Kefsepim - nā ʻōlelo aʻoaʻo no ka hoʻohana

Nā hōʻailona no ka hoʻohanaʻana i ka lāʻau lapaʻau Kefsepim i:
- nā maʻi pneumonia (hōʻeha a me ka maʻi nui) e ka Streptococcus pneumoniae (me nā hihia i hui pū me ka bacteriaemia concomitant), Pseudomonas aeruginosa, Klebsiella pneumoniae a i ʻole Enterobacter spp.,
- nā maʻi ʻeha o ka urinary (maʻa mau a me ka ʻole o nā hōʻeha).
- nā maʻi maʻi o ka ʻili a me nā palupalu palupalu,
- nā maʻi ʻeha intra-abdominal (i hui pū me ka metronidazole) i kumu ʻia e ka Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter spp.,
- nā hana hōʻeha i hoʻoulu kū'ē i ke ʻano o ke kūlana immunodeficiency (no ka laʻana, ka neutropenia febrile),
- pale aku i nā maʻi ma ke kaʻa o ka ʻōpū,

Nā hopena hopena

Mai ka pūnaehana hana ʻana: ka ʻōpū, ka nausea, ka luaʻi, ka constipation, ka ʻōpū o ka ʻōpū, ka ʻōpū.
Pūnaehana Cardiovascular: ʻeha ma hope o ka sternum, tachycardia,
Nā maʻi kūlou: kahelehele, ʻeha ʻili, anaphylaxis, kūmole,
Pūnaehana hoʻonaninani waena: nāwaliwali, nāwaliwali, nāʻaiʻole, ka paresthesia, nā hopohopo, ka haunaele, nā kipa,
Pūnaehana hāhā: ʻeha, ʻehaʻeha, pōkole o ka hanu,
Nā kūloko kūloko: me ke alakaʻi intravenous - phlebitis, me ka keʻena intramuscular - hyperemia a me ka ʻeha ma ka wahi i ʻōlelo ʻia.
ʻO nā mea'ē aʻe: asthenia, sweating, vaginitis, peripheral edema, ʻeha hōʻeha, leukopenia, neutropenia, he hoʻonui i ka manawa prothrombin,

Kahawai

Ke hoʻohana nei i ka lāʻau Kefsepim ka wā hiki i ka wā hāpai ke loaʻa i nā pōpō i makemake ʻia i ka makuahine ma mua o ka hiki i ka pūpū.
Inā kūpono, ʻo ka hoʻohana ʻana i ka lāʻau i ka wā lactation e hoʻoholo pono e hoʻopau i ka ʻōpū.

Hoʻopili pū me nā lāʻau ʻē aʻe

Ke hoʻohana nei i nā dosis kiʻekiʻe o aminoglycosides i ka manawa like me ka lāʻau lapaʻau KefsepimE mālama pono e mālama i ka hana renal ma muli o ka nephrotoxicity hiki a me ototoxicity o nā antibiotic aminoglycoside. Ua nānā ʻia ʻo Neprotoxicity ma hope o ka hoʻohana like ʻana o nā cephalosporins me nā diuretics, e like me ka furosemide. ʻO nā lāʻau anti-inflammatory nonsteroidal, e hoʻolohi ana i ka hoʻopau ʻana o nā cephalosporins, e hoʻonui i ka hiki o ke kahe. Ke kulekepeke Kefsepim mai 1 a 40 mg / ml. kūpono a me nā hoʻonā ʻano kūpuna nei: 0.9% pānaehana sodium klorida no ka maʻi ʻona, 5% a me ka hopena o ka glucose% 10% no ka hōʻōlaʻi ʻana, 6M sodium lactate solution no ka ʻomaʻi ʻana, 5% glucose a me 0.9% hopena paʻakai o ka sodium chloride no ka ʻae ʻana, ka hopena o Ringer me ka lactate a me ka papa hana 5% dextrose no ka maʻi. I mea e hiki ai i ka pili ʻana i nā lāʻau lapaʻau me nā lāʻau lapaʻau ʻē aʻe, nā hoʻonā o ke Kefsepim (e like me ka nui o nā antibiotika lactam beta-lactam) ʻaʻole e lawelawe ʻia i ka manawa like me nā hopena o ka metronidazole, vancomycin, gentamicin, tobramycin sulfate a me ka netilmicin sulfate. I ka hihia o ke keila ʻo Kefsepim me kēia mau lāʻau lapaʻau, pono ʻoe e komo i kēlā me kēia antibiotic i kahi kaʻawale.

Nā palapala ʻano:

pauku no ka hoʻonā ʻana no ka hoʻokō intravenous a me intramuscular

i loko o kahi pahu he:

Ke poʻo inoa

Kūkulu, g

0,5 g

1 g

Citepime hydrochloride monohala, helu ʻia me ka cefepime

(a i hiki i ka pH mai ka 4.0 a 6.0)

pauka mai keʻokeʻo a hiki i keʻokeʻo keʻokeʻo.

Ka hana lāʻau lapaʻau

Lapaʻau lāʻau

ʻO Cefepime kahi ākea ākea cephalosporin antibiotic. Hoʻopili ka Cepepime i ka hoʻopili ʻana o nā protein pā selio bakalē, he ākea ka nui o ka hana bactericidal e kūʻē i nā kūleʻa gram-maikaʻi a me nā gram-Negative, ʻo ka hapa nui o nā kūmau e kūpaʻa ana i ka aminoglycosides a i ʻole nā ​​hanauna o ka cephalosporin huakaʻi e like me ceftazidime.

Kūleʻa ka Cepepime i ka hydrolysis o ka hapanui o ka beta-lactamases, he haʻahaʻa haʻahaʻa ia no ka beta-lactamases a komo koke i loko o nā pūpū o nā bacteria-negative bacteria.

Ua hōʻike ʻia he pilina nui loa ka cefepime no ka type 3 penicillin binding protein (PSB), ka pilina pili nui no ka type 2 PSB, a me ka hoʻololi ʻana no ka type 1a a me 16 PSB. Ua loaʻa i ka Cepepime ka hopena bactericidal ma ka laulā o ka maʻi bacteria.

Hoʻohana ʻia ʻo Cepepime e kūʻē i nā microorganism e like me kēia:

ʻO Staphylococcus aureus (me nā ke kīwī e hana ana i ka beta-lactamase), Staphylococcus epidermidis (me nā kuleana o ka hana ʻana i ka beta-lactamase), a me nā mea maʻamau o Staphylococcus spp. C), Streptococcus pneumonia (me nā māla me ka pale ʻana i ke kūpaʻa penicillin - ʻo ka mea hōʻuluʻulu i ka hōʻemi haʻahaʻa he 0.1 a 1 μg / ml), a me nā beta-hemolytic Streptococcus spp. (nā pūʻulu C, G, F), Streptococcus bovis (hui D), Streptococcus spp. nā hui o nā wahine maikaʻi,

Kākau: ʻO ka hapa nui o nā kūmole enterococcal, e like me ka Enterococcus faecalis, a me ka staphylococci-methicillin-resistant i ka hapanui o nā antibiotics cephalosporin, me ka cefepime.

Acinetobacter calcoaceticus (sub-strains of anitratus, lwofii),
Aeromonas hydrophila,
Capnocytophaga spp.,
Citrobacter spp. (komo pū me nā Citrobacterus, Citrobacter freundii),
Ke
Enterobacter spp. (e komo pū ana me Enterobacter cloacae, Enterobacter aerogenes, Enterobacter sakazakii),
Kalei coli,
ʻOla nani ʻoi,
Haemophilus ducreyi,
Haemophilus influenzae (me ka pū o ka beta-lactamase e hana nei i nā kaha).
Haemophilus parainfluenzae, Hafnia alvei,
Klebsiella spp. (me Klebsiella pneumoniae, Klebsiella oxytoca, Klebsiella ozaenae),
Legionella spp.,
Morganella morganii,
ʻO ka Moraxella catarrhalis (Branhamella catarrhalis) (me ka hana o nā kahe i hana i ka beta-lactamase),
Neisseria gonorrhoeae (me nā pūlima e hana ana i ka beta-lactamase),
Neisseria meningitidis,
ʻO Pantoea aglomerans (ma mua o ka inoa ʻo Enterobacter agglomerans),
Proteus spp. (komo pū pū kekahi ʻo Proteus mirabilis a me Proteus vulgaris),
Providencia spp. (komo pū me ʻo Providencia rettgeri, Providencia stuartii),
Pseudomonas spp. (me Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas stutzer),
Salmonella spp.,
Serratia spp. ((me Serratia marcescens, Serratia liquefaciens),
Shigella spp.,
ʻO Yersinia enterocolitica,

Hoʻomaopopo: Hoʻopau ʻole ke cefepime i nā ʻōpū he nui o Stenotrophomonas maltophilia, ma mua o Xanthomonas maltophilia a me Pseudomonas maltophilia).

Anaerobes:

ʻO nā Bacteroides spp.,
Hoʻolaha Clostridium,
Fusobacterium spp.,
Mobiluncus spp.,
Peptostreptococcus spp.,
ʻO Prevotella melaninogenica (i ʻike ʻia ʻo Bacteroides melaninogenicus),
Veillonella spp.,

Hoʻomaopopo: ʻAʻole ikaika ʻo Cepepime e kū'ē i ka Bacteroides fragilis a me Clostridium difficile. Hoʻomoe mālie ka pale kūʻokoʻa o nā microorganisms i ka cefepime.

Lapaʻau lāʻau

Ka awelika o ka puna wai plasma o ka cefepime i nā pākeke olakino i nā manawa like ʻole ma hope o kahi hoʻokele intravenous hoʻokahi no 30 mau minuke a 12 mau hola a me nā nui o ka nui (C_tah) hāʻawi i ka papa ma lalo.

Average plasma cefepime concentrations (μg / ml) ma hope o ka hoʻokele intravenous.