ʻAflelo ʻo Protafan NM Penfill - kuhikuhi mana no ka hoʻohana ʻana

Hoʻopaʻa no ka hoʻokele subcutaneous, 100 IU / ml

1 ml o ke kaawale ʻaole

mea waiwai - genetic engineering human human insulin (insulin-isophan) 100 IU (3.5 mg),

nā mea hoʻowalewale: protamine sulfate, zinc, glycerin, metacresol, fenol, sodium hydrogen phosphate dihydrate, 2 M sodium hydroxide, 2 M hydrochloric acid, wai no ka injection.

ʻO kahi pēpē keʻokeʻo, ka mea e kū ana, e kū nei i kahi kukui maopopo ʻole i ʻoniʻoni ʻole a i ʻole ʻulaʻula. Hoʻopau maʻalahi ke kūleʻa i nā neʻe me ka haʻalulu haʻalulu.

ʻO nā waiwai Pharmacological

Lapaʻau lāʻau

ʻO ka lōʻihi o ka hana o ka hoʻomākaukau ʻana o ka insulin no ka nui o ka absorption, ka mea e hilinai ana i nā mea he nui (no ka laʻana, ma ke ʻano o ka insulin, ke ʻano a me kahi wahi o ka hoʻokele ʻana, ka mānoanoa o ka momona momona a subcutaneous a me ke ʻano o ka maʻi mellitus). No laila, ʻo nā pākuʻi o ka pharmacokinetic o nā insulin e hana i nā ʻano nui o ka hui a me ka intra-individu.

ʻO ka pae kiʻekiʻe loa (Cmax) o ka insulin i ka plasma ua loaʻa i loko o 2-18 mau hola ma hope o ka hoʻokele subutanutan.

ʻAʻohe mea i ʻōlelo ʻia e pani ʻia i nā protein plasma e ʻike ʻia, me ka hoʻoleʻa o nā antibodies i nā insulin.

Hoʻopili ʻia ka hana like o ke kanaka e ka hana o kahi insulin protease a i ʻole ka pale ʻana i ka hana o ka insulin, a hiki paha ma ke ʻano o ka protein disulfide isomerase. Ua manaʻo ʻia aia aia i loko o nā kinipona o ka insulin kanaka he nui nā wahi o ka cleavage (hydrolysis), eia naʻe, ʻaʻohe mea hana o ka metabolites i hoʻokumu ʻia ma muli o ka palaki i ka hana.

ʻO ka hapalua-ola (T½) i hoʻoholo ʻia e ka helu o ke kahe mai mai ka kiko kiko. No laila, ʻo T½ ʻoi aku kahi ana o ka loaʻa ʻana, ʻaʻole ma mua o ke ana maoli o ka hoʻoneʻe ʻana i ka insulin mai ka plasma (T½ o ka insulin mai ke kahawai. He mau minuke wale nō he mau minuke). Ua hōʻike ʻia nā noiʻi ʻana ʻo T½ ma kahi o 5-10 hola.

Lapaʻau lāʻau

ʻO Protafan® NM kahi mea hana e hana ai i ka insulin o ke kanaka e hana ʻia e ka biotechnology DNA recombinant e hoʻohana ana i ka manaʻo Saccharomyces cerevisiae. ʻO ka emi ʻana o ke kaʻe o ka glucose i ke koko e kū ana ma muli o ka hoʻonui o kāna kaomi intracellular ma hope o ka hoʻopaʻa ʻana i ka insulin i ka receptors insulin i nā uaua adipose a me ka hoʻohaʻahaʻa like ʻana i ka hopena o ka hana glucose i ka ate.

Hoʻomaka ka hana a ka lāʻau lapaʻau ma loko o 1½ mau hola ma hope o ka hoʻokele ʻana, hōʻike ʻia ka hopena loa i loko o 4-12 mau hola, ʻoiai ka lōʻihi o ka hana o ka hana he 24 hola.

ʻ a me ke kākele

Kuhi ʻia ka lāʻau no ka hoʻokele subcutaneous. ʻAʻole hiki ke hoʻokele pono ʻia ka hoʻōlaʻana o ka insulin.

Hiki ke hoʻohana ʻia ka Protafan® NM ma ka monotherapy a me ka hoʻohui pū me ka insulin hana wikiwiki a pōkole wale nō.

Koho ʻia ke ʻano o ka lāʻau lapaʻau hoʻokahi, me ka noʻonoʻo ʻana i nā pono o ka mea maʻi. ʻO ka maʻamau, ma waena o 0.3 a me 1 IU / kg / lā. ʻO ke koi o kēlā me kēia lā he nui i ka insulin i mea kiʻekiʻe ma nā mea maʻi me ka pale ʻana i ka insulin (no ka laʻana, ma ka wā ʻōpiopio, a me ka poʻe maʻi me ka huelo), a e hoʻohaʻahaʻa hoʻi i nā mea maʻi me ka hoʻomaha o ka hana endogenous insulin.

Hoʻokomo pinepine ʻia ʻo Protafan® HM ma ka ʻōpū o ka ʻōpū. Inā kūpono kēia, a laila hiki ke hana ʻia nā inikini ma ka paia o ka ʻōpū o ka naʻau, i loko o ka wahi o ke ala a i ka hopena o nā ʻono o ke ʻano o ka poʻohiwi. Me ka hoʻopuka ʻana o ka lāʻau lapaʻau i loko o ka ʻūhā, aia ke ʻano o ka pānaʻi lohi ma mua o ke komo ʻana i nā wahi ʻē aʻe. Inā hana ʻia ka ʻōlohelohe i loko o kahi pālahalaha olakino, a laila hoʻēmi ʻia ka nui o ka ʻeha o ka hoʻokele intramuscular o ka lāʻau.

Pono ka noho iki ma lalo o ka ʻili no ka liʻiliʻi o 6 kekona, e hōʻoiaʻiʻo ana i kahi maʻi piha. Pono e hoʻololi mau i ka pūnaewele injection i loko o ke kahawai anatomical i mea e pale ai i ka hoʻomohala ʻana o ka lipodystrophy.

Hiki ke hoʻohana pū ʻia ka Protafan® HM i nā kīʻaha me nā ʻili like me ka syringes, e kau ʻia ai kahi mākaʻi, e ʻae ana i ka helu ʻana o ka insulin i loko o nā ʻāpana o ka hana.

Ke hāʻawi ʻia nei nā ʻōkuhi no ka hoʻohana ʻana i ka Protafan® NM i ka mea maʻi.

Mai hoʻohana iā Protafan® NM:

I loko o nā pamu insulin.

Inā aia kekahi allergy (hypersensitivity) i ka inika manuahi a i ʻole kekahi o nā mea i hana i ka lāʻau Protafan® NM.

Inā hoʻomaka ka hypoglycemia (liʻiliʻi koko koko).

Inā ʻaʻole i mālama pono ʻia ka insulin, a i ʻole a mālamalama

Inā nalowale ka pale pale a nalo wale paha. He pākiki pale pale ʻia kēlā me kēia pahu.

Inā ʻaʻole i ka lole keʻokeʻo keʻokeʻo a ʻolua hoʻi ma hope o ke kāwili ʻana.

Ma mua o ka hoʻohana ʻana iā Protafan® NM:

E nānā i ka lepili e hōʻoia ai ʻoe e hoʻohana ana i ka ʻano like o ka insulin.

Wehe i ka pāpale pale.

Pehea e hoʻohana ai i ka lāʻau lapaʻau Protafan® NM

ʻO ka lāʻau ʻo Protafan® NM no ka hoʻokō subutaneus. Mai hoʻokaʻawale i ka insulin intravenously a i ʻole intramuscularly. E hoʻololi mau i nā pūnaewele injection i loko o ke kahua anatomical e hōʻemi i ka hopena o nā sila a me nā ulia ma ka wahi i hoʻopaʻa ʻia. ʻO nā wahi maikaʻi loa no nā inikini: mau ʻūhā, nā ʻūhā mua a i ʻole poʻohiwi poʻohiwi.

Pehea e lawelawe ai iā Protafan® NM inā ke hoʻomalu wale ʻia ʻo Protafan® NM a i ʻole ʻo Protafan® NM e hui pū me ka insulin hana pōkole

Hōʻoiaʻiʻo e hoʻohana i kahi syringe insulin kahi e kau ʻia ai kahi meahana e hoʻopaʻa ai i ka paukū i nā pūʻulu o ka hana.

E huki i ka lewa i loko o ka syringe i ka nui e like me ka nui o ka inanini o ka insulin.

Ma mua o ka lawe ʻana i ka waiā, e ʻōwili i ka hue ma waena o kou mau palemata a hiki i ke keʻokeʻo a keʻokeʻo a me nā ao ke insulin. Māhuahua ʻia ka Resuspension inā he pākaha ka lumi o ka lāʻau.

E komo i ka insulin ma lalo o ka ʻili.

Mālama i ka pono ma lalo o ka ʻili no ka liʻiliʻi o 6 kekona e hōʻoia ai ka hoʻokele piha ʻana o ka inika i ka insulin.

ʻO nā maʻi e like me ka maʻi hopohopo a hele pū ʻia me ke kuni, e hoʻonui pinepine i ke kino o ka maʻi o ka insulin. Hiki ke koi ʻia i ka hoʻoponopono ʻana inā he maʻi nā mea maʻi i nā maʻi, nā ate, ka hana adrenal functioning, pituitary a i ʻole thyroid gland.

Hiki pū paha i ka hoʻoponopono no ka hoʻoponopono ʻana i ka wā e hoʻololi nei i ka hana kino a i ka ʻai maʻamau o ka mea maʻi. Hiki ke koi ʻia ka hoʻoponopono ʻana i ka neʻe ʻana i ka mea maʻi mai kahi ʻano like ʻole o ka insulin i kekahi.

Nā hopena hopena

ʻO nā hopena ʻeha i nānā ʻia i nā maʻi e mālama ʻia me ka Protafan® NM i hilinaʻi nui ʻia ka nui o ka dosis a ma muli o ka hana pharmacological o insulin.

ʻO kēia ka waiwai o ke kiko o ka hana ʻino i hōʻike ʻia i ka wā o nā hoʻokolohua lapaʻau, i ʻike ʻia me ka hoʻohana ʻana i ka lāʻau lapaʻau ʻo Protafan® NM. ʻO ka neʻe o ka neʻe i koho ʻia penei: infrequently (≥1 / 1,000 a

Nā pālua:

ʻŌpū a me ka lactation
ʻAʻohe mea paʻa i ka hoʻohana ʻana o ka insulin i ka wā hapai, no ka mea, ʻaʻole i kū ka insulin i ka papale placental. Eia kekahi, inā ʻaʻole ʻoe e mālama i ka maʻi diabetes i ka wā o ka hāpai ʻana, e hoʻomohala nei i ka pūpū. No laila, hoʻomau ʻia ka lāʻau lapaʻau i ka wā hāpai.
ʻO nā hypoglycemia a me hyperglycemia, kahi e hiki ai ke hoʻomohala i nā pilikia o nā lāʻau lapaʻau i koho ʻia ʻole, hoʻonui i ka nui o ka hoʻopā ʻana o nā maʻi fetal a me nā make fetal. ʻO nā wahine hāpai i ka maʻi maʻi e nānā pono ʻia i ka wā o ko lākou hānau ʻana, pono lākou e hoʻonui i ka kaohi o ke kaila glucose o ke kō, nā loina like e pili ana i nā wahine e hoʻolālā nei i kahi hapai.
Ka pono o ka insulin e hoʻohaʻahaʻa i ka mea hoʻomaʻama mua o ka hapai a hoʻonui pinepine ʻia i ka trimesters lua a me ke kolu.
Ma hope o ka hānau keiki ʻana, ʻoi ka pono o ka insulin e hoʻi hou i ka pae i kaulana i mua o ka wā hapai.
ʻAʻole hoʻi nā kau palena o ka hoʻohana ʻana i ka lāʻau Protafan NM i ka lactation. ʻAʻole hōʻeha ka Insulin therapy no nā hānai kahu maʻi no ka pēpē. Eia naʻe, pono i ka makuahine ke hoʻoponopono e hoʻoponopono i ka ʻaiā ma muli o ka lāʻau Protafan NM a me ʻole.

ʻElua hopena:

Kuhi loa-hopena i ka hoʻihoʻi anaphylactic.
Nā hōʻailona o ka hypersensitivity generalized e pili ana i ka ʻāʻī o ka ʻili, ʻōlohelohe, lūlū, nā hōʻeha o ka gastrointestinal tract, angioedema, pōkole o ka hanu, palpitations, hoʻemi i ke koko, nāwaliwali / nāwaliwali.
ʻO nā hopena hypersensitivity ākea hiki i ke hoʻoweliweli ʻana i ke ola.

ʻO nā maʻi o ka pūnao
Kēiaʻi paʻakikī koʻikoʻi o peripheral neuropathy.
Inā loaʻa kahi wikiwiki i ka mālama koko glucose i hopena koke, hiki i kahi kūlana i kapa ʻia "neuropathy hōʻeha" e hoʻomohala i nā mea maʻamau.

Kuee ʻia o nā io o ka ʻike
Kuhi loa loa i nā hemahema.
ʻO nā mea hōʻino kino i hoʻomaʻamaʻa pinepine ʻia i ka hoʻomaka mua ʻana o ka maʻi insulin.
E like me ke kānāwai, he hoʻololi kēia mau hōʻailona.

ʻO ka pinepine - retinopathy diabetic.
Inā hāʻawi ʻia ka mālama glycemic kūpono no ka manawa lōʻihi, ua hoʻemi ʻia ka nui o ka piʻi ʻana o ka maʻi retinopathy diabetes. Eia naʻe, ʻo ka hoʻonui ʻana i ka inikini insulin me ka hoʻonui maikaʻi loa i ka mālama glycemic hiki ke alakaʻi i kahi manawa pōkole i ka nui o ka maʻi o ka retinopathy diabetes.

Nā maʻi hōʻeha o ka ʻili a me ke kiko
Hewa - lipodystrophy.
Hiki i ka Lipodystrophy ke hoʻomohala ma ka pūnaewele injection i ka hihia inā ʻaʻole lākou e hoʻololi mau i ka pūnaewele injection i loko o ka wahi like o ke kino.

ʻO nā hoʻohālikelike mai ke kino ma ke ʻano he nui, a me nā hopena hoʻi ma ka wahi i hōʻike ʻia
Hoko - nā luhi ma ka wahi i ʻōlelo ʻia.
E pale aku i ke ʻano o ka insulin insulin, hiki i nā hopena ke hopena ma ka pūnaewele injection (ʻulaʻula o ka ʻili, ka huehue, ka puhaka, ka ʻeha, ka ʻano hematoma ma ka wahi i ʻōlelo ʻia). Eia nō naʻe, i ka hapanui o kēia mau hopena, ua loli kēia mau hopena i ka hana a nalowale i ka hana o ka hoʻomau mau ʻana.

ʻOhiʻeha - puffiness.
Hoʻomaopopo pinepine ka puhi ʻana ma ka hoʻomaka mua o ka maʻi insulin. Ma ke ʻano he kānāwai, he mau kēia mahele i ke ʻano.