ʻO Roxeracene, e loaʻa, kūʻai > Nā lāʻau lapaʻau

Trade inoa o ka lāʻau lapaʻau: Roxera

Inoa Kūʻai ʻole honua: Rosuvastatin (Rosuvastatinum)

Pākuʻi helu: papa hana i ʻālani ʻia

Mea waiwai: rosuvastatin

ʻĀpana Pharmacotherapeutic: lāʻau lapaʻau lipid-hōʻemi.

ʻO ka lāʻau hypnotolesterolemic a me hypotriglyceridemic. HMG CoA reductase inhibitors.

Lapaʻa lāʻau:

ʻO ke hana o ka mākaukau roxer ke kuhikuhi i ka hana ʻana i ka hana o ka microsomal enzyme hydroxymethylglutaryl-CoA reductase, e hana ana i ka wai no ka hoʻopiha ʻana i ka wā mua o ka paeʻana o ka synt synthesis.

Ka hopena o ka hōʻailona lipid profile (ka hopena lipid-hoʻohaʻahaʻa) ma muli o ka emi ʻana o ke kahe o ke koko o ka nui o ka kolamu, triglycerides, lipoproteins haʻahaʻa haʻahaʻa, a me ka hoʻonui ʻana i nā mea hou i nā lipoprotein density. No ka lāʻau lapaʻau i loko o ka lāʻau lapaʻau lāʻau "Statins".

Nā hōʻailona no ka hoʻohana ʻana:

ʻO ka hypercholesterolemia primati (ke ʻano IIa ma muli o Fredrickson) a i ʻole ʻae ʻia ka dyslipidemia (type IIb ma muli o Fredrickson) he kumumea i ka papa me ka maikaʻi ʻole o ka ʻai ʻana a me nā ʻano lāʻau ʻē aʻe o ka lāʻau lapaʻau (ʻo ka laʻana, ka hana kino, ke kaumaha ʻana), ka hypercholesterolemia homozygous i hoʻohui ʻia i ka mea ʻai a me nā ʻano ʻē aʻe. lipid-haʻahaʻa haʻahaʻa (no ka laʻana, LDL-apheresis) a i ʻole ʻole ka hopena o ia ʻano maʻi, ʻo hypertriglyceridemia (Fredrickson ʻano IV) he hoʻohui i ka meaʻai, e hoʻolohi i ka holomua o ka atherosclerosis e like me ka ʻelua hoʻohui i ka papaʻai i nā poʻe maʻi e hōʻike ʻia ana e ka hoʻokaʻawale i ke kaila o ka plasma o Chs a me Chs-LDL, ka pale mua ʻana i nā hoʻopiʻi o ka maʻi cardiovascular (stroke, myocardial infarction, arterial revascularization) i nā maʻi maʻi me ka ʻole o nā hōʻailona o ka maʻi coronary artery maʻi, akā me ka piʻi nui o kona hoʻomohala (ʻoi aku ma mua o 50 no nā kāne a ʻoi aku ma luna o 60 no nā wahine, ka kiʻekiʻe o ka plasma kiʻekiʻe o ka protein C-reactive (≥2 g / l) i mua i ka liʻiliʻi o kekahi o nā mea e pili ana i ka maʻi, e like me ke kaila hypertension Zia, ka mea haahaa wai koko lehulehu o HDL-Xc, pūnuku puhi, i kakahiaka nui coronary artery maʻi i loko o kaʻohana mōʻaukala).

ʻO ka hapai a me ka lactation - ua hoʻohua ʻo Roxer i ka wā hāpai a me ka lactation. Pono nā wahine o nā makahiki hānau hānau i nā ala kūpono o ka contraception.

No ka mea nui ka kolamu a me nā mea i hoʻohuihui ʻia mai ka kolamu he mea nui no ka hoʻomohala ʻana o ka pūpū, hiki i ka hiki ke hoʻololi i ka HMG-CoA reductase no ka pūpū he keu i nā pōmaikaʻi o ka hoʻohana ʻana i ka lāʻau i ka wā hāpai.

I ka hihia o ka hāpai ʻana i ka wā e hoʻōla ai, e hoʻopau koke ka hoʻohana ʻana i ka lāʻau.

ʻAʻohe ʻikepili i ka excretion o rosuvastatin me ka umauma wai (ʻike ʻia e hiki ke hoʻokaʻawale ʻia nā mea ʻē aʻe o ka HMG-CoA i ka waiū umauma), no laila ke hoʻohana pono ʻia ka lāʻau lapaʻau i ka wā o ka mālama ʻana i ka umauma.

Nā pālua:

Me kahi lā o kēlā me kēia lā a hiki i ka 30 mg

ʻO nā maʻi o ka puʻuwai ma ka hana ikaika (me ka hoʻomau mau ʻana o ka hana o ka transaminases hepatic a me ka hoʻonui ʻana i ka hana o nā transaminases hepatic i loko o ka serum koko ma mua o 3 mau manawa e hoʻohālikelike ʻia me VGN), hōʻeha o ka renal nui (CC ma mua o 30 ml / min), myopathy, hoʻohana paʻa o ka cyclosporine, nā mea maʻi predisposed i ka hoʻomohala ʻana o nā hoʻopiʻi myotoxic, hapai, ka manawa o ka hānai, hoʻohana i nā wahine o ka hānau ʻana o ka wā hānau ʻole i hoʻohana i nā ʻano kūpono o ka contraception, lolous lolole, lactose defact. PS, monakō koko-galactose malabsorption maʻi pale, makahiki 18 makahiki, hypersensitivity e rosuvastatin paha i kekahi ke keʻena o ka lāʻau.

Me kahi lā o kēlā me kēia lā he 30 mg a i ʻole.

hōʻeha i ka nāwaliwali kūleʻa nui loa (CC ma mua o 60 ml / min), hypothyroidism,

nā maʻi ʻeha ma ka mōʻaukala (e pili ana i ka mōʻaukala), myotoxicity me nā HMG-CoA reductase inhibitors a i ʻole fibates i ka mōʻaukala, ka inu wai ʻokoʻa nui, nā kūlana e hiki ke alakaʻi i ka piʻi ʻana o ka plasma o rosuvastatin, i ka manawa like o nā fibrates. nā mea maʻi o ka lāhui Mongoloid.

Me ka mālama akaʻana i ka lā maʻamau a hiki i ka 30 mg:

ʻoi aku ma mua o 65 mau makahiki, hypotension arterial, ka nui o ka hōʻeha, ka trauma, ka metabola koʻikoʻi, nā endocrine a i ʻole electrolyte hoʻonā a i ʻole e hopu ʻia i nā kahakaha, ka manawa like me ka ezetimibe.

Nā ʻoslelo a me ke hoʻoponopono:

Lawe ʻia ka lāʻau lapaʻau. Maiʻaʻi a ʻaʻa ʻole i ka papa ʻaina, ʻūʻai piha, holoi ʻia me ka wai, hiki ke lawe ʻia i kēlā me kēia manawa o ka lā, me ke ʻano o ka kō ʻana o ka meaʻai.

Ma mua o ka hoʻomaka ʻana i ka maʻi maʻi me kahi lāʻau maʻi roxer, pono e hoʻomaka ka mea maʻi e hahai i ka maʻamau hypocholesterolemic diet a hoʻomau ma muli o ia i ka wā e mālama ai. Pono ke koho o ka lāʻau lapaʻau e koho kuʻuna i ka pahuhō o nā pahuhopu a me ka pane ʻana i ka therapeutic i ka mālama ʻana, i ka nānā ʻana i nā ʻōlelo ʻōiwi o ka nūnū i nā mea pili i ka lipid plasma.

ʻO ka papa hoʻomaka ʻana i nā maʻi e hoʻomaka ana e lawe i ka lāʻau lapaʻau, ai ʻole no nā mea maʻi i hoʻihoʻi mai i ka lawe ʻana i nā HMG-CoA reductase inhibitors, pono ʻia he 5 a 10 mg mau hoʻokahi i ka lā.

Me ka hoʻohana like ʻana o ka lāʻau lapaʻau me ka gemfibrozil, fibrates, ka waikika nicotinic i loko o kahi pane o ka nui o 1 g i kēlā me kēia lā, ʻōlelo ʻia nā mea maʻi e hoʻomaka i kahi kaha o 5 mg. Ke koho ʻana i kahi pualikoa mua, pono alakaʻi ʻia e kekahi o ka plasma cholesterol kanaka ponoʻī a e noʻonoʻo i ka hiki pono ʻana i ke ʻano o ka hoʻomohala ʻana i nā hoʻopiʻi cardiovascular, a ʻoi paha ka hopena o ka hopena o ka hopena i mea e ʻike ʻia. Inā kūpono, e hoʻonui ʻia ka pākeke ma hope o nā 4 hebedoma.

Ma muli o ka hiki ke hoʻomohala ʻana i nā hopena hopena i ka wā e kau ai i kahi maʻa o 40 mg i kēlā me kēia lā, hoʻohālikelike ʻia me nā haʻahaʻa haʻahaʻa o ka lāʻau, ke hoʻonui nei i ka momona i 40 mg i kēlā me kēia lā ma hope o kahi pane hou aʻe e ʻoi aku ka ʻoi ma mua o ka hopena i hoʻomaka ʻia no nā wiki he 4 e hiki ke mālama ʻia i loko. nā mea maʻi me ka maʻi koʻikoʻi o ka hypercholesterolemia a me ke kiʻekiʻe o ka hoʻouluʻana i nā hoʻopiʻi cardiovascular (ʻoi aku hoʻi i nā poʻe maʻi me ka hypercholesterolemia familial) ʻaʻole i loaʻa i ka hopena makemake e loaʻa ai ka hopena me kahi maʻi 20 mg i kēlā me kēia lā, RS ka mea, e ia ma lalo o ka hooponopono ana o ke kauka. ʻAno e mālama pono i ka mālama ʻana i nā maʻi e loaʻa ana i ka lāʻau lapaʻau ma kahi maʻa o 40 mg i kēlā me kēia lā.

ʻO ka hoʻohana ʻia ʻana o kahi waihona no 40 mg i kēlā me kēia lā i nā maʻi me ka nīnau ʻole ma mua o kahi kauka. Ma hope o 2 mau hebedoma e pili ana i ka mālama ʻana a me / a me ke hoʻonui ʻana o ka nui o ka mākaukau ʻo ka roxer, nānā pono ana i ka lipid metabolism e pono ai (pono ʻia ka hoʻoponopono ʻana inā pono).

I nā mea maʻi me ka hōʻemi ʻole ʻana a me ka hoʻololi ʻole, ʻaʻole i koi ʻia ka hoʻoponopono ʻana. I ka poʻe maʻi me ka hiki ʻole o ka pilikia renal (CC ma mua o 30 ml / min), ua contraindicated ka hoʻohana ʻana o ka roxer. ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau ma loko o kahi pōʻai o ʻoi aku ma mua o 30 mg i kēlā me kēia lā ke contraindicated i nā mea maʻi me nā maʻi a me ka hōʻeha ʻana i ka maʻi (CC ma mua o 60 ml / min). No nā mea maʻi me ka hikiʻole i ka renal moderate, ʻo ka ʻōlelo i hoʻomaka ʻia o ka lāʻau no 5 mg i kēlā me kēia lā.

Ua hoʻohālikelike ʻia ʻo Roxer i nā maʻi me nā maʻi pūpū ikaika. ʻAʻoheʻike i ka hoʻohana ʻana i ka lāʻau lapaʻau i nā mea maʻi me ka hōʻoki ʻana o ka ate ma luna o 9 mau māka (papa C) i kā ke keiki-Pugh.

Hoʻomaopopo ʻia nā mea maʻi ma luna o ka 65 makahiki e hoʻomaka i ka hoʻohana ʻana i ka lāʻau lapaʻau me kahi maʻi o 5 mg i kēlā me kēia lā.

Ke aʻo nei i nā lāʻau lapaʻau pharmacokinetic o rosuvastatin i nā poʻe maʻi e pili ana i nā ʻano like ʻole o ka iwi, ua ʻike ʻia ka nui o ka neʻe ʻana o ka systemic o rosuvastatin ma waena o Iapana a me Kina. Pono e mālama i kēia ʻoiaʻiʻo i ka wā e hoʻohana ai i ka lāʻau ʻo Roxer i kēia mau mea maʻi. Ke hoʻohana nei i nā kaila o 10 a me 20 mg i kēlā me kēia lā, ʻo ka pona i hoʻomaka ʻia no nā mea maʻi o ka lāhui Mongoloid he 5 mg i kēlā me kēia lā. ʻO nā maʻi o ka lāhui Mongoloid, ke hoʻohana ʻana i ka lāʻau lapaʻau ma kahi pānaʻi o 40 mg ua contraindicated.

ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau i loko o kahi maʻa o 40 mg ua contraindicated i loko o nā mea maʻi e predisposed i ka hoʻomohala ʻana i nā hoʻopiʻi myotoxic. Inā pono e hoʻohana i nā inikua o 10 a 20 mg i kēlā me kēia lā, ʻo ka pona hoʻonaʻau mua ʻia no kēia pūʻulu o nā maʻi he 5 mg.

I ka manawa e hoʻohana ai me ka gemfibrazil, ʻaʻole pono ka nui o ka hopena o ka hoʻomākaukau ʻana i ka roxer i ka 10 mg i kēlā me kēia lā.

Hoʻopili ʻana me nā lāʻau lapaʻau ʻē aʻe:

ʻO Cyclosporine - me ka hoʻohana like ʻana o rosuvastatin a me ka cyclosporine, ʻo ka AUC o rosuvastatin ma ka manawa 7 e kiʻekiʻe aʻe ma mua o kēlā i nānā pono ai i nā mea hana olakino. ʻO ka plasma plasma o ka rosuvastatin e piʻi aʻe e 11 mau manawa.

ʻO ka hoʻohana like ʻana me ka rosuvastatin ʻaʻole i pili i ka ʻike o ka cyclosporine i loko o ke kaila koko.

ʻO nā anticoagulants kūloko - e like me nā HMG-CoA reductase inhibitors, e hoʻomaka ana i ka maʻi rosuvastatin a e hoʻonui ana i kona maʻi i nā maʻi e lawe ana i nā anticoagulants kūlohelohe i ka manawa like (me ka laʻana, warfarin) hiki ke alakaʻi i ka piʻi i loko o MHO. ʻO ka hoʻoneʻe ʻana o rosuvastatin a i ʻole ka hōʻemi ʻana i kona makeʻana hiki ke piʻi i kahi kaila o ka MHO. I kēlā mau kūlana, ua hōʻike ʻia ka nānā ʻana o MHO.

Ezetimibe - ka hoʻohana like ʻana o rosuvastatin a me ezetimibe i hele ʻole ʻia e kahi loli ma AUC a i ʻole Cmax o nā lāʻau ʻelua. Eia nō naʻe, ʻaʻole hiki ke hoʻokele ʻia ka launa lapaʻau pharmacodynamic ma waena o rosuvastatin a me ezetimibe.

ʻO Gemfibrozil a me nā lāʻau hoʻoneʻe lipid-hoʻohaʻahaʻa iho - ʻo ka hoʻohana like ʻana o rosuvastatin a me gemfibrozil e alakaʻi i kahi hoʻonui 2-piha i Cmax a me AUC o rosuvastatin. ʻO Gemfibrozil, fenofibrate, e hoʻohālikelike i ka wai, a me nā lipid-hoʻohaʻahaʻa i ka wai momona nikotinic (ʻeha nui a i ʻole ka like me ka 1 g i kēlā me kēia lā) hoʻonui i ka hopena o ka myopathy i ka wā i hoʻohana pū ʻia me HMG-CoA reductase inhibitors (pono paha ma muli o ka manaʻo hiki iā lākou ke hoʻomau i ka myopathy hoʻi i ka wā i hoʻohana ʻia ai. monotherapy). ʻO ka hoʻohana like ʻana o nā fibrates a me ka rosuvastatin i loko o kēlā me kēia lā o 30 mg ua contraindicated. I kēlā mau mea maʻi, pono e hoʻomaka ka lāʻau maʻi me kahi maʻi o 5 mg i ka lā.

ʻO nā pale o ka protease HIV - ka hoʻohana like ʻana o nā mea pale o ka protein protease hiki ke hoʻonui i ka neʻe o ka plasma o rosuvastatin. ʻO ka hoʻohana like ʻana o 20 mg o rosuvastatin a me ka hui pū ʻana me ʻelua mau proteides inhibitor (400 mg o lopinavir / 100 mg o ritonavir) ka ukali ʻia e ka piʻi ʻana o ka AUC kūlele (0-24 h) a me Cmax o ka rosuvastatin ma 2 a me 5 mau manawa, ia.

Antacids - ka hoʻohana like ʻana o rosuvastatin a me nā antacids e loaʻa ana i ka alumini a me ka hoʻōla konupena magnesium, ke alakaʻi nei i ka emi ʻana o ka plasma o ka rosuvastatin ma kahi o 50%. Hōʻike ʻia kēia hopena inā hoʻohana ʻia nā antacids i mau hola 2 ma hope o ka lawe ʻana i ka rosuvastatin.

Erythromycin - ka hoʻohana like ʻana o rosuvastatin a me ka erythromycin e alakaʻi i kahi emi o AUC (0-t) o rosuvastatin e 20% a me kāna Cmax e 30%. Hiki i kēlā hōʻiliʻili ʻano hopena ma muli o ka nui o ka motility intestinal i kumu e ka hoʻohana ʻana o ka erythromycin.

Hoʻopilikia / hoʻohālikelike ʻoi aku ka hormonal therapy (HRT) - ka hoʻohana like ʻana o rosuvastatin a me nā contraceptive hormonal e hoʻonui i ka AUC o ka ethinyl estradiol a me norgestrel e 26% a 34%, kekahi. Pono e hoʻonui ʻia i ka neʻe ʻana o ka plasma i ka wā e koho ai i ka nui o ke ʻano o nā mea hoʻohālikelike hormonal. ʻAʻohe data data pharmacokinetic ma ka hoʻohana like ʻana o ka rosuvastatin a me ka hoʻololi ʻana i ke kaila o ke ʻano, no laila, ʻaʻole hiki ke haʻalele ʻia kahi hopena like me ka hoʻohana ʻana i kēia hui. Akā, ua hoʻohana nui ʻia kēia hui i ka wā o nā hoʻokolohua lapaʻau a ua hoʻomanawanui maikaʻi ʻia e nā mea maʻi.

Digoxin - No kēlā me kēia ʻano nui o ka rosuvastatin me ka digoxin i kali ʻia.

ʻO Isoenzymes o ka cytochrome P450 - ʻo rosuvastatin ʻaʻole ia he mea e pale aku ai ʻole i ka mea hoʻohana ʻole o ka cytochrome P450. Eia kekahi, ʻo ka rosuvastatin kahi palupalu nāwaliwali o kēia ʻōnaehana isoenzyme. ʻAʻohe ʻano kikino o ka maʻi ma waena o rosuvastatin a me fluconazole (kahi mea paʻa o ka isoenzymes CYP2C9 a me CYP3A4) a me ketoconazole (kahi mea paʻa o ka isoenzymes CYP2A6 a me CYP3A4). ʻO ka hoʻohana like ʻana o rosuvastatin a me ka itraconazole (kahi hoʻomehana o ka isoenzyme CYP3A4) e hoʻonui i ka AUC o ka rosuvastatin e ka 28%, ka mea lapaʻau ʻole. No laila, ʻaʻole i manaʻo ʻia ka pilina pili me ka cytochrome P450.

Ke keu:

ʻAʻole hoʻākāka ke kiʻi kaukau maʻi o ka overdose.

Me kahi pākahi hoʻokahi o nā helu i kēlā me kēia lā o ka lāʻau, ʻaʻole i loli nā hiʻohiʻona pharmacokinetic o rosuvastatin.

Hoʻomaʻamaʻa: nā hōʻailona, ke nānā ʻana i ka hana o ka ate a me ka hana CPK he mea pono, ʻaʻohe ʻano antidote kikoʻī, hemodialysis pono ʻole.

Nā hopena hopena:

ʻO ka helu ʻana i nā mea e pili ana i ka hopena: pinepine pinepine (> 1/10), pinepine (> 1/100, akā ʻo 1/1000, akā 1/10 000, akā

Nā hōʻailona no ka hoʻohana ʻana

He aha ka mea e kōkua ai iā Roxer? Kāhea i ka lāʻau lapaʻau i loko o nā hihia penei:

diclipidemia i hui ʻia a i ʻole hypercholesterolemia mua (ma ke ʻano o ka meaʻai me ka hiki ʻole o nā lāʻau lapaʻau ka lāʻau lapaʻau - hōʻemi ka momona, ka hana kino, a pēlā aku).
ʻO ka hypercholesterolemia homozygous homozygous (i ka hoʻohui i ke ʻano o ka hana o ka mua)
ʻano IV hypertriglyceridemia (ma ke ʻano he kīʻaha)
ka hoʻomohala ʻana o ka atherosclerosis i nā poʻe maʻi i kuhikuhi i ka lāʻau no ka emi ʻana o ka neʻe ʻana o ka Xc a me Xs-LDL i ka plasma,
ka pale mua ʻana i ka maʻi ʻeha o ka naʻau (arterial revascularization, myocardial infarction, stroke) i nā mea maʻi me kahi predisposition e pili i ka maʻi arteri coronary, me ka maʻi kahiko.

Nā ʻōkuhi no ka hoʻohana iā Roxer, dosis

Ua kuhikuhi ʻia nā palapala me hoʻokahi, ma lalo o ka kaohi o ka cholesterol i ka plasma koko. Ua inu lākou i ka lāʻau lapaʻau e pili ana i ka meaʻai, holoi ʻia me ka wai. Wahi a nā ʻōlelo kuhikuhi, ʻaʻole eʻoi aku ka hopena mua ma mua o ka 1 papa o Roxer 5 mg / 10 mg hoʻokahi i ka lā.

ʻO ka dosage nui loa he 40 mg i kēlā me kēia lā.

Ke kau nei i ka hapa nui o 40 mg pākahi i kēlā me kēia lā hiki wale nō no ka poʻe maʻi me ka maʻi koʻikoʻi o ka hypercholesterolemia a me ka manawa kiʻekiʻe e hoʻopiʻi ʻia mai nā ʻōnaehana cardiovascular (maʻa mau loa i ka hihia o ka hypercholesterolemia familial), kahi i kū ʻole ai ka hopena i makemake ʻia me 20 mg i kēlā me kēia lā. Pono e hoʻokō pono i ke ʻano maʻi ma lalo o ka nānā mālama olakino.

Lawe i ka lāʻau lapaʻau ma kahi maʻa o 40 mg i kēia lā i nā maʻi i ʻike ʻole ʻia e kekahi kauka. Ma hope o nā hebedoma o ka hoʻohana ʻia ʻana o 2 mau hebedoma a i kēlā me kēia hoʻonui o ka nui o ka lāʻau, pono ia e nānā i ka lipid metabolism (inā pono, pono ʻia ka hoʻoponopono hoʻoponopono).

ʻO ka nui o ka 20 mg / lā ka lōʻihi no nā mea lawe aku i nā genotypes c.521CC a i s.421AA. Hiki ke kau ʻia ka nui o ka nui (40 mg) i nā mea maʻi me ka maʻi nui o ka hoʻonui ʻana i ka cholesterol a me ka kiʻekiʻe o nā hōʻeha o ka naʻau.

ʻO ka lawe ʻana i nā anticoagulants (warfarin, etc.) i ka manawa like me ka statin hiki i ke koko, a me ka glycosides cardiac (no ka laʻana, digoxin) - hoʻonui i ka manaʻo o ka hopena.

ʻO ka hopena therapeutic e lawe nei ka mea i waena o 5-8 mau lā, a me ka hopena kiʻekiʻe - e ka 3-4 mau lā o ka mālama.

Nā hopena hopena

E like me nā ʻōlelo a ke hoʻohana, hiki ke koho ʻia ʻo Roxer e nā ʻāpana hope:

Ma ka ʻāpana o ka ʻōnaehana pale: angioedema a me nā hopena ʻē aʻe e pili ana me ka hypersensitivity.
Mai ka pūnaehana hoʻonāukiuki: dizziness, headache, loss memory, polyneuropathy.
Mai ka ʻeha o ka gastrointestinal: ʻeha i loko o ka ʻōpū, nausea, constipation, pancreatitis, hepatitis, jaundice, ʻeha, hoʻonui i ka hana o nā transaminases hepatic.
Mai ka ʻili: ʻōlohelohe, ʻehala, maʻi ʻo Stevens-Jones.
Mai ka paewa ʻana a me ka ʻōnaehana muscular: myalgia, myopathy, rhabdomyolysis.
Mai ka urinary system: proteinuria, hematuria.
Laua: asthenia.

Nā Hoʻohui

Hoʻohui ʻia ia e kuhikuhi iā Roxer i kēia mau pilikia aʻe:

hypersensitivity i rosuvastatin a i ʻole kekahi o nā mea pono lāʻau,
maʻi pūpū i ka hana ikaika (me ka hoʻomau nei mau i ka hana o nā transaminases hepatic a me ka hoʻonui ʻana i ka hana o nā transaminases hepatic i loko o ka serum koko ma mua o 3 mau manawa e hoʻohālikelike ʻia me VGN).
hōʻino nā mea a me ka hikiʻole o ka pilikia o ka hakahaka (hana i ʻoi aku ma lalo o 60 ml / min),
myopathy
hana kuikahi
nā mea maʻi i hoʻomaka mua i ka hoʻomohala ʻana i ka hoʻopiʻi myotoxic,
hapai, hapai
hoʻohana ma nā wahine o ka hānau keiki keiki ʻaʻole i hoʻohana i nā ʻano kūpono o ke kō.
hypothyroidism
ka mōʻaukala o nā maʻi ʻeha (ʻo ka mōʻaukala ʻohana),
myotoxicity i ka wā e hoʻohana ai i ka mōʻaukala hou o HMG-CoA reductase inhibitors a fibrates paha,
inu waiʻona nui
nā kūlana e hiki ke alakaʻi i ka hoʻonui ʻana i ka ʻike o rosuvastatin i loko o ke koko koko,
i ka manawa like o nā fibrates,
lactose intolerance, lactase hemahema, glucose-galactose malabsorption syndrome,
Nā maʻi maʻi Mongoloid
makahiki i 18 makahiki.

Ke keu

ʻAʻohe ʻikepili e pili ana i ke kiʻi kaukau o ka overdose. Ka nānā ʻana i ka palena o ka pharmacokinetic o ka mea ikaika i ka wā e lawe ai i nā dosie kiʻekiʻe ʻaʻole mālama ʻia.

ʻAʻohe Rosidvatinatin kahi hopena antidote; hemodialysis hiki ʻole. I nā hihia o ka overdose, lawe ʻia ke ʻano hōʻailona ma lalo o ka kāohi ʻana o ka hana o ka ate a me ka hana phosphokinase.

ʻO nā mea hoʻohālikelike o Roxer, ke kumukūʻai i nā lāʻau lapaʻau

Inā pono, hiki iā ʻoe ke kahakaha iā Roxer me ka analogue no ka mea ikaika - eia nā mau lāʻau lapaʻau.

Rosulip,
Kēlā
Rosart,
Kelemania,
Lipoprime,
Manuela
Suvardio
Kalima,
Rosufast,
Rosucard.

Ke koho nei i nā mea kikoʻī, pono e hoʻomaopopo i nā kuhikuhi no ka hoʻohana ʻana iā Roxer, ke kumukūʻai a me nā loiloi o nā lāʻau lapaʻau me nā hopena like ʻole. He mea nui ia e kamaʻilio pū me ke kauka kauka a ʻaʻole hoʻi e hana i kahi loli kūʻokoʻa kūʻokoʻa.

ʻO ke kumukūʻai ma nā lāʻau lapaʻau Lūkini: papa nā Roxer 5 mg 30 pcs. - mai 384 a 479 mau rubles, 10 mg 30 pcs. - mai 489 a 503 mau rubles, 15 mg 30pcs. - mai 560 rubles.

Store ma nā wela a hiki i 25 ° C. Mai mālama i nā keiki. ʻO 3 mau makahiki kahi ola. I loko o nā haleʻai, he waiho kauka a kauka.

Wahi a nā kauka, ʻo Roxer e hoʻohaʻahaʻa i ka cholesterol. Ua hōʻike ʻia e hoʻomaka nei ka lāʻau i kahi hopena therapeutic wikiwiki ma mua o nā mea hana like me nā hopena like. Me ka hoʻomanawanui maikaʻi, hiki i ka therapy lōʻihi. I waena o nā hemahema e hōʻike ana i kahi kumukūʻai nui loa a me ka hoʻomohala ʻana o nā hopena ʻaoʻao.

3 loiloi no ka "Roxer"

Me kēia mau palaka, hoʻohaʻahaʻa ia i ke kolamu koko i ʻelua mau mahina mai 9 a 5.8, hiki ke maʻalahi maʻalahi (ʻokoʻa ka huila ʻole o ke poʻo hōʻeha i ke ahiahi), e hana mālie ana ia, me ka ʻole o ka alaka. Kauka ke kauka e hana mau, ke kaumaha nei ke kumukū o ka lāʻau lapaʻau, he mea liʻiliʻi loa ia iaʻu.

ke hoʻomaka koke nei nā ʻaihue, oki i ka lawe ʻana i ka lāʻau lapaʻau, kōkua nui i kekahi, akā ʻaʻole ka mea āpau.

Ua hoao au. Loaʻa ka holomua i ka hopena o ka pule mua, akā i ka like mau aʻu ma kahi o kahi meaʻai. Lawe ʻo ia i ka lāʻau lapaʻau no ka manawa lōʻihi, ma kahi o 1.5 mau makahiki me kahi hoʻomaha o 2 mau mahina. ʻO nā haʻahaʻa o kā Cholesterol.

E hoʻokuʻu i ke ʻano

Loaʻa iā Roxer i ke ʻano o nā papa i hui pū ʻia me ka membrane kiʻi keʻokeʻo, ʻokoʻa ka mea nānā i ke ʻano o ka neʻe ʻana o ka mea hana ma loko o lākou:

Nā papa hana me nā ʻike rosuvastatin ma ke kūlohelohe o 5, 10 a i ʻole 15 mg, he ʻano pōpoki, ka biconvex, me ka bevel. Ma ka ʻaoʻao hoʻokahi ka hoʻopaʻa inoa ʻana e like me ka pona o nā mea ikaika: "5", "10" a me "15", kēlā.
Nā papa hana me nā ʻike rosuvastatin ma ke ʻano o 20 mg, hoʻopuni, biconvex, me kahi bevel.
Nā papa hana me nā ʻike rosuvastatin ma kahi pahu o 30 mg, biconvex, he kime pōpilikia a me nā pilikia ma nā ʻaoʻao ʻelua.
Nā papa hana me nā ʻike rosuvastatin i kahi manawa o 40 mg, biconvex, he ʻano capsular.

Ma ka slice o ka papa, ʻike ʻia nā papala ʻelua, ke keʻokeʻo o loko.

Ka hana lāʻau lapaʻau

Ke hōʻike nei i ka hopena lāʻau lapaʻau e hōʻike iā Roxer:

Ke hōʻike nei i ka hana hoʻoulu a microsomal hydroxymethylglutaryl-CoA reductasee hana ana he ʻano mea e hoʻomau ai i ka hoʻomaka mua o ka synthesis kolamu.
Ka hopena o ka ʻike lipid (ʻO ka hopena lipid-haʻahaʻa) ma muli o kahi emi o ke koko pauku kūʻokoʻa kolamu, triglycerides, lipoproteins haʻahaʻa haʻahaʻa a ʻo ka piʻi ʻana i ka ʻike lipoproteins kiʻekiʻena kiʻekiʻe.

No ka lāʻau lapaʻau ka hui ".Nā ʻāpana”.

Pharmacodynamics a me ka pharmacokinetics

Hoʻokahi i ke kino rosuvastatin ua hoʻonāukiuki i nā hopena aʻe:

Kōkua e hōʻemi i nā kiʻekiʻe kiʻekiʻe kolamu lipoprotein haʻahaʻa haʻahaʻa,
Kōkua i ka hoʻemi ʻana i nā mea i hoʻokiʻekiʻe ʻia kolamu,
Kōkua i ka hoʻokiʻekiʻe ʻana o nā kukuna triglyceride kiʻekiʻe,
Hoʻohui i nā hoʻonui ʻana koloprotein kūloko kiʻekiʻe,
Kōkua i ka hoʻohaʻahaʻa ʻana i ka paʻa lipoprotein haʻahaʻa haʻahaʻa apopipoprotein (apoliprotein B),
Kōkua i ka hoʻohaʻahaʻa ʻana i ka paʻa kolamu lipoprotein haʻahaʻa haʻahaʻa,
Kōkua i ka hoʻohaʻahaʻa ʻana i ka paʻa lipoprotein haʻahaʻa haʻahaʻa loa,
Kōkua i ka hoʻohaʻahaʻa ʻana i ka paʻa lipoprotein haʻahaʻa haʻahaʻa haʻahaʻa triglycerides,
Hoʻohui i ka ʻĀina pili koko plasma apoliprotein A1,
ʻO ka pae haʻahaʻa haʻahaʻa haʻahaʻa lipoproteins haʻahaʻa haʻahaʻai koloprotein kūloko kiʻekiʻe,
Hoʻemi i nā kuʻuna holoʻokoʻa kolamu i koloprotein kūloko kiʻekiʻe,
Hoʻemi i nā kuʻuna kolamu lipoprotein haʻahaʻa haʻahaʻa i lipoprotein kūloko kiʻekiʻe,
Hoʻemi i nā kuʻuna lipoprotein haʻahaʻa haʻahaʻa apopipoprotein (apoliprotein B) ka apolipoprotein A1.

Hoʻolaha ka hopena lapaʻau haʻi i ka hoʻohana ʻana iā Roxers i hoʻokahi pule ma hope o ka hoʻomaka ʻana o ka papa o ka mālama ʻana me ka lāʻau lapaʻau. Ma kahi o 90% o ka hopena o ka hopena loa i mālama ʻia ma hope o nā pule ʻelua.

Mālama i nā hebedoma ʻehā e hoʻokō ai i ka hopena ma hope o ka mālama ʻia i ka wā o ka mālama ʻana i ka wā ma hope.

Ka hoʻokūkū piha plasma rosuvastatin ua hoʻomaopopo ʻia i ʻelima mau hola ma hope o ka lawe ʻana i ka pōpoki, ʻoi loa ka loaʻa ʻana o ka mākaukau bioavailability 20%.

Rosuvastatin ka nui nā ateʻo ke kumu nui o ke synthesizing kolamu a ka hoʻonoho ʻana kolamu lipoprotein haʻahaʻa haʻahaʻa.

ʻO ka laweʻana i ka waiwai e pili ana i ka 134 lita. Ma kahi o 90% rosuvastatin hoopaa i Nā protein protein (nui albumin).

Rosuvastatin ka hana 'ana i ka palena iki (ma kahi o 10%). I ka vitro e hoʻohana ai i ke kanaka hepatocytes noiʻi hoʻokūkū ua hōʻike ʻia nā mea ʻenekona wale nō hoʻokūkū iaa ʻōnaehana cytochrome P450. ^ E Ha yM. A hoʻokahi hoʻokūkū ʻaʻole hiki ke manaʻo ʻia he mea nui koʻikoʻi.

ʻO ka mea nui hikiwkomo i loko kaena ʻaila rosuvastatinʻo CYP 2C9. I kahi pae haʻahaʻa, komo lākou i ke kaʻina. hiki i nā mea kikowaena 2C19, 3A4 a me 2D6.

Ma ke kaʻina hana o ka metabolization, ʻelua nui hoʻonanea:

N-desmethyl hōʻike ʻia e ka hapa hapa o ka hana hoʻohālikelike ʻia rosuvastatin. ^ E Ha yM. E like me ka helu lactone, laila ua manaʻo ʻia he ʻano hana paʻa ʻole.

Rosuvastatin he oi aku ma kahi o 90% inhibitory hana e kū'ē ai hydroxymethylglutaryl-CoA reductase (HMG-CoA reductase), ka mea e kahe ana i ke kino kanaka i ke kahawai holoʻokoʻa.

ʻO nā mea nānā rosuvastatin (kahi kokoke i 90%) hōʻike ʻia i hoʻololi ʻole ʻia me nā ʻike nā ʻāpana. ^ E Ha yM. I kēia hihia, ua hoʻopili ʻia a paʻa ʻole i nā mea ikaika e hoʻopau ai.

O ke koenarosuvastatin neʻe i nā lā a me ka urine (ma kahi o 5% - i loli ʻole).

ʻO ka hapalua o ke ola o ka waiwai aia ma kahi o 20 mau hola a ʻaʻole ia e hilinaʻi i ka hoʻonui ʻana o ka lāʻau o ka lāʻau. Hoʻolaha ia mai ka pili koko ma kahi o 50 lita no hoʻokahi hola. ʻO ka loli ʻano e pili ana i ka nui o ka waiwai (coefficient of variation) he 21.7%.

Pēlā e like me nā lāʻau ʻē aʻe e pale ana i ka hana hydroxymethylglutaryl-CoA reductasehopu ia e ka puuwairosuvastatin hoʻolaha i ka komo ʻana o ka membpor transporter OATP-S, he mea nui i ka hana o ke neʻe ʻana i nā mea mai nā ate.

Rosuvastatin hōʻike ʻia e ka ʻōnaehana system-dependence, hoʻonui i ka pā i ka hoʻonui ʻana o ka nui o ka mea o ka mea.

ʻAʻole hoʻonā hou ka hoʻohana ʻana i ka lā lāʻau i ka hoʻonāukiuki i nā loli i loko o nā hiʻohiʻona pharmacokinetic o kāna ʻano hana.

ʻAʻole pili ka makahiki o ka mea maʻi a me ka wahine i ka pharmacokinetics o ka lāʻau. Ma ka manawa like, ua hōʻike nā noiʻi i loko o nā mea maʻi o ka lāhui Mongoloid, ka AUC a me ka nui o ka plasma koi rosuvastatin aneane ʻelua mau manawa e like me ke kiʻekiʻe o nā maʻi e pili ana i ka lāhui Caucasian.

He like nā hōʻailona o ka poʻe India no ke kiʻekiʻe o ka poʻe Caucasians ma kahi o 1.3 mau manawa. ʻAʻohe ʻanoʻokoʻa ʻē aʻe o ka maʻi i nā hōʻailona no nā ʻelele o ka lāhui Negroid a me Caucasians.

I nā maʻi me nā mālamalama maikaʻi ʻole i ka hoʻohaʻahaʻa a me ke ʻano maʻalahi, nā hōʻailona o nā koina kiʻekiʻe o ka rosuvastatin a N-desmethyl i ka plasma i loli iki.

I nā hiʻohiʻona koʻikoʻipilikia kūlohelohe hōʻailona o ke kaila plasma kiʻekiʻe rosuvastatin e ulu ma kahi o ʻekolu, a me ka hōʻailona o ke kaila plasma kiʻekiʻe N-desmethyl- he ʻeiwa mau manawa e hoʻohālikelike ai i nā hōʻailona i nānā ʻia i nā poʻe hana olakino olakino.

Nā kikowaena Plasma rosuvastatin i nā poʻe maʻi e hiki ana hemodialysisma kahi o ʻelua mau manawa iʻoi aku ma mua o nā mea hana ola olakino.

I pūpū hemama muli o ka maʻi pākī a ka lolo, nā hoʻoili ʻana o ka plasma rosuvastatin hoʻokiʻekiʻe ʻia

I ka poʻe maʻi e pili ana nā maʻi i ka papa A pēpē keiki pew, hōʻike i kahi o ka manaʻo kiʻekiʻe rosuvastatin i loko pili koko a ua hoʻonui ʻia ʻo AUC e 60 a me 5%, kēlā, ke hoʻohālikelike ʻia me nā mea maʻi, nui ka ate ke olakino.

Inā ka maʻi nā ate Nā loiloi i ka māhele B e pēpē keiki pew, nā mākaukau e hoʻonui i ka 100 a me 21%. No nā maʻi e pili ana ka maʻi i ka helu C, ʻaʻole ʻike nā ʻikepili, ka mea i hui pū ʻia me ka nele o ka ʻike me ka rosuvastatin no lākou.

Nā Hoʻohui

ʻO nā hoʻohālikelike i ke koho ʻana o nā papa ʻo Roxer e loaʻa ana i ka rosuvastatin ma nā kūlike e like me 5, 10 a me 15 mg nā:

ke hypersensitivity i hoʻokahi a keu aʻe paha o nā lāʻau.
nā ʻano hana nā puʻuwai naʻau (komo pū me nā maʻi o kahi ʻano maopopo ʻole o ka kumu), a me nā kūlana i hōʻike ʻia e ka piʻi mau ʻana transaminases hepatic, a me nā mea i loaʻa i kekahi o transaminases hepatic ʻaʻole e emi mai i lalo i ʻekolu manawa,
ʻōpala loloi ka hoʻomaʻemaʻe ʻana mea hana ʻaʻole i oi aku i ka nui o ka 30 ml / min,
hoʻoilina ʻōnaehana holomua maʻi neuromuscularhōʻike ʻia e ka nānā kumu kino nui (myopathies),
hoʻohana me kahi antidepressant Cyclosporin,
hopohopo ʻia me ka nui o ka ulu ʻana o ka hoʻolālā nā pilikia kikoo,
molololo lactose,
lactase hemahema,
glucose galactose glucose,
hapai (ʻoiai, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau no nā wāhine o ka hānau ʻana inā ʻaʻole i hoʻohana ʻia mea hoʻohālikelike),
hana waiū
makahiki i 18 makahiki.

Nā papa papa ʻōlelo rosuvastatin 30 a 40 mg mau mea i hoʻohālikelike ʻia:

nā mea maʻi me ka hypersensitivity i hoʻokahi a keu paha mau mea o ka lāʻau lapaʻau,
nā mea maʻi me nā palapala hoʻoikaika nā puʻuwai naʻau (komo pū me nā maʻi o kahi ʻano maopopo ʻole o ka kumu), a me nā kūlana i hōʻike ʻia e ka piʻi mau ʻana transaminases hepatic, a me nā mea i loaʻa i kekahi o transaminases hepatic ʻaʻole e emi mai i lalo i ʻekolu manawa,
ʻōpala loloi ka hoʻomaʻemaʻe ʻana mea hana ʻaʻole iʻoi aku ka kiʻekiʻe o 60 ml / min,
hoʻoilina ʻōnaehana holomua maʻi neuromuscularhōʻike ʻia e ka nānā kumu kino nui (myopathies),
hypothyroidism,
hoʻohana me kahi antidepressant Cyclosporin,
hopohopo ʻia me ka nui o ka ulu ʻana o ka hoʻolālā nā pilikia kikoo (ma ka mōʻaukala o ka mea maʻi aia kahi memo ma nā mānoʻi o ka hooweliweli i hoʻonā ʻia e kekahi lāʻau lapaʻau hou ʻia hydroxymethylglutaryl-CoA reductase a me ka mākaukau papaʻa waikawa fibroic),
mea inu wai inu
nā palapala kaumaha pūpū hema,
Laki Mongoloid
ka hoʻokipa like ʻana pāʻai,
molololo lactose,
lactase hemahema,
glucose galactose glucose,
hapai (ʻo ia hoʻi, ʻaʻole i kuhikuhi ʻia ka lāʻau lapaʻau no nā wāhine o ka hānau ʻana inā ʻaʻole lākou e hoʻohana i ka contraceptives).
hana waiū
makahiki a hiki i ke 18 a keu aku he 70 mau makahiki.

Nā hopena hopena

Hiki i nā hopena ʻokoʻa ke ola aʻe ma ka wā me ka maʻi me Roxeroy:

lue ka ka maʻi kūloheloheme ka hopena no ka hypersensitivity i rosuvastatin a i ʻole nā mea like o ka lāʻau lapaʻau, e komo pū ana angioedema,
lue nenoai, i hōʻike ʻia ma ke ʻano o ka constipation pinepine, ʻeha ma ka wahi o ka epigastric, hōʻeha, i nā hihia ʻehā hiki ke hoʻomohala lōkohu,
nā maʻi i hiki mai ma ka ʻaoʻao o ka ʻili a me nā ʻili a subutaneus a ke hōʻike ʻia nei ma ke ʻano o ka rashes ma ka ʻili, ka ʻeha o ka ʻili,urticaria,
ʻaʻano kūlā nūhou e hōʻike nei i ke ʻano myalgia (pinepine) a i kekahi manawa myopathies a rhabdomyolysis,
nā maʻi maʻamau, ka maʻi maʻamau ka mea maʻamau ʻaiaiaia,
lue ʻōpala a uria, ka mea pinepine e hoʻopili pinepine ʻia me ka piʻi ʻana o ke kōpaʻa o ka protein i ka urine.

Hiki i ka Roxer ke hoʻopilikia i ka loli ma o nā ʻāpana kaulike. No laila, ma hope o ka lawe ʻana i ka lāʻau, hoʻonui ka hana kinase kinasenā hōʻailona kuhikuhi kekuhi, bilirubinhoʻomoepūpū gamma glutamyl transpeptidases, Phakase alkaline, a me nā hōʻailona hoʻi o ka neʻe o ka plasma o nā loli e hoʻololi ai pani ʻia.

ʻO ke alapine a me ka paʻakikī o ka hopena o ka hopena e pili ana i ka hopena.

Nā papa ʻaʻa Roxer: nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana, ke ʻano o ka hoʻokele ʻana a me ka hoʻonui ʻia dosage

Ma mua o ke kuhikuhi ʻana i ka lāʻau lapaʻau, kuhikuhi ʻia ka mea maʻi e hoʻololi i kahi meaʻai maʻamau, ke kumu o ka hōʻemi ʻana i ke kiʻekiʻe o ka kolamu. ^ E Ha yM. Pili i kēia meaʻai pono a pono hoʻi i ka holo ʻana o ka mālama.

Koho ʻia ka makeʻe i kēlā me kēia e ka neʻe ʻana i ka kauka ma muli o ke kumu o ka lāʻau a me kona pono. Loaʻa ia e lawe i ka lāʻau lapaʻau i kēlā me kēia manawa o ka lā, ʻaʻole paʻa ʻia i ka manawa o ka ʻai ʻana.

Ua luku ʻia ka papa papaʻa ʻole, me kaʻole ʻole, me ka ʻole o ka ʻaʻā ʻana a me ka inu ʻana i ka nui o ka wai.

ʻO nā maʻi me hypercholesterolemia pono ʻoe e hoʻomaka i ka lāʻau lapaʻau me nā haʻalike like i ka 5 a i ʻole 10 mg rosuvastatin. ^ E Ha yM. Lawe ʻia nā papa pākuʻi hoʻokahi i kēlā me kēia lā. Eia kekahi, hoʻomau kēia kūlana no nā maʻi i mālama ʻole ʻia statins, a no nā poʻe maʻi i hōʻili ʻia ma ka mālama ʻana i nā lāʻau i hoʻopau i ka hana hydroxymethylglutaryl-CoA reductase.

I ka hoʻoholoʻana i ka hopena mua o Roxers, mālama pono ke kauka i nā hōʻailona kuhikuhi kolamu, a nānā pū i nā pōʻino i kūkulu ʻia nā hoʻopiʻi paʻakikī a me nā hopena maikaʻi.

I nā hihia e pono ai, hiki ke hoʻoponopono ʻia ke ʻano i ka pae e hiki mai ana, akā, i mālama ʻia kēlā ʻano hoʻololi i ʻole ma mua o 4 mau pule ma hope o ka koho mua ʻia ʻana.

Ka hāʻawi ʻana i nā hopena ʻino e pili ana i ka hana ma ke ʻano, a i ka wā e lawe ai i ka 40 mg o ka rosuvastatin e hana pinepine ʻia ma mua o ka lawe ʻana i loko o nā wahi liʻiliʻi, ʻoi aku ka hoʻonui ʻana i kēlā me kēia lā i 30 a 40 mg paha e mālama ʻia me ka mālama nui loa:

nā maʻi maʻi loa hypercholesterolemia,
nā mea maʻi e hoʻomohala hou i nā hoʻopiʻi mai ka hana mau naʻau a ʻōnaehana vascular (ʻokoʻa, inā ʻike ʻia ka mea maʻi familial hypercholesterolemia).

Inā e lawe i nā papa liʻiliʻi rosuvastatin ma kēia mau mahele o nā mea maʻi ʻaʻole i hāʻawi i ka hopena i manaʻo ʻia, ma hope o ka koho ʻana ʻo Roxers i kahi waihona o 30 a 40 mg paha i kēlā me kēia lā, pono mau ka poʻe maʻi ma lalo o ka mālama o ko lākou kauka.

Pēlā nō, hōʻike ʻia ka mālama ʻana ma nā maʻi maʻamau i nā manawa e hoʻomaka koke ai ka mālama ʻana me kahi maʻi o 30 a 40 mg.

E like me nā kuhikuhi i ka hoʻohana ʻana, ua hōʻike ʻia ʻo Roxer 20 mg ma ke ʻano he mua ʻana no ka hoʻopaʻa ʻana i nā maʻi mau naʻau a moku i nā maʻikahi mea i hoʻonui nui aʻe i ka hoʻomohala ʻana i nā ʻano hana like ʻole.

ʻO nā poʻe me ka hōʻemi haʻahaʻa o ka hana ʻōpala ʻaʻole koi ka hoʻoponopono ʻana, akā naʻe, ua kuhikuhi ʻia ka lāʻau lapaʻau me ka mālama ʻana i kēia pūʻulu o nā maʻi.

Ma ka hihia o ka hana hemahema ʻōpala loli i ka wā e hoʻomaʻemaʻe ʻia mea hana aia i loko o 60 ml / min, hoʻomaka me ka lapaʻau ma kahi maʻi o 5 mg. ʻO nā dosis kiʻekiʻe o ka lāʻau (30 a 40 mg) e contraindicated.

ʻO nā maʻi me nā maʻi hōʻeha ʻōpalakauoha ʻia ka lāʻau lapaʻau i kekahi hana i pāpā ʻia ʻia.

Ke koho ʻana iā roxers i nā maʻi me nā puʻuwai naʻau, nā hōʻailona o nā pēpē keiki pew ʻaʻole iʻoi aku i ka mea 7, ʻaʻohe mea e hoʻonui i ka hoʻolaha ʻana o nā ʻōnaehana rosuvastatin.

Inā loaʻa nā hōʻailona i ka hana lēʻaleʻa nā atee like me nā 8 a he 9 paha i loko pēpē keiki pew, hoʻonui ka hoʻonui i ka uila. No laila, ma mua o ke kuhikuhi ʻana i ka lāʻau i kēlā mau mea maʻi, e koi ʻia kahi noiʻi hou o ka hana. ʻōpala.

ʻO keʻike i ka mālama ʻana i nā maʻi maʻi nona nā hōʻailona ma mua o 9 mau waihona i loko pēpē keiki pewnalo nei.

Ke keu

Hōʻike ʻia nā hōʻike maʻi inā hiki ke hoʻonui ʻia ka nui o ka lāʻau lapaʻau ma o ka nui o ka lāʻau lapaʻau. Ma hope o hoʻokahi kahe o ka Roxer i loko o kekahi mau manawa ʻoi aku ka nui ma mua o nā lā i hoʻokumu ʻia i kēlā me kēia lā, nā loli koʻikoʻi i loko o ka pharmacokinetics rosuvastatin ʻaʻole i hōʻike ʻia.

I ka hihia o ka overdose a me nā mea e hiki mai nā hōʻailona o ka hoʻokomo hōʻike ke kino i ka hanana hōʻailona a, inā pono, ʻo ka koho ʻana i kahi pae kākoʻo.

Hoʻoikaika ʻia ka mālama ʻana i nā hana. kinase kinase a ke hana nei i kahi hoʻokolohua e loiloi i ka hana ʻana nā ate.

Ke kūlike i ka koho hemodialysis ua manao ʻole.

Hoʻohui

Ma ke koho ʻana iā Roxers i hui pū me Cyclosporine ua hoʻonui nui AUC rosuvastatin (kokoke i ʻehiku mau manawa), ʻoiai ke kukuna o ka plasma piipili ʻaʻole i loli mau.

Me ka hoʻokolohua ʻōpiopio me nā lāʻau antagonist waiora K a i ʻole ke hōʻola ʻana i nā lāʻau hydroxymethylglutaryl-CoA reductase, ma ka hoʻomaka ʻana o ka papa o ka mālama ʻana, me ka hoʻonui pū ʻana i ka lā maʻamau i kēlā me kēia lā i kona titration, he ʻano nui i loko o INR (ʻo ke ʻano maʻamau o ka maʻamau).

E like me ke kānāwai, e kū'ē ana i ke kaona o ka hōʻemi ʻemi ʻana i ka wili a i ʻole ka hoʻoneʻe ʻana i ka lāʻau lapaʻau.

Hoʻohana like me kahi lipid-e hoʻohaʻahaʻa i ka lāʻau Ezetimibe ʻaʻole ia e hoʻonāukiuki i nā loli i ka AUC a me ke koʻo o ka plasma kiʻekiʻe o nā ʻano ʻelua, akā naʻe, ʻaʻole i haʻalele ʻia ka hopena o ka pharmacodynamic.

E hui pū me Gemfibrozil a me nā lāʻau ʻē aʻe e kōkua ana e hōʻemi i nā pae Nā lipopōhoʻonāukiuki i ka nui o ka pālua i ka AUC a me ka nānā ʻana o ka plasma kiʻekiʻe rosuvastatin.

Ua hōʻike ʻia nā haʻawina kūikawā i kēlā hoʻokolokolo me Fenofibrate hiki ole i kekahi ke aloha aku i kahi loli i loko o nā laikini pharmacokinetic, eia naʻe, ʻaʻole i haʻalele ʻia ka maikaʻi loa o ka lāʻau lapaʻau me ka lāʻau lapaʻau.

Pākuʻi hua lāʻau Hemfibrozil a Fenofibratea me ke ano laau hoʻōla nicotinic, ʻoiai ko lākou koho me nā inhibitors hydroxymethylglutaryl-CoA reductase hoʻonui i ka loli myopathies (ʻo, ʻoi paha, ma muli o kā lākou hiki ke hoʻonāukiuki i ka hopena like i ka wā i kuhikuhi ʻia ai lākou he monotherapeutic agent).

Me ka hoʻohana ʻana o Roxers me nā huaʻai, rosuvastatin ʻaʻole i kuhikuhi ʻia nā papa i 30 a 40 mg. Initial i kēlā me kēia lā rosuvastatin no nā mea maʻi e lawe nei nā huaʻaihe 5 mg.

Hoʻohana pinepine i ka lāʻau me nā inhibitors Serineprotease hoʻonāukiuki i kahi loli rosuvastatin. ^ E Ha yM. No kēia kumu, ʻaʻole kuhikuhi ʻia ʻo Roxer. Maʻi HIV-infected nā maʻi e hana nei i ka mālama ʻana me nā lāʻau mālama inhibitor ʻO nā proteine serine.

ʻOiai e lawe pū ana me antacid Hoʻomākaukau hoʻomākaukau rosuvastatinua hoemiia e ka hapalua. E hōʻemi i ka paʻakikī o kēia hopenaantacids Manaʻo ʻia e lawe i ʻelua mau hola ma hope o ka lawe ʻana i nā papa Roxer.

E kūʻē i ke kua o ke kau wā i koho ʻia ai rosuvastatin me Erythromycin AUC helu rosuvastatin e emi ana i ka 20%, a me kona kukuna papa ʻōlelo i ka hapakolu. Hiki paha kēia i ka hoʻonui ʻia o ka hoʻoweliweli. wahīkahi e hoʻonāukiuki ai Erythromycin.

Me ke koho ʻana o Roxers i hui pū me ka contraceptives hormonal no ka hoʻoponopono waha, nā māka AUC Ethinyl estradiol hoʻonui i ka 26%, a me ka hōʻailona like no norgestrel - e 34%.

Pono e nānā i kēia mau pae ma AUC i ka wā e koho ai i ka momona kūpono. ʻāponono ka lawelawe waha.

ʻAʻohe data data pharmacokinetic e pili ana i ka hoʻohana ʻana me nā lāʻau lapaʻau no ka hoʻonaninani ʻana i ke ʻano o ka hormone, akā naʻe, ʻaʻole i waiho ʻia ka hopena o ka hoʻopili ʻana a i hoʻonui ʻia ʻo AUC.

ʻO nā haʻawina o ka hui pū ʻana o rosuvastatin me kahi pacemaker Digoxin ʻaʻole i hōʻike i kahi hoʻokūkū koʻikoʻi.

Rosuvastatin ʻAʻole ia he hopena luhi a ʻaʻole i hoʻoulu ʻia hiki i nā mea kikowaena ʻōnaehana helei Htoi P450. ^ E Ha yM. ʻO ka mea'ē aʻe, metabolization rosuvastatin ma lalo o kā lākou mana he liʻiliʻi a ʻaʻole koʻikoʻi ke koʻikoʻi.

Kekahi pilina pili waena rosuvastatin a me nā hui antifungal Fluconazole a Ketoconazoleka mea e pale ai i ka hana o nā isoenzymes cytochrome i hōʻike ʻole ʻia.

E hui pū me ka lāʻau antifungal Intraconazole, ka mea e pale ai i ka hana hikiw Hōʻike ka CYP 3A4 i ka hoʻonui ʻana i ka AUC o ka rosuvastatin ma ka 28%. Eia naʻe, ʻaʻole e noʻonoʻo ʻia ka hoʻonui ʻia ʻana o ka maʻi nui.

Lapaʻau lāʻau

ʻO ka manawa e hiki ai i ka plasma kiʻekiʻe loa (Cmax) o ka rosuvastatin i loko o ke koko ma hope o ka lawelawe waha ma kahi o 5 mau hola. Bioavailability piha o kahi mea

20% ʻO ka metabolabol ka hana nui ma ka ate. ʻO ka nui o ka hoʻolaha e like me 134 lita. ʻO ka hapa nui o nā mea (he 90%) e nakinaki ai i nā protein plasma, ʻo ka mea nui me ka albumin.

Rosuvastatin e hana i ka palena metabolism (

10%). No ka helu ka mea i nā landina o nā kikoʻī ʻole o ka cytochrome P450. ʻO ka isoenzyme nui i hoʻokomo i kona metabolism ʻo ka isoenzyme CYP2C9. Hoʻokomo ka hoʻokomo i ka metabolism o nā isoenzymes CYP2C19, CYP3A4, CYP2D6 i kahi ka liʻiliʻi. ʻO nā metabolites nui i ʻike ʻia ʻo N-desmethylrosuvastatin (ʻoi aku ka hana o ka manawa 2 mau haʻahaʻa ma lalo o ka rosuvastatin) a me nā metabolite lactone (ʻaʻohe hana lāʻau lapaʻau). Hāʻawi ʻia ka hana ʻoihana lāʻau lapaʻau no ka pale ʻana i ka plasma HMG-CoA reductase ma muli o ka rosuvastatin (ʻoi aku ma mua o 90%).

Ma kahi o 90% o nā mea e hoʻoneʻe ʻia ma ka ʻōpū o ka pahu i loli ʻole (komo pū ʻole ʻia / ʻauamo rosuvastatin), ke koena - e nā kuli. ʻO ka hapalua-ola o kahi mea mai loko o ke kaila koko ma kahi o 19 mau hola (ke hoʻonui ʻana i ka nui ʻaʻole i pili i kēia hōʻailona). ʻO ka hoʻonaninani kaila geometric ʻo 50 l / h (me ka coefficient o kekahi ʻano - 21.7%).

Me ka loaʻa o kēlā me kēia lā, ʻaʻole i mālama ʻia nā loli i nā ʻōkuhi pharmacokinetic. Hoʻopau ka ʻōhumu o nā ʻōnaehana i ka hoʻohālikelike i ka nui.

Wahi a nā haʻawina ʻo pharmacokinetic, i ka poʻe maʻi o ka lāhui Mongoloid (Kepani, Pilipino, Kina, Koreans a Vietnamese), ke median AUC a me ka nui o ka piʻi ʻana o ka rosuvastatin e pili ana i ka 2 mau manawa e hoʻohālikelike ai me ka lāhui Caucasoid, no nā India ka mea e ʻoi ai ka hoʻonui nui ʻana ma ka ʻAhia AUC a me Cmax he 1.3.

I nā mea maʻi me ka cleince clearance (CC) ma mua o 30 ml / min, ke piʻi ʻana o ka plasma o rosuvastatin a me N-desmethylrosuvastatin i ke koko me ka nui o ka ulu.

I ka maʻi maʻamau o ka palaka palaka ʻana, e piʻi iki ka plasma o ka rosuvastatin e loli ana i ka nui. Ke hoʻohālikelike nei: nā maʻi me ka hana o ka puʻuwai maʻamau / nā mea maʻi me ka hana ole o ka maʻi (e like me ke ʻano o ke keiki-Pugh: 7 a i ʻole nā helu haʻahaʻa / 8-9 poʻe) AUC a me Cmax o ka rosuvastatin i hoʻonui ʻia e 5 a 60% / 21 a 100%, ma kēlā. ʻO ka ʻike me nā rosuvastatin i nā maʻi me ka hōʻoki ʻana o ka ate ma mua o 9 mau hala.

Ka hoʻonohonoho ʻana a me ke ʻano o ka hoʻokuʻu ʻana

Loaʻa ka lāʻau lapaʻau Roxer i ka palapala papa no ka hoʻokūkū waha (hoʻokele waha). Hōʻalo ʻia nā papa me ke kāwele kiʻi keʻokeʻo. ʻO ka pōʻai, biconvex me kahi bevel, ma ka ʻaoʻao hoʻokahi e hōʻailona ana "10", hoʻopaʻa ʻia. ʻO ka mea kumu nui o ka lāʻau ʻo rosuvastatin. ʻO kona mea i loko o kahi papa hoʻokahi he 10 mg. Hoʻokomo pū ʻia nā mea hoihoi, kahi;

Macrogol 6000.
Methyl methacrylate copolymer.
ʻO ka cellulose Microcrystalline.
ʻO ke kinikini silica colloidal.
Kaapili Titanium
Kūʻaiole.
Lawaʻawa Lactose.
ʻO ka lāʻau ʻo Magnesium.

Hoʻopaʻa ʻia nā papa Roxer i loko o kahi pūʻulu blister o 10 mau ʻāpana. Aia ka pahu kīleʻa he 3 a 9 mau kapa paha a me nā ʻōlelo no ka hoʻohana ʻana i ka lāʻau lapaʻau.

ʻO nā waiwai Pharmacological

ʻO ka hana kumu nui o nā papa Roxer ʻo rosuvastatin, he pololi i ka hana o ka enzym HMG-CoA reductase, nona ke kāpili ʻana o ka mua o ka mevalonate cholesterol. Hana ia i nā kōpona ate, nona ke kuleana no ka syntetika o endogenous (nona iho), ma muli o kona pae i ke koko. Eia kekahi, kū i ka ʻikepili o ka hoʻohana ʻana i ka lāʻau, hōʻemi ka nui o ka lipoproteins density haʻahaʻa a haʻahaʻa loa (hāʻawi i ka hoʻohemo ʻana o kolamu ma nā paia o nā arteri) a me ka piʻi ʻana o ka nui o ka lipoproteins kiʻekiʻe (e hōʻemi ana i ka nui o ke kaʻina o ka haʻalele ʻana o ka kolamu i nā pā o nā ʻili).

Ma hope o ka lawe ʻana i nā papa o Roxer i loko, ua wikiwiki ka papa mea kūpono, akā ʻaʻole paʻa i loko o ke koko. Me ke kahe o ke koko, ke komo ia i nā pūpū palapela (hepatocytes), kahi ia he hopena therapeutic. ʻAʻole hoʻohuli ʻia ka Rosuvastatin a hoʻōla ʻia i ka maʻamau me nā feces.

ʻLoe a me ke kākele

I loko, pono e hoʻokaʻawale ʻia a papaʻa paha ka papa papa, ʻū ʻia piha, holoi ʻia me ka wai, hiki ke lawe ʻia i kēlā me kēia manawa o ka lā, me ka ʻano o ka manawa ʻaina. Ma mua o ka hoʻomaka ʻana i ka maʻi me Roxer, pono e hoʻomaka ka mea maʻi e hahai i ka maʻamau hypocholesterolemic diet a hoʻomau ma muli o ia i ka wā o ka mālama ʻana. Pono ke koho o ka lāʻau lapaʻau e koho kuʻuna i ka pahuhō o nā pahuhopu a me ka pane ʻana i ka therapeutic i ka mālama ʻana, i ka nānā ʻana i nā ʻōlelo ʻōiwi o ka nūnū i nā mea pili i ka lipid plasma. ʻO ka papa hana i hoʻomaka ʻia no nā maʻi e hoʻomaka ana e lawe i ka lāʻau lapaʻau, ai ʻole no nā mea maʻi i hoʻihoʻi mai i ka lawe ʻana i nā HMG-CoA reductase inhibitors, pono ʻo 5 paha 10 mg mau lāʻau o Roxer i ka manawa i ka lā.

Me ka hoʻohana like ʻana o ka lāʻau lapaʻau me ka gemfibrozil, fibrates, ka waikika nicotinic i nā lipid e hoʻohaʻahaʻa i nā wai (ʻoi aku ma mua o 1 g / lā), nā mea maʻi e hoʻolako ʻia i kahi hoʻomaka mua o ka lāʻau 5 mg / lā. Ke koho ʻana i kahi pualikoa mua, pono alakaʻi ʻia e kekahi o ka plasma cholesterol kanaka ponoʻī a e noʻonoʻo i ka hiki pono ʻana i ke ʻano o ka hoʻomohala ʻana i nā hoʻopiʻi cardiovascular, a ʻoi paha ka hopena o ka hopena o ka hopena i mea e ʻike ʻia. Inā kūpono, e hoʻonui ʻia ka pākeke ma hope o nā 4 hebedoma.

Ma muli o ka hiki ke hoʻomohala ʻia o nā hopena hopena inā ke noi ʻana i kahi maʻi o 40 mg / lā, i hoʻohālikelike ʻia me nā haʻahaʻa haʻahaʻa o ka lāʻau, ke hoʻonui nei i ka nui i ka pae o 40 mg / lā pono e noʻonoʻo wale i nā mea maʻi me ka maʻi nui o hypercholesterolemia a me ka makeʻe kiʻekiʻe o ka hoʻomohala ʻana i nā hoʻopiʻi cardiovascular ( ʻoi loa i nā mea maʻi me ka hypercholesterolemia familial) ʻaʻole i hoʻokō i ka hopena i makemake ʻia o ka therapy me kahi maʻi o 20 mg / lā, a ʻo ia ka mea i lalo o ka mālama o kekahi kauka. ʻAno ʻia ka nānā ʻana i nā maʻi e loaʻa ai ka lāʻau lapaʻau ma kahi maʻa o 40 mg / lā i hāpai ʻia.

ʻO ka hoʻohana ʻana i kahi maʻa o 40 mg / lā i nā maʻi i nīnau ʻole ʻia ma mua i kahi kauka. Ma hope o 2 mau hebedoma o ka lapaʻau a me / a me ke kiʻi ʻana o ka nui o ka lāʻau o ka lāʻau Roxer, pono ka nānā ʻana o ka metabolism lipid (pono ʻia ke hoʻoponopono ʻia inā pono).

ʻO nā mea maʻi me ka maikaʻi ʻole o ka pūpū

I nā mea maʻi me ka hōʻemi ʻole ʻana a me ka hoʻololi ʻole, ʻaʻole i koi ʻia ka hoʻoponopono ʻana. I ka poʻe maʻi me ka hikiʻole o ka pilikia renal (CC ma mua o 30 ml / min), ua hoʻohana ʻia ka hoʻohana ʻana o Roxer. ʻO ka hoʻohana ʻana o Roxer ma kahi maʻi ʻoi aku ma mua o 30 mg / lā ua contraindicated i loko o nā mea maʻi me ka hōʻemi a i ʻole pilikia nui (CC ma mua o 60 ml / min). No nā mea maʻi me ka hikiʻole o ka renal moderate, ʻo ka ʻōlelo hoʻomaka ʻana o ka Roxer o 5 mg / lā.

Hoʻohana i ka wā hāpai a me ka umauma

ʻO ka lāʻau lapaʻau o Roxer e contraindicated ma ka hāpai a me ka lactation.

Pono nā wahine o nā makahiki hānau hānau i nā ala kūpono o ka contraception.

I ka hihia o ka hāpai ʻana i ka wā e hoʻōla ai, e hoʻopau koke ka hoʻohana ʻana i ka lāʻau.

Hola paʻa kino hana

I loko o nā mea maʻi e loaʻa ana i nā koina nui o ka rosuvastatin (ma loko mau o 40 mg / lā), ua ʻike ʻia ka tubula proteinuria, ka mea i ʻike ʻia me ka hoʻohana ʻana i nā kānana hōʻike, a ma ka hapanui o ia mau wā, he wā wā wā pōkole paha ʻAʻole hōʻike ʻia kēlā proturia i ka maʻa a i ʻole ka hoʻomau ʻana o ka maʻi ʻōnaehana concomitant. ʻO ka pinepine o ka pilikia o ka renal koʻikoʻi i hōʻike ʻia ma ka hoʻopaʻa ʻana ma hope o ka noi ʻana o rosuvastatin i ke kiʻekiʻe me ka nui o 40 mg / lā. I nā mea maʻi e lawe ana i ka lāʻau lapaʻau Roxer ma kahi lāʻau o 30 a 40 mg / lā, pono ʻia e nānā i nā ʻōnaehana hana luhi ma ka wā o ka mālama ʻana (ma kahi o 1 mau manawa ma 3 mau mahina).

Hoʻopilikia i ka ʻōnaehana musculoskeletal

Ke hoʻohana nei i ka rosuvastatin i nā āpau āpau, akā inā he keu ma mua o 20 mg / lā, ua hōʻike ʻia nā hopena e pili ana i ka ʻōnaehana musculoskeletal: myalgia, myopathy, i nā hihia loaʻa, rhabdomyolysis. Nui mau hihia nā rhabdomyolysis i ʻike ʻia me ka hoʻohana pū ʻia ʻana o HMG-CoA reductase a me nā mea hoʻoneʻe ezetimibe. Pono e hui pū ʻia me kēlā me kēia akahele, no ka mea, ʻaʻole e hiki ke hoʻokele ʻia ka launa ʻo ka pharmacodynamic. E like me ka poʻe ʻē aʻe HMG-CoA reductase inhibitors, ʻo ka nui o ka rhabdomyolysis ma ke hoʻohana ʻana i ka hoʻohana ʻana o ka lāʻau maʻi Roxer e kiʻekiʻe loa ana ke kiʻekiʻe inā ka make i ka 40 mg / lā.

Ka hoʻoholo ʻana o ka hana CPK

ʻAʻole hiki ke hoʻoholo ʻia ka hana CPK ma hope o ka hoʻoikaika kino ʻana a i ka manawa ʻē aʻe o nā kumu ʻē aʻe e hoʻonui ai i kāna hana, hiki i kēia ke hana i kahi wehewehe maikaʻi ʻole o nā hopena. Inā hoʻonui ʻia ka hana mua o ka CPK (5 mau manawa kiʻekiʻe ma mua o ka palena o ka maʻamau), pono e hana ʻia kahi hana ma hope o nā lā 5-7. ʻAʻole hiki iā ʻoe ke hoʻomaka i ka hoʻōla inā loaʻa nā hopena o ka reanalysis i ka hana KFK kiʻekiʻe (ʻoi aku ma mua o 5-piʻu ka nui o ka palena o ka maʻamau).

Ma mua o ka hoʻomaka ʻana i kahi lapaʻau

Wahi a ka pā i kēlā me kēia lā, pono ke kuhikuhi ʻia ka lāʻau o Roxer me ka makaʻala ʻana i nā poʻe maʻi me nā mea pili i ke ala no ka myopathy / rhabdomyolysis, a i ʻole hoʻohana ʻia o ka lāʻau e contraindicated (e ʻike i nā ʻāpana "Contraindications" a me "Caution").

ʻO kēia mau mea penei:

huakaʻi renal function,
hypothyroidism
ka mōʻaukala o nā maʻi ʻeha (ʻo ka mōʻaukala ʻohana),
nā hopena myotoxic i ka wā e lawe ai i nā inhibitors HMG-CoA reductase inhibitors a hoʻohālikelike ʻia i ka mōʻaukala,
inu nui
ma mua o 65 mau makahiki
mau kūlana e hoʻonui ai ke kahe ʻana o ka rosuvastatin i loko o ke koko koko,
ka manawa like ʻole o nā fibrates.

I kēlā mau maʻi maʻi, he mea pono e loiloi i ka pale a me nā pono kūpono o ka lāʻau. Hoʻoikaika ʻia ke nānā ʻana i nā maʻi maʻi. Inā ʻoi aku ka ʻoihana mua o ka CPK ma mua o 5 mau manawa i ʻoi aku ma mua o ka palena o ka maʻamau, pono e hoʻomaka ʻia ka lāʻau me Roxer.

I ka wā o ka mālama ʻana me ka lāʻau lapaʻau

E hoʻomaopopo ʻia ka mea maʻi i ka pono o ka nānā ʻana i nā lāʻau lapaʻau koke inā he hoʻomaka koke ka hōʻeha ʻana o ka ʻeha o ka naʻau, nā ʻōpū palupalu a i ʻole ka hoʻopiʻi ʻana, ka pūlima me ka maʻi mele a me ke kuni. I kēlā mau mea maʻi, pono e hoʻoholo ʻia ka hana CPK. Pono e hoʻokuʻu i ka lāʻau inā hoʻonui ʻia ka hana o ka CPK (ʻoi aku ka 5 mau manawa e hoʻohālikelike ʻia me ka palena palena o ka maʻamau) a inā i ʻōlelo ʻia nā hōʻailona o ka ʻāʻī a hoʻolilo i nā pilikia o kēlā me kēia lā (ʻoiai inā ʻaʻole ʻoi aku ka hana o ka CPK ma mua o 5 mau manawa o ka palena luna ʻokoʻa) Inā lilo nā hōʻailona a hoʻi hou ka hana CPK, pono e noʻonoʻo e noʻonoʻo i ka hoʻohana ʻana o Roxer a i ʻole ko HMG-CoA reductase inhibitors i nā haʻahaʻa haʻahaʻa me ka mālama mālama olakino maikaʻi. ʻO ka nānā ʻana i ka hana o CPK i ka haʻalele ʻana o nā hōʻailona kūpono ʻole. ʻO nā hihia koʻikoʻi ʻoi aku ka pale ʻana i ka meopathy me ka pale ʻana i ka lapaʻau ʻia ma ke ʻano o ka hoʻomaloka ʻana o ka ʻoi ʻana o ka musna proximal a me ka hoʻonui ʻana o ka hana CPK serum i ka wā o ka mālama ʻana a i ka wā e hoʻohiolo ai i ka hoʻohana ʻana o ka hoʻōla ʻia o HMG-CoA, me ka rosuvastatin, i ʻike ʻia. Pono nā haʻawina hou o ka ʻiʻo a me ka hoʻonaninani, nā noi ʻana serological, a me ke ʻano immunosuppressive paha e pono ai.

ʻAʻohe hōʻailona i hoʻonui ʻia i ka hopena o ka mākeke mākeke i ka wā e lawe ai i ka lāʻau rosuvastatin a me ka concomitant therapy. Eia naʻe, he hoʻonui nui aʻe o ka ulu ʻana o ka myositis a me myopathy i hōʻike ʻia i nā mea maʻi i lawe i nā poʻe ʻē aʻe HMG-CoA reductase inhibitors i hui pū me nā fibivic acid derivatives (e.g. gemfibrozil), cyclosporine, acid nikotinic ma lipid hoʻohaʻahaʻa i nā dosis (ʻoi aku ma mua o 1 g / lā), nā derivatives antifungal. azole, HIV protease inhibitors a me macrolide antibiotics.

I ka manawa i hoʻohana ʻia me kekahi mau HMG-CoA reductase inhibitors, ʻo gemfibrozil e hoʻonui i ka nui o ka myopathy. No laila, ʻaʻole i ʻōlelo ʻia ka hoʻohana like o ka lāʻau Roxer a me gemfibrozil. ʻO nā pono o ka hoʻololi hou ʻana i ka plasma plasma o ka lipid me ka hoʻohana pū ʻana o Roxer me nā fibrates a i ʻole ka nicotinic acid i loko o ka lipid e hoʻohaʻahaʻa i nā ʻōmole e nānā pono i ke ʻano o ka hopena hiki. ʻO ka lāʻau Roxer i kahi maʻa o 30 mg / lā e contraindicated no ka hui pū ʻana me nā fibrates. Ma muli o ka hoʻonui nui o ka rhabdomyolysis, ʻaʻole hiki ke hoʻohana ʻo Roxer i nā mea maʻi me nā maʻi kūlohelohe hiki ke alakaʻi i ka myopathy a i ʻole nā kūlana e manaʻo mua nei i ka hoʻomohala ʻana o ka pilikia o ka hakahaka (me ka laʻana, sepsis, hypotension arterial, ka nui hoʻopiha, trauma, metabolic koʻikoʻi, endocrine a me nā electrolyte haunaele a i ʻole a hoʻokapu ʻole ʻia.

Pilikia ka pehu

Wahi a ka pālākiō i kēlā me kēia lā, pono e hoʻohana ʻo Roxer me ka makaʻala i ka poʻe maʻi me ka inu ʻawaʻawa nui a me / a i ʻole kahi moʻolelo o nā maʻi o ka pūpū a i ʻole kona hoʻohana ʻana he contraindicated (e ʻike i nā ʻāpana "Contraindications" a me "Caution").

A hoʻoholo ʻia e hoʻoholo i nā hoʻokolohua o ka hana o ka ate ma mua o ka hoʻomaka ʻana o ka lāʻau a me 3 mau mahina ma hope o kona hoʻomaka. Pono e hoʻohana ʻia ka hoʻohana ʻana o ka lāʻau Roxer a i ʻole pono e hōʻemi ʻia ka hopena o ka lāʻau inā he hana ka melamin o ka "ati" i loko o ka serum koko he 3 mau manawa kiʻekiʻe ma mua o ka palena o luna.

I ka poʻe maʻi me ka hypercholesterolemia ma muli o ka hypothyroidism a iʻole nephrotic syndrome, e pono e lawe i ka lāʻau o nā maʻi lalo ma mua o ka mālama ʻana me Roxer.

Pākuʻi helu

ʻO nā papa papa kiʻi 5 mg, 10 mg, 20 mg a me 40 mg

Aia ma ka papa papa

mea waiwai - ke kīhi rosuvastatin 5.21 mg, 10.42 mg, 20.83 mg, a i ka 41.66 mg (like me 5 mg rosuvastatin, 10 mg, 20 mg a 40 mg, kēlā me kēia),

i lokonā mea hoʻohālikelike: cellulose microcrystalline, anhiddrous lactose, crospovidone, silicon dioxide, colloidal anhydrous, magnesium stearate,

sheath film: ka copolymer kumu nui o ka methacrylate i hoʻohui ʻia, macrogol 6000, titanium dioxide E171, lactose monohydrate.

Hoʻokomo ʻia nā papa ʻula ma kahi ʻano, me kahi pā anuʻu biconvex, i kāʻei ʻia me kahi uhi kiʻi keʻokeʻo, hōʻailona ʻia i "5" ma kahi ʻaoʻao a me kahi bevel (no ke ʻano o 5 mg).

Hoʻokomo ʻia nā papa ʻula ma kahi ʻano, me kahi pā anuʻu biconvex, i kāʻei ʻia me kahi uhi kiʻi keʻokeʻo, hōʻailona ʻia “10” ma kahi ʻaoʻao a beveled (no kahi ana o 10 mg).

Nā ʻāpana lapalapa, i ulana ʻia me ke kāʻei kiʻi keʻokeʻo, me kahi bevel (no ke ʻano o 20 mg).

ʻO nā papa i kālai ʻia me nā pahu biconvex, i kālai ʻia me kahi kāʻei kiʻi keʻokeʻo (no ka dosage o 40 mg).

ʻLoe a me ke kākele

Ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau, pono ka mea maʻi ma luna o ka meaʻai maʻamau me ka haʻahaʻa haʻahaʻa a hoʻomau i ka hoʻokau ʻana i kēia meaʻai i ka wā mālama. Hoʻonohonoho ʻia ka nui o ka lāʻau lapaʻau kū hoʻokahi, e pili ana i nā pahuhopu o ka lāʻau, ka pane a ka mea maʻi i ka mālama ʻana. ʻO ka paona hoʻomaka i kēlā me kēia lā mai 5 mg a 10 mg a lawe ʻia i hoʻokahi lā i kēlā lā. Hoʻolā ka like o ka maʻi no nā poʻe maʻi e lawe nei i nā statins no ka manawa mua, a ke hele nei paha mai ka maʻi mai me kahi HMG inhibitor, CoA reductase. Ke koho nei i kahi hoʻomaka hoʻomaka, pono ia e noʻonoʻo i ka pae pākēneka o nā kānaka pākahi a me ka loaʻa o ka puʻuwai cardiovascular, a me ke ʻano o ka hopena e hiki ai ke hoʻomohala i ka hopena.

Inā makemake, hiki ke hoʻonui ʻia i ka minamina ma hope o 4 hebedoma. Hāʻawi i ka hoʻonui pinepine ʻia o nā hōʻike o ka hana ʻino i ka wā e lawe ai i ka nui o 40 mg ka hoʻohālikelike ʻia me nā haʻahaʻa haʻahaʻa, ʻoi ka hoʻonui ʻana o ka pāhana i kēlā lā i kēia lā he 30 mg a 40 mg paha e noʻonoʻo wale ʻia nā mea maʻi me ka hyperlipidemia koʻikoʻi a me ka hopena cardiovascular kiʻekiʻe (ma ke ʻano, me ka hypercholesterolemia familial) , kahi hiki ʻole ke hoʻokō i nā pae lipid target i ka wā e lawe ai i nā papa haʻahaʻa, a e nānā ʻia ai. Pono e nānā pono i nā poʻe maʻi i ka wā e hoʻomaka ai lākou e lawe i nā kaila o 40 mg a 30 mg.

ʻO ka hoʻonui ʻia o ka nui i ka 40 mg hiki ke aia wale ma lalo o ka mākaʻi o kahi kauka. ʻAʻole kōkua ʻia kahi pākēneka o 40 mg no nā maʻi i lawe ʻole i ka lāʻau. Ma hope o 2 mau wiki o ka lapaʻau a me / a me ke kiʻi ʻana o ka nui o ka make o Roxer, pono ka nānā ʻana o ka metabolile lipid (inā pono, hoʻoponopono hoʻoponopono ʻia).

Hiki ke kiʻi ʻia ʻo Roxera® i kēlā me kēia manawa o ka lā, ʻaʻohe mea o ka meaʻai.

Hoʻohana ma ka pākeke

Hoʻomaopopo ʻia nā mea maʻi ma luna o ka makahiki he 70 e hoʻomaka e lawe i ka lāʻau lapaʻau me kahi hapa o 5 mg

ʻO ka maʻi ma nā maʻi me nā pilikia ʻole

I nā mea maʻi me ka hōʻemi ʻole ʻana a me ka hoʻololi ʻole, ʻaʻole i koi ʻia ka hoʻoponopono ʻana, ʻo ka lāʻau i hoʻomaka ʻia i mua o ka lāʻau no 5 mg. I ka poʻe maʻi me ka hana renal moderate huakaʻi (ʻo ka cleinine clearance ma mua o 60 ml / min) - ke hoʻohana nei i ka lāʻau lapaʻau i loko o kahi waihona ʻaiʻo 40 mg. I nā mea maʻi me ka maikaʻi o ka renal maikaʻi ʻole (ʻo ka clearanine clearance ma mua o 30 ml / min), ua hoʻohana ʻia ka hoʻohana ʻana o Roxer®.

ʻO nā maʻi ma nā maʻi me nā hōʻeha pale

I nā maʻi me 7 a i ʻole nā haʻahaʻa keiki-Pugh, ʻaʻole pono ka hoʻoponopono ʻana. ʻAʻoheʻike me ka hoʻohana o ka lāʻau lapaʻau i nā mea maʻi me ka helu ʻoi aʻe ʻoi aʻe ma mua o ka 9 ma ke kiʻekiʻe Child-Pugh.

Ua hoʻohālikelike ʻia ʻo Roxer® i nā mea maʻi me ka maʻi pūpū ikaika.

Ua hoʻonui ʻia ka hoʻonui ʻia ʻana o ka mālama ʻana i ka rosuvastatin ma waena o Iapana a me Kina. ʻO ka ʻōmato hoʻomaka e hoʻomaka ʻia no nā maʻi maʻi ʻAsia 5 mg. ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau ma kahi mahele o 30 mg a 40 mg paha ua hoʻohālikelike ʻia i nā mea maʻi o ka lāhui ʻAiwi.

Ke hana nei i nā maʻi me nā predisposition i ka myopathy

ʻO ka papa hoʻomaka ʻana i nā maʻi me nā mea e ʻike ʻia i ka hoʻomohala ʻana o ka myopathy ʻo 5 mg. ʻO nā dosis o 40 mg a me 30 mg ka contraindicated ma kēlā mau maʻi.