NovoMix 30 Flexpen: nā ʻōlelo no ka hoʻohana ʻana, contraindications, kumukūʻai, nā loiloi, nā wehewehe, nā hopena pili

ʻO ka pūnaewele mana o ka hui RLS ®. ʻO ka hoʻolaha nui o nā lāʻau lapaʻau a me nā huahana o ke kākāʻā o ka mea kūʻai aku i ka Pūnaewele Lūkia. Hāʻawi ka hua'ōlelo o Rlsnet.ru i nā mea hoʻohana me ke komo i nā ʻōkuhi, nā kumukūʻai a me nā wehewehe o nā lāʻau lapaʻau, nā mea hoʻoulu ai i nā meaʻai, nā pono olakino, nā lāʻau lapaʻau a me nā mea'ē aʻe. Hoʻokomo ka papa kuhikuhi i ka lāʻau lapaʻau e pili ana i ka ʻike a me ka puka o ka hoʻokuʻu, ka hana a ka lāʻau lapaʻau, ʻike mau no ka hoʻohana ʻana, contraindications, nā hopena ʻaoʻao, ka pili o nā lāʻau lapaʻau, nā ʻano hana o nā lāʻau lapaʻau, nā lāʻau lapaʻau. Aia i ka papa kuhikuhi ka lāʻau lapaʻau nā kumukūʻai no nā lāʻau a me nā huahana lāʻau lapaʻau ma Moscow a me nā kūlanakauhale Lūkini.

Ua pāpā ʻia ʻo ka hoʻoili ʻana, kope, hoʻoheheʻe ʻia ka ʻike me ka ʻole i ʻae ʻia ʻo RLS-Patent LLC.
I ka helu ʻana i nā ʻike ʻike i paʻi ʻia ma nā ʻaoʻao o ka pūnaewele www.rlsnet.ru, pono kahi loulou i ke kumu o ka ʻike.

ʻOi aku nā mea hoihoi aʻe

Iwai a aie ke dttla.

ʻAʻole ʻae ʻia ka hoʻohana ʻana i ka ʻoihana.

ʻO ka ʻike e hana no nā lāʻau lapaʻau.

Nā ʻatikala pili

Nā hopena Dioxidine no ka maʻi maʻi

Kaukaoma Victoza: nā ʻōlelo hoʻohana no ka hoʻohana ʻana

Pehea e mālama ai i ka maʻi maʻi me Tiogamma?

ʻO ke kumumanaʻo o ka lāʻau Novomix

Ke hoʻokomo nei ka lāʻau lapaʻau i nā pale lāʻau i nā pahu lāʻau a i ʻole he peni syringe kūikawā. ʻO ka nui o nā puka dosage he 3 ml. ʻO ka papa ʻaina he 2 mau ʻāpana.

I ke komo ʻana, ka lāʻau lapaʻau:

1. Hoʻokomo ʻia nā ʻenehana insulin,
2. Mālama i ka hana ikaika o ke kō,
3. Hoʻemi i ke kōpili koko
4. Hoʻonui kūlike i ka pae o ka glucose, e kū mālie loa a ma hope o ka ʻai.

ʻAʻole pili ka lāʻau lapaʻau i ka hiki ke loaʻa nā keiki a ʻaʻole i alakaʻi i ka hoʻomohala ʻana o nā mutations a me nā maʻi tumeka. ʻO Novomix kahi lāʻau palekana e loaʻa pinepine i nā hopena ʻaoʻao ke hoʻohana pono ʻia.

ʻO ka hormon, kahi kumu o ka lāʻau lapaʻau, e like like me ka insulin kūlohelohe a no laila ʻaʻole hoʻonā i kahi hoʻoweliweli i ke kino.

Nā Contraindications, e hoʻohana ana i ka wā e lawe a hānai i kahi keiki

Hoʻokomo ʻia ka lāʻau i ka hihia o ke hypersensitivity i ka aspart o ka insulin a i ʻole nā ​​mea kōkua. ʻAʻole kuhikuhi ʻia ka lāʻau lapaʻau no nā keiki ma lalo o 6 makahiki. Ke lawe nei i kahi keiki, ua hoʻokaʻawale ʻia ka Novomix i nā hihia pōmaikaʻi o ka nui o ka ʻeha no ke keiki hānau ʻole.

Ke lawe nei i kahi keiki, e kiaʻi ponoʻī i ka pae o ka glucose i ke koko a hoʻomau mau ia. I ka lā mua o ka mākō ʻae i ka hapai ʻana, ua hōʻole ʻia ka noi i ka insulin, i ka lā 2 a ua hoʻonui hoʻi i ka trimester 2. Ma hope o ka hānau keiki ʻana, hiki ke hoʻēmi ʻia ka nui o ka make, no ka mea, ʻoi aku ka makemake o ke kino no ka insulin.

Loaʻa nā hopena ʻaoʻao

Me ka hoʻohana ʻole kūpono a lōʻihi paha, hiki i ka Novomix ke hoʻopōʻino i ke kino o ka mea maʻi. Hōʻike nā maʻi i nā hopena i makemake ʻole ʻia:

1. Hypoglycemia. ʻO kēia ke ʻano i ka hāʻule ʻana o ka hāhi koko i ke kuhikuhi i nā kuhikuhi pathological (ma lalo o 3.3 mmol no 1 lita). Hoʻokomo ka Hypoglycemia i kēlā mau maʻi i hāʻawi ʻia i kahi kiʻekiʻe loa o nā lāʻau. Hōʻike koke nā hōʻailona o ka meli haʻahaʻa. E lilo ka ʻili, hoʻomaʻemaʻe mau ke kanaka, wikiwiki e ʻeha a loaʻa i ka hopohopo nui. ʻO ka poʻe maʻi me ka hoʻohaʻahaʻa i ke kō a hoʻōlī i nā lima, e nalowale i ka ikaika a hilahila Hōʻeu ʻia ka nānā ʻana o ka ʻike maka, ka wikiwiki o ka puʻuwai a hiamoe mau i nā moe. Hoʻomaʻa pinepine pinepine nā mea maʻi me ka hypoglycemia i ka pōloli ʻole. Ua emi iki ka hihiʻo a ʻike ʻia ka naila. Ma ka hōʻeha koʻikoʻi o ka hypoglycemia, hoʻomohala ka mea maʻi i ka hoʻomanawanui a me ka hana lima ʻole o ka lolo. Inā ʻaʻole i hāʻawi ʻia ka kōkua i ka manawa, ke alakaʻi nei ka hypoglycemia i ka make o ka mea maʻi,

Nā hopena keu - nā pilikia haunaele i pili me ka nui o nā turgor kiko, retinopathy diabetic, peropheral neuropathy, ʻeha ma ka pūnaewele hōʻea.

Novomiks: ke aʻo no ka hoʻohana ʻana

Ma mua o ka hoʻohana ʻana i ka huahana, e hopu i kahi pahu kāwele a i ʻole ka waiho ʻia ʻana a lūlū. E nānā i ke kala o ka ipu - e pale pono i ka pale me ka keʻokeʻo. ʻO nā ʻōpili i hoʻopili ʻia i nā paia o ke pahu lāʻau ʻaʻole pono. Hoʻokahi wale ka hoʻohana ʻana ʻia me ka pono - inā e haʻalele ʻole i kēia kānāwai, a laila pilikia ʻoe i ka lilo.

Ma mua o ka hoʻohanaʻana, pono e nānā i nā loina a me nā hana mua.

• Mai hoʻohana i ka lāʻau lapaʻau inā ma mua o ia e waiho ʻia ana ma loko o ka pahu manuahi,
• Inā manaʻo ka mea maʻi i ka haʻahaʻa o ke kō, ua pale paʻa i ka lawelawe ʻana i ka lāʻau. E hoʻonui i ka glucose, lawa
• Eʻai i nā haʻalulu māmā (e like me ka ʻaila)

Mai poina e pili ana i ka mālama maʻamau i nā pae o ke kō. E hāhai i nā ʻōkuhi e pale i nā kūlana koʻikoʻi a me kahi hāʻule koʻikoʻi i ka glucose.

Ka kuʻikahi me nā lāʻau lapaʻau ʻē aʻe

Ke heluʻana i ka ʻai, e noʻonoʻo pono i kekahi mau lāʻau hiki ke hōʻeha i ka metabolism. Ke komo nei kēia mau lāʻau:

nā lāʻau lapaʻau e alakaʻi ai i kahi emi loa o ke kō, ʻoi.

• Okreotide
• MAO
• Kahiko,
• Anetiki
• Sulfonamides,
• ʻO nā huahana e loaʻa ka waiʻona.

Eia kekahi, ʻo kahi hui o nā lāʻau lapaʻau e kū mai i kahi e pono ai ka Novomix 30 FlexPen. Loaʻa kēia ʻāpana: nā huahelu thyroid, nā pā pono hoʻomalu, kālāzole, thiazides, HSC.

Ka hopena i ka hiki ke hoʻokele

ʻO ka hopena maʻamau e nānā ʻia i ka wā o ka mālama ʻana he hōʻemi ʻokoʻa i ka hilo i nā waiwai pōʻino. ʻO kekahi o nā hōʻailona o ka hypoglycemia he mea kuʻikahi ia o ka minamina, ma muli o ka mea e hiki ʻole i ka mea maʻi ke alo i kahi mīkini paʻakikī a hoʻokele paha kaʻa i ʻole me ka hoʻopilikia ʻole.

Ma hope o ka hoʻokele ʻana, hōʻoia ka ʻike ʻole i ka piʻi o ka nui o ka hoʻonui i ke kō. Inā ʻike ʻole ʻia nā hōʻailona o ka hypoglycemia, ʻaʻole pono ke hāpai i kahi kaʻa, e hiki ke hāʻule ka hilo i kēlā me kēia manawa.

ʻO nā hala a me ke hoʻoponopono ʻana

Ua kuhikuhi ʻia ʻo Novomix e like me monotherapy a i ʻole pū ai me nā lāʻau lapaʻau ʻē aʻe. Hoʻokomo ʻia ka dosis ma ke ʻano o kēlā me kēia a me nā ʻano o ka maʻi:

• Ma ka maʻi o ka lua, ʻo ka helu mua he 6 mau papa ma mua o ka pāʻina mua a me nā papa like ma mua o ka ʻaina. Me ka piʻi nui o ka insulin, ua hoʻoponopono ʻia ke ʻano i nā ʻāpana he 12,
• Inā hoʻololi ka mea maʻi i ka mālama ʻana me ka insulin biphasic i Novomix, ke ʻano mau ka dosage mua me ka regimen ma mua. Eia kekahi, ua hoʻololi ʻia ke ʻano inā pono. Ke hoʻoiho nei i ka mea maʻi i kahi lāʻau hou, koi ʻia ka nānā ʻana e ke kauka hele nei.
• Inā hoʻoikaika ʻia ka lāʻau lapaʻau, e kauoha ʻia ka mea maʻi i ʻelua pālua o ka lāʻau,
• Ke hoʻololi i ka waiū, e ana i kou kaila wikiwiki no nā lā 3 hope loa. Inā i loko o kēia manawa ua ʻike nui ʻia kahi kiʻekiʻe o ke kō, ʻaʻole i hoʻoponopono ʻia ke ʻano.

Hoʻoponopono ʻia ka nui o hoʻokahi ma kahi o hoʻokahi pule. Hiki iā ʻoe ke kamaʻilio me nā loiloi no ka hoʻoponopono ʻana o ka hoʻoponopono i nā ʻōlelo aʻo i hoʻopili ʻia i ka pā helu.

Pehea e hoʻokele ai i ka insulin

ʻO ka hui pū ʻana o kahi maʻi i koho ʻia a me kona hoʻopuka pololei ʻana i ke kino ke kumu nui o ka mālama ʻana i ka maʻi diabetes mellitus.

1. Ma mua o ka hoʻohana ʻana i ka hoʻonā, e hoʻopaʻa no ia i 1-2 mau hola ma kahi mahana o 15-20 tikeri. A laila e kaʻi i ka pahu a kū i ke aniani. Mālama i ka pahu kolo ma waena o kou mau pālapa, a hui pū i kou mau lima e like me ke kāʻili ʻana i kahi lāʻau a i ʻole kekahi mea cylindrical. E hana hou a i 15 mau manawa.
2. E neʻe mālie a kuʻi i ka pahu pahu kūwili a lūlū i ke kahe i ka pahu ma loko o ka pahu a i kekahi.
3. E hana i nā pae i 1 a me 2 a hiki i nā mea paʻa o ka pahu i nā ao a lilo i keʻokeʻo.
4. E hoʻopili mālie i ka momona subcutaneous. Mai kaha i nā ʻike o nā pahu i ka vein - e hoʻonui kēia i ka nui o ke kō koko.
5. A emi ma lalo o 12 PIECES o ka lāʻau lapaʻau i waiho ʻia i loko o ka ipu, e hoʻohana i kahi wai hou e hoʻohui hou i nā ʻano nui.

E hoʻomau i ka pihi hoʻomaka a hiki i ka maʻi ʻana o ke ʻano holoʻokoʻa ma lalo o ka ʻili. Inā ʻoe e hoʻohana i nā huahana 2 like ʻole, mai hoʻohui iā lākou i hoʻokahi pahu.

E lawe mau ʻoe i kahi ʻōpiopio pale me ʻoe inā he hiki ʻole i ka mea kahiko.

ʻO ke kōkua mua no ka overdose

ʻO kahi hōʻailona nui o ka overdose o Novomix he hypoglycemia koʻikoʻi. Hiki ke kōkua ʻia kahi maʻi maʻi i kēia ʻano i kekahi mau ʻano:

• Me kahi minamina o ke kō, e hāʻawi i ka mea maʻi i kekahi huahana e loaʻa i nā polokalamu māmā. Hoʻopili pū kekahi o ka confectionery: ʻaila, kīlaʻi, etc. ʻO nā huahana a me nā ʻoni ʻona i nā manawa āpau - pono ke hoʻonui i ka manaʻo o ke kō e hiki ai i nā manawa āpau.
• Hana ʻia ka hypoglycemia koʻikoʻi me ka hopena o ka momonaagon. Aia kēia lāʻau lapaʻau i ka nui o 0.5-1 mg. i hoʻopaʻa ʻia intramuscularly a iʻa subcutaneous momona paha,
• ʻO kekahi mea e hana ai i ka glucagon he Dextrose hopena. Ua hoʻokomo ʻia i nā hihia koʻikoʻi, i ka wā i loaʻa ai ka mea maʻi i ka glucagon, ʻaʻole ia e ʻike hou i ka lōʻihi ma mua o 10 mau minuke. Hoʻonohonoho ʻia ʻo Dextrose. Hiki i kahi mea hoʻomaʻamaʻa kūikawā a kauka paha ke hana i kēia.

I mea e hoka ai i ke kō, eʻai i nā meaʻai me nā mea momona a maʻalahi. Mai poina e pili ana i ka mālama ʻana - ʻai i nā ʻāpana liʻiliʻi i ʻole e lilo ai kahi kua hope.

ʻO nā inoa kalepa, ke kumukūʻai, nā kūlana mālama

Hele ka lāʻau lapaʻau i nā lāʻau lapaʻau ma lalo o nā inoa kālepa. Hoʻolālā lākou kēlā me kēia helu ma kahi kikoʻī a me ke koʻikoʻi o ka waiwai ikaika.

Ua hoʻololi iki ke kumukūʻai:

1. Novomiks FlexPen - 1500-1700 rubles,
2. Novomiks 30 Penfill - 1590 rubles,
3. Insulin Aspart - 600 mau rubles (no kahi pen-syringe).

Manaʻo ʻia ka lāʻau lapaʻau e mālama i kahi mahana ʻaʻole iʻoi aku ma kahi o 25 mau kiʻekiʻe ma kahi wahi pōʻeleʻele ʻole i hiki i nā keiki.

Inā ʻaʻole kūpono kēia huahana iā ʻoe a ʻaʻole i ʻae ʻia e ke kino ma muli o nā mea kōkua, manaʻo mākou e familiarize ʻoe iā ʻoe iho me nā mea hoʻohālike:

• Novomix 30 Penfill. ʻO kēia kahi māhele ʻelua o ka lāʻau aloha aspart a insulin. Hoʻohui kēia i nā hormones e hana no ka manawa pōkole a lōʻihi. Hoʻonui ia i ka hana o nā mea nui, hoʻonui i ka neʻe o ka glucose i ka pae o ka cellular a me kona hiki ke hoʻihoʻi ʻia e nā ʻili ʻē aʻe. Hoʻopilikia ia i ka palupalu, hoʻemi i ka hana glucose a hoʻokaʻawale i kona ʻano i ke koko. ʻAʻole like me ka Novomix maʻamau, pono ia ma kahi o 24 mau hola. Hoʻopili ke hoʻonohonoho o nā mea hana ikaika me ka insulin kūlohelohe, no laila he palekana ka hāmeʻa no ke kino. Me ka hoʻohana pono, ʻaʻole pono nā lāʻau lapaʻau i nā hopena kūpono ʻole. Contraindicated ma lalo o nā makahiki he 18, me hypoklycemia a me hypersensitivity,
• Novomix 30 FlexPen. Hoʻopilikia ia i ka hana o ka insulin a hoʻoulu i nā kaʻina hana i hana i loko o nā pū. ʻO ka lōʻihi o ka hana e pili ana i ka wahi o ka injection, ka hana kino, ka dosage a me nā mea ʻē aʻe. Ua kuhikuhi ʻia ka lāʻau lapaʻau no ka mālama ʻana i ke ʻano o ke ʻano type type 2 a me ke ʻano 2
• Novomix 50 FlexPen. Hoʻohālikelike kēia mea hana like me nā lāʻau lapaʻau ʻelua i hōʻike ʻia ma luna nei. Ka ʻokoʻa wale ka ʻokoʻa i ka manaʻo o ka mea hana. No kēia kumu, pono ʻoe e ʻimi mau i ke kauka ma mua o ka hoʻomaka ʻana i ka ʻoihana.

Ke koho nei i ka lāʻau kūpono, e noʻonoʻo e ʻaʻole wale i ke kumukūʻai, akā, nā mea nui hoʻi. Hoʻopili pū kēia me ke ʻano o ka insulin, nā ʻano pilikino o kou kino, ka hoʻomanawanui i nā mea a me nā maʻi pili.

ʻLoe a me ke kākele

Hoʻopuka no ka ʻākala subcutaneous. ʻO nā hoʻohālikelike he hypoglycemia, hypersensitivity.

E mālama ʻia ʻo Rosinsulin C i ka subcutaneously 1-2 mau manawa i ka lā, ma kahi hapalua hola ma mua o ka ʻai ʻana. I kēlā me kēia manawa, pono e hoʻololi ʻia ka pūnaewele injection. I kekahi mau hihia, hiki i ka endocrinologist ke kuhikuhi i ka maʻi maʻi intramuscular o ka lāʻau.

E makaʻala! Hoʻokomo ʻia ka ʻae ʻana o ka insulin o ka lōʻihi o ka wā! I kēlā me kēia hihia pākahi, koho ke kauka i kēlā me kēiaʻano i hiki ke kau ʻia ma luna o nā ʻano o ke ʻano o ka maʻi a me ka ʻike o ka honi i loko o ke koko a me ka ʻai.

ʻO ka maʻa maʻamau ka 8-24 IU, ka mea i mālama ʻia i ka manawa 1 i kēlā me kēia lā, no kēia hiki iā ʻoe ke hoʻohana i ka syringes insulin me kahi lāʻau e hoʻoneʻe ʻia ana. ka uluʻana - hoʻonui i 24 IU i kēlā me kēia lā a ʻoi paha.

Inā he keu ka lā o ka lāʻau lapaʻau ma mua o 0.6 IU / kg, e lawelawe ʻia ana 2 mau manawa i kēlā lā i nā wahi like ʻole. Inā mālama ʻia ka lāʻau lapaʻau ma loko o kahi nui o 100 IU i kēlā me kēia lā a oi paha, pono e mālama ʻia ka mea maʻi i ka haukapila. Pono ka loli o kekahi insulin i kahi ʻē aʻe ma lalo o ka makaʻi pono ʻana o nā kauka.

ʻO ka lāʻau lapaʻau e pili ana i nā insulins medium-duration, kahi i kuhikuhi ʻia:

1. e hōʻemi i ka glucose koko
2. e hoʻonui i ke kao o ka glucose e nā kiko,
3. e hoʻolōʻihi i ka glycogenogenesis a me lipogenesis,
4. e hoʻemi i ka paila o ka neʻe ʻana o ka glucose e ka ate,
5. no ke kāpili protein.

• angioedema,
• ʻaʻano pōkole
• urticaria
• emi i ke koko,
• fiva.

1. hoʻohui ʻoluʻolu,
2. a me ka ili o ka ʻili,
3. pololi
4. puʻuwai puʻuwai
5. hopohopo
6. haehae
7. hoihoi
8. hāpau
9. paresthesia i ka waha,
10. hiamoe
11. hopohopo kaumaha
12. ʻano e like me ka hana
13. huhū
14. maopopo ole o na neʻe
15. makaʻu
16. ka hoʻopuka ʻana a me ka hoʻōhohewa ʻana,
17. ʻōpala
18. lie kanikela.

Inā poino ʻoe i kahi maʻi kau, haahaa liʻiliʻi, e kūpaʻa ʻole ma ke kua o ke ʻano a i ʻole ka maʻi, a inā ʻaʻole ʻoe e hahai i ka ʻai, a laila e hoʻomohala ʻoe i ka maʻi diabetes a me ka hyperglycemia:

• hoʻemi i ka momona
• makewai
• hiamoe
• helehelena o ka maka,
• mea wiwoʻole i kahi coma,
• ka lawaiʻa ʻana o ka ʻike manuahi ma ka hoʻomaka ʻana o ka ʻoihana.

Ma mua o ka hōʻiliʻili ʻana i ka lāʻau lapaʻau mai ka hue, e maopopo i ka ʻoliʻoli ʻia. Inā ʻike ʻia ka palupalu a i ʻole kuhi paha i ka mākaukau, a laila ʻaʻole hiki ke hoʻohana.

Pono i ka mahana o ka hopena no ka hoʻokele kūpono i ka mahana o ka lumi.

He mea nui ia: inā ua maʻi ka maʻi maʻi o ka maʻi ʻeha, nā maʻi thyroid, hypopituitarism, maʻi ʻo Addison, kahi mākaʻikaʻi papaha a me ke kanaka, ʻoi aku ka 65 mau makahiki o ka maʻi, he kūpono ka hoʻoponopono ʻana i ka insulin.

Hiki i nā kumu o hypoglycemia ke:

1. Ka manawa o ka lāʻau.
2. Ke keu.
3. Ke ʻoki nei i ka ʻaina.
4. ʻO nā maʻi e hōʻemi ai i ka pono o ka lāʻau.
5. He luaʻi, nā maʻi ʻeha.
6. Hypofunction o ka adrenal cortex.
7. Ke kaumaha kino.
8. E hoʻololi i ka wahi ʻoi.
9. Hoʻopili pū me nā lāʻau ʻē aʻe.

Ke hoʻoneʻe nei i ka maʻi mai ka maʻi holoholona i ka insulin kanaka, hiki i ka emi ʻana o ke kōpaʻa koko kōpau.

ʻO ka wehewehe ʻana i ka hana a ka lāʻau Rosinsulin P

ʻO Rosinsulin P e pili ana i nā lāʻau lapaʻau me ka hopena hypoglycemic pōkole. ʻO ka hui pū me ka mea nāna o ka membrane waho, ka hoʻonā ka hoʻonā ʻana. ʻO kēia paʻakikī:

• hoʻonui i ke keaka o ka monophosphate cyclic i loko o nā ate a me nā momona momona,
• Hoʻokomo i nā kaʻina hana intracellular (pyruvate kinases, hexokinases, synthases glycogen a me nā mea ʻē aʻe).

Hōʻike ka emi ʻana o ke kō kōʻai koko ma muli o:

1. hoʻonui i ka lawe i ke kaʻa,
2. stimulasi of glycogenogenesis, lipogenesis,
3. hoʻonani protein
4. hoʻonui i ke kō ʻana o ka lāʻau lapaʻau ma o nā ʻili,
5. hōʻemi i ka wā o ka haʻaluluʻana o ka glycogen (ma muli o kahi kahe o ka hana o ka glucose e ka pepona).

Ma hope o ka hoʻolālā subutaneus, ua loaʻa ka hopena o ka lāʻau i ka 20-30 mau minuke.Loaʻa ka ʻike kiʻekiʻe loa i ke koko ma hope o nā hola 1-3, a me ka hoʻomau i ka hana ʻoi aku ka hilinaʻi i ka wahi a me ke ʻano o ka hoʻokele ʻana, ʻona a me nā hiʻohiʻona pilikino o ka mea maʻi.

Nā hōʻailona no ka hoʻohana ʻana

Hoʻohana ʻia ka Rosinsulin P i kēia mau helu:

1. ʻO ka maʻi mellitus mika1 a me 2.
2. ʻO ka pale kuʻuna i nā lāʻau lapaʻau hypoglycemic waha.
3. Hoʻohui hui
4. Ketoacidotic a me ka hyperosmolar coma.
5. Maʻi molaʻi.
6. Hoʻopilikia ka maʻi maʻi i ka wā hāpai.

No ka mea hoʻohana:

• i ka wā hānau keiki ʻana, nā hōʻeha, ke kau wā hōʻemi e hiki mai ana.
• ma mua o ka hoʻololi ʻana i nā injections me ka hoʻomākaukau ʻana o ka insulin i ka lōʻihi,
• me nā maʻi māhu,
• me nā maʻi i hele pū ʻia e ke kuni nui.

Nā ʻōmole a me ka helu

ʻO nā hoʻohālikelike he hypoglycemia, hypersensitivity.

ʻO ke ala o ka hoʻokele ʻana o ka lāʻau a me ka kūmai i kēlā me kēia hihia i hoʻoholo ʻia pākahi. ʻO ke kumu no ka hoʻoholo ʻana i ka ʻaʻeʻa ka pau loa o ke kō i loko o ke kahe koko ma mua a ma hope o ka ʻai, ka papa o ka maʻi a me ka kiʻekiʻe o ka glucosuria.

Kuhi ʻia ka Rosinsulin P no ka ʻākala subcutaneous, intravenous a intramuscular. Hana ʻia nā inātai 15-30 mau minuke ma mua o ka pāʻina. ʻO ka pinepine, ʻo ka hoʻonā o ka hoʻokele a me ka subcutaneously.

i loko o nā hana hoʻokuʻi, mālama ʻia ka ketoacidosis a me ka coma, ka hoʻōla ʻia ʻana o rosinsulin P i ka intraus a me intramuscularly, no ka mea he mea pono ke ʻike i ka hoʻopili ʻana i ka insulin me ka pololei.

Me monotherapy, ʻo ka helu o nā inikina i kēlā me kēia lā he 3 mau manawa. Inā pono, hiki ke hoʻonui ʻia iā lākou i nā manawa 5-6. No ka paleʻana i ka hoʻomohala ʻana o nā lipodystrophy, ka momona o ka momona hypertrophy, atrophy, pono ia e hoʻololi i ka pūnaewele injection i kēlā me kēia manawa.

• angioedema,
• ʻaʻano pōkole
• emi i ke koko,
• urticaria
• fiva.

1. hoʻohui ʻoluʻolu,
2. tachycardia
3. hoihoi
4. hiamoe
5. a me ka ili o ka ʻili,
6. pololi
7. hopohopo o ke kaumaha
8. haehae
9. hāpau
10. paresthesia i ka waha,
11. ka hoʻopuka ʻana a me ka hoʻōhohewa ʻana,
12. maopopo ole o na neʻe
13. manaʻo ʻino
14. ʻano ʻē
15. huhū
16. ʻoluʻolu
17. ʻōpala
18. lie kanikela.

E kūʻē i ke kua mua o nā maʻi a i ʻole ke kuni, a me ka inikia palia, he haʻahaʻa haʻahaʻa, a inā ʻaʻole i hahai ʻia ka mea ʻai, hiki i ka mea maʻi ke hoʻomohala i ka acidosis maʻi maʻi a me ka hyperglycemia:

• lilo ka momona
• makewai
• hiamoe
• ka ʻōpū o ka maka
• mea wiwoʻole i kahi coma,
• ka lawaiʻa ʻana o ka ʻike manuahi ma ka hoʻomaka ʻana o ka ʻoihana.

Ma mua o ka ʻohi ʻana i ka rosinsulin C mai kahi hue, pono ʻoe e ʻike i ka ʻae ʻia ka ʻōlelo. Inā ʻike ʻia ka luhi a i nā kūpuna paha i ka insulin, ʻaʻole hiki ke hoʻohana. Pono ka mahana o ke kōkohu ma ka mahana o ka lumi.

E makaʻala! Inā loaʻa i ka mea maʻi ka maʻi maʻi, nā huehue o nā kelima thymus, hypopituitarism, maʻi a Addison, kahi mākaʻikaʻi renal, a me nā poʻe no ka 65 makahiki o kona mau makahiki, e koi ʻia ka hoʻoponopono ʻana i ka insulin.

Hiki i ka hopena o ka hypoglycemia ke:

1. Hoʻololi i ka lāʻau.
2. ʻĀnō nui.
3. Ke ʻoki nei i ka ʻaina.
4. ʻO nā maʻi e hōʻemi ai i ka pono o ka lāʻau.
5. Auā, ʻeha.
6. ʻAʻohe hana cortex hana.
7. Hoʻohana kino.
8. Hoʻololi ka wahi o ka injection.
9. Hoʻopili me nā lāʻau lapaʻau ʻē aʻe.

Ke hoʻoneʻe nei i ka maʻi mai ka maʻi holoholona i ka insulin kanaka, hiki i ke kaila o ke kō o ke kō.

Nā kuʻuna o NovoMix

ʻAʻohe ʻano lāʻau ʻē aʻe me ka like pū me ka like me NovoMix 30 (aspart + aspart protamine), ʻo ia hoʻi, kahi analogue piha. ʻO nā insulins biphasic ʻē aʻe, analog a me ke kanaka, hiki ke hoʻololi iā ia:

Humalog Mix 25

Humalog Mix 50

E hoʻomanaʻo o ke koho ʻana i kahi lāʻau lapaʻau a me kāna dosage ka mea maikaʻi loa me kahi loea.

E kū e aʻo! Manaʻo paha ʻoe i ka hoʻokele o ke ola i nā pōpoki a me ka insulin ke ala wale nō e mālama ai i ke kō i lalo o ka mālama ʻana? ʻAʻoleʻoiaʻiʻo! Hiki iā ʻoe ke hōʻoia i kēia ʻo ʻoe iho ma ka hoʻomaka ʻana e hoʻohana ... heluhelu hou aku >>

Nā hōʻailona a me nā contraindications

Hoʻohana ʻia ka Bypasic insulin Aspart (kahi mea kikoʻī o Flexpen) i ka mālama ʻana i ka ʻano type type 1 a me ke ʻano type type 2 mellitus inā ua hala ia i ka insulin-depend phase.

ʻAʻole hoʻohana ʻia ka lāʻau me ka intolerance pilikino i kāna mau ʻāpana a me ka hoʻonui ʻana iā lākou. ʻAʻole i noiʻi ʻia ka noi ʻana i nā keiki i lalo o ke 6 mau makahiki o laila, no laila, ʻaʻole pono ke noi ʻia e hoʻohana i kekahi o ko lākou mau ʻelele i kēia makahiki.

Hoʻohana ʻia ka hoʻohana ʻana i ka hāpai ʻana. ʻAʻole i hoʻokō ʻia nā hoʻokolohua piha. Pili ka like me ka FlexPen a me Novorapid Penfill. Akā i loko o nā haʻawina ʻelua o ka lāʻau Novorapid Penfill ma nā wahine hāpai, ʻaʻohe data i loaʻa i ka hopena maikaʻi ʻole o ka waiwai ma ka hāpai ʻana a me ke ʻano o ka pēpē.

Hiki i nā makuahine kahu maʻi ke hoʻohana i ka insulin i ka nui o ka pono, ʻaʻole ia e pili i ke keiki. Pono paha e hoʻoponopono i ka ʻōpū no ka makuahine.

Hōʻike ka hoʻonāukiuki i ke ʻano o ka hana nui a ka hormone. ʻO ke kūlana o ka hypoglycemia i ka wā e hoʻohana ai i ka lāʻau biphasic e ulu pinepine i ka hanana pinepine ma mua o ka regimen dosage maʻamau.

Hōʻike ʻia kēia ʻanoʻano ʻino ʻekena:

• Urticaria, rashes ʻili, līkuhi - hoʻoiho kūloko.
• ʻO ka neuropathy peripheral.
• ʻO nā maʻi hōʻemi (ʻoi aku ka hoʻomaka i ka hopena), retinopathy.
• Lipodystrophy ma ka wahi ʻōlelo.
• Nā kūloko o ke kūloko ma nā wahi o ka ʻoihana.

Ke lawe nei i kekahi mau lāʻau lapaʻau me ka piʻi ʻana o ka hopena Aspart a me ka hiki ke hoʻomohala ʻana i ka hypoglycemia:

• Nā maʻi hoʻohālikelike.
• Nā mea hoʻonani o MAO, ACE.
• Hoʻopau.
• Nā diuretaha Thiazide.
• Heparin.

Hiki i ka alakino ke hoʻoikaika a hoʻonāwaliwali i ka hopena o ka mālama ʻana i ka hormonal.

Kahi papaʻaila

Hoʻonohonoho ʻia ka Bovine, puaʻa, a me ka insulin o ka kanaka, e hilinaʻi ana i ko lākou kumu. ʻAʻole hoʻohana pinepine ʻia nā ʻano 2 mua i kēia mau lā. ʻO ke kolu, ka mea i loaʻa i ka hoʻohana ʻana i ka ʻenehana loea genetic, ʻo ia ke koho mua no ka ʻomo ʻana i ka insulin.

Wahi a ka lōʻihi o ke hana, aia nā:

• IUD - nā mea hana hewa pōkole
• ICD - hana insulins pōkole
• ISD - nā lāʻau lapaʻau o ka lōʻihi lōʻihi o ka hana,
• IDD - hana lōʻihi
• insulins i hoʻohui mai (loaʻa i ka insulin o nā ʻano like ʻole o ka hana).

ʻO ke kumumanaʻo o ka hana o ka insulin a me nā hopena

ʻO ka insulin he hormone polypeptide. ʻO ka maʻamau, aia i loko o nā β-cell o ka pancreas i mua o kāna mea kōkua - proinsulin, kahi e hoʻopili ai ka C-peptide a laila hana ʻia ka insulin. Me ka hoʻonui nui o ka glucose o ke koko, me ka hoʻonāukiuki ʻana o ka nerve vagus, me ke kaomi ʻana o kekahi mau kumu ʻē aʻe, ua hana ʻia nā kaʻina o ka hoʻokuʻu ʻana o ka insulin.

Ma o ka nakinaki i ka mea nāna e hopu i ka membrane o ka cell target, hoʻomaka ka hana a me ka hoʻomaʻamaʻa ʻana i nā hopena physiological:

• ka hoʻemi ʻana o ke kō o ke koko (e hoʻoulu i ka kaomi ʻana o ka glucose e nā kopa, kaohi ʻana i nā ʻōnaehana o kāna hana i loko o ke kino mai nā mea ʻē aʻe).
• hoʻōla i ka synthly glycogen,
• hoʻohiolo i ka hoʻokumu ʻana o nā kino ketone,
• pale i ka ho okumu ana o ka glucose mai nā pūhui nonohina,
• neʻe i ka hana o kahi lipoproteins haʻahaʻa loa a me ka triglycerides,
• hoʻōla i ka synthesis o nā protein,
• hoʻonāukiuki i ka hana o glycogen, i mea e hana ai i ka mālama o ke kino o ke kino,
• pale i ka wāwahi o nā momona, hoʻihoʻi i ka hana o nā aikiki momona mai nā pika.

Pehea ka hana ʻana o ka insulin i waho i ke kino

ʻO ke ala nui o ka hoʻomaluʻana o ka insulin he subcutaneous, akā i kahi kūlana kūlea, i mea e hoʻokō ai i ka hopena wikiwiki, hiki ke hiki ke hōʻemi ʻia ka lāʻau lapaʻau i loko o kahi uaua a pakanā paha paha.

ʻO ka helu o ka haʻawina o ka hormone mai ka wahi o ka hoʻokūkū kūloko i hilinaʻi ʻia i ka pūnaewele injection, ka ʻano a me ke ʻano o ka lāʻau lapaʻau, ka maikaʻi o ke kahe ana o ke koko a me nā hana hoʻoikaika i loko o ka wahi o ka injection, me ka ʻae ʻana me ke ʻano o ka injection.

• Hoʻokomo ʻia nā insulins Ultra-pōkole e wikiwiki a i loa i loko o 10-20 mau minuke ma hope o ke kēkē ʻana ke kumu i ka emi ʻana o ke kahe o ke koko. ʻOi lākou ka maikaʻi ma hope o 30-180 mau minuke (pili i ka lāʻau lapaʻau). Kūpono no nā hola 3-5.
• ʻO ka hopena o nā insulins pōkole e hana i nā minuke 30-45 ma hope o ko lākou hoʻoponopono. ʻO ka pihi o ka hana mai ka 1 a 4 mau hola, ʻo kona lōʻihi he 5-8 mau hola.
• Hoʻomoe mālie ka insulin medium-lōʻihi mai ka pūnaewele injection a hāʻawi i kahi hōʻemi o ke kō koko koko wale nō he 1-2 mau hola ma hope o ka ʻike o ka subcutaneous. Ua hoʻopaʻa ʻia ka hopena kiʻekiʻe ma loko o nā hola 4-12, ʻo ka lōʻihi o ke kūleʻa he 0.5-1 mau lā.
• Hoʻomaka ka hana lōʻihi o ka insulin e hana 1-6 mau hola ma hope o ka hoʻokele subutaneus, hōʻemi i ke kō i ke kai - - ʻaʻole i hōʻike ʻia ke kihi o ka hana i ka hapa nui o kēia mau lāʻau, ua holo a hiki i 24 mau hola, pono ia e hoʻolilo i kahi lāʻau lapaʻau hoʻokahi wale nō i ka manawa 1 ka lā.

Hoʻopilikia ka "ʻano" ka ʻona i loko o ke kino ma hope o ka hoʻokele ʻana e:

• ʻoi aku ka nui o ka lāʻau (ʻo ke kiʻekiʻe o ia, ʻoi aku ka paluhalelo i ka lāʻau a e lōʻihi ka hana ʻana)
• wahi i ke kino o ke kino i hana ʻia ai ka maʻi (ma ka ʻōpū, he ʻokoʻa loa ke komo ʻana, ma ka ʻūhā ʻemi, i loko o nā ʻāpana o ka ʻūhā a emi mai hoʻi).
• ala o ke alakaʻi (me ka subcutaneous injection, hopu ʻia ka lāʻau lapaʻu me ka lohi ma mua o ka hiki ʻana i ka maʻa, akā ʻoi aku ka lōʻihi),
• ka ʻōpū o ka mahele ma ka wahi o ka hoʻokele (inā i hoʻonui ʻia ʻo ia, e hoʻonui ka nui o ke kō)
• lipomas a i ʻole lipodystrophy o nā lau (e pili ana i ka mea, e heluhelu i lalo)
• ʻoi a hoʻolōʻihi paha ka hana ʻana (ʻo ke kaʻina o nā ʻōkuhi).

Ma kekahi mau'āina, ke noiʻi nei nā poʻe loea i nā hoʻomākaukau no ka insulin me nā ala e hiki ai ke hoʻokele no ka mea maʻi. No laila, i ka US, aia ka insulin no ka hoʻokele e ka inhalation. Hoʻomaka ia e hana ma hope o 30 mau minuke (e pili ana iā IUD) ka mea ma kahi o 2 mau hola, ʻoi aku ka lōʻihi o 8 mau hola (kahi like me ka ICD).

Composial NovoMix 30 FlexPen

ʻO ka hoʻokuʻuʻana i ka s / c kaila keʻokeʻo, ʻokoʻa homogeneous (ʻaʻohe kīpili paha, ʻike ʻia ka papalaki paha i loko o ke ʻano hoʻohālike), ke kū nei, e hoʻokaʻawale, hana i kahi kūleʻa keʻokeʻo a i ʻole a i ʻole nā ​​kala i ʻulaʻula ʻole, he hoʻopiʻi homogeneous pono e hana me ka puʻu ʻana me ka makaʻala.

Nā mea kūʻokoʻa: glycerol, phenol, metacresol, zinc chloride, sodium chloride, sodium hydrogen phosphate dihydrate, protamine sulfate, sodium hydroxide, hydrochloric acid, wai d / a.

* 1 hui e pili ana i 35 mcg o ka ʻōpū insulin anhydrous.

3 ml - mau pahu kāwili (1) - nui-wai hoʻonaninani no nā syringe penikala no nā inikini hou (5) - nā pā o ka pahu paʻi.

ʻO nā mea hoʻohālikelike insulin inumaleka lōʻihi me ka hoʻomaka ʻana o ka hana

Kahi i ka analogue kanaka o ka lōʻihi lōʻihi me ka hoʻomaka wikiwiki o ka hana.

ʻO NovoMix ® 30 FlexPen ® kahi hana hoʻokaʻawale i ke aniani i ka hopena o ka insulin aspart (30% analog insulin hana pōkole) a me nā crystals o ka ʻatikala protart protamine (70% medium-acting insulin analog).

Insart aspart i loaʻa e ka recombinant DNA biotechnology me ka hoʻohana ʻana i kahi mākaʻikaʻi o Saccharomyces cerevisiae.

Hoʻopili pū kekahi me kahi receptor kūikawā ma ka membone cytoplasmic o waho o nā pūpū a hana i kahi mea hoʻohui insulin-receptor e hoʻoikaika i nā hanana intracellular, e komo synthesis o kekahi o nā kīʻaha koʻikoʻi (hexokinase, pyruvate kinase, glycogen synthetase). Hoʻohui ka hopena hypoglycemic me ka nui o ka holo intracellular a me ka hoʻonui ʻana i ka hoʻoliʻi o ka glucose ma o nā kiko, hoʻoulu ʻana i ka lipogenesis, glycogenogenesis, a me kahi ka emi o ka hōʻaia o ka hana glucose e ka ʻāʻī.

Ke hoʻohālikelike ʻia i ka kōloli ʻana o ka inika manuahi, a me ka laʻana o ka insulin (kahi hana wikiwiki o ka insulin kanaka) e hana wikiwiki, no laila e hiki koke ke lawelawe ʻia ma mua o nā meaʻai (mai ka 0 a 10 mau minuke ma mua o ka ʻai). ʻO ka ʻikepili o ka crystalline (70%) ka insulin aspart protamine (kahi mea hoʻomohala i ka insulin o ke kanaka o ka lōʻihi o ka lōʻihi), ʻo ia ka hopena o ka like me ka hana o ka insulin isophane kanaka.

Ma hope o ke kaila s / c o ka lāʻau NovoMix ® 30 FlexPen ®, ulu ka hopena ma hope o 10-20 mau minuke. Loaʻa ka hopena kiʻekiʻe loa i nā hola 1-4 ma hope o ke kūkaʻi. Loaʻa ka lōʻihi o ka lāʻau lapaʻau i 24 mau hola.

I ka manawa e hoʻohana ʻia ai i ka poʻe maʻi me ka diabetes type type 1 a me ka type 2, ʻo NovoMix ® 30 FlexPen ® kahi hopena like i ka pae o ka hemoglobin glycated e like me ka biphasic insulin insulin 30.

Ua hōʻike ʻia kahi haukao ʻekolu mau mahina e pili ana i nā maʻi me ka maʻi type type 1 a me 2 ke hōʻike nei ʻo NovoMix® 30 FlexPen® ka hopena like i ka hemoglobin glycated e like me ka biphasic insulin insulin 30.

I loko o kahi haʻawina hōʻike pili e pili ana i nā maʻi me ka diabetes mellitus type 2 (n = 341), ua hoʻokaʻawale ka poʻe maʻi i nā hui lapaʻau wale nō me NovoMix ® 30 FlexPen ®, NovoMix ® 30 FlexPen ® i hui pū me ka metformin a me ka metformin i hui pū ʻia me kahi deronative sulfonylurea. Ka hoʻohālikelike ʻana o ka mākaukau mua o HbA 1c ma hope o 16 mau pule o ka mālama ʻana i nā mea maʻi e loaʻa ana iā NovoMix ® 30 FlexPen ® i hui pū me ka metformin a i nā mea maʻi e loaʻa ana i ka metformin i hui pū me kahi derivative sulfonylurea. Ma kēia noiʻi ʻana, he 57% nā mea maʻi i loaʻa i kahi basal HbA 1c pae kiʻekiʻe ma mua o 9%; i kēia mau maʻi, ʻo NovoMix ® 30 FlexPen ® i hui pū me ka metformin i hopena i ka emi ʻana o ka HbA 1c ma mua o nā mea maʻi i mālama pū me ka metformin i hui pū ʻia me kahi derivative sulfonylurea.

Ma kekahi noiʻi hou, nā mea maʻi me ka diabetes mellitus type 2 ʻaʻole hiki ke mālama pono ʻia e ka lawe ʻana i nā lāʻau lapaʻau hypoglycemic waha i loko o kēia mau pūʻulu: NovoMix ® 30 FlexPen® 2 mau manawa / lā (117 nā mea maʻi) a me ka haukapila insulin 1 manawa / lā (116) maʻi). Ma hope o 28 mau pule o ka lāʻau lapaʻau, ʻo ka hoʻololi nui ʻana o ka HbA 1c i ka pūʻulu NovoMix ® 30 FlexPen ® ʻo 2.8% (mau waiwai kumu mua o 9.7%). ʻO 66% a me 42% o nā maʻi e hoʻohana ana i ka NovoMix ® 30 FlexPen ®, i ka hopena o ka noiʻi, ua loaʻa nā waihona o HbA 1c ma lalo o 7% a me 6,5%, kekahi. ʻO ka kumu ʻaila plasma wikiwiki e piʻi ana e 7 mmol / L (mai 14 mmol / L i ka hoʻomaka ʻana o ke noi ʻana i 7.1 mmol / L).

Ua mālama ʻia kahi haʻawina hauoli 16-wiki i nā keiki a me nā ʻōpio i hoʻohālikelike i ka glucose koko ma hope o ka ʻai ʻana me NovoMix ® 30 FlexPen® (ma mua o ka ʻai), nā manuahi a me nā insulin o ka biphasic kanaka 30 (ma mua o ka ʻai) a me ka insulin-isophan ( lawelawe ʻia ma mua o ka wā hiamoe. ʻO ka noiʻi ʻana e komo pū ana i nā maʻi he 167 o 10 a 18 paha makahiki. ʻO nā kumukūʻai o ka HbA 1c i nā pūʻulu ʻelua e noho kokoke ana i nā kumu mua i loko o ke aʻo ʻana. Eia nō hoʻi, i ka wā e hoʻohana ai iā NovoMix ® 30 FlexPen ® a i ole biphasic human insulin 30, ʻaʻohe ʻokoʻa o ka ʻuhuna o ka hypoglycemia. Ua mālama ʻia kahi ʻano cross-sectional ʻelua ma kahi heluna o nā mea maʻi ma waena o 6 a 12 mau makahiki (ka nui o nā maʻi 54, he 12 mau pule no kēlā me kēia ʻano lapaʻau).ʻO ka ulu ʻana o hypoglycemia a me ka piʻi nui o ka glucose ma hope o ka ʻai ʻana i ka hui e hoʻohana ana i ka NovoMix ® 30 FlexPen ® i hoʻohālikelike ʻia i nā waiwai i loko o ka hui e hoʻohana ana i nā insulin biphasic kanaka 30. ʻO nā kumu HbA 1c ma ka hope o ke aʻoʻana i ka pūʻulu e hoʻohana ana i ka insulin biphasic kanaka 30 ua haʻahaʻa loa ia i ka hui e hoʻohana nei iā NovoMix ® 30 FlexPen ®.

In insulin aspart, the substitution of proline amino acid at position B28 for aspartic acid hoʻemi i ka makemake o nā molekala e hana i ka hexamers i ka soluble NovoMix ® 30 FlexPen ® hapa, ʻike ʻia i ka soluble insulin kanaka. I kēia mea, ʻike ʻia ka insulin aspart (30%) mai ka momona o ka subcutaneous ma mua o ka soluble insulin e waiho ana i loko o ka insulin o nā biphasic. ʻO ka Insulin aspart protamine (70%), e like me ka isofan insulin o ke kanaka, e lana lōʻihi aku.

Ke hoʻohana nei ʻo NovoMix ® 30 FlexPen ® C max insulin i ka serum ma ka awelika 50% kiʻekiʻe ma mua o ka hoʻohana ʻana i ka inika manu ʻelua ʻelua manawa, ʻoiai ka manawa e hiki ai iā C max ma ka awelika 2 mau manawa ma mua. Ke hoʻolako ʻia ka lāʻau lapaʻau i nā mea hana olakino olakino ma kahi o 0.2 U / kg koʻikoʻi kino kino, ʻo ka nui C C ka nui 140 ± 32 pmol / L a ua loaʻa ma hope o 60 mau minuke.

I nā maʻi me ka diabetes type mellitus, ua loaʻa ka C max ma hope o ka mau minuke 95 a mālama ʻia ma kahi pae kiʻekiʻe ma mua o 0 no ka liʻiliʻi he 14 mau hola ma hope o ke kaʻina sc.

E hoʻi i ka hoʻoliʻi o ka serum insulin i kona pae mua ma hope o nā hola 15-18 ma hope o ka huikau sc.

Ka awelika T 1/2, e hōʻike ana i ka helu o ke kao o ka hapa protamine-bound, ʻo 8-9 mau hola

ʻO ka pharmacokinetics i nā hihia lapaʻau kūikawā

ʻO nā huahana pharmacokinetic o NovoMix ® 30 FlexPen ® i nā keiki a me nā ʻōpio ʻaʻole i aʻo ʻia nā haʻawina. Eia nō naʻe, ua aʻo ʻia ka lāʻau lapaʻau me ka pharmacodynamic waiwai o ka soluble insulin aspart i loko o nā keiki (6 a 12 mau makahiki) a me nā ʻōpio (13 a 17 mau makahiki) me ka maʻi diabetes type 1. I ka hoʻomanawanui o nā hui ʻelua, ua hōʻike ʻia ka likeʻana o ka insulin a me nā māka wikiwiki a me nā helu T max e like nō me ka poʻe i pākeke. Eia nō naʻe, ʻokoʻa nā mea nui a ka C nui i nā hui ʻelua ʻelua, e hōʻike ana i ke ʻano o nā koho kanaka i nā ʻikepili o ka insulin aspart.

I nā mea maʻi kahiko, a me nā mea maʻi me nā maʻi lēwa ʻole a i ʻole ka hana maoli, ʻaʻole i aʻo ʻia nā pharmacokinetics o NovoMix ® 30 FlexPen ®.

ʻO ka ʻikepili palekana preclinical

I loko o nā hōʻike vitro, kahi i hoʻopili ʻia me nā hāmeʻe a me nā ʻĀina a me IGF-1 a me nā hopena e ulu ana i ka ulu ʻana o ka cell, ua hōʻike ʻia ka like o nā hiʻohiʻona o ka aspart insulin i ka like me ka insulin o ke kanaka. Eia kekahi, ua ʻike ʻia e hoʻopaʻa ʻia ka aspart i ka insulin receptor i kahi ʻano hoʻohālike e like me ka insulin kanaka. I ke aʻo ʻana o ka maʻi (1 malama) a me nā maʻi ʻoʻaola (12 mau mahina), ʻaʻole i loaʻa ka ʻike i ka ʻike ʻana i nā waiwai ʻona nui i loko o ka maʻi aspart insulin.