Nā papa Emoxipin: nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana

ʻO Emoxipine (INN - Emoxipine) kahi angioprotector e hōʻemi ana i ka pae o ka hoʻokele o nā pā vascular ma muli o ka wikiwiki o nā hana radical manuahi, ʻo ia hoʻi ka lāʻau lapaʻau ka antioxidant a antihypoxant. ^ E Ha yM. E hōʻemi ʻo Emoxipin i ka nānā maka koko, nā mana ākea o ka vascular, a me ka ulu ʻana e hoʻomōhala i nā hemorrhages. Eia kekahi, ʻo nā mea hana o ka lāʻau lapaʻau e hoʻonui i ka pae o nīliko nucleotides i ka lolo a me nā pelela koko.

Hōʻike ʻia ka hana Fibrinolytic o ka lāʻau lapaʻau me ka mea nui e pili ana i ka wā o kahi manawa puʻuwai puʻuwai, hiki i ka ʻenehana ke hoʻonui i nā moku coronary, no laila e kaupalena ana i ka hoʻomaka nā ʻōpū. ^ E Ha yM. Eia nō hoʻi, e hoʻomaikaʻi ka mea kūpono a me ka mea paʻa.

ʻO kahi mea ophthalmic, he mau retinoprotective ka mea o ka emoxipin, pale ia i ka retina mai ka hana o nā kukui māmā. E kōkua nā papa o Emoksipin i ka hoʻoholo ʻana hemorrhage i loko a hoʻomaikaʻi i ka ʻōnaehana microcirculation ma ka maka.

Pharmacodynamics a me ka pharmacokinetics

Lapaʻau lāʻau

ʻO ka hopena maikaʻi ake ʻaʻe koko: e ka hoʻohaʻahaʻa ʻana i ka index coagulation ākea a me ka hoʻēmi ʻana i ka platelet aggregation, hoʻonui ka lāʻau lapaʻau i ka manawa coagulation koko. ʻO nā membrane o nā puna a me nā kīʻaha koko ma lalo o ka hana o ka lāʻau ke hoʻomau nei, ʻāwili koko ʻōwili hoonui i ko lakou pale ana i hemolisis a me kekahi pōʻino hoʻi.

E mālama pono ana i ka hoʻihoʻi manuahi-free radical lipid i loko o nā biomembranes. Hoʻonui ka hana o nā enzymes e pili ana i ka hana antioxidant. Hiki i ka hāʻawi ʻO ka hopena lipid-haʻahaʻa ma ka hoʻemi ʻana i ka hoʻohuihui ʻana o ka triglycerides.

Hiki i ka manaʻo o Emoksipin ke hōʻemi i nā hōʻikeʻike hemods serebral. ^ E Ha yM. He hopena maikaʻi kona i ka hoʻomau ʻana o ka cortex cerebral i ischemia a hypoxia. ^ E Ha yM. Nā hoʻoponopono kahi hana autonomic i nā hihia o ka maʻi cerebrovascular.

ʻO Emoxipin kahi hopena cardioprotective i loaʻa. E pale ʻia ka ʻōnaehana cardiovascular inā inā he pōʻino ischemic isocicial: Hoʻokaʻa ka lāʻau i kona hoʻoiho, ke hoʻonui ʻana i nā moku coronary.

I a makaka ka maka Mālama ʻo Emoxipin i ka retina i ka hiki ke hōʻino ʻia ma o ka ʻike ʻana i nā kukui māmā. Eia kekahi, ma muli o ka lāʻau, hiki i ka resorption o ka hemorrhages i loko o ka maka.

Lapaʻau lāʻau

Ma ka hihia o kahi dosis intravenous o 10 mg no 1 kg o ka mea hoʻomanawanui, ʻike ʻia kahi helu haʻahaʻa loa hapalua o ka hoʻopau ʻana i ka lāʻau. ^ E Ha yM. ʻO ka hoʻopau ʻana o ka maʻamau he 0,041 min, ʻo ka ʻike ākea o ka hoʻoili ʻana he 5.2 l, ʻo ka huina o ka hoʻomaʻemaʻe ʻana he 214.8 ml i hoʻokahi minuke.

Hoʻopokolo koke ka lāʻau lapaʻau i nā ʻāpana a me nā ʻili o ke kino o ke kanaka a ʻo ia ka mea i hana ʻia hoʻokūkū.

Hiki i nā pharmacokinetics o Emoxipin ke ʻano like me ke kūlana o ka mea maʻi. ʻO ka laʻana, ma ka hihia o kahi kūlana pathological ke komo ʻana i ke coronary, e ho'ēmi ka wikiwiki i ka mea i hoʻopau ʻia i ka lāʻau, no laila e lilo i ka bioavailable.

Ma ke ʻano o ka hoʻomālamalama retrobulbar o Emoxipine, ʻike koke ʻia nā mea kanu o ka lāʻau lapaʻau i loko o ke koko, ke ʻano kiʻekiʻe o ka pae ʻana i ʻelua mau hola, a ma hope o 24 mau hola ma hope o ke keʻena ʻana, ua aneane pau loa ke ʻōpala o ka lawelawe i loko o ke koko. Hoʻokomo ʻia kekahi paʻa o ka lāʻau i loko o nā ʻili o ka maka.

Nā hōʻailona no ka hoʻohana ʻana o Emoxipin

I a makaka ka maka nā hōʻike hōʻike no ka hoʻohana ʻana:

hemorrhage i loko,
ʻōpalaola ma ke kikowaena o ka retina o ka maka a me kona mau lālā.
glaucoma,
ʻO ka pale o ke kumu coagulation laser a me ke kukui nui (ma ka hoʻopili o ka lā a me ka wela o ka ʻenehana laser).

Nā hōʻailona no ka hoʻohana ʻana Nā ʻōlelo waiʻo Emoxipin:

Eia kekahi, hoʻohana nā inikini Emoxipin i ka hihia a me ke oʻeha nā neʻe o ka loloinā he kumu hemorrhagic a me nā maʻi ischemic ka hopena. Inā kūpono, hiki ke lawelawe ʻia ka lāʻau lapaʻau ma ke ʻano he intramuscular injection, a i ʻole he maʻi intravenous i loko o nā ampoules.

Nā hopena hopena

Hiki i nā hopena ʻino aūlūkahi ma hope o kahi manawa pōkole e lilo hiamoe. ^ E Ha yM. Loaʻa hoʻonui i ke koko a hele mai ʻohiʻala. ^ E Ha yM. Hiki i nā kūloko o ke kūloko ke hōʻike iā ia me ka hōʻeha, ka ʻeha, ka hoʻā ʻana o ke ahi, ʻulaʻula a me ka paʻa o nā pā paraorbital.

Nā ʻōkuhi no ka hoʻohana ʻana iā Emoxipin (Ke ʻano a me ka helu ana)

Nā kauoha no Emoxipin - hāʻule nā maka

I ka hoʻokō o ka hoʻomālamalama o retrobulbar o ka lāʻau lapaʻau, hoʻokahi hopena pākēneka i loko o kahi waihona o 0.5 ml e lawelawe ʻia 1 ka manawa no ka lā no 10-15. Inā mālama ʻia ka lāʻau lapaʻau subconjunctival a parabulbar, a laila mai 0.2 a 0.5 ml o ka lāʻau lapaʻau ke mālama ʻia i hoʻokahi manawa i ka lā no 10-30 mau lā.

Inā pono e pale i ka retina ocular, mālama ʻia ka lāʻau i ka retrobulbarly ma loko o kahi he 0.5 ml no kēlā me kēia lā a hoʻokahi hola ma mua o ka coagulation laser. Aia ke ʻano i ka papa o nā kauka i loaʻa ma ka coagulation laser, i ka nui o nā hihia, ua kau ʻia nā kulu i ka retrobulbarly hoʻokahi manawa i ka lā mai nā lā ʻelua a ʻumi paha.

Nā kauoha no Emoxipin - injection

Ma ka cardiology a me ka neurology, hoʻohana nui ʻia ka lāʻau intravenously me kahi dropper i ka nui o 20-40 mau minuke i kēlā me kēia minuke. ʻO ka makeʻana o ka lāʻau lapaʻau he 20-30 ml o kahi kūleʻa ʻekolu ʻekolu. Hiki ke hāʻawi i nā pipi a i hoʻokahi a i ʻekolu mau manawa i ka lā no 5-15 mau lā. Aia i ka lōʻihi o ka mālama ʻana i ke ʻano o ka maʻi o ka mea maʻi. I ka pauʻana o nā pahu kipa, ua huli lākou i nā inikini intramuscular o ka lāʻau lapaʻau: 3-5 ml o kahi hoʻonā he 3% i hoʻopaʻa ʻia i 2-3 mau lā i ka lā. ʻO ke papa o ka intramuscular injection mai 10 a 30 mau lā.

ʻAʻole i hoʻokuʻu ʻia ka Emoxipin papa hana, no ka mea hiki ʻole iā ʻoe ke lawe i nā papa Emoxipin, no ka mea ʻaʻole wale nō.

Ke keu

Ma kahi o kahi overdose o ka lāʻau lapaʻau, hiki i ka hiʻohiʻona a hoʻonui paha i nā hopena hopena. Me kahi overdose o kahi lāʻau lapaʻau a i nā analogue paha, hoʻonui paha ia he pili kokopāwaho nui a i ʻole hiamoe, ʻeha i ka puʻuwai, hōʻeha, nininiʻeha paʻakikī ʻeha. Hiki ke kīnā ʻia ke koko.

ʻO ka hoʻōla ʻana o ka overdose o Emoxipin a me nā mea hoʻohālike o Emoxipin ke hoʻokuʻu i ka lāʻau lapaʻau a hana i nā kaʻina hana lapaʻau hōʻailona, inā pono.

Hoʻohui

Ma ka hihia o ka noi a me α-tocopherol acetate, ʻoi paha kahi hōʻike ikaika o nā mea antioxidant o Emoxipin. Ma keʻano holoʻokoʻa, ʻaʻole i ʻōlelo ʻia ka lāʻau e hoʻohui pū me ka hoʻohana ʻana i nā lāʻau lapaʻau ʻē aʻe me ka ʻole i ʻae ʻia mai ke kauka i hele mai.

Lapaʻau lāʻau

Ke hoʻolako ʻia ma ka hapa o 10 mg / kg, ʻo ka hapa hapalua o Ti / g ka 18 mau minuke, ʻo ka huina o CI ka 0.2 l / min, a me ka ʻike nui o ka hoʻoili ʻana iā Vd he 5.2 l.

Hoʻomoʻa nui ka lāʻau i loko o nā ʻōpū a me nā kiko, kahi e waiho ai a hoʻoliʻoli ʻia. Loaʻa ʻelima mau metabolites o emoxipin, i hōʻike ʻia e nā huaʻalekale kolo a hoʻohui ʻia i nā huahana o kona hoʻololi. Hoʻopiliʻia nā emoxipin metabolites e nā keiki. Loaʻa nā helu nui o 2-ethyl-6-methyl-3-hydroxypyridine-phosphate i loko o ka puʻuwai.

I nā kūlana patological, no ka laʻana, me ka hihia o ka coronary occlusion, ua loli nā pharmacokinetics o ka emoxipin. Ua emi ka nui o ka excretion, ka manawa i hoʻolilo ʻia e emoxipin i ke kahe koko, hiki ma muli o kona hoʻi hou ʻana mai ka depot, me ka ischemic myocardium.

ʻO ka lā kau

Mau makahiki 3 mai ka lā i hoʻopuka ai.

ʻO ka Emoxipin kahi lāʻau lapaʻau ikaika hou loa. ʻO kona wale wale nō ka huhū kūloko ikaika a hoʻohana ʻia. Hōʻalo ka poʻe i nā maʻi ophthalmic koʻikoʻi i nā loiloi maikaʻi loa e pili ana iā Emoxipine, no ka mea pili maoli lākou i nā ʻōlelo a ke kauka a, ma muli o ka pilikia o ka pilikia, maopopo maoli ka pono o ka mālama ʻana. Inā hoʻohana ʻia ka lāʻau lapaʻau no ka mālama ʻana i nā maʻi ophthalmic liʻiliʻi, a laila ʻaʻole i kūpono loa ka loiloi e pili ana i nā puʻupuʻu: ʻo ka ʻoiaʻiʻo ʻaʻole ʻo ka poʻe a pau e mākaukau e hoʻonā i nā mea hoʻowahāwahā wāwahi ʻole ma hope o ka lawe ʻana i ka lāʻau.

Hōʻike nā kauka e pili ana i nā kauka makaka ka maka - maikaʻi loa. Ke hoʻomake nei ka lāʻau lapaʻau me kāna hana, ʻoiai ke kumu e hōʻeha ʻole ai i ka poʻe maʻi.

Nā Ilina ʻO Emoxipin hoʻohālikelike pono i nā hopena o nā hōʻeha a me nā puʻuwai naʻau i nā mea maʻi he nui a puni ka honua. Eia kekahi, ke lawe nei i ka lāʻau lapaʻau i kahi manawa pōkole e kōkua i ka hōʻemi i nā hōʻike like ʻole o nā pilikia neʻe. He kūpono ke ʻano o ia ʻike maikaʻi i ka hoʻohana ʻia ʻana ma nā loiloi maikaʻi, mai nā maʻi a me nā kauka.

Kumukūʻai Emoxipin, kahi e kūʻai

Hiki iā ʻoe ke kūʻai i ka Emoxipin ma Kiev me nā pilikia ʻole: hiki ke loaʻa i ka lāʻau lapaʻau a i nā ʻiliʻili paha i loko o nā hale kūʻai āpau. Pēlā wale nō ka kumukūʻai e loli iki ma luna o ka lāʻau lapaʻau, eia naʻe, aneane loa nā hiʻohiʻona maka ma Ukraine, a me nā lāʻau ʻē aʻe e ʻano like i ke kumukūʻai. ʻAʻole ia wale nō ma ka palena o ka lāʻau lapaʻau ma luna o ka lāʻau lapaʻau, akā ma ka wahi o kāna hana, i hoʻokuʻu nui ai, etc.

He kumukūʻai kumukūʻai pani nā maka emoxipin 1% ma kahi pahu he 5 ml e loli ana i ka mākeke ma kahi o 60 UAH. Afi o elima ampoules Na 1 ml no hookahi keneta o Emoksipin Helu 10 e pili ana ia e pili ana i ka 50 UAH i kahi lāʻau.