Nā papa kekona Amoxiclav

ʻO ka hui papa 250 mg / 125 mg ua hoʻokomo ʻia nā mea ikaika pauxicillin (puka o trihydrate) a kāmele clavulanic (ka puka paʻakai). Aia pū kekahi papa i nā mea kōkua: MCC sodium croscarmellose.

Nā papa kekona Amoxiclav ʻO 2X 625 mg a me 1000 mg ka mea e hoʻohana ai i nā ʻākana hana amoxicillin a me ka waila clavulanic, a me nā mea hou aʻe: anhydrous colloidal silicon dioxide, ʻono, lau'āpana, ka mea i hao ʻia i ka hao keleawe, talc, ke kālai ʻoki ʻana me ka ʻĀina MCC.

ʻO ka helu ʻia ʻana o papa Amoxiclav Quicktab 500 mg a me 875 mg piha nā mea amoxicillin a me ka hoʻohuihui clavulanic, a me nā mea hou aku: ka aniodrous colloidal silicon dioxide, nā poni, kuhi, aspartame, ka oxide iron iron, talc, ka hydrogenated castor oil, MCC silicate.

ʻO ka helu ʻia ʻana o ka pauku i hoʻomākaukau ʻia ai ke kāpae ʻia ʻo Amoxiclavka mea nō hoʻi i ka amoxicillin a me ka clavulanic acid, a pēlā pū me nā mea hana ʻole i ka sodium citrate, MCC, sodium benzoate, mannitol, sodium saccharin.

ʻO ka helu ʻia ʻana o pauku no ka hoʻomākaukau ʻana o ka infusion Amoxiclav iv piha ka amoxicillin a me ka clavulanic acid.

E hoʻokuʻu i ke ʻano

ʻO ka lāʻau lapaʻau ma ke ʻano o nā papa. Amoxiclav 250 mg / 125 mg - nā papa i uhi ʻia, ʻo ka pākī he 15 pcs.

Amoxiclav 2X (500 mg / 125 mg, 875 mg / 125 mg) - nā papa, kahi i ulana ʻia, aia paha he 10 a 14 mau pcs.

Amoxiclav (500 mg / 125 mg, 875 mg / 125 mg) i loaʻa ma ke ʻano o nā papa i hoʻowalewale ʻia, i loko o kahi pānaʻi - 10 mau papa papaʻu.

Eia nō hoʻi, hana ʻia ka huahana i loko o kahi ʻano o kahi paura i hana ʻia ai ke kaʻaʻa ʻana, ka ʻona i piha ka pauka no ka hoʻomākaukau ʻana o 100 ml o ka huahana.

Hoʻokumu ʻia ka huaʻai, kahi mai ka hoʻāla ʻia, e mālama ʻia ma ka naʻau. ʻO ka hue he 600 mg o ka lāʻau (amoxicillin 500 mg, clavulanic acid 100 mg), 1,3 g nā kīʻaha i loaʻa mai kahi (amoxicillin 1000 mg, clavulanic acid 200 mg), 5 fl.

Ka hana lāʻau lapaʻau

Hāʻawi i ka Annotation ka ʻike nā maʻi maʻi ʻO Amoxiclav (INN Amoksiklav) he māka ākea ākea ākea. Nā hui Antibiotic: nā penicillins ākea ākea. ʻO ka hoʻonohonoho o ka lāʻau lapaʻau ka amoxicillin (penicillin semi-synthetic) a me clavulanic acid (β-lactamase inhibitor). ʻO ka heleʻana o ka acid clavulanic i ka mākaukau e hōʻoia i ka pale ʻana o ka amoxicillin i ka hana o ka β-lactamases, kahi i hoʻoili ʻia e nā microorganisms.

Hoʻohālike ke ʻano o ka waikawa clavulanic i ka antibiotika beta-lactam, ua loaʻa hoʻi i kēia ʻano nā hopena antibakterial. Hoʻohana ʻo Amoxiclav i nā kūwaho e hōʻike ana i ka naʻau i ka amoxicillin. ʻO kēia ka lālani nā huakini maikaʻi-gram, aerobic gram-negative bacteria, anaerobes gram-maikaʻi a me ka gram-né maikaʻi.

Pharmacokinetics a me ka lāʻau lapaʻau

Wahi a ke alakaʻi hoʻomohala Vidal, ma hope o ka hoʻomoʻa waha, ua paʻa nā mea ʻelua mai ke ahe ʻana o ke aʻai, ʻaʻole pili ʻia ka hoʻoulu ʻia ʻana o nā māhele i ka ʻai ʻana, no laila ʻaʻole i hopohopo pehea e lawe ma mua a i ʻole hoʻi i ka pāʻina. Mahele kiʻekiʻe ma koko nānā ʻia hoʻokahi hola ma hope o ka lawe ʻana i ka lāʻau. ʻO nā hua ʻelua o ka lāʻau lapaʻau ka mea e māhele ʻia i nā likika a me nā kiko. Komo pū ʻia ʻo Amoxicillin i loko o ke ake, synovial fluid, prostate, tonsils, gall bladder, muscle muscle, saliva, bronchial secretion.

Inā ʻaʻole i palau ʻole nā ​​membrane o ka lolo, ʻelua mau mea ikaika i ka komo ʻana ma o BBB. I ka manawa like, neʻe nā mea ikaika i ka pale o ka placental, ua hoʻoholo ʻia ko lākou hāpana ma ka waiū umauma. Hoʻopili lākou i nā protein koko i kahi liʻiliʻi loa.

I loko o ke kino, ka hoʻomalu ʻana ʻo amoxicillin i ka ʻāpana hoʻokūkū, hamili nā clavulanic acid i kahi ulu ikaika. Hoʻokuʻu ʻia ia mai ke kino ma o ka peʻa, nā mea waiwai ʻole o nā mea ikaika e hoʻopili ʻia e nā ʻāpana a me nā ʻōpū. ʻO ka hapalua o ka ola ʻo ka amoxicillin a me ka waikawa clavulanic ma kahi o 1-1,5 hola.

Nā manaʻo no ka hoʻohana ʻana iā Amoxiclav

Ua hoʻohālikelike ʻia ʻo Amoxiclav no nā maʻi maʻi pāpaʻi a me nā maʻi e ulu ana ma muli o ka hopena o nā microorganisms kūpono i kēia lāʻau lapaʻau. Ua hoʻoholo ʻia nā hōʻike ʻana no ka hoʻohana ʻana i kēia lāʻau lapaʻau.

• nā maʻi āpau o ke kino ENT, a me nā maʻi pūpaʻa o ka ʻōpū o ka ʻōpū ʻana hope (otitis mediahopohopo lealea, sinusitis, pharyngitisPaola)
• nā maʻi maʻi urinary (me pūnana cystitisma prostate etc.)
• mai nā maʻi o ka ʻōpū o ka ʻōpū hanu haʻahaʻa (pneumonia, ʻOluominike kūlia a me ke ʻano)
• nā maʻi gynecological o kahi ʻano maʻi,
• nāʻiʻi o ka pilina a me nā iwi,
• mai nā maʻi ʻeha o nā palupalu palupalu, ka ʻili (a me nā hopena o nā kakaka).
• pāʻālua biliary tract (cholangitis, cholecystitis),
• maʻi maʻi odontogenic.

ʻO nā mea ʻē aʻe e kōkua ai iā Amoxiclav, pono ʻoe e nīnau i kahi loea no ka kūkākūkā pilikino.

Nā Hoʻohui

Ke hoʻoholo nei i ke kumu o nā lāʻau lapaʻau a me nā ʻano like ʻole o ke kōkua o ka lāʻau lapaʻau, pono kekahi e noʻonoʻo i ka contraindications i loaʻa.

• maʻi mononukini infectious,
• ka maʻi ʻawaʻawa o mua a i ʻole jaundice cholestatic inā lawe ʻia i ka acid clavulanic a i ʻolexicillin,
• leukemia lymphocytic,
• ka hopena kiʻekiʻe i nā lāʻau lapaʻau lāʻau mai ka hui o cephalosporins, penicillins, a me nā mea hou e pili ana i ka beta-lactam,
• ʻike kiʻekiʻe i nā mea ikaika o ka lāʻau lapaʻau.

Ua hoʻomaopopo maikaʻi ʻia i nā poʻe e hōʻeha nei i ka palaka pale, nā poʻe me nā maʻi ʻeha koʻikoʻi.

Nā hopena hopena

Ke lawe nei i kēia ʻano antibiotik, hiki i nā hopena kino ke ʻano i ka mea maʻi.

• ʻŌnaehana nenoaiu: kahiʻino mea momonahāmeʻa nausea nā ninia, ma nā hihia līpoki, hōʻike ʻana i ka ʻeha o ka ʻōpū, hiki i ka ʻili o ke akeʻa, hoʻokahi mau hōʻike hepatitis, jaundice, pseudomembranous colitis.
• ʻŌnaehana Hematopoietic: i nā hanana līpoki, hiki i ka leukopenia hiki hou, thrombocytopenia, i nā hihia loaʻa pinepine loa - eosinophilia, pancytopenia.
• Hōʻikeʻike Allergic: huuEʻokiʻoki iā erythematous urticaria, i nā hanana ʻehā - anaphylactic pīhoihoierythema exudative, ka māla ʻana, vasculitis allergic, hōʻike hōʻike hoʻokahi - Stevens-Johnson syndrome, pustulosis, exfoliative dermatitis.
• Pūnaehana ʻōnaehana lawelawe: āhāhuʻe, lie kanikela, i nā hanana līpoki - nā hoʻopaʻapaʻa, he manaʻo i ke kaumaha, hyperactivity, ʻōpala.
• ʻŌnaehana papa maʻi: crystalluria, nephritis interstitial.
• I nā hanana pinepine, hiki i ka superinfection.

Ua hoʻomaopopo ʻia, ʻo ia ka mālama ʻana, ma ke ʻano he kānāwai, ʻaʻole ia e hoʻonāukiuki i nā hopena ʻaoʻao.

Nā kauoha no ka hoʻohana ʻana iā Amoxiclav (Ke ʻano a me ka helu ʻana o ka ʻAmoxiclav no nā pākeke)

ʻAʻole kuhikuhi ʻia ka lāʻau lapaʻau i nā papa no nā keiki ma lalo o 12 makahiki. Ke koho ʻana i ka lāʻau lapaʻau, pono e noʻonoʻo i ka ʻoni ʻia i kēlā me kēia lā ʻo ka clavulanic acid he 600 mg (no nā pākeke) a me 10 mg no 1 kg o ke kaumaha (no kahi keiki). ʻO ka ʻawaʻawa i kēlā me kēia lā ʻo ka ʻAyxicillin e 6 g no kahi pākeke a me 45 mg no ka 1 kg o ke kaumaha no kahi keiki.

Hoʻomau ʻia ka hoʻomākaukau ʻana no ka makua makua i ka hoʻohemo ʻana i nā ʻike o ka pākahi i ka wai no ka maʻi injection. E hoʻohemo i ka 600 mg o ka lāʻau, pono ʻoe i 10 mau molika o ka wai, e hoʻoheheʻe i 1,2 g o ka lāʻau - 20 ml o ka wai. Pono e hoʻolōʻihi ʻia ka mea hoʻonā no ka mau minuke 3-4. Hoʻomau hou ka infusion intravenous no 30-40 mau minuke. Mai hoʻokuʻu i ka hoʻonā.

Ma mua o ka wai maʻi no ka pale ʻana i nā hoʻopiʻi purulent, pono ʻoe e komo i ka intravenously 1.2 g o nā lāʻau lapaʻau. Inā aia ka hopena o nā hoʻopiʻi ʻana, hoʻomālamalama ʻia ka lāʻau lapaʻau ma ka hana ʻana a lawelawe maoli paha i ka manawa ma hope o ka hana. Hoʻoholo ʻia ka lōʻihi o ke kau ʻana ma ke kauka.

Nā papa kekona Amoxiclav, nā ʻōlelo e hoʻohana ai no ka hoʻohana

Ma ke ʻano he kānāwai, e loaʻa ana i nā pākeke a me nā keiki (ʻoi aku ka paona ma mua o 40 kg) ka papa ʻaina 1 i kēlā me kēia hola. (375 mg), hoʻolako ʻia he maʻalahi a maʻalahi paha ka maʻi. ʻO kahi mea hoʻoponopono ʻē aʻe kūpono ʻia i kēia hihia he 1 papa i kēlā me kēia 12 mau hola. (500 mg + 125 mg). No nā maʻi maʻi pāpaʻi loa, ʻo ia hoʻi no nā maʻi maʻi pāpaʻi o ka ʻōpū ʻana o ka ʻōpū, hōʻike ʻia ka papaʻa ʻia i kēlā me kēia hola ʻewalu. (500 mg + 125 mg) a i ʻole e hoʻokomo i kēlā me kēia hola 12 i ka papaʻaina. (875 mg + 125 mg). Wahi a ka maʻi, pono ʻoe e lawe i ka lāʻauʻōmaʻomaʻi no ka ʻelima a ʻumikumamāhā mau lā, akā pono e kaukaʻi ʻo kaukaʻi i kahi regimen lapaʻau.

No nā mea maʻi me nā maʻi odontogen, e hōʻike i ka lāʻau lapaʻau i kēlā me kēia 8 mau hola, 1 papa. (250 mg + 125 mg) a i ʻole 12 mau manawa, 1 papa i kēlā (500 mg + 125 mg) noʻelima mau lā.

ʻO nā poʻe me ka palaha haʻahaʻa nā mālamalama maikaʻi ʻoleHōʻike ʻia ka hoʻokipa ʻana o ka papaʻaina 1 papa. (500 mg + 125 mg) kēlā me kēia mau hola he ʻumikumamālua. ʻO ka pilikia o ka renal ʻo ke kumu no ka hoʻonui ʻana o ka waena ma waena o nā aniani a hiki i ka 24 hola.

Hoʻopau iā Amoxiclav, nā ʻōlelo e hoʻohana ai

Hoʻohana nā keiki o ka mea maʻi no ka helu helu ʻana ma ke ʻano o ka kaumaha o ke keiki. Ma mua o ka hoʻomākaukau ʻana i ka palaila, pono ʻoe e lūlū maikaʻi i ka waʻa. I ʻelua mau kala, hoʻohui ʻia ʻo 86 ml wai i ka pahu, i kēlā me kēia manawa ke pono e lūlū maikaʻi ʻia kona mau mea. Pono e nānā ʻia ma kahi huina helu he 5 ml o ka huahana. Hāʻawi i kahi hāmeʻa hilinaʻi ma muli o ka makahiki a me ke kaumaha o ke keiki.

Nā ʻōkuhi no ka hoʻohana ʻana iā Amoxiclav no nā keiki

Mai ka hānau ʻana a ʻekolu mahina, e kau ʻia nā keiki i ka lāʻau ma ka awelika o 30 mg no 1 kg o ka paona (pākahi i kēlā me kēia lā), pono e hoʻokaʻawale ʻia kēia ʻano ma ka wā o ka manawa maʻamau. Mai nā makahiki he ʻekolu mau mahina, ua ʻōmike ʻia ʻo Amoxiclav ma kahi o ka 25 mg no ka 1 kg o ka paona, he like like ʻole ia me nā huina. I ka hihia o nā maʻi hopohopo o ke kaumaha hōʻeha, ua kuhikuhi ʻia ka nui ma ka nui o 20 mg no 1 kg o ka paona, ua mahele ʻia i ʻekolu mau hoʻokō. I nā maʻi hopohopo koʻikoʻi, ua kau ʻia ka nui ma ka nui o 45 mg no 1 kg o ke kaumaha, hoʻokaʻawale iā ia i ʻelua inikua i ka lā.

Nā ʻōkuhi no ka hoʻohana ʻana iā Amoxiclav Quicktab

Ma mua o ka lawe ʻana, pono e hoʻokaʻawale ka papa papa ma 100 ml wai (ʻoi aku ka nui o ka wai). E hoʻomoʻi maikaʻi i nā ʻike i mua o ka hoʻohana ʻia. Hiki iāʻoe ke hoʻomaʻemaʻe i ka papa, ʻoi aku ka maikaʻi e hoʻohana i ka lāʻau lapaʻau ma mua o ka ʻai ʻana. ʻO nā pākeke a me nā keiki ma hope o ka hiki ʻana o nā makahiki he 12 e lawe i 1 papa i ka lā. 625 mg 2-3 mau lā i ka lā. I nā maʻi hōʻeha kino, kuhikuhi ʻia ka papa ʻaina 1. 1000 mg 2 mau lā i ka lā. ʻAʻole pono e hānai ʻia ʻoi aku ma mua o 2 mau pule.

ʻO kekahi manawa ke kauka nei ke kauka i nā mea hoʻohālike o ka lāʻau lapaʻau, no ka laʻana, Flemoklav Solutab a me nā mea ʻē aʻe.

Amoxiclav me ka angina

ʻO ka lāʻau Amoxiclav ʻeha ka ʻeha kauoha ʻia kahi pākahi 1 papa papaʻa. 325 mg ka manawa hoʻokahi 8 mau hola. ʻO kekahi hanana hoʻoponopono hou e pili ana i ka lawe ʻana i ka papa papa papa 1 i kēlā me kēia 12 mau hola. Hiki ke kauka i ke kauka i kahi kiʻekiʻe o ka antibiotic inā he maʻi nui ka maʻi ma ka pākeke. ʻO ka mālama ʻana i ka angina i nā keiki e pili ana i ka hana o kahi paʻa. E like me ke kulekele, ua kuhi ʻia ʻo 1 mau kāula (ʻo ke kue iau ʻia he 5 ml). Hoʻoholo ʻia ke kaila o ke komo ʻana e ke kauka, nā ʻōlelo aʻo e pili ana i nā mea nui e hahai. Pehea e lawe ai iā Amoxiclav i nā keiki me ka angina e hilinaʻi nei i ka nui o ka maʻi.

Nā kaha amoxiclav no ka sinusitis

Ua kōkua anei ʻo Amoxiclav sinusitis, ke kumu ia i nā kumu a me nā ʻano o ka hele o ka maʻi. Hoʻoholo ʻia ka dosage e ka otolaryngologist. Hoʻomaopopo ʻia e lawe ʻoe i kahi papa 500 mg ʻekolu ʻekolu i ka lā. Ehia lā e lawe ai i ka lāʻau lapaʻau ma muli o ka nui o ka maʻi. Akā ma hope o ka hala ʻana o nā hōʻailona, ​​pono e lawe i ka lāʻau lapaʻau no ʻelua lā ʻelua.

Ke keu

I mea e pale aku ai i ka overdose, e pono e mālama pono ʻia ka kaona i ʻōlelo ʻia no nā keiki a me ka hewa o Amoxiclav no nā pākeke. A ʻoiai, e hoʻomaʻamaʻa pono ʻoe i nā ʻōkuhi a nānā paha i kahi wikiō e pehea e hoʻoheheʻe ai i ke kaʻaʻa.

Ua hōʻike aku ka Wikipedia me kahi overdose o ka lāʻau lapaʻau, hiki i kekahi mau mauʻano leʻaleʻa i hiki mai, akā ʻaʻohe data i nā kūlana e hoʻoweliweli ʻana i ke ola no ka mea maʻi. Hele a overdose. ʻeha ka ʻōpū, utuka, nā niniahoihoi. I nā hihia koʻikoʻi, hiki i ka hoʻopaʻi.

Inā lawe ʻia ka lāʻau lapaʻau i kēia manawa, hōʻike ʻia ka gastric lavage, hōʻike ʻia carbon hoʻoneʻe. ^ E Ha yM. ʻO ka mea maʻi e nānā pono ʻia e ke kauka. E ola pono i kēlā hihia hemodialysis.

Hoʻohui

ʻOiai ke lawe ʻana i ka lāʻau lapaʻau me kekahi mau lāʻau lapaʻau, hiki mai nā hanana kūpono ʻole, ʻo ia ke kumu e pono ai e hoʻohana ʻia nā papa, me ke kō a me ka hoʻokele ʻana o ka lāʻau lapaʻau e like me ka nui o nā lāʻau lapaʻau.

Lilo ka hoʻohana ʻana i nā lāʻau me Hoʻolauleʻa, antacids, aminoglycosides, laxative drug ke iho nei i ka hoʻohemo ʻana o Amoxiclav, i ka manawa i lawe pū ʻia me ʻO ka acidorborbic - Hoʻohālikelike ʻia ke komo ʻana.

Me ka hoʻāʻo ʻana me ka phenylbutazone, diuretics, NSAIDs, Allopurinol a me nā lāʻau ʻē aʻe e hoʻopaʻa ana i ka ʻoni ʻana o ka tubular, ka ulu ʻana o ke kahe o ka amoxicillin e tupu.

Inā mālama ʻia ka hoʻokō pinepine ʻana o nā anticoagulants a me Amoxiclav, hoʻonui ka manawa prothrombin. No laila, pono e kuhikuhi i nā kālā i loko o kēlā hui me ka mālama pono.

Hoʻonui ka Amoxiclav i ka nāʻu Methotrexate oiai e lawe ana.

Ke lawe ʻana iā Amoxiclav a Allopurinol hoʻonui ka loli o ka exanthema.

ʻAʻole pono e lawe ʻia i ka manawa like Disulfirama me ʻAmociclav.

ʻO nā antagonist e hoʻokō i luna ʻo ia ʻo amoxicillin a Rifampicin. ^ E Ha yM. Hoʻolaumaha nā lāʻau lapaʻau i ka hopena antibacterial.

ʻAʻole pono e lawaiʻa ʻia ʻo Amoxiclav a me nā bacteriostatic antibiotics (tetracyclines, macrolides), a me ka sulfanilamides i ka manawa like, no ka mea hiki i kēia mau lāʻau ke hōʻemi i ka hopena o Amoxiclav.

Probenecid hoʻonui i ke kūoʻi o ka amoxicillin a hoʻoheheʻe i kāna excretion.

Ke hoʻohana nei iā Amoxiclav, hiki ke emi i ka hopena o nā hopena o nā kūlohelohe waha.

Nā ʻōlelo kikoʻī

Mai ka hapa nui o ka poʻe me ka lepaemia lymphocytic me ka mononucleosis hopohopo a i loaʻa Ampicillin, ma hope aʻe i ʻike ʻia i ka hōʻike ʻana o ka erythematous rash, ʻaʻole i ʻōlelo ʻia kēlā mau kānaka e lawe i ka antibiotics o ka hui ampicillin.

Hāʻawi ʻia i ka poʻe me kahi penchant no nā pepeke.

Inā hoʻoholo ʻia kahi papa o ka lāʻau me ka lāʻau lapaʻau no nā pākeke a i ʻole nā ​​keiki, he mea nui ia e nānā i nā kauā, a me ka moʻi, a me ke kahe koko.

ʻO ka poʻe i hana i ka hana renal pono e hoʻoponopono i kahi hoʻoponopono a i ʻole ka nui o ka manawa ma waena o nā lāʻau lapaʻau.

He mea kūpono loa e lawe i ka lāʻau lapaʻau i ka wā o ka pāʻina e hōʻemi i ka hopena o ka hopena o ka hopena mai ka hoʻopili ʻana.

I ka poʻe maʻi e hoʻomaʻamaʻa ana me Amoxiclav, hiki ke nānā ʻia ka hopena kūmole i ke kaʻina hana e pili ana i ka ʻike o ka glucose i loko o ka urine i ka wā e hoʻohana ai i ka hopena o Felling a i ka hoʻoulu hou ʻana o Benedict.

ʻAʻohe ʻikepili e pili ana i ka hopena maikaʻi loa o Amoxiclav i ka hiki ke hoʻokae i nā kaʻa a hana me nā mīkini kūpono.

ʻO nā mea maʻi e makemake ana iā Amoxiclav he mea ʻoniʻoni a i ʻole, pono e hoʻomau ʻia ma ka manaʻo o ka lālau huʻawaʻi he lāʻau ia e kūloi pū kekahi.

Hoʻomaopopo ʻia e hoʻopau i ka nui o ka wai a me nā waiila ʻē aʻe i ka wā o ka mālama ʻana me ka lāʻau lapaʻau.

Inā hoʻoholo ʻia ʻo Amoxiclav, pono e noʻonoʻo pono ka makahiki o ke keiki o ka mea maʻi i ka wā e kuhikuhi ana i ke ʻano o ka lāʻau a me ka maʻi.

Nā mea hoʻohālike Amoxiclav

Aia kekahi helu o ka hoʻohālikelike o kēia lāʻau lapaʻau. ʻO ke kumu kūʻai o nā mea kikoʻī, e mea mua, ma luna o ka mea hana. Aia nā analogues ma ke kūʻai aku ma mua o Amoxiclav. No nā poʻe maʻi e makemake ana i nā mea e hiki ke hoʻololi i kēia antibiotic, hāʻawi ka poʻe loea i kahi papa inoa o nā lāʻau lapaʻau. ʻO kēia ke ʻano Moxiclav, Co-Amoxiclav, Augmentin, Clavocin, Flemoklav, Medoclave, Baktoklav, Ranklav, AmovicombEia nō naʻe, he kauka kauka wale nō i kahakaha i kahi mea pihi. Hiki iā ʻoe ke koho i ka analogue haʻahaʻa i loko o nā papa, no ka laʻana, ʻo Augmentin. Hiki iā ʻoe ke koho i kahi kikowaena Lūkini, no ka hoʻohālike, ʻo Amoxicillin.

ʻO wai ka mea maikaʻi: Amoxiclav a Augmentin?

He aha ka mana o Amoxiclav a me Augmentin, he aha kaʻokoʻa o waena o kēia mau lāʻau? Aia nā mea ʻelua i mau pūnaehana like ʻole, ʻo ia hoʻi, ʻo ia ka mea like. Wahi a ia, aneane like ka hopena o ka lāʻau lapaʻau me ka hopena. ʻOkoʻa wale nō nā mea hana o kēia mau lāʻau.

Amoxiclav i ka wā hāpai a me ka lactation

Amoxiclav o ka hāpai ʻana hiki ke hoʻohana inā inā ʻoi aku ka hopena i manaʻo ʻia ma mua o ka hoʻopōʻino i ka wahine maʻi. Hoʻohana ʻia ka hoʻohana ʻana iā Amoxiclav i nā hoʻomaka mua o ka wā hāpai. ʻOi aku ka maikaʻi o 2 mau trimester a me 3 trimester, akā i ka manawa o kēia manawa, pono ke nānā pono ʻia ke ʻano o ka maʻi Amoxiclav i ka wā hapai. Amoxiclav hana waiū mai kākau, ʻoiai nā mea ikaika o ka lāʻau lapaʻau e komo i loko o ka waiū umauma.

Hōʻikeʻo Amoxiclav

Ma ke kaʻina kūkākūkā e kūkākūkā i ka lāʻau Amoxiclav, loiloi nā loiloi o nā kauka a me nā mea maʻi. Ua hoʻomaopopo ʻia he kūpono loa ka lāʻau lapaʻau i ka mālama ʻana i nā maʻi ʻōnaehana, a kūpono hoʻi i nā pākeke a me nā keiki. Hoʻomaopopo nā loiloi i ka hopena o ka lāʻau no ka sinusitis, no ka otitis media, no nā maʻi o ka huina. Ma ke kānāwai, lawe nā poʻe maʻi i nā papa o 875 mg + 125 mg, me ke ʻano kūpono, hiki koke mai ke kōkua o ke ʻano. Ma nā loiloi, ua hoʻomaopopo ʻia ma hope o kahi papa o ka mālama maʻi, e pono ke lawe i nā lāʻau lapaʻau e hoʻihoʻi i maʻamau microflora.

Hōʻike maikaʻi ʻia nā loiloi o Amoxiclav Kākau nā mākua he mea maʻalahi ia e hāʻawi i ka huahana i nā keiki, no ka mea he ʻono maikaʻi kēia a ʻike ʻia e nā keiki.

ʻO ke kumukūʻai Amoxiclav, kahi e kūʻai

Kūʻai Paola Amoxiclav 250 mg + 125 mg mau pahu 230 rubles no 15 pcs. E kūʻai i ka maʻi maʻi 500 mg + 125 mg hiki ke kūʻai ʻia ma 360 - 400 mau rubles no 15 mau pcs. Ehia na Pilille 875 mg + 125 mghilinaʻi i kahi o ke kūʻai aku. I ka awelika, ko lākou kumukūʻai he 420 - 470 mau rubles no 14 mau pcs.

Kūʻai Amoxiclav Quicktab 625 mg - mai 420 mau rubles no 14 mau pcs.

ʻO ke kumu kūʻai hoʻōla ʻO Amoxiclav no nā keiki - 290 mau rubles (100 ml).

Kūʻai Amoxiclav 1000 mg i Ukraine (Kiev, Kharkov, etc.) - mai 200 hryvnias no 14 mau ʻāpana.

ʻLoe a me ke kākele

Ua kuhikuhi ʻia nā ʻōmike Amoxiclav i nā mea maʻi ma mua o 12 mau makahiki a ke kaupaona ʻana ma mua o 40 kg.

No nā maʻi o ka hōʻoluʻolu i ka hōʻeha maʻalahi la i ka laoa i kauoha ia ai ma kahi in:

• 250 mg + 125 mg (375 mg) 3 mau manawa i ka lā.
• 500 mg + 125 mg (625 mg) mau manawa 2 i ka lā.

I nā maʻi koʻikoʻi, no ka maʻi hoʻi o ka hanu, ʻo Amoxiclav i loko o nā papa i kuhikuhi ʻia i loko o ka waihona ʻana:

• 500 mg + 125 mg (625 mg) 3 mau lā i ka lā.
• 875 mg + 125 mg (1000 mg) 2 mau manawa i ka lā.

ʻO ka dosis kiʻekiʻe loa o kēlā me kēia lā nā amoxicillin no nā pākeke he 6 g, clavulanic acid 600 mg.

ʻO ka dosis kiʻekiʻe loa o kēlā me kēia lā nā amoxicillin no nā keiki he 45 mg no ka kg o ka paona, clavulanic acid 10 mg pākeke.

Hiki ke lōʻihi ka lōʻihi o nā mea lapaʻau mai 5 a 14 lā. ʻEhia manawa e lawe ai i ka lāʻau lapaʻau e hoʻoholo ʻia e ke kauka.

No ka maʻi ʻana o ka puʻu waha, ʻo Amoxiclav i loko o kahi waihona o 375 mg e kuhikuhi ʻia i 3 mau manawa i ka lā, ma kahi ʻano o 625 mg - 2 mau lā i kahi lā no 5 lā.

Inā maʻi ka mea maʻi me ka huelo o ka kānana glomerular o 10 a 30 ml i hoʻokahi minuke, a laila ke kauoha ʻia ka lāʻau lapaʻau ma loko o kahi 625 mg me kahi mau hola o 12 mau hola, inā he maʻa ka hana ʻana ma lalo o 10 ml i hoʻokahi minuke, a laila hoʻemi ka nui o ka lawelawe ʻana i 1 mau manawa i ka lā.

I ka hala ʻole o ka urine, ʻo ka waena ma waena o ka lawe ʻana i ka manamana hope e pono ma kahi o 2 mau lā.

Nā hopena hopena

Ke lawe ʻia nei ka lāʻau lapaʻau, ʻike ʻia nā hopena kūpono ʻole i hōʻike ʻia, ka mea i hōʻike iki ʻia a hoʻokuʻu ʻia ma hope o ka pau ʻana o ka hopena.

• nele i ka momona, ka huehue, ka nausea, ka luaʻi
• nā pepeke
• hoʻonui eosinophils, lōʻihi prothrombin manawa, hoʻemi i nā koena koko a pau,
• nā hana nui, nā hopohopo, nā pilikia hiamoe, ke kīwī, nā hōʻeha, nā ʻōpū,
• huakai huakai, interstitial nephritis,
• manuahi, e komo pūkaukau.

E like me nā mea ikaika, amoxicillin a me clavulanic acid he ʻāpana o nā papa.

E like me nā mea hoʻohui aʻe, ka hoʻonohonoho ʻana o nā papa:

• silapia
• MCC
• ka leʻaleʻa talcum
• konekena stearate,
• polyvinylpyrrolidone,
• kahi sodium a ʻaihoe.

ʻO ka hoʻonohonoho ʻana o ke membrane film ka mea i ʻike i kēia mau haʻawina:

• polō i ka talcum:
• he 80,
• haniailahion,
• kēia ka pahuhopu
• titanium oxide
• triethyl citrate.

Pharmacology a me ka pharmacokinetics

Hōʻike ʻiaʻo Amoxiclav e kahi ākea ākea o ka hana antimicrobial. ʻO nā microorganism i kēia nā mea nānā aku i ka antibiotic:

• Aulaia,
• Hoʻokomo ʻia ʻo Yersinia enterocolitis,
• Melanie
• lailato
• E. coli
• Klebsiella
• gonococci
• muhukiha
• Shigella
• salmonella
• kolera vibrio,
• Proteus
• nā huakini
• pertussis wand
• pasteurella multicide,
• pepekean,
• ka brucella
• kampuniya ayuni,
• Holoi Ducrey,
• influenza hele wana
• ʻO ka helicobacter pylori,
• moraxella cataralis,
• peptococci,
• paulamala93
• pili
• preotella.

Ma hope o ka lawelawe waha, ua hōʻiliʻili ʻia nā mea ikaika ʻelua mai ke keʻa ʻana o ka digestive tract, ʻike ʻia ka ʻike ʻana ma hope o hoʻokahi hola. ʻAʻole ʻai i ka ʻai i ka hoʻopili ʻana o ka lāʻau lapaʻau.

Hoʻopokoke ka lāʻau lāʻau i ka nui o nā ʻili a me nā ʻōpala, hele i ka plasenta a hoʻopuni ʻia ma kahi liʻiliʻi me ka waiū umauma.

Hoʻomili ʻia ia i ka puʻuwai, excreted nui loa me nā keiki, ʻokoʻa paha ka hapalua ola mai 1 a 1.5 mau hola.

I nā pathal renal koʻikoʻi, hoʻonui ka hapalua o ke ola no ka amoxicillin i 7.5 hola, no ka clavulanic acid i nā hola 4.

Nā kuleana a me nā kūlana e waiho ai

Hiki ke kūʻai ʻia ka lāʻau lapaʻau me kahi papa lāʻau a nā kauka. Pono e mālama i nā paila i kahi kahi e hiki ʻole ai i nā keiki ke kiʻi iā lākou, ma ke kiʻekiʻe 25 максимумС.

(Waiho i kou loiloi ma nā manaʻo)

* - Kahi kumukūʻai o waena ma waena o nā mea kūʻai i ka manawa o ka nānā ʻana, ʻaʻole ia he hāʻawi i ka lehulehu

Nā papa ʻōlelo amoxiclav a me nā pauka - nā ʻōlelo no ka hoʻohana ʻana

No na keiki malalo o ke 12 mau makahiki - 40 mg no ka kilo o ka paona i kēlā me kēia lā.
No nā keiki nona ka momona ma mua o 40 kg, ua kuhikuhi ʻia ka lāʻau lapaʻau ma kahi o nā pākeke.

Ua kau ʻia nā makua Lawe ʻia nā papa he 375 mg i kēlā me kēia 8 hola i ka lā a pau, 625 mau papa i kēlā me kēia 12 mau hola. Ke koho ʻana i kahi lāʻau lapaʻau e mālama i nā maʻi ʻino loa, nā Doses o 625 mg i kēlā me kēia 8 hola, a 1000 paha i kēlā me kēia mau hola 12, ua hoʻohana ʻia.

Pono e hoʻomaopopo ʻia heʻokoʻa paha nā papa i ka hoʻohālikelike o nā mea ikaika. No laila, ʻaʻole hiki iā ʻoe ke kahakaha i kahi papa 625 mg (500 g o ka amoxicillin a me 125 g o ka clavulanic acid) me nā papa he 375 mg (250 g o ka amoxicillin a me 125 g o ka clavulanic acid).

Hoʻohana ʻia ma kēia ʻaoʻao e hoʻomaʻamaʻa i nā maʻi odontogenic. Loaʻa nā papa ʻai 375 mg i kēlā me kēia 8 mau hola, e hoʻohālikelike nei i ka uaki. 625 mg papa ma hope o 12 mau hola.

Inā pono, ʻo ka hoʻohana ʻana i nā lāʻau lapaʻau no ka mālamaʻana i nā mea maʻi me ka maʻi maʻi e pono ai e noʻonoʻo i ka ʻike o ka mea hana i loko o ka urine. ʻO nā mea maʻi me nā maʻi pūlū e pono ai e kiaʻi mau i kā lākou hana.

Hoʻopili no ka pēpē no na keiki ame na keiki a hiki i ka 3 malama. ^ E Ha yM. Hoʻopiʻi ʻia nā Dosis me ka hoʻohana ʻana i kahi pipette kūhaʻi kūikawā a i ʻole c. Ka liʻiliʻi - 30 mg o ka amoxicillin pākeke o ke paona, ʻelua mau lā i kēlā lā.

No na keiki mamua o ekolu malama no nā maʻi hōʻemi a me ka maʻalahi - 20 mg / kg o ke koʻikoʻi o ke kino, a no nā maʻi maʻi nui - 40 mg / kg. Hoʻohana ʻia ʻo ka hopena ʻelua ma ka mālama ʻana i nā maʻi hohonu - ka mumū o ka pepeiao waena, sinusitis, bronchitis, pneumonia. Hoʻopili ʻia kahi ʻōlelo aʻoaʻo i kēia lāʻau lapaʻau, aia ma nā papa hana kūikawā e hiki ai iā ʻoe ke helu pololei i nā ʻano pono o ka lāʻau i nā keiki.

ʻO ka paona ʻana loa i kēlā me kēia lā no ka amoxicillin no nā keiki he 45 mg / kg o ke kaumaha, no nā pākeke - 6 grama. Hiki ke lawe ʻia ka waikawa Clavulanic i kēlā lā i kēia lā ʻaʻole iʻoi aku ma mua o 600 mg no nā pākeke a me 10 mg / kg no nā keiki.

ʻO ka wehewehe ʻana i nā palapala hoʻokuʻu

Loaʻa kēia lāʻau lapaʻau i ke ʻano o nā papa panee i ʻulaʻula a i ʻole ʻulaʻula-ʻula. Aia nā papa i kahi kūlike o biconvex.

ʻO ka papa 625 mg e loaʻa ana i ka 500 mg o ka amoxicillin trihydrate me 125 mg o ka clavulanic acid (paʻakai paʻakai).

Hiki ke hōʻili ʻia nā papa ma nā kēla palaki (15 mau papa i kēlā) a i ʻole bli paha alumini o 5 a 7 mau ʻāpana paha.

Ua hoʻopaʻa ʻia nā papa o 1000 mg, he ʻano oblong me nā kihi beveled. Ma luna o lākou, ma ka lima hoʻokahi, ua kau ʻia kahi ʻano hōʻailona o "AMS", ma kekahi - - 875/125 ". Hoʻopili lākou iā 875 mg o ka antibiotic a me ka 125 mg o ka acid clavulanic.

Ka kuʻikahi me nā lāʻau lapaʻau ʻē aʻe

• He pono ʻole ia e hoʻohana like me Amoxiclav a me nā hoʻomākaukau o nā anticoagulants kūlike. Hiki i kēia ke kumu i ka hoʻonui ʻana o ka manawa prothrombin.
• ʻO ka pilina ʻo Amoxiclav a me allopurinol e hōʻeha i kahi hanana o ka exanthema.
• Hoʻonui ka Amoxiclav i ka lilo o ka metatrexate.
• ʻAʻole hiki iā ʻoe ke hoʻohana i ka amoxicillin a me nā rifampicin - he mau antagonis kēia, a hoʻohui ʻia ke ʻano nāwaliwali o ka hopena antibacterial o lāua ʻelua.
• ʻAʻole pono e ʻōlohelohe ʻia ʻo Amoxiclav i ka tetracyclines a me nā macrolides (ʻo kēia nā antibiotika o ka bacteriostatic), me ka sulfonamides ma muli o kahi emi o ka hopena o kēia lāʻau lapaʻau.
• ʻO ka lawe ʻana iā Amoxiclav e hōʻemi i ka hopena o nā mea contraceptives i nā papa.

Hōʻike nā kauka i nā kauka

ʻO Anna Leonidovna, kaukaʻi, Vitebsk. ʻOi aku ka maikaʻi o Amoxiclav i ka mālamaʻana i nā maʻi ʻeha o ka hanu ma mua o kona hoʻohālikelike, amoxicillin. Ke kuhikuhi nei wau i kahi papa o 5 mau lā, ma hope o ke kauoha ʻana e lawe i nā lāʻau lapaʻau e hoʻihoʻi ana i ka microflora.

ʻO Veronika Pavlovna, urologist. M. Kryvyi Rih. He hopena maikaʻi kēia lāʻau lapaʻau i nā maʻi neʻe o ka huelo o ka genital tract. ʻAʻole hiki iā ia ke hāʻawi i nā hopena hopena, i ka manawa like wau i kākau ai i nā lāʻau antifungal, ma hope o ka lawe ʻana i nā probiotics e hoʻihoʻi i ka microflora maʻamau.

Andrei Evgenievich, Kauka ENT, Polotsk. ʻO ka hoʻohana ʻana i kēia lāʻau lapaʻau ma ka inake hiki iā ʻoe ke hoʻopau koke i ka hōʻike ʻana o nā maʻi koʻikoʻi a me ke ʻano o nā kino ENT. Hoʻomaʻamaʻa maikaʻi ka lāʻau lapaʻau i ka mumū o ka pepeiao waena. Eia kekahi, lawe nā mea maʻi i ka suspension hua maikaʻi.

ʻO ka wehewehe ʻana i ka lāʻau lapaʻau

ʻO Amoxiclav i ʻelua mau papa nui. ʻO ka mea mua, he penicillin semisynthetic kēia - amoxicillin, a me ka acid clavulanic. Loaʻa i kēlā me kēia me kāna hana ponoʻī. ʻO ka Amoxicillin ma waena o nā kuʻuna, eia naʻe, ʻaʻole i loaʻa i nā hopena antibacterial ka waʻa clavulanic. Pehea la kona kumu?

E like me kāu e ʻike ai, ʻo nā penicillins kekahi o nā lāʻau mua i loaʻa i ka waenakonu o ke kenekulia hope. I loko o kā lākou hoʻohanaʻana, ua hōʻike lākou i ko lākou kūlana kiʻekiʻe. Akā i ka manawa like, ua nui nā huikala na lākou e hoʻomau i ka pale aku iā lākou. Pehea ka hana ʻana o ka maʻi bakteria e pili ana i ka antibiotics?

Hoʻokumu ka Amoxicillin i ka membrane o nā pona o nā huakini, ka mea e hoʻopili ai i kekahi o nā huina o ka huina. Ma muli o kēia, ua nalowale ka paia o ka pā i ka ikaika a luku ʻia a make ka maʻi bacterium. Eia nō naʻe, hoʻomaka kekahi mau ʻano o nā huakini e hana i nā mea kūikawā - beta-lactamases, kahi e pani ai i ka hana o nā antibiotics. No laila, liloʻo amoxicillin i ka hapa loa i ka hapanui.

Hoʻolālā maoli ʻia ka Clavulanic acid e hakakā i ka beta-lactamases. Ma ka mākaʻi ʻana i ka amoxicillin, hana ia i nā molekikinika e pili ana i ka beta-lactamases. Hōʻike ʻia kēia hopena e pili ana i ka hapa nui o nā ʻano o ka beta-lactamases i hoʻohālikelike ʻia e nā bacteria.

No laila, ʻo ka hui pūʻana o ka amoxicillin a me clavulanic acid i kahi ākea ākea e pili ana i ka hana antibacterial ma mua o ka amoxicillin maʻemaʻe. Inā hiki i ka amoxicillin ke hoʻopilikia wale i ka helu helu o nā huakini i hiki ʻole ke hoʻopuka i ka beta-lactamases, a laila ʻo amoxicillin, i hui pū ʻia me ka clavulanic acid, e kūlike ana i ka hapa nui o nā huakini e hōʻeha ai i nā maʻi maʻi. I waena o nā huaʻai e hiki ai iā Amoxiclav ke hōʻoki, aia nā lua-gram maikaʻi a me nā pehu.

ʻO nā ʻano nui o nā huakini e pili ana i ka Amoxiclav:

• Aulaia,
• Melanie
• Shigella
• Klebsiella
• ka brucella
• eokokola
• Hoʻokomo Helicobacter
• pili
• hiloi hemophilic,
• salmonella
• Proteus.

I nā kūmole kūpaʻa Amoxiclav:

• enterobacter
• ʻO nā ʻōhule
• chlamydia
• mycoplasmas
• legionella
• ʻO Yersinia

a o kekahi.

Lapaʻau lāʻau

ʻO Amoxicillin kahi penicillin semi-synthetic e hana ana i nā microorganism mua-gram a me ka gram-maikaʻi. Hoʻopili ia i ka biosynthesis o peptidoglycan, he māhele o ka ʻāpana o ka paia o nā pā cell bacterial. ʻO ka hoʻohaʻahaʻa ʻana i ka hana o peptidoglycan e hōʻemi i ka ikaika o nā paia o nā cell, kahi i alakaʻi ai i ka lysis a me ka make o nā pūpuna o nā microorganism pathogenic. I ka manawa like, ua kūpono ke amoxicillin i ka hana a beta-lactamases, ka mea e luku ai ia ia, no laila ʻaʻole i komo nā kikoʻī o nā hana antibacterial i ka microorganism synthesizing o kēia enzyme.

ʻO Clavulanic acid he beta-lactamase inhibitor, ke ʻano o ka mea e like me ka penicillin. Hiki iā ia ke hana i ka nui o ka beta-lactamases, e hana ana i nā microorganism me ka pale ʻana i ka cephalosporins a me nā penicillins. Ua hōʻoia ʻia ka hana kūpono o ka acid clavulanic e pili ana i ka plasmid beta-lactamases, kahi e hoʻoholo pinepine ai i ka kūʻē o nā maʻi i nā antibiotics, ua hōʻike ʻia. Eia naʻe, ʻaʻole hana ka mea i ka type chromosome beta-lactamases i pale ʻole ʻia e ka clavulanic acid.

ʻO ka nohoʻana o ka clavulanic acid ma Amoxiclav e hiki ai i ka pale aku i ka luku ʻia o nā amoxicillin e nā enzymes kūikawā - beta-lactamases - a hoʻonui i ka kiko o ka hana antibacterial o amoxicillin.

ʻO nā haʻawina hauka ma vitro e hōʻike i ka naʻau kiʻekiʻe i ka hana a Amoxiclav o nā microorganism e hiki mai ana:

• anaerobes gram-negatif: nā ʻano mea he gen Prevotella, Bacteroides fragilis, subspecies of the genus Bacteroides, varieties of the genus Porphyromonas, varieties of the genus Capnocytophaga, varieties of the genus Fusobacterium, Fusobacterium nucleatum, Eikenella corrodens,
• anaerobes gram-positive: species of genus Peptostreptococcus, Peptostreptococcus magnus, Peptostreptococcus micros, Peptococcus niger, species of the genus Clostridium,
• aerobes gram-negative: Vibrio cholerae, Bordetella pertussis, Pasteurella multocida, Haemophilus influenza, Neisseria gonorrhoeae, Moraxella catarrhalis, Helicobacter pylori,
• aerobes gram-positive: coagulase-negative staphylococci (e hōʻike ana i ka ʻike ʻana i ka methicillin), Staphylococcus saprophyticus (kūlia pili i ka methicillin), Staphylococcus aureus (kūlia pili i ka methicillin), Bacillus anthracis, Streptococococococococee , ʻO Nocardia asteroids, Listeria monocytogenes,
• ʻO kekahi: Treponema pallidum, Leptospira icterohaemorrhagiae, Borrelia burgdorferi.

Hōʻike ʻia nā microorganisms e like me ka loaʻa ʻana o ka pale i nā mea ikaika o Amoxiclav:

• aerobes gram-positive: streptococci o ka hui ʻo Viridans, Streptococcus pneumoniae, Enterococcus faecium, nā mea pili o ka iwi Corynebacterium,
• Aerobes Gram-negative: bacteria o ka huaʻōlelo Shigella, Escherichia coli, nā huaʻai o ka huaʻōlelo Salmonella, nā huaʻala o nā huaʻōlelo Klebsiella, Klebsiella pneumoniae (nā haʻawina neʻe hōʻoia e pili ana i ka hopena o nā mea ikaika a ʻAoxoxlav e pili ana i kēia microorganism, ʻo nā mākela o ka synthesize beta-lactamases), Klebsiella axus , Proteus vulgaris, Proteus mirabilis.

Hōʻike nā microorganism i kēia kūlohelohe kūlohelohe i ka hui pū ʻana o ka amoxicillin a me ka clavulanic acid:

• aerobes gram-negative: bacteria o ka huaʻala Acinetobacter, Yersinia enterocolitica, Citrobacter freundii, Stenotrophomonas maltophilia, Enterobacter bacteria, Pseudomonas bacteria, Hafnia alvei, Serratia genus bacteria, Legionella pneumophila bacteria, Providencia morganella morganella bacteria
• nā mea ʻē aʻe: nā bacteria o ka huaʻōlelo Mycoplasma, Chlamydophila psittaci, Chlamydophila pneumoniae, nā manawa o nā huaʻōlelo Chlamydia, Coxiella burnetii.

ʻO ka hoʻowali ʻana o nā maʻi i ka monotherapy me ka amoxicillin pinepine i ka like me ka like me ka hui ʻana o ka amoxicillin a me ka clavulanic acid.

Nā Hōʻike Hoʻomaʻi

Victoria, Dnipropetrovsk. Hoʻohana ʻia e ke kauka no ka mālama ʻana i nā tonsillitis. ʻIke 5 lā lā. Ua hoʻomaka ka antibiotic i ka lā 3 o ka maʻi. Ua hala ka maʻi i kekahi hapakolu. Ua ʻeha koʻu ʻeha. Aia ka make ʻana, i hala i loko o ʻelua lā, ma hope o ka hoʻomaka ʻana e lawe i ka probiotics e hoʻihoʻi i ka microflora.

ʻO Alexandra, ke kūlanakauhale o Lugansk. Ua kuhikuhi ʻia kēia lāʻau lapaʻau e nā kauka e mālama i ka pyelonephritis. ʻO ke papa lā he 7 lā. ʻO nā lā 3 mau lā ma mua - a laila helu. ʻAkole nui nā injections. Eia naʻe, hoʻomaka ka hoʻomaikaʻi a puni ka lā ʻehā. ʻAʻohe hopena hopena. Aia kēlā malo maloʻo.

Tamara, ke kūlanakauhale o Boyarka. Ua paʻi mai lākou iaʻu i kēia lāʻau lapaʻau no ka mālama ʻana i ka maʻi gynecological. He mea ʻeha loa loa, noho mau ka bruises ma ka wahi o ka maʻi ʻomaʻi pūnaewele. Eia naʻe, ma hope o ka hebedoma, ʻaʻohe wahi i waiho ʻia i loko o nā kaomi mai ka pathogen.

Hoike hōkeo

Inā hoʻohana ʻia ka lāʻau lapaʻau no ka manawa lōʻihi, pono ia e nānā i nā hana o nā ate, nā hana aniani i nā maʻi o nā maʻi. Inā hoʻokomo ka mea maʻi i ka hana renal, pono ia e hoʻoponopono i ka hopena a hoʻonui paha i ka manawa ma waena o nā hopena o ka lāʻau. ʻOi aku ka maikaʻi ke lawe i ka lāʻau lapaʻau me ka meaʻai. I ka hihia o ka superinfection (ke nānā ʻana o ka insensitive o ka microflora i kēia antibiotic), pono e hoʻololi i ka lāʻau. Ma muli o ka hiki o ka hopena cross-allergic me cephalosporins i nā poʻe maʻi e pili ana i nā penicillins, pono ʻole e hoʻohana i kēia mau lāʻau maʻi i ka manawa like.

Ke lawe nei i ka lāʻau lapaʻau, pono ʻoe e inu i ka nui o ka wai o ka wai no ka paleʻana i ka hoʻokumu ʻana o nā crystals amoxicillin i loko o ka urine.

E makaʻala ʻoe i ka hele ʻana o nā kaha kiʻekiʻe o kahi lāʻau lapaʻau i loko o ke kino e hoʻonāukiuki i ka hopena hewa-maikaʻi i loko o ka urine glucose (inā hoʻohana ʻo Benedict a i ʻole ka hopena a Fleming e hoʻohana ai e hoʻoholo ai). Hāʻawi nā hopena kūpono i kēia hihia e hoʻohana i ka hoʻohana ʻana i ka hoʻonāʻana o ka enzymatic me ka glucosidase.

Ma muli o nā hopena ʻona mai ka ʻōnaehana o ka nūnū e hiki ke hoʻohana ʻia i ka lāʻau lapaʻau, pono pono e hoʻokau pono i nā kaʻa (kaʻa) a i ʻole e hana i nā hana e koi ai i ka hoʻonui ʻia, wikiwiki a me ka nānā.

Hoʻokuʻu ʻia ma ke kau inoa.

Nā papa hana a me nā ʻōnaehana no ka hoʻopiʻi ʻana i ka waha

Hoʻomaopopo ka regimen o ka lāʻau a me ka lōʻihi o ka mālama ʻana i nā ʻano o ka nui o ka maʻi, ka makahiki, ka hana a ka mea maʻi a me ke kaumaha o ke kino. I nā papa a me nā hana hoʻokauwila, ʻōlelo ʻia ʻo Amoxiclav e lawe pū me nā meaʻai, ʻo ia ka mea e hōʻemi i ka hopena o nā hopena o ka ʻaoʻao mai ka hoʻopili ʻana.

ʻO ka papa maʻamau o ka mālama ʻana mai ka 5-14 lā. Hiki ke hoʻokō ʻia ka mālama ʻana ma hope o kahi hoʻopaʻa loiloi lua.

ʻO ka regimen dosis papa ʻia no nā papa Amoxiclav no nā keiki ma lalo o 12 mau makahiki he 40 mg / kg i kēlā me kēia lā, ka mea i hoʻokaʻawale ʻia i 3 mau pona. ʻO nā keiki me ke kaumaha o ke kino ʻoi aku ma mua o 40 kg e hōʻike ʻia ana nā dosages no nā pākeke. No nā keiki i lalo o 6 mau makahiki aku, ʻoi aku ka maikaʻi o ka hoʻohana ʻana iā Amoxiclav.

ʻElua mau hoʻolālā no ka lawe ʻana iā Amoxiclav i nā pākeke me ka maʻi maʻalahi i kahi maʻalahi.

• ʻO kēlā me kēia mau hola 8, 1 papa 250 + 125 mg,
• ʻO kēlā me kēia mau hola 12, 1 papa 500 + 125 mg.

E kūlike i ke kua o nā maʻi koʻikoʻi a me nā maʻi o ka hanu, pono ʻia ke pākaukau 1 papa o 500 + 125 mg i kēlā me kēia 8 mau hola a i ʻole 1 papa paha 875 + 125 mg i kēlā me kēia mau hola 12.

Me nā maʻi odontogenic, ka hoʻomalu ʻana o ka papa papa 1 o Amoxiclav 250 + 125 mg i kēlā me kēia 8 hola a i ʻole 1 papa paha o 500 + 125 mg i kēlā me kēia mau hola 12 e hōʻike ʻia no nā lā 5.

Ua hoʻonohonoho ʻia ʻo Amoxiclav i nā keiki hou a me nā keiki a hiki i 3 mau mahina ma ke ʻano o ka hoʻokuʻu ʻana i ka nui o 30 mg / kg i kēlā me kēia lā (e like me amoxicillin). Lawe ʻia ka lāʻau lapaʻau i kēlā me kēia 12 mau hola. E hoʻokō me ka dosage, hoʻohana i ka pipette dosage i hāʻawi ʻia me ka pā uila

ʻO ka dosage i kēlā me kēia lā o Amoxiclav no nā keiki he mau makahiki ma mua o 3 mau mahina:

• Me ka hōʻoluʻolu a me ka hōʻeha o ka maʻi - mai 20 mg / kg i kēlā me kēia lā,
• Ma nā maʻi koʻikoʻi a me ka mālama ʻana i nā maʻi o ka ʻōpū o ka hanu haʻahaʻa, otitis media, sinusitis - a hiki i 40 mg / kg (amoxicillin) i kēlā me kēia lā.

Pono e noʻonoʻo i ka wā e helu ana i nā hewa, ʻaʻole pono e hilinaʻi kekahi i ka makahiki o ke keiki, akā ma ke koʻokoʻo o kona kino a me ka paʻakikī o ka papa o ka maʻi.

ʻOka hoʻonā ʻana

ʻO Amoxiclav i ke ʻano o ka hopena no ka inikua ke mālama kūʻokoʻa ʻia i loko o ka intravenously.

No nā keiki ma lalo o 3 mau mahina, e kau ʻia ke ʻano ma kēia ʻike.

• kaupaona kino ma mua o 4 kg: ke lawelawe nei ʻo Amoxiclav i loko o kahi waihona o 30 mg / kg (e noʻonoʻo ana i ka hoʻololi ʻana i ka lāʻau holoʻokoʻa holoʻokoʻa) i kēlā me kēia mau hola 12,
• kaupaona kino ma luna o 4 kg: ke kāʻei ʻia ʻo Amoxiclav ma ke ʻano o 30 mg / kg (e noʻonoʻo ana i ka hoʻololi ʻana i ka lāʻau holoʻokoʻa) ma kēlā me kēia 8 mau hola.

ʻO nā keiki ʻaʻole i hiki i ka 3 mau makahiki o ke koikoi ʻana, pono e hoʻolōʻihi ʻia ka maʻi i ka infusion mālie no 30-40 mau minuke.

No nā keiki ʻaʻole ʻoi aku ka momona o ke kino ma mua o 40 kg, ua koho ʻia ke kaha me ka noʻonoʻo ʻana i ke kaumaha o ke kino.

No nā keiki mai 3 mau mahina a hiki i 12 mau makahiki, ke mālama ʻia ka lāʻau lapaʻau ma ka waihona me 30 mg / kg kino kino (ma nā ʻōlelo o ke ʻano holoʻokoʻa) i kēlā me kēia 8 mau hola, a i ka pōʻino loa, ʻo kēlā me kēia 6 mau hola.

I nā keiki me nā maʻi homaʻiʻole o ka renal, ʻike ʻia kahi hoʻoponopono ʻana ma muli o ka nui o ka nui o ka dosis i pau ai ka manaxicillin. Inā ma kēlā mau mea maʻi hiki i kahi hana hoʻopihapiha hana ma mua o 30 ml / min, he koho ka hoʻololi ʻana. I kekahi mau mea'ē aʻe, i nā keiki i loaʻa ke kaumaha o ke kino ʻaʻole i ka 40 kg, ua hoʻohana ʻia ka hoʻohana ʻana iā Amoxiclav i kēia mau kākana aʻe:

• KK 10-30 ml / min: 25 mg / 5 mg no 1 kg o ka paona kino i kēlā me kēia 12 hola,
• CC ma mua o 10 ml / min: 25 mg / 5 mg no 1 kg o ka paona kino i kēlā me kēia 24 hola,
• hemodialysis: 25 mg / 5 mg no 1 kg o ka paona o kēlā me kēia 24 hola i hui pū ʻia me kahi dosis hou o 12.5 mg / 2,5 mg no 1 kg o ke kino o ke kino ma ka hopena o ka hui dialysis (pili i ka hoʻemi ʻana o ka ʻaila clavulanic acid a me amoxicillin i loko. serum koko).

ʻO kēlā me kēia 30 mg o ka lāʻau lapaʻau ka 25 mg o ka amoxicillin a me 5 mg o ka clavulanic acid.

No nā pākeke a me nā keiki ma mua o 12 mau makahiki a i kaupaona paha ma mua o 40 kg, ua mālama ʻia ʻo Amoxiclav i loko o kahi waihona o 1200 mg o ka lāʻau (1000 mg + 200 mg) i kēlā me kēia mau hola 8, a i ke ʻano o kahi papa maʻi o kahi maʻi maʻi - i kēlā me kēia 6 mau hola.

Ua ʻōmapa ʻia ʻo Amoxiclav no ka hōʻea ʻana o ka haukapila ma kahi prophylactic dosis, ʻo ia ka mea maʻamau ma ka 1200 mg me ka hoʻokomo ʻana o ka anesthesia i nā hihia kahi i pau ai ka hana ma lalo o 2 mau hola. Me nā wawaʻi o ka lōʻihi o ka wā, loaʻa ka mea maʻi i ka lāʻau lapaʻau ma loko o kahi hapa o 1200 mg a hiki i ka 4 mau manawa no ka 1 lā.

I ka poʻe maʻi e hōʻeha nei i ka hina ʻana o ka renal, e hoʻoponopono ʻia ka nui o ka manawa a me / a i ʻole manawa i waena o ka hoʻokele ʻana o Amoxiclav e pili ana i ka pae o ka hana renal impaired i like me nā ʻōlelo i lalo iho nei.

• CC ma mua o 30 ml / min: ʻaʻohe pono no ka hoʻoponopono hoʻoponopono ʻana,
• KK 10-30 ml / min: ʻo ka mua mua loa he 1200 mg (1000 mg + 200 mg), ma hope o ka lā e mālama ʻia ai ka lāʻau lapaʻau ma loko o kahi waiʻeono o 600 mg (500 mg + 100 mg) i kēlā me kēia mau hola 12.
• CC ma mua o 10 ml / min: ʻo ka mua o ka papa i ka 1200 mg (1000 mg + 200 mg), ma hope o ka lā e mālama ʻia ai ka lāʻau lapaʻau ma loko o kahi waiʻeono o 600 mg (500 mg + 100 mg) kēlā me kēia 24 hola,
• anuria: ʻo ka papalū ma waena o nā inikua o ka lāʻau lapaʻau e pono e hoʻonui i ka 48 mau hola a keu paha.

Mai ka manawa o ke kaʻina hemodialysis a hiki i ka 85% o ka hoʻomakeke ʻia o Amoxiclav e hoʻoneʻe ʻia, ma ka hopena o kēlā me kēia hālāwai, ke ʻano o ka maʻi maʻamau no ka hoʻonā ʻana. Me ka dialysis peritoneal, ʻaʻohe pono o ka hoʻoponopono hoʻoponopono ʻia.

ʻO ka lōʻihi o ka papa o ka mālamaʻana mai ka 5 a 14 mau lā (ʻo ke kauka hele wale nō e hiki ke hoʻoholo i kona lōʻihi). Me ka hoʻohaʻahaʻa ʻana i ka uha o ka ʻike, hoʻolōʻihi ʻia ka hoʻololi i nā ʻano waha o Amoxiclav ma ke ʻano he hoʻomau mau o ka hopena.

I ka hoʻomākaukau ʻana i ka hoʻonā hoʻonāʻau, nā mākau o nā ipu i ka nui o 600 mg (500 mg + 100 mg) e hoʻoheheʻe ʻia ma 10 ml o ka wai no ka maʻi ʻaina, a ma ka nui o 1200 mg (1000 mg + 200 mg) i 20 ml o ka wai no ka inikini (ʻaʻole i aʻo ʻia kēia mau kaha. ʻoi aku) Hoʻōhoihoi pinepine ʻia ka lāʻau lapaʻau (ma luna o nā minuke 3-4), a pono ke lawe ʻia ka hoʻomaka i loko o 20 mau minuke ma hope o ka hoʻomākaukau o ka hoʻonā.

Hiki ke hoʻohana ʻia ka hopenaʻo Amoxiclav no ka infusion intravenous. Ma kēia hihia, nā ʻōnaʻi i hoʻomākaukau ʻia e loaʻa ana he 1200 mg (1000 mg + 200 mg) a i ka 600 mg (500 mg + 100 mg) o ka lāʻau lapaʻau ka laula hou i ka 100 ml a i ʻole 50 ml o ka hoʻonāʻaupī. ʻO ka lōʻihi o ka infusion e hiki i ka 30-40 mau minuke.

ʻO ka hoʻohana ʻana o nā wai aʻe e hiki mai ana i loko o nā polu i ʻōlelo ʻia ai e hiki ai iā ʻoe ke mālama i ka hoʻoulu ʻia ʻana o nā amoxicillin i loko o nā hoʻonā infusion. Nā loli o ko lākou mau manawa a me ka:

• no ka wai no ka paʻi: 4 mau hola ma 25 ° C a me 8 mau hola ma 5 ° C,
• no nā hopena o ka sodium klorida a me ka calcium chloride no ka hoʻopili intravenous: 3 mau hola ma 25 ° C,
• no ka hopena o ka lōlani no ka lactate no ka hoʻopili intravenous: 3 mau hola ma 25 ° C,
• no ka sodium chloride 0.9% no ka infravenous infusion: 4 mau hola ma 25 ° C a me 8 mau hola ma 5 ° C.

ʻAʻole pono ke hui pū ʻia nā ʻōmole Amoxiclav me ka hopena o ka sodium bicarbonate, dextran a i ʻole ka dextrose. ʻO nā hoʻoponopono kūlohelohe wale nō ia e hoʻokele ʻia ai. ʻAʻole hōʻemi ʻia ka hopena mākaukau.

Hoʻokomo i ka hiki ke lawe i nā kaʻa a me nā mīkini paʻakikī

Inā i ka wā o ka mālamaʻana me ka lāʻau lapaʻau, ʻike ʻia ka mea maʻi i nā hopena kūpono ʻole mai ke kikowaena kūloko o ke kikowaena (no ka laʻana, ka hoʻohuli a i ʻole ka maʻi lahilahi.

ʻŌpū a me ka lactation

I nā hoʻokolohua holoholona, ​​ʻaʻole i hōʻoia ʻia ka hopena o ka lawe ʻana iā Amoxiclav i ka wā hāpai a me ka hopena o ka lāʻau lapaʻau ma ka hoʻomohala ʻana i ka hanana o ka pūpū. I loko o kahi haʻawina hoʻokahi e pili ana i ka wahine me ka wā o ka hakahaka o nā membni amniotic, ua ʻike ʻia ka hoʻohana ʻana o prophylactic i ka hui pū ʻana o ka amoxicillin a me ka acid clavulanic e hoʻonui i ka hiki o ka necrotizing enterocolitis i loko o nā mea hou.

I ka wā hapai a me ka lactation, ke hoʻohana pono ʻia nei ka hoʻohana ʻana iā Amoxiclav inā hiki paha i ka nui o ka pono o ka mālama ʻana i ka makuahine me ka nui o ka hopena e hiki mai ai i ke ola o ke kīpē a me ke keiki. ʻO Clavulanic waikawa a me ka amoxicillin i loko o nā liʻiliʻi liʻiliʻi e hoʻoholo ʻia i loko o ka waiū umauma. I nā pēpē i hoʻonāukiuki, maʻi palapa, hoʻonaninani, kandidiasis o nā membrane mucous o ka waha waha e ulu, no laila, pono pono ke mālama me ka lāʻau lapaʻau, e aʻo ʻia e pani i ka ʻōpū.

I ka hihia o ka hana renal hemaʻa

ʻO ka poʻe maʻi me ka hiki ʻole o ka renal modulate (CC like mai 10 a 30 ml / min) ke kuhikuhi ʻia e lawe i ka papa Amoxiclav 1 (e pā ana i 500 mg / 125 mg a i ʻole 250 mg / 125 mg ma muli o ka nui o ka maʻi) i kēlā me kēia hola 12, a me pilikia hōʻeha maikaʻi loa (CC ma mua o 10 ml / min) - 1 papa (nui o ka 500 mg / 125 mg a i ʻole 250 mg / 125 mg ma muli o ka nui o ka maʻi) i kēlā me kēia 24 hola.

ʻO ka papa mua o ka hoʻonā no ka hoʻokele intravenous me CC o 10-30 ml / min ʻo 1000 mg / 200 mg, a laila 500 mg / 100 mg i kēlā me kēia mau hola 12. Me CC me lalo o 10 ml / min, ka mua o ka hopena o ka hoʻonā no ka hoʻokō intravenous ʻo 1000 mg / 200 mg, a laila 500 mg / 100 mg no kēlā me 24 hola.

I ka anuria, ua hoʻonui ke kikowaena ma waena o nā pona o Amoxiclav i 48 mau hola a keu paha.

Hoʻohui nūhou

ʻO ka komo ʻana o ka waikawa ascorbic me Amoxiclav e hoʻonui i ka hoʻopili ʻana o kāna mau mea ikaika, a me ka hoʻokomo o aminoglycosides, antacids, laxatives, glucosamine - e hōʻemi ana i ko lākou komo ʻana. ʻO ka hoʻohana ʻana i nā lāʻau anti-inflammatory non-steroidal (NSAIDs), diuretics, phenylbutazone, allopurinol a me nā lāʻau ʻē aʻe e pāpā aku i ka huna ʻana o tubular (probenecid) e hoʻonui i ka pae o ka amoxicillin i ke kino (clavulanic acid ma ka hoʻopā maoli ʻia ma o ka filomation glomerular). ʻO ka hui pū ʻana o Amoxiclav a me probenecid hiki ke piʻi i ka hoʻonui o ka hoʻomau i ke koko a me ka ʻaina o ka amoxicillin, akā ʻaʻole ia o ka clavulanic acid, no laila ke pāpā ʻia ka hoʻohana like ʻana o nā lāʻau lapaʻau.

Hoʻohui i ka hui pūʻana o ka amoxicillin, clavulanic acid a me methotrexate i nā mea momona o methotrexate. ʻO ka hoʻohanaʻana i ka lāʻau lapaʻau me ka allopurinol hiki ke hoʻonāukiuki i ka hoʻomohala ʻana i nā ʻano maʻi alaka. ʻAʻole ia e kuhikuhi i ke kuhikuhi iā Amoxiclav i hui pū me disulfiram.

ʻO ka hui pū ʻana o ka amoxicillin a me ka waikawa clavulanic e hōʻemi ana i ka pono o nā lāʻau lapaʻau e alakaʻi ana i ka hana metabolism i ka hoʻokumu ʻana o ka para-aminobenzoic acid, a i ka wā e lawe ʻia me ka estrinyol estradiol, ʻo ka hopena o ka hoʻomohala ʻana i ka puhaka "hōʻalo" i piʻi.

Ma ka palapala, he nui nā hōʻike e pili ana i ka hoʻonui ʻana i ka ratio o ka maʻamau maʻamau (INR) i nā poʻe maʻi me ka hoʻomohala ʻana o ka amoxicillin a me warfarin a acenocoumarol. Inā pono e hoʻohui i ka Amoxiclav me anticoagulants, mālama pono ʻia ka nānā ʻana i ka INR a i ka manawa prothrombin i ka wā e hoʻokaʻawale a hoʻomaka ʻia ka mālama ʻana me ka lāʻau lapaʻau, ʻoiai ka mea e hoʻoponopono ʻia ai nā ʻaina o nā anticoagulants e lawe pono ʻia.

ʻO ke kākoʻo ʻana o ka amoxicillin / clavulanic acid me ka rifampicin hiki ke alakaʻi i kahiʻano palupalu o ka hopena antibacterial. ʻAʻole ʻōlelo ʻo Amoxiclav i ka wā hoʻokahi i hui pū me ka antibiotika bacteriostatic (tetracyclines, macrolides) a me sulfonamides ma muli o ka emi o ka hopena o ka hopena o ka asidonexicillin / clavulanic.

ʻO ka lawe ʻana i ka lāʻau lapaʻau e hōʻemi i ka hopena o nā moʻo kūlohelohe waha. I loko o nā mea maʻi e lawe i ka mycophenolate mofetil, ma hope o ka hoʻomaka ʻana me ka hoʻohana ʻana iā Amoxiclav, aia ke emi ʻana o ka haʻawina o ka metabolite ikaika i loko o ke kino - ka waikawa mycophenolic - ma mua o ka lawe ʻana i ka hā aʻe o ka lāʻau e ka mea e pili ana i ka 50%. ʻAʻole hiki i ka loli ʻana ona ke kūlike maoli i nā loli maʻamau i ka hoʻolaha ʻana o kēia metabolite.

ʻO nā mea hoʻohaumaha Amoxiclav:

• E ke ʻano ikaika - Bactoclav, Clamosar, Arlet, Panklav, Medoklav, Liklav, Augmentin, Rapiklav, Fibell, Ekoklav, Amovikomb, Amoksivan,
• Ma ka hana o ka hana - Libacil, Oxamp, Santaz, Ampioks, Tazotsin, Timentin, Sulacillin, Ampisid.

He kumukūʻai Amoxiclav i nā lāʻau lapaʻau

ʻO ke kumukūʻai kūpono o Amoxiclav i ke ʻano o nā papa me ke kaʻi ʻana o 875 mg / 125 mg he 401-436 mau rubles (14 i kēlā me kēia pūpū), kahi pākēnē o 500 mg / 125 mg he 330-399 rubles (15 no kēlā ʻupena), 250 mg / 125 mg - 170‒241 mau rubles (ʻo ka pālahaluna he 15 mau pcs.). ʻO ka pauka no ka hoʻomākaukau ʻana no ke kāpena ʻana i ka hoʻopuka waha ma kahi o 400 mg / 57 mg hiki ke kūʻai ʻia no nā 158–273 mau rubles, kahi hapaha o 250 mg / 62.5 mg no 212-299 rubles, kahi dosage o 125 mg / 31.25 mg - 99-1123 mau rubles. . ^ E Ha yM. ʻO ka Powder no ka hoʻomākaukau ʻana o ka maʻi i ka inake me kahi kaʻe o 1000 mg / 200 mg ke kumukūʻai e pili ana i ka 675-862 rubles, me kahi kaona o 500 mg / 100 mg - 465-490 rubles (ʻo kēlā me kēia pūpū he 5 mau pōkole).

Nā hiʻohiʻona o ka lāʻau

ʻO ka papa inoa piha piha o ka Amoxiclav e loaʻa ai nā lāʻau lapaʻau e pili ana i ka amoxicillin a me ka clavulanic acid, no ka laʻana, Augmentin, Flemoklav Solutab. ʻAʻole lawa kahi mākaukau no ka hoʻomākaukauxika ʻo ka microxicillin no ka mea ʻoi aku ka liʻiliʻi o ka papa o nā microorganism i ka amoxicillin maʻemaʻe loa ma mua o kēlā me Amoxiclav. Hiki i nā mea like ke pili i nā lāʻau lapaʻau hou o ka hui penicillin - ʻaʻole paha i hui pū ʻia ke ʻano o ke kāʻei ʻana me ka wō o ke noi a Amoxiclav.

Pākuʻi helu

Nā papa hana ʻulaʻī

Nā mea waiwai (kiko): kēlā me kēia papa 250mg + 125mg ka 250 mg o ka amoxicillin ma ke ʻano o ka trihydrate a me 125 mg o ka clavulanic acid ma ke ʻano o ka paʻakai pālala,
kēlā me kēlā me kēia 500 mg + 125 mg pākāneka e loaʻa ka 500 mg o ka amoxicillin i ke ʻano o ka trihydrate a me 125 mg o ka clavulanic acid ma ke ʻano o ka paʻakai pākawa,
kēlā me kēia 875 mg + 125 mg ka papaʻu he 875 mg o ka amoxicillin ma ke ʻano o ka trihydrate a me 125 mg o ka clavulanic acid ma ke ʻano o ka paʻakai paʻakai.
Nā mea hoihoi (no kēlā me kēia pākahi): ʻO ka silicaidal silikon colloidal 5.40 mg / 9.00 mg / 12.00 mg, crospovidone 27.40 mg / 45.00 mg / 61.00 mg, sodium croscarmellose 27.40 mg / 35.00 mg / 47.00, hiki ke hoʻopaʻa ʻia ka pākuʻi 12.00 mg / 20.00 mg / 17.22 mg, talc 13.40 mg (no ka dosage 250 mg + 125 mg), cellulose microcrystalline a hiki i ka 650 mg / a i ka 1060 mg / a i ka 1435 mg,
papa kiʻi kiʻi 250mg + 125mg - hypromellose 14.378 mg, ethyl cellulose 0.702 mg, polysorbate 80 - 0.780 mg, triethyl citrate 0.793 mg, titanium dioxide 7.605 mg, talc 1.742 mg,
Nā ʻāpana kukui kiʻi 500mg + 125mg - hypromellose 17.696 mg, ethyl cellulose 0.864 mg, polysorbate 80 - 0.960 mg, triethyl citrate 0.976 mg, titanium dioxide 9.360 mg, talc 2.144 mg,
nā papa hana kiʻi ʻoniʻoni 875mg + 125mg - hypromellose 23.226 mg, ethyl cellulose 1.134 mg, polysorbate 80 - 1.260 mg, triethyl citrate 1.280 mg, titanium dioxide 12.286 mg, talc 2.814 mg.

ʻO keʻano

250 mg + 125 mg papa: keokeo a i ʻole paha keʻokeʻo, ʻokeʻo, octagonal, biconvex, nā ʻoniʻoni kāwili ʻia me nā paʻi 250/125 ma kekahi ʻaoʻao a me AMC ma ka ʻaoʻao.
Nā papa 500 mg + 125 mg: keʻokeʻo a ʻokoʻa paha ke keʻokeʻo, ʻaukā, nā papa biconvex, kāwele i ka ʻoniʻoni.
875 mg + 125 mg papa: keokeo a i ʻole paha ke keʻokeʻo, ʻokeʻo, biconvex, nā pani ʻia i hana ʻia me nā kiʻi ʻoniʻoni a me kahi manaʻo o "875/125" ma kekahi ʻaoʻao a me "AMC" ma kekahi ʻaoʻao.
Ka nānā ʻana i kahi kink: kaomi melemele.

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau
Nā hana hana i ka hana
ʻO Amoxicillin kahi penicillin semi-synthetic e hoʻohana ana i nā microorganisms gram-maikaʻi a me ka gram-negatif. Hoʻopiliʻo Amoxicillin i ka biosynthesis o peptidoglycan, ʻo ia kahi hiʻohiʻona hiʻohiʻona o ka pā o nā paia o nā maʻi bacterial. ʻO ka hoʻonāukiuki o ka synthesis o ka peptidoglycan e alakaʻi i ka nalowale o ka ikaika o ka pā o ke kelepona, e alakaʻi ana i ka lysis a me ka make o nā mea microorganism. I ka manawa like, hiki i ka amoxicillin ke hōʻemi nei i ka luku, e nā beta-lactamases, a no laila ke kahe mai o ka hana o ka amoxicillin e hoʻopili i nā microorganism e hana nei i kēia enzyme.
ʻO Clavulanic acid, kahi beta-lactamase inhibitor struktally pili i penicillins, hiki i ka hana ke hana i ka nui o nā beta-lactamases i loaʻa i ka penicillin a me nā microorganism kūloko cephalosporin pale. Loaʻa i ka waikawa Clavulanic e kūpaʻa ana i ka plasmid beta-lactamases, ka mea e hoʻonele pinepine ai i ka pale ʻana i ka maʻi bacterial, ʻaʻole ia he hopena me ka type chromosome beta-lactamases, ka mea i pale ʻole ʻia e ka clavulanic acid.
ʻO ka heleʻana o ka acid clavulanic i ka mākaukau e mālama ana i ka amoxicillin mai ka luku ʻana e nā enzymes - beta-lactamases, kahi e hiki ai ke hoʻonui i ka lolo o ka antibacterial o amoxicillin.
ʻO ka mea aʻe ka hana hoʻohui vitro o ka amoxicillin me ka waila clavulanic.

Lapaʻau lāʻau
ʻO nā hiʻohiʻona nui o ka pharmacokinetic o ka amoxicillin a me ka acid clavulanic i like. Hoʻopū maikaʻi ʻo Amoxicillin a me clavulanic acid i loko o nā hopena wai me ka pH physiological a, ma hope o ka lawe ʻana iā Amoxiclav ® i loko, ua piha koke i ka piha o ka gastrointestinal tract (GIT). ʻO ke komo ʻana o nā mea hana a ka amoxicillin a me ka waikawa clavulanic e ola maikaʻi inā e lawe ʻia ma ka hoʻomaka ʻana o kahi pāʻina.
ʻO ka bioavailability o amoxicillin a me clavulanic acid ma hope o ke alakaʻi waha ma kahi o 70%.
Hāʻawi ʻia nā mau lāʻau pharmacokinetic o amoxicillin a me ka acid clavulanic ma lalo iho o ke alakaʻi ʻana ma ka hāhā o 875 mg / 125 mg a me 500 mg / 125 mg pākahi i kēlā lā i kēia lā, 250 mg / 125 mg ʻekolu mau manawa i ka lā ma o nā mea kōkua olakino.

Kahele
Hāʻawi ʻia nā ʻano ʻelua i ka maikaʻi o ka hoʻoili ʻana i nā ʻāpana like ʻole, nā ʻāpana a me nā wai o ke kino (ma ka pūpū, nā ʻōpū o kaʻili, nā adipose, nā iwi a me nā ʻōpū, nā pelu, nā synovial a me nā peritoneal, ma ka ʻili, bile, urine, urine, pus ka hoʻoluke, sputum, i loko o ka'āpana interstitial).
ʻO ka pilina o ka protein Pluring he maʻalahi: 25% no ka clavulanic acid a me 18% no ka amoxicillin.
ʻO ka nui o nā hoʻoili e pili ana i ka 0.3-0.4 L / kg no ka amoxicillin a ma kahi o 0.2 L / kg no ka clavulanic acid.
ʻAʻohe amoxicillin a me clavulanic acid e pani i ke kahe koko-lolo i ka meninges uninflamed.
ʻO Amoxicillin (e like me ka hapa nui o ka penicillins) a hoʻopiʻi ʻia i ka waiū umauma. Loaʻa ka loaʻa o nā punawai clavulanic i nā umauma umauma. ʻO Amoxicillin a me clavulanic acid e hoʻōla i ka paepae placental.
Hāpai
Ma kahi o 10-25% o ka hoʻomaka mua o ka amoxicillin e hoʻopiʻi ʻia e nā keiki ma ka ʻano o ka waikawa penicilloic inactive. ʻO ka mole Clavulanic i loko o ke kino o ke kanaka ke hoʻomālamalama i ka hana kūlohelohe me ka hoʻokumu ʻana o 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid a me 1-amino-4-hydroxy-butan-2-one a hoʻāliʻi ʻia e nā ʻōpū, ma o ke kaomi ʻana, a me ka ea me ka ea ʻana, ma ke ʻano o ke kahe o nā ʻona.
Leʻaleʻa
Hoʻokomo ʻia ka Amoxicillin e nā keiki, aʻo ka clavulanic acid ma o ka pūnāwai a me nā hana extrarenal. Ma hope o ka lawelawe waha hoʻokahi o ka papa hoʻokahi, 250 mg / 125 mg a i 500 mg / 125 mg, aneane 60-70% o amoxicillin a me 40-65% o ka clavulanic acid e pau i ka loli ʻole e nā keiki ma ka 6 mau hola mua.
ʻO ka haʻahaʻa hapalua hapalua (ola (T1 / 2) o ka amoxicillin / clavulanic acid ma kahi o hoʻokahi hola; ʻo ka ʻokoʻa holoʻokoʻa huakaʻi ma kahi o 25 l / h i nā maʻi maʻi.
ʻO ka nui o ka waikawa clavulanic i hoʻopili ʻia i ka wā 2 mau hola ma hope o ka hoʻokele ʻana.
ʻO ka maʻi me ka hana renal impaired
ʻO ka huina piha o ka amoxicillin / clavulanic acid e hōʻemi ana i ka hoʻokaʻawale ʻana i nā hana o ka renal. ʻOi aku ka hoʻopiʻi ʻia ʻana i nā mea hou aku no ka amoxicillin ma mua o ka clavulanic acid, no ka mea ʻO ka hapa nui o nā amoxicillin i hoʻopā ʻia e nā keiki. Pono e koho ʻia nā ʻōpala o ka lāʻau no ka hiki ʻana i ka renal i ka manaʻo pono ʻole o ka hoʻopiʻi ʻana o ka amoxicillin i ka wā e mālama ana i kahi pae maʻamau o ka clavulanic acid.
ʻO nā mea maʻi me ka hana pūlima hemahema
I nā mea maʻi me ka pīhoihoi hana ʻino, hoʻohana ʻia ka lāʻau lapaʻau me ka mālama aka, pono e kiaʻi mau i ka hana o ka ate.
Hoʻokuʻu ʻia nā ʻaoʻao ʻelua i ka hemodialysis a me nā liʻiliʻi liʻiliʻi e nā dialysis peritoneal.

Hoʻohana i ka wā hāpai a i ka wā o ka umauma

ʻAʻole i hōʻike ʻia nā haʻawina holoholona i nā mea pili i nā pōʻino o ka lawe ʻana i ka lāʻau lapaʻau i ka wā o ka wā hāpai a me kona hopena i ka hoʻolālā ʻana o ka wahine hānau.
ʻO kekahi noiʻi i loko o nā wahine me ka wā wehe mua o ka membranes amniotic i loaʻa ka prophylactic hoʻohana o ka amoxicillin / clavulanic acid i hoʻopili ʻia me ka nui o ka loaʻa o ka enterrotitis necrotizing i nā keiki hou.
I ka wā hāpai a me ka lactation, hoʻohana ʻia ka lāʻau lapaʻau inā wale nō ka pōmaikaʻi i makemake ʻia i ka makuahine ma mua o ka nui o ka pilikia i ka maʻi ʻo ke keiki a me ke keiki.
ʻO Amoxicillin a me clavulanic acid i kahi liʻiliʻi liʻiliʻi e komo i loko o ka waiū umauma.
I nā pēpē e loaʻa ana i ka umauma, ka hiki ke hoʻomohala ʻana i ka naʻau, ʻeha, kandidiasis o nā membrane mucous no ka waha waha. Ke lawe ʻana iā Amoxiclav ®, pono ia e hoʻoholo i ka hoʻopau ʻana o ka umauma.

Loaʻa ka hopena

Wahi a ka World Health Organization (WHO), ua ʻokaʻawale ʻia nā hopena makemake e like me ka nui o ka neʻe ʻana e like me kēia: pinepine loa (≥1 / 10), pinepine pinepine (≥1 / 100, mai ka gastrointestinal tract)
pinepine pinepine: nā ninia
pinepine: hemo wale, he luaa. ʻIke pinepine ʻia ke kaila ke hele ʻana i nā papa kiʻekiʻe.
Inā hōʻoia ʻia nā hōʻino o ka gastrointestinal tract, hiki ke hoʻopau ʻia lākou inā lawe ʻoe i ka lāʻau i ka hoʻomaka ʻana o ka pāʻina.
nuliuliu: hoʻoweliweli ka hoʻonāukiuki
loa loa: colitis e pili ana i ka maʻi (me ka colitis hemorrhagic a me ka colitis pseudomembranous), ʻeleʻele "lauoho" ʻiliʻili, gastritis, stomatitis.
Ma ka ʻāpana o ka ate a me ka pāpaʻi biliary
nuliuliu: ka hana o ka alanine aminotransferase (ALT) a me / a aspartate aminotransferase (AST). Hōʻike ʻia kēia mau mea i loko o nā mea maʻi e loaʻa ana i ka hoʻomehana maʻi o ka beta-lactam, akā ʻaʻole ʻike kona ʻike.
loa loa: jaundice cholestatic, hepatitis, hoʻonui hana o ka alkatine phosphatase, hoʻonui i ka hana o bilirubin i loko o ke koko koko.
ʻO nā hopena ʻino loa mai ka ate ka mea i nānā nui ʻia i nā kāne a me nā poʻe maʻi maʻi a pili paha me ka ʻōlelo lōʻihi. Hōʻike pinepine ʻia kēia mau ʻano maikaʻi ʻole i nā keiki.
ʻO nā hōʻailona a me nā hōʻailona i hele pinepine ʻia ma ke a ma hope iho o ka pau ʻana o ka hoʻōla, eia naʻe i kekahi mau hihia ʻaʻole paha e ʻike ʻia no kekahi mau hebedoma ma hope o ka pau ʻana o ka maʻi. ʻO ka hopena ʻino ke hoʻololi pinepine ʻia.
Hiki i ka hopena hōʻeha ke hoʻopili i ka leʻa, ma nā hihia koʻikoʻi loa i hōʻike ʻia nā hopena o nā hopena hōʻeha. I ka hapa pinepine, ʻo kēia mau mea me ka pathology concomitant koʻikoʻi a i ʻole kekahi e loaʻa i nā lāʻau hepatotoxic i ka manawa like.
Mai ka pā kūlohelohe
loa loa: angioedema, anaphylactic reaksi, allergic vasculitis,
Ma ka ʻāpana o ke koko a me ka ʻōnaehana lymphatic
jarang: leukopenia hōʻano hou (me ka neutropenia), thrombocytopenia,
loa loa: hiki ke hoʻololi ʻia agranulocytosis, hemolytic anemia, hoʻihoʻi hou ʻana i ka manawa prothrombin, hiki ke hoʻonui i ka manawa koko (ʻike i ka ʻāpana "Kūlana Kūlana"), eosinophilia, thrombocytosis.
Mai ka pūnaehana pili ʻana
nuliuliu: ʻeha, poʻomana,
loa loa: hiki ke hōʻino ʻia (hiki i nā mea maʻi me ka hana ʻole o ka ukali, a i ka wā a ke kau ʻana i ka nui o ka lāʻau lapaʻau), hoʻohālikelike ʻia ka maʻi, ka meningitis aseptic, nā manaʻo o ka hopohopo, ke ʻole, ke hoʻololi ʻana i ka hoʻāla.
Ma ka ʻāpana o ka ʻili a me ke kiko
nuliuliu: nā ʻili ʻili, pruritus, urticaria,
jarang: erythema multiforme exudative,
loa loa: dermatitis exfoliative, ʻ syndromelelo Stevens-Johnson, ka pustulosis exanthematous ākea, kahi maʻi maʻi e like me ka maʻi serum, toxac epidermal necrolysis.
Mai ka pūpū a me ka ʻihi
loa loa: interstitial nephritis, crystalluria (ʻike i ka ʻāpana "Overdose"), hematuria.
Nā maʻi maʻi a me nā maʻi parasit
pinepine: kandidiasis o ka ʻili a me nā membrane mucous.
ʻO kekahi
ʻaʻole maopopo: ka ulu ʻana o nā microorganisms insensitive.

Mea hana

Luna iā RU: Lek dd, Verovshkova 57, 1526 Ljubljana, Slovenia,
Hana ʻia ia: Lek dd, Perzonali 47, 2391 Prevale, Slovenia.
Pono e hoʻouna ʻia nā koi o nā mea kūʻai aku iā ZAO Sandoz:
125315, Moscow, Leningradsky Prospekt, 72, bldg. 3.