Lisinopril (10 mg, Himfarm AO) Lisinopril

5 mg, 10 mg a me nā papa he 20

Aia ma ka papa papa

mea waiwai - lisinopril dihydrate 5.5 mg, 11.0 mg a 22.0 mg

(e like me ka lisinopril 5.0 mg, 10.0 mg a i ka 20,0 mg)

nā mea hoʻowalewale: lactose monohydrate, microcrystalline cellulose, sodium starch glycolate, calcium stearate.

Ke keʻokeʻo nei nā papa papaʻa i ka ʻalani poli-cylindrical i loko o ke ʻano, ma kekahi ʻaoʻao o ka papa i he chamfer, ma kēlā me kēia - kahi chamfer a me kahi hōʻailona ʻoihana ma ke ʻano o kahi kea (no nā dosages a 5 a 20 mg).

Ke keʻokeʻo nei nā papa papaʻa i ka ʻalani poli-cylindrical i ka ʻaoʻao, ma kekahi ʻaoʻao o ka papa i ka chamfer a me ka hopena, ma ka ʻaoʻao - kahi chamfer a me nā hui ʻoihana ma ke ʻano o kahi kūpaʻa (no ka laʻana o 10 mg).

ʻĀpana Pharmacotherapeutic

ʻO nā hopena hōʻeha e pili ana i ka ʻōnaehana renin-angiotensin. ʻO Angiotensin-hoʻohuli i ka enzyme (ACF) inhibitors. Lisinopril.

Koho ATX C09AA03

Pnā mea ulu lima

Lapaʻau lāʻau

ʻAʻole ʻai i ka ʻai i ka hoʻopili ʻana o ka lāʻau lapaʻau. Loaʻa ka lōʻihi loa o ka plasma koko i kahi mau hola 6 ma hope o ka lawelawe waha o lisinopril. ʻO Bioavailability ʻo 29%. Me ka ʻokoʻa o ka hui ʻana me ka angiotensin-hoʻohuli i ka enzyme, ʻaʻole hiki ke komo ka pilina me nā protein plasma ʻē aʻe. ʻAʻole ia i hoʻohuli ʻia, hoʻopi piha ʻia e nā keiki i loli ʻole. ʻO ka hapalua-ola kahi 12.6 hola. Hiki ʻo Lisinopril i ke kālai placental.

Lapaʻau lāʻau

No Lisinopril ka hui o ka angiotensin-hoʻololi lohi ʻana i ka enzyme inhibitors. Ke alakaʻi nei i ka ACF i kahi hōʻemi o ka neʻe ʻana o ka angiotensin II (me kahi hopena vasoconstrictor) a me kahi laʻana i kahi huna o ka aldosterone. Linesopril pū kekahi i ka wāwahi o ka bradykinin, kahi pā peptide vasodepressor. A ʻo kahi hopena, ke hoʻemi nei ia i ke kahe o ke koko, i ke kūpaʻa o ka vascular peripheral, pre- a and afterload ma ka naʻau, hoʻonui i ka nui o ka minuke, ka hopena cardiac, hoʻonui i ka hoʻolilo i myocardial e hoʻopiʻi a hoʻomaikaʻi i ka hāʻawi ʻana i ke koko i ka ischemic myocardium. I ka poʻe maʻi me ka maʻi myocardial infarction, lisinopril me ka nitrates e hōʻemi i ka hoʻokumu ʻana o ka maʻi ventricular hema a i ʻole ʻole ka naʻau.

Hoʻokomo i ka hoʻihoʻi ʻana o ka hana endothelial i hōʻino ʻia i nā mea maʻi me ka hyperglycemia.

Hoomaka ka emi ʻana o ke koko i hoʻokahi hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau i loko a hōʻea i kona nui ma hope o 6 mau hola. ʻO ka lōʻihi o ka hana o ka lisinopril he hilinaʻi i ka dosis a ma kahi o 24 mau hola, e hiki ai iā ʻoe ke hoʻohana i ka lāʻau lapaʻau 1 manawa i kēlā me kēia lā. Me ka lōʻihi o ka mālama ʻana, ʻaʻole i emi ka ulu o ka lāʻau. Me ka hoʻoluhi koʻikoʻi o nā maʻi, ʻaʻole i loli nā loli nui i ke kahe koko (withdrawal syndrome).

ʻOiai ka hopena koʻikoʻi o ka lisinopril e pili ana me ka renin-angiotensin-aldosterone ke kālā, ua maikaʻi ka lāʻau i nā hihia o ke hypertension me kahi haʻahaʻa haʻahaʻa o renin.

Ma ka hoʻohui i kahi emi o ke kahe o ke koko, lisinopril hoʻoemi i ka albuminuria ma muli o nā loli i ka histology a me hemodynamics o ka glomerular apparatus o nā kau.

ʻLoe a me ke kākele

Lawe ʻia ʻo Lisinopril me ka maʻamau, me ka ʻaina ʻole, 1 ka manawa i kēlā me kēia lā, ʻoluʻolu ma ka manawa like.

Hiki ke hoʻohanaʻia ʻo Lisinopril ma ke ʻano monotherapy a i hui pū ʻia me nā lāʻau lapaʻau antihypertensive.

Me ka hypertension arterial, ʻo ka maʻi maʻamau maʻamau o ka lāʻau ma ka 10 mg. I nā mea maʻi me ka hoʻoweliweli koʻikoʻi o ka ʻōnaehana renin-angiotensin-aldosteron (ma ke ʻano he nui, me ka renovascular hypertension, hōʻeha puʻuwai, a i ʻole hypertension koʻikoʻi), ka nui o ka hōʻemi o ke koko ma hope o ka hopena o ka wā mua e loaʻa mai. No laila, ua kuhikuhi ʻia nā mea maʻi i kahi mahele mua o 2.5-5 mg ma lalo o ka mākaʻi o kekahi kauka.

Hoʻomaka ka lāʻau lapaʻau me 5 mg i kēlā me kēia lā i ke kakahiaka. ʻO ka manawa manawa ma waena o ka hoʻonui ʻana i ka dosage he liʻiliʻi ma 3 mau pule. ʻO ka dosis mālama maʻamau ʻo 10-20 mg o Lisinopril 1 ka manawa i kēlā me kēia lā, a ʻo ka nui lahilahi o ka nui o kēlā me kēia lā he 40 mg 1 manawa i kēlā me kēia lā. No ka hoʻonui i ka hoʻoheheʻe koko, pono ʻo Lisinopril e hoʻohui pū me nā lāʻau lapaʻau antihypertensive.

ʻO ka maʻamau, ʻo ka 20 therapeutic dosis ka awelika o 20 mg hoʻokahi i ka lā. Inā ʻaʻole i loaʻa ka hopena therapeutic makemake i loko o nā hebedoma 2-4, hiki ke hoʻonui ʻia i ka hopena.

Pono e ho'ōla i ka hopena diuretic i nā lā 2-3 ma mua o ka hoʻomaka ʻana o ka lawe ʻana iā Lisinopril. Inā ʻaʻohe mea o ka haʻalele o ka diuretics, a laila e pono ai e hoʻomaka i ka hoʻomehana Lisinopril me ka 5 mg o ka lā. Pono e kāohi i ka hana renal a me ka pae o ka serum potassium level.

Laminopril i kau ʻia ma ka hoʻohui ʻia o ke ʻano hana me ka diuretics, glycosides cardiac a i ʻole beta-blockers. I kēia hihia, hoʻomaka, hiki i ka mea hiki, e hoʻemi ʻia ka nui o ka diuretic. ʻO ka inamua hoʻomaka he 2.5 mg i ke kakahiaka. Hoʻokumu ʻia ka hoʻoponopono mālama mālama i nā hana me nā piʻi o 2.5 mg me kahi manawa o nā hebedoma 2-4. ʻO ka papa mālama mālama maʻamau ʻo 5-20 mg hoʻokahi i kēlā me kēia lā. ʻAʻole ia e hāʻawi ʻia ma mua o 35 mg i kēlā me kēia lā.

I ka wā o ka mālama ʻana, pono ʻoe e mālama pono i ke kahe o ke koko, ka hana renal, ke koʻo o ka pāhana a me ka sodium i loko o ka serum koko i mea e pale aku ai i ka hoʻomohala ʻana o ka hypotension a me ka hana i hoʻopalapula i ka hana o ka lua.

Acar myocardial infarction i nā poʻe maʻi me ka hemodynamics paʻa

Hiki ke hoʻomaka i ka mālama ʻana me ka lisinopril i loko o 24 mau hola ma hope o ka mau neocardial infarction (systolic blood pressure nui aʻe ma mua o 100 mmHg, ʻaʻohe hōʻailona o ka renal dysfunction), he mea hou i ka lāʻau maʻamau no ka maʻi myocardial infarction (nā pūlapa thrombolytic, acetylsalicylic acid, beta-blockers, nitrates in mai nā ʻano intravenous a me ke ʻano transdermal).

ʻO ka helu mua ma 5 mg ma hope o 24 mau hola - kahi hou 5 mg, ma hope o 48 mau hola - 10 mg o Lisinopril. A laila aia ka paila he 10 mg 1 manawa i kēlā me kēia lā.

ʻO ka poʻe maʻi me ka hoʻohaʻahaʻa koko systolic haʻahaʻa (≤ 120 mm Hg) e hāʻawi ʻia i ka pona therapeutic haʻahaʻa o Lisinopril, 2.5 mg, ma mua o ka hoʻomaka ʻana i ka hoʻomaʻamaʻa ʻana a i ʻole mau lā 3 mau lā ma hope o kahi hōʻeha o ka naʻau.

E hoʻomau ʻia ka hoʻomanawanui ʻana no nā hebedoma 6. ʻO ka mālama mālamaʻana o ka lāʻau i ka 10 mg i kēlā me kēia lā. Hoʻomaopopo ʻia nā mea maʻi me nā hōʻailona o ka puʻuwai naʻau e hoʻomau i ka maʻi me Lisinopril.

ʻO nā hiʻohiʻona o ka hoʻohana ʻole i ka maikaʻi ʻole

No ka haʻalele ʻana o ka lisinopril ma o nā keiki, ua hilinaʻi ʻia ka hopena mua ma ka puka ʻana o ka creatinine, e pili ana ke ʻano o ka mālama ʻana i nā pane kulekele, a ua koho ʻia me ka mālama pinepine ʻana i nā hana renal, potassium serum a me kā sodium concentrations.

Hōʻailona ka holoʻana (ml / min)

Initial Dose (mg / lā)

3 g / lā, hiki ke hōʻemi i ka hopena hypotensive o nā ACF inhibitors. ʻO ka hoʻohana like ʻana o nā NSAID a me nā inhibitor ACF hiki ke alakaʻi i ka hyperkalemia, a e hoʻopilikia kino i ka hana renal. Hoʻololi pinepine ia kēia hopena, a hiki paha ke ʻike ʻia ana, ʻo ia ka mea mua, i nā mea maʻi me ka hoʻomaʻamaʻa ʻole o ka renal mua. Pono e hoʻokaʻawale ʻia nā hui o nā ACF inhibitors a me NSAID me ka makaʻala, keu i ka poʻe ʻelima a i ʻole nā ​​kānaka dehydrated. Pono ka poʻe maʻi e mālama i kahi kaulike wai kūpono, ma hope o kahi papa hana e pono ai e nānā i ka hana o ka kidney.

Ke hāʻawi ʻia ka ʻā ʻana o ACF a me nā mākaukau gula e like me nā injections (e.g. sodium aurothiomalate), ʻano like nitrate (vasodilation hōʻailona, ​​me ka flush, maʻiʻewaʻi, dizziness a me hypotension, i kekahi mau mea paʻakikī loa) hiki ke ulu pinepine.

ʻO ka hoʻohana like ʻana o nā lāʻau antihypertensive e hiki ke hoʻonui i ka hopena hypotensive o ka lisinopril. ʻO ka hoʻohana pū ʻana o ka lisinopril me ka nitroglycerin, nā nitrates ʻē aʻe, a i ʻole nā ​​vasodilator e hiki ke hoʻohaʻahaʻa i ke koko.

Me ka makaʻala, kuhikuhi i ka lisinopril me ka hoʻohana pinepine ʻana i kekahi mau anesthetics, antidepressants tricyclic a me nā antipsychotics me nā ACF inhibitors ma muli o ka hopena hypotensive.

Hiki i nā Sympathomimetics ke hōʻemi i ka hopena hypotensive o ka hana ACF.

ʻO ka hoʻohana pinepine ʻana o Lisinopril a me nā lāʻau antidiabetic (insulin, waha i ka lāʻau hypoglycemic oral) paha

hoʻoikaika i ka hopena hypoglycemic o ka hopena i ka hopena o ka hypoglycemia. Loaʻa kēia hopena i nā hebedoma mua o ka hui hoʻohui ʻana a i nā mea maʻi me ka maikaʻi ʻole.

Hiki ke hoʻohana i ka Lisinopril i ka manawa like me ka acetylsalicylic acid (ma nā inikua e hāʻawi ai i kahi hopena antiplatelet), thrombolytics, beta-blockers a me / a me nitrates.

Nā ʻōlelo kikoʻī

Phoʻomohalaanomalia arterialhypotension hiki nō i nā mea maʻi me ka hyponatremia a me / a me ka nui o ka hoʻokaʻawale ʻana o ke koko e like me ka mālama ʻana me ka diuretics, ka hoʻohana ʻana i nā diets kūikawā a i ʻole kahi puʻuwai kino o ke kino no nā kumu ʻē aʻe (palauleʻele, hoʻomau a hoʻoliʻi, ʻōpala, dialysis) a me ka puʻuwai pu ʻole. Hoʻokomo ʻia ka mālama ʻana o ka hypotension o ka hoʻomaha hoʻomaha o ka moena a, inā pono, ʻo ka maʻi infusion. ʻO ka emi iki ʻana o ke kahe o ke koko ʻaʻole he contraindication no ka mālama ʻana me Lisinopril, akā naʻe, hiki ke hoʻokaʻawale ʻia ka huina o ka lāʻau a i ʻole ka hōʻemi ʻia ʻana.

Pono e mālama ʻia ka hopena me Lisinopril e ka maʻamau o ka hoʻokaʻawale ʻana o ka hoʻōla wai-electrolyte a me ke kinai ʻana o ka pau ʻana o ke koko koko, ʻoi aʻe, pono ia e nānā i ka loli o ke kahe o ke koko ma hope o ka lawe ʻana i ka ʻōlelo mua.

I loko o nā maʻi cerebrovascular a me ka maʻi puʻuwai coronary, pono e noʻonoʻo ʻia i ka hōʻemi nui o ke kahe koko e hiki ke alakaʻi i ka hoʻomohala ʻana i ka puhopu a i ʻole myocardial infarction.

Ma kaʻeha pūpale myocardial No ka mea, ʻaʻole i ʻōlelo ʻia ʻo ka lisinopril e hoʻomaka i ka poʻe maʻi me nā hōʻailona o ka hana renal impaired, kahi i hoʻoholo ʻia e ka ʻenekena serum creatinine ma mua o 177 μmol / L a me / a proteinuria paha i ka 500 mg / 24 h. Inā hoʻomau ka maʻi renal i ka wā o ka mālama ʻana me ka lāʻau lapaʻau. 265 μmol / l) laila, pono ka hoʻopau ʻana iā ia.

Hoʻopilikiaʻia ka maʻi me ka lisinopril i nā hihia Pāhoʻoloke cardiogenic a me kahi pākuʻi myocardial nuiinā hiki ke koho ʻia he vasodilator e hōʻeha i ka hemodynamics, no ka laʻana, inā ʻaʻole nui aku ka nui o ka systolic i mua o 100 mm Hg

Me ka puʻuwai systolic ʻaʻole iʻoi aku ma mua o 120 mm Hg, nā palena liʻiliʻi o Lisinopril i kuhikuhi mua i nā lā 3 mau lā o ka myocardial infarction - 2,5 mg / lā. Me ka hypotension arterial, hoʻemi ʻia ka nui o ka mālama nei i 5 mg / lā a i ʻole me ka manawa iki i ka 2.5 mg / lā. Me ka hypotension lōʻihi, me ke kaomi systolic ma lalo o 90 mm Hg, ua hoʻopau ʻia ka lāʻau lapaʻau.

Me karenal artery tenosis (bilateral a i ʻole unilateral me hoʻokahiʻōpala)

I loko o kekahi mau mea maʻi me ka stenosis bilateral renal stenosis a i ʻole ka stenosis o hoʻokahi artery kidney, ʻo ke koho iā Lisinopril e hoʻonui i ka pānō o ka urea a me ka creatinine i loko o ka serum koko, kahi, ma muli o ke kānāwai, e hoʻohuli ʻia ma hope o ka hoʻokuʻu ʻana o ka hopena. ʻO kēia ka mea maʻamau i nā poʻe maʻi me ka hana ʻole ʻana.

IHāpai Hoʻopau aia kekahi i mahuahua ka hopena o ka hoʻomohala ʻana i ka hypotension arterial me ka pilikia ʻole. I kēia mau maʻi maʻi, pono e hoʻomaka ʻia ka mālama ʻana me ka lisinopril ma lalo o ka mālama ʻia ʻana o nā lāʻau lapaʻau me nā dosis liʻiliʻi, e ukali ʻia e ka titration

ʻO ka stenosis aortic, mitral valve stenosis, hypertrophic cardiomyopathy

E like me nā inhibitor ACF, pono e hoʻohana ʻia ka lisinopril me ka makaʻala i nā mea maʻi me ka stenosis valve mitral, a me ka valve aortic, a i ʻole hypertrophic cardiomyopathy.

Lele ʻo Angioedema i nā maʻi e loaʻa ana ka ACF inhibitors. I ia mau hihia, pono e hoʻōki i ka lāʻau lapaʻau a pono e kuhikuhi ʻia ka lāʻau kūpono a hiki i ka pau ʻana o nā maʻi lapaʻau o ka edema e hoʻopau loa.

Ma nā hana hoʻomalu ākea a i ʻole me ka hihia o nā lāʻau lapaʻa me ka hopena hypotensive, kālai ʻia ʻo Lisinopril i ka hoʻololi ʻana o ka renin hoʻopaʻi i ka angiotensin-II. ʻO ka hypotension, ka hopena i hiki ke hoʻopau ʻia i nā mīkini i luna, ke hoʻopau ʻia e ka hoʻonui ʻana i ka nui o ke koko kahe.

Hemodialysis/ LDLlipid apheresis / desensitization therapy

Me ka hoʻokaʻawale ʻana o Lisinopril a me ka dialysis me kahi membrane polyacryl-nitrile a i ʻole LDL (haʻahaʻa haʻahaʻa lipoprotein) apheresis me dextran sulfate a i ʻole desensitization e pili ana i nā mea inu kolohe (nā pua, nā wasps), e ulu ka anaphylactic.

Ke kono ʻia nei ʻoe e hoʻohana i kahi membrane dialysis ʻē aʻe a i ʻole ke hoʻoleʻa iki iā Lisinopril me nā lāʻau antihypertensive ʻē aʻe (ʻaʻole ACF inhibitors).

Ma mua o ka desensitization, pono e waiho ʻia ka lisinopril.

ʻO Neutropenia, agranulocytosis, thrombocytopenia a me anemia e nānā ʻia i nā hihia koʻikoʻi loa i nā maʻi e loaʻa ana ka ACF inhibitors. Kēia mau ʻōuli i hope o ka hakahaka o Lisinopril. Pono e hoʻohana ʻia ka lāʻau lapaʻau me ka mālama nui loa i nā maʻi me nā maʻi autoimmune e loaʻa ana i ka immunosuppressants, allopurinol, a i ʻole procainamide. Ke hoʻohana ʻia nei ka lisinopril i kēlā mau mea maʻi, e nānā ʻia ka nānā ʻana o ka pae o ka leukocytes i ke koko.

Nhoʻoilinaaymololologalactose poino Lapp lactase,maʻi maʻi glucose malabsorption - galactose

ʻAʻole pono ke hāʻawi ʻia ʻo Lisinopril i ka poʻe maʻi me ka nānā ʻana i ka intolerance galactose maʻamau i ʻike ʻia, nā hemahema o Lapp lactase a i ʻole kahi maʻi o ke kōpona o ka maʻi o ka puʻuwai - galactose ma muli o ka hiki ʻana o ka lōmole lactose i ka hoʻopili ʻana.

Nā hiʻohiʻona o ka hopena o ka lāʻau lapaʻau ma ka hiki ke hoʻokau i kahi kaʻa a lawelawe paha

ʻOiai e lawe ana iā Lisinopril, ʻaʻole ʻia no ka holo ʻana i kahi kaʻa a hana pū me nā mea hoʻopilikia pōʻino, ma muli o ka hiki ke hoʻomohala ʻia.

Ke keu

Nā Hoʻomaka hipotension koʻikoʻi a hiki i kahi kūlana pīhoihoi, hyperkalemia, bradycardia, tachycardia, pōkole o ka hanu, pilikia ʻole, wīwī, huki, hopohopo.

Lāʻau: gastage lavage, kōkuhi o adsorbents a me ka sodium sulfate ma hope o ka lawe ʻana i nā papa Lisinopril i loko. Pono e kāohi i ka hoʻāla ʻana o ka wai-electrolyte a me ka ʻike serum creatinine.

Ua kau ʻia ke ʻano maʻi Symptomatic, ka ʻina hoʻokele o ka wai o 0.9% sodium chloride solution, agonist adrenergic me hypotension koʻikoʻi. Me ka bradycardia, e lawelawe ʻia ana ka atropine, inā pono, hiki ke noʻonoʻo pono i ka hoʻonohonoho ʻana o kahi pacemaker. Hoʻopau ʻia ʻo Lisinopril e ka hemodialysis.

E hoʻokuʻu i ke ʻano a me ka pale

Ma nā papa 10 ma kahi pale polū blister mai kahi kiʻi o polyvinyl chloride a me ka alumini foil.

3, 5 mau pākeke pālua me nā ʻōlelo aʻoaʻo i ʻae ʻia no ka hoʻohana ʻana i nā lāʻau lapaʻau ma ka'āina a me nā ʻōlelo Lūkini e waiho ʻia ana ma loko o kahi kāleka.

Hāʻawi ʻia nā paila blister (me ka ʻole o ka hoʻopili ʻia ʻana i kahi pūpele o ke kāleka) i waiho ʻia i loko o nā pahu pepa. Wahi a ka helu o nā pākuhi, ua kau ʻia nā ʻōlelo aʻoaʻo no ka hoʻohana olakino i ka mokuʻāina a me nā ʻōlelo Lūkini ma kēlā me kēia pahu.