Telsartan (40 mg) Telmisartan > He hoʻomaʻemaʻe a me ke pale aku

Nā Papa 40 mg, 80 mg

Aia ma ka papa papa

mea waiwai - telmisartan 40 a 80 mg, kēlā

nā mea hoʻowalewale: meglumine, sodium hydroxide, povidone (PVP K 30), mannitol, magnesium stearate, wai

40 mg papa - nā papa mai ke keʻokeʻo a hiki i ke hina hina, nā kāpili i ʻano ʻia me ke kālai ʻia ʻo "T" a me "L" a he kakali ma kekahi ʻaoʻao a "40" ma kēlā ʻaoʻao.

80 papa papa - nā papa mai ke keʻokeʻo a hiki i ke hina hina, ke kālai ʻia me ke kālai ʻia ʻo "T" a me "L" a me ke kiʻī ma kekahi ʻaoʻao a ʻo "80" ma kēlā ʻaoʻao.

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau

Hoʻopili koke ʻia ʻo Telmisartan, ʻokoʻa ka nui o ka mea i hoʻopili ʻia. ʻO ka bioavailability o ka telmisartan ma kahi o 50%.

Ke lawe nei i ka telmisartan me ka meaʻai, ka nui o ka kaila o AUC (ma lalo o ka pihi ʻana i ka manawa o ka paʻa) ma waena o 6% (ma kahi iki o 40 mg) ka 19% (ma kahi kikoʻī o 160 mg). 3 mau hola ma hope o ke kauā ʻana, ka ʻike ʻana i ke kahe o ka plasma koko i waho, ma kahi o ka pāʻina. ʻO kahi emi iki ma AUC, ʻaʻole ia eʻae i kahi hōʻemi i kahi hopena therapeutic.

Aia kekahi ʻokoʻa ma ka nānā ʻana o ka plasma i loko o nā kāne a me nā wahine. ʻO Cmax (ʻoi loa ka ʻike) a me AUC paha ma kahi o 3 a 2 mau manawa ke kiʻekiʻe o nā wahine i hoʻohālikelike ʻia me nā kāne me ka loaʻa ʻole o kahi hopena koʻikoʻi.

ʻO ke kamaʻilio me nā protein plasma iʻoi aku ma mua o 99.5%, ʻo ka mea nui me ka albumin a me alpha-1 glycoprotein. ʻO ka nui o ka hoʻolaha e like me 500 lita.

Hoʻopili ʻia ka Telmisartan e ka hoʻopili ʻana i ka mea hoʻomaka me ka glucuronide. ʻAʻole i loaʻa kahi hana lapaʻau me kahi o ka conjugate.

He ʻano biexponential ʻo Telmisartan o ka pharmacokinetics me kahi hoʻopau hoʻopau hapa hapa-ola> 20 mau hola. Cmax a - i kahi kikoʻī liʻiliʻi - hoʻonui ʻia ʻo AUC disproportionately me ka ʻōpū. ʻAʻole i ʻike ʻia kekahi kumulāʻau koʻikoʻi o ke telmisartan.

Ma hope o ka lawelawe waha, ua pau nā telmisartan ma loko o ka ʻōpū o ka ʻōpū. Ka huina o ka urinary excretion ma mua o 2% o ka nui o ka huapalapala. Kūpono ka huina piha piha plasma (ma kahi o 900 ml / min) i hoʻohālikelike ʻia me ke kahe koko hepatic (ma kahi o 1500 ml / min).

ʻO nā maʻi maʻi

ʻAʻole loli nā pharmacokinetics o ke telmisartan i nā maʻi maʻi maʻi.

ʻO nā mea maʻi me ka maikaʻi ʻole o ka pūpū

I ka poʻe maʻi me ka renal ka hoʻomaʻemaʻe ʻana i ka hemodialysis, ʻike ʻia nā kaila plasma ma lalo. I ka poʻe maʻi me ka pilikia ʻole, pili ka telmisartan i ka protein plasma a ʻaʻole i hoʻopā ʻia i ka wā o ka dialysis. Me ka nele o ka renal, ʻaʻole i loli ka hapalua.

ʻO nā maʻi me ka palaualohi maʻa

I ka poʻe maʻi me ka maʻi hepatic, ʻo ka bioavailability piha loa o ka telmisartan e hoʻonui i ka 100%. ʻO ka hapalua hapalua no ke akeʻai ʻaʻole loli.

ʻO ka pharmacokinetics o nā inikua o ka telmisartan i loiloi i nā mea maʻi me ka maʻi hypertension (n = 57) ʻo 6 a 18 makahiki mau makahiki ma hope o ka lawe ʻana i ka telmisartan ma nā kūmole o ka 1 mg / kg a i ka 2 mg / kg no ka manawa mālama heʻehā pule. Ua hōʻoia ko nā hopena o ka noi ʻana ua paʻa ka pharmacokinetics o telmisartan i nā keiki ma lalo o nā makahiki he 12 i ka poʻe me ka pākeke a, i ka mea maʻamau ua hōʻoia ʻia ka ʻano non-linear o Cmax.

Lapaʻau lāʻau

ʻO Telsartan® kahi hana kūpono a me ka kiko (selektif) angiotensin II receptor antagonist (type AT1) no ka hoʻoponopono waha. Ke pio nei ʻo Telmisartan me ka puʻuwai kiʻekiʻe i ka angiotensin II mai kāna mau wahi hoʻopaʻa ʻia i nā mea hoʻokipa sublipe AT1, nona ka hopena i ʻike ʻia o ka angiotensin II. ʻAʻohe Telmisartan i kahi hopena agonist i ka mea hoʻokipa AT1. Hoʻopili paʻa a Telmisartan i nā ʻĀpana AT1. Ke hoʻomau nei ka pilina. ʻAʻole i hōʻike ʻo Telmisartan i ka pilina no nā mea hoʻohana ʻē aʻe, e komo pū ana me ka ʻĀpana AT2 a me nā mea ʻē aʻe, i haʻahaʻa ʻia nā mea i ʻae ʻia ʻo AT.

Ka hana koʻikoʻi o kēia mau mea nānā, a me ka hopena o ko lākou hiki ke hoʻoulu ʻia me ka angiotensin II, ke ʻano o ka piʻi ʻana me ke koho ʻana i ka telmisartan, ʻaʻole i aʻo ʻia ʻia.

Hoʻopau ʻo Telmisartan i nā pae aldosterone plasma, ʻaʻole pale i ka renin i ka plasma o ke kanaka a me nā kaila ion.

ʻAʻole i hoʻoneʻe ke Telmisartan i ka angiotensin-hoʻohuli i ka enzyme (kinase II), e hoʻopau ai i ka bradykinin. No laila, ʻaʻohe mea hoʻoikaika o nā hopena ʻili e pili ana i ka hana a bradykinin.

I loko o nā kānaka, he hapa o 80 mg o telmisartan aneane e pale iki i ka hoʻonui ʻana i ke kahe o ke koko (BP) i manaʻo ʻia e ka angiotensin II. Mālama ʻia ka hopena pale ma mua o 24 mau hola a hoʻopaʻa ʻia nō hoʻi ma hope o 48 mau hola.

Ka hoʻomaʻamaʻa ʻana o nā hypertension arterial pono

Ma hope o ka lawe ʻana i ka hapa mua o ka telmisartan, hoʻemi ʻia ke koko ma hope o 3 mau hola. ʻO ka manawa kiʻekiʻe o ke koʻi koko e hōʻemi pono nei i nā hebedoma 4 ma hope o ka hoʻomaka ʻana o ka mālama ʻana a mālama ʻia no ka manawa lōʻihi.

Pono ka hopena antihypertensive no 24 mau hola ma hope o ka lawe ʻana i ka lāʻau, me ka 4 mau hola ma mua o ka lawe ʻana i ka hopena hou, e hōʻoia ʻia nei e nā anahe o ka maʻi outpatient, a me ka paʻa (ma luna o 80%) nā kuʻina o ka liʻiliʻi a me ka piʻi ʻana o ka lāʻau lapaʻau ma hope o ka lawe ʻana i ka 40 a me 80 mg o Telsartan® i kāohi ʻia. mau pilikia hoʻokolohua.

I nā maʻi me ka maʻi hypertension, hoʻoneʻe ʻo Telsartan® i nā kaila koko systolic a me ka diastolic me ka ʻole o ka loli ʻana o ka puʻuwai puʻuwai.

Ua hoʻohālikelike ʻia ka hopena antihypertensive o ka telmisartan me nā ʻelele o nā papa ʻē aʻe o nā lāʻau antihypertensive, e like me: amlodipine, atenolol, enalapril, hydrochlorothiazide, losartan, lisinopril, ramipril a me valsartan.

I ka hihia o ka hōneʻe ʻana o ka telmisartan, hoʻoliihoi ka piʻi ʻana o ke koko i nā helu ma mua o ka mālama ʻana no kekahi mau lā me ka ʻole o nā hōʻailona o ka hoʻomau wikiwiki o ka hypertension (ʻaʻohe ʻano rebound syndrome).

Ua hōʻike ʻia nā haʻawina haukaʻi e pili ana ka telmisartan me kahi hoʻoliʻelika nui a me ka nui o ka lehulehu o ka ventricular mass a waiho i ka index ventricular mass i ka poʻe maʻi me ka hypertension arterial a waiho aku i ka hypertrophy ventricular.

ʻO nā mea maʻi me ka maʻi hypertension a me ka nephropathy maʻi i mālama ʻia me Telsartan® e hōʻike i kahi kaila nui i ka statistically (me ka microalbuminuria a me ka macroalbuminuria).

I nā hoʻokolohua lapaʻau ākea multicenter, ua hōʻike ʻia aia nā mea liʻiliʻi o nā maʻi maloʻo ma ka poʻe maʻi e lawe nei i ka telmisartan ma mua o nā mea maʻi e loaʻa ana i ka angiotensin-hoʻololi ʻana i ka hana o ka enzyme (ACE inhibitors).

Kāohi i ka morbidity cardiovascular a me ka make

I nā poʻe maʻi 55 mau makahiki a ʻoi aku ka mua o ka mōʻaukala o ka maʻi ʻalani coronary, stroke, maʻi maʻi vipula peripheral, a i ʻole diabetes mellitus me ka make kino o nā hanana (retinopathy, hypertrophy ventricular, macro a me microalbuminuria), ka hoʻohana ʻana o Telsartan® e hōʻemi i ka hanana ʻana o myocardial infarction, strokes, hospitalization e e pili ana i ka hiki ʻole o ka puʻuwai ulu a hōʻemi i ka make mai nā maʻi cardiovascular.

ʻO ka hopena antihypertensive o ka telmisartan i loiloi i nā mea maʻi me ka maʻi maʻi hypertension i ka makahiki 6 a 18 makahiki (n = 76) ma hope o ka lawe ʻana i ka telmisartan ma kahi maʻi o 1 mg / kg (mālama ʻia n = 30) a i ʻole 2 mg / kg (mālama ʻia n = 31) no ka mālamaʻana i hoʻokahi mau hebedoma. . ^ E Ha yM.

ʻO ke kahe koko nui o ka Systolic (SBP) ma ka awelika ua hōʻemi ʻia mai ka waiwai mua e 8,5 mm Hg a me 3.6 mm Hg. i nā hui telmisartan, 2 mg / kg a me 1 mg / kg, ma muli. ʻO ke kaila koko diastolic (DBP) i ka awelika i hōʻemi ʻia mai ka waiwai mua e ka 4.5 mmHg. a he 4.8 mmHg i nā hui telmisartan, 1 mg / kg a me 2 mg / kg, kēlā.

Kau ʻia nā loli i hilinaʻi ʻia.

Ua hoʻohālikelike ka ka palekana palekana ma ia nā mea maʻi.

ʻ a me ke kākele

Kuhi ʻia nā papa telmisartan no nā lānawa waha i kēlā me kēia lā a lawe ʻia me ka wai ʻole, me ka ʻole ʻole o ka meaʻai.

Ka hoʻomaʻamaʻa ʻana o nā hypertension arterial pono

ʻO ka dosis ʻōpiopio i ʻōlelo ʻia e 40 mg hoʻokahi i kēlā me kēia lā.

I nā hihia i loaʻa ʻole ai ke koko i makemake ʻia, hiki ke hoʻonui ʻia i loko o ke kao o Telsartan® ka nui o 80 mg hoʻokahi i ka lā.

Ke hoʻonui nei i ka pona, pono e noʻonoʻo ia i ka hopena antihypertensive ka hopena e hana pinepine ʻia ma loko o ʻehā a ʻewalu mau pule ma hope o ka hoʻomaka ʻana o ka mālama ʻana.

Hiki ke hoʻohana ʻo Telsartan® i ka hui pū me ka diuret thiazide, no ka laʻana, ka hydrochlorothiazide, i hui pū ʻia me ka telmisartan i kahi hopena hypotensive hou.

I ka poʻe maʻi me ka maʻi hypertension arterial, ʻo ka nui o ka telmisartan he 160 mg / lā (ʻelua papa o Telsartan® 80 mg) a hui pū me ka hydrochlorothiazide 12.5-25 mg / lā i hoʻohaʻomaʻi maikaʻi ʻia a ʻalahala.

Kāohi i ka morbidity cardiovascular a me ka make

ʻO ka dosis i ʻōlelo ʻia e 80 mg hoʻokahi i kēlā me kēia lā.

ʻAʻole i hoʻoholo ʻia inā he mau haʻahaʻa ma lalo o ka 80 mg i mea e hōʻemi ai i ka morbidity cardiovascular a me ka make.

I ka hoʻomaka mua o ka hoʻohana o ka lāʻau Telsartan® no ka pale ʻana o ka morbidity cardiovascular a me ka make kino, e pono ai e mālama i ke kahe o ke koko (BP), a he mea pono paha e hoʻoponopono i ke kahe koko me nā lāʻau lapaʻau e hoʻohaʻahaʻa i ke koko.

Hiki ke lawe ʻia ka Telsartan® me ka manaʻo ʻole o ka kōʻai ʻana o ka meaʻai.

ʻAʻole koi ʻia nā loli i nā maʻi me nā pilikia ʻole, a me nā mea maʻi ma ka hemodialysis. He palena palena nō ka mālama ʻana i nā maʻi me nā pilikia ʻole ʻole a me ka hemodialysis. No kēlā mau maʻi maʻi, e aʻo ʻia e hoʻomaka me kahi haʻahaʻa o 20 mg. ʻAʻole i lawe ʻia ʻo Telsartan® mai ke koko i ka wā o ka hemofiltration.

I ka poʻe maʻi me ka pīhoihoi haʻalulu maʻalahi ke ʻano, ʻaʻole pono ka nui o ka lāʻau i kēlā me kēia lā he 40 mg hoʻokahi i ka lā.

ʻAʻole pono ke hoʻoponopono ʻia.

Nā hopena hopena

I nā hoʻokolohua e hoʻomalu ʻia i ka maʻi i loko o nā mea maʻi me ka hypertension arterial, ʻo ka nui o nā hopena o ka ʻaoʻao i hōʻike ʻia me ka telmisartan (41.4%) i ka hoʻohālikelike ʻia me ka nui o nā hopena o ka hopena e loaʻa ana me ka pletebo (43.9%). ʻAʻole kue ka helu o kēia mau hopena i ka hopena o ke kāne, a ʻaʻole pili i ka wahine, ka makahiki, a me ka lāhui o nā maʻi.

ʻO ka ʻōlelo palekana o ka telmisartan i nā mea maʻi e lawe ana i ka lāʻau lapaʻau no ka pale ʻana i nā maʻi cardiovascular a me ka make ma ka palapala palekana no nā poʻe maʻi me ka hypertension arterial.

Loaʻa ʻia nā hopena ʻokoʻa i hōʻike ʻia ma lalo nei ma muli o ke kaohi ʻana i nā hoʻokolohua paʻa i ʻike ʻia ai ka poʻe maʻi me ka maʻi hypertension, a me nā loiloi post-marketing. Eia kekahi, ʻo nā hopena maikaʻi loa a me nā hopena hopena i alakaʻi i ka hoʻokuʻu ʻana i ka lāʻau, ua hōʻike ʻia, i hōʻike ʻia ma nā hoʻokolohua lapaʻau lōʻihi lōʻihi e pili ana i ka 21,642 nā mea maʻi i lawe i ka telmisartan e pale i ka morbidity cardiovascular a me ka make ma nā makahiki ʻeono.

Palapala ʻia nā hanana hanana ma lalo nei me ka hoʻohana ʻana i ka ʻano ka papa inoa aʻe: pinepine ≥1 / 100 a i

E hoʻokuʻu i ke ʻano a me ka ʻano

Hoʻokuʻu ʻia ka lāʻau lapaʻau ma ke ʻano o nā papa keʻokeʻo a i ʻole keʻokeʻo paha, oblong. Hoʻokahi ʻaoʻao ma ka ʻaoʻao o ka paila.

I loko o hoʻokahi papa, hiki i Telmisartan ke 40 a i ʻole 80 mg o ka waiwai hana. ʻO nā mea waiwai i ka sodium hydroxide, meglumine, povidone, magnesium stearate, hydroxypropyl methylcellulose, mannitol.

Ka hana lāʻau lapaʻau

ʻO Telmisartan kahi antagonist o nā ʻalemēʻehā o ka angiotensin 2. He hui maikaʻi maikaʻi ʻo ia me Amlodipine, no laila hui pinepineʻia kekahi me kekahi. Ma kahi o 2.5-3 mau hola ma hope o ka lawe ʻana i ka lāʻau lapaʻau, ʻike ʻia kahi emi ʻana i ke koko. ʻO ka hoʻonui loa ʻana i kona hopena e loaʻa ana i 4 wiki ma hope o ka papa o ka mālama ʻana.

Me ka hoʻoluhi ʻana o ke kaomi, ʻaʻohe hopena o kēia lāʻau lapaʻau i ka puʻuwai o ka puʻuwai a me ke ʻano o nā ʻalareka maʻi. Hoʻonā wale ʻia nā pehu ke diastolic a me ka systolic i nā hopena lāʻau lapaʻau. ʻO kēia kekahi o nā hiʻohiʻona o ka waiwai hana.

Nā ʻōkuhi no ka hoʻohana

Mālama ʻo Telmisartan i ke kahe koko ma loko o nā palena maʻamau. E kuhikuhi aku i nā ʻōlelo aʻoaʻo no ka hoʻohana ʻana i nā papa e pili ana i ka hoʻokomo o ka meaʻai. E inu wela me ka ʻole e hōʻoki. E holoi me kahi wai liʻiliʻi. ʻAʻole ia e inu i ka wai me nā mea ʻala, ʻoi hoʻi ka mea e hoʻonui ai i ka ʻai, ʻoiai e hoʻonui ana i ka hopena o ka lāʻau lapaʻau.

ʻO ka ʻoi loa ka momona ma kēlā me kēia lā ʻaʻole ʻoi aku ma mua o 40 mg. Ke hoʻomau nei ka hopena o ka lāʻau i kahi liʻiliʻi o 24 mau hola. Hoʻomaka ia e hana ma hope o 1.5 mau hola ma hope o ka hoʻokele ʻana. O ka nui loa he 80 mg. Akā me nā pilikia o ke kō, ua ʻae ʻia e inu i ka ʻole o 40 mg i ka lā.

Me ka hoʻohana mau ʻana no ka mahina hoʻokahi, ua hōʻoia ʻia ka hoʻohālikelike ʻana i ka ʻōnaehana pono.

Ke hui pū ʻia me ka ACE inhibitors, ʻo ka potassium-sparing diuretics a me ka lālani pili i ka paʻū, pono nui ka mana ʻona. ʻO ka lāʻau lapaʻau ke kumu i ka hyperkalemia. Hoʻopili ia, hoʻonui i ka hoʻonui i lithium a me ka carbonin i loko o ke koko.

ʻO Telmisartan no ka mālamaʻana i ka maʻi hypertension

Kuhi pinepine ʻia 40 mg i kēlā me kēia lā. Akā hiki ke hōʻemi ʻia ka lāʻau lapaʻau ma 20 mg inā he pono ka lāʻau lapaʻau ma ia kaha.

Inā ʻaʻole hiki iā ʻoe ke hoʻokō i ka hopena e makemake ʻia me ka lā maʻamau o 40 mg, hiki iā ʻoe ke hoʻonui, akā a hiki i ka 80 mg. Hoʻoikaika ʻia ka pau holoʻokoʻa i ka manawa. Ke hoʻoholo nei i kahi hoʻoponopono o ka dosage, pono e noʻonoʻo i ka hopena ʻaʻole i loaʻa koke, akā ma hope o 1-2 mau mahina o ka hoʻokomo pinepine ʻana i nā papa.

I mea e hōʻemi ai i ke koko, ʻo Telmisartan e kuhikuhi pinepine i ka manawa like me ka diuret thiazide.

ʻO Telmisartan no ka hoʻonuiʻana i ke ola ma ka maʻi cardiovascular

ʻO ka hopena o Telmisartan no ka pale ʻana i ka make ma ka poʻe me nā maʻi o ka ʻōnaehana cardiovascular i hoʻomaopopo ʻia i kahi maʻi o 80 mg i kēlā me kēia lā. ʻAʻole ʻike ʻia kahi hopena like ma nā haʻahaʻa haʻahaʻa.

Inā loaʻa iā ʻoe nā pilikia me nā aʻalolo a maʻa paha, pono ʻoe e hoʻolilo ma kēia kīhāpai ʻaʻole ia i nā hopena hopena mai kēia mau kino. Hoʻomaopopo ʻia e hoʻomaka me ka pā o 20 mg i kēlā me kēia lā. No ka hapanui o nā poʻe maʻi me ka hana maʻi lēwa ʻole, kahi maʻa ma luna o 40 mg i kēlā me kēia lā he pōʻino.

E heluhelu pū i kēia ʻatikala: Lercanidipine: 10 mg a me 20 papa papa

Nā Hoʻohui

ʻAʻole i kuhikuhi ʻia ʻo Telmisartan i kēia mau helu:

ʻaʻole e ʻae i ke fructose e ke kino,
kuikahi i ka piula o ka apana pili,
hapai a lactation
nā keiki a me nā ʻōpio (a hiki i ka 18 makahiki),
hypersensitivity o nā ʻāpana,
hōʻeha maʻi nui a me ka renal maikaʻi ʻole,
hoʻonui mahuahua o ka hormone aldosterone - Conn syndrome, ma muli o ka hoʻomohala ʻana o ke ʻanoʻano ʻaʻano i loko o nā kelepa adrenal,
malabsorption glucose-galactose.

ʻO ka poʻe e hōʻeha nei i ka maʻi ʻalihi coronary, ʻeha gastric a duodenal ulia, kokoke i ke koko, pono lākou e nānā i nā helu koko a hoʻolohe i ko lākou mau manaʻo ponoʻī.

Pono ke kauka e nānā i ke kūlana o nā maʻi e pale ai i nā hōʻeha.

Nā hopena hopena

Ke hoʻohana ʻia nei i ka lāʻau lapaʻau, hiki i kekahi mau hopena kūpono ke ʻano, e komo pū ana me ka hoʻomohala ʻana o ka maʻi withdrawal ma hope o ka hoʻohana ʻana:

uukū maʻi
myalgia
ninaki a me ka luaʻi
ʻūlū
lolilolinia,
pharyngitis
poʻomanaʻo
pono huakai,
huhuhu,
āhāhuʻe
ʻeha a me ka ʻeha i loko o ka ʻāina lumbar,
anemia
nā hana hoʻonui o nā transaminases hepatic,
emi i ke koko,
hoʻonui ulu irritability
nā kūlana kaumaha
nāliʻi a i ʻole ka constipation
kaʻiliʻili
ka hana paʻa i ka pūnāwai
ʻO ka edema ʻo Quincke (ʻike pinepine ʻole),
nā wahi hiamoe hiamoe
wahī
ka hoʻemi ʻana o ka hemoglobin i loko o ke koko koko,
ua ʻeha ka ʻōpū
arrhythmia a me ka tachycardia.

Nā ʻōlelo kikoʻī

Hoʻohana pono ka mālama ʻana i nā maʻi i hiki ai i kahi kaʻa a hana paha i koi nui ʻia ka hana, me ka mea he dizziness.

Pono e nānā i nā loli i ka pae o ka electrolyte, BCC, ka mālama pono ʻana i ke kūlana o nā poʻe maʻi i loaʻa mua i ka pilikia me ka palā a me nā ʻōpū a i ʻole kekahi stenosis o nā kīʻaha o ka palau, stenosis o aorta a mitral paha o ka puʻuwai, obstructive hypertrophic cardiomyopathy, hōʻeha puʻuwai paʻakikī, ʻeha puʻuwai coronary, ʻāhā peptic, koko a i ʻole ka hoʻā kokoke ʻana i nā maʻi.

Hoʻohui nūhou

Inā ʻoe e inu i ka Telmisartan 80 mg a i 40 mg me Digoxin, a laila e piʻi ka nui o ke koʻikoʻi ma ke koko. I ka manawa like, ʻo ka inu ʻana i ka lāʻau i ho'ākāka ʻia ma luna nei a me ka diuretics potassium-sparing ʻaʻole ʻia. ʻO ka mālama like ʻana o Telmisartan a me NSAIDs (nā like aspirin like) e hōʻemi i ka hopena, i loko o kahi e hoʻonui ai ke kaʻe o ka mea maʻi.

Ke lawe nei i Telmisartan me nā lāʻau lapaʻau e hoʻemi i ke koko, hiki iā ʻoe ke hoʻokō i ka nui o ke kahe o ke koko i ka pae momona. No laila, ʻoi aku ka maikaʻi o ka lawe ʻole ʻana i nā ʻano lāʻau like i ka manawa hoʻokahi, ke kumu o ka lawe ʻana i ke kaila koko i ka maʻamau.

Inā inu ʻoe i ka Telmisartan 40 a i ka 80 mau manawa me ka corticosteroids, e hōʻemi kēia i ka hopena antihypertensive (hoʻohaʻahaʻa i ka hopena).

Nā kikowaena o Telmisartan

E hoʻoholo ke ana i ke kumuhana:

Hoʻonohonoho nā Angiotensin 2 mau anagonist e hoʻopili:

Kāleka
Kukuiono
Lorista
Irsar
Karzartan
Kāleka
Irbesartan
Olimestra
Teveten
Mikardis Plus
Ibertan
Atacand
Valz
Valsartan
Hyposart,
Cardostin
Lozarel
Keola
Zisakar
Nortian
Nā Telsartan
Diovan
Tantordio
Naviten
Tanidol
Xawai
Telzap
Vasotens,
Telmista
Blocktran
Hoʻōla
Kālehu
Lotor
Renicard
Edarby
Losartan
Telmisartan
Lozap,
Cardosten
Tareg
Apolo
Kūwila,
Koiā ʻia
Eni,
Hoʻolaha
Lakea
Presartan
Candesartan
Sartavel
Angiakand.

E hoʻokuʻu i nā palapala a me ka ʻano

ʻO ka lāʻau lapaʻau he papa papa ʻulaʻula ʻole me ka ʻole o ka pale, convex ma nā ʻaoʻao ʻelua. Ma ka ʻaoʻao ma luna o kēlā me kēia mea i loaʻa ka pilikia no ka maʻalahi o ka haki ʻana a me nā leka "T", "L", i ka ʻaoʻao i lalo - ka helu "40". I loko, hiki iā ʻoe ke ʻike i nā wahī 2: kahi pinkish i loko o ke kala o nā mea hoʻoikaika ʻole, ʻē aʻe kekahi i keʻokeʻo, i kekahi manawa me nā inclusions liʻiliʻi.

I ka papa papaʻa o kahi hui pūʻokoʻa - 40 mg o ka papa hana nui o ka telmisartan a me 12.5 mg o ka diuretic hydrochlorothiazide.

Hoʻohana ʻia nā mea kōkua.

mannitol
lactose (waiū waiu),
povidone
Nā meglumine
konekena stearate,
sodium hydroxide
803
poloka E172.

I ka papa papaʻa o kahi hui pūʻokoʻa - 40 mg o ka papa hana nui o ka telmisartan a me 12.5 mg o ka diuretic hydrochlorothiazide.

Nā Papa o 6, 7 a i ʻole 10 mau kamepiula. hoʻokomo ʻia i loko o nā blisters i hoʻokumu ʻia i ka alumini foil a me ka kiʻi polū. Hoʻopili ʻia i nā pahu pahu pepa 2, 3 a 4 paha mau leta.

Lapaʻau lāʻau

ʻO ka hui pū ʻana o ka telmisartan me hydrochlorothiazide ʻaʻole e loli i ka pharmacokinetics o nā mea. ʻO kā lākou huakaʻi holoʻokoʻa he 40-60%. Hoʻopili koke ʻia nā mea ikaika o ka lāʻau mai ka digestive tract. ʻO ka pae kiʻekiʻe loa o ka telmisartan hōʻiliʻili i loko o ke koko koko ma hope o 1-1,5 mau hola he 2-3 mau manawa haʻahaʻa i lalo o nā kāne ma mua o nā wahine. Hoʻokomo ka hoʻokaʻawale ʻaoʻao i nā pepi, hoʻoneʻe ʻia kēia mea waiwai i nā moʻo. Hoʻokuʻu ʻia ka Hydrochlorothiazide mai ke kino a aneane i loli ʻole me ka urine.

Nā hōʻailona no ka hoʻohana ʻana

ma ka mālama ʻana i ka hypertension mua a me ka lua, inā ʻo ka mālama ʻana me ka telmisartan a i ʻole hydrochlorothiazide ʻo ia wale nō e hāʻawi i ka hopena i makemake ʻia,
i mea e pale ai i nā hoʻopiʻi o nā maʻi cardiovascular koʻikoʻi ma ka poʻe i ʻoi aku ma mua o 55-60 mau makahiki,
i ka mea e pale ai i nā hoʻopiʻi i nā maʻi me ka maʻi II II (non-insulin-dependant) me ka ʻeha kino i hoʻoneʻe ʻia e ka maʻi lalo.

Hoʻohana i ka wā hāpai a me ka lactation

Kahawai

Hoʻokomo ʻia ka lāʻau lapaʻau no nā wahine hāpai a i nā wahine paha e hoʻolālā ana i ka wā hāpai. Inā hoʻopaʻa ʻia ka male ʻana i ka wā e mālama ai me kēia loea, e hoʻopau koke ʻia kāna hoʻohana a, inā pono, ke hoʻololi ʻia me kekahi lāʻau lapaʻau i ʻae ʻia no ka hoʻohana ʻana i nā wahine hāpai (e ʻike i nā Māhele "Contraindications" a "Nā hiʻohiʻona o ke hoʻohana").
ʻAʻohe data e pili ana i ka hoʻohana ʻana o Telmisartan no nā wahine hāpai.

ʻO ke kumu o ka epidemiological no ka hopena o ka teratogenicity ma muli o ka hoʻohana ʻana o nā inhibitor ACE i ka manawa mua o ka mākō mua o ka hapai i kūʻiʻo ʻole ʻia, akā, ʻaʻole i hoʻokele iki ʻia kahi liʻiliʻi i palena ʻole. ʻOiai ʻaʻohe mea e hōʻike i ka hōʻike epidemiological e pili ana i ka hopena teratogenicity me ka ʻoniʻoni neʻepela ka angiotensin II.

ʻAʻole pono e hoʻomaka ʻo Angiotensin II receptor antagonist i ka wā hāpai. Inā e hoʻomau ʻia ka hoʻomau ʻia o ka hoʻomau i ka lapaʻau ʻana me ka antagonist angiotensin II, a ke hoʻolālā nei ke kanaka maʻi i ka wā e hāpai ana i ka hapai ʻana, ʻoi aku ia e hoʻololi i ka mālama ʻana i ka terapi antihypertensive me kahi paʻa palekana paʻa i ka wā hāpai. Inā paʻa ka hānai, pono e hoʻokaʻawale koke i ka lāʻau me kaiotiotinin receptor antagonist.

Ua ʻike ʻia ka hoʻohana ʻana o ka angiotensin II antagonist receptor i ka wā o ka II a me III e hoʻomaʻamaʻa ʻana i ka hapai e hāpai ana i ka fetotoxicity i nā kānaka (hana ʻino ʻole i loko o ka maʻi, oligohydramniosis, lohi i ka hana o nā iwi cranial) a me nā meaʻeha o ka neonatal (pilikia ʻole, hypotension, hyperkalemia). Inā hoʻomaka ka hoʻohana ʻana o ka antagonist reseptor angiotensin II mai ka lua o ka hapalua o ka hapai ʻana, e kuhikuhi ʻia e hoʻokō i kahi loiloi ultrasound o ke akeʻa a me nā iwi o ka iwi ʻōlo. ʻO ke kūlana o nā pēpē i lawe ʻia e kona mau makuahine i ka anagonistin II receptor antagonist e nānā pono ʻia no ka maka o ka hypotension arterial (e nānā i nā Māhele "Contraindications" a "Features of use").

Haumana ʻaʻai.

ʻAʻole makemake ʻia ʻo Telmisartan i ka wā mālama umauma, no ka mea ʻaʻole i ʻike ʻia inā ua excreted i ka waiū kanaka. Hoʻohana ʻia ka hana hou ʻana me ka maikaʻi palekana aʻo hou ʻia ka ʻoihana palekana, ʻoi aku ka nui o ka wā e hoʻolako ai i kahi pēpē a hānau keiki paha.

Ke keu

Hoʻohiki ka ʻikepili e pili ana i ka lāʻau lapaʻau ma luna o nā kānaka.

Nā Hoʻomaka ʻO nā hopena maikaʻi loa i kahi overdose o ka telmisartan o ka hypotension a me ka tachycardia, a me ka bradycardia, kaʻawaʻawa, hoʻonui i ka serum creatinine, a me nā mea huehue hoʻokoloke i hōʻike ʻia.

Hoʻomaʻamaʻa. ^ E Ha yM. ʻAʻole kū ʻia ʻo Telmisartan i ka wā hemodialysis. Pono nā mea maʻi e nānā pono a me ka hōʻailona a me ke kākoʻo kākoʻo i kuhikuhi ʻia. Aia ka maʻi ma muli o ka manawa i hala aku ma hope o ka lawe ʻana i ka nui o ka hōʻalo a me ka nui o nā hōʻailona. Hoʻokomo ʻia nā hana i hoʻomohala ʻia ai ka luaʻi a me ka luaʻi gastric. Hiki ke hoʻohana 'ia ana i ka kalaiwa i ka mālama ʻana i ka overdose. E nānā pinepine i nā electrolytes serum a me nā pae kiʻekiʻe. Inā he maʻi hypotension ka mea maʻi, pono ʻo ia e lawe i kahi kūlana, a pono hoʻi ʻo ia e hoʻomaka koke i nā hana e hoʻihoʻi ai i ke kaulike o nā kahe a me nā electrolytes.