Pehea e lawe ai i ka Metformin me nā maʻi diabetes type 2?

Hōʻike ʻia kahi hana kūʻokoʻa o ka insulin i ka hoʻokaʻawale ʻāpana o ka hana o kahi hoʻohaʻahaʻa i ka hiona. Hoʻohana ʻia ka lāʻau lapaʻau Metformin no ka maʻi maʻamau ʻo 2 inā ʻaʻole hiki ke mālama i ka waiwai o ka glucose i loko o ka maʻamau (3.3-5.5 mmol / lita) e hoʻohana ana i ka waiʻai kūikawā a me ka hoʻomaʻamaʻa.

Ma muli o ke kaulana kaulana o ka honua, hana ʻia ʻo Metformin ma lalo o nā inoa inoa like ʻole. ʻO kēia ʻaihue hypoglycemic haʻahaʻa i ke koko koko, a pehea e lawe ai i ka Metformin me ka maʻi maʻi, e haʻi aku kēia ʻatikala.

ʻO ka ʻike nui o ka lāʻau lapaʻau

ʻO ka mea wale nō o ka papa o ka biguanides ka metformin hydrochloride. ʻO ka hana ikaika o ka lāʻau Metformin he waiwai maikaʻi a he mahele ia o nā mea he nui i ke kala ʻana i ke kō.

I ke ʻano type type 1, pono e hana ʻia nā inikini insulin i ka wā e pale ai i ka hyperglycemia. I ka maʻi me ka diabetes type 2, kōkua ka metformin e hoʻemi wikiwiki i ka pae glucose me ka alakaʻi ʻana i kahi kūlana hypoglycemic i ka poʻe olakino.

Ke hana nei ka lāʻau maʻi maʻi ma ka pae liʻiliʻi, hoʻonui i ka ʻike ʻana i nā hua i hoʻopaʻa ʻia i ka insulin. I ke kino o ke kanaka, i ka wā e lawe ai i nā paila, he mau loli kēia:

hoʻemi i ka hana o ka glucose i ka ʻili,
ka hoʻomaikaʻi ʻana i ka ʻāʻī o nā cell i ka hormone,
e hoʻohaʻahaʻa ana i ke komo ʻana o ka glucose i ka pā liʻiliʻi,
hana o ke kaʻina hana o ka hoʻoneʻe o nā momona momona,
hoʻohaʻahaʻa i ka cholesterol.

Hoʻomaʻamaʻa mau ka hana maʻamau me ka Metformin i ka pale wale ʻana i ka hoʻonui ʻana i ke kōhi koko, akā e hakakā pū i ka momona. Mahalo nui i nā waiwai o ka lāʻau e hōʻemi i ka makemake.

ʻO ka Metformin ka hōʻemi ʻana i ke kahe o ke koko a me ka hoʻokumu ʻana i nā plas atherosclerotic, e hōʻemi ana i ka hōʻeha o ka puʻuwai a me nā maʻi vascular me ka hoʻomau ʻana o ka maʻi diabetes type 2.

Nā ʻōkuhi no ka hoʻohana ʻana i nā papa

ʻO ka hōʻailona nui e pono ai ʻoe e inu i ka metformin type 2 i ka maʻi maʻamau, paʻakikī e ka hoʻoluhi kaumaha ʻana, i ka wā ʻaʻole i kōkua ka ʻai a me ka hana kino i ka hōʻemi ʻana i ka glycemia.

Ma mua o ka lawe ʻana i ka Metformin no ka maʻi maʻamau o ka lā 2, pono e kamaʻilio pū ʻoe i kahi endocrinologist. ʻO ke kauka, ke nānā nei i ka ʻike o ka glucose a me ka mālama o ka nui o ka mea maʻi, kuhikuhi i ka lāʻau lapaʻau a hoʻoholo i ka helu ʻana. Ma hope o ke kūʻai ʻana i ka lāʻau lapaʻau, pono e hoʻomaʻamaʻa pono ʻia ka lau o ka mea i hoʻopili ʻia.

Aia ma muli o nā kiko o ka mea ikaika o ke kikowaena hypoglycemic, ʻokoʻa nā ʻokoʻa ʻē aʻe:

Nā papa ʻaina 500 mg: nā papa hana i kēlā me kēia lā mai 500 a 1000 mg. I ka hoʻomaka ʻana o nā papa lapaʻau, hiki i ka hiʻohiʻona o nā hopena o ka hopena me kahi indigestion hiki. Kēia mau kaʻina hana ma muli o ke kino e hoʻomaʻamaʻa ai i nā mea hoʻoikaika o ka lāʻau. Ma hope o 2 mau pule, e kū ka hopena a maikaʻiʻole, no laila e hoʻonui ʻia ka hopena i 1500-2000 mg i kēlā me kēia lā. Hoʻoholo ʻia a lawe ʻia ka lōʻihi o 3000 mg i kēlā me kēia lā.
Nā 850 mg papa: i ka mua, ʻo ka dosage ka 850 mg. I ka hoʻomaka ʻana o ke kino o ka mea maʻi i ka hana o ka lāʻau lapaʻau, hiki iā ʻoe ke hoʻonui i kona komo ʻana ma ka hoʻopau ʻana i ka 1700 mg i ka lā. ʻO ka hoʻonui nui loa o ka lāʻau Metformin no nā maʻi maʻi hiki i 2550 mg. ʻAʻole kuhikuhi ʻia nā mea maʻi o nā wā holomua e ʻoi aku i kahi mahele o ka 850 mg.
Nā papa ʻaina 1000 mg: ma ka manawa mua, ʻo ka dosis ka 1000 mg, akā ma hope o 2 mau pule hiki ke hoʻonui ʻia i 2000 mg. Hoʻolaha loa ʻia ka hoʻopau ʻana iā 3000 mg.
Hoʻohana nui a me ka maʻi maʻi o ka insulin: ʻo ka nui o ka helu ma mua o Metformin he 500 a 850 mg paha. Pehea ka nui o ka insulin e pono ai no nā injections, ke koho ke kauka komo.

ʻAʻole hiki ke ʻōmaʻomaʻi ʻia nā papa metformin, ʻu ʻia lākou, e holoi ʻia me ka wai. Pono inu ka lāʻau i ka wā a ma hope o ka ʻaina.

I ke kūʻai ʻana i kahi lāʻau lapaʻau, pono ʻoe e makaʻala i ka lā hoʻopau i hōʻike ʻia ma ka pā. Ua hānai ʻia ʻo ia ma kahi wahi pōkole i kahi mamao loa i nā keiki liʻiliʻi.

Nā hiʻohiʻona a me nā hopena maikaʻiʻole

ʻO ka mea i kākau ʻia e loaʻa kahi papa inoa o nā contraindications a me nā hopena ʻaoʻao.

No laila, pono e hoʻomanawanui ka mea maʻi e pili ana i nā maʻi āpau i pili pū me ka maʻi mellitus i ka wā i kau ʻia ai e ke kauka. Pono paha ka mea maʻi e hoʻopaʻi i kahi maʻi hou.

Hōʻoiaʻiʻo nā ʻōkuhi e pāpā ʻia ka hoʻohana ʻana i nā papa papa diabetes i ke ʻano ʻole o ka makahiki o ka mea maʻi i ka 10 mau makahiki.

Eia kekahi, ʻaʻole hiki iā ʻoe ke lawe i nā kīpoki me:

ʻoi aku ka hanaʻole (hana i loko o ka wahine - ʻoi aku ma mua o 1,4 ml / dl, i nā kāne - ʻoi aku ma mua o 1,5 ml / dl, clearance creatinine - ʻoi aku ma mua o 60 ml / min),
ka pilikino o ke kanaka no ka metformin hydrochloride a me nā mea ʻē aʻe o ka lāʻau,
nā kūlana e hoʻonāukiuki i ka hoʻomaka ʻana o ka lactic acidosis (ka pāʻana o ka puʻuwai, ka nele o ka naʻau, ke kū ʻole ʻana o ka ʻōpū, ka huakaʻi myocardial, ka maʻi cerebrovascular akena),
functioning functioning ate (lua kekona a oi aku paha insufficiency o ka ate e like me Child-Pugh),
ka hoʻokō 'ana no 2 mau lā ma mua a ma hope o ka x-ray, nā radioisotope e nānā me ka hoʻopuka ʻana o ka mea ʻae ʻole.
nā hōʻeha ʻeha a me nā wawaʻi,
lactic acidosis, hōʻike i ka mōʻaukala,
haʻahaʻa-meaʻai kaloria, kahi e hiki ai iā ʻoe ke lawe i ka 1000 kcal i kēlā me kēia lā,
maʻi ketoacidosis maʻi, maʻi kanesa precoma a me ka coma,
lawe ana i kahi keiki a me ka umauma.
inu pia.

ʻO kahi maʻi maʻi maʻi i lawe ʻole i ka Metformin e like me ka mea i mālama ʻia e ke kauka hiki ke helu i kekahi o nā hopena ʻaoʻao:

ʻO kahi mikena CNS: hoʻonāukiuki i nā manaʻo o ka hopena.
Nā maʻi Gastrointestinal: ʻeha o ka ʻōpū, hoʻonui ʻia i ke kūkulu ʻana i ka ʻōpū, ka ʻeha ʻana, ka luaʻi, ka luaʻi ʻana, ka nele o ka makemake. No ka hōʻemi i ka paʻakikī o nā hōʻailona, pono ʻoe e hoʻokaʻawale i ka ʻōpū ma o nā manawa.
ʻO ka hoʻohālikelike Metabola: ka hoʻomohalaʻana o ka hoʻomehana lactic i ka maʻi diabetes.
Hematopoietic system disfunction: ka loaʻa ʻana o ka anemia megaloblastic.
Nā hui kūloko: nā ana ka ʻili, ka erythema, pruritus.
Hōʻeha leʻa: hōʻino i nā hōʻailona nui a me ka hepatitis.
ʻO ka loaʻa ʻana o ka haʻalulu B12.

Inā i ʻike ʻia nā ʻōuli o luna ma ka wā o ka lapaʻau, pono ʻoe e kāpae i ka hoʻohana ʻana i nā papa a ʻimi kōkua i ke kōkua olakino i ka hiki.

ʻO ke kumukūʻai, nā loiloi, nā hōʻike

Hoʻomaopopo pinepine ʻia nā hoʻomākaukau e pili ana i ka metformin hydrochloride ma ka papa waena. Hiki iā ʻoe ke mālama i ke kālā ma ke kūʻai ʻana i nā maʻi diabetes ma ka pūnaewele. ʻO ka kumukūʻai ʻo Metformin ke hilinaʻi nei ma ka waihona:

500 mg (60 papa) - mai 90 a 250 mau rubles,
850 mg (60 papa) - mai 142 a 248 mau rubles,
1000 mg (60 mau papa) - mai 188 a 305 mau rubles.

E like me kāu e ʻike ai, ʻaʻole kiʻekiʻe loa ke kumukūʻai o ka lawena hypoglycemic Metformin, he hoʻohui nui.

Hoʻomaopopo ka loiloi hoʻomanawanui e pili ana i ka lāʻau lapaʻau. Hoʻopau maikaʻi ka metformin i nā pae momona a ʻaʻole i alakaʻi i ka hypoglycemia. Ua ʻae pū kekahi nā kauka i ka hoʻohana ʻana i nā hana antidiabetic. ʻO ka hoʻohana mau ʻana o ka Metformin no ka pale ʻana o ka maʻi cardiovascular a ua uku.

Ke lawe nei kekahi poʻe i ka poʻe ʻole e loaʻa ka lāʻau lapaʻau e hōʻemi i ko lākou paona. ʻAʻole kūkākūkā nā poʻe loea i ka hoʻohana ʻana i kēia lāʻau lapaʻau no ka hoʻohaʻahaʻa ʻana i nā mea olakino.

E pili ana nā hoʻopiʻi koʻikoʻi e pili ana i ka hoʻoneʻe ʻana o ka digestive, e loaʻa ana ma muli o ke kino e hana ai i ka mea ikaika. I kekahi mau māhele o nā mea maʻi, ua ʻōlelo ʻia nā hōʻailona e hoʻōki lākou i ka lawe ʻana iā Metfomin e hoʻemi i ka hoʻoliʻi glucose.

I kekahi manawa lilo i koho i kahi analogue - kahi mea hana e like me nā mea therapeutic like. Akā pehea e hoʻohuli ai iā Metformin? Aia he nui nā lāʻau lapaʻau e like me ke ʻano like me ka hopena:

Metformin Richter,
ʻO ka Metformin teva
Novo-Metformin,
Langerine
Dianormet
Puka Pliva,
Siofor
Metfogamma,
Novoformin,
Lāpai
Hoʻomaka
Diaformin,
Hopu,
Bagometua,
ʻO Glyformin
Kūkākūkā.

ʻAʻole kēia he pau piha o nā huahana i hoʻohana ia e hoʻohaʻahaʻa i ke kō. E kōkua ka mea kauka i ke koho iā ʻoe e koho i ka ʻoi loa ka hopena no ka maʻi diabetes type 2.

ʻO ka Metformin kahi lāʻau lapaʻau maikaʻi e hoʻomaikaʻi i ka pane ʻana o nā pona i hoʻopaʻa ʻia i ka insulin. Hoʻohana ka hoʻohanaʻana o Metformin i ka glycemia, pale i ka hoʻomohala ʻana a hoʻonāukiuki a hoʻonā i ka paona o ka mea maʻi. Ke mālama nei i ka maʻi diabetes ma lalo o ka kaohi ʻana, pono e ukali ʻia nā ʻōlelo aʻoaʻo a kekahi mea loea, a inā i pono, e koho i kahi ʻano kuʻina kūpono.

Ka mea loea i ka wikiō ma kēia ʻatikala e haʻi no ka Metformin.

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana

Loaʻa ka Metformin i ke ʻano o nā papa, i kālai ʻia me ka ʻula keʻokeʻo, oblong a me nā biconvex. I ka palaki maʻamau he 10 mau ʻāpana. ʻO ka mea hana pono ʻo ka Metformin hydrochloride, he keʻokeʻo a ʻulaʻula ʻole paha ka mīkini i ka ʻula. Wikiwiki koke aku la ia i ka wai a i lalo i ka loli maoli i ka acetone, eter a me ka chloroform. ʻO ka momona molekala o ka waiwai o 165.63.

E kamaʻilio e pili ana i nā papa Metformin, pono ʻoe e makaʻala i ka mea maoli:

ma kahi ʻōpū ʻole a ma hope o ka ʻai ʻana i ka meaʻai, hiki iā ia ke hoʻohaʻahaʻa i nā pae i glucose. Hele like no ka hemoglobin glycosylated,
ma muli o ka hoʻohana pono ʻana o ka lāʻau, hoʻonui ka pākia i ka glucose.
ka hoʻoneʻe ʻana o ka ʻawaʻawa (digestive tract, pancreas),
hiki ke hoʻopau ʻia i ka māhele o ka hormonal o nā ʻōnaehana o peripheral.

ʻAʻole kōkua ʻo Metformin i ka loli i ka huna ʻana o nā inehina e nā ʻĀpana beta o nā pilama pancreatic. Eia kekahi, ʻo ia nō ka lāʻau lapaʻau i hōʻike ʻia e hoʻopaʻa i ka pae lipid o ka plasma koko i nā mea maʻi me nā maʻi type 1. Nā papa liʻiliʻi i ka haʻahaʻa o ka triglycerides e like me ka cholesterol. Hoʻohana maikaʻi ka hoʻohana pono ʻana i ka lāʻau i ka paʻa a hōʻemi paha i ka paona kino.

Hoʻomaʻo koke ʻia ka lāʻau mai ke kōnao. ʻO ka bioavailability piha ma luna o kahi ʻōpū ʻūhā mai 50 a 60%. E ʻike ʻia ka lōʻihi o ke kaila o ka plasma ma hope o 120 mau minuke. Hiki i ka ʻai i nā meaʻai ke hōʻemi i ka hoʻokaʻawale ʻana o ka 40% a hoʻolōʻihi i ka hoʻokō ʻana ma mua o 35 mau minuke. ʻO ka hōʻiliʻili o ka mea nui i ka koko e hoʻokō ʻia ma loko o nā hola 24-48 a ʻaʻole iʻoi aku ma mua o 1 μg / ml.

He mea nui e noʻonoʻo e hoʻopaʻa ʻia ka lāʻau i nā protein plasma ma muli o ka hopena. Hiki iā ia ke hoʻokō i nā kūmole salivary, ate a me ka, o nā ʻōpū. Hoʻokuʻu ʻia ʻo Metformin e nā keiki (ma ka maʻamau ma muli o ka honi tubular) i loli (90% ma loko o 24 mau hola).

Nā hōʻailona no ka hoʻohanaʻana i ka lāʻau lapaʻau

Hoʻohana wale ʻia ka lāʻau lapaʻau e hoʻohaʻahaʻa i ke kōhi koko. Me nā maʻi type 1, ʻaʻohe pono e pili i nā papa. Ke ʻōlelo nei i nā kikoʻī hou aku e pili ana i nā ʻōkuhi, mālama lākou i ka type 2 diabetes mellitus i kahi pākeke (ʻoi aku hoʻi i nā mea maʻi me ka hiʻona). Hana ʻia ia me kahi haʻahaʻa haʻahaʻa o ka pono o ka lāʻau lapaʻau kai a me ka hana kino. Hiki ke hoʻohana i ka metformin i ka maʻi diabetes ma ke ʻano monotherapy a i ʻole e hui pū me nā inoa hypoglycemic waha, a me kekahi mau ʻano o nā hana hormonal.

ʻO kekahi hōʻailona hou ke kīpē type 2 i ke keiki i ʻoi aku ma mua o 10 mau makahiki. I kēia hihia, hiki nō ke huli ʻia e like me ka ʻāpana o ka monotherapy a me ka hui pū ʻana me ka māhele hormonal. Holoi nā poʻe loea i kaʻoiaʻiʻo o:

Hiki ke hoʻohana 'ia nā metformin ma hope o ka hana o ke kō koko koko,
i mea e pale aku ai a pale i kahi ala maʻi, ʻoi aku ke ʻano nui o ke ʻano kūkā e kūkākūkā me kahi loea.
e ola wale ka hoʻolaʻa hou inā mālama ka mea maʻi i nā mea maʻamau o ka mea hoʻohālike, nā contraindications a me nā hiʻohiʻona ʻē aʻe.

Pehea e lawe ai iā Metformin no ka maʻi diabetes?

Ua haʻi aku nā poʻe pīpī i nā mea āpau e pili ana i ka maʻi diabetes! E hala aku ka maʻi maʻi i nā lā 10 inā e inu ʻoe ma ke kakahiaka. »Heluhelu hou i ka >>>

Pono e lawe ʻia i nā papa ʻōlelo, ʻoki loa iā lākou a me ka ʻaʻole ʻole. Hiki i kēia ke hana i ka wā ʻai a ma hope koke o ia. He mea nui e inu i ka wai nui me nā papa. No nā poʻe pākeke, hiki ke hoʻohana ʻia ʻo Metformin i loko o kahi hoʻomaka mua o ka nui o ka 1000-1500 mg i loko o 24 mau hola. No ka hōʻemi i nā hopena ʻaoʻao mai nā huehue, e pono e hoʻokaʻawale ʻia ka nui i loko o ʻelua a ʻekolu paha.

Ma hope o nā lā 10-15, inā ʻaʻohe manaʻo ʻino mai ka gastrointestinal tract, e ʻae ʻia ka hoʻonui ʻana o ka ʻōnaehana ʻana ma o dosage. Akā naʻe, ʻaʻole pono ia he kūpono a hilinaʻi ʻia ma ka māhele o ke kō i loko o ke koko. Pono e hoʻomaopopo ʻia he mea maʻalahi ia i ka helu i hiki ke loaʻa i ka hopena maikaʻi no ka hoʻomaikaʻi ʻana i ka pāʻai a me ka hoʻokuʻi ʻole o nā papa.

ʻO ka dosis mālama i ka lā e pono e pili ana i 1500-2000 mg. ʻAʻole keu ka nui o ka mea i hāʻawi ʻia ma mua o ka 3000 mg, a manaʻo ʻia e hoʻokaʻawale ʻia i ʻekolu mau hopena. Ma ke kaʻina hana o ka hoʻololi mai ka hoʻohana ʻana i kahi mea hoʻohālikelike wahaʻaila hypoglycemic hou loa i ka Metformin, uaʻike nui ʻia ʻoe e hoʻohana i ka hoʻohana ʻana a hoʻomaka i ka lawe ʻana iā Metformin Canon ma ka palena haʻahaʻa i hōʻike ʻia ma mua.

Hiki ke hoʻohana ʻia ka lāʻau lapaʻau Metformin no ke ʻano maʻi type 2 i ka hui pū ʻana me ka insulin. Ua koi ikaika ʻia kēlā:

o ka iniha mua a i kauia no 500 mg a me 850 mg ka papa 1 a ʻelua a ʻekolu paha manawa i ka lā,
ʻO ka Metformin 1000 mg ka papa ʻelua i kēlā me kēia 24 hola,
ke koho ʻia o ka helu o ka hormonal i kēia hihia ua kau ʻia ma luna o ke kō.

No nā keiki ma mua o 10 mau makahiki, ʻo ka hopena i manaʻo ʻia e hoʻohana ʻia ʻo Metformin Canon. Hiki ke hoʻohanaʻia e like me ka mahele o ka monotherapy, a me ka ʻāpana o nā hui hui pū me kahi mea hana hormonal. Pono ka hoʻomaka ʻana o ka Metformin ma kēia hihia me kahi laʻu haʻahaʻa ʻoi loa e like me 500 mg hoʻokahi manawa no 24 mau hola i ke ʻano o ka ʻai ʻana i ka meaʻai. Ma hope o nā lā 10-15, e hoʻomaikaʻi ʻia ka nui o ka nui e pili wale ana i ka luhi ʻana o ka glucose i ke koko. ʻO ka papa mālama mālama mai ka 1000 a 1500 mg i ka lā no ka ʻelua a ʻekolu mau pona. Pono ka nui o ka nui loa ma mua o 2000 mg no ka hoʻomau ʻana o ka lā holoʻokoʻa i kēlā me kēia lā.

Ma muli o ka hikiʻole o ka hana renal, ʻo ka nui o ka lāʻau Metformin e noi ʻia no ka poʻe ʻelemakule e koho ʻia me ka mālama mau ʻana i ka hana ʻōpili. ʻO kahi kapu i kēia manaʻo e mālama i ka māhele o ka creatinine i loko o ke koko serum ma kahi o ʻelua a ʻehā paha i kēlā me kēia makahiki. ʻO ka lōʻihi o ka mālamaʻana e hoʻoholo e kahi loea.

Ke kāpae nei i ka hoʻohana ʻana o Metformin me ka ʻole o ka ʻōlelo a ke kauka loea no ke ʻano maʻi type 2 i ʻole ʻia.

Hiki i ka lāʻau ke lawe i ka lōʻihi o nā lā a e hoʻomanaʻo ʻoe e:

i ka manawa e kuhi ana a i ʻole ka heleʻana o ka wā hāpai, hiki ke hōʻoki ʻia ʻo Metformin Canon a hui aku i ka therapy insulin,
he mea nui loa e hoʻomanawanui i ka mea maʻi e koi iā ia e hōʻike iā ia i ka maʻi kuʻikena a me ka mea maʻi maʻi maʻi inā he wā hapai,
pono ka makuahine a me kāna keiki e hoʻokumu i ka nānā.

ʻAʻohe ʻike paʻa e pili ana inā hoʻopili ʻia ʻo Metformin i hui pū me ka waiū umauma. Inā pono ʻoe e hoʻoholo pehea e inu ai i ka Metformin i ka wā o ka hoʻoulu ʻana, e pau ka lactation.

Nā hiʻohiʻona a me nā hopena ʻaoʻao

ʻO ka papa inoa o nā contraindications e pili ana i ka hypersensitivity mua, a me nā ʻano like ʻole o nā palu a me ka hele ʻana o ka renal maikaʻi ʻole. Pono e nānā pono i nā abnormalities maopopo i ka ate, nā kūlana i hui pū ʻia e ka hypoxia (cardiac a me ka hāʻule ʻana o ka hanu, ka mana ma muli o ka myocardial infarction, ka neʻe koko i loko o ka lolo a me ka anemia).

ʻO nā maʻi kikowaena ka dehydration, nā maʻi maʻi maʻi, ka nui o ka hōʻeha ʻana, a me nā hōʻeha like. Mai poina e pili ana i ka wai maʻi kūlohelohe, ʻo ka metabolic acidosis ʻoiola (me ka ketoacidosis maʻi me ka coma) ʻole. ʻO nā hoʻohālike kekahi:

lactic acidosis ma ka mōʻaukala olakino,
ka pono e hahai i kahi papa haʻahaʻa-haʻahaʻa (emi iho ma mua o 1000 kcal i kēlā me kēia lā),
noiʻi me ka hoʻohana ʻana i ka isotopes isotopes o ka iodine,
kekahi o nā mea hoʻomaʻamaʻa o ka hāpai ʻana,
hana waiū.

Aia kekahi mau palena paʻa e pili ana i ka hoʻohana ʻana. Ke kamaʻilio nei mākou e pili ana i nā keiki ma lalo o 10 makahiki, aia ma muli o ka hōʻoia a ʻaʻole palekana ka hoʻomau a palekana. Eia kekahi, pono e uku ʻia i ka wā ʻelemakule (ma mua o 65 mau makahiki) ma muli o kahi metabolism. Eia kekahi, ʻaʻole ia e kuhikuhi ʻia i ka lāʻau lapaʻau i nā poʻe e hana nei i ka hana kūlohelohe nui (ʻo ka ulu ʻia o ka ulu līpika acidosis e hoʻonui ʻia).

ʻO nā hopena ʻaoʻao o ka Metformin mai ka ʻōnaehana o ka hoʻihoʻi ʻana i ke ʻano o ka hoʻihoʻi ʻana e pono e noʻonoʻo pono i ka anorexia, nā maʻi ʻeha, ka luaʻi a me ka luaʻi. Eia kekahi, e hoʻolohe pono ai i ka flatulence a me ka ʻeha ʻeha (hōʻemi i ka wā i hoʻohana ai me ka meaʻai). ʻO kekahi ʻaoʻao ʻē aʻe paha ka hopena metallic i loko o ka waha (i ʻike ʻia ma kahi o 3% o nā hihia).

Ma ka ʻāpana o ka ʻōnaehana cardiac a me ka vascular, a me ke kaʻi ʻana o ke koko a me ka hemostasis, i nā hihia loaʻa ʻole megaloblastic anemia. E like me kāu e ʻike ai, ʻo ia ka hopena o ka destabilization o ka loaʻa ʻana o ka vitamina B12 a me ka acid folic. Loaʻa nā hopena ʻaoʻao i ka pilina me ka metabolism. ʻO ka mea mua, he hypoglycemia kēia. I nā hanana lohi, ke kamaʻilio nei mākou e pili ana i ka lactic acidosis, no ka laʻana, nāwaliwali, ka hiamoe, ke hypotension a me nā hōʻike ʻē aʻe.

Loaʻa paha ke ʻano o nā hopena ʻili e pili pū ana me ka ʻili. E pili i ka hoʻomohalaʻana i ka nui a me ka dermatitis. I mea e hoʻopau ai i nā hopena like, ua noi ikaika ʻia e kūkā mua ʻoe me kahi loea.

Nā kuleana a me nā kūlana e waiho ai

Hoʻomaopopo ʻia e mālama i ka lāʻau i ka mahana ma mua o nā mea 25 kiʻekiʻe. He mea nui ia kahi kēia i hiki ʻole i nā keiki. ʻAe ʻia ka mālama ʻana o Metformin i 24 mau mahina. ʻAʻole ia e noʻonoʻo i ka hoʻohana ʻana ma hope o ka lā pau i hōʻike ʻia i ka pōpoki. Hoʻokuʻu ʻia ka lāʻau lapaʻau e ka lāʻau lapaʻau.

Nā Pili i nā lāʻau lapaʻau me nā lāʻau ʻē aʻe

E hoʻolohe i nā hui contraindicated a ʻaʻole i ʻōlelo ʻia. No laila, ma ka hihia mua mākou e kamaʻilio nei e pili ana i kahi noi radiological e hoʻohana ana i nā lāʻau radiopaque e loaʻa ai ka iodine. Hiki i kēia ke hoʻowalewale i ka hoʻokumu ʻana o ka waosisosis lactic i ka maʻi lolo ma muli o ka pani ʻole ʻana o ka renal.

ʻO nā hui pū ʻia no nā maʻi maʻi maʻi:

ka hana like ʻana o Metformin me nā mea ʻawaʻawa a me nā inoa e noho ana me ka ethanol.
lilo i ka maʻi kūlohelohe,
ka wikiwiki a ʻoki ʻole i kahi meaʻai haʻahaʻa.
nā pūpū ʻole o ka ate, ma kahi e hiki ai i nā mea ʻē aʻe, ua piʻi ka hopena o ka hoʻomohala lactic acidosis.

Aia nō kekahi hui pū kekahi e pono ai ka mālama kūikawā. Ke kamaʻilio nei mākou e pili ana i ka hana like ʻana o Metformin me Danazole ma muli o ka hopena hyperglycemic hopena. Eia nō hoʻi, pono e makaʻala ʻoe i nā lāʻau e like me Chlorpromazine, nā glucocorticosteroids (GCS) ʻē aʻe. Me ka hana like o ka "loop" diuretics a me Metformin, aia kahi hopena o ka hoʻokumuʻana o ka acidact lactic ma muli o ka hana renal hopena.

ʻAʻole hiki i ka Metformin ke kōkua i ka wehe ʻana i ka maʻi maʻi ma o ka hoʻohana ʻana i nā kaha o ka beta--adrenergic beta2-adrenergic, nā mea hoʻoneʻe o ka angiotensin-hoʻohuli i ka enzyme. Eia kekahi, pono e hāʻawi pono i ka mālama ʻana i nā derivatives o sulfonylurea, Nifedipine.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

ʻO ka nui o nā metformin i ka lāʻau lapaʻau o ka inoa like ʻole e ʻokoʻa: ka papa hoʻokahi he 500 a 850 mg o ka hana ikaika. Kuhi i kahi mea hana hypoglycemic lōʻihi e hoʻonui ana i ka 1000 mg o ka metformin ma kahi pākahi.

Hoʻopili ʻia nā papa ʻelua, ʻo ke ʻano he biconvex. Mākaukau ka mākaukau me nā dyye indigo carmine, titanium dioxide, a me ka quinoline melemele. ʻO ka pahu pahu he 30 a 60 mau papa. Nā mea hana - nā hui mai Hungary, Lūkia, ʻIseraʻela.

Nā kikowaena o Metformin

Ke hoʻomau ʻia nei ka maʻi mellitus e ka DIABETOLOGIST me ka ʻike iā Aleksey Grigorievich Korotkevich! "." heluhelu hou aku >>>

Siofor, Bagomet, Glycomet a me Glikovin - he papa kuhikuhi wale nō kēia o nā analogues o nā kālā i hōʻike ʻia. Hoʻohui ʻia ka papa inoa i nā inoa e like me Glyunet, Dianormet, Diaformin, Insufor a me nā mea ʻē aʻe. E hoʻoholo i ka mea ʻoi aku ka maikaʻi, ʻo Siofor a i ʻole Metformin, e kōkua wale i ka maʻi maʻi. ʻAʻole kūpono ʻia ke kuhikuhi ʻana i kekahi a i ʻole kekahi analog kekahi iā ʻoe iho.

Ka hana i ke kino

He hopena maikaʻi ka lāʻau kūlohelohe i ka hoʻoliʻi a me ka lipid metabolism, hana i nā hoʻokaʻina glucose o ke koko, pale i ka hyperglycemia e pili ana i ka mua o ka maʻi mua a me ka lua. ʻO nā papa metformin e kūleʻa ana i ka hoʻomaka o ka maʻi mellitus o ka maʻi diabetes a me ke kūpaʻa ʻana i ke kua o ke ala lōʻihi o ka hoʻokō endocrine pathology.

ʻO ka pono o ka hōʻike peripheral (ʻaʻohe hopena o nā cell pancreatic). ʻAʻole ia he mea kupanaha a ʻo ke lawe ʻana iā Metformin, i ka helu ʻana i ke ʻano kūpono o ka hopena, ʻaʻole ka hāʻule o ke koko koko i nā pae koʻikoʻi. ʻO ka liʻiliʻi loa o ka hypoglycemia e hoʻohālikelike ana i ka māka antidiabetic me nā lāʻau lapaʻau ʻē aʻe e hoʻopiʻi i ka pathology endocrine.

I ka wā o ka mālama maʻi, ua emi ka nui o ka pale ʻana i ka insulin, ua hoʻemi ʻia ka glucose mai ka huehue ʻole ʻia. ʻO kahi kūpono i ka pale ʻana o ka hoʻokuʻu ʻana o ka glycogen mai nā hepatocytes, ka wikiwiki o ka hoʻopau ʻana a me ka hoʻopauʻana i ka kolamu "maikaʻi". I ka wā maʻi, hoʻonui ʻia ka glucose i nā uaua.

E aʻo e pili ana i nā hōʻailona o ka adrenal insufficiency i nā wahine, a me nā lula no ka mālama ʻana i nā patology.

E heluhelu e pili ana i ka hana maʻamau o ka hormone thyroid-hoʻoikaika i ka wahine a me ka kāne, a me e pili ana i kāna mau hana i ke kino ma kēia kiko.

Nā hōʻailona no ka hoʻohana ʻana

Ke kuhikuhi ʻia nei kahi lāʻau e pili ana i ka metformin:

me ka lānu-ole-hilinaʻi (II) ʻano o ka maʻi maʻi ma ka lālani hua lāʻau mua-laina. ʻO ka mea hoʻohana nui hypoglycemic pono e lawe i kēlā me kēia lā. Ke hoʻomau nei nā pae glucose i ke koko, lipid a me ka hoʻoliʻiʻana o nā metabolism, e hoʻemi ʻia ka nui o ka hewa.
me kahi insulin-hilinaʻi (I) ʻano o ka maʻi endocrine i hoʻopili ʻia i nā inikini insulin. ʻO ka emi ʻana o ke kaʻe o ka glucose i hui pū ʻia me ka maikaʻi o ka intake insulin e hoʻomaikaʻi ana i ka uku o ka maʻi diabetes. Ke hui pū ʻia ka hormone-accumulator me Metformin, hoʻemi ʻia ka hopena o nā hōʻeha paʻakikī: rhinopathy diabetes, neuropathy a me nephropathy, vascular, lesi o ka ʻili, a me ka liʻiliʻi o ka hōʻike ʻana o ka hypertension arterial.

ʻO ke kānāwai o Metformin

ʻO ka mea hana ikaika ka metformin hydrochloride. Mai ka papa o nā biguanides, ʻo ia wale nō ka mea i loaʻa i ka hopena therapeutic maikaʻi. Manaʻo nā loiloi maʻi maʻi e ʻoi aku ka maikaʻi o kēia lāʻau ma mua o nā mea ʻē aʻe i kāna papa. ʻO kēia ma muli o ka hana i ka hana i ka pae ʻai, e hoʻonui ana i ko lākou naʻau i ka insulin. Mahalo i ka hoʻomaʻamaʻa ʻana o Metformin, ua nānā ʻia nā hopena like ʻole:

kālai ʻia ke ate i ka liʻiliʻi o ka glucose,
ʻoi aku ka nui o nā momona momona e hoʻomaka ai e hoʻonui.
lilo i nā ʻāpana ke maʻalahi i ka insulin,
hoʻemi ʻia ka glucose i loko o ka pā liʻiliʻi,
hoʻomaka ka naʻau i ka nui o ka glucose,
ʻāpana hapa o ka glucose i ka wā kahili a lilo i lactate (lactic acid).

Pēlā e hōʻemi ai ka lāʻau lapaʻau i ke kōʻai koko i ke kūpaʻa ʻole, ʻoiai kona hopena koʻikoʻi ka hoʻonui ʻana i ka noʻonoʻo o ke kino i ka insulin.

Ma muli o ka mea i hoʻoulu ʻia e ka huahana nā oxidation o nā momona momona, kū hou mai nā hopena therapeutic e hoʻonui i ka pūʻulu o nā mea i manaʻo ʻia e inu i ka Metformin. Eia ka penei:

ke kau nei i ke kīpē o atherosclerotic vascular plaets
emi ka nui o ke kino, ka mea e hoʻopilikia kino i ka mālamaʻana i ka metabolic syndrome,
neʻe kaʻai koko.

Pono e noʻonoʻoʻia o ka kaʻina o ka oxidation o nā momona momona i kūpono i kā lākou luku a hoʻololi i ka ikehu. No laila, e hoʻemi ʻia nā mālama momona, lilo ke kino i ʻano haʻahaʻa. No laila, e hoʻohana pinepine ʻia ka lāʻau lapaʻau no ka mea kaumaha, no ka mea e hoʻoulu i ka wela o ka momona.

Me ka maʻi maʻi maʻi 1

ʻO ka nui o nā mea hana i hana pinepine ʻia e ka endocrinologist ma muli o ke kaha o ka insulin. E noʻonoʻo e noʻonoʻo i ka kiʻekiʻe o ka glycemia. Hoʻohālikelike ka lōʻihi o ka hoʻohana ʻana o Metformin e ka neʻe ʻana o ke kauka i ka noʻonoʻo i ka hopena therapeutic o ka hui pū ʻana o ka hormone-accumulator me kahi hoʻokaʻaʻaina gula.

Me ke ʻano o nā ala 2 ʻano

ʻO ka awelika nui o kēlā me kēia lā he 1 papa, ka nui o ka waihona kaha he 850 a 500 mg paha. No ka hōʻemiʻana i ka makaʻuʻole i ka digestive tract, ʻae ʻia e ka lāʻau lapaʻau i ka wā ʻai. Me ka hoʻomanawanui maikaʻi o ka metformin, ka nalowale o ka nausea a me ka bloating, ua hoʻolālā ʻia e loaʻa nā papa 30 mau minuke ma hope o ka ʻaina.

Inā ʻaʻole haʻahaʻa ka nui o ke kō, hiki i ka endocrinologist ke hoʻonui i ka helu o kēlā me kēia lā i 2000 mg. Hoʻohui ka hui pū me ka derafaea sulfanilurea, hoʻemi ʻia ka hoʻokaʻina o ke kōpaʻa ma ka hapakolu a ʻoi paha.

ʻO nā ʻaoʻao maikaʻi ʻole o ka lawe ʻana iā Metformin

Hoʻomaʻamaʻa ka lāʻau lapaʻau a me nā loiloi hoʻomanawanui e loaʻa nā hopena maikaʻi i kēia hypoglycemic. ʻO kēia ma muli o ka hana i hoʻonui ʻia i ka oxidation o nā lipids. Ma ka hana o kēia kaʻina hana biochemical, ʻaʻole i hoʻoulu ʻia ka nui o ka ikehu wale nō, akā ua lactate (ka lactic acid), ka mea nui e alakaʻi i ka acidosis, ʻo ia hoʻi, kahi hoʻololi o ka hydrogen index i ka ʻaoʻao o ka acid. ʻO kēia ka mea, ʻoi aku ka nui o nā waikawa i loko o ke koko ma mua o ka mea e pono ai, kahi e hoʻopiʻi i ka hana a nā mea āpau a me nā ʻōnaehana a hiki i ka make.

Hiki i ka acidosis lactic ke hele a kūleʻa a hoʻomaikaʻi iki. ʻO ka maʻamau, he ʻoluʻolu a maʻalahi hoʻi kāna mau hōʻailona, akā i kekahi manawa e hiki ke hōʻeha i ka wā e koi ʻia ʻo ka dialysis (ʻo ia hoʻi, ʻo ka hoʻopili ʻana i kahi huapau maoli i ka pā. ʻO nā huaʻōlelo o ka lactic acidosis nā mea penei:

I kekahi mau mea maʻi, hiki i ka metformin ke hōʻeha i nā ʻeha a me nā ʻōpū.

ke ʻano o ka nāwaliwali
hiamoe
āhāhuʻe
puʻu papaʻu
ʻaʻano pōkole
haʻahaʻa mau koko
haʻahaʻa haʻahaʻa kino
ʻāʻā hoowili, etc.

Hoʻomaʻamaʻa ka mālama ʻia o ka acidact lactic maʻa mau, i nā hihia loaʻa, neʻe ʻia ka hemodialysis (kahi hana kūikawā no ka hoʻomaʻemaʻe koko.

Loaʻa nā hopena maikaʻi loa

ʻO kahi hopena maikaʻiʻole i ka wā e hoʻohana ai i ka lāʻau Metformin hiki i kahi ulu pinepine. Me ka hoʻowalewale kūlohelohe, maʻi āpau, hiki ke hōʻuluʻulu i ka stool, ʻoluʻolu ʻole i ka digestive tract, ʻokoʻa ka hoʻololi ʻana, hiki i ka flatulence. E kūʻē i ke kūmole o ka anemia megaloblastic, me ka loaʻa o ka loaʻa pinepine o kahi māpē hypoglycemic, he hopena o ka hoʻoliʻi ʻana o ka vitamin B12.

ʻO nā hopena ʻē aʻe o ka pūlohi hypoglycemic (erythema, urticaria, kaʻeha ʻili, ke kāʻei o ka naʻau o nā enzymes). Ma hope o ka hoʻokuʻu ʻana i ka lāʻau a hōʻemi paha i kēlā me kēia lā, pau nā hopena maikaʻi ʻole.

Lactic acidosis: he aha ia

ʻO ka loaʻa pinepine, akā ʻo ka hoʻopiʻi weliweli loa me ka hoʻohana ʻana o Metformin. Hoʻoulu i kahi maʻi metabolic me ka hōʻiliʻili o ka waiwai ikaika i nā kiko. ʻO ka pinepine loa, ʻike ʻia ka acidact lactic i ka mālama ʻole ʻana i ka contraindication e like me ka hana ʻole. Ma ka ʻike ʻoi ʻole ʻana o ka hiki ʻole o ka maikaʻi o ka pale a me ka hana ʻole ʻana i ka pilikia o ka maʻi, ka hoʻomaka ʻana o ke ʻano o ka mālama ʻana, ka nui wikiwiki ʻana i nā hōʻailona hōʻailona me ka nānā ʻana o ka paʻakikī o nā hōʻailona maikaʻi ʻole.

Pono e ʻike ʻia nā mea hōʻike o ka lactic acidosis e nā maʻi maʻi a me nā ʻohana. Ke kau ʻana i kahi maʻi o ka mea maʻi i kahi keʻena olakino no ka maʻi ikaika e hoʻopau ʻia me kahi como ketoacidotic a me ka make.

ho? i kahi kikowaena i ke kumu,
ʻeha nui ka ʻōpū
ka haki i ke kō,
nāwaliwali
lima lulu
wikiwiki wikiwiki (acidic shortness o ka hanu),
nā ninia
hoʻomāʻeha ʻokoʻa
nalowale o ka ike ana.

pauku electrolyte,
serum lactate he 5 mmol / l a i ʻole,
emi i ke kahe o ke koko,
ka kuʻe ʻana o ka pae o ka lactate a me ka pyruvate.

ʻO nā hōʻailona o ka hoʻomohalaʻana i ka acidosis lactic e koi koke i kahi hoʻopiʻi. Ma mua o ka hiki ʻana o kahi hui lapaʻau, ʻaʻole pono e hāʻawi i ka mea maʻi Metformin a me nā inoa i hoʻemi i ka pae o ka glycemia.

E ʻike i kahi papa kuhikuhi no ka wiki 9 o ka papa helu 2 no ka maʻi type 2.

ʻO nā lula a me nā hiʻohiʻona o ka hoʻohana ʻana o nā papa Triiodothyronine i ka mālama ʻana i nā maʻi thyroid ua wehewehe i kēia ʻaoʻao.

E hele aku i http://vse-o-gormonah.com/vnutrennaja-sekretsija/nadpochechniki/giperplaziya.html a e aʻo e pili ana i nā hōʻailona ʻano a me nā hana kūpono no ka hyperplasia adrenal.

Pehea e hana ai ka lāʻau lapaʻau?

He hopena koʻikoʻi ka Metformin i ka maʻi diabetes. ʻO kāna hana nui, ʻo ia ka hoʻohaʻahaʻa i ke kōhi koko. Eia nō naʻe, i ka manawa like, ʻaʻole pilikino nā ʻōnaehana kino.

Hoʻomaikaʻi kēia mau papa ʻōlelo no ka type 2 diabetes mellitus i ka hoʻopili ʻana o nā glucose e nā kiko, ʻoi aku ka ʻiʻo, ʻaʻole lawa nā maʻi maʻi. E hoʻomanaʻo no ka hana muscular pono ʻoe i kahi hoʻoikaika kino kino.

Kōkua nā papa mai ka maʻi e hōʻemi i ka hoʻoneʻe ʻana o nā hāmeʻe i loko o ke ake, a hoʻomaikaʻi pū kekahi i nā metabolid lipid ma ke kino. Me ka maʻi type 2, mea nui ka metabolism.

Me nā maʻi papa ʻaina 2, he mea nui e mālama pono, e pale i ka overeating a me ke kaumaha. E hoʻokaʻawale nā ʻōpala i nā lāʻau lapaʻau, akā ʻaʻole kēia e pono ke hāʻawi i ka hana kūpono a me ka hana kino.

Eia kekahi, ʻo ka lāʻau lapaʻau no kēia maʻi he hopena maikaʻi i ka pūnaehana cardiovascular a me ka digestive o ke kino.

Nā maʻi hoʻohālikelike i ka hoʻohana ʻana i ka lāʻau

Keʻike nei kekahi poʻe maʻi e pili ʻole kēia ʻano lāʻau. ʻAʻole kēia ka hihia, ʻo ka hōʻeha o kekahi lāʻau lapaʻau e hiki ai ke pilikia i ke olakino olakino. ʻAʻole hiki iā ʻoe ke inu i ka metformin i nā hihia.

ʻO ka hapai a me ka umauma,
Inā ʻaʻohe maʻi maʻamau,
ʻO nā maʻi o ka puka mua,
Inā ua loaʻa i kahi maʻi kahi ʻano decompensated,
Nā pilikia pilikia o kidney
Nā pilikia o ka naʻau a me ka pūpū
ʻO ka manawa mua ma hope o ka infarction myocardial,
ʻO ke kaʻina hana ma hope o ka hana nui,
Inā hele ka maʻi maʻi ma kahi alanilima,
Inā hele kahi maʻi ma ke kino,
ʻO ka hapa hao
Allergic reaksi a me nā mea o ka lāʻau,
Hoʻohālikelike waiʻona,
Inā ʻoe he pālono o nā meaʻai i lalo i loko o nā kalori (ʻoi ʻoi loa ka maikaʻi no ke kanaka olakino).

Pono e hoʻokaʻawale ʻia ka lāʻau no ka maʻi type 2 inā loaʻa ʻole i kahi mea e pili ana iā ʻoe.

Nā hopena hopena

Ma kahi o ka overdose, mālama pono-iho, mālama i nā ʻōlelo a me nā ʻōlelo a ke kauka, hiki i nā hopena ʻaoʻao. Hiki i nā mea lapaʻau me ka metformin ke alakaʻi i nā hopena like ʻole:

Kahula
Ka helu ʻokoʻa a ʻāpana ʻole paha.
Lohea
Nā maʻi maʻi
Ka emi iki ʻana o ka mahana o ke kino,
ʻO ka ʻehaʻeha o ka ʻiʻo
Paha a luhi,
Hanu wikiwiki
I ka piko maʻi maʻi
ʻO nā pilikia me ka ʻike o ka honua,
Inā ʻoe e lawe ana i ka metformin no ka maʻi maʻamau me nā lāʻau lapaʻau ʻē aʻe, hiki i kēia hōʻiliʻili ke kumu i ka hypoglycemia.

Hiki ke lawe i ka metformin ma hope o kēia mau hōʻailona? ʻAʻole ʻaʻole paha. Eia kekahi, ma nā hōʻailona mua o ka hiki ʻole o ke ʻano kūpono o ke kino i ka lāʻau lapaʻau, pono ʻoe e nīnau i ke kauka e kaukaʻi i ka mālama ʻana. ʻO ka hopena no ka maʻi maʻi type 2 he mamao loa i ka mālama pono ʻana i ke olakino. Inā hoʻohana pono ʻole, hiki iā ia ke alakaʻi i ka make.

Nā maʻi hoʻohālikelike i ka hoʻohana ʻana o Metformin

ʻAʻole e hoʻohana ʻia kahi lālā no ka mālama ʻana i ka maʻi maʻi i nā maʻi penei:

i ka wā hāpai a me ka lactation,
keiki malalo o 10 makahiki
haʻahaʻa meaʻai haʻahaʻa
ma hope o ka hana a me nā hōʻeha
me nā maʻi kalima,
me nā maʻa lactic acidosis o mua,
inā loaʻa kahi lactic acidosis,
i ka heleʻana o kahi o ka renal i ke anamnesis.

Pehea e lawe ai i ka metformin?

He mea nui ia no nā maʻi e makemake e hoʻōla ʻia o ka nui o ka glucose i loko o ke koko e ʻike ai pehea e lawe ai i ka metformin me ka maʻi diabetes. Pono e hoʻolauna a kūʻai aku ke kālā i nā kālā me nā ʻano like ʻole, mai ka 500 mg a 1000 mg. Aia kekahi mau lāʻau lapaʻau he hopena lōʻihi. Ua kuhikuhi ʻia ke ʻano lāʻau mua ma ka liʻiliʻi liʻiliʻi, ma hope o ke kau nei ke kauka e hoʻonui i loko. Hiki i ka nui o nā mea hoʻohana i kēlā me kēia lā ke hoʻoponopono ʻia e ke kauka, akā ʻo ka nui o nā lā i ʻae ʻia i kēlā me kēia lā, ʻaʻole iʻoi aku ma mua o g

He aha e hana me ka overdose o ka lāʻau

Mai hoʻonui i ka hopena o ka lāʻau lapaʻau e hoʻoikaika i ka hopena o ka lāʻau lapaʻau a wikiwiki paha i ka manawa hoʻōla. ʻO ka maʻamau, ua hoʻopau ka overdose i nā waimaka - e hōʻeha i ka nui o ka hōʻeha i ke kino, ʻaʻole maʻamau nā hihia hōʻeha.

ʻO ka pilikia o kahi overdose o Metformin ka hoʻomohalaʻana i ka acidosis lactic. ʻO nā hōʻailona ʻona o ka maʻi he ʻōpū (ʻo ia hoʻi, ma ka ʻōpū) a me ka ʻehaʻeha, ke pilikia ʻana o ka huina ʻana, nā ea wikiwiki, hoʻohaʻahaʻa i ke ʻano o ke kino, hōʻalo a me ka nalowale o ka ʻike ʻana i kahi ʻeho.

Inā liʻiliʻi ʻoe i kekahi o kēia mau hōʻailona, pono ʻoe e hoʻokaʻawale i ka lawe ʻana i ka lāʻau lapaʻau a hui koke i kahi kauka. E lawe ka haukapila i nā mea āpau a pau e wehe ai i ka lactate mai ke kino. I nā hihia koʻikoʻi nui, hoʻonoho ʻia nā hemodialysis. He ʻoi loa a hāʻawi i nā hopena wikiwiki.

Hoʻopili me nā lāʻau lapaʻau ʻē aʻe

He ʻano hiʻohiʻona ka deralative o biguanides - aneane pau ke ʻano o nā waiwai a pau ma ke kua, ʻaʻole loli, a ʻo ke koena (e pili ana i 10%) i hōʻiliʻili i ke kino. A inā hoʻomaka nā hana o nā pūlū, hiki ke hōʻuluʻulu ʻo Metformin i nā pūpū, a me nā hopena maikaʻi ʻole.

Lā ʻia ka hoʻohana ʻana i ka metformin me ka waiʻona

He mea nui hoʻi ia e hoʻoponopono pololei i ka hoʻohana ʻana i nā lawena hypoglycemic me ka insulin. Ma hope o nā mea a pau, inā ʻike ʻo Metformin i ke koko heʻoi aku ma mua o ka mea i manaʻo ʻia, hiki i ka mea maʻi me ka hoʻopuka ʻana i ka insulin e hiki i loko o kahi comog hypoglycemic ma muli o kahi emi o ka hōʻeha i ka glucose.

ʻO ka emi ʻana o ke kahe o ke koko e mālama ʻia ana me ka hoʻohana pū ʻia ʻana o kēia mau lāʻau me Metformin:

Ololi Holi,
Nā NSAID
luanuhauna
ʻO MAO inhibitors (papa antidepressants maʻamau),
acarbose,
ACE paleai
huoli
β-blockers

A ʻo kēia mau kālā, ʻoiai ke hoʻohana ʻia me ka lāʻau hoʻokaʻina gula, ma ke ʻano ʻē, e hōʻemi i kāna hana:

corticosteroids
ʻO nā hormones thyroid
hoʻoiho
estrogens
nā mea hoʻohālikelike waha
hoʻōla nicotinic
nā mea ʻokoʻa kaleka
adrenomimetics
isoniazids, etc.

No laila, ʻo Metformin kahi lāʻau lapaʻau maikaʻi-hoʻohaʻahaʻa maikaʻi i loaʻa ka hana kūpono, akā i ka manawa like ʻaʻole ia he ʻano maʻamau. Aia nā hopena maikaʻi ʻole a me nā contraindications. ʻO ka hapa nui o lākou ka mea liʻiliʻi a hele i loko o nā hebedoma 1-2, akā hiki i kekahi ke hoʻōki i ka lawe ʻana.

I ka mea e maikaʻi ai ka lāʻau lapaʻau, pono ia i ka hoʻonohonoho ʻana i ke ʻano me ke kauka, e hahai i kāna mau ʻōlelo hōʻike a pau, paʻa pono i ka meaʻai i kauoha ʻia a mālama pono ʻia nā contraindications a me nā hopena ʻaoʻao. Pono ʻoe e hoʻomanaʻo i ka waiʻona ka ʻikepili nui o Metformin, no laila pono ke hoʻokaʻawale ʻia nā mea inu wai inu i ka wā o ka mālama ʻana. ʻO kēia ke kumu o ka hakahaka o ka waiʻona i ka hana o kekahi nui o nā enzyme o ka ate. No laila, ʻo Metformin e komo i ke kahawai, kahi e piʻi ai i kahi emi o ka pae o ka glucose i ka hypoglycemia. Eia kekahi, waiʻona i ka wā e hoʻohālikelike ai i nā lāʻau lapaʻau ka hoʻopuka lactic acid. Pēlā, ʻo ke hoʻohana ʻana i ka wā o ka mālama ʻana me kēia lāʻau lapaʻau ua contraindicated.

ʻO ka hapa a me ke ala o ka hoʻokele lāʻau

ʻO ka lāʻau lapaʻau no ka diabetes mellitus "metformin" hiki ke lawe wale ʻia e ke kauka. Kauka ke kauka a kau i kahi kaila pono. Me ia, pono ʻoe e kāpae i nā kikoʻī āpau o ka lawe ʻana i ka lāʻau lapaʻau. ʻO nā ʻōlelo ākea e pili ana i ka lawe ʻana i ka metformin i ka mellitus maʻi diabetes:

ʻO ka papa kumu ma mua he 1 a 2 mau papa paha o ka lāʻau lapaʻau,
Inā ma hope o 2 mau hebedoma hopena i ʻike ʻia, hiki ke hoʻonui ʻia i ka hopena. Pehea ka nui o kēia hoʻonui e hoʻoholo i nā kauka. Aia ia i ka pae o glucose i loko o ke koko,
ʻO ka dosage maʻamau, ke kōkua nei i ka mālama ʻana i ke kō koko koko a pale aku i nā hōʻeha, ʻo 3 a me 4 mau papa i kēlā me kēia lā,
Inā ʻelemakule ka mea maʻi, ʻaʻole ia e inu i ka lāʻau lapaʻau ma loko o kahi eʻoi aku ma mua o 2 papa i kēlā me kēia lā,
ʻO ka nui loa ka wai e hiki ke inu ʻawa wale e like me ke kauka ʻana i kahi kauka he 6 papa i kēlā me kēia lā.
Hiki iā wau ke inu i ka pākolo holoʻokoʻa i kēlā me kēia lā? Hoʻomaopopo nā kauka i ke hoʻokaʻawale ʻana i nā iniha i 3 dosa,
Pono ʻoe e inu i ka lāʻau lapaʻau ma hope koke o ka ʻai ʻana. I kēia hihia, e noʻonoʻo e inu i nā papa me ka nui o ka wai.

Me ka overdose, ʻike koke ʻia nā hopena āpau. E makaʻala, ʻoiai ʻo ka hōʻino ʻana o kēia lāʻau lapaʻau ke alakaʻi i nā hopena hōʻeha. Hoʻomaopopo ka lāʻau lapaʻau metformin no ka maʻi type 2 me ka pili pono i nā ʻōkuhi.

Mai poina e lawe i kahi papaʻai i ka manawa like me ka lawe ʻana i ka lāʻau lapaʻau a hana i nā hana ʻano maʻalahi. Ma waho o kēia mau ana, ʻaʻole pono kekahi lāʻau lapaʻau, a he hiki ʻole iā ʻoe ke pale aku i nā hopena koʻikoʻi.

E hoʻokuʻu i ke ʻano a me ka ʻano

ʻO nā papa coated Enteric, Metformin he ʻano hāmeʻe, kahi aniani o ka biconvex a me ke keʻokeʻo. ʻO ka mea hana nui o ka lāʻau lapaʻau ka metformin hydrochloride, ʻo kona ʻike i loko o hoʻokahi papa he 500 mg. Eia kekahi, ʻo kāna mea hoʻohui e komo i nā mea kōkua, i loaʻa i kēia:

Kūʻaiole.
Talii.
ʻO ka lāʻau ʻo Magnesium.
ʻ stlelo ʻehala.
Ka waikawa Methacrylic a me nā methyl methacrylate copolymer.
Povidone K90.
Kaapili Titanium
Macrogol 6000.

Hoʻopili ʻia nā papa metformin i loko o kahi pūʻulu blister o 10 mau ʻāpana. Aia ka pahu kīleʻa he 3 blisters (30 mau papa) a me kahi palapala no ka hoʻohana o ka lāʻau.

Ka hana lāʻau lapaʻau

ʻO ka hana ikaika o nā papa Metformin e hōʻemi i ka kaila o ka glucose i ke koko ma muli o kekahi mau hopena ola.

Hoʻemi ka hoʻoliʻi ʻana o ka glucose mai ke kinipona palani i loko o ke koko.
ʻO ka hoʻonui ʻana i ka hoʻowalewale o ka ʻenehana receptors i ka insulin (he pancreatic hormone e hoʻonui ai i ka hoʻohana ʻana o ka glucose mai ke koko i loko o nā kiko o ke kino).
Hoʻopili i ka hoʻohana pono ʻana i ka peripheral kalehu i nā kōpau o ke kino.

ʻAʻole pā ka Metformin i nā peka pancreatic i kuleana no ka synthesis o ka insulin, ʻaʻole ia e hoʻopilikia i kona pae i ke koko, a ʻaʻole hoʻi ke alakaʻi i nā kūlana hypoglycemic (kahi mākaʻikaʻi i hōʻailona i ka hoʻoliʻi o ka glucose i loko o ke koko). Hoʻemi i ka pae o ka triglycerides (nā momona i ke koko), kōkua i ka hoʻomaikaʻi i ka metabolism i loko o ke kino, alakaʻi i ka lilo kaumaha, loaʻa ka hopena fibrinolytic (kōkua hoʻopau i nā fibrin).

Ma hope o ka lawe ʻana i nā papa Metformin i loko, ʻaʻole e hoʻopihapiha i ka mea ikaika (ʻoiʻo bioavailability e pili me 60%). Ua hoʻokaʻawale pinepine ʻia ma ke kōpona o ke kino, ʻiliʻili nui i nā kelima salima, ʻāʻī, nā pēpē a me nā naʻau. Ka hoʻolaʻaʻana o ka mana ikaika o ka lāʻau i ka loli a hoʻokaʻawale ʻia i ka urine. ʻO ka hapalua-ola (ʻo ka manawa o ka hapalua o ka nui o ka nui o ka lāʻau ua hōʻiho ʻia mai ke kino) ʻo 9-12 mau hola.

ʻLoe a me ke kākele

Lawe ʻia nā papa metformin me ka meaʻai me ka meaʻai a i ka manawa koke o ka lawe ʻana. Mai kuke i ka papa ʻai a inu i ka wai he nui. No ka hōʻemi i ka hiki ke hoʻomohala ʻana i nā hopena ʻino mai ka ʻōnaehana ʻana, e lawe ʻia ka nui o ka lā i kēlā me kēia lā, hoʻokaʻawale iā 2-3 mau ōka. Kauka ke kauka i ka maʻa a me ka regimen o ka lāʻau lapaʻau kūʻokoʻa, e pili ana i ka hoʻomaka mua o ke kō i loko o ke koko, a me ka pono o ka therapeutic efficacy. ʻO ka maʻamau, ʻo ka dosis hoʻomaka e 500-1000 mg i kēlā me kēia lā (1-2 papa). Ma hope o nā lā he 10-15, e kau ana i ka pae o ka hoʻoliʻiliʻi o ka glucose i ke koko, e hiki ke hoʻonui i ka nui o ka ʻai ʻana o nā papa Metformin i 1500-2000 mg i kēlā me kēia lā. Pono e hoʻonui ka nui o ka lā ma kēlā me kēia lā iā 3000 mg. I nā poʻe kahiko, ʻaʻole pono ka nui o ka lapaʻau therapeutic o kēlā me kēia lā ma mua o 1000 mg.

Nā hopena hopena

ʻO ka lawe ʻana i nā papa metformin hiki ke alakaʻi i ka hoʻopuka ʻana o ka hopena ʻaoʻao mai nā ʻokoʻa āpau a me nā ʻōnaehana:

Pūnaehana Digestive - ka ʻono "metallic" i loko o ka waha, ka ʻuwelu, ka luaʻi manawa, ka ʻōpū o ka ʻōpū, ke ʻōpala, ka make ʻana o ka makemake a hiki i kona pau ʻole (anorexia), lemulence (hoʻonui i ka hoʻomohala hau i loko o ka ʻōpū o ka ʻōpū). Kēia mau hopena like ʻole e ulu i ka hoʻomaka o ka papa o ka mālama ʻana me ka lāʻau lapaʻau a nalo i kā lākou iho. No ka hōʻemi i ka nui o kēia mau maʻi i ka wā e hiki ai, nā antacids, antispasmodics a me nā mea nui e like me ka atropine e like me ke kauka komo ʻana.
ʻO ka ʻōnaehana endocrine he hypoglycemia (kahi awe i ke kaohi koko kō ma lalo o ka maʻamau).
Metabolism - lactic acidosis (hoʻonui i ka lactic acid i loko o ke koko), hoʻopiʻi ʻana i ka hoʻōla o ka vitamin B12 mai ka ʻawaʻawa.
I loko o ka ʻōpū a me ka iwi ʻulaʻula - megaloblastic anemia (anemia e pili ana i ka hoʻokūkū o ka hoʻokumu a me ka hoʻokaʻina o nā ʻona koko wīwī i loko o ka ʻōpū o ka iwi ʻeha ma muli o ka lawa ʻole o ka ʻai o ka huaola B12) hiki ʻole paha i ka ulu hoʻomohala.
Allergic reaksi - ke ʻohi o ka ʻili a me ka ʻeha.

Me ka hoʻomohala ʻana o nā hopena ʻaoʻao ma hope o ka lawe ʻana i nā papa Metformin, ua hoʻoholo ke kauka i ka hōʻoki ʻana i nā lāʻau lapaʻau ʻokoʻa, e pili ana i kā lākou ʻano a me ka paʻakikī.

Nā ʻōlelo kikoʻī

Ma mua o ka lawe ʻana i nā papa Metformin, pono ʻoe e heluhelu pono i nā ʻōkuhi no ka lāʻau lapaʻau. Nui kekahi mau ʻōlelo kikoʻī e pili ana i kona hoʻohana ʻana, ʻo ia hoʻi:

Me ka ʻike o ka mau ʻana o ka ʻehaʻelima (myalgia) ma hope o ka hoʻomaka ʻana o ka lāʻau lapaʻau, hoʻoholo ʻia kahi kāpili o ka pae o ka lactic acid i ke koko.
Pono ka hoʻohana ʻana o ka lāʻau i ka wā lōʻihi e nānā ai i nā ʻōmaʻomaʻo o ka hana ʻōnaehana o ka hana hana a nā keiki.
Me ka hoʻohana pū ʻana o nā papa Metformin me nā lāʻau lapaʻau i loaʻa mai ka sulfonylureas, e pono ai ka nānā ʻana o ka mālama manawa maʻamau i nā pae glucose o ke koko.
I ka wā o ka mālama ʻana e pono ai e pale i ka inu ʻana i ka waiʻona a me nā lāʻau lapaʻau e pili ana i ka ethanol.
Hiki i nā papa metformin ke hoʻopili me nā lāʻau lapaʻau o nā lāʻau lapaʻau ʻē aʻe, no laila, i ka wā e lawe ai iā ia, pono ia e ao i ke kauka e pili ana i kēia mea.
Inā ʻike nā hōʻailona o ka bronchopulmonary a me genitourinary pathology ma ke kua o ka lawe ʻana i ka lāʻau lapaʻau, pono e hoʻōna ʻia kona hoʻohana a kūkā me ke kauka.
ʻAʻole pili koke ka lāʻau lapaʻau i ka hana hana o ka cortex cerebral, akā naʻe, i ka wā e hoʻohana pū me nā lawena hypoglycemic ʻē aʻe, piʻi ka hopena o ka hypoglycemia, no laila ke hana ʻana i nā hana e pili ana i ka pono o ka piʻi ʻana o ka nānā a me ka wikiwiki o ka hopena psychomotor, pono e hoʻomaʻamaʻa.

I loko o ka pūnaewele kūʻai lapaʻau, loaʻa i nā papa Metformin ma ke kau inoa. ʻAʻole kuhikuhi ʻia ka hoʻokele ʻana me ka manaʻo ʻole pono ʻole.

Ke keu

Me ka nui o ka nui o ka lāʻau therapeutic i ʻōlelo ʻia i nā papa Metformin, ʻo ke kahe o ka waikika lactic i ke koko (piʻi i ka lactic acidosis). Hoʻopili ʻia kēia me ka nausea, ka luaʻi, ka ʻōpū, ke emi ʻana o ke ʻano kino o ke kino, ka ʻeha i ka ʻōpū a me ka ʻōpū, a me ka wikiwiki. I kēia hihia, pono e hoʻoneʻe ʻia ka lāʻau lapaʻau. Lawe ʻia ka maʻi overdose i loko o ka haukapila me ke kōkua o hemodialysis (hoʻomaʻemaʻe i nā ʻoihana koko).