ʻO ka lāʻau Glibenclamide no ka maʻi maʻi - kauoha no ka hoʻohana ʻana

ʻO ka maʻi mellitus type type 2 he maʻi multifactorial maʻamau, i hōʻike ʻia e ka pale hewa o ka metabolism kalepa. ʻO ke kumu nui o ka mālama ʻana i ka hana pilikino, ka mālama ʻana i ka meaʻai, nā lāʻau lapaʻau. ʻO kekahi o nā lāʻau lapaʻau i kauoha ʻia no ke ʻano type type 2 he glibenclamide.

ʻO ka ʻike nui o ka lāʻau lapaʻau

ʻO Glibenclamide kahi lāʻau mālama gula i ʻike ʻia i hoʻolaʻa ʻia i hoʻohana ʻia ma nā ʻāina ʻē, i ka Rusia hoʻi, mai ka hoʻomaka ʻana o 70s. ʻO ia kahi mea hoʻohālike o nā derivatives o ka sulfonylurea (2 mau hanauna). Hoʻohana nui ʻia ka lāʻau lapaʻau e mālama i nā maʻi maʻi type 2.

Hōʻike ka hōʻike i hōʻike ʻia i nā waiwai hou aʻe no ke kino. I nā makahiki i hala 45 mau makahiki, ua hoʻonui hou i nā lāʻau antidiabetic a me nā lāʻau lapaʻau me nā ʻano hana like ʻole i kū mai ma ka mākeke pharmacological. Akā, ʻo Glibenclamide ke kuhikuhi ʻia e nā kauka a ʻaʻole e nalowale i kona hānai.

ʻAʻole like me kona mea i mua o ka wā, ʻoi aku ka maikaʻi o ka lāʻau lapaʻau a ikaika. Ua hōʻike ʻia ma ka waiho ʻole ʻana o ka hopena o ka lapaʻau ʻana me ka pale ʻole ʻana i nā lāʻau lapaʻau ʻē aʻe.

ʻO nā hiʻohiʻona Pharmacological a me keʻano

ʻO ka hopena o ka lāʻau lapaʻau ka hypocholesterolemic, hypoglycemic. Hoʻonui ia i ka nui o ka hoʻonui ʻia o ka insulin e ka pancreas, hoʻōla ikaika i ka hana o nā poli beta o ka ʻāpana islet. Hoʻopili ka mea i nā pā pākōlani e hilinaʻi nei (nā kaila ATP).

ʻO ka hoʻokūkū o nā polikona huna me ka insulin e hele a, ma ka hopena, ke komo ʻia nā mea ola ololi i ke koko a me ke ʻano intercellular.

Hoʻohui i ka hopena nui, loaʻa ka hopena i kahi hopena thrombogenic a hoʻohaʻahaʻa i ka kolamu. Hāʻawi i kahi wikiwiki a me ka hoʻihoʻi ʻana i ka pānaʻi ʻana. ʻO ka nakinaki ʻana i nā protein plasma e hele kokoke a kokoke i (98%). Hoʻāluā ka lāʻau i ka ate. Loaʻa ka pae kiʻekiʻe loa i ke koko i loko o 2 mau hola.

Kono ia ka mea no 12 mau hola. ʻO ka hapalua-ola ma hope o ka mālama waha ʻana he 7 mau hola, hoʻopau i 2-3 mau lā. Hoʻokuʻu ʻia ia ma ka bile a me ka urine Me ka hoʻohaʻahaʻa ʻana i ka hana o nā ate, hiki i ka excretion ke iho i lalo, a me ka hina o ka papaha, ma ke kaawale, hoʻonui ʻia ka nui.

ʻO ka inoa o ka mea ikaika ma ka ʻōlelo Latin he glibenclamide. E hoʻokuʻu i nā palapala: nā papa pāwili papahele. Loaʻa kēlā me kēia pae i 5 mg o ka mea hana.

Nā hōʻailona a me nā contraindications

Hōʻike hōʻailona no ka hoʻohana ʻana: ke kaila like ʻole-insulin, i hāʻawi ʻia ʻaʻohe hopena o ka hoʻoponopono ʻana i ka glucose e ka lāʻau mālama lāʻau.

Nā ʻōmole o ka hoʻohana ʻana:

kealoli i ka mea ikaika,
lawelawe aho ʻaia,
ka hana ʻaʻama me ka makemake o ka hoʻoneʻe i ke kino,
precoma a pōmaika coma,
hapai
huakaʻi renal function,
lactation
hana paʻa pau ʻole
diabetes-hilinaʻi i ka lolo (DM 1),
nā kānaka ma lalo o 18 makahiki.

Nā ʻōkuhi no ka hoʻohana

Ke lawe ʻia nei ka loli i ka glibenclamide, ʻōlelo ʻia ka lāʻau me nā papa he 0.5 i kēlā me kēia lā. Hoʻomaopopo ka poʻe'ōpiopio me ka hana ʻole o nā mea a pau i ka holomua e hoʻolālā.

He mea kūpono kēia no ka poʻe ke kaupaona ʻana a 50 kg. I ka lā, ma ke ʻano he 2.5-5 mg o ka lāʻau (a hiki i ka 1 papa). Inā pono, e hoʻonui i ka wīwī. ʻO nā palena maʻamau i kēlā me kēia 3 papa.

Lawe ʻia ka lāʻau lāʻau ma mua o ka papaʻaina. Ma ka hapa o ka ʻoi aku ma mua o ka 1 papa papa, ʻia e ʻimi ai i kahi kiko o 2: 1 (kakahiaka: ahiahi). Hoʻomaka ʻia ka kiʻi ʻia i ka manawa hoʻokahi me ka haki ʻole. I ka wā o ka mālamaʻana, ka nānāʻia o ka pae o ka metabolism.

Me ka makaʻala, pono e hoʻohana ʻia ka lāʻau lapaʻau e nā ʻano o nā maʻi i lalo.

elemakule
kanaka me ka pīhoihoi hana pāpaʻi,
nā mea maʻi me ka hoʻemi ʻana i ka hana thyroid,
me nā hōʻailona o ka sclerosis cerebral.

Ma ke kīleʻa i ka wā o ka mālama ʻana i ka hana ʻōnaehana hiki ke hoʻopilikia i ka ambiguously - e hoʻomaikaʻi ai a hoʻonāwaliwali i ka hopena o ka lāʻau. Hoʻokomo ka Dye E124 i nā maʻi kūlohelohe i nā mea maʻi hiki. Inā loaʻa kekahi maʻi (a i ʻole) loaʻa, pono ia e hōʻike i ke kauka. ʻAʻole hiki i nā mea maʻi ke ʻoki kū ʻole i ka lawe ʻana i ka lāʻau a hoʻoponopono paha i ka ʻoka me ke ʻole ke kūkā ʻana i kahi kauka.

Nā hopena ʻaoʻao a me ka overdose

I waena o nā hopena hopena:

loaʻa ka paona
ka luaʻi, ka lua, ke kaumaha ʻana i ka hoʻowalewale ʻana, ka ʻōpū ʻana,
ka ʻeha manuʻala, ʻeha, anemia,
lawelawe aho ʻaia,
hoʻonui i nā hiʻohiʻona biochemical,
ʻike maka
huahuʻi,
nā hopena kūlohelohe
thrombocytopenia, leukocytopenia, erythrocytopenia, granulocytopenia,
nā hopena diuretic palupalu.

ʻO ka overdose (hoʻonui i ka wā liʻiliʻi a i ʻole hoʻokahi manawa manawa e hoʻonui ai i ka wai) i nā nui he nui e alakaʻi ana i ka hypoglycemia.

kaohuu
a palapa o ka ʻili
mākaukau ka ʻōlelo, a me ka noʻonoʻo
palpitations, uhaki,
me kahi holomua holomua - hypoglycemic coma.

I nā kūlana koʻikoʻi, pono ia e holoi i ka ʻōpū a hoʻoiho i kahi puna o ka glucose. Inā pono, e lawelawe ʻia ka glucagon. Hiki ke hoʻopau ʻia ka hypoglycemia ʻeha ma kāna iho ma ka ʻai ʻana i ke kō.

Hoʻopili pū kekahi me nā lāʻau lapaʻau a me nā hōʻailona

ʻO nā lāʻau lapaʻau e hoʻonui ai i ka hopena o Glibenclamide e loaʻa: Miconazole, tetracycline antibiotics, anabolic steroids, antidepressants, insulin a me ka nui o nā mea maʻi diabetes, nā kāne kāne.

ʻO nā lāʻau lapaʻau e hōʻemi i nā hopena e loaʻa i nā: thyroid hormones, corticosteroids, nicotinates, glucagon, beta-andrenoblockers, wahine sex hormones, diuretics, barbiturates.

ʻO nā lāʻau lapaʻau e hiki ke hoʻopilikia i ka glibenclamide (hoʻoikaika a, ʻole, hoʻohaʻahaʻa, haʻahaʻa) i nā: Clonidine, Reserpine, H2 receptor blockers, pentamidine.

ʻO nā lāʻau lapaʻau o nā hana like:

ʻO ka hoʻohālikelike kikowaenaʻo Maninil (ʻo ka hana ikaika ua like).
hui o nā lāʻau lapaʻau me ka glimepiride - Amapirid, Amaril, Glibetic, Glimax, Diapride,
hoʻomākaukau me ka Gliclazide - Glidia, Glicada, Gliclazide, Diagnizid, Panmicron-MV,
kālā me Glipizidom - Glynez, Minidiab.

Nā kumuhana wikiō mai Kauka Malysheva e pili ana i nā huahana e hōʻemi i ke kō i ka maʻi diabetes a hiki ke hoʻohana ʻia ma ke ʻano he lāʻau lapaʻau:

ʻO nā manaʻo hoʻomanawanui

Mai nā loiloi o nā mea maʻi e lawe ana iā Glibenclamide, hiki iā mākou ke manaʻo e uku kūpono ke kumukūʻai o ka lāʻau a hōʻemi loa ia i ke kō, akā ma hope o kona hoʻohana ʻana, e hele pinepine ʻia nā hopena o ke ʻano o ka nausea a me ka ʻole o ka makemake.

Ua maʻi wau me ka maʻi hānai no nā makahiki 12. Ua kuhikuhi ʻia nā ʻano lāʻau like ʻole, akā ua hōʻoia ʻo Glibenclamide ka mea kūpono loa. I ka manawa mua i mālama ʻia lākou me Metformin - ʻaʻohe hopena koʻikoʻi ma ka maʻamau o ke kōpila ma hope o ka hāpai ʻana i ka dosage. Ma hope o ka hoʻokuʻu ʻia o Glibenclamide. ʻO ka hopena ʻaoʻao ma ke ʻano o ka nalowale o ka makemake a me ka maʻi nausea i ka malama mua, a laila hoʻi hou nā mea a pau. ʻO ka pae momona i ka wā o ka hoʻohana ʻana i ka lāʻau lapaʻau e hōʻemi a mālama i loko o ka lā 6. I ka manawa uaʻike au i kahi maʻamau, a ʻoluʻolu ia.

Irina, 42 makahiki, ʻo Samara

Ua loaʻa mua koʻu makuahine i ka maʻi diabetes type 2. Ua kuhikuhi koke aku i ke kauka hele i Glibenclamide a kuhikuhi i kahi papa inoa. Ma kahi hebedoma ma hope o kona hoʻohana ʻana, hoʻomaka wau e hōʻeha i ka maʻi me ka nele o ka momona. Akā, e like me kāna i ʻōlelo ai, ʻaʻole pili nui kēia i ka neʻe o ka glucose i mālama ma 6-7. I ka wā mālama, ʻoi aku i nā pae glucose, pono ia e nānā i nā ʻāpana ʻāpana. Akā, ʻoluʻolu ke makuahine, a me Glibenklemin, maikaʻi.

Sergey, 34 makahiki, Yekaterinburg

ʻO koʻu maʻi maʻi he 6 mau makahiki ka nui. ʻAʻole hiki ke hoʻoponopono ʻia ka glucose. Pono wau e koho i kahi lāʻau. ʻIke wau i ka hopena mai Glibenklemin wale nō - ua hoʻemi ʻia ka meli i ka 6.5. (Ke hoʻohana mau nei au i ka mika). Ma mua o kēlā manawa, ʻaʻole hiki iaʻu ke hoʻokō i kēlā me kēia hōʻailona e like me ka manawa lōʻihi, ma lalo o ka 7 gula i emi ʻole ai. I ka hope ua ʻohi au i kaʻu lāʻau. I ka wā mua ua loaʻa iaʻu ka paona liʻiliʻi, akā laila hoʻoponopono wau i kaʻu meaʻai. I waena o nā hopena hopena: ka manawa maʻamau, ka manawa maʻamau - ka maʻi maʻamau a me ka nalowale i ka makemake.

Oksana, he 51 makahiki o Nizhny Novgorod

ʻO ke kumukūʻai o ka lāʻau kanu mua ma waena o 90 a 120 mau rubles. Hoʻokuʻu ʻia ka lāʻau lapaʻau ma o nā lāʻau wale nō.

ʻO Glibenclamide kahi lāʻau lapaʻau kūpono no ka hoʻohaʻahaʻa i nā pae haʻahaʻa. A ʻōlaʻi ʻia ia e nā kauka a ʻaʻole nalowale i kona hānai, ʻoiai me ka loaʻa o nā lāʻau lapaʻau o kahi palapala hou.

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana a me ka pōpoki

Loaʻa ka Glibenclamide i ke ʻano o nā papa o ke keʻokeʻo, ʻeleʻele a i ʻole a hina hina paha, kahi ʻano cylindrical pāwili ʻia me ke kāʻei piʻoloke ma waena.

Aia nā papa i nā poli me nā pūpū (10 pcs.), Aia i loko o kahi pahu pahu. ʻO nā papa o 20, 30, 50 mau papa e hiki ke kāʻei ʻia i loko o nā ʻāpana palaki a i ʻole ke aniani ʻōmole.

1 ka papaʻu i ka 5 mg o ka glibenclamide - nā mea ikaika. E like me nā mea hoʻohui hou, ka waiū waiū (lactose monohydrate), povidone, starch potato, magnesium a me calcium stearate i loaʻa.

Hoʻopili maikaʻiʻia ka wai a me ka waiʻona.

Hōʻike ka loiloi o ka mākeke lāʻau kūʻai e kūʻai nui ʻia ana ke kumukūʻai o ka lāʻau lapaʻau i ka mea hana hana a me ke kahua o ke kūʻai aku. No laila, ma Moscow, kahi a me St. Petersburg i hōʻike ʻia nā huahana kūloko i nā awelika o 30-70 rubles, lawe ʻia (India) - mai 90 mau rubles.

I nā wahi, ʻoi aku ka kiʻekiʻe o ka lāʻau lapaʻau. No laila, ua kūʻai ʻia ʻo Glibenclamide i Rūkia mai 96 mau rubles, a hoʻokomo ʻia - 130-1140 mau rubles.

Ka hana lāʻau lapaʻau

Oral derivative o ka lua o ka hui sulfonylurea. Loaʻa ia i ka hypoglycemic (hana i ka hoʻokaʻina o ke koko) a me ka hana hypocholesterolemik (lowers cholesterol).

E like me nā lāʻau maʻi maʻi ʻē aʻe, ʻo Glibenclamide e hoʻoulu i nā cell pancreatic e hana ana i ka insulin. ʻAʻole like me nā lāʻau lapaʻau mua, hōʻike ʻia e ka hana kiʻekiʻe (ʻo ka hopena ka wikiwiki me ka pākahi no lalo) a laila, ke kamaʻilio maikaʻi ʻia ʻana.

Hoʻololi i ka mālamaʻana i nā hua beta pancreatic e loli i ka nui o ka glucose i ke koko. Hoʻonui ia i nā mea insulin i ka plasma a hoʻohaʻahaʻa i ka nui o nā mea hope o ke koko. Lawe ʻia ke kaʻina hana maʻamau me ka maikaʻi ʻole, me ka kumu ʻole hypoglycemic kūlana. Hoʻonui i ka nui o ka hoʻokaʻawale i ka glucose i nā mākala a me ka puʻuwai, e hoʻopili i ka hoʻokumu ʻana o ka glycogen (kahi hōʻemi paʻakikī) i loko o lākou. Hoʻemi ia i ka hoʻoneʻe ʻana o nā lipids, ka hoʻoponopono i ka lipolysis ma ka adipose tissue, loaʻa kahi hopena antidiuretic, e hoʻemi ana i ka hōʻemi o nā koʻi koko.

Me ke kū'ē o ke kino i nā lāʻau lapaʻau o kēia pūʻulu, ʻoi aku ka maikaʻi o ka glibenclamide. Hoʻomohala ka mea kiʻekiʻe o ka hana therapeutic ma hope o 1-2 mau hola, hiki i ka lōʻihi ma hope o 7-8 hola, a mau aku 8-12 mau hola.

Lapaʻau lāʻau

Hoʻopau piha loa ka mea ikaika mai ka gastrointestinal tract. Ma kahi o 100% e paʻa ai i nā protein plasma. ʻO ka hoʻopau ʻana hapa-ola e hana i nā hola 4-11. I loko o nā ate, ua wāwahi i lalo o ʻelua mau mea e hana ai: hoʻihoʻi ka mea i ka urine, ʻo ka lua - me ka bile ma o ka huehue.

ʻOi aku ka maikaʻi o ka lāʻau lapaʻau i ka paʻu placental.

nā mea maʻi me ka maʻi diabetes type 2 in case of inefficiency of diet diet,
me ka pale ana o ke kino i na laau e ae o keia hui;
nā mea maʻi e hoʻohana ana i nā ʻāpana he 30 o ka insulin i kēlā me kēia lā,
i ka hui me ka insulin.

Nā Hoʻohui

maʻi diabetes type 1
hypersensitivity i nā māhele o ka lāʻau lapaʻau,
ketoacidosis
precomatous
renal a me ka nele ole,
leukopenia
ʻōpū ma mua,
ka hoʻohālikelike ʻana o nā pūpū,
ālai ʻole,
hoʻōki kūloko
nā maʻi ʻohi
hapai a lactation.

Nā helu a me ka noi

Pono e kiʻi ʻia ʻo Glibenclamide i mau manawa 3 i ka lā 20-30 mau minuke ma mua o ka ʻai, inu ka wai nui.

I ka mua, ʻo kēlā me kēia lā he 2.5 mg i ka lā. I ka loaʻa ʻole o nā hopena piʻokeʻo a me ka hoʻokō i ka hopena therapeutic e makemake ʻia, e hoʻonui ikaika ka nui i loko o ka manawa 2 i hoʻokahi manawa i hoʻokahi mahina.

Hoʻokomo ka lāʻau mālama mālama i ka 5-10 mg no ka lā, akā ʻaʻole iʻoi aʻe ma mua o 15 mg.

Nui! No nā poʻe maʻi maʻi, ʻo ka lālapa o kēlā me kēia lā he 1 mcg.

Nā ʻōlelo kikoʻī

Pono ka lāʻau i ka manawa like.

I ka wā hana, pono ka mālama mau ʻana i nā pae glucose. I ka hoʻomākaukau ʻana no ka hana a me ka manawa mua ma hope o lākou, me ka wā hapalua hoʻi, pono ia e haʻalele iā Glibenclamide a hoʻololi i ka insulin. Pono e hāpai i ka noʻonoʻo e hoʻemi i ka hana o nā mea contraceptives a me glucocorticosteroids i ka hopena o ka lāʻau lapaʻau, a hoʻonui nui nā beta-blockers.

Me ka hoʻohana maʻamau o ka lāʻau lapaʻau, mea nui e hahai i ka meaʻai a me ka lā. Pono ʻoe e haʻalele ʻalo i ka waiʻona.

Me ka mālama aka, ua kuhikuhi ʻia ka lāʻau lapaʻau i nā mea maʻi me ka maʻi aho a me ka hana pāpaʻa.

Hoʻohālikelike me nā kikowaena

I waena o nā lāʻau lapaʻau me ka hopena like, aia nā:

ʻOkoʻa ka Glyclazide mai Glibenclamide me ka ʻike like pū. Hoʻohana ʻia ia no ka ʻano like o ka maʻi diabetes. He mauʻuʻuku nā contraindications e hoʻohālikelike ʻia i kona kahe. Haalele ʻia mai 18 mau makahiki.

ʻO ka maʻi Diabeton kekahi mea ikaika, e like me ka lāʻau ma mua, - gliclazide. Aneane aneane aneane aneane ʻomi.

Diadeon. ʻO ka mea waiwai he gliclazide hoʻi. Kōkua i ka hoʻemi ʻana i ke koko o ke koko, a e hōʻemi ana hoʻi i ka nui o ke kōʻai koko i loko o nā moku liʻiliʻi.

Kuiluna. Hoʻāka ʻē aʻe ia mai ka ʻano ikaika o ka mea i hōʻike ʻia ma luna nei, i kapa ʻia ʻo "glycidone". Ua hana ʻia no ka maʻi type II.

ʻO Glibenclamide, ʻaʻole e like me nā analogue, e hōʻemi hou aku i ka cholesterol a pale i ka thrombosis.

Hōʻike ka loiloi o nā loiloi he maikaʻi loa ka lāʻau, loaʻa iā ia me kahi hōʻike liʻiliʻi o nā hopena ʻaoʻao. E hoʻohaʻahaʻa i nā haʻahaʻa holi.

Ma nā loiloi, e kūkākūkā nui nā mea maʻi me ka maʻi a me ka hoʻopili ʻana me nā lāʻau ʻē aʻe ma ka hui pū ʻana.

Hoʻomaopopo nā poʻe loea he ʻokoʻa a kēlā me kēia hihia, no laila he hiki ʻole a kuhi hewa e kuhikuhi i ka mālama ʻana i ka absentia.

Ke koho nei i ka hoʻomaʻamaʻa kiʻekiʻe a me ka maikaʻi e pono ai i kekahi manawa e hana i ke aʻo ʻana i nā keʻehana, e hoʻomālamalama i ka dinamics o ka maʻi. Ma hope o kēia hiki iā mākou ke hōʻea i kekahi a i ka hoʻoponopono lāʻau hou paha.