʻAʻole kūpono kēia lāʻau lapaʻau iaʻu, no ka mea, ua kūlohelohe ka mea metallic i loko o koʻu waha i ka manawa a pau a i kekahi manawa he lago wau.

Nikita Alexandrovich, 65 makahiki

Hōʻemi ka mea momona i ke kō, akā i ka wā o kona komo ʻana, ʻaʻole hiki iā ʻoe ke hele i kahi kīmaki, ʻaʻole like me nā kīʻaha nui. Pono ke Glybomet i ka meaʻai maʻamau no ka mea ʻaʻohe hypoglycemia.

ʻO ke kumu o ka lāʻau lapaʻau e like me 350 rubles no 40 mau papa.

Glybomet - kaʻili

ʻO ka hui pū i kēlā me kēia papa o ka pūnaehana ikaika ʻelua - metformin hydrochloride (400 mg) a me glibenclamide (2.5 mg) hiki i ka hiki ke kāohi wale i ka glycemia, akā ke hōʻemi nei hoʻi i ka maʻi o kēia mau ʻāpana. Inā ua hoʻohana ʻia kēlā me kēia nona i ka monotherapy, e kiʻekiʻe loa ka nui o ka nui.

Loaʻa ia i ka pula a me nā mea loaʻa i ke ʻano o ka cellulose, starch mais, colloidal silicon dioxide, gelatin, glycerin, talc, magnesium stearate, acetylphthalyl cellulose, diethyl phthalate.

Nā hiʻohiʻona Pharmacological

ʻO kekahi o nā mea hana nui, ka glibenclamide, kahi lāʻau lapaʻau hou o ka papa o ka sulfonylurea, e waiho nei i ka papa inoa o nā mea ola nui me ka pancreatic a me nā mākau aku o ka pancreatic.

ʻAʻole ia e hoʻoulu wale i ka hana o ka pancreas holoʻokoʻa, akā e hoʻonui pū i ka hana o ka insulin endogenous. Kūkulu ka hana o kā lākou hana i ka pale o ka pancreatic β-cells i hoʻopau ʻia e ka glucose hoʻonāukiuki, e hoʻoholo ai i ka holo mua o ka maʻi diabetes, a me ka hoʻoulu ʻana i ka naʻau o ka insulin o nā cell target.

ʻO ka lawe ʻana i Glibomet i kahi kuʻikahi me ka mana glycemic e hoʻomaikaʻi i ka hana lipid metabolism a hoʻemi i ka hopena o nā koko koko. Hoʻonui ka hana o ka insulin, a me ia mea ʻo ka unuhi ʻana o ka glucose e nā io ʻoi a me nā ʻāʻī. Hoʻohana ka lāʻau lapaʻau i ka lua o ka hana o ka hana hana i ka insulin.

Aia ka Metformin no ka biguanides - kahi papa o nā mea hoʻonāukiuki e hōʻemi ana i ka insensitivity o nā selela makapō i kā lākou iho ponoʻī. ʻO ka hoʻihoʻi ʻana i ka naʻauao, ʻaʻole iʻoi aku ka mea nui ma mua o ka hoʻomaikaʻi ʻana i ka mea huna o ka hormone, no ka mea me ka maʻi diabetes type 2, hoʻohālikelike ka pancreas iā ia me ka keu.

Hoʻonui ka Metformin i ka pilina o nā mea paʻi a me ka insulin, hoʻonui i ka hoʻoponopono o ka postreceptor o ka hormone. I ka make ʻole o ka insulin i ka kahe koko, ʻaʻole i hōʻike ʻia ka hopena therapeutic.

Loaʻa i nā mea waiwai ka Metformin:

Ua nānā ʻia kahi hōʻike hoʻohālikelike o ka maʻi maʻi maʻi 5800 me ke ʻano maʻi type 2 i Kina. Ua loaʻa nā mea komo i ka hoʻokalakupua me ka metformin i hui pū me nā loli ʻano. I ka hui hoʻomalu, ua hoʻoponopono nā mea hana hou i ko lākou ola. No 63 mau mahina, ma ka hui mua, he 7.5 mau kānaka ma kahi o 1000 mau kānaka / mau makahiki, ma ka lua - no 45 mau mahina, e like me 11 nā kānaka.

Ma keʻano holoʻokoʻa, i ka hui e loaʻa ana i ka metformin, hoʻemi ka make ma ka 29.5% ma mua o ka kaohi, a me ka nui o nā hanana cardiovascular ʻoi ka 30-35%.

Hoʻomaka ka lāʻau lapaʻau e hana i ʻelua mau hola ma hope o ke komo ʻana i ka esophagus, ua hoʻolālā ʻia kona pono no nā hola 12. ʻAʻole hoʻokomo ʻo Metformin i kahi hoʻoweliweli hypoglycemic. ʻO ka lāʻau lapaʻau me kahi waihona hōʻike ʻoi nui, ua hala i kahi hōʻike paʻa mau o ka manawa a koi i ka maʻi maʻi i nā manawa a pau o ka hoʻonui ʻana i ka ʻoihana.

I kēia mau lā, hāʻawi ke kūʻai aku i ka lāʻau lapaʻau i nā papa he 10 o nā lāʻau antidiabetic, akāʻo ka metformin ka mea kaulana loa no ka mālama ʻana i ka maʻi type 2 i kēlā me kēia manawa o ka maʻi.

ʻO ka hui pūʻohu synergistic o nā mea hana ʻelua o Glibomet ka hopena paʻakikī i ke kino.

ʻO ka palena kiʻekiʻe o nā kikoo ikaika o nā mea ikaika e hiki ke hoʻoponopono nui i ka nui o ka lāʻau. No nā b-cell, he mea nui loa ka hoʻoulu ʻana o ka sparing: hoʻonui i ka palekana i ka lāʻau lapaʻau, hōʻemi i ka hōʻemi ʻana o ka hana hana, a hoʻemi i ka hopena o nā hopena like.

Hiki i nā maʻi Pharmacokinetic

Hoʻopili ʻia ʻo Glybenclamide mai ka gastrointestinal tract a hoʻoiho ʻia a hoʻokau maikaʻi loa ʻia - ma ka 84%, hiki ke nānā ʻia ka hopena nui o ka lāʻau lapaʻau ma hope o 1-2 mau hola. Hoʻopili ka māhele i nā ʻōnaehana koko ma 97%.

Hoʻolaha ka metabolible Glibenclamide i loko o ke akea, kahi e hoʻohuli ʻia i loko o nā mea i hana ʻole ai ka metabolites. ʻO ka hapalua o nā mea i hoʻopau ʻia e hele i nā ʻōpū, ʻo kekahi ʻaoʻao ma o nā kumu o ka bile. ʻO ka hapalua hapalua ke ola i nā hola 10.

Hoʻopau piha ka Metformin i ka ʻōnaehana kūwili, lawe koke ʻia i nā ʻāpana a me nā io, ʻaʻole paʻa i nā palekō i ke koko a pau. ʻO ka bioavailability o ka māhele mai 50-60%.

Ke kino, ʻaʻole aneane i hoʻohuli ai i loko o kona ʻano, i hoʻopili ʻia e nā ʻeha a me nā puʻu. ʻO ka hoʻopau hapa hapalua-ola he 10 hola.

Ka laulā maʻamau, ka lōʻihi o ka minamina o nā mea o ke ʻano o ke ʻano i loko o ke koko e loaʻa i hoʻokahi hola a i ʻole ʻelua ma hope o ka lawe ʻana i ka paila.

Nā hōʻailona no ka mālama ʻana me Glybomet

Ua hōʻike ʻia nā ʻōkuhi koʻikoʻi e kuhikuhi ʻia ka lāʻau lapaʻau no ka maʻi maʻamau o ka lā 2, me ka maʻi diabetes-hilinaʻi, inā he meaʻai kūikawā, ka hana kino dosed a me nā hopena hypoglycemic hāmama ʻaʻole i hāʻawi i ka hopena i hoʻolālā ʻia.

He nui nā hopena lapaʻau he nui inā pane ʻole ke kino i ka lāʻau lapaʻau, hoʻololi lākou i ka algorithm lapaʻau e ka kuhikuhi ʻana iā Glibomet i nā papa.

Pehea e lawe ai iā Glibomet

I ka hoʻoponopono ʻana e nā loiloi o ka endocrinologists, i mea e pale ai i ka acidosis lactic, maʻi maʻi ʻoihana ma mua o 60 mau makahiki o ka makahiki, me ka hoʻomaʻamaʻa kino ʻana i kēlā me kēia lā, pono ʻoe e lawe i ka lāʻau lapaʻau me ka akahele, hoʻopaʻa pinepine i ka glucometer ma loko o ka diary.

Aia mau kau palena i ka lawe ʻana iā Glibomet:

Hoʻoholo ʻia ka dosage e ka endocrinologist e like me nā makahiki a me nā mea maʻi a nā maʻi, akā ua hōʻike ka mea hana e hoʻomaka me ʻelua papa i kēlā me kēia lā, hopu mau i ka lāʻau. ʻO ka nui loa o ka lāʻau lapaʻau ka 2 g / lā. Hoʻomaopopo ʻia e ka hāʻawi ʻana i ka hoʻokipa i nā manawa maʻamau. Inā ʻaʻole i loaʻa kēia kālā i ka hopena i manaʻo ʻia, ʻōlelo ʻia ka hoʻomaʻemaʻe ʻana me ka hoʻohui ʻana i nā lāʻau ikaika ikaika.

Nā hopena ʻaoʻao a me ka overdose

He nui nā hopena kūpono ʻole e hiki mai ma hope o ka lawe ʻana iā Glibomet, akā ʻaʻole naʻe kēia kumu ke kumu o ka hōʻole ʻana i ka lāʻau lapaʻau, no ka mea ʻo ka hōʻeha ʻana i ke kino ʻaʻole i hoʻopiʻi i ka maʻi maʻi ʻoi aʻe ka kiʻekiʻe ma mua o ka hopena o ka hopena o ka hopena.

I mea e pale aku ai i kēlā mau kūlana, he mea nui e helu pololei i kāu maʻa. Inā overestimated ka maʻamau, hoʻāla ka maʻi diabetes i ka pōloli pōloli, ka nalowale o ka ikaika, ka huhū, lima nui.

Hiki ke ʻano o ka hōʻailona o ka overdose ke tachycardia, ke kīwaha ʻana o ka ʻili, hoʻonui nui ʻia, nāwaliwali.

ʻO nā hopena koʻikoʻi loa ma hope o ka lawe ʻana iā Glibomed, hypoglycemia e hōʻehaʻeha loa i kēia kūlana no nā poʻe maʻi e nawaliwali nei i kahi maʻi maʻi, maʻi diabetes, ʻo nā makahiki pākeke me nā maʻi lōʻihi, nā mea inu wai, ka poʻe i komo i ka hana kino paʻakikī, a me nā mea a pau e noho nei i ka hapalua nā ʻālunu. ua emi iho ma 1000 kcal / lā.) nā meaʻai.

ʻO nā hōʻailona maʻamau, ka mea maʻamau.

Inā hele mai kaʻoluʻolu pōkole o ka pōpilikia ma hope o ka lawe ʻana i nā papa, hiki ke hoʻopau ʻia e ka hōʻailona hōʻailona. Inā hōʻeha nā hōʻailona a hōʻailona ʻole nā ​​allergy, a laila pono ʻoe e koho i nā analogues no Glibomet.

Nā hopena hoʻopuka lāʻau lapaʻau

ʻO ka hoʻonui ʻana i ka hopena hypoglycemic o Glybomet i nānā ʻia i ka wā e pili ana i ka hopena me nā mea kikoʻī o ka decumarol, phenylbutamazone, β-blockers, oxytetracycline, allopurinol, cimetidine, ethanol, sulfinpyrazone i nā wai nui, probenecid, chloramphenicol, ka wai lāʻau nui, ʻaihola, . ^ E Ha yM.

ʻO ka hui hoʻohui me nā hormones no ka thyroid gland, oral contraceptives, barbiturates, thiazide diuretic drug pale i ka hiki o Glibomet.

I ka huli ʻana, e lilo i nā mea hana a Glibomet i mea e hoʻomehana ai no ka anticoagulants.

Nā ʻōlelo kikoʻī

Hoʻomaʻamaʻa koke ka hoʻohana ʻana o Glibomet i ka wā e loaʻa ai nā hōʻailona o ka acidosis lactic: nāwaliwali koʻikoʻi, luaʻi a me ka hōʻeha, ka naʻau o ka ʻeha o ka ʻōpū. Pono ka mea i hili i ka hoʻokaho.

Kauka ke aʻo i ka mālama ʻana me Glybomet e hele pū me ka nānā ʻana o ka creatinine i nā hōʻike koko. No nā mea maʻi me nā pēpē olakino, pono ia mea e pono ai ka hoʻokolohua i hoʻokahi manawa i hoʻokahi makahiki, nā poʻe maʻi e ʻike kokoke ana ka nui o ka creatinine i ka palena palena kiʻekiʻe o ka maʻamau, a pono e hoʻāʻo ʻia nā maʻi maʻi ʻo 2 mau manawa i ka makahiki.

ʻElua mau lā ma mua o ka hoʻolālā ʻana o ka hoʻomaʻamaʻa ʻana, kahi ke hoʻohana nei i ka anesthesia spinal a epidural paha, e lawe ana i Glibomet a kāpae ʻia a hoʻololi ʻia ka maʻi maʻi i ka insulin . ^ E Ha yM. Hiki iā ʻoe ke hoʻihoʻi i ka papa o ka mālama ʻana me Glybomet ma hope o ka ʻae ʻana i ka mea maʻi i nā meaʻai kūpono. ʻOiai me nā pēpē maʻamau e hana ai, ke hoʻoholo nei ke kauka i kēia hoʻoholo ma mua o ʻelua mau lā ma hope o ka hana.

Pono ka mālama ʻana i nā paila e mālama ʻia i ka wā e hoʻokau nei i nā hana i hiki i ke ola i ke ola a me ke olakino, like pū me ke kaʻa ʻana i nā kaʻa. Hoʻopili kēia i ka pilikia o ka hypoglycemia, kahi emi o ka hopena o ka hopena psychomotor a me ka hiki ke hoʻoikaika.

ʻO nā hopena o ka mālama ʻana me Glybomet e hilinaʻi nui i ka pololei o ka hoʻokō ʻana i nā ʻōlelo aʻoaʻo i ʻōlelo ʻia i nā ʻōlelo a me nā ʻōkuhi o ka endocrinologist: ka meaʻai a me ka hiamoe a me ka hoʻomaha ʻana, ka hana kino pilikino, ka mana o ka glycemic systematic, me ka home.

Ke hoʻohana ʻana i ka lāʻau lapaʻau, pono e hoʻokaʻawale i ka hoʻohana ʻana i ka wai ʻona ma mua o ka nui (ʻo ke ʻano he aniani o ka ʻulaʻula maloʻo hoʻokahi i ka hebedoma), no ka mea, e hoʻonāukiuki ana ka eʻai ʻana i ka hoʻomohala ʻana i ka glycemia, a me nā maʻi like ʻole a disulfiram - ʻeha i ka ʻāpaʻā epigastric, nā maʻi dyspeptic, pākaha wela i loko o ke kino ma luna a me ke poʻo, pau. coordination, headache, palpitations.

I loko o kahi pilikia o ka hakahaka o kahi renalous, ua hoʻohālikelike ʻia ʻo Glybomet i ka wā i ka hoʻokalakupua ʻana ʻo KK ʻoi aku ka nui ma mua o 135 mmol / l, inā he maʻi kāne ka mea maʻi, a ma luna o 110 mmol / l, inā he wahine ka maʻi maʻi.

He kumukūʻai o nā lāʻau lapaʻau a me nā lula mālama

Loaʻa iā Glybomet ma ke kaulahao kūʻai? Wahi a ka moku'āina, hiki ke kūʻai ʻia ka lāʻau lapaʻau no 200-350 rubles. ʻO kēlā me kēia pūʻulu o Glibomet, ke kiʻi o ke kiʻi e ʻike ʻia ma kēia ʻāpana, aia iā 40 papa.
No ka nalowale ʻana o ka lāʻau lapaʻau ka hana pono ʻana, pono ia e pale ʻia mai ka lā pololei a me ka haʻahaʻa kiʻekiʻe.

Nā lāʻau like ʻole

Inā ʻo Glibomed ma loko o ka loaʻa ʻana o ka pela paʻakai, ʻaʻole ia e hāʻawi i ka hopena i makemake ʻia, he allergy a i ʻole nā ​​hopena koʻikoʻi koʻikoʻi, ua hoʻololi ʻia ka lāʻau lapaʻau me nā mea hoʻomehana me kahi mea kūpono kūpono.

No Glibomed, hiki i nā lāʻau lapaʻau ke kau i nā papa Diabeton, nā mea hoʻomohala nui i ka glyclazide, a i Dimaril paha, aia ka ʻano hana like me nā mea like o Glibomed, glimepiride.

ʻO nā lāʻau lapaʻau antidiabetic e like me ka hopena like, ʻo Gluconorm, Bagomet Plus, Glucovans, Glibenclamide i hui pū me Metformin, ua kauoha ʻia ʻo Glyukofast.
ʻO ka poʻe endocrinologist kahi mea e hoʻololi ai, nāna nō e helu i ka dosage. Hiki ke loli ka hoʻoponopono ʻia ʻana: ʻoi aku ke ʻano o nā analogues ma ke ʻano paʻakikī a me ke ʻano o ka monotherapy, ma ka hoʻohui i ka ʻai haʻahaʻa a me ka hana kino.

ʻAʻole hiki i 100% hiki ke wānana i ka hopena o ke kino i nā lāʻau hou, no laila ua pono ka manawa mua hoʻolohe i nā ʻōmole a pau a haʻi i ke kauka e pili ana i ka loli wikiwiki ʻana i ke kaumaha, anu malaise ākea, nā hopena o ka hōʻike glycemia me kahi glucometer a me nā mea ʻē aʻe i ka manawa o ka hoʻololi ʻana i nā ʻano kumu ʻē aʻe o nā hanana.

Palapala Latin: ʻO Glibomet
ʻĀkau ATX: A10B D02
Mea waiwai: ʻO Glibenclamide
a me ka metformin hydrochloride
Mea Hana: Berlin Chemie, Kelemānia
ʻO nā lā hoʻomaha mai ka mea lapaʻau: Ma ke kumu
Wahi mālama: i ke 25 C
Ka lā hiki: 3 mau makahiki

ʻO Glibomet e pili ana i ka lāʻau lapaʻau hypoglycemic, i kuhikuhi ʻia no ka mellitus type II.

Hōʻike ʻia ka lāʻau lapaʻau Glibomet i ka hihia o ka maʻi maʻamau ʻo ka maʻi (ʻaʻole pono ka inika), i ka wā ʻaʻole i hoʻohana maikaʻi ʻia ka lāʻau lapaʻau me ka hoʻohana like ʻana o biguanides a i ʻole ka maikaʻi o ka sulfonylurea.

Nā hoʻonohonoho hoʻonohonoho a hoʻokuʻu i nā palapala

ʻO ka pūnaehana o ka papa Glibomet ka ʻelua o nā hana ikaika, ʻo ia hoʻi o ka glibenclamide, a me ka metformin hydrochloride, ka nui o ka hapa o kēia mau mea he 2.5 mg a me 400 mg, kēlā me kēia. Hoʻohui hou ʻia:

• ʻO Glycerol dibehenate
• ʻO Povidone
• ʻO ke kinikini silica colloidal
• ʻO ka lāʻau ʻo Magnesium
• ʻO ka sodium Croscarmellose
• Macrogol.

Ua puni nā papa, a waiū kekona, aia ka pilikia ma kekahi ʻaoʻao. Hoʻokomo ʻia nā papa i loko o kahi pūʻulu blister o 20 mau p., I loko o kahi pūʻulu o 2 mau palaka.

Hoʻomaopopo i nā waiwai

No ka Glibomet ka helu o ka lāʻau hypoglycemic me ka hui pū ʻana, ʻo nā mea ikaika e pili ana i ka sulfonylurea, a me ka lua o ka hanauna biguanide. Hoʻokomo ka lāʻau lapaʻau i ka hoʻohuihuiʻana o ka insulin i ka pancreas ma muli o ka hoʻohaʻahaʻa i ka paepae o ka hoʻonāukiuki β-cell e ka glucose pono'ī. Māhuahua ka hoʻonui i ka mea hiki i ka insulin, ʻoiai e hoʻopili ana i nā pūpū pili i hoʻonui ʻia, a hoʻomaikaʻi ʻia ka insulin. I ka wā o ka lāʻau antidiabetic, hana ʻia ke kaʻina o ke kūpaʻa o ka glucose e nā pupu a me nā mākau a me nā mākala, e pale aku i ka lipolysis e loaʻa ana i nā pā adipose. Kuhi ʻia ka glibenclamide ua hoʻopaʻa ʻia i ka lua o ka hana o ka huna ʻana o ka insulin.

He lālā ʻo Metformin i ka hui ʻo Biguanide. He hopena hoʻonāukiuki ia e pili ana i ka hoʻihoʻi ʻana o ka io i nā insulin, e hoʻolohi i ka hoʻōla o ka hoʻoliʻi glucose ma loko o ka ʻōpū, pale i ka gluconeogenesis, a hoʻopilikia pū kekahi i ka papa o lipid metabolism. E kue i kahi o kēia hopena kiko'ī, hiki i ka wikiwiki ke hōʻemi i ka nui o ke kino i ke kanaka e maʻi nei i ka maʻi maʻi.

Ka hopena hypoglycemic o ka hua'ōlelo Glibomet i hoʻopaʻa ʻia 2 mau hola ma hope o ke manawa o ka lawe ʻana i nā papa a ua mālama nā hola 12 aʻe. Ma muli o ka hui pū ʻana o nā mea hana ʻelua, hana ʻia ke kāpili o ka mea i kapa ʻia ʻo ka endogenous insulin, ka hopena nui o ka biguanide ʻaʻole wale ma luna o ka ʻiʻo a me ka iwi adipose, akā, ma ka ʻōpū o ka iwi (ma muli o ka emi o ka gluconeogenesis). Ma kēia hihia, ʻaʻole i hoʻopaʻa ʻia ka hoʻonāukiuki ikaika o ka cell-cell o ka pancreas, kahi e hōʻemi ana i nā kino o nā pathologies organ a me ka hoʻomohala ʻana i nā hōʻailona ʻelua.

ʻO ka pae o ka hoʻopaʻa ʻana o ka glibenclamide e ka mucosa gastrointestinal e pili ana i ka 84%. ʻO ka helu kiʻekiʻe o kēia mea i ke koko i hoʻopaʻa ʻia ma loko o 1-2 mau hola ma hope o ka hoʻohana ʻana i nā lāʻau. Ke kamaʻilio pū ʻana me nā protein plasma - 97%. ʻO ka hoʻololi ʻana o ka metabola o kēia māhele i loko o nā wahī o ke akeʻa; Ma ke kaʻina hana o nā huahana metabolic, ua komo ka gastrointestinal tract a me ka ʻōnaehana renal. ʻO ka hoʻopauʻana hapa hapalua-maʻamau maʻamau ʻaʻole iʻoi aku ma mua o 5-10 mau hola.

ʻO ke kumu o ka hoʻopili ʻana o ka metformin e ka mucosa gastrointestinal he kiʻekiʻe. Ke komo nei ia i ka ʻōnaehana o ka ʻōnaehana, ua ʻike ʻia kona wikiwiki ʻana i nā kao i loko, ʻaʻole hoʻi ia i komo i kahi pilina me nā protein plasma. Hoʻopili ʻia kēia ʻano mea i hōʻiliʻili ʻia, hoʻopili ʻia e nā ʻōnaehana renal a me nā mea ʻole. ʻO ka hapalua hapalua o ke metformin he 7 mau hola.

Glibomet: nā ʻōkuhi piha no ka hoʻohana

ʻO ka lāʻau i manaʻo ʻia no ka hoʻoponopono waha. Lawe iā Glybomet me nā meaʻai. Koho ʻia ka nui o ka maʻi me ka hoʻihoʻi ʻana i ka mālama ʻia e mālama i nā hōʻailona hōʻike i loaʻa, ka nui o ke kūpaʻa o ka glucose i ke koko, a me ke ʻano holoʻokoʻa o ka metabolism o ka paʻakai.

Hoʻomaʻama pinepine, ʻo ka papa ʻai kumu mua o ka lāʻau Glibomet ka 1-3 papa. Ke hele nei i ka wā antidiabetic therapy, ke koho pono ʻia ka hopena kūpono loa, e hoʻemi ana i ke kiʻekiʻe o ka glucose i nā kumu maʻamau. He mea kūpono ia e nānā i ke kiʻekiʻe o kēlā me kēia lā o ka lāʻau lapaʻau he 6 papa.

Nā Kūlana a me nā Mākaʻi

• Hoʻopilikia nui loa ia i nā mea kumu a me nā mea hou aʻe
• Insell-dependence diabetes mellitus (ʻano mua)
• E noho ma kahi piko maʻi a precoma paha
• ʻO ka hypoglycemia koʻikoʻi
• Ketoacidosis
• ʻO ka paleʻana o ka ate a me ka ʻōnaehana renal
• Kekoa, GV
• Lactic acidosis.

Pono ʻoe e hoʻopau koke i ka mālama ʻo Glibomet me nā hōʻailona mua o ka acidact lactic acid (ke ʻano o ke ahonui no ka maʻi, ka ʻeha o ka epigastric, ʻo ka lethargy, e paipai i ka luaʻi) a ʻimi aku i ka ʻōlelo a kāu kauka.

I ka wā o ka lāʻau antidiabetic, pono e mālama i ka mea hana i loko o ke koko: i ka waihoʻole ʻana o nā pathologies kidney - 1 p. i loko o ka makahiki, me ka hoʻonui ʻia o ka indexine a me nā mea maʻi kahiko - 2-4 p. no 12 mahina

Pono e hoʻopau ʻia nā lāʻau lapaʻau ma mua o nā hola 48 ma mua o ka hana hoʻohālikelike ʻia me nā anesthesia. Hiki iā ʻoe ke hoʻomau i ka papa ma hope o ka hoʻihoʻi piha ʻana o ka kīʻai maʻamau, akā ʻaʻole ia ma mua o 48 mau hola ma hope o ka hana me ka hōʻoia o ka hana piha o nā kau.

I ka wā o ka lāʻau antidiabetic, pono e mālama pono i ka mālama ʻana i ka wā e hana me nā hana kūpono a me ka hoʻokele ʻana, ʻoiai no ka maʻi hypoglycemia, hiki ke loli nui ka ʻike ʻana a me ka hopena psychomotor.

E hana ʻia ka hopena o ka ʻoihana e pili ana i nā ʻōlelo aʻo a ke kauka e pili ana i ka nui o ka make, ka mālama ʻana, ka hoʻoikaika kino a me ka nānā ʻana i nā glucose.

Pono e hoʻokaʻawale i ka mea inu pia, no ka mea aia he nui ke koʻikoʻi o ka hypoglycemia a i ʻole he hopena disulfiram-like ʻole.

Nā pili kūleʻa lāʻau

Hiki ke hoʻonui nui ʻia ka hopena hypoglycemic o ka lāʻau me ka hoʻohana pinepine ʻana o ka β-blockers, nā huaʻai o ka mea like me ka Coumarin a me ka phenylbutazone, me ka pale o MAO, salicylates, miconazole, cimetidine, sulfanilamides a me sulfonamides, oxytetracycline, probenecid, pheniramidol, a me ka perhexiline.

ʻO nā COC, nā lāʻau lapaʻau e pili ana i nā hormone thyroid, adrenaline, corticosteroids, diuretics o ka hui thiazide me nā barbiturates e hōʻemi ana i ka hopena hypoglycemic o Glibomet.

Me ka hoʻohana pū ʻana o anticoagulants, hiki ke nānā ʻia ka nui o kā lākou hopena.

ʻOiai e lawe ana i ka cimetidine, hiki i ka nui o ka hiki ke loaʻa ka lactic acidosis.

Ke lawe nei i β-blockers, hiki i nā hōʻailona akahū o ka hypoglycemia.

Ke hoʻohana nei i nā ʻaina radiopaque iodine, nui ka hopena o ka hana ʻōnaehana o ka ʻōnaehana, a me ka cumulation o ke ʻano ikaika lua o ka lāʻau - metformin, kahi e hiki ai ke hoʻonāukiuki i ka acidact lactic.

Nā hopena ʻaoʻao a me ka overdose

Hiki i ka poʻe lawe i kēia lāʻau lapaʻau ke ʻike i nā hanana ʻino he nui.

• ʻO ka maʻi Gastrointestinal: ke kala hōʻeha nui me ka makemake i ka luaʻi, pau ka momona, ka ʻeha o ka epigastric, ka ʻeha, ka hoʻāʻo ʻia i ka metalic kūloko i ka lua o ka waha, ʻokoʻa loa - hoʻonui i ka hana o ka transaminases
• ʻO ka ʻōnaehana hematopoietic: ka loaʻa ʻana o ka thrombocytopenia, leukopenia, a me ka erythrocytopenia, loaʻa pinepine paha - anemia (megaloblastic a i ʻole hemolytic ʻano), pancytopenia, agranulocytosis
• CNS: mau poʻo poʻohiwi pinepine
• ʻIli: ka umauma urticaria, pruritus, erythema, nā hōʻailona photosensitivity
• Metabolism: ka uluʻana o ka hypokalemia, i kekahi mau hihia - acidosis lactic.

Inā pono, hiki i ke kauka ke koho i nā analogues no ka lāʻau lapaʻau Glybomet (no ka laʻana, Diabeton). ʻO ka mea e kūpono ai ka Glibomet a i ʻole Diabeton, kūpono ia e nānā me kāu kauka.

ʻOi paha ka hoʻomohala ʻana o ka acidosis lactic (hoʻonāukiuki e ka ʻike ʻana i ka metformin) a me hypoglycemia (me ka glibenclamide).

Therapeutic therapy: me nā hōʻailona o ka lactic acidosis, pono ʻoe e hoʻopau koke i nā lāʻau lapaʻau a ʻimi i ke kōkua olakino. I kēia hihia, ua manaʻo ʻia ʻo ka hemodialysis he ala maikaʻi e pale ai i nā hōʻailona o ka maʻi.

Inā pilikia ka mea maʻi ma ka naʻaupō, a laila ke hoʻopau ʻia kahi kūleʻa o ka 40% dextrose i loko o kahi vein (ʻoi aku ka nui o ka nui o ka 80 ml), a laila pono kahi kuono o ka dextrose 10%. Ma muli o ke ʻano maʻi e pili ana i ka hoʻokele ʻana o ka glucagan (1 ml). Inā, ma hope o ka hana hoʻokō ʻia, hoʻomau ka hoʻomanawanui, ʻike hou ʻia nā hana i wehewehe ʻia. I ka loaʻa ʻole o kahi hopena therapeutic, e hoʻolālā ʻia kahi papa hana mālama maʻi maʻi.

Labourie Labourie, Farani

Kūʻai mai 269 a 366 rubles.

Diabeton - kahi lāʻau lapaʻau i hōʻike ʻia e ka hopena hypoglycemic haʻi. Ua hoʻonohonoho ʻia no ka mellitus type type 2 i mea e hoʻoponopono ai i ka synthesis o ka insulin. ʻO nā mea ikaika i ka maʻi Diabeton he gliclazide. Loaʻa i nā palapala papa.

• He kumu kūpono
• Hoʻopuka ʻia i ka pohō kaumaha
• Hoʻemi i ka loaʻa o ka hoʻopiʻi o ka maʻi diabetes.

• ʻAʻole i kuhikuhi ʻia i ka wā hāpai
• I ka wā o ka hoʻokele ʻana, hiki i nā pilikia gastrointestinal
• ʻAʻole kūpono no nā mea āpau.

Hoʻopili hope e ka mea hana 18.07.2005

Ka hana lāʻau lapaʻau

ʻO Glibenclamide - hoʻoulu ia i ka ʻōlelo huna o ka insulin ma ka hoʻohaʻahaʻa ʻana i ka paepae beta-cell glucose pancreatic, hoʻonui i ka naʻau o ka insulin a me kona paʻa ʻana i nā hua i hoʻopaʻa ʻia, hoʻonui i ka hoʻokuʻu ʻana i ka insulin, e hoʻonui ana i ka hopena o ka insulin ma ka ʻāʻī a me ka puʻu o ka ea glucose, a pale i ka lipolysis ma ka adipose tissue. Nā hana i ka lua o ka hana ʻana o ka inikini insulin.
Metformin - ke pale aku i ka gluconeogenesis i loko o ka kō, e hoʻoneʻe i ka kao ʻana o ka glucose mai ka gastrointestinal tract a hoʻonui i kona hoʻohana i nā kōna, hoʻoemi ʻia nā ʻike o ka triglycerides a me ka kolamu ma ka serum o ke koko. Hoʻonui i ka paʻa o ka insulin i nā receptors (i ka ʻike ʻole o ka insulin i loko o ke koko, ʻaʻole i hōʻike ʻia ka hopena therapeutic). ʻAʻole ia e kumu i ka pane hypoglycemic.

Lapaʻau lāʻau

ʻO Glibenclamide ka wikiwiki a kūpono i ka pae (84%) i hoʻopili ʻia ma ka ʻāpana o ka huina. ʻO ka manawa e hiki ai i nā hola C max - 7-8. Hoʻakeʻa i nā protein plasma - 97%. Ua aneaneʻokoʻa loa i loko o ke kaohi i ka hana neʻe o nā metabolites. Hoʻokuʻu ʻia ka 50% nā keiki a me 50% me ka bile. T 1/2 - 10-16 h.
ʻO ka Metformin ma hope o ka lawe ʻana i ka hana o ka kūwili (kūwaho - 48-52%) i hoʻopā ʻia e nā ʻōpū (ʻoi nui ka loli), i ka ʻāpana o nā ʻāpana. T 1/2 - 9-12 h.

ʻ a me ke kākele

I loko oiai e ai ana. Hoʻonohonoho ʻia ka dosage i kēlā me kēia, ʻokoʻa i ke ʻano o ka mea kāohi a me ke kō koko. ʻO ka pinepine, ʻo ka papa kaukau ma ka 1-3 papa. i kēlā me kēia lā me kahi koho lohi o ka make a hiki i kahi uku paʻa o nā maʻi. ʻO ka mea maikaʻi loa ke lawe nei i ka lāʻau lapaʻau 2 mau manawa i kahi lā (ke kakahiaka a me ke ahiahi). ʻAʻole kūpono ʻia e lawe i nā papa he 5 ma mua. ʻO Glibometa i kēlā me kēia lā.

Nā hui like ʻana o nā hui nosological

I kekahi manawa pono, ʻoiai inā hiki aku i nā maʻi maʻi maʻi e pono ai i kekahi mau lāʻau e hoʻoponopono ai i ke kō koko. ʻO kaʻoiaʻiʻo, ma nā mākeke pharmacological o kēia manawa he nui nā lāʻau lapaʻau. Akā ʻōlelo pinepine nā poʻe loea i ka lāʻau "Glibomet." Nā hōʻike o nā maʻi maʻi a me nā kauka e hōʻike nei i kēia lāʻau e hiki ai iā ʻoe ke hoʻokō i nā kūlana pilikia.

ʻO ka wehewehe ʻana o ka haku mele. Puka i ka Hoʻolaha Kauka

Loaʻa ka lāʻau lapaʻau "Glibomet" i ke ʻano o nā papa hāmeʻa keʻokeʻo me kahi puʻu paʻakikī. Hoʻokomo ʻia lākou ma nā pololi kūpono o 20 mau ʻāpana. Ma loko o ke kalapona hiki iā ʻoe ke kūʻai i kahi pūpū me nā waihona ʻelua.

ʻO kēia kahi mea hana i hui pū ʻia, no laila, ke hui pū ʻia nā mea ʻelua hana - glibenclamide (2,5 ml i hoʻokahi papa) a me ka metformin i ke ʻano o ka hydrochloride. ʻO ka pono, aia ka mākaukau i ka mea me nā mea kōkua, inā paha, ka pauka palaoa, silicon dioxide, microcrystalline cellulose, talc, diethyl phthalate, glycerin, cellulose acetate phthalate, gelatin.

Pehea ka hopena o ka lāʻau lapaʻau i ke kino?

ʻO kaʻoiaʻiʻo, e hoʻomaka me, he mea kūpono e hoʻomaopopo i ka waiwai o ka lāʻau. Hoʻoholo ʻia ka hopena hypoglycemic o ka hoʻomākaukau ʻana no Glibomet e ke ʻano o nā mea ʻelua ʻelua i ka manawa hoʻokahi.

Hoʻohana kēia mea hana i ka pancreas, ʻo ia hoʻi nā wahi e kuleana ana i ke kino. I ka manawa like, hoʻonui ka lāʻau i ka maʻi o nā ʻōpiopio ʻona o kēia hormone. No laila, kōkua ʻo Glibomet e hoʻohaʻahaʻa i ke kō koko koko me ka ʻole o ka hoʻohana ʻana i ka insulin synthetic, kahi mea koʻikoʻi loa no ka maʻi diabetes type 2.

Loaʻa i ka lāʻau i nā waiwai lipid-hoʻohaʻahaʻa. Ma lalo o kona mana, e hoʻemi ana ka pae o ka momona i ke koko, e hoʻemi ana i ka hōʻemi o nā clots i loko o ke koko (clots getih). Aia ʻo Metformin i ka hui o nā biguanides. Hoʻopuka kēia mea i nā kaʻina hana o ka hoʻohanaʻana i ka glucose e nā ʻōpū, pale i ka gluconeogenesis i loko o nā koʻala o ka ate, a pale aku i ka adsorption o nā kalama e ka paia o ka ʻili.

Hoʻopili koke ʻia ʻo Glibenclamide e nā paia o ka ʻōpū a kokoke i kēlā me kēia (97%) i hoʻopaʻa ʻia i nā protein plasma. I loko o nā puʻuwai, e wāwahi ia, hana i nā metabolites hana ʻole, kahi e hoʻoiho ʻia aku ai mai ke kino aku me nā feces a me ka urine. ʻO ka hapalua-ola kahi 5 hola. Hoʻoulu koke ka Metformin i ke kino, akāʻaʻole paʻa i ka protein plasma. ʻAʻole kala ʻia kēia waiwai ma ke kino. like me na hora elua.

I ka wā e hoʻohana ʻia ai ka lāʻau lapaʻau?

Ua nui ka poʻe i kahi maʻi e like me ka maʻi diabetes type 2. He mea nui loa ka ʻaihue a me ka mālama ʻana i kēia hihia. Ma ke kānāwai, no ka poʻe maʻi nā mea e pono ai ka meaʻai kūpono. Hiki iā ʻoe ke hoʻoponopono i kāu kō koko koko me ka sulfonylureas.

ʻO ka lāʻau lapaʻau "Glibomet" i ʻōlelo ʻia inā he lāʻau lapaʻau e lawe ana a me ka lawe ʻana i nā kālā i luna aʻe, ʻaʻole ia e hāʻawi i ka hopena pono.

Pehea e lawe ai i ka lāʻau lapaʻau "Glibomet"? Hoʻoholo kū hoʻokahi ka Dosage i hoʻokahi. Ma ke ʻano he kānāwai, ʻelua mau papa ʻelua. Lawe ʻia lākou me ka meaʻai. Eia kekahi, hoʻonui ʻia ka nui o ka lāʻau e hoʻokō ai i ka hopena kiʻekiʻe. ʻAʻole pono nā lā o kēlā me kēia lā e 2 g o ka metformin. Ma hope, ua hōʻemi ka wili.

ʻO ka lāʻau "Glibomet": contraindications no ka mālamaʻana

ʻO kahi lāʻau lapaʻau koʻikoʻi maikaʻi loa kēia, ʻo ka hoʻokipa ʻana i ka mea e hiki ke ʻae ʻia me ka ʻae ʻana o ke kauka. He hōʻano kupanaha nā lāʻau lapaʻau e pili ana i nā contraindications, kahi āu e hoʻomaʻamaʻa ai iā ʻoe iho ma mua o ka hoʻomaka ʻana o ka mālama ʻana.

• hypersensitivity o nā mea ikaika a me nā mea kōkua o nā papa,
• ka maʻi pili i nā derivatives sulfonylurea, a me ka sulfamide, probenecid a sulfamide diuretics paha,
• contraindicated kēia mākaukau i ka wahine i ka wā hāpai,
• ka nele o ka hopena mai ka hopena,
• maʻiʻeleʻele coma a me nā kūlana predomatous
• pilikia maoli pilikia
• huehue
• nā maʻi ʻohi
• nā maʻi a me nā maʻi e hiki ke alakaʻi i ka hoʻomohala ʻana i ka kiko hypoxia,
• nā maʻi ākea o ka ʻōnaehana cardiovascular, ka hoʻohui pū ʻana me nā pilikia me ke kaila o peripheral, ka huina myocardial, ka maʻi pehu a me ka weliweli cardiov,
• nā maʻi ʻeha mua o ka ʻōnaehana hanu,
• myocardial infarction a hoʻoponopono manawa paha ma hope o ia,
• ka hana like me ka diuretics a me nā lāʻau lā no ke koko kiʻekiʻe,
• acidosis a i ʻole ka pilikia o kona hoʻomohala ʻana,
• ka heleʻana o ka moʻolelo o ka mea maʻi ma nā hihia o ka lactic acidosis,
• maʻi ʻino ʻeha
• nā pilikia hoʻi o ka ʻōnaehana hanu,
• Hoʻoulu hou ʻia ma hope o ka hoʻokaʻawale ʻana o nā pancreas,
• halawai holookoa,
• inu waiʻuhā, kahi ʻano o ka inu ʻakaʻaka.
• ka hopena wailua
• gangenne
• lactation
• ka hookeai ana paha ma kaʻai ʻana i kahi meaʻai paʻa.

Inā loaʻa ʻoe kekahi o nā contraindications ma luna, a laila pono e hōʻike ʻia i ka endocrinologist.

He aha nā hopena maikaʻiʻole hiki ke alakaʻi i ka lāʻau?

Manaʻo mau ʻia ka palekana e lawe i nā papa Glibomet? Hiki i nā hopena ʻokoʻa ma ke ʻano o ka mālama ʻana. ʻO nā hihia o kā lākou hanana, akā naʻe, ʻaʻole i kākau pinepine ʻia, akā hiki i ka lawelawe ke hōʻeha i nā ʻōnaehana like ʻole.

• Pūnaehana limu a me ke koko . ^ E Ha yM. Hemolytic anemia, leukopenia, thrombocytopenia, pancytopenia, erythrocytopenia.
• CNS . ^ E Ha yM. He wā hōʻeha i ka ʻeha, ka hoʻāʻo ʻana i ka ʻono.
• Nā Organs o ka hihiʻo. ʻO nā hemahema o ka noho, kahi i hoʻemi ʻia i ka acuity ʻike, kahi i hoʻopili ʻia me kahi loli o ke kō koko koko.
• Hāpai . ^ E Ha yM. ʻO ke hoʻonui koʻikoʻi ma ke kaumaha o ke kino, hypoglycemia, lactic acidosis. ʻO ke kaʻina lōʻihi o ka manawa kekahi e alakaʻi i ka hoʻopio ʻana o ka vitamin B12 i loko o ka ʻawaʻawa, a ma hope ke kākoʻo ʻana i ka hana megaloblastic.
• ʻŌnaehana nenoaiu . ^ E Ha yM. ʻO ka ale, ka luaʻi, ka ʻūhū, ka ʻeha i ka ʻāina epigastric, ke kāʻei pinepine ʻana, ka nalo ʻana o ka makemake, ka ʻano o ke ʻano o ka metallic o loko o ka waha, i ka piha o ka ʻōpū.
• ʻO ka ʻili a me ke kiko kikoʻī . ^ E Ha yM. ʻO ka ʻeha ʻili, erythema, nā ʻano like ʻole o ka exanthema, hoʻonui i ka mālamalama o ka ʻili o ke kino i ka mālamalama, dermatitis allergic, urticaria.
• Allergic hopena pili . ^ E Ha yM. ʻO nā ʻeha ma ka ʻili, ka huehue, ka jaundice, ke emi ʻana o ka nui o ke koko, ke kaumaha ʻana i ke kaumaha, nā ʻano haʻalulu.
• Pāʻālua . ^ E Ha yM. Intesthiatic cholestasis, lāʻau lapaʻau maʻi.
• ʻO kekahi mau ʻōuli'ē aʻe e ʻike ʻia, ʻoi aku ka nui o ka nui o ka urine, ka nalowale o ka protein a me ka sodium e ka kino ma muli o ka hopena filtration i loko o nā pūpū.

He mea nui ia e ʻike ʻole ʻia ka hapa nui o nā hoʻopiʻi ma luna nei ʻaʻole pono e hoʻokuʻu i ka hopena o ka maʻi - ua lawa ia e hōʻemi i ka nui o nā maʻi a me nā hopena ʻino e hele ana ma kā lākou iho. Pono ke hoʻonui o kēlā me kēia lā o ka lāʻau lapaʻau a lūlū a mālie.

Hōʻike e pili ana i nā kamaʻilio me nā lāʻau lapaʻau ʻē aʻe

ʻAʻole hiki ke lawe ʻia ka lāʻau "Glibomet" (metformin) me ka waiʻona ethyl, no ka mea e hoʻonui ai i ka hoʻomohala ʻana i ka waikena lactic. I ka wā o ka maʻi, pono e hoʻoneʻe ʻia ka wai a me nā mea inu wai.

Hoʻohana ʻia ka hoʻohana ʻana o kēia lāʻau lapaʻau he 48 mau hola ma mua o nā kaʻina hana a nā iodine e pili ana i nā kūlike. ʻO ka hoʻohana pinepine ʻana i kēia mau lāʻau hiki ke alakaʻi i ka hiki ʻana o ka hana ʻole ʻole.

Inā ʻoe e lawe "Glibomet" me insulin, anabolic steroid, beta-adrenergic blockers, tetracycline mau lāʻau lapaʻau, a laila piʻi aʻe ka hopena o ka ulu ʻana o ka hypoglycemia. Pono nā maʻi diabetes e hoʻomaopopo i kā lākou kauka e pili ana i nā lāʻau lapaʻau a lākou e lawe ai.

ʻO nā kumuʻai a me nā analog

I ka lāʻau lapaʻau o kēia wā, hoʻohana pinepine ka lāʻau "Glibomet". ʻO nā loiloi o nā maʻi maʻi, mau hōʻailona a me nā contraindications nā mea, ʻoiaʻiʻo, nā mea nui. Akā ʻaʻole ka mea nui o nā kumu nui. Heʻoiaʻiʻo, paʻakikī ka inoa ʻana i ka helu helu, akā ma ka awelika o ke kumukūʻai o kahi papa he 40 mau papa mai 340 a 380 rubles, ʻoiai ʻaʻole maoli loa.

ʻOiaʻiʻo, ʻaʻole kūpono kēia mau lāʻau no nā maʻi. ʻAi nā nui o nā kūlā kūʻai i ka mākeke o nā mea i kēia manawa. No ka laʻana, me ka maʻi diabetes o ka ʻano lua, e like me ke ʻano he Avandamet, Vokanamet, ʻo Glukovans e hoʻohana pinepine ʻia. ʻAʻole i emi iki pinepine, hoʻokaʻawale ʻia nā maʻi iā Dibizid, Dianorm a i Sinjarji. ʻO kaʻoiaʻiʻo, ʻo ka mea komo i ka endocrinologist hiki ke koho i kahi kikowaena kūpono.

ʻO ka lāʻau "Glibomet": hōʻike i nā maʻi a me nā kauka

Hoʻohana nui ʻia kēia lāʻau lapaʻau i ka lāʻau lapaʻau o kēia wā. Akā he aha ke ʻano o ka nānā ʻana me Glibomet i ke ʻano? Nā hōʻoiaʻike o nā maʻi maʻi, a me nā poʻe loea, hōʻoia i ka lāʻau lapaʻau e hoʻopili maikaʻi me nā hopena o ka mellitus non-insulin-hilinaʻi.

Wahi a nā noiʻi, hoʻōla ka lāʻau i ka ʻāpana o ka pancreas e kuleana no ka synthesis o insulin. Pēlā nō ka mea e koi ʻia no ka maʻi e like me ka maʻi diabetes type 2. He mea nui loa ka ʻaihue a me ka mālama ʻana i kēia hihia.

ʻAʻole hoʻopaʻa pinepine ʻia nā ala hoʻohiwahiwa i ka hana lapaʻau. Hoʻomaikaʻi maikaʻi ʻia ka lāʻau lapaʻau, a he kūpono loa kāna kumukūʻai.

Nā lāʻau lapaʻau a me ka hui pāpaʻi: & nbsp

Hoʻohui ʻia i nā lāʻau lapaʻau

A.10.B.D.02 Metformin a me sulfonamides

Hoʻohui a me nā hoʻohui antiglycemic.

Kahi ka hua o ka sulfonylurea o ka lua o ka hanauna, ma ka hoʻohaʻahaʻa ʻana i ka paepae no ka hoʻoulu ʻana o ka pancreatic β-cells me ka glucose, hoʻoulu i ka mea huna o ka insulin, hoʻonui i kona hoʻokuʻu a me ka pae o ka hoʻopā ana i nā cell target. Hoʻokomo ka hopena hypoglycemic i ka helu o ka hana β-cell.

Hōʻike i ka hoʻohui platelet, aia nā fibrinolytic, hypolipidemic a me nā hopena diuretic nāwaliwali.

Hoʻemi ia i ka komoʻana o ka glucose mai ka pākina a hoʻonui i kona hoʻohana peripheral, e hoʻonui ana i ka ʻike ʻana o nā io i ka insulin, a me ka pale ʻana i ka glucoseoneogenesis i loko o ka ate. Hoʻemi i ke kiʻekiʻe o ka lipoproteins haʻahaʻa haʻahaʻa a me nā triglycerides i loko o ke kō koko. ʻAʻole i kumu i ka hopena hypoglycemic, ʻaʻole e hoʻopilikia i ka mea huna o ka insulin e nā β a sela o ka pancreas. Ma ke kāohi ʻana i kahi mea paʻa o kahi mea hoʻoulu, ʻo ka plasminogen ka kiko i ka hopena fibrinolytic. Mālama a hoʻoikaika paha i ke kaumaha o ke kino.

Ma hope o ka lawelawe waha, ua hoʻoiho ʻia ma ka gastrointestinal tract e 90%. Loaʻa ka ʻike kiʻekiʻe ma ka lolo koko ma hope o 2 mau hola. ʻO ka kamaʻilio pū me nā protein plasma he 95%.

Hoʻoulu ka hopena therapeutic kiʻekiʻe loa i nā hola 7-8 ma hope o ka hoʻokele ʻana. ʻO 12 mau ka lōʻihi o ka hana. Hoʻomau i loko o nā ate.

ʻO ka hoʻopauʻana hapa-ola e hana i 2-10 mau hola. Hoʻopau i nā keiki a me nā feces.

Ma hope o ka lawelawe waha, a hiki i ka 50-60% ke kahili nei i ka ʻeha o ka gastrointestinal. Loaʻa ka ʻā ʻana o ko plasma nui ma hope o nā hola 2. ʻAʻole paʻa i nā protein plasma.

Hoʻomili ia i ka'ōpū o ka mālamuhina, nā kohu salivary, nā ʻōpū a me nā puʻupaʻa.

ʻO ka hapalua-ola kahi 6 hola. Hoʻololi ʻia e nā keiki i loli ʻole.

Hoʻohana ʻia e mālama ia i ka mellitus non-insulin-hilinaʻi.

IV.E10-E14.E11 Mellitus ole-e pili ana i ka lewa mellitus

Kākau i ka mellitus maʻi maʻamau (ka hilinaʻi ʻana o ka insulin), coma, ketoacidosis, intolerance pilikino.

Nā mālamahe: nā maʻi hoʻohālikelike o ka ʻōnaehana endocrine e hoʻopili ana i ka hoʻoneʻe o nā kalalohina: adenohypophysial and adrenocortical insufficiency, thyroid disfunction. ʻLelo ʻia a me ka lactation: ʻO ka ʻōpala a me nā hoʻokele:

ʻO ka hoʻemi ʻana o ke ʻano hui pono o mua me ka metformin a me ka glibenclamide: ʻaʻole pono ka nui o ka hopena mua i kēlā me kēia lā o ka glibenclamide i kēlā me kēia lā (a i ʻole ke ʻano o ka hopena like o kekahi e pili ana i ka sulfonylurea) a me ka metformin i lawe ʻia ma mua. ʻO kēlā me kēia 2 a i hoʻokahi mau pule paha ma hope o ka hoʻomaka ʻana o ka hoʻōla, hoʻoponopono ʻia ke ʻano ma muli o ke ʻano o ka glycemia.

I loko, i ka wā eʻai ai, i kahi hoʻomaka mua o 2.5 mg o glibenclamide a me 500 mg o ka metformin (1 papa) i 2 mau lā i ka lā. Hiki paha ke hoʻonui a hōʻemi paha i ka make (ma muli o ke ʻano o ka glucose i ke koko).

ʻO ka palena kiʻekiʻe loa i kēlā lā i kēlā me kēia lā (2,5 a i ʻole 5 mg o ka glibenclamide a me 500 mg o ka metformin): 4 papa.

Ka wai helu nui (2.5 mg glibenclamide a me 500 mg metformin): 1 papa.

ʻŌnaehana Hematopoietic : jarang - thrombocytopenia, erythrocytopenia, granulocytopenia, hemolytic anemia.

ʻŌnaehana nenoaiu : dyspepsia, nausea, luaʻi, huʻi, maʻi ʻo ka hepatitis, jaundice cholestatic.

ʻŌnaehana musculoskeletal : ʻĀpilikia.

Nā hopena dermatological ʻohiʻala.

ʻŌnaehana papa maʻi : proteinuria.

Pūnaehana waena a me peripheral : ka maʻi maʻamau, paresthesia, ʻāhane hana.

ʻŌnaehana Cardiovascular : tachycardia.

ʻŌnaehana nenoaiu : ka nele o ka momona, constipation, i kekahi manawa - exacerbation o hemorrhoids.

ʻŌnaehana musculoskeletal: ʻO nā hōʻailona o ka lactic acidosis ka spasms o nā uaua keiki.

Hoʻolālā: ke kō i loko, me ka nalowale o ka hoʻomaopopo - intravenous hoʻokele o kahi hopena o 40% dextrose.

Nā mea hoʻohālikelike o ka plasma plasma o ka lāʻau lapaʻau e hoʻonui i ka likenzyme 3A4 cytochrome P450 inhibitors:,.

Hoʻemi ka pae glycemia i ka wā e hoʻohana ai i ka lāʻau lapaʻau me ka diuret thiazide, nā mākia palepae lohi, nā mākau lithium, nā glucocorticoids, isoniazid, sympathomimetics, ka waikui nikotiniki, phenytoin, phenothiazines, heʻano thyroid.

Me ka hoʻohana pū ʻana me ka furosemide, pono ke hoʻēmi ʻana.

ʻO ka inu ʻawaʻawa (ʻoi aku ma luna o ka ʻōpū ʻole) i ka wā o ka mālama ʻana e hoʻoulu ai i ka hopena o ka disulfiram, e hoʻonui ai i ka lactic acid o ka lactic acid i loko o ke koko koko a me ka hopena o ka hypoglycemia.

I ka wā hapai a me ka lactation, me ka mea ma hope o nā hōʻeha a me nā hana nui, hoʻopau ʻia ka lāʻau lapaʻau, a hoʻomau ʻia ka maʻi maʻi me nā inikini insulin.