Minirin® (Minirin)

Nā palapala kiko o Minirin:

• Nā papa 100 mcg: keokeo, ka oval, ke kalapula, me ka ʻōlelo "0.1" ma kekahi ʻaoʻao a me ka ʻekeʻala ma kekahi (30 mau polu.
• Nā papa 200 mcg: keokeo, pōʻai, convex, me ke ʻano "0.2" ma kekahi ʻaoʻao a me ka ʻikena ma kekahi (30 mau p. Ma loko o kahi haki wai, i loko o kahi pahu pahu, 1 pahu).
• Nā papa pālaha 60 mcg: keʻokeʻo, pōʻai, kāpili ʻia ma ka ʻaoʻao hoʻokahi me kahi puna (10 pcs. Ma kahi kīwaha, i loko o ka pūlima kāleka o 1, 3 a i ʻole 10 mau laha).
• Nā papa pālaha 120 mcg: keʻokeʻo, pōkole, hōʻailona ʻia ma ka ʻaoʻao hoʻokahi me nā pahu he ʻelua (10 mau p. I loko o kahi kīwī, i loko o ka pūlima kāleka o 1, 3 a i ʻole 10 mau laha).
• Nā papa pālaha, 240 mcg: keʻokeʻo, pōkole, kāpili ʻia ma ka ʻaoʻao hoʻokahi i ke ʻano o nā hehi ʻekolu (10 mau p. I loko o kahi kīwī, i loko o kahi pūpū kāleka o 1, 3 a i ʻole 10 mau laha).
• ʻO ka pāʻina no ka hoʻohana ʻana i ka ihu (2.5 a i 5 ml paha kēlā me kēia i loko o kahi pahu aniani i piha kahi me ka mea noi mea nasal, i loko o kahi pahu pahu o 1 set).

ʻO ka mea kūpono a desmopressin acetate, pili ka mea i kau i ke ʻano o ka hoʻokuʻu ʻana:

• Nā papahele: i ka ʻāpana 1 - 100 a i 200 gg (ma kēlā me kēia he 89 a 178 μg o desmopressin),
• Nā papa Sublingual: ma ka ʻāpana 1 - 67, 135 a 270 mcg (60, 120 a i ʻole 240 mcg o ka desmopressin, i kēlā me kēia),
• ʻOhi: i ka 1 ml (10 mauʻu) - 100 mcg.

• Nā papahele: stearate magnesium, povidone, starch potato, lactose,
• Nā papa Sublingual: waikawa citric, mannitol, gelatin,
• Mīwī: benzalkonium chloride, sodium hydrogen phosphate dihydrate, sodium chloride, citric acid (monxidate), ka wai maʻemaʻe.

Nā hōʻailona no ka hoʻohana ʻana

• ʻO ka maʻi maʻi maʻi indipidus o ke kumu kumu,
• Nocturia (nocturnal polyuria) i nā pākeke ma ke ʻano he maʻi maʻi
• ʻO nā moʻomeheu mua ma mua o nā keiki he 6 mau makahiki.

Eia kekahi, ua hoʻokaʻawale ʻia ka pīpī no ka hoʻohana ʻana ma ka mālama ʻana i ka polydipsia pōkole a me polyuria ma hope o nā hana i loko o ka gland pituitary, a ma ke ʻano he hana diagnostic e hoʻokū ai i ka hiki ke paʻa o nā kolo.

Nā Hoʻohui

• ʻO ka hemahema o ka puʻuwai a me nā kūlana ʻē aʻe e pono ai ka lawelawe ʻana o ka diuretics,
• ʻO ka polydipsia kaulana a i ʻole ka psychogenic (me ka nui o ka urine o 40 ml / kg / lā),
• Hyponatremia,
• ʻO ka Syndrome o ka hana hikiʻole ke hana o ka hormone antidiuretic (ADH),
• Hōʻino nā hōkuhi a me ke koʻikoʻi o ka maʻi hana (cleanine clearance

ʻLoe a me ke kākele

Lawe ʻia nā papa ʻelua i kekahi manawa ma hope o ka ʻai ʻana, no ka mea e hoʻolōʻihi i ka ʻai me ka hoʻēmi i kona hopena.

Hoʻohana ʻia nā papa Sublingual i kahi sublingally (hoʻohuihui ʻia ma lalo o ka alelo), ʻaʻole holoi ʻia me ka wai me ka wai!

Nā ʻōlelo hoʻohālikelike ma waena o nā ʻano waha ʻelua o Minirin penei: nā papa pili sublingual o 60 a me 120 μg e pili ana i nā papa o 100 a me 200 μg. Pono ke koho ponoʻī o ka lāʻau ola pono loa.

Ua hōʻike ʻia ka hoʻoponopono ʻia no ka papa sublingual:

• Insipidus kikowaena waena. ʻO ka maʻa mua loa he 60 mcg 3 mau manawa i ka lā, i ka wā e hiki mai ana ke hoʻoponopono ʻia e pili ana i ka hopena o ka lāʻau lapaʻau. Hiki i ka hopena o kēlā me kēia lā mai ka 120 a hiki i 720 mcg, ka nui ka mālama mālama pono ʻana no ka hapa nui o nā maʻi he 60-120 mcg mau manawa 3 i ka lā,
• Enuresis papa kikoʻī. ʻO ka dosis mua loa he 120 mcg, lawe ʻia hoʻokahi manawa i ka pō, me ka loaʻa ʻole o ka maʻi lapaʻau, ʻae ʻia ka hapalua a hiki i ka 240 mcg e ʻae ʻia, i ke ahiahi ua ʻōlelo ʻia e ka mea maʻi e kaupalena i ka inu ʻana i ka wai. Ma hope o 3 mau mahina o ka hoʻomau mau nei o ka mālama ʻana, ua hoʻoholo ka hoʻoholo e hoʻomau i ka lawe ʻana i ka lāʻau lapaʻau ma luna o ke ʻano o nā hōʻike i mālama ʻia no 7 mau lā ma hope o kona haʻalele ʻia ʻana.
• ʻO ka polyuria Nocturnal i nā pākeke. ʻO ka initanika mua loa he 60 mcg i ka pō, i ka hala o ka hopena i makemake ʻia i loko o ka hebedoma 1, e hoʻonui ʻia ka lāʻau i ka 120 mcg, a laila pono, inā pono, i ka 240 mcg (me ka piʻi o ka pule ma kēlā me kēia pule). Pono e mālama i ka hoʻoweliweli o ka noho o ka hoʻomaha ma ke kino. Inā ma hope o 4 hebedoma, i mālama ʻia ai ka hoʻoponopono ʻana, ʻaʻole hiki ke hoʻokō i ka hopena lapaʻau i kali ʻia, ʻaʻole pono ka hoʻohana hou ʻana i ka lāʻau.

Hoʻohana ʻia ka minirin spray me ka intranasally, ka palena o ka hāʻule me ka pohihihi māmā o ka dropper, ʻo ia kahi o ka pani o ka hue. Ke hoʻokō nei i ka lāʻau lapaʻau, pono ka mea maʻi ma ke kūlana "noho" a "waha ʻole", me ke poʻo o ka poʻo. Hāʻawi ʻia nā pākeke i nā lā he 10-40 mcg i nā lā (1-4 mau i nā wai he 2-4), no nā keiki mai 3 mau mahina a hiki i 12 mau makahiki - 5-30 mcg. No ka mālamaʻana i ka enuresis primale nocturnal, mālama ʻia ka lāʻau lapaʻau i ka manawa e moe ai i kahi ma mua o 20 mcg, inā ʻaʻole maikaʻi loa ka lāʻau lapaʻau, ʻae ʻia ka piʻi a hiki i ka 40 mcg, ma hope o 3 mau mahina o ka lapaʻau, lawe ʻia ka hoʻōla pule ma ka wiki e loiloi i nā hopena hopena.

Nā hopena hopena

Ke hoʻohana nei iā Minirin, ulu pinepine nā hopena i loko o kēlā mau hihia i ka wā e hoʻokō ʻia ai ka lāʻau me ka ʻole o ka palena o ka hoʻowalewale ʻana, e pili ana i nā ʻano o ka hyponatremia a me / a i ʻole ka hoʻomaha ʻia o ka wai. Hiki i kēia mau pilikia ke asymptomatic a hele pū me nā mea i ʻike i lalo:

• Pūnaehana maʻi: hōʻeha, ka ʻeha, ma nā hihia koʻikoʻi - cramps,
• Pūnaehana Digestive: nausea, waha maloʻo, luaʻi,
• ʻO nā mea'ē aʻe: loaʻa ka uku, ke edema peripheral.

ʻO ka hoʻohui no ka pā:

• Pūnaehana lawelawe: ka huehue o ka mucosa nasal, rhinitis,
• Pūnaehana Cardiovascular: ke hoʻonui hōʻemi i ke kahe o ke koko (i ka wa i hoʻohana ʻia ai i nā helu kiʻekiʻe)
• Kūpono o ka ʻike: conjunctivitis, nā lacrimation maʻi.

I ka hihia o ka overdose, hoʻonui i ka lōʻihi o Minirin, piʻi ka nui o ka hyponatremia a me ka mālamaʻana o ka wai. I kēia kūlana, pono ʻoe e hoʻokaʻawale i ka hoʻohana ʻana i ka lāʻau lapaʻau, haʻalele i nā mea i hoʻohiolo ʻia ma ka intake intake a ʻōlelo i kahi loea. Inā pono, hiki i ka hoʻopili i kahi hopena hypertonic a isotonic sodium chloride, a me ke ke ʻano o ka furosemide (me ka hoʻomohala ʻana o nā kau, a me ka nalowale o ka ʻike).

Nā ʻōlelo kikoʻī

Me nā enuresis nocturnal primer, kahi kauoha o ke kau ʻana i ka wai o ka holo i ka palena he 1 mau hola ma mua a i loko o 8 mau hola ma hope o ka lawe ʻana i ka lāʻau. A i ʻole, he piʻi aʻe ka paʻakikī o ke kūkulu ʻana i ka hopena makemake ʻole.

I ka wā o ka papa hana, pono ia e nānā pono i ke kūlana o ka poʻe kahiko, nā keiki a me nā wā'ōpiopio, nā mea maʻi me nā hoʻoweliweli no ka piʻi ʻana o ka naʻau intracranial a i ʻole ka wai kīnā ʻole a me / a me nā kaulike electrolyte.

Ma ka hoʻokaʻina ʻana o Minirin i ka poʻe maʻi ma mua, ma mua o ka hoʻomaka ʻana o ka papa, 3 mau lā ma hope o ka noi mua a ma ka ulu ʻana o kēlā me kēia mimi, pono ia e nānā i ke ʻano o ka mea maʻi, me ka hoʻoholo pū ʻana i ka paʻakai o ka sodium i ka plasma koko.

Ma ka hihia o ka hoʻokele intranasal o ka lāʻau, ʻo ka hiki ʻana o ka rhinitis koʻikoʻi a me ke kaʻa ʻana o ka mucosa nasal hiki ke alakaʻi aku i kahi kīnā o ka desmopressin, ma muli o ke ʻano e hāʻawi ʻia ai ka lawelawe waha ʻana i kēlā mau hihia.

Ke hoʻohana nei ʻo Minirin ma ke ʻano he diagnostic mea, ʻaʻole pono ke hoʻokō ʻia ka hoʻohaʻomaʻi ikaika (ʻoiai ʻole a makua paha), pono e lawe ka mea maʻi e like me ka mea e pono ai e hoʻopau i ka makewai.

Pono ka hana o ka lāʻau lapaʻau i ka noiʻi ʻana i ka hiki o ka paʻa o nā ʻōpū i nā keiki ma lalo o 1 makahiki mau makahiki e pono ai ke lawe wale ʻia i kahi haukapila.

Me ka decompensated diabetes mellitus a me polydipsia, me ke ʻano o ka dysuria a me / a nocturia, incontinence urinary acute, maʻi urinary infection, hopohopo i ke ʻano o ka prostate glandder a i ʻole ke kala ʻana, ka maʻi a me ka mālama ʻana i kēia mau maʻi a me nā kūlana e pono e mālama ʻia ma mua o ka hoʻomaka ʻana me ka Minirin.

Pono ia e kāpae i ka lawe ʻana i ka lāʻau lapaʻau inā inā he fiva, gastroenteritis, nā maʻi kūlohelohe i ka wā mālama.

Hoʻohui nūhou

E noʻonoʻo e inā hui pū me Minirin:

• Indomethacin - hoʻonui i ka hana o ka lāʻau lapaʻau,
• Tetracycline, glibutide, norepinephrine, lithium - hoʻemi i ka hana antidiuretic,
• ʻO nā inhibitor serotonin koho, antidepressants tricyclic, carbamazepine, chlorpromazine - hiki ke alakaʻi i kahi hopena antidiuretic aditif a hoʻonui i ka hopena o ka hoʻopaʻa ʻana a me ka hyponatremia,
• ʻO nā lāʻau anti-inflammatory nonsteroidal - hoʻonui i ka nui o ka hopena o nā hopena,
• Dimethicone - kōkua ia e hōʻemi i ka lawe ʻana o ka desmopressin.

Ke hui pū ʻo Minirin me ka loperamide, hiki ke ʻike ʻia kahi ʻekolu o ka nui o ka paʻa o ka desmopressin i loko o ka plasma, e hoʻonui nui ana i ka maʻi o ka noho ʻana o ka wai a me ka hopena o ka hyponatremia. Aia aia kahi kūpono e hiki ai i nā lāʻauʻokoʻa ke hoʻolōʻihi i ka peristalsis hiki i kahi hopena like. I ka hihia o ka hoʻohana like ʻana me nā lāʻau lapa i luna, e koi ʻia ka nānā ʻana i ka pae o ka sodium i loko o ka kō koko.

Nosological ʻano papa (ICD-10)

Pharmacological waiwai o ka lāʻau Minirin

Aia nā papa ʻaina Minirin i ka desmopressin - kahi analogue synthetic o ka hormone maoli o ka gland pituitary posterior - arginine-vasopressin (antidiuretic hormone). Loaʻa ka Desmopressin ma muli o nā loli i ka ʻōnaehana o ka vasopressin molekui: deamination o 1-cysteine ​​a me ka hoʻololi o 8-L-arginine me 8-D-arginine.
Hoʻohālikelike me ka vasopressin, hiki i ka desmopressin ka hopena i hiki ke hoʻoneʻe i nā io polu o nā kaila koko me ka hana antidiuretic i haʻi ʻia. Ma muli o nā loli loli i wehewehe ʻia, hoʻōla wale ʻo Minirin i nā ʻenehana komo vasopressin V2 e loaʻa ana i ka epithelium o nā pālule convoluted a me kahi ʻāpana o ka piʻo Henle e piʻi ana, kahi e hoʻonui ai i nā pali i nā sela epithelial nephron a alakaʻi i ka hoʻonui hou ʻana o ka wai i loko o ke kahe wai. Ma hope o ka lawe ʻana i ka lāʻau lapaʻau, loaʻa ka hopena antidiuretic i loko o 15 mau minuke. Hāʻawi ka 0.1-0.2 mg o ka desmopressin i ka hopena antidiuretic ma ka hapa o nā poʻe maʻi a hiki i nā hola 8-12. A ke kumu, ua emi mai ke alapine a me ka paʻakikī o ka nocturia.
ʻAʻole maopopo i ka hopena teratogenic a i ʻole mutagenic desmopressin.
Hoʻomaka ka Desmopressin e ʻike ʻia i ke koko 15-30 mau minuke ma hope o ka hoʻokele ʻana. Loaʻa ka uka nui o ka plasma koko ma hope o nā hola 2. ʻO ka hapalua o ka desmopressin i loko o ke kaila koko he 1.5–3.5 mau hola.

Ka hoʻohana ʻana o ka lāʻau Minirin

E hoʻohana i ka lāʻau lapaʻau wale nō e like me ka kauka ʻana o kāu kauka. Kahi ʻia ka hopena palekana o ka lāʻau i kēlā me kēia.
Hāpai mau maʻi maʻi insipidus. ^ E Ha yM. ʻO ka ʻōmua mua no nā pākeke a me nā keiki ma mua o 5 mau makahiki he 0.1 mg o ka desmopressin 3 mau manawa i ka lā. Koho ʻia kahi ʻōmole ʻē aʻe ma muli o ka hopena o ka mea maʻi. Wahi a nā hualoaʻa o ka maʻi noʻonoʻo, ka ʻokoʻa o ka lā o kēlā me kēia lā he 0.2 a 1.2 mg o desmopressin. No ka hapanui o nā maʻi, ʻoi aku ka maikaʻi o ka lawe ʻana i 0.1-0.2 mg o ka desmopressin 3 mau manawa i ka lā.
Enuresis papa kikoʻī. ^ E Ha yM. ʻO ka ʻōmua mua no nā pākeke a me nā keiki ma mua o 5 mau makahiki ka lawe i ka 0.1 mg o ka desmopressin i ka pō holo wale. I ka hihia o ka hopena, hiki ke hoʻonui i ka nui i ka 0.4 mg. ʻO ka papa hana o ka mālamaʻana he 3 mau mahina. ʻO ka nīnau o ka pono e hoʻomau i ka ʻoihana e hoʻoholo ma hope o ka hopena o ka hebedoma i ka wā e lawe ai iā Minirin. I ka wā hana, pono ʻoe e kaupalena i ka inu ʻana i ka wai i ka pō a ma hope o ka lawe ʻana i ka lāʻau lapaʻau.
Nocturia (nocturnal polyuria). ʻO ka ʻōmai mua i ʻōlelo ʻia no nā pākeke a me nā keiki ma mua o 5 mau makahiki he 0.1 mg i ka pō. Ma ka hihia o ka hoʻopiʻi ʻana i ka hopena mua no ka wiki 1, e hoʻonui pinepine ka nui i ka hebedoma i 0.2 mg a ma hope iho i 0.4 mg. Pono ʻoe e ʻike i ka noho paʻa ʻana ma ke kino. I nā mea maʻi 65 mau makahiki a ʻoi aku ka nui, pono e nānā ʻia ka pae o ka sodium i ke koko ma mua o ka mālama ʻana, ma hope o 3 mau kaha o ka lāʻau lapaʻau a ma hope o ka hoʻonui ʻana i ka nui.
I ka hopena o nā hōʻailona o ka hoʻokipa o ka wai a me / a i ʻole hyponatremia (ke poʻo, ka hōʻilo, ka luaʻi ʻana, ka loaʻa ʻana o ka paona, i loko o nā hihia koʻikoʻi - nā kīwaha), pono e hooki ʻia ka mālama ʻana a hiki i ka hoʻōla hou ʻia ka mea maʻi. Ke hoʻoiho nei i ka mālama ʻana, pono e nānā pono kekahi i ka kaohi ʻana o ka inu kahe e ka mea maʻi.

Nā lāʻau lapaʻau lāʻau Minirin

Hiki i Indomethacin ke hoʻonui i ka hopena o Minirin me ka hoʻonui ʻole i ka lōʻihi o kāna hana. ʻO nā mea i kumu e hoʻonui ai i ka hoʻololi o ka hormone antidiuretic (vasopressin), kekahi mau ʻano antidepressants (chlorpromazine a me carbamazepine) hiki ke hoʻonui i ka hopena antidiuretic o Minirin a hoʻonui i ka pilikia o ka hoʻopiʻi nui ʻana i ka wai ma loko o ke kino.

ʻO ka overdose o ka lāʻau Minirin, nā hōʻailona a me nā mālama

Me kahi overdose, nui ka pilikia o ka hyponatremia a me ka mālama ʻana i ka wai ma ke kino. ʻOiai pono ke kūlike ka mālama ʻana o ka hyponatremia, aia nā manaʻo nui:

• ma ka hihia o ka hyponatremia asymptomatic, ʻaʻole pono e hōʻino ʻia ka lawelawe ʻana o Minirin a no laila e kaupalena ʻia ka mea maʻi i ka inu ʻana,
• inā e hōʻike ʻia nā hopena i manaʻo ʻia e ka hyponatremia, kahi hana ʻōkuhi holomua o iso-or hypertonic sodium chloride solution.
• i nā hihia koʻikoʻi, mālama ka noho i loko o ke kino, i hōʻike ʻia e nā mea hoʻokūkū a me / a i ʻole ka nalowale o ka ʻike ʻana, pono e hoʻopili i ka paʻakikī (hōʻailona) i loko o ka hoʻoulu ʻana o ka furosemide.

ʻO ka weheweheʻana i ka lāʻau lapaʻau ma ka lāʻau

ʻO ka hopena nui o kēia lāʻau lapaʻau ka antidiuretic.

ʻO nā hana koʻikoʻi ʻē aʻe o ka lāʻau lapaʻau e loaʻa i:

1. Hiki ke alakaʻi i ke kaʻina o ke kōkoʻa koko. Hoʻōla ka lāʻau lapaʻau i ka mea VIII o kēia kaʻina hana. He mea koʻikoʻi kēia no nā poʻe me ka maʻi hemophilia a i ʻole von Willebrand,
2. Ke kū ka luna o ka mea hoʻonāne
3. ʻAʻole e like me nā lāʻau lapaʻau ʻē aʻe, e hana ʻoluʻolu ke hōʻoluʻolu i nā mea ʻalohina. ʻO ka hopena maʻalahi mau i nā iwi āpau,

ʻO ka hopena antidiuretic ma hope o ka lawe ʻana i ka lāʻau lapaʻau ma ke ʻano o nā hina nasal a i ʻole nā ​​papa i hoʻomaka i loko o hoʻokahi hola. E hoʻomaka ka hopena antihemorrhagic ma hope o ka hoʻokō ʻana i loko o nā minuke 15-30. ʻO ka hopena antidiuretic ka lōʻihi e kau wale i ka hola 1-5 ma hope o ka hoʻokele nasal a i ʻole 4-7 mau hola ma hope o ka lawe ʻana i nā papa.

E hoʻomau ka hana inā ke hoʻohana ʻana i nā hāʻule no nā hola 8-20. Inā lawe ʻia ka lāʻau lapaʻau ma ke ʻano o nā papa, a laila e hāʻawi ka nui o kahi 0.1-0.2 mg i ka hopena ʻewalu hora, a me 0.4 mg - kahi hopena no nā hola he ʻumikumamālua.

Nā hōʻailona nui no ka hoʻohana ʻana

ʻO ka mea mua, ua kuhikuhi ʻia nā lāʻau lapaʻau no ka maʻi maʻi, a laila no ka mālama ʻana i ka maʻi diabetes o ka puka kumu (ʻo ke ʻano o ka maʻi maʻamau). Kōkua hoʻi ʻo Minirin inā he mau mea hōʻeha o nā genesis kikowaena, nā maʻi ʻē aʻe o ka lolo. Ua hōʻike ʻia ka lāʻau lapaʻau e like me ka mea e lawelawe ana i ka wā e hana ana i ka limuitary gland a me nā wahi i pili ia ia.

Hoʻomaʻamaʻa pinepine ʻo Minirin no nā hōʻailona mua o ka incontinence urinary, i hoʻoholo pū ai nō hoʻi i ka hiki ke kūpono o nā pūpū e nānā. He mea kūpono hoʻi ia e hoʻohui i ka maʻi hemophilia A a me von Willebrand (koe wale nō ke ʻano IIb) i ka papa inoa.

Nā hiʻohiʻona o ka hoʻohana a me nā contraindications

ʻO ka heleʻana o ka hypersensitivity i ka mea hana ka maʻi maʻamau. Pono e hoʻomanaʻo ʻia me ka polydipsia congenital a i ʻole psychogenic. ʻAʻole pono ka lawe i ka lāʻau lapaʻau i ka wā e hoʻokomo ai i ka lāʻau diuretic.ʻO ka poʻe e predisposed i ka hoʻokumuʻana o ka trombosis e pono hoʻi e haʻalele iā Minirin.

Hiki ke hoʻohui ʻia i ka angina hiki ʻole a me ke alo o von Willebrand maʻi type IIb i kēia papa inoa. Aia kekahi mau hiʻohiʻona o ka hoʻohana ʻana i ka hāʻule - he maʻi ʻohiʻoki a me ka ihu pupuni, ka hiki ʻana o nā maʻi o ka ʻōpū o ke kaʻa ʻana a i ʻole ke komo ʻana paha i ka mucosa nasal. He mea kūpono hoʻi e hoʻohui i ka nalo ʻana o nā ʻike a me nā kūlana postoperative.

He mea nui kēia! Pono e mālama ʻia ka minirin i nā poʻe me ka nele ʻole ʻole, a me ka fibrosis bladder. ʻAʻole no ke kau ʻia ʻana o nā keiki ma lalo iho o hoʻokahi makahiki a i ʻole nā ​​mākua. Pono e makaʻala ʻē a i ʻole nā ​​kānaka e ʻehaʻī i kahi piʻi kiʻekiʻe i loko o ke kaomi intacranial. Eia kekahi, me ka makaʻala, pono e hoʻohana ʻia kēia lāʻau lapaʻau e ka poʻe maʻi maʻi me ka pale ʻole i ka pae wai-electrolyte.

ʻO nā hopena ʻaoʻao:

• ʻO ka hele nui o ka ʻeha ma ke poʻo,
• ʻAʻohe mākaukau ʻole o ka hue
• ʻO ka ihu o runny, a me ka nosebleeds ma muli o ke hoʻonui ʻana i ke koko,
• ʻO ka pahuhopu Tachycardia,
• ʻO nā paona keu, ka mea i hele pū me ka ʻūlū ʻana o ke kino.
• ʻO ka paleʻana o ka maka, hiki i ka conjunctivitis,
• ʻAlaʻi o ka ʻili,
• Nā hōʻailona like ʻole o nā mālamalama,

ʻO kahi overdose o ka lāʻau lapaʻau e alakaʻi i ka make wai i loko o ka wai, e hoʻohewa ʻia. Hiki ke ʻike ʻia nā hōʻailona o ka neurological a me nā noʻonoʻo. Ma ke ʻano he mālama la, ʻoi aku ka maikaʻi o ka hoʻohana ʻana i ka haʻalele o ka lāʻau lapaʻau.

I kahi hihia o ka overdose, pono ia e hāʻawi i ke kino me ka loaʻa o ka nui o ka mea o ka wai o ka wai, pono ia e lūlū e hoʻolōʻihi i nā hopena paʻakai.

Pehea e lawe ai iā Minirin?

ʻO ka awelika maʻamau no ka pākahi he hoʻokahi i hāʻule i hoʻokahi mau manawa i ka lā. Aia ka nui o ka lāʻau lapaʻau ma waena o 10-40 mcg i hoʻokahi lā. Inā mai nā keiki mai 3 mau mahina a hiki i 12 mau makahiki (hiki ke hoʻohana ʻia ka lāʻau lapaʻau, akā me ka nui o ka makaʻala), a laila pono ke ʻano he 20 mcg i ka wā hiamoe (i kuhikuhi ʻia no ka bedwetting).

Pono ke kau no ka mālama ʻana i hoʻokahi pule, a laila hoʻihoʻi ma hope o ʻekolu mau mahina.

ʻOi aku ka maikaʻi o ka hoʻomākaukau ʻana no ka hana waha ʻana a me ka noho liʻiliʻi. I kēia hihia, pono e hoʻolei i kou poʻo i hiki ke loaʻa ka lāʻau lapaʻau ma kahi o kāna keʻena. Hiki i kahi ala kūpono ke hoʻokuʻu iā ia ke hoʻoponopono maʻalahi i ka helu o ka hāʻule. No ka hoʻoholo ʻana i ka hiki ke paʻa o nā pūpū, kuhikuhi ʻia ka lāʻau lapaʻau no nā keiki o 10 mcg.

ʻAʻole loa eʻoi aku ka palena loa loa ma ka 50 mcg. ʻO ka palena liʻiliʻi loa no kahi pākeke he 20 mcg. Ma hope o ka lawelawe ʻana i ka lāʻau lapaʻau, pono ʻoe e hele i loko o ka lua i ka wai i ka mea ʻalaʻawa no kekahi manawa, e hoʻāʻo e inu i nā wai (ʻehā mau hola ʻehā, akā ʻoi aku ka maikaʻi ke hoʻomaka ka inu ʻana ma hope o ʻewalu mau hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau).

ʻO ka wehewehe ʻana i ke ʻano dosis

Nā papa kīwī, 60 mcg: he poepoe, keʻokeʻo, hōʻailona ʻia me kahi hāʻule hoʻokahi ma kekahi ʻaoʻao.

Nā papa kīwī, 120 mcg: poepoe, keʻokeʻo, hōʻailona ʻia me nā hāʻule ʻelua ma kekahi ʻaoʻao.

Nā papa kīwī, 240 mcg: poepoe, keʻokeʻo, hōʻailona ʻia me nā hāʻule ʻekolu ma kekahi ʻaoʻao.

Lapaʻau lāʻau

ʻO ka Desmopressin kahi hōʻailona hoʻohālikelike o ka arginine-vasopressin, ka honu o ka pituitary i ke kanaka. ʻO ka ʻokoʻa ʻē i ka deamination o ka cysteine ​​a me ka weheʻana o L-arginine me D-arginine. Ke alakaʻi nei kēia i kahi hoʻonui nui o ka manawa hana a me ka hala ʻole o nā hopena vasoconstrictor.

Hoʻonui ka Desmopressin i ka kahe o ka epithelium o nā tubule convoluted distal, a hoʻonui i ka reabsorption o ka wai, kahi e hiki ai ke kaohi i ka nui o ka urine i hoʻonui ʻia, he hoʻonui i ka osmolarity o ka urine me ka hoʻohaʻahaʻa iho i ka osmolarity o ka puna koko, a he ʻokoʻa ka nui o ka urination a me kahi hoʻohaʻahaʻa i ka pō).

Lapaʻau lāʻau

ʻO ka bioavailability o desmopressin ma sublingual form ma nā kō o 200, 400 a me 800 μg ka nui o 0.25%.

C_max Loaʻa ka plasma desmopressin i loko o 0.52 mau hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau a hoʻohālikelike ʻia i ka lāʻau i lawe ʻia: ma hope o ka lawe ʻana he 200, 400 a 800 μg C_max helu ia 14, 30 a 65 pg / ml, alana.

ʻAʻole kū ʻo Desmopressin i ka BBB. Hoʻopau ʻia ʻo Desmopressin e nā ʻōpū, T_1/2 2.8 hola

Nā hōʻikeʻike o ka lāʻau Minirin ®

indipidus maʻi maʻi kumu waena,

enuresis nocturnal mau keiki i nā keiki he 6 mau makahiki,

nocturia i loko o nā pākeke e pili ana i ka polyuria nocturnal (hoʻonui i ka urination i nā pākeke, ʻoi aku ka nui o ke koʻi o ka papa ʻula a me ka mea e pono ai ke ala i ka pō ma mua o ka manawa e wehe i ka mea ʻeha) - e like me ka maʻi hōʻailona.

ʻŌpū a me ka lactation

Pau nā ʻike ma ka hoʻohana ʻana o desmopressin i nā wahine hāpai me ka maʻi maʻamau o ka maʻi diabetes (n = 53) e hōʻike ai ʻaʻole hiki i ka desmopressin ke hoʻopilikia i ka hele a me ka olakino o ka wahine hāpai, ka hapai, a i nā keiki hou. ʻAʻole i hōʻike ʻia nā haʻawina holoholona i kahi hopena a i ʻole a hanana ʻole i ka hopena o ka wā e hāpai ai i ka wā hāpai, hoʻoulu a hoʻoulu paha intrauterine, keiki a hānau ʻole a hoʻomehana postpartum.

Pono nā wahine hāpai i nā minirin ® wale nō ma hope o ka loiloi ʻana i nā pōmaikaʻi a me nā pilikia hānai. Ke kau ʻia nei ka lāʻau lapaʻau wale nō ma mua o ka pono o ka makemake i ka makuahine ma mua o ka hopena i ka hopena o ka mea maʻi. Hoʻohana i ka lāʻau lapaʻau i nā wahine hāpai me ka akahele ʻana, e ʻōlelo ʻia e mālama pinepine i ke koko.

ʻO kahi haʻawina o ka waiū umauma o nā wahine i loaʻa desmopressin ma kahi o 300 mcg intranasally i hōʻike ʻia ka nui o ka desmopressin hiki ke komo i ka pūna o ke keiki ka liʻiliʻi a ʻaʻole hiki ke hoʻopilikia i kāna diuresis.

ʻLoe a me ke kākele

Kahiolelo (ma lalo o ka ʻōlelo), no ka resorption. Mai inu i ka papa me ka wai ʻauʻau! Kahi ʻia ka ʻōmaʻomaʻi ʻo Minirin® hoʻokahi.

ʻO nā hoʻohālikelike like ʻole ma waena o nā ʻano waha ʻelua o ka lāʻau lapaʻau penei:

Nā Palaki

Nā Papa Kūʻai Kūʻai 0.1 mg60 mcg 0.2 mg120 mcg 0.4 mg240 mcg

Pono ka lāʻau Minirin ® e lawe i ka manawa ma hope o ka ʻaina, e like hoʻemi ka ingestion i ka hoʻopili ʻana o ka lāʻau lapaʻau a me kona pono.

Diipipidus diabetes. ʻO ka papa ʻōlelo mua o ka Minirin ® ka 60 mcg mau manawa 3 i ka lā. Ma hope iki, ua loli ke ʻano o ka maʻi manu me ka hoʻomaka ʻana o ka hopena therapeutic. ʻO ka paena i ʻōlelo ʻia i kēlā lā i kēia lā aia ma ka pā o 120-77 mcg. ʻO ka lālia mālama maikaʻi loa ʻo 60-120 mcg 3 mau manawa i ka lā sublingually (ma lalo o ka alelo).

Enuresis papa kikoʻī. ʻO ka paipai hoʻomaka ʻia he 120 mcg i ka pō. I ka hala ʻole o ka hopena, hiki ke hoʻonui ʻia i ka nui i 240 mcg. I ka wā mālama, pono ia e kaupalena i ka hoʻoulu wai ʻana i ke ahiahi. ʻO ke aʻo ʻia no ka hoʻomau mau ʻana o 3 mau mahina. Hoʻoholo ʻia ka hoʻoholo e hoʻomau i ka hana lapaʻau ma luna o nā kaila lapaʻau e ʻike ʻia ma hope o ka hoʻokuʻu ʻana o ka lāʻau lapaʻau no 1 pule.

Nocturia. ʻO ka paipai hoʻomaka ʻia he 60 mcg i ka pō sublingually (ma lalo o ka alelo). ʻAʻohe hopena no ka 1 hebedoma, hoʻonui ʻia ka lāʻau i ka 120 μg a ma hope iho i 240 withg me ka piʻi o ka pulu me ka piʻi o ka hapa ʻole o ka ma mua o ka 1 mau manawa i ka pule.

Inā ma hope o 4 wiki o ka mālama ʻana a me ka hoʻoponopono ʻana i ka wai kūpono ʻaʻole i ʻike ʻia kahi hopena lapaʻau kūpono, ʻaʻole ia he kumu e hoʻomau i ka lawe ʻana i ka lāʻau.

Mea hana

Catalent Yu.K. Swindon Zidis Ltd., UK.

ʻO ka mana o ke kānāwai ma kona inoa ka mea i kau inoa ʻia i ke kākau inoa inoa: Ferring AG, Switzerland.

Pono e hoʻouna ʻia nā koi o nā mea kūʻai aku i nā wahi: LLC Ferring Pharmaceuticals. 115054, Moscow, Kosmodamianskaya nab., 52, p. 4.

Kelepona: (495) 287-03-43, fax: (495) 287-03-42.

I ka loaʻa ʻana o ka ʻawaʻawa ma Pharmstandard-UfaVITA OJSC, pono e hoʻouna ʻia nā koi aku o ka mea kūʻai aku i: Pharmstandard-UfaVITA OJSC. 450077, Rusia, Ufa, ul. Khudaiberdina, 28.

Tel./fax: (347) 272-92-85.

ʻAkiʻa, hoʻonohonoho, ʻano

Loaʻa ka lāʻau lapaʻau "Minirin", ke kumukūʻai o ka mea i hōʻike ʻia ma lalo nei, i loaʻa i ʻelua ʻano ʻano like ʻole:

• hoʻolele no ka hoʻohana intranasal,
• keʻokeʻo keʻokeʻo a me ka papa biconvex (no ka hoʻokele waha a me ka hoʻihoʻi ʻana).

ʻO kēlā, a me nā ʻano hana ʻē aʻe e hōʻike ana i kahi antidiuretic, kahi analog o vasopressin. ʻO ka mea ikaika o kēia lāʻau lapaʻau ka desmopressin acetate (desmopressin). Hoʻololi aku nā papa i loko o ka wai i loko o kahi pahu wai a me nā ʻāpana polapona, a me ka ihu o ka ihu - i loko o kahi pahu me kahi dispenser.

Nā kumukūʻai i nā lāʻau lapaʻau ma Moscow

ʻO ka ʻikepili i hāʻawi ʻia ma nā kumukūʻai o nā lāʻau lapaʻau, ʻaʻole ia he makana e kūʻai a kūʻai aku i nā huahana.
Pono ka ʻike i ka ʻike e hoʻohālikelike i nā kumukūʻai ma nā lāʻau lapaʻau kikowaena e hana ana e like me ka Paukū 55 o ke kānāwai Federal "Ma ke Kaʻi o nā lāʻau lapaʻau" i hoʻopaʻa ʻia i ka 12.04.2010 N 61-ФЗ.

Ka hana lāʻau lapaʻau

ʻO ka hana ikaika o ka lāʻau lapaʻau ka hana kikoʻī o ke ʻano like o ka hormone kūlohelohe e like me arginine-vasopressin. Loaʻa ka Desmopressin i ka hoʻololi ʻana i ke ʻano o nā molekene vasopressin a ke hoʻololi nei i ka 8-L-arginine me 8-D-arginine.

Hoʻohālikelike ʻia me vasopressin, ʻo kēia hopena o ka lāʻau (i ka hui pū me ka hiki ke antidiuretic hiki) e alakaʻi i ka hopena i hōʻino ʻia i nā ʻalā o nā huaka o loko a me nā kīʻaha koko. ʻO kēia ke alakaʻi i ka haʻalele o nā hopena maikaʻiʻole makemakeʻole o kahi ʻano spastic.

ʻO ka hopena o ka lāʻau lapaʻau ma muli o kāna kumu. Hiki i ka lāʻau lapaʻau ke hoʻonui i ka maʻi ākea o ka epithelium o ka pālala distalous convoluted no ka wai a hoʻonui i kona reabsorption.

ʻO ka hoʻohanaʻana i ka lāʻau no ka maʻi indipidus e alakaʻi i ka hōʻemi i ka osmolality o ke kaila koko a me ka nui o nā urine i hoʻopuka ʻia, me ke ʻano o ka hoʻonui pinepine ʻana i ka osmolality o ka urine. Kēia hopena pili i ka emi ʻana o ke kahe o ka urination a me ka polyuria nocturnal.

ʻO ka loaʻaʻana o 0.1-0.2 mg o desmopressin hiki iā ia ke hāʻawi i kahi hopena antidiuretic no 9-12 mau hola.

Hōʻikeʻike i nā hōʻike Pharmacokinetic

Hiki iaʻu ke lawe i ka lāʻau "Minirin" me ka meaʻai? Ua ʻōlelo kekahi ʻo nā loea ʻaʻole pono kēia hui. ʻO kēia ma muli o ka loaʻa ʻana o ka meaʻai manawa like nui e hoʻemi nui i ka hoʻokaʻawale ʻana o ka lāʻau mai ka digestive tract (ma kahi o 40%). Loaʻa ka lōʻihi o ka ʻai ʻana i ka lāʻau ma hope o ʻelua mau hola. Ka bioavailability o desmopressin ma waena o 0.08-0.16%. I kēia hihia, ʻaʻole kū ke kumu ikaika i ka BBB.

ʻO ka hoʻoneʻe ʻana o ka lāʻau ke lawe ʻia nei me ka urine (ma hope o nā hola 2-3).

ʻO ka lāʻau lapaʻau "Minirin": kuhikuhi i ka hoʻohana

ʻO ka lāʻau lapaʻau e pono e lawe wale ma hope o ka ʻai ʻana. ʻO kēia ma muli o ka hōʻoia i ka meaʻai hiki ke maʻalahi i ka hoʻopili ʻana i ka huahana a me kona pono.

No laila, pehea ka lawe ʻana i ka lāʻau lapaʻau Minirin? Koho ʻia ka ʻano hana o kēia mea e ke kauka ponoʻī.

I ka hikiʻana o ka insipidus diabetes kikowaena, ʻo ka pona ʻānō i manaʻo ʻia no nā pākeke a me nā keiki he 100 mcg ʻekolu mau manawa i ka lā. I ka wā e hiki mai ana, ua loli ka nui o ka lāʻau lapaʻau ma muli o ka pane a ka mea maʻi i ka mālama ʻana. Ma ke kānāwai, ʻano ka hopena o kēlā me kēia lā ma waena o 0.2-1.2 mg. Eia naʻe, no ka hapanui o nā poʻe, ʻo ka mālama mālama pono ka nui ka 100-200 mcg ʻekolu mau manawa i ka lā.

Pehea e hana ʻia ai ka enuresis? No loko o Minirin me kēia maʻi e kuhikuhi ʻia i ka nui o 200 mcg (lawe ʻia i ka pō). Inā ʻaʻohe hopena kūpono, a laila hiki ke pāpālua ka hopena. I ka mālamaʻana i kēia nahu, pono ka mālama pono ʻana i ka mālama ʻana i ka hoʻopulapula ʻana o ka hoʻokomo wai ʻana i ke ahiahi. ʻO ke ala no ka hoʻomau mau ʻana o 90 lā. ʻO ka hoʻoholo no ka hana ʻoi aku ka lōʻihi o ka hana ʻana e ka kauka ma ka kumu o ka ʻike lapaʻau i ʻike ʻia ma hope o ka hōʻemi ʻana o ka lāʻau i loko o hoʻokahi pule.

Pehea ʻoe e lawe ai i ka lāʻau lapaʻau Minirin i ka pō polyuria? ʻO ka ʻōlelo aʻo no ka hoʻohana ʻana, no ka poʻe pākē me ke ʻano o ke ʻano maʻi, ʻo ka nui i ʻōlelo ʻia ʻo 100 mcg (lawe ʻia i ka pō). Inā hala ka hopena i makemake ʻia no nā lā 7, a laila e pālua ka nui o ka lāʻau lapaʻau, a ma hope aʻe - a quadrupled (me ke ʻano o ka ʻoi aku ma mua o hoʻokahi i hoʻokahi pule). Ke mālama nei i ka maʻi i hōʻike ʻia, pono e hoʻomanaʻo i ka pilikia o ka mālama ʻana o ka wai i loko o ke kino.

Inā ma hope o 4 wiki o ka lapaʻau, e like me ka hoʻoponopono ʻana o ka maʻi, ʻaʻole i ʻike ʻia ka hopena o ke kauka, a laila ʻaʻole hoʻomau ʻia ka lāʻau lapaʻau.

Nā hōʻailona āpau

ʻO ke kau ʻana o ka lāʻau lapaʻau i ka nīnau he alakaʻi i ka hoʻonui o ka lōʻihi o ka hana a ka lāʻau, me ka nui o ka loaʻa ʻana o ka hyponatremia a me ka mālama ʻana o ka wai i loko o ke kino (e komo pū ana ka hoʻomaopopo ʻana, hoʻolilo, a me nā mea ʻē aʻe).

Ke mālama nei i ka hoʻōla no ka hyponatremia, ua pau ka lāʻau lapaʻau, hoʻopau ʻia nā keʻakeʻa ma ka kōkuhi o ka wai, nā infusions o ka hopena hypertonic a isotonic sodium chloride.

Nā hopena hopena

ʻO ka lāʻau "Minirin" no kahi keiki a ʻo ka pākeke e pono ke kuhikuhi wale ʻia ma nā hōʻike ʻana. Ua ʻike ʻia nā hopena ʻokoʻa maʻamau i kēlā mau hanana ke hoʻokō ʻia ka lāʻau lapaʻau me ka ʻole o ka kaupalena ʻana i ke kau ʻana o ka wai, ma muli o ke ʻano ke ʻano o ke kau ʻana, a me ka hyponatremia hoʻi. Kēia mau hana e like me ka asymptomatic a i ʻole e hōʻike ʻia e like me ka ʻeha, ka maʻi, ka puʻupuʻu, nausea, ka luaʻi, ka waha maloʻo, edema peripheral, a me ka loaʻa.

Lactation a me ka wā o ka hāpai ʻana

ʻO nā hopena o ka lawe ʻana i ka lāʻau "Minirin" i nā wahine me ka maʻi maʻi o ka maʻi indipidus e hōʻike ana i ka haʻalele ʻana o nā hopena ʻeha ma ke ʻano o ka hapai ʻana, a me ke kūlana olakino o ka wahine i ka hana ʻana, ka ʻōpū a me ka pēpē.

Pono e hoʻolilo ʻia ka nui o ka desmopressin e komo pū ana i ka pūpū o ka pēpē me ka umauma o ka makuahine i emi iki ma mua o ka mea e hiki ke hoʻopilikia i ka diuresis.

Nā hiʻohiʻona o ka lāʻau

Nui nui nā kikowaena o ka hāmeʻa i nīnau ʻia. Ma ke kānāwai, ʻōlelo ʻia lākou inā ʻaʻole kūpono kēia lāʻau lapaʻau i ka mea maʻi no kekahi kumu a i ʻole. Ma waena o nā lāʻau lapaʻau hopena kūpono loa a me ka hopena, hiki ke hoʻomaopopo ʻia ka mākaukau ma ka lāʻau lapaʻau hou: Adiuretin, Emosynt, Adiuretin SD, Presineks, Apo-Desmopressin, Nativa, Vasomirin, Desmopressin Acetate, Desmopressin.

Hōʻikeʻike i nā kauka a me nā maʻi

ʻO ka mea maʻi e lawe ana a i ʻole he lawe ʻana i ka lāʻau lapaʻau i ka nīnau e waiho i nā loiloi like ʻole e pili ana ia mea. ʻO ka hapa nui o lākou he kūpono. Me ka hoʻokele kūpono, mālama pono ʻia ka lāʻau i haʻi ʻia ma ka nocturnal enuresis i nā kamaliʻi, a me ka polyuria nocturnal i nā pākeke. Eia kekahi, pono ka lāʻau lapaʻau e hakakā i ka diabetes intipidus.

Eia nō naʻe, nui ka poʻe maʻi e ʻōlelo nei i ka lāʻau i haʻi ʻia ma ke ʻano he ʻano kūpono ʻole. I waena o nā mea maʻamau: ka ʻeha, ka dizz, ke kīwaha, ke kuʻi ʻana, ka luaʻi ʻana, ka waha maloʻo, ka edema peripheral, a me ka loaʻa ʻana o ka paona. Ke nānā nei i kēlā mau ʻano, kaukaʻi nā kauka e hoʻōki i ka lāʻau.

Pono e hoʻomaopopo ʻia he helu nui o nā loiloi ʻino e pili ana i ka lāʻau "Minirin" e pili pū ana me kona kumukūʻai. ʻO nā mea maʻi e ʻōlelo ʻoi aku ka nui o ke kumukūʻai o nā papa i 1600-1700 Lūkini Lūkini overpriced. Akā, ʻōlelo nā poʻe loea i hōʻike ʻia ke kumukūʻai i hōʻike ʻia i ka lāʻau lapaʻau. ʻO kēia kahi lāʻau lapaʻau i lawe mai i ka hana.

I ka loaʻa ʻole o nā kālā e kūʻai aku ai, hiki ke loli i ka lāʻau lapaʻau me nā mea kikowaena haʻahaʻa. Eia nō naʻe, ma mua o ka lawe ʻana iā lākou, e pono e kamaʻilio i kāu kauka, no ka mea, heʻokoʻa ʻē aʻe paha nā ʻano hopena, contraindications a me nā ʻano hana.