Amoxiclav - nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, nā loiloi, nā mea hoʻohālike a me nā ʻano dosis (papa 125 mg, 250 mg, 500 mg, 875 mg, 1000 mg, hoʻokuʻu 'ana) o ka lāʻau lapaʻau no ka mālama ʻana i nā maʻi lelo ma ka pākeke, nā keiki a me ka hānau ʻana

I kēiaʻatikala, hiki iā ʻoe ke heluhelu i nā ʻōkuhi no ka hoʻohana ʻana i ka lāʻau lapaʻau Amoxiclav. ^ E Ha yM. Hāʻawi i ka manaʻo o ka poʻe kipa i ka pūnaewele - nā mea kūʻai o kēia lāʻau lapaʻau, a me nā manaʻo o nā loea lapaʻau e pili ana i ka hoʻohana ʻana iā Amoxiclav i kā lākou hana. ʻO kahi noi nui, ʻo ia ke hoʻoikaika ikaika i kāu mau loiloi e pili ana i ka lāʻau lapaʻau: kōkua ka lāʻau lapaʻau a ʻaʻole hoʻi i kōkua i ka hoʻopiʻi ʻana i ka maʻi, nā mea hoʻopiʻi a me nā hopena ʻaoʻao, ua ʻike ʻia, ʻaʻole i hoʻolaha ʻia e ka mea hana ma ka abstract. Nā mea kikoʻī o Amoxiclav i mua o nā mea i loaʻa i nā analogue hoʻokolohua. Hoʻohana no ka mālama ʻana i nā ʻano maʻi like ʻole i nā pākeke, nā keiki, me ka wā hāpai a me ka lactation. Lilo ka ʻawaʻawa a me nā hopena hiki aʻe ma hope o ka lawe ʻana iā Amoxiclav.

Amoxiclav - ka hui pū ʻana o ka amoxicillin - penicillin semisynthetic me ka laulā ākea o ka hana antibacterial a me ka acid clavulanic - kahi hoʻohui beta-lactamase paʻa ʻole. Hoʻokomo ʻia ka hoʻohuihui Clavulanic i kahi kaila paʻa ʻole me kēia mau kaomi a hōʻoia i ka kūʻē o ka amoxicillin i nā hopena o nā beta-lactamases i hoʻoili ʻia e microorganisms.

ʻO ka mole Clavulanic, like me ka hana i ka antibiotics beta-lactam, he hana intrinsic antibacterial nāwaliwali.

Loaʻa i ka Amoxiclav kahi ākea ākea o ka hana antibacterial.

ʻO ia ke kūleʻa e kū'ē i nā pilikia o ke kaʻaxicillin, e komo pū ai i nā seleni e hana ana i ka beta-lactamases, incl aerobic gram-positive bacteria, aerobic gram-negative bacteria, anaerobic gram-positive bacteria, gram-negatif anaerobes.

Lapaʻau lāʻau

ʻO nā hiʻohiʻona nui o ka pharmacokinetic o ka amoxicillin a me ka acid clavulanic i like. ʻEleʻa maikaʻi nā māhele ʻelua ma hope o ka lawe ʻana i ka lāʻau lapaʻau i loko, ʻaʻole e hoʻopilikia i ka pae o ke kao ʻana. Hōʻike ʻia nā ʻaoʻao ʻelua i ka nui o ka hoʻoili ʻana i nā ʻōmole o nā kino a me nā ʻōpio (pūpū, ke pepeiao waena, nā pleural a me nā peritoneal wai, ka ʻōpū, ka ovaries, a me nā mea hou aku). Hoʻopaka hoʻi ʻo Amoxicillin i ka wai synovial, ate, prostate gland, palatine tonsils, kiko o ka ʻōpū, ka puʻuwai ʻana, nā mea huna o nā sinuses, ka lawaiʻa, nā mea huna huna bronchial. ʻO Amoxicillin a me clavulanic acid ʻaʻole i komo i ka BBB me ka meninges uninflamed. ʻO Amoxicillin a me clavulanic acid e hoʻowalewale i ka pale o ka placental a ma o ka nui o nā wahi i hoʻopili ʻia i loko o ka waiū umauma. Hōʻikeʻo Amoxicillin a me clavulanic acid i ka hoʻohaʻahaʻa haʻahaʻa i nā protein plasma. Amoxicillin i hoʻoneʻe ʻia i ka ʻaoʻao, clavulanic acid ua hoʻopiʻi ʻia i ka metabolism ikaika. Hoʻopili ʻia ʻo Amoxicillin e nā keiki i aneane e loli a ka huna ʻia o ka tubular a me ka filtration glomerular. Hoʻokumu ʻia ka hoʻohuihui Clavulanic e ka filtration glomerular, ma kahi ʻāpana i nā metabolites.

Nā Hōʻike

Nā maʻi ʻeha e hōʻake ʻia e nā ʻōpala hikiʻole i nā microorganisms:

nā hopena o ka ʻōpū hanu o luna a me nā mea komo ENT (e pili ana i ka sinusitis a me ke keaka sinusitis, nā pāpā a me ka ukiuki otitis, pharyngeal abscess, tonsillitis, pharyngitis),
nā maʻi o ka ʻōpū hanu haʻahaʻa loa (me ka hoʻohui ʻia o ka bronchitis nui me ka superinfection bakalula, bronchitis maʻi, pneumonia),
maʻi maʻi maʻi urinary
maʻi maʻi gynecological
ka hopena o ka ʻili a me nā kiko palupalu, e komo pū me nā holoholona a me ke kanaka.
nā iwi a me nā hui pili kino,
biliary tract infection (cholecystitis, cholangitis),
maʻi maʻi odontogenic.

E hoʻokuʻu i nā palapala

ʻO ka pauka no ka hoʻomākaukau ʻana i ka injection no ka hoʻokō intravenous (4) 500 mg, 1000 mg.

ʻO ka pauka no ka hoʻomākaukau ʻana no ke kaʻina o ka hoʻopale waha ma 125 mg, 250 mg, 400 mg (kahi ʻano kūpono no nā keiki).

ʻO nā papa kiʻi ʻoniʻoni 250 mg, 500 mg, 875 mg.

Nā ʻōkuhi no ka hoʻohana a me ka helu ʻana

ʻO nā pākeke a me nā keiki ma mua o 12 mau makahiki (a ʻoi aku paha ma mua o 40 kg o ke kaumaha o ke kino): ʻo ka lāʻau maʻamau no ka maʻi maʻamau a hōʻemi i nā maʻi he 1 papa 250 + 125 mg kēlā me 8 mau hola a i ʻole 1 papa 500 + 125 mg i kēlā me kēia mau hola 12, ma kahi o ka maʻi koʻikoʻi. a me nā maʻi ʻeha hanu - 1 papa 500 + 125 mg i kēlā me 8 mau hola a i ʻole 1 papa. 875 + 125 mg i kēlā me kēia mau hola 12. ʻAʻole i kuhikuhi ʻia nā papa no nā keiki ma lalo o 12 makahiki (emi iho ma lalo o 40 kg o ke kaumaha o ke kino).

ʻO ka nui loa o ka lā no clavulanic acid (ma ke ʻano o ka paʻakai pākela) he 600 mg no nā pākeke a me 10 mg / kg o ke kaumaha o ke kino no nā keiki. ʻO ka nui loa o ka lā ma amoxicillin o 6 g no nā pākeke a he 45 mg / kg o ke kaumaha o ke kino no nā keiki.

ʻO ke ala e mālama ai i nā lā 5-14. Hoʻoholo ʻia ka lōʻihi o ke ʻano o ka mālama ʻana e ke kauka hele mai. ʻAʻole pono e hānai ʻia ʻoi aku ma mua o 14 mau lā inā ʻaʻole e hoʻopaʻa loiloi i ka lua.

Nā kūmole no nā maʻi odontogenic: 1 kāpī. 250 +125 mg i kēlā me kēia 8 mau hola a i ʻole 1 papa ʻalani 500 + 125 mg i kēlā me kēia mau hola 12 no 5 mau lā.

ʻO nā haʻahaʻa no ka hikiʻole o ka renal: no nā mea maʻi me ka hikiʻole i ke aʻalolo pale (Cl creatinine - 10-30 ml / min), ʻo ka papaʻaina he 1 papa. 500 + 125 mg i kēlā me kēia mau hola 12, no nā mea maʻi me ka maikaʻi ʻole o ka renal (ʻoi aku ʻo Clin ma mua o 10 ml / min), ka papaʻaina he 1 papa. 500 + 125 mg i kēlā me kēia 24 hola

Loaʻa ka hopena

ʻO nā hopena ʻaoʻao ma ka hapanui he mau māmā a transient.

lilo ka momona
paila, mamaila,
nā ninia
ʻeha ka ʻōpū
pruritus, urticaria, erythematous rash,
angioedema,
anaphylactic haʻalulu,
kūloko
papula derfitis,
Hōʻike ʻia ʻo Stevens-Johnson
leukopenia hoʻolilo (me ka neutropenia),
thrombocytopenia
hememia anemia,
eosinophilia
ʻeha, poʻomana,
mau mea hoʻokūkū (hiki i nā mea maʻi me ka hana ʻole o ka hakahaka i ka wā i lawe ai i ka lāʻau i nā kaila kiʻekiʻe).
hopohopo o ke kaumaha
ʻōpala
nephritis interstitial,
crystalluria
ka hoʻomohala ʻana o ka superinfection (me ka candidiasis).

Nā Hoʻohui

hypersensitivity o kekahi o nā lāʻau o ka lāʻau,
hypersensitivity i ka mōʻaukala i penicillins, cephalosporins a me nā antibiotika lika-lactam,
ka mōʻaukala o nā hōʻike no ka jaundice cholestatic a me / a i ʻole nā hana ʻē aʻe i hoʻopilikia ʻia i kumu no ka lawe ʻana i ka acid amoxicillin / clavulanic,
maʻi mononucleosis hopohopo a me ka maʻi lymphocytic.

ʻŌpū a me ka lactation

Hiki ke kuhikuhi ʻia ʻo Amoxiclav i ke wā hāpai 'ana inā he mālamalama mau.

ʻO Amoxicillin a me clavulanic acid i kahi liʻiliʻi liʻiliʻi e hoʻopili ʻia i loko o ka waiū umauma.

Nā ʻōlelo kikoʻī

Me kahi papa o ka mālama ʻana, e nānā pono ʻia nā hana o ke koko, ka ate a me nā ʻōpū.

I nā mea maʻi me ka hana renal impaired koʻikoʻi, kahi hoʻoponopono kūpono o ka dimen regimen a i ʻole he piʻi ʻana ma waena o ke dosing pono.

I mea e hōʻemi ai i ka hoʻopau ʻia o nā hopena ʻino mai ka gastrointestinal tract, pono ke lawe ʻia ka lāʻau lapaʻau me ka ʻai.

Hana i nā hoʻokolohua Laboratory: hāʻawi ʻoi i ka nui o ka hakuxicillin i ka hopena maikaʻi ʻole i ka glucose i ka wai i ka wā e hoʻohana ai i ka hopena o Benedict a i ʻole ka hopena a Felling. Hoʻomaopopo ʻia nā ʻano hopena Enzymatic me ka glucosidase.

Hoʻohana ʻia ka hoʻohana ʻana o Amoxiclav me ka hoʻohana like ʻana i ka waiʻona i nā ʻano ʻē aʻe, no ka mea, ua hoʻomāhuahua loa ka pilikia o nā maʻi o ka ate ma ka wā e lawe ana iā lākou i ka manawa like.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a kāohi i nā mīkini

ʻAʻohe ʻikepili e pili ana i ka hopena maikaʻi loa o Amoxiclav i nā makemake i ʻōlelo ʻia i ka hiki ke lawe i kahi kaʻa a hana paha me nā mīkini.

Hoʻohui nūhou

Me ka hoʻohana pū ʻana o ka maʻi Amoxiclav me nā antacids, glucosamine, laxatives, aminoglycosides, hoʻopihapiha ʻia nā kīmole me ka acid ascorbic - hoʻonui.

Diuretics, allopurinol, phenylbutazone, NSAIDs a me nā lāʻau lapaʻau ʻē aʻe e poloka ana i ka ʻōlelo huna tubular e hoʻonui i ka pehu o ka amoxicillin (clavulanic acid e hoʻōla nui ʻia e ka glomerular filtration).

Me ka hoʻohana pinepine ʻana o Amoxiclav e hoʻonui i ka nāo o ka methotrexate.

Me ka hoʻohana like ʻana o Amoxiclav me allopurinol, ke hoʻonui nui nei ka ulu o ka exanthema.

ʻO ka hui lawelawe me ka disulfiram e hōʻalo.

Ma kekahi mau mea, ʻo ka lawe ʻana i ka lāʻau e hiki ke hoʻonui i ka manawa prothrombin, i kēia mea, pono e hoʻomaʻamaʻa ʻia i ka wā e kuhikuhi ana i ka anticoagulants a me ka lāʻau lapaʻau Amoxiclav.

ʻO ka hui pū ʻana o ka amoxicillin me rifampicin he antagonistic (aia kekahi mauwaliwali ʻana o ka hopena antibacterial).

ʻAʻole pono e hoʻohana ʻo Amoxiclav i ka manawa like me ka antibiotics bacteriostatic (macrolides, tetracyclines), sulfonamides ma kahi o kahi hiki ke emi i ka hopena o Amoxiclav.

Hoʻopala ka Probenecid i ka hoʻonuiʻana i ka amoxicillin, e hoʻonui ana i kona koʻikoʻi serum.

Hoʻemi ka poʻe antibiotics i ka hopena o nā mea hoʻohālikelike waha.

Nā hōʻike o ka antibiotika Amoxiclav

Hoʻololi nā kumu hoʻohālike o ka waiwai ikaika: