Ke kinipōpō Astrozone: nā ʻōlelo no ka hoʻohana ʻana

Loaʻa ka lāʻau lapaʻau i ke ʻano o nā papa. ʻO ka waiwai koʻikoʻi ka pioglitazone ma loko o kahi waihona no 30 mg. Nā kumuwaiwai hou e kū nei: lactose, magnesium stearate, hyprolose, sodium croscarmellose.

Hoʻokomo ʻia nā papa i loko o nā pūʻulu blister o 10 mau ʻāpana.

I ka 1 pēpē kāleka hiki iā 3 a 6 paha o kēia mau paʻi. Eia kekahi, hiki ke loaʻa i ka lāʻau lapaʻau nā kalima polymer (30 mau papa i kēlā me kēia) a me nā hue like ʻole (30 mau ʻāpana).

Ka hana lāʻau lapaʻau

Hoʻololiʻi ʻo Clinical microbiology i kēia lāʻau lapaʻau me nā mea hiki i thiazolidinedione. ʻO ka lāʻau lapaʻau ka agonist koho o nā receptor gamma kikoʻī o nā mabenzymes pilikino.

Ma ka maʻi mellitus o ka ʻano lua, e hōʻemi ana ka lāʻau i ka pale ʻana i ka insulin i nā hāpona o nā ate.

Hiki ke loaʻa i ka puʻuwai, ka ʻili a me ka kiko adipose. Ma muli o ka hiki ʻana o nā mea i hōʻalo ʻia, ka loli ka huaʻilima o nā ʻano kahi i hoʻoholo ʻia ai ka naʻau o ka insulin. Hoʻopili lākou iā lākou i ka hoʻokaʻawale ʻana i nā kūlohelohe o ke koko.

ʻO ke kaʻina metabolic o ka metabolic metabolism e hoʻi hou ana i ka maʻamau.

Ke emi ka pae o ka pale ʻana o nā kikoila peripheral, kahi i hāʻawi ʻia i ka wikiwiki wikiwiki o ka glucose i hilinaʻi ʻia o ka insulin. I kēia hihia, maʻamau ka pae o ka hemoglobin i loko o ka serum koko.

Ma ka maʻi mellitus o ka lua, ua ʻemi nui ʻia ka pale ʻana o ka naʻau o nā pehu o nā ate. Ke alakaʻi kēia i ka emiʻana o ka hōʻiliʻili o ka glucose i ka koko, a emi pū ka pae o ka insulin i ka plasma.

Lapaʻau lāʻau

Ma hope o ka lawe ʻana i ka pāpale ma ka ʻōpū ʻole, ua nānā ʻia ka nui o ka pioglitazone i loko o ke koko koko ma hope o ka hapalua hola. Inā ʻoe e lawe i nā paila ma hope o ka ʻai ʻana, a laila e loaʻa ka hopena i kekahi mau hola. ʻO Bioavailability a me ke hoʻopiʻi i nā ʻōmehana koko ke kiʻekiʻe.

Hoʻonui ka Pioglitazone metabolism i loko o ka ate. ʻO ka hapalua hapalua he 7 hola. Hoʻopili ʻia nā mea kūlohelohe i ke ʻano o nā metabolites maʻamau me ka urine, bile a me nā feces.

Hoʻopiliʻia nā mea koʻikoʻi o Astrozone i ke ʻano o nā metabolite maʻamau me ka urine.

Nā Hoʻohui

ʻO nā contraindications kūpono loa i ka hoʻohana ʻana i ka lāʻau lapaʻau nā:

hypersensitivity i nā ʻāpana,
maʻi diabetes type 1
maʻi maʻamau ketoacidosis,
nā pilikia ma ke ake a me nā ʻōpū,
hapai a me lactation,
keiki malalo o 18 makahiki,

Me ka mālama pono

Pono ʻia ka mālama ʻana ke kuhikuhi ʻana i kahi lāʻau i ka poʻe i loaʻa ka mōʻaukala:

ka māla ʻana
anemia
hana a hoʻohālikelike i ka ʻōpū o ka naʻau.

Me ka maʻi diabetes

Inā ʻoe e hoʻohana pū i ka lāʻau lapaʻau me nā loiloi hypoglycemic a i ʻole ka metformin, pono e hoʻomaka ʻia ka lāʻau lapaʻau me ka liʻiliʻi liʻiliʻi, i.e. mai lawe ma kahi o 30 mg i ka lā.

Hoʻohui ka hana me ka insulin e pili ana i ka hoʻohana ʻana i hoʻokahi ʻona ma Astrozone ma 15-30 mg i hoʻokahi lā, a i ʻole ka like o ka nui o ka insulin e kū a i kahi emi iki paha, i loko o ka hihia o ka hypoglycemia.

Nā ʻāpana ʻaoʻao o Astrozone

Ke kumu nei i kahi ʻano ʻino, hiki ke hele mai me ka hoʻopiʻi ʻole a hōʻino hewa paha.

Hiki i ka Astrozone ke hoʻoikaika i ka hana o ka naʻau.

ʻO ka aneane maʻamau, ua ʻā nā poʻe maʻi i nā ʻōwili. Hiki paha ke hoʻopili ʻia ka ʻike maka ʻike i nā hoʻololi o ke kaʻe o ka glucose o ke koko, ʻoi loa ma ka hoʻomaka ʻana o ka ʻoihana. I nā hihia pinepine, hiki i ka ulu ʻana o ka puʻuwai puʻuwai.

Hoʻopilikia i ka hiki ke mālama i nā mīkini

No ka mea ma muli o ka hoʻohana o kēia lāʻau lapaʻau, hiki i ka hoʻomohala ʻana o ka hypoglycemia, i hele pū ʻia me ka ʻalo ʻana a me ka huhū huhū, pono ʻoe e hōʻole i ke kaʻa i kahi kaʻa a hoʻokipa i nā ʻano lāʻau paʻakikī. Hiki i kēia kūlana ke hoʻopilikia i ka hopena o ka hopena a me ka neʻe.

Pono ʻoe e hōʻole i ka kaʻa i ka wā o ka mālama ʻana me Astrozone.

Nā ʻōlelo kikoʻī

Me ka mālama aka, ua kau ʻia ka lāʻau lapaʻau i nā maʻi me ka nui o ka edema, a me ka ʻoi ma ka ʻoi (ma mua o ka hoʻokō ʻana e hiki mai ana). Hiki i ka anemia ke ulu ʻana (kahi emi lohi i ka hemoglobin e pili pinepine ana i ka piʻi nui o ka nui o ke koko e holo ana i loko o nā moku.

Pono ka nānā ʻana i ke kiʻekiʻe o ka hypoglycemia i ka wā e hoʻohana ai i ka mālama ʻana me ka ketoconazole.

Hoʻohana i ka wā hāpai a me ka lactation

ʻO ka lawe ʻana i nā papa e contraindicated i ka wā gestation a i ka wā o ka ʻōpū. ʻOiai ua hōʻike ʻia ua loaʻa i ka mea ola i nā hopena teratogenic o ka ulu ʻana, ʻoi aku ka maikaʻi.

ʻO ka lawe ʻana i nā papa Astrozone i contraindicated i ka wā o ka hoʻoulu ʻana.

ʻO overroose Astrozone

ʻAʻole i hōʻike mua ʻia nā hihia o ka overdose e Astrozone. Inā lawe ʻole ʻoe i ka lāʻau nui o ka lāʻau, hiki i ka hopena ʻino loa e hōʻike ʻia ana e ka maʻi dyspeptic a me ka hoʻomohala ʻana o ka hypoglycemia.

I ka hihia o nā hōʻailona hōʻailona o kahi overdose, pono ia e hoʻokō i ka hōʻailona hōʻailona a hiki i ke nānā ʻia ʻana o nā mea leʻaleʻa a pau loa.

Inā hoʻomaka ka hypoglycemia e ulu, ʻaʻa detoxification a me ka hemodialysis e pono ai.

Inā hoʻomaka ka hypoglycemia ma kahi o ka overdose o Astrozone, pono ʻia paha hemodialysis.

Hoʻopili pū me nā lāʻau ʻē aʻe

Ma ka hoʻohana ʻana i ka hui me nā mea hoʻohālikelike waha, ua ʻike nui ʻia ka hōʻemi nui o nā metabolite ikaika o ka mea ikaika. No laila, ua hoʻemi ʻia ka maikaʻi o ka hoʻohanaʻana i nā contraceptives.

ʻO ke kaʻina o ka metabolism pioglitazone i loko o ka pepeke i mea pale ʻole i ka wā e hoʻohana ʻia me ka ketoconazole.

Hoʻolaha ka waipuna

ʻAʻole hiki iā ʻoe ke hoʻokau i ka lāʻau lapaʻau me ka lāʻau lapaʻau a inu i ka waiʻona. Hiki i kēia ke alakaʻi i nā hopena hoʻonui i ka ʻōnaehana o ka huhū. Hoʻonui ka pilikia o ka hoʻomohala ʻana i nā hanana dyspeptic. Hoʻonui pinepine ke ʻano o nā ʻōmole.

Aia kekahi mau huahana o Astrozone e like me ia ma ka hopena o ka hana ikaika a me ka hopena therapeutic:

ʻĀina Diab Norm
Kauahi
Amalvia
ʻĀina Pioglar
Pioglite
Piouno.

ʻO ka lā kau

ʻAʻole iʻoi aku ma mua o 2 mau makahiki mai ka lā i hana ʻia ai i hōʻike ʻia ma ka hīnaʻi. Mai hoʻohana i ka lā hoʻopau.

ʻO ka analogue o Astrozone - hiki ke hoʻohana ʻia ʻo Piuno i ka hopena o ka lā pau.

1 ml mea kiko

Meloxicam - 6.00 mg

Nā mea hoʻihoʻi: meglumine - 3.75 mg, poloxamer 188 - 50.00 mg, tetrahydrofurfuril macrogol (glycofurol) - 100.00 mg, glycine - 5.00 mg, sodium klorida - 3.00 mg, 1 M sodium hydroxide solution - i ka pH o 8.2-8.9, wai no ka olomo - a hiki i ka 1 ml.

ʻO kekahi ampoule (2.5 ml) loaʻa 15 mg o meloxicam.

wai uani kaomi ʻōmaʻomaʻo.

Nā Hōʻike Manaʻo Astrozone

Oleg, 42 makahiki, Penza

Ua lōʻihi wau i ka maʻi ʻana i ka maʻi diabetes 2. Ua kuhikuhi ʻia nā ʻano he nui he nui nō naʻe, ʻaʻole ka lōʻihi o ka hopena o ia mau mea a mākou e makemake ai. ʻAʻole hoʻi i hiki iaʻu ke hana i nā injections i ka manawa āpau. A laila kuhikuhi ke kauka iaʻu e inu i nā lāʻau ʻo Astrozone. Uaʻike koke nei au i ka hopena o lākou. Ua loli koke ke ʻano maʻamau. Hoʻi hou ka nui o ke kō koko koko i loko o hoʻokahi mau pule. I kēia hihia, ua lawa ka papa ʻaina 1 no ka lā holoʻokoʻa. Ua hauʻoli wau i ka hopena o ka loaʻa ʻana.

Andrey, 50 makahiki, Saratov

Ua kuhikuhi ke kauka i nā papa ʻo Astrozone ma 15 mg i kēlā me kēia lā ma muli o ka hoʻomaka ʻana o ka hoʻomaʻamaʻa aia i nā hōʻike maʻi kino. Akā, ʻaʻole kōkua kēia ʻano hana i ka pau ʻana. Hoʻomaopopo ke kauka i ka hoʻonui ʻana i ka maʻi a hiki i ka 30 mg no kēlā me kēia lā, kahi mea i hāʻawi koke i kahi hopena maopopo. Wahi a ka loiloi, ua hōʻemi ka palena o ka glucose. Hoʻomaʻa mau ka hopena a hiki ke hoʻopau ʻia ka lāʻau lapaʻau. I ka hoʻomaka ʻana o nā hoʻokolohua i ka pōʻino, ʻōlelo ke kauka i ka mālama mālama ʻia o 15 mg i ka lā. Mālama ʻo Sugar i kahi pae like hoʻokahi no ka makahiki hoʻokahi, no laila ʻaʻole hiki iaʻu ke ʻōlelo iki i kekahi mea no ka lāʻau lapaʻau.

ʻO Peter, 47 makahiki, ʻo Rostov-on-Don

ʻAʻole kūpono i ka lāʻau lapaʻau. ʻAʻohe aʻu i manaʻo i kekahi hopena mai nā kumu mua mai o 15 mg. Wahi a nā hopena o nā loiloi, ʻaʻohe loli nui. I ka manawa e hoʻonui nui ʻia ai ka hopena i ka 30 mg, ua loli nui ke kūlana maʻamau. Hoʻokomo ka hypoglycemia koʻikoʻi, nā mau maʻi o nā mea i hōʻemi wale ʻia iaʻu. Pono wau e hoʻololi i ka lāʻau.

E hoʻokuʻu i ke ʻano, ka hoʻonohonoho ʻana

Loaʻa ka lāʻau lapaʻau i ke ʻano o ka hopena no ka hoʻokele intramuscular. ʻO ka mea waiwai he meloxicam ma kahi ʻano ikaika. ʻO 1 ml o ka hoʻonā i nā 6 mg o ka meloxicam.

E like me nā mea kōkua o ka glycine, sodium hydroxide, glycofurol, sodium chloride, wai no ka hōʻemi ʻana.

Ma muli o kona hopena koho, ka mea ikaika o ka lāʻau lapaʻau liʻiliʻi e hāʻawi i ka hoʻoulu ʻana i ka pilikia o erosive o ka ʻōpū a me ka duodenum.

Pae kumu noi, dosage

Hoʻololi ʻia ka hoʻokele Intramuscular o ka lāʻau i nā lā mua o ka mālama ʻana. I ka wā e hiki mai ana, ua ʻōlelo ʻia ka hoʻololi ʻana i ka hoʻokele waha o ka lāʻau (nā papa).

ʻO ka dosage i kēlā me kēia lā i ʻōlelo ʻia mai 7.5 a 15 mg. Hoʻoholo ʻia ka lāʻau kauka a me ka lōʻihi o ka lāʻau lapaʻau, e noʻonoʻo ana i nā hōʻike o ka maʻi a me nā ʻano pilikino o ke kino o ka mea maʻi.

ʻO nā mea maʻi e pili ana i ka hemodialysis a loaʻa iā lākou ka mōʻaukala o ka hana koʻikoʻi koʻikoʻi ʻoi aku ka nui o ke koʻikoʻi o kēlā me kēia lā o 7.5 mg.

ʻAʻole kōkua ʻia ʻo Arthrosan e hui pū ʻia i ka syringe like ʻole me nā lāʻau lapaʻau ʻē aʻe. ʻAʻole hiki ke ʻae ʻia ka intravenous hoʻokele o ka lāʻau.

Hoʻopili me nā hui ʻē aʻe o nā lāʻau lapaʻau

Pono kēia lāʻau lapaʻau me ka mālama nui loa i ka wā like i ka wā like me nā lāʻau mai nā pūʻulu anticoagulants (Warfarin), nā mea hana antiplatelet (Plavix, Clopidogrel), inu wai, papa corticosteroids (Prednisolone), Fluoxetine, Paroxetine.

ʻAʻole pono e hoʻohana ʻia ʻo Arthrosan e hui pū me nā lāʻau ʻē aʻe mai ka pūʻulu o nā lāʻau anti-inflammatory non-steroidal.

Me ka hoʻohana pū ʻana me ka diuretics, piʻi nui ka ulu ʻana o ka hoʻoulu ʻana i nā renal.

Me ka hoʻohana pū ʻana me nā lāʻau lapaʻau mai ke koko kiʻekiʻe, e emi paha ko lākou hypotensive.

Ke hui pū me ka vitamin K, heparin, serotonin reuptake inhibitors, a me nā fibrinolytics, piʻi ka nui o ke koko.

Pākuʻi hou

Me ka hoʻomohala ʻana o ke ʻano kino e hōʻike ai i ka hōʻino ʻole o ka hana maʻamau o nā pūpū (ka ʻeha a me ka ʻonaninike o ka ʻili, ka luaʻi ʻana, ka urineʻeleʻele, ke ʻeha i loko o ka ʻōpū), ʻo ka hoʻohana ʻana i ka lāʻau e pono e hoʻokuʻu koke a nīnau ʻia me ke kauka.

Hiki paha iā Arthrosan ke hōʻike ʻana i nā maʻi maʻi maʻi.

ʻAʻole hiki ke hoʻohana ʻia kēia lāʻau lapaʻau ma ka prophylaxis o ka thrombosis, ʻoiai e hiki ke hoʻēmi i ka platelet aggregation.

Nā kumumanaʻo o nā ʻōlelo ʻo Arthrosan

ʻO nā lāʻau lapaʻau e hōʻike nei i nā mea hoʻohālike o ka hoʻomākaukau ʻana o Arthrosan: Melox, Amelotex, Mirlox, Mesipol, Movasin, Movalis. Inā pono e hoʻololi i ka lāʻau lapaʻau, pono ʻoe e kamaʻilio mua me kāu kauka.

ʻO ka mālama ʻana i nā kaha ʻōlelo e pono ai ʻo Arthrosan e mālama ʻia i kahi wahi pouli, pale ʻia mai ka lā ʻoluʻolu, i ka poʻe keiki. He kikowaena mālama - ʻaʻole iʻoi aku ma mua o 25 degere.

Pharmacodynamics a me ka pharmacokinetics

ʻO ke ʻano waiwai meloxicam- ʻehu oksikama. ^ E Ha yM. Loaʻa ia kahi hopena anti-inflammatory, poloka i nā synthesisa laila a me ka ʻaʻioe chicooxygenase-2ka mea komo i ka pōkole hoʻohuʻihuʻi arachidonic.

Ma lalo o ka hopena o ka meloxicam, hana nā mea hoʻonāukiuki a panipuna paia pāhoʻemi nui, hōʻemi ʻia ka hopena nā hopena me nā mea hoʻopuka manuahi. ^ E Ha yM. Hoʻopilikia ʻia Anesthesia ma muli o ka emi ʻana o ka hana o ka pilina o ka prostaglantins a neʻe palena.

Loaʻa ka paʻa ʻana i nā koina nui ma loko o ʻekolu a i ʻelima lā. Hoʻopili maikaʻi ia i nā protein plasma (99% a i luna). ʻAbollelo ʻiai ka puʻuwai, ka hana i ka 4 metabolites. ʻAʻole lākou i ka hana i nā kaʻina pharmacodynamic. Hoʻopau nā Metabolites i nā feces a me ka urine ma kahi o 15 a 20 mau hola.

Nā hōʻailona no ka hoʻohana ʻana

ma ka halekino i nā mea maʻi (ʻoi aku ka nui o ka poʻe kaumaha) ʻaʻole i hoʻokō i ka mana glycemic e ka hahai ʻana i kahi meaʻai a me ka hoʻokō ʻana i nā ʻano kino a no ka mea o ka hoʻokuʻi ʻana o ka metformin,

i ka hui pū me nā metformin i nā mea maʻi (ʻoi aku ka momona nui) ʻaʻole i hoʻokō i ka mana glycemic kūʻē i ke kumu o ka nui o ka nui o ka metformin,

i ka hui pū ʻana me nā derivatives sulfonylurea i nā maʻi e loaʻa ʻole i ka mana glycemic e kū'ē ana i ke kumu o ka nui o nā dosis i hoʻomākaʻi ʻia o nā derivatives sulfonylurea a no laila ke kue ʻana o ka metformin.

i hui pū me nā derivatives metformin a me sulfonylurea i nā maʻi (ʻoi aku ka poʻe i kaumaha nui) ʻaʻole i hoʻokō i ka mana glycemic i ka wā hui pū me nā metformin a me nā derivatives sulfonylurea,

i ka hui ʻana me ka insulin i nā poʻe maʻi e loaʻa ʻole i ka mana glycemic i ka wā e hoʻohana ai i ka insulin a no ka mea o ka hoʻokuʻi ʻana o ka metformin.

Nā ʻōkuhi no ka hoʻohana ʻana iā Arthrosan (Ke ʻano a me ka helu ʻana)

Lawe ʻia nā papa ʻāpana i ka lā i ka lā, me ka meaʻai, holoi ʻia me ka wai. ʻO ka ʻōmapa i ʻōlelo ʻia i kēlā lā i kēia lā mai 7.5 mg a 15 mg, e hilinaʻi ana i ka nui o ka maʻi ʻeha a me ke ʻano o ka maʻi.

Inā ʻaʻole hiki ke lawe ʻia ka lāʻau ʻiʻohiki ke koho kaina intramuscular.

Nā kaha ʻōlelo o Arthrosan, nā ʻōlelo e hoʻohana ai

Kuhi ʻia nā ʻōkuhi Arthrosan no ka ʻehaʻeha ma mua o nā lā maʻi mua. Hōʻailona ka hua lāʻau injections intramuscularlyhohonu i ka lole. ʻO ka lā helu i kēlā me kēia lā mai 7.5 a 15 mg, a hoʻomaka ʻia ke lapa me nā liʻiliʻi liʻiliʻi a hoʻonui a hiki i ka hopena i makemake ʻia.

ʻAʻole iʻoi aku i kahi mea i hōʻike ʻia noʻeau, hiki ke hoʻonui aʻe i ka hopena o nā hopena ʻaoʻao.

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau

ʻO Meloxicam kahi lāʻau anti-inflammatory non-steroidal (NSAID), e pili ana i nā derivatives o ka enolic acid a loaʻa kahi hopena anti-inflammatory, analgesic a me antipyretic. Hoʻokumu ʻia ka hopena anti-inflammatory o ka meloxicam ma nā hiʻohiʻona maʻamau o ka mumū. ʻO ke kaana o ka hana o ka meloxicam ʻo kona hiki ke pale i ka synthesis o prostaglandins, ʻike ʻia i nā mea hoʻoponopono kumu. In vivo meloxicam pale i ka syntaglandin synthes ma ke kahua o ka mumū i ka ʻoi aku i kahi kiʻekiʻe ma mua o ka gastosa mucosa a i ʻole nā ʻiliʻili.

Hoʻopili ʻia kēia mau ʻokoʻa a kahi pale i koho ʻia no ka cyclooxygenase-2 (COX-2) i hoʻohālikelike ʻia me cyclooxygenase-1 (COX-1). Ke manaʻoʻiʻo ia ka paleʻana o ka COX-2 e hāʻawi i ka hopena therapeutic o NSAIDs, ʻoiai ke keʻa nei i ka hananaenX COX-1 ka kuleana no ka hopena o ka hopena mai ka ʻōpū a me nā ʻōpū. ʻO ka koho ʻana o ka meloxicam e pili ana i ka COX-2 i hoʻopaʻa ʻia i nā ʻōnaehana hōʻike like ʻole, ma ka vitro a me nā vivo. Hōʻike ʻia ka mana koho o meloxicam e kālai i ka COX-2 i ka wā e hoʻohana ai i ka koko vitro a pau o ke kanaka ma ke ʻano he ʻano hoʻāʻo.

Ua hoʻokumu ʻia e meloxicam (ma nā wai o 7.5 a me 15 mg) i hana ikaika i ka COX-2, e hana nui ana i ka hopena o ka pale ʻana i ka hoʻoulu ʻia ʻana o ka prostaglandin E2 e hoʻoulu ʻia ana e ka lipopolysaccharide (kahi hopena i hoʻomalu ʻia e COX-2) ma mua o ka hana o ka thromboxane, ka mea e pili ana i ka hui koko. (kūpaʻa ʻia e COX-1).Ua hilinaʻi ʻia kēia mau hopena. Ua hōʻike nā haʻawina ma v v i ka meloxicam (ma nā kiko o 7.5 mg a me 15 mg) ʻaʻohe hopena i ka platelet aggregation a me ka manawa hoʻokahe.

Ma nā haʻawina haukapila, nā hopena hopena mai ka gastrointestinal tract (GIT) ma kahi holoʻokoʻa e kū pinepine pinepine i ka wā e lawe ana i ka meloxicam 7.5 a me 15 mg ma mua i ka lawe ʻana i nā NSAID e like me ka hoʻohālikelike ʻana. ʻO kēia ʻokoʻa i ka pinepine o nā hopena o ka hopena mai ka gastrointestinal tract ka mea nui ma ka mea i ka wā e lawe ai i ka meloxicam, ʻike pinepine ʻia i nā hanana like ʻole o ka dyspepsia, ka luaʻi, ka ʻōpū, ka ʻeha o ka ʻōpū. ʻO ke pinepine o nā perforations ma ke kaʻi gastrointestinal kiʻekiʻe, nā ʻōpio a me ke koko, i pili pū me ka hoʻohana ʻana o meloxicam, he haʻahaʻa loa ia a hilinaʻi i ka hopena o ka lāʻau lapaʻau.

Lapaʻau lāʻau

Hoʻopau piha ka Meloxicam ma hope o ka hoʻokele intramuscular. Palapala kūlohelohe pili e pili ana me ka bioavailability o ka waha he aneane 100%. No laila, ke koi aku i ka injectable i ke ʻano wahaheʻe o ke koho i ka pau ʻole e pono. Ma hope o ka hoʻomoe ʻana o 15 mg o ka lāʻau intramuscularly, ua hōʻea ke kuhi plasma pae kiʻekiʻe (ma kahi o 1,6 - 1,8 μg / ml) ma loko o kahi o 60 - 96 mau minuke.

Hoʻopili maikaʻiʻo Meloxicam i nā protein plasma, ʻo ka mea nui me ka albumin (99%). Penetrates i loko o ka wai synovial, ʻo ka neʻe ʻana i ka wai synovial ma kahi o 50% o ka nānā ʻana o ka plasma. ʻO ka nui o ka hoʻoili ʻana, ma kahi o 11 lita. ʻO nā kūʻokoʻa o ka pilikino he 7-20%.

ʻO Meloxicam ua aneane piha i ka pili o ke ake me ka hoʻokumu ʻia o 4 deracatives i ʻole ka hana. ʻO ka metabolite koʻikoʻi, 5-carboxy-meloxicam (60% o ka momona), i hoʻokumu ʻia e ka hopena o ka oxidation o ke metabolite waena, 5-hydroxymethylmeloxicam, kahi hoʻi i hala, akā i ka liʻiliʻi (9% o ka laʻana). Ua hōʻike i nā haʻawina vitro ua hiki ke nui i ka nui o ka CYP2C9 isoenzyme i kēia hoʻololi o ka metabolic, a me ka CYP3A4 isoenzyme ka hana hou. I ka hana ʻana o ʻelua mau metabolites (ʻo ia pū, kahi, 16% a me 4% o ka lāʻau o ka lāʻau), akā pili ka peroxidase, ka hana a kēlā me kēia kanaka ʻē aʻe. Leʻaleʻa

Hoʻokuʻu ʻia ʻo ia ma o nā ʻōpū a me nā ʻili, ʻoi loa ka ʻano o nā metabolites. Ma kahi ʻano i hoʻololi ʻole ʻia, ʻoi aku ka emi o 5% o nā lā i kēlā me kēia lā i hoʻopā ʻia me nā feces, i loko o ka urine i loko o kahi ʻano loli ʻole, ʻike ʻia ka lāʻau lapaʻau ma loko o nā huina noa. ʻO ka maʻamau hapa hapalua-ola o meloxicam ʻokoʻa mai 13 a 25 mau hola. Hoʻolaha nā Plasma ma nā aihue 7-12 ml / min ma hope o ka hoʻohana hoʻokahi. Hōʻike ʻo Meloxicam i ka lineac pharmacokinetics i nā koina o 7.5-15 mg me ka hoʻomehana intramuscular.

ʻO ka hemahema o ka ate a me / a hana ʻana i kaʻeha

ʻO ka nele o ka hana ate, a me ka hoʻomaʻemaʻe kino ʻole o ka hopena, ʻaʻole ia e pili i ka pharmacokinetics o meloxicam. ʻOi aku ka kiʻekiʻe o ka haʻalele ʻana o ka meloxicam mai ke kino i mea kiʻekiʻe i nā mea maʻi me nā maʻi renal maʻalahi. ʻOi aku ka liʻiliʻi ʻo Meloxicam e hoʻopili i nā protein plasma i nā mea maʻi me ka maikaʻi ʻole o ka hope. I ka hiki ʻole o ka renal failed, kahi piʻi i ka nui o ka hoʻoili e hiki ke alakaʻi i nā kikowaena kiʻekiʻe o ka meloxicam manuahi, no laila, i loko o kēia mau mea maʻi ka maʻi nui o kēlā me kēia lā ʻaʻole pono e hoʻonui i ka 7.5 mg.

ʻO nā maʻi maʻi kuikahi i hoʻohālikelike ʻia me nā mea maʻi ʻōpio he mau ʻāpana like me nā lāʻau lapaʻau like. I nā poʻe maʻi ʻelemakule, ʻoi aku ka nui o ka hoʻokaʻawale plasma i ka wā o ka tulaga kūlike o ka pharmacokinetics he haʻahaʻa loa ma mua o nā mea maʻi ʻōpio. Loaʻa i nā wahine ʻoi aku ka nui o nā AUC mau kiʻekiʻe (ʻo ka wahi ma lalo o ka pihi-ʻoihana paʻa) a me ka hapalua o ka hapalua-ola, hoʻohālikelike ʻia me nā mea maʻi ʻōpio o nā kāne like ʻole.

ʻLoe a me ke kākele

ʻOsteoarthritis me ka ʻeha: 7.5 mg i kēlā me kēia lā. Inā kūpono, hiki ke hoʻonui ʻia kēia dosis i 15 mg i ka lā.

ʻO ka lāʻau māmā o Rheumatoid: 15 mg i kēlā me kēia lā. Aia i ka hopena therapeutic, hiki ke hoʻemi ʻia kēia hōʻemi i 7.5 mg i kēlā me kēia lā.

Ankylosing spondylitis: 15 mg i ka lā. Aia i ka hopena therapeutic, hiki ke hoʻemi ʻia kēia hōʻemi i 7.5 mg i kēlā me kēia lā.

I ka poʻe maʻi me ka piʻi nui o nā hopena ʻino (kahi mōʻaukala o nā maʻi ʻeha gastrointestinal, ka loaʻa ʻana o nā mea i hoʻopilikia ʻia no ka maʻi cardiovascular), ua ʻōlelo ʻia e hoʻomaka i ka mālama ʻana me kahi maʻi o 7.5 mg i kēlā me kēia lā (e ʻike i ka ʻāpana "Kūlana Kūlana"). I ka poʻe maʻi me ka pilikia ʻole o ka hana ʻana i ka hemodialysis, ʻaʻole pono ka nui o ka lāʻau lapaʻau ma loko o 7.5 mg i ka lā.

Nā ʻōlelo ʻōlelo ʻao

ʻOiai ka mea kūpono i ka hopena ʻino e pili ana i ka maʻi a me ka lōʻihi o ka mālama ʻana, pono e hoʻohana ʻia ka nui o ka hopena a me ka lōʻihi o ka hoʻohana ʻana. ʻO ka paona ʻana i hōʻike ʻia no kēlā me kēia lā he 15 mg.

ʻO ka hoʻohana hui

ʻAʻole ʻoe e hoʻohana i ka lāʻau lapaʻau i ka manawa like me nā NSAID. ʻO ka huina o kēlā me kēia lā o ka lāʻau ʻo Arthrosan® i hoʻohana ʻia i nā ʻano like me ʻokoʻa ʻaʻole pono e oi aku i ka 15 mg.

Hoʻomaopopo wale ka hoʻomehana Intramuscular i ka lāʻau i nā lā mua o ke kau ʻana i ka maʻi. Hoʻomau ka hoʻomaʻamaʻa hou ʻana me ka hoʻohana ʻana i nā palapala hoʻohālikelike waha. ʻO ka dosis i ʻōlelo ʻia he 7.5 mg a i ʻole 15 mg 1 mau manawa i kēlā me kēia lā, e pili ana i ka nui o ke hōʻeha a me ka paʻakikī o ke kaʻina hana.

Hoʻohana ʻia ka lāʻau lāʻau e ka ʻōlelo hohonu intramuscular.

ʻAʻole hiki ke hoʻokele ʻia ka lāʻau lapaʻau.

Kuhi i ka hiki ʻole o ka Arthrosan hiki ke hoʻopili ʻia, ʻo ka hopena o ka hoʻokele intramuscular e hui pū ʻia i loko o ka syringe like me nā lāʻau ʻē aʻe.

Loaʻa ka hopena

Ua wehewehe ʻia nā hopena ʻokoʻa ma lalo, ʻo ka pilina o ka hoʻohana me ka meloxicam i manaʻo ʻia e hiki.

ʻO ka hopena o ka ʻaoʻao i hoʻopaʻa ʻia i ka wā o ka hoʻohana ʻana i ka kūʻai ʻana ma hope, kūʻai ʻia ka pilina me ka hoʻohana ʻana o ka meloxicam i manaʻo ʻia he mea hiki ke mālama ʻia me kahi.

Hoʻohana ʻia kēia mau ʻāpana i loko o nā papa ʻōnaehana ʻōnaehana e like me ka leʻa o ka hopena o nā ʻaoʻao:

pinepine pinepine (> 1/10),
pinepine (> 1/100. 1 / 1,000. 1 / 10,000. ʻO nā wehe mai ke koko a me ka ʻōnaehana lymphatic:

A jarang - leukopenia, thrombocytopenia, hoʻololi i ka nui o nā pili koko, me nā hoʻololi i ke ʻano leukocyte.

ʻO ka hanana ʻōnaehana maʻi:

ʻO ka maʻamau, nā kumuhana hypersensitivity e like me nā manawa koke loa, ʻaʻole i loaʻa - pīhoihoi anaphylactic *, ʻano hopena anaphylactoid. ʻO nā maʻi noʻonoʻo: hiki ke hoʻololi ʻia -

ʻAʻole paʻa ʻia - hūnā *, hilahila *. Nā maʻi mai nā papa o ka nupepa: ʻO ka manawa - ke poʻo, ke kaumaha - mau ʻaluhi, ka hiamoe.

Nā hana kolohe o nā kino o ka ʻike, hoʻolohe a me ke kīpē labyrinth: Ka pinepine - vertigo,

Aele - conjunctivitis *, ʻike maka ʻole, me ke aniani blurr *, tinnitus. Nā kipi o ka naʻau a me ke koko:

ʻO ka pinepine - ʻoi ka hoʻonui o ke koko, ke ʻano o ka "wikiwiki" o ke koko i ka maka, ke ʻolua - ka puʻuwai ʻōpū.

Nā kuhihewa o ka ʻōnaehana hanu:

A jarang - bronchial asthma i loko o nā maʻi e maʻi kūlohelohe i ka acetylsalicylic acid a me nā NSAIDs.

Nā hewaʻole o ka e / gastrointestinal tract: pinepine - ʻeha o ka ʻōpū, ka ʻōpū, ka maʻi ʻōpū, ka lua, ka luaʻi,

ʻO ka pinepine - ākea a ʻike maoli paha iā gastrointestinal, gastritis *, stomatitis, constipation, bloating, belching, Rarely - gastroduodenal ulia, colitis, esophagitis, aneane loa - hoʻoweliweli o ka ʻeha gastrointestinal. Nā kuhi hewa o ka pūpū a me ka pāpili:

He pinepine - nā loli hoʻololi i ka hana o ka hana maʻi (no ka laʻana, ka hoʻonui ʻana o ka transaminases a i ʻole bilirubin), aneʻi loa - hepatitis *.

Hōʻalo i nā ʻili a me nā ʻāpana ʻili.: ʻO ka pinepine - angiotek *, ka ʻeha, ka ʻāʻī o ka ʻili.

Kekahi i nā mea hoʻonā manuahi epidermal *, ʻ syndromelelo Stevens-Johnson *, urticaria,

Kuhi loa-bullous dermatitis *, erythema multiforme *, ʻaʻole i loaʻa - photosensitivity.

Nā kuhihewa o nā pūpū a me nā hana urinary:

ʻO ka pinepine - nā hoʻololi i loko o nā hōʻailona o ka hana o ka keiki (hoʻonui i ka hana a me / a ma urea paha i ka serum koko), nā maʻi urination, e komo pū ka mālama ʻana i ka urinary *.

Kuhi loa - hoʻonāukiuki nā māla renal *.

Nā hana kolohe o nā genitals a me nā momona mommary:

- Lā o ka lohi -

ʻAʻole paʻa - kauhi i ka wahine.

ʻO nā maʻi maʻamau a me nā pilikia i ka pūnaewele hōʻola:

ʻO ka pinepine - ʻeha a me ka ʻāʻī ʻana ma ka wahi o ka inikini.

Hoʻohana ʻia me nā lāʻau lapaʻau e pale i ka ʻōpū o ka iwi (e.g. methotrexate) hiki ke hoʻowalewale i ka cytopenia.

ʻO ka puhipuhi Gastrointestinal, ulia, a me ka perforation hiki ke hōʻeha.

ʻO kekahi o nā NSAID, ʻaʻole lākou e hoʻokaʻawale i ka hiki o ke ʻano o ke ʻano o ka nephritis interstitial, glomerulonephritis, necrosis medullary necrosis, nephrotic syndrome.

Hoʻopili pū me nā lāʻau ʻē aʻe

Hoʻopili kekahi mau mea hanu o ka syntaglandin synthes, e pili ana i ka glucocorticoids a me ka salicylates, ka hoʻopili ʻana me ka meloxicam e hoʻonui i ka pilikia o ka ulceration i ka gastrointestinal tract a me ke kaila gastrointestinal (ma muli o synergism o ka hana). ʻAʻole hoʻohana ʻia ka hoʻohana pono ʻana me nā NSAID ʻē aʻe. ʻO nā anticoagulants no ka hoʻokō waha, heparin no ka hoʻohana ʻana i nā ʻōnaehana, nā mālima thrombolytic - ka hoʻokūkū pū me ka meloxicam e hoʻonui i ka hopena o ke kahe. I ka hihia o ka hoʻohana like ʻana, pono e mālama pono ai i ka ʻōnaehana coagulation koko.

ʻO nā lāʻau Antiplatelet, serotonin reuptake inhibitors, hoʻopili paʻa me ka meloxicam e hoʻonui i ka hopena o ke kahe koko ma muli o ke kaohi ʻana o ka hana platelet. I ka hihia o ka hoʻohana like ʻana, pono e mālama pono ai i ka ʻōnaehana coagulation koko.

Hoʻomoe ka Lithium - Hoʻonui ka NSAID i ka pae o ka lithium i ka plasma ma ka hoʻohaʻahaʻa ʻana i kāna excretion e nā keiki. ʻAʻole hoʻolako ʻia ka hoʻohana pinepine ʻana o ka meloxicam me nā hoʻomākaukau lithium. Inā pono, e hoʻohana i ka manawa like me ka mālama ʻana i ka ʻike kūpono i ka paʻa ʻana o ka lithium ma ka papa holoʻokoʻa i loko o ke ʻano o ka hoʻomākaukau ʻana o ka lithium.

Methotrexate - NSAIDs hōʻemi i ka mea huna o methotrexate e nā keiki, a laila e hoʻonui i kona kaila ʻana i ka plasma. ʻO ka hoʻohana pinepine ʻana o ka meloxicam a me methotrexate (ma kahi momona ma mua o 15 mg no ka pule) ʻaʻole i kuhikuhi ʻia. I ka hihia o ka hoʻohana pinepine ʻana, pono e nānā pono ai i ka hana māla a me ka helu koko. Hiki i ka Meloxicam ke hoʻonui i ka hoʻonaninani hematologic o ka methotrexate, keu i nā mea maʻi me nā maʻi renal impaired.

ʻĀpanaʻi - ua hōʻike ʻia nā mea e hōʻemi paha nā NSAID i ka loaʻa o nā mea intrauterine, akā ʻaʻole i ʻike ʻia kēia.

Diuretics - ke hoʻohana ʻana o nā NSAID i ka hihia o ka hoʻomehana i ka maʻi o nā mea maʻi e hele pū ʻia me ka hopena o ka hana ʻoi ʻole ka hopena.

Nā mea antihypertensive (beta-blockers, angiotensin-hoʻohuli i ka hoʻohui o nā enzyme, vasodilators, diuretics). Hōʻemi nā NSAID i ka hopena o nā lāʻau antihypertensive, ma muli o ka kaohiʻana o nā prostaglandins me nā waiwai vasodilating.

ʻO Angagonensin II antagonist reseptor, me ka manomano e hoʻoneʻe nei i ka hoʻonaninani aʻoneʻelima, i ka wā e hoʻohana pū ai me nā NSAID, hoʻonui i ka hoʻohaʻahaʻa o ka kānana glomerular, kahi e hiki ai i ka hoʻomohala ʻana o ka maikaʻi ʻole o ka hana renal, no ka mea i nā mea maʻi me ka hana pūpū maʻi.

ʻO Colestyramine, e hoʻopaʻa ai i ka meloxicam ma ka ʻeha gastrointestinal, alakaʻi i kona wikiwiki wikiwiki.

Pemetrexed - me ka hoʻohana like ʻana o ka meloxicam a me ka pemetrexed i nā mea maʻi me ka hoʻomaʻemaʻe ʻana mai 45 a 79 ml / min, pono ke hoʻopau ʻia nā meloxicam i nā lā ʻelima ma mua o ka hoʻomaka ʻana o ka memetrexed a hiki i kēia mau lā 2 mau lā ma hope o ka pauʻana. Inā ka mea pono no ka hoʻohana like ʻana o ka meloxicam a me ka pemetrexed, a laila pono e nānā pono nā mea maʻi like, e pili ana i ka myelosuppression a me ka hopena o nā hopena o ka hopena mai ka gastrointestinal tract. I nā mea maʻi me ka cleince clearance haʻahaʻa ma mua o 45 ml / min, e lawe pū ana i ka meloxicam me ka pemetrexed ʻaʻole ʻia.

Nā NSAID, e hana ana i nā prostaglandins renal, i hiki i ka mea e hoʻonui ai i ka cyclosporin nephrotoxicity.

I ka wā e hoʻohana pū ai me nā lāʻau meloxicam kahi i ʻike maopopo i ka pale ʻana i ka CYP 2C9 a me / a i ʻole CYP ZA4 (a i ʻike ʻia e kēia mau enzymes), e like me ka sulfonylureas a i ka probenecid, pono e noʻonoʻo pono ka pilina o ka pharmacokinetic. Ke hui pū ʻia me nā ʻaina antidiabetic no ka hoʻokō waha (no ka laʻana, derivatives sulfonylurea, nateglinide), hiki i nā mea i hoʻolako ʻia e CYP 2C9, hiki ke alakaʻi i ka piʻi ʻana o kēia mau lāʻau a me meloxicam i ke koko. ʻO nā mea maʻi e lawe ana i ka meloxicam me ka sulfonylurea a i ʻole ka hoʻomākaukau ʻana nateglinide e kiaʻi pono i kā lākou koko koko ma muli o ka hiki o ka hypoglycemia.

Me ka hana like o nā antacids, cimetidine, digoxin a me furosemide, ʻaʻohe mea i ʻike nui ʻia nā pili lapaʻau.

ʻLoe a me ke kākele

Hoʻohana ʻia nā hoʻohālikelike me Arthrosan i nā lā mua o ka mālama ʻana i hoʻokahi lā i ka lā, ma 7.5 a 15 ml paha, ma hope o ka hoʻomau ʻia ke mālama me nā papa. Ma muli o ka hopena o ka hopena o ka hopena, ua manaʻo ʻia e hoʻohana i ka lāʻau lapaʻau ma nā palena liʻiliʻi e pono ai. Pono e hoʻopili ʻia nā ʻikepili me Arthrosan i ka intramuscularly wale ʻole a ke ʻole ʻia e kāwili ʻia ka lāʻau i hoʻokahi syringe me nā lāʻau ʻē aʻe.

Lawe ʻia nā papa Arthrosan i hoʻokahi manawa i ka lā, ʻoi aku ka maikaʻi. ʻO ka palena kiʻekiʻe loa o kēlā me kēia lā he 15 mg. Pākuʻi ʻia ka dosage i ka maʻi.

Me ka osteoarthrosis, e lawe i hoʻokahi papa o Artrozan 7.5 mg, i ka haʻalele ʻana o ka hopena, hiki i ka pāpālua ke hoʻopaʻa ʻia.
ʻO ka ʻōmato i ʻōlelo ʻia i kēlā me kēia lā no ka rheumatoid arthritis he 15 mg, ma hope o ka hoʻomaikaʻi ʻana, hiki ke hōʻemi ʻia ka nui o ka make ma 7.5 mg i kēlā me kēia lā,
Me ka ankylosing spondylitis, e lawe i hoʻokahi papa o Arthrosan 15 mg i kēlā me kēia lā.

E like me nā kauoha a Arthrosan, inā he hanana overdose, ʻeha ʻo ka eha epigastric, ʻike ʻole, nausea, hopu ʻana, hele aihue, a me ke kuʻuna o ka hepatic, e hele mai paha ka asystole.

Pono e mālama ʻia me ka hoʻohana ʻana i ka Arthrosan me nā lāʻau antihypertensive, methotrexate, diuretics, cyclosporine, hoʻomākaukau lithium a me kekahi mau lāʻau lapaʻau. Hōʻalo ka hōʻeha o ke kahe mai ke kiko o ka gastrointestinal me ka hoʻohana pinepine ʻana o Arthrosan me nā lāʻau hou anti-inflammatory non-steroidal, e like me ka acetylsalicylic acid.

Hoʻohana ʻia ʻo Arthrosan me ka akahele ʻole i ka hihia erosive a me ka ulcerative lesi o ka gastrointestinal tract i loko o ka anamnesis a i ka makahiki ʻelemakule.

Hoike e pili ana ia Arthrosan

He maikaʻi nā ʻike e pili ana i nā injections o Arthrosan. He haʻahaʻa a maikaʻi loa ka lāʻau lapaʻau. Nui nā mea i kōkua i ka pale ʻana i ka ʻeha me nā maʻi like ʻole. ʻO ka lawe ʻana i nā pale he like ka like me ka injections. ʻO nā mea minamina, nā hopena ʻokoʻa i ʻike ʻia i loko o ke ʻano o ka ʻeha, ka ʻōpū o ka ʻōpū a me ka maʻi o ka ʻōpū, akā e ulu pinepine nei kēia.