ʻO Jasonvia a me Janumet > He hoʻomaʻemaʻe a me ke pale aku

ʻO nā lāʻau lapaʻau papaʻi 2 ʻo Januvia a me Janumet: ʻike i nā mea āpau e pono ai. Ma lalo ʻoe e ʻike ai i nā ʻōkuhi no ka hoʻohana ʻia ʻana ma kahi ʻāpana i loaʻa. Hōʻalo i nā hōʻailona, contraindications, dosages, pehea e lawe ai a hiki i nā hopena ʻaoʻao. Ua ʻōlelo ʻia e pili ana i nā hana mālama pono e hiki ai iā ʻoe ke mālama i ke kōhi koko 3.9-5.5 mmol / l mau 24 mau lā i ka lā, e like me ka poʻe olakino. ʻO ke ʻōnaehana o Dr. Bernstein, kahi i noho me ka maʻi diabetes ma mua o 70 mau makahiki, hiki iā ʻoe ke 100% pale iā ʻoe iho mai nā hoʻopiʻi. No nā kikoʻī, e ʻike i kahi hoʻoponopono lapaʻau hana a i kēlā me kēia laʻana no ka maʻi diabetes type 2.

ʻO Hoavia kahi lāʻau lapaʻau no nā maʻi maʻi type 2, ʻo ia ka mea ikaika o ka sitagliptin. ʻO ka mea hana hana he mea kaulana kaulana ʻoihana ʻo Merck (Netherlands. ʻO Yanumet kahi lāʻau lapaʻau hoʻohui e loaʻa ai ka sitagliptin a me ka metformin. Ke hoʻohālikelike ʻia nei ma lalo nei nā kikoʻī o nā papa o Januvia a me Galvus, a me Yanumet a me Galvus Met. Hāʻawi ʻia kahi pane kūlike i ka nīnau no hea o kēia mau lāʻau i ʻoi aku ka maikaʻi. ʻO nā mea i hoʻohālikelike ʻia e nā mea hoʻohālike me ka ʻoihana kūʻai lapaʻau e helu ʻia.

ʻO Jasonvia a Janumet: ʻatikala kikoʻī

E heluhelu i nā mea e hana inā hiki ʻole iā Izvia a me Galvus i hiki iā ʻoe ke hoʻohana ʻole i kāu lāʻau lapaʻau i hoʻōki i ke kōkua ʻana. E aʻo pehea e mālama pono ai i ke kōpaʻa koko a mālama i nā kumukūʻai nui.

Nā ʻōkuhi no ka hoʻohana

Ka hana lāʻau lapaʻau

ʻO Sitagliptin kahi mea pale i ka pūnaehana DPP-4. Hoʻonui nā mea o nā kukuna o ka ʻohana resinlet. Hoʻonohonoho kēia mau mea i ka pancreas e hana i ka insulin i ka pane ʻana i ka ʻaina meaʻai, a hōʻemi pū kekahi i ka mea huna o ka glucagon. Ma muli o kēia, hōʻemi iki ke kō o ke koko me ka ʻole o ka loaʻa ʻana o ka hypoglycemia. Hoʻokuʻu ʻia ia e nā pōpoki me ka urine ma o 80-90%, ma ka pepeka - ma 10-20%. ʻO nā mea maʻi e lawe nei iā Janumet e pono e heluhelu ma aneʻi e pili ana i ka hopena o nā metformin.

Nā hōʻailona no ka hoʻohana ʻana

ʻAno maʻi type 2. ʻO ka meaʻai maikaʻi a me ka hana kūlohelohe ʻo ia ke kumu nui o ka mālama ʻana, a me nā ʻōpū a me nā insulin e kōkua. E nānā i ka ʻatikala "Diet for Type 2 Diabetes." ʻO ka lāʻau lapaʻau o Hoavia (sitagliptin) hiki ke hui pū me ka metformin. Loaʻa nā papa hoʻohui ʻo Yanumet i loaʻa nā sitagliptin a me ka metformin ma lalo o kahi pūpū.

Ke lawe nei iā Januvia, Janumet a i ʻole he mea hoʻohālike a me nā maʻi maʻi ʻē aʻe, pono ʻoe e ukali i kahi ʻaʻai.

Nā Hoʻohui

ʻAno maʻi type 1. ʻLelo ʻia a me ka wā o ka umauma. ʻO nā hoʻopiʻi huehue e hoʻopiʻi ʻia e ke koko koko nui, ʻo ka ketoacidosis, hyperglycemic coma. He 18 makahiki. Allergic reaksi aʻai ma ke ʻano o nā mea ikaika a me nā mea kōkua o ka lāʻau. Loaʻa nā metformin i nā contraindications ma mua o sitagliptin. E heluhelu hou aʻe e pili ana iā lākou ma aneʻi.

Nā ʻōlelo kikoʻī

ʻO ka lāʻau hoʻohui i hoʻopaʻa ʻia me ka maʻi maʻamau ʻo 2, ʻaʻole i kūkā ʻia me ka nui o Iovia me nā inikini insulin, me ka ʻaina sulfonylurea. ʻO ka mea mua, hele i kahi meaʻai haʻahaʻa-haʻahaʻa. Me nā waiwai gula o 9.0 mmol / L a kiʻekiʻe aʻe, e hoʻomaka koke i ka injecting i ka insulin, a laila hoʻokomo i nā papa. Heluhelu i ka ʻatikala "Type 2 diabetes insulin" no ka ʻike hou aku.

ʻĀnō

ʻO ka maʻi maʻamau o ka sitagliptin (Januvia) ka 100 mg i kēlā me kēia lā. Lawe i ka lāʻau lapaʻau 1 manawa i kēlā me kēia lā, me kahi mea ʻole o ka ʻaina. I ka hihia o ka hiki ʻole o ka renal modaging (clearanine clearance 30-50 ml / min, serum creatinine content 1.7-3 mg / dl i nā kāne, 1.5-2.5 mg / dl i nā wahine), hoʻoemi ʻia ka lāʻau i ka 50 mg i kēlā me kēia lā. Ma kahi hana hoʻopōkino nui, 25 mg i kēlā me kēia lā. Pono ka lā o Janumet i ʻelua mau manawa i ka lā. Hiki iā ʻoe ke lawe i hoʻokahi papa o ka metformin maʻemaʻe. E heluhelu hou e pili ana i ke koho ʻana o kāna 'ōlelo.

Nā hopena hopena

Ua hoʻomanawanui maikaʻi ʻia ka lāʻau lapaʻau o Hoavia, e hōʻemi i nā hopena ʻaoʻao i nā manawa pinepine ʻole ma kahi pletebo. I ka manawa i loaʻa, e hele mai nā maʻi o ka hanu kiʻekiʻe. Hoʻonui iki ka kiʻekiʻe o ka waikika uric i ke koko ma o 0.2 mg / dl. ʻAʻole pono kēia e hoʻonui i ka loli o ka gout. Inā ʻoe ke lawe nei iā Janumet, a laila e heluhelu ma ʻaneʻi e pili ana i nā hopena o nā metformin. ʻOi aku lākou ʻoi aku ka ulu a me ka maʻi nui ma mua o ka sitagliptin.

Hāpai a me nā pēpē	ʻAʻole kuhikuhi ʻia nā lāʻau lapaʻau Januvia a me Janumet e hoʻomalu i ke kō koko kiʻekiʻe i nā wahine i ka wā hāpai. ʻAʻole hoʻohana ʻia nā lāʻau maʻi maʻi. Inā pono, e hoʻokomo i ka insulin. E ho'āʻo e hana me ka ʻole o lākou, ma muli o ka meaʻaiʻai. Heluhelu i ka ʻatikala "Pabetis Diabetes" a me "Gestational Diabetes" no ka ʻike hou aku.
Hoʻopili me nā lāʻau lapaʻau ʻē aʻe	ʻAʻole like ka pilina o ka sitagliptin me nā lāʻau lapaʻau ʻē aʻe. Akā no ka metformin i ka hoʻohui o nā papa Janumet, aia kahi kūlana o kēia. E heluhelu e pili ana i kāna mau lāʻau lapaʻau ma aneʻi. E kamaʻilio me kāu kauka e pili ana i nā lāʻau lapaʻau, nā mea kanu meaʻai, a me nā mea kanu āu e lawe nei.
Ke keu	ʻO nā hihia o kahi hoʻokahi o nā haʻahaʻa o Januvia i nā dosis a hiki i ka 800 mg e wehewehe. ʻAʻohe mea maʻi iki nā maʻi maʻi, koe wale nō me kahi loli iki o ke kikowaena QT ma ka lolo. Hiki i ke overdose o metformin ke lilo i pilikia koʻikoʻi. Pono e hana i ka lavage gastric, mālama i ka maʻi hōʻailona a me ke kākoʻo kākoʻo. Kōkua ʻo Dialysis i ka hoʻoiho ʻana i ka sitagliptin mai ke kino.
E hoʻokuʻu i ke ʻano	Januvia - nā papa beige, mauʻu. Ma kekahi ʻaoʻao kahi biconvex, ua kahakaha ʻia "277". Ma ka ʻaoʻao ʻē aku e mama ai. Aia ʻo Yanumet i nā papa he 50 mg o ka sitagliptin a me nā koina o ka metformin - 500, 850 a me 1000 mg. No ka hoʻoholo ʻana i ke kūpono kūpono o ka metformin, e heluhelu i kēia ʻatikala.
Nā kuleana a me nā kūlana e waiho ai	E hoʻomau i ka hiki ʻana o nā keiki i nā mahana ʻaʻole iʻoi aku ma mua o 30 ° C. ʻO 2 mau makahiki kahi ola.
Hōʻike	ʻO ka mea kūpono ka sitagliptin i ke ʻano o ka hoʻohālikelike phosphate. ʻO nā mea kōkua - microcrystalline cellulose, calcium hydrogen fosfate, sodium croscarmellose, magnesium stearate, sodium stearyl fumarate. Nā papa pāpaʻi - Opadry II beige 85 F17438, ka waiū polyvinyl, ka titanium dioxide, macrogol (polyethylene glycol) 3350, talc, ka hao oxide ka melemele a me ka ulaula.

ʻAʻohe o nā huahelu haʻahaʻa o ka lāʻau o ka lāʻauvia no ka mea no ka mea, ʻaʻole i pau ka pono o ka paena no ka sitagliptin. Inā hiki ʻole ʻoe i kēia lāʻau lapaʻau, huli i ka metformin maʻemaʻe - maikaʻi loa ʻo Glucofage a Siofor paha. Me ka hoʻololi i kaʻai haʻahaʻa-haʻahaʻa, ʻoi aku ka nui o nā meaʻai. Akā, he mea nui loa nā meaʻai o ka protein. He mea kūpono lākou ma mua o nā hoʻolimalima. A hiki iā ʻoe ke ho'ōla i nā paila maʻi maʻamau.

ʻO nā lāʻau lapaʻau e like me Januvius ʻo Galvus (vildagliptin), Ongliza (saxagliptin), Trazenta (linagliptin), Vipidia (alogliptin) a me Satereks (gozogliptin). Hoʻohana ʻia lākou e nā mea hoʻokūkū lāʻau.

Mālama ʻia kēia mau lāʻau āpau e nā patent. ʻIke aku, ʻae like nā mea hana i waena o lākou e mālama i nā kumukūʻai kiʻekiʻe. ʻO nā mea ikaika i kapa ʻia nā glyptins. Hāʻawi liʻiliʻi lākou i ke kō koko. ʻAʻole pono ke hoʻonui ʻē iā lākou. I nā kumukūʻai e pili ana i ka metformin maʻemaʻe ke kumu kūʻai a kōkua ke like pū kekahi.

Pehea e lawe ai i kēia lāʻau lapaʻau?

Pono ka lāʻau o Nauvia i lawe ʻia i ka manawa 1 i kēlā me kēia lā ma kahi kikoʻī i kuhikuhi ʻia e ke kauka. Hiki iā ʻoe ke inu ma mua o a ma hope o kahi ʻai ʻana, e like me kou makemake. ʻO Yanumet e lawe maʻamau i 2 mau manawa i ka lā me ka meaʻai e hōʻoluʻolu i nā hopena ʻaoʻao o ka metformin. Ma ke kānāwai, he mea kūpono loa ke lawe i kahi paila o ka metformin maʻemaʻe i ka wā o ke kolu o ka pāʻina e hōʻea aku i ka nui o kēlā me kēia lā o kēia lāʻau lapaʻau 2550-3000 mg. A i ʻole e lawe iā Metformin Long-act Glucofage Long i ka pō e loaʻa ke kiʻekiʻe o ke kō koko koko maikaʻi ma ke kakahiaka. Mai poina e hoʻomaopopo i ke koho ʻana o ka pauku a me nā regimens dosage o metformin. Ua wehewehe ʻia lākou ma nā kikoʻī ma aneʻi.

ʻO Januvia a i Galvus: ʻoi aku ka maikaʻi?

ʻO nā hua lāʻau ʻOviavia (sitagliptin) a me Galvus (vildagliptin) i like like. Ua hoʻokūkū lākou me kēlā me kēia no nā puʻuwai a me nā pale o nā mea maʻi like like me 2. Paipai nui nā mea hana i kēia mau peni ma waena o nā kauka a me nā mea maʻi me ka maʻi maʻi. He nui nā mea hou aku i kākau ʻia ma luna. Eia nō naʻe, ma nā ʻāina e ʻōlelo nei a Rūsia ʻaʻole lākou i kaulana loa.

I kēia manawa, ʻaʻole lawa ka ʻikepili nui e pane ai i ka nīnau o ke lāʻau lapaʻau ka maikaʻi - Januvius a i Galvus paha. Eia nō naʻe, ʻoi aku ka mea e ʻoi aku ka maikaʻi ke lawe i nā papa hoʻohui i ʻike ʻia i kahi sitagliptin a i ʻole vildagliptin a hiki i ka metformin. E kamaʻilio me kāu kauka e pili ana paha ʻoe e hoʻololi iā Yanumet a i ʻole Galvus Met.

ʻO ka Metformin ka uku a me ka haʻahaʻa o ke kō o ke koko ma mua o ka sitagliptin a me vildagliptin. E hoʻolohe i ka lāʻau lapaʻau Galvus Met. Loaʻa iā ia nā loiloi hopena mai nā maʻi maʻi ma mua o nā lāʻau lapaʻau like like. ʻOi aku ka maikaʻi o nā metformin ma mua o nā gliptins. Eia naʻe, ma ke ʻano he kānāwai, ʻaʻole lākou e pilikia. Pono lākou e hoʻomanawanui no ka loaʻa ʻana o kahi hopena - hoʻomaikaʻi i ke kō koko a me ka hemoglobin glycated.

Pehea e pani ai iā Janumet?

Loaʻa ka poʻe maʻi i ka koho o Janumet me kekahi lāʻau lapaʻau hou i kēia mau kūlana:

ʻAʻole kōkua nā lāʻau i nā pale, ʻaʻole e hōʻemi i ke kōpaʻa koko.
ʻO nā hopena ʻaoʻao ka hopena koʻikoʻi, hikiʻole ke hoʻomālamalama.
E kōkua ana ka lāʻau lapaʻau, hiki i nā hopena ʻaoʻao, akā nui ke kumukūʻai.

Inā ʻaʻole kōkua ʻo Yanumet, ʻaʻole e hōʻemi i ke kō koko, a laila pono e hoʻololi i nā inikini insulin. ʻAʻole e hoʻāʻo ʻia nā papa ʻē aʻe. Ua emi paha ka pancreas a ka mea maʻi, a ua hoʻohuli ʻia ka maʻi diabetes type 2 hou i ke ʻano maʻi type 1. E aʻo i ka ʻatikala "Type 2 Diabetes Insulin" a hana i kāna mea e ʻōlelo ai. E hoʻomanaʻo ʻo kahi kīʻaha haʻahaʻa-mau ka maʻi e lilo i ka hoʻomaʻamaʻa nui, ʻaʻole ʻoe e nānā i ka insulin a i ʻole.

Loaʻa i ka hopena maikaʻi ʻole o ka lāʻau ʻo Janumet i ka metformin ma ke ʻano o kēia lāʻau. Ua heluhelu ʻoe ma luna aʻe he mea nui ka sitagliptin hoʻomake kumu nui no ka mea maʻi. ʻAʻole ʻoi loa aku ka liʻiliʻi ma mua o ka pletebo. Me nā hiʻohiʻona o ka metformin, pono ʻoe e hoʻololi iā lākou, hoʻomanawanui, ʻaʻole hoʻi e nānā i kahi mea kuʻi. No ka mea he lāʻau lapaʻau ʻona ka metformin no ka pono a me ka palekana. Hiki iā ia ke hōʻeha a me nā pilikia ʻē aʻe, akā ʻo kēia lāʻau lapaʻau ka hōʻemi i ke kō koko me ka ʻole o ka luku ʻana i ke kino. ʻO ke ʻano, ʻoi aku ka maʻalahi. No ka hōʻoluʻolu i nā hopena ʻaoʻao, e lawe iā Janumet a me ka metformin maʻemaʻe i ka meaʻai, ʻaʻole ma mua a ma hope o ka ʻai ʻana. E aʻo i ka pauna dosage ma aneʻi me ka piʻi nui o ka nui.

E mālama i ke kālā, hiki iā ʻoe ke hoʻololi mai ka lāʻau ʻo Arizonavia a i Yanumet hoʻi i ka metformin maʻemaʻe - nā mea maikaʻi loa o Glucofage a i ʻole Siofor, a ʻaʻole nā papa o ka hoʻopili home. Ua hoʻemi nui ʻia nā kumukūʻai o ka lāʻau lapaʻau, a e hoʻomau like a mālama ka maʻi diabetes. ʻOi loa inā ʻimi ʻoe i kahi meaʻai haʻahaʻa-haʻahaʻa haʻahaʻa, ʻaʻole hoʻi e palau mau i ka hoʻomaʻamaʻa.

He aha ka mea hypoglycemic agent?

Hoʻokomo ʻia ka lāʻau Yanumet i ka hui o nā lāʻau lapaʻau me ka hopena hypoglycemic. ʻO ia ke kumu, hōʻike pinepine ʻia no ka mellitus o ka maʻi diabetes mellitus o kahi ʻano kūʻokoʻa insulin.

Hoʻonui ʻia kāna kūlana e nā mau mea ikaika e lilo i ka wahi o ka lāʻau lapaʻau.

ʻO ka ʻāina kumu o Yanumet ka United States oʻAmelika, e wehewehe ana i ke kumukūʻai nui o nā lāʻau (a hiki i ʻekolu tausani mau rubles, e pili ana i ka dosage).

Hoʻohana ʻia nā papa Janumet i loko o kēia mau hihia:

e hōʻemi i ke kahe o ke koko, inā paha ke kau nei ka meaʻai i ke ʻano me ke ʻano kino kino i hōʻike i ka hopena maikaʻi ʻole.
inā ʻo ka monotherapy e hoʻohana wale nei i kekahi mea ikaika no ka lawe ʻana i ka hopena i makemake ʻia,
Hiki ke mālama ia e like me kahi lā paʻakikī i hui pū ʻia me nā derivatives o sulfrnylurea, insulin therapy a i ʻole nā Antagonist o PPAR-gamma.

Ke loaʻa nei ka lāʻau lapaʻau i kāna hoʻonohonoho ʻana i hoʻokahi manawa ʻelua mau hana ikaika e loaʻa ka hopena hypoglycemic:

ʻO Sitaglipin kahi mea i hui ʻia o ka hui o ka hoʻonaninani DPP-4, ka mea, me ka hoʻonui i ke kō o ke koko, hoʻowalewale i ka synthesis a me ka huna ʻana o nā insulin e nā pancreatic beta cells. Ma muli o kēia kaʻina hana, aia ke emi ʻana o ke kō i nā hoʻohuihui gula i ka nui ole.
ʻO ka Metformin hydrochloride he mea moho o ka hui biguanide o nā kolu o ka mua, ka mea i hāʻawi ʻia i ka pale ʻana o ka gluconeogenesis. Ke hoʻohana nei i ka lāʻau lapaʻau e pili ana i ka mea e hoʻoulu ai i ka glycolysis, kahi e hoʻomaikaʻi ai i ka hoʻomaikaʻi maikaʻi aʻe o ka glucose i nā puna a me nā kiko o ke kino. Eia kekahi, aia kahi wīwī i ka lawe ʻana o ka glucose i nā sela ʻeha. ʻO ka pōmaikaʻi nui o ka metformin ka mea ʻaʻole ia e lilo i ka emi o ka haʻahaʻa o ka glucose (i lalo o ke ʻano kiʻekiʻe) a ʻaʻole i alakaʻi i ka hoʻomohala a hypoglycemia.

Hiki i ka nui o nā lāʻau lapaʻau ke hiki mai ʻelima haneri a i hoʻokahi tausani milligrams o kekahi o nā mea hana - metformin hydrochloride. ʻO ia ke kumu, hāʻawi ka lāʻau lapaʻau hou i nā mea maʻi i nā papa e like me kēia:

ʻO ke kiʻi mua i ka hoʻonohonoho o ka lāʻau lapaʻau e hōʻike ana i ka nui o ka sitaglipin o ka mea hana, ka lua e hōʻike ana i ka hiki o ka metformin. Hoʻohana ʻia nā mea kōkua.

ʻO ka cellulose Microcrystalline.
ʻO Povidone.
Sodium stearyl fumarate.
Sodium lauryl sulfate.
Ka waiʻona Polvinyl, ka titanium dioxide, macrogol, talc, ka oxide iron (ʻo ka ʻōpū o ka hoʻomākaukau ʻana o ka papa i ia mau mea).

Mahalo i ka mea lapaʻau ʻO Yanumet (Yanomed) i hiki, ke hiki ke hoʻokō i ka pale ʻana o ka nui o ka glucoseagon, ka mea, me ka piʻi o ka nui o ka insulin, e alakaʻi ana i ka normalization o ka glucose i loko o ke koko.

He mea nui no ka maʻi maʻi i nā lāʻau a lākou e lawe ai i ka hopena maikaʻi ma ke kumukūʻai haʻahaʻa. Aia a he lāʻauʻokoʻa ka hoʻokaʻawale ʻana i nā mea ikaika, akā aia pū kekahi mau wahi e hui pū ʻia ai nā mea ikaika. ʻOi aku ka maʻalahi o ka hoʻomaʻamaʻa. ʻO kekahi o ia mau mea hana, e like me nā ʻōlelo i hoʻohana ʻia, ʻo ia ʻo Yanumet. E noʻonoʻo e pili ana i kāna hana a me nā mea e wehe ai i nā lāʻau like ʻole i ka mākeke o nā lāʻau antidiabetic.

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana a me ka pōpoki

Loaʻa ia ma ke ʻano o nā papa kiʻi ʻoniʻoni. He 14 mau ʻāpana i loko o kahi blister hoʻokahi, ma kahi pahu kāleka hiki ke loaʻa 1, 2, 4, 6 a i ʻole 7 molohō.

500, 800 a i ʻole 1000 mg o ka metformin,
50 mg o ka sitagliptin monohidate ka phosphate,
mikuleka
povidone
sodium fumarate,
sodium lauryl sulfate.

Ka hana lāʻau lapaʻau

Ma muli o ka hana o nā māhele ʻelua - metformin a me sitagliptin - hoʻonui ʻia ka hopena hypoglycemic o ka lāʻau. Hoʻopau lākou kekahi i kēlā, ka hoʻohaʻahaʻa i ke kō koko.

ʻO ka Sitagliptin kahi mea mālama i ka DPP-4, he hana i hoʻihoʻi i ka incretins, a, ʻo ia hoʻi, e hoʻoponopono i nā glucose homeostasis. Kōkua lākou i ka hoʻonui ʻana i ka huna ʻana o ka insulin inā he pono no kēia ma ke kino. I kēia hihia, ʻo ka ʻiliʻu o ka glukagon a me ka hopena, ke kī ʻia ke kūkaʻomaʻu o ka glucose i loko o ka ate.

ʻO ka metformin kahi nuiuanide e hoʻonui ai i ka hoʻomaloli i ka glucose a hoʻohaʻahaʻa i kona neʻe i ke koko a me ke aʻa ma loko o ke ake. Hoʻohui ʻia, hoʻonui ʻia ka ʻike ʻana o nā pūpū i nā glucose.

Lapaʻau lāʻau

ʻO ka hewa o Yanumet e like me ke kaawale o ka hoʻokele ʻana o ka metformin a me sitagliptin. ʻO ka bioavailability o nā mea mua he 87%, ʻo ka lua 60%.

ʻO ka hana ʻoi loa o sitagliptin mai 1 a 4 mau hola ma hope o ka hoʻokele ʻana. Hana ʻia ka Metformin ma hope o 2 mau hola. Inā ʻaʻole pili ʻia ka hopena o ka mea mua e nā meaʻai, a laila ma ka lua ua hāleo ia mai ka hoʻohui ʻana me ka meaʻai.

ʻO ke ala nui o ka hana excretion ma o nā keiki. ʻO ka liʻiliʻi ka metabolism.

Kākau 2 diabetes mellitus me kaʻai ʻole o ka meaʻai a me ka hoʻomaʻamaʻa.Hiki ke hoʻohanaʻia e like me ka mea hana kūʻokoʻa, a i hui pū paha me ka sulfonylurea a i ʻole insulin.

Nā Hoʻohui

Hypersensitivity o nā māhele,
Nā hana e hoʻopili ai i ka hana o nā keiki maʻi (kūmole, nā maʻi),
ʻAno maʻi type 1
ʻO nā maʻi e alakaʻi i ka hypoxia tissue (myocardial infarction, heart heart),
Hoʻopiʻi ka hana a hoʻomaʻemaʻe paha i ka hana,
Maʻi molaʻi
Alikaihue
ʻŌpū a me ka lactation.

Nā hopena hopena

Nā Aliʻi
ʻO ka pancreatitis
ʻAno, ʻeha ʻeha,
Anorexia
ʻAha metala i loko o ka waha
Lohea
ʻO ka ʻeha a i ʻole a constipation
Putu maloʻo
Allergic hopena pili
ʻEhaʻeha
Kakahi
Anemia
Lactic acidosis
Hypoglycemia,
ʻO ka edema Peripheral.

Ke keu

I ka hihia o kahi overdose, hoʻomohala paha ka lactic acidosis. I kēia hihia, pono ke kāpae ʻia o nā koena o ka lāʻau mai ke kino, a laila hoʻokō ʻia ka hemodialysis a nānā ʻia ke ʻano o ka mea maʻi.

Hiki nō hoʻi ke ʻano o nā hōʻailona o ka hypoglycemia. Me kahi pepa ʻoluʻolu, e pono ai ka papaʻai me ka ʻai i ka momona aʻe. I ka hihia a me ka hōʻeha nui, pono ʻoe e hoʻolilo i kahi pona o ka glucagon a i ʻole ka hopena dextrose, e lawe mai ana i ka mea maʻi i ka ʻike a lawe i ka ʻai i loaʻa nā kīmeka. A laila, he koi no ka hoʻopiʻi ʻana i ke kauka no ka hoʻoponopono ʻana i ka lāʻau e koi ʻia.

Hoʻohui nūhou

E noʻonoʻo e pili ana i ka hoʻopili ʻana o nā ʻano hana ʻē aʻe me kēlā me kēia mehana i kaha ʻo Yanumet.

Hiki i ka metformin ke hoʻonāwī:

nauwe
Kiora
corticosteroids
estrogens
kauilani,
hoʻōla nicotinic
ʻO nā hormones thyroid
nā antagonis kalona
aiaiiaih
haluluHalakalaha
isoniazid.

insulin
Nā NSAID
Ololi Holi,
acarbose,
pili waiwai komo
ʻO MAO a me ACE inhibitors,
huoli
luanuhauna
nā palaka beta.

Hiki i Cimetidine ke pale i ka hana a ka metformin, e hoʻoweliweli ana i ka hoʻomohala ʻana o ka waihala.

Hiki i ka Sitagliptin ke hoʻonui i ka lōʻihi loa o ke kaila o Digoxin, Januvia, Cyclosporin. Basically, ʻo ka launa pū ʻana o kēia mea me nā lāʻau lapaʻau ʻē aʻe, ʻaʻole e hāʻawi i nā mea iʻike nui ʻia e nā maʻi, ʻo ia hoʻi, ʻaʻohe contraindications e hui pū me kahi.

Hiki i ke kōleʻa me ka sulfonylureas a i ʻole insulin mea e hōʻeha i ka hypoglycemia i ka wā e nui aʻe ai ka hopena.

Nā ʻōlelo kikoʻī

ʻO 48 mau hola ma mua a ma hope o nā haʻawina e hoʻohana ana i nā huaʻai iodine, ua hoʻopau ʻia ka lāʻau lapaʻau.

Ma ke ʻano o ka mālama ʻana, pono ia e nānā mau i ke ʻano o nā pūpū a hana maʻamau i nā hōʻike.

Aia kahi pilikia e pili i ka hiki ke lawe i nā kaʻa, no laila he mea pono ke hoʻoholo i ke kūpono o kēia ma ke ʻano o ka mālama ʻana. Loaʻa kēia i nā mea i lawe ʻia me ka insulin a i ʻole sulfonylurea.

Hiki i ka lāʻau lapaʻau ke hoʻoikaika i nā hōʻailona o ka pancreatitis, e hōʻeha i ka pathology renal. No laila, pono e nānā pono ʻia ke kūlana o ka mea maʻi e pale i kā lākou ulu ʻana.

He mea nui ia e ʻike i ka mea maʻi i nā hōʻailona o ka lactic acidosis a inā he mau mea, e hālāwai koke aku i kahi kauka. E pale koke i ka hale hoʻokipa ma ka ulu ʻana o nā ʻōpiopio.

Hoʻokuʻu ʻia ma nā kau wale nō i kau inoa!

Hoʻohālikelike me nā kikowaena

He loaʻa nō kēia lāʻau lapaʻau i nā mea hoʻohālikelike e loea ʻia e heluhelu e hoʻohālikelike i nā waiwai.

Cons: ʻaʻole i hoʻohana pono e mālama i nā wahine hāpai a me nā keiki, i mālama ʻia me ka mālama ʻana i nā maʻi maʻi.

Cons: wale no ka mea maʻi maʻi maʻi, pāpā ʻia i ka wā hapai.

Cons: pāpā ʻia no ka hoʻohana ʻana i nā keiki, nā pākeke, hapai a me ka lactating.

Ke lawe ʻia nei ka hoʻonāukiuki a ka lāʻau lapaʻau a i ʻole ka hoʻohana ʻana i nā analogue me ke ʻae ʻia o ka poʻe loea. Ua papa ʻia ka lāʻau lapaʻau pilikino!

He lāʻau lapaʻau kūpono loa kēia, kūpono hoʻi i ka hapa nui o ka poʻe, a ua hōʻano ʻia ke kumukūʻai kiʻekiʻe e kona kūlana.

ʻO Catherine: "Yanumet" i kuhikuhi ʻia e ke kauka komo. Ua lawe wau iā ia i ʻelua makahiki, hauʻoli wau me nā mea āpau. ʻO kāna hana e kūpono i koʻu, ʻaʻohe ʻano kūlohelohe. Holoi ʻo Sugar a mālama iā ia. Hoʻohui hou, ua hoʻemi ʻia ke paona me 7 kilograms, inā ʻaʻole i loaʻa ka pilikia me ia. "

Daria: “Ua loaʻa iaʻu kēia mau uku ma ka uku no ka manuahi. Ua kūpono lākou i kaʻu, i ka wā i hui pū ai me ka meaʻai a me ka hana kino, hoʻohemo au i 12 kg a hoʻonohonoho i ka pae o ka glucose. ʻOiaʻiʻo, inā wau i kūʻai i kaʻu kālā, he mea paʻakikī ia, he nui ke ʻano. Akā kūpono ke ʻano o ka maikaʻi. "

Igor: "Manaʻo wau he ola ʻo Yanumet no nā maʻi maʻi. Hāʻawi koke ia i nā hopena, me kahi papaʻai a mea hoʻomaʻamaʻa kōkua ia i ke kino i ke ʻano maikaʻi, hoʻohaʻahaʻa i ke kō. Aia ka hopena o ka lawe kaumaha, akā ua wehewehe ʻo ke kauka ʻaʻole hiki iā ʻoe ke inu i kēia mau pāʻai wale no ia wale nō - ua ikaika ka kaumaha ma luna o nā. "Maikaʻi nā mea āpau iā lākou, no laila ke hoʻomau nei au i ka mālama ʻana i kēia lāʻau lapaʻau a hauʻoli wau i nā hopena."

Nā Poʻomaʻo: “Ua ʻike ʻia koʻu makuakāne me ka maʻi diabetes. Ua hoʻokaʻawale mua ke kauka i ke metformin a me kahi sitagliptin i hoʻokaʻawale. A laila maopopo iā lākou aia kekahi lāʻau lapaʻau e pani i nā papa ʻelua, ʻoiai ua loaʻa nā mea ʻelua o kēia mau mea. Ua ola kino nā keiki o kona makuakāne, no laila ua ʻae ke kauka iā ia e lawe ʻia. Ua kōkua maikaʻi ʻo "Yanumet" i ka hoʻohālikelike ʻana i ke kō, a me ke kau ʻana i ke kaumaha nui i ʻike ʻia mai ka makuakāne no ka maʻi. Ua hopohopo lākou e loaʻa nā hoʻopiʻi i ka lolo a i nā hopena ʻē aʻe paha, akā hiki iā lākou ke hana me ke ʻole o lākou. Ua ʻoluʻolu ʻo Papa me kēia lāʻau lapaʻau, mālama ʻia ʻo ia i kēia lā. "

Hoʻohālikelike

He maikaʻi nā loiloi a Yanumet mai nā maʻi maʻi maʻi a me kā lākou mau kauka. Hāʻawi kēia hopena no ka maʻi diabetes i ka hopena wikiwiki a mau loa, kūpono no nā poʻe he nui a aneane ʻaʻole ia e hoʻokū i ka hopena ʻino. Ua hoʻonani ʻia ʻo ia no ka kiʻekiʻe a me ka loaʻa o nā pono pōmaikaʻi, ʻoiai ke hoʻomaopopo ʻia he kiʻekiʻe ke kumukūʻai ma nā lāʻau lapaʻau maʻamau. Akā ʻo ka hana pono o ka lāʻau lapaʻau e uku no kēia drawback.

Hoʻopiʻi nā papa Yanumet no ka hoʻohana ʻana i nā lāʻau hypoglycemic i hoʻohana ʻia no ka hoʻopiʻi ʻana i nā maʻi maʻi type 2. Hoʻonui ʻia kāna kūlana e ke ʻano kū hoʻokahi o ka huahana. ʻO wai ka mea kūpono no a pehea pehea e hoʻohana pololei ai?

ʻO ka maʻamau ke kuhikuhi ʻia inā nā loli o ke ola a me ka ʻoi aku ka metformin monotherapy a i ʻole ka hoʻopiʻi ʻana i ka hopena hoʻokō. Ma kekahi manawa e kuhikuhi ʻia i nā poʻe e pili ana i ka haʻuki no ka mālama ʻana i kā lākou glycemic profile. Ma kahi o kahi familiarization kikoʻī me nā ʻōkuhi, ma mua o ka hoʻohana ʻana i kēlā me kēia kūlana, he kauoha ke kauka.

Yanumet: hoʻonohonoho a me nā hiʻohiʻona

ʻO ke kumu hana ikaika i loko o ka pulu ʻo metformin hydrochloride. Hoʻopili ʻia ka lāʻau lapaʻau i ka 500 mg, 850 mg a i ʻole 1000 mg i 1 papa. Hoʻokomoʻo Sitagliptin i ka mea kanu kūpono, i loko o hoʻokahi pahu e hoʻonui ai iā 50 mg i kekahi mauʻu o ka metformin. Loaʻa nā mea hoʻonani ma ka hopena no ka mea ʻaʻole hoihoi i ka hua o nā lāʻau lapaʻau.

ʻO ka pale mau convex elongated e mālama ʻia mai i nā fakes me ka palapala "575", "515" a i ʻole "577", e pili ana i ka dosage. Aia i kēlā me kēia pahu pahu pepa ʻelua a ʻehā paha o nā ʻāpana 14. Hoʻolaha ka lāʻau lapaʻau.

Hōʻike ka pahu i kahi ola o ke ola o ka lāʻau lapaʻau - 2 mau makahiki. Pono e hoʻokaʻawale ʻia nā lāʻau lapaʻau. He pono nā koi no nā kūlana mālama: he wahi maloʻo ʻole ʻia i ka lā a me nā keiki me kahi keʻena wela a hiki i 25 degere.

Hiki i nā pono Pharmacological

ʻO Yanumet kahi manaʻo noʻonoʻo i ʻelua mau lāʻau lapaʻa me ka hoʻohaʻahaʻa i ka haki (a hoʻohui ʻia i kēlā me kēia ʻano): metformin hydrochloride, kahi hui o ka biguanides, a me sitagliptin, he mea hoʻohui o DPP-4.

Synagliptin

Mālama ʻia ka ʻenehana no ka hoʻohana waha. Hoʻokumu ʻia ka hana o ka hana o sitagliptin i ka hoʻoulu ʻana o incretins. Ke hoʻokaʻawale ʻia ka DPP-4, ke piʻi aʻe o ka pae o GLP-1 a me Hept peptides, nāna e hoʻoponopono i ka homeostasis glucose. Inā he hana maʻamau kāna hana, hoʻoulu ʻia e ka incretins i ka hana ʻana o ka insulin e hoʻohana ana β-cells. Hoʻopili hoʻi ka GLP-1 i ka hana ʻana o glucagon e nā pona-α i loko o ka ate. ʻAʻole like kēia algorithm i ke kumu o ka hoʻolaha ʻana i nā lāʻau lapaʻau paʻahana sulfonylurea (SM) e hoʻoikaika i ka hana o ka insulin i kekahi pae glucose.

Hiki i kēlā ʻano hana ke kumu i ka hypoglycemia ʻaʻole wale i ka maʻi maʻi, akā i nā mea hoʻohiki olakino.

ʻO ka inhibitor enzim DPP-4 i loko o nā papa i ʻōlelo ʻia ʻaʻole ia e pale i nā hana o ka PPP-8 a i ʻole PPP-9 i nā enzyme. I loko o ka lāʻau lapaʻau, ʻaʻole like ka sitagliptin i kāna mau kikoʻī: GLP-1, insulin, SM derivatives, meglitinide, biguanides, α-glycosidase inhibitors, γ-receptor agonists, amylin.

Mahalo i metformin, hoʻemi i ke kōkō ma ke ʻano maʻi maʻi type 2: ke hoʻemi nei ko lākou koʻikoʻi (a i ʻole ka postprandial a me basal), a laila e emi ana ka pale ʻana i ka insulin. He ʻokoʻa nā ka algorithm o ka hopena o ka lāʻau lapaʻau ma nā loiloi o ka hana o nā lāʻau lapaʻau haʻahaʻa e hoʻohiolo ana. Ke hōʻike nei i ka hana o ka glucogen e ka ate, hoʻohaʻahaʻa ka metformin i ka hoʻopili ʻana e nā paia o ka ʻōpū, hoʻemi i ka kū i ka insulin, hoʻomaikaʻi i ka upipake peripheral.

ʻAʻole e like me ka hoʻomākaukau a SM, ʻaʻole ka hoʻonāukiuki i ka pahuhopu o nā hyperinsulinemia a me ka hypoglycemia ʻaʻole i nā maʻi maʻi me ka maʻi type 2, a i ʻole i ka pūpū kaohi. I ka wā o ka mālama ʻana me ka metformin, e noho pū ana ka hana o ka insulin i ka pae like, akā ʻo ka wikiwiki a me ka pae ʻana o kēlā me kēia lā e emi ana.

Kapehu

ʻO ka bioavailability o sitagliptin he 87%. ʻAʻole ka hopena o ka hoʻohana ʻana i nā meaʻai momona a me nā kiʻekiʻe o ka calorie ma ka nui o ke kao ʻana. ʻO ka pae kiʻekiʻe o ka mea i loko o ke kahe koko e paʻa i nā hola 1-4 ma hope o ka hoʻomoʻa ʻana mai ka gastrointestinal tract.

ʻO ka bioavailability o ka metformin ma luna o kahi ʻōpū ʻūlū a hiki i 60% ma kahi o 500 mg. Me ka hapa hoʻokahi o nā wai kūʻokoʻa (a i ka 2550 mg), ka lula o ka proportionality, ma muli o ka haʻahaʻa haʻahaʻa. Metformin hele mai i ka hana ma hope o ka manawa ʻelua a me ka hapa. Ua hōʻea kona pae i 60%. ʻO ka palena kiʻekiʻe o metformin e hoʻoponopono ma hope o hoʻokahi lā a i ʻole ʻelua. I ka wā ʻai, hōʻemi ka maikaʻi o ka lāʻau.

Kahele

ʻO ka nui o ka hoʻonuiʻana i ka synagliptin me kahi hoʻohana hoʻokahi o 1 mg o ka hui mana o nā mea komo i ka hoʻokolohua ʻo 198 l. ʻO ka pae nui o ka naki i nā protein koko he liʻiliʻi iki paha - 38%.

Ma nā hoʻokolohua like ʻole me metformin, hāʻawi ʻia ka pūʻulu mana i ka lāʻau lapaʻau ma ka nui o 850 mg, ka nui o ka puunaue i ka manawa like me ka awelika o 506 lita.

Inā mākou e hoʻohālikelike me nā lāʻau lapaʻau o ka papa SM, ʻike pinepine ʻia ka metformin e hoʻopaʻa ʻole i nā protein, he manawa liʻiliʻi kekahi mahele o ia wahi i loko o nā ʻāpana koko ʻulaʻula.

Inā lawe ʻoe i ka lāʻau lapaʻau i loko o kahi kikoʻī, kūpono kūpono (